Markus Grompe

Markus Grompe

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Markus Grompe

Publications by authors named "Markus Grompe"

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AAV-Mediated CRISPR/Cas9 Gene Editing in Murine Phenylketonuria.

Mol Ther Methods Clin Dev 2020 Jun 24;17:234-245. Epub 2019 Dec 24.

Department of Molecular and Medical Genetics, Oregon Health & Science University, Portland, OR 97239, USA.

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http://dx.doi.org/10.1016/j.omtm.2019.12.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6962637PMC
June 2020

Efficient editing of OTC-deficient patient-derived primary human hepatocytes.

JHEP Rep 2020 Feb 27;2(1):100065. Epub 2019 Dec 27.

Gene Therapy Research Unit, Children's Medical Research Institute, Faculty of Medicine and Health, The University of Sydney and Sydney Children's Hospitals Network, Westmead, Australia.

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http://dx.doi.org/10.1016/j.jhepr.2019.100065DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7005564PMC
February 2020

In Vivo Lineage Tracing of Polyploid Hepatocytes Reveals Extensive Proliferation during Liver Regeneration.

Cell Stem Cell 2020 Jan 19;26(1):34-47.e3. Epub 2019 Dec 19.

Department of Pediatrics, Oregon Health and Science University, Portland, OR 97239, USA. Electronic address:

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http://dx.doi.org/10.1016/j.stem.2019.11.014DOI Listing
January 2020

Endoplasmic Reticulum Stress-Induced Upregulation of STARD1 Promotes Acetaminophen-Induced Acute Liver Failure.

Gastroenterology 2019 08 25;157(2):552-568. Epub 2019 Apr 25.

Cell Death and Proliferation, IIBB-CSIC, Barcelona, Spain; Liver Unit, Hospital Cínic, IDIBAPS and CIBEREHD, Barcelona, Spain; USC Research Center for ALPD, Keck School of Medicine, Los Angeles, California. Electronic address:

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http://dx.doi.org/10.1053/j.gastro.2019.04.023DOI Listing
August 2019

Diabetes relief in mice by glucose-sensing insulin-secreting human α-cells.

Nature 2019 03 13;567(7746):43-48. Epub 2019 Feb 13.

Department of Genetic Medicine and Development, iGE3 and Centre Facultaire du Diabète, Faculty of Medicine, University of Geneva, Geneva, Switzerland.

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http://dx.doi.org/10.1038/s41586-019-0942-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6624841PMC
March 2019

Combination therapy with atorvastatin and celecoxib delays tumor formation in a Fanconi anemia mouse model.

Pediatr Blood Cancer 2019 01 25;66(1):e27460. Epub 2018 Sep 25.

Oregon Stem Cell Center, Department of Pediatrics, Oregon Health and Science University, Portland, Oregon.

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http://doi.wiley.com/10.1002/pbc.27460
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http://dx.doi.org/10.1002/pbc.27460DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6249055PMC
January 2019

Inflammatory Cytokine TNFα Promotes the Long-Term Expansion of Primary Hepatocytes in 3D Culture.

Cell 2018 11;175(6):1607-1619.e15

Howard Hughes Medical Institute, Department of Developmental Biology, Institute for Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S00928674183150
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http://dx.doi.org/10.1016/j.cell.2018.11.012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6497386PMC
November 2018

Monitoring liver damage using hepatocyte-specific methylation markers in cell-free circulating DNA.

JCI Insight 2018 06 21;3(12). Epub 2018 Jun 21.

Department of Developmental Biology and Cancer Research, The Institute for Medical Research Israel-Canada, The Hebrew University-Hadassah Medical School, Jerusalem, Israel.

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http://dx.doi.org/10.1172/jci.insight.120687DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6124429PMC
June 2018

Long-Term Correction of Diabetes in Mice by In Vivo Reprogramming of Pancreatic Ducts.

Mol Ther 2018 05 21;26(5):1327-1342. Epub 2018 Feb 21.

Oregon Stem Cell Center, Papé Family Pediatric Research Institute, Oregon Health & Science University, Portland, OR 97239, USA; Department of Molecular and Medical Genetics, Oregon Health & Science University, Portland, OR 97239, USA. Electronic address:

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http://dx.doi.org/10.1016/j.ymthe.2018.02.014DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5993989PMC
May 2018

Successful Engraftment of Human Hepatocytes in uPA-SCID and FRG KO Mice.

Methods Mol Biol 2017 ;1506:117-130

Departments of Clinical Chemistry, Microbiology and Immunology, Ghent University, University Hospital Ghent, MRB2, De Pintelaan 185, Ghent, 9000, Belgium.

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http://dx.doi.org/10.1007/978-1-4939-6506-9_8DOI Listing
January 2018

Fah Knockout Animals as Models for Therapeutic Liver Repopulation.

Authors:
Markus Grompe

Adv Exp Med Biol 2017 ;959:215-230

Oregon Stem Cell Center, Department of Pediatrics, Oregon Health and Science University, Portland, OR, 97239-3098, USA.

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http://link.springer.com/10.1007/978-3-319-55780-9_20
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http://dx.doi.org/10.1007/978-3-319-55780-9_20DOI Listing
December 2017

Reprogramming human gallbladder cells into insulin-producing β-like cells.

PLoS One 2017 16;12(8):e0181812. Epub 2017 Aug 16.

Oregon Stem Cell Center, Papé Family Pediatric Research Institute, Oregon Health & Science University, Portland, Oregon, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0181812PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5558938PMC
October 2017

Adult Mouse Liver Contains Two Distinct Populations of Cholangiocytes.

Stem Cell Reports 2017 08 6;9(2):478-489. Epub 2017 Jul 6.

Oregon Stem Cell Center, Oregon Health and Science University, Portland, OR 97239, USA; Papé Family Pediatric Research Institute, Oregon Health and Science University, Portland, OR 97239, USA; Department of Pediatrics, Oregon Health and Science University, Portland, OR 97239, USA. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S22136711173026
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http://dx.doi.org/10.1016/j.stemcr.2017.06.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5549808PMC
August 2017

A Drug Screen using Human iPSC-Derived Hepatocyte-like Cells Reveals Cardiac Glycosides as a Potential Treatment for Hypercholesterolemia.

Cell Stem Cell 2017 04;20(4):478-489.e5

Department of Cell Biology, Neurobiology, and Anatomy, Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, WI 53226, USA; Department of Regenerative Medicine and Cell Biology, Medical University of South Carolina, 173 Ashley Avenue, Charleston, SC 29425, USA; Hollings Cancer Center, Medical University of South Carolina, 86 Jonathan Lucas Street, MSC 955, Charleston, SC 29425, USA. Electronic address:

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http://dx.doi.org/10.1016/j.stem.2017.01.011DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5385853PMC
April 2017

Chronic Phenotype Characterization of a Large-Animal Model of Hereditary Tyrosinemia Type 1.

Am J Pathol 2017 Jan 14;187(1):33-41. Epub 2016 Nov 14.

William J. von Liebig Center for Transplantation and Clinical Regeneration, Mayo Clinic, Rochester, Minnesota; Department of Surgery, Mayo Clinic, Rochester, Minnesota. Electronic address:

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http://dx.doi.org/10.1016/j.ajpath.2016.09.013DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5225308PMC
January 2017

Metformin improves defective hematopoiesis and delays tumor formation in Fanconi anemia mice.

Blood 2016 12 18;128(24):2774-2784. Epub 2016 Oct 18.

Oregon Stem Cell Center, Department of Pediatrics, Oregon Health & Science University, Portland, OR.

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http://dx.doi.org/10.1182/blood-2015-11-683490DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5159699PMC
December 2016

Efficient generation of pancreatic β-like cells from the mouse gallbladder.

Stem Cell Res 2016 11 27;17(3):587-596. Epub 2016 Oct 27.

Oregon Stem Cell Center, Papé Family Pediatric Research Institute, Oregon Health & Science University, Portland, OR, USA. Electronic address:

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http://dx.doi.org/10.1016/j.scr.2016.10.009DOI Listing
November 2016

Single-Cell Mass Cytometry Analysis of the Human Endocrine Pancreas.

Cell Metab 2016 10;24(4):616-626

Department of Genetics and Institute for Diabetes, Obesity, and Metabolism, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S15504131163048
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http://dx.doi.org/10.1016/j.cmet.2016.09.007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5123805PMC
October 2016

Stem Cells and Regeneration in the Digestive System: Keystone Meeting.

Gastroenterology 2016 09 29;151(3):e6-9. Epub 2016 Jul 29.

Stowers Institute for Medical Research, Kansas City, Missouri; Department of Pathology and Laboratory Medicine, University of Kansas Medical Center, Kansas City, Kansas.

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http://dx.doi.org/10.1053/j.gastro.2016.07.037DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6044286PMC
September 2016

Human islets contain four distinct subtypes of β cells.

Nat Commun 2016 07 11;7:11756. Epub 2016 Jul 11.

Oregon Stem Cell Center, Papé Family Pediatric Research Institute, Department of Pediatrics, Oregon Health and Science University, 3181 SW Sam Jackson Park Road, Portland, Oregon 97239, USA.

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http://dx.doi.org/10.1038/ncomms11756DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4942571PMC
July 2016

Age-Dependent Pancreatic Gene Regulation Reveals Mechanisms Governing Human β Cell Function.

Cell Metab 2016 05 28;23(5):909-20. Epub 2016 Apr 28.

Department of Developmental Biology, Stanford University School of Medicine, Stanford, CA 94305, USA; Department of Medicine (Oncology Division), Stanford University School of Medicine, Stanford, CA 94305, USA; Howard Hughes Medical Institute, Stanford University School of Medicine, Stanford, CA 94305, USA. Electronic address:

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http://dx.doi.org/10.1016/j.cmet.2016.04.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4864151PMC
May 2016

Stem cells versus plasticity in liver and pancreas regeneration.

Nat Cell Biol 2016 Mar;18(3):238-45

Department of Pediatrics and Cellular and Molecular Medicine, Pediatric Diabetes Research Center, Sanford Consortium for Regenerative Medicine, University of California, San Diego, La Jolla, California 92093-0695, USA.

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http://www.nature.com/articles/ncb3309
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http://dx.doi.org/10.1038/ncb3309DOI Listing
March 2016

Adeno-associated virus finds its disease.

Nat Genet 2015 Oct;47(10):1104-5

Papé Family Pediatric Research Institute, Oregon Health and Science University, Portland, Oregon, USA.

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http://dx.doi.org/10.1038/ng.3407DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4762592PMC
October 2015

Fibroblast Growth Factor Signaling Controls Liver Size in Mice With Humanized Livers.

Gastroenterology 2015 Sep 29;149(3):728-40.e15. Epub 2015 May 29.

Oregon Stem Cell Center, Oregon Health & Science Center, Portland, Oregon; Department of Hematology and Oncology, Oregon Health & Science Center, Portland, Oregon.

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http://dx.doi.org/10.1053/j.gastro.2015.05.043DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4550566PMC
September 2015

Directed differentiation of cholangiocytes from human pluripotent stem cells.

Nat Biotechnol 2015 Aug 13;33(8):853-61. Epub 2015 Jul 13.

1] Toronto General Research Institute, University Health Network, Toronto, Ontario, Canada. [2] Division of General Surgery, University Health Network, Toronto, Ontario, Canada. [3] Department of Surgery, University of Toronto, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1038/nbt.3294DOI Listing
August 2015

The Sirt1 activator SRT3025 expands hematopoietic stem and progenitor cells and improves hematopoiesis in Fanconi anemia mice.

Stem Cell Res 2015 Jul 22;15(1):130-40. Epub 2015 May 22.

Oregon Stem Cell Center, Department of Pediatrics, Oregon Health & Science University, Portland, OR 97239, USA.

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http://dx.doi.org/10.1016/j.scr.2015.05.007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4516677PMC
July 2015

Novel surface markers directed against adult human gallbladder.

Stem Cell Res 2015 Jul 11;15(1):172-81. Epub 2015 Jun 11.

Oregon Stem Cell Center, Papé Family Pediatric Research Institute, Department of Pediatrics, Oregon Health & Science University, 3181 SW Sam Jackson Park Road, Portland, OR 97239, USA. Electronic address:

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http://dx.doi.org/10.1016/j.scr.2015.06.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4516714PMC
July 2015

Bipotential adult liver progenitors are derived from chronically injured mature hepatocytes.

Cell Stem Cell 2014 Nov 9;15(5):605-18. Epub 2014 Oct 9.

Department of Pediatrics, Oregon Health & Science University, 3181 SW Sam Jackson Park Road, Portland, OR 97239, USA.

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http://dx.doi.org/10.1016/j.stem.2014.09.008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4254170PMC
November 2014

Pharmacologic inhibition of L-tyrosine degradation ameliorates cerebral dopamine deficiency in murine phenylketonuria (PKU).

J Inherit Metab Dis 2014 Sep 3;37(5):735-43. Epub 2014 Feb 3.

Department of Molecular and Medical Genetics, Oregon Health & Science University, Mailstop L-103, 3181 Sam Jackson Park Rd., Portland, OR, 97239, USA,

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http://link.springer.com/10.1007/s10545-013-9675-2
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http://dx.doi.org/10.1007/s10545-013-9675-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4119869PMC
September 2014

The organoid-initiating cells in mouse pancreas and liver are phenotypically and functionally similar.

Stem Cell Res 2014 Sep 27;13(2):275-83. Epub 2014 Jul 27.

Oregon Stem Cell Center, Oregon Health & Science University, Portland, OR 97239, USA. Electronic address:

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http://dx.doi.org/10.1016/j.scr.2014.07.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4243830PMC
September 2014

Liver stem cells, where art thou?

Authors:
Markus Grompe

Cell Stem Cell 2014 Sep;15(3):257-258

Papé Family Pediatric Research Institute, Department of Pediatrics, Oregon Stem Cell Center, L 321, Oregon Health & Science University, Portland, OR 97239, USA. Electronic address:

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http://www.cell.com/cell-stem-cell/pdf/S1934-5909(14)00342-7
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http://linkinghub.elsevier.com/retrieve/pii/S193459091400342
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http://dx.doi.org/10.1016/j.stem.2014.08.004DOI Listing
September 2014

Mice with chimeric livers are an improved model for human lipoprotein metabolism.

PLoS One 2013 4;8(11):e78550. Epub 2013 Nov 4.

Department of Clinical Science, Intervention and Technology (CLINTEC) Division of Transplantation Surgery, Karolinska Institute, Karolinska University Hospital Huddinge, Stockholm, Sweden.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0078550PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3817217PMC
August 2014

Clonal tracing of Sox9+ liver progenitors in mouse oval cell injury.

Hepatology 2014 Jul 28;60(1):278-89. Epub 2014 May 28.

Department of Cell and Developmental Biology, Oregon Health & Science University, Portland, OR.

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http://doi.wiley.com/10.1002/hep.27084
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http://dx.doi.org/10.1002/hep.27084DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4077948PMC
July 2014

Genome editing with Cas9 in adult mice corrects a disease mutation and phenotype.

Nat Biotechnol 2014 Jun 30;32(6):551-3. Epub 2014 Mar 30.

1] David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA. [2] Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA. [3] Harvard-MIT Division of Health Sciences & Technology, Cambridge, Massachusetts, USA. [4] Institute of Medical Engineering and Science, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA.

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http://dx.doi.org/10.1038/nbt.2884DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4157757PMC
June 2014

Evaluation of resveratrol and N-acetylcysteine for cancer chemoprevention in a Fanconi anemia murine model.

Pediatr Blood Cancer 2014 Apr 20;61(4):740-2. Epub 2013 Sep 20.

Oregon Stem Cell Center, Department of Pediatrics, Oregon Health and Science University, Portland, Oregon.

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http://dx.doi.org/10.1002/pbc.24780DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3946268PMC
April 2014

Selection and evaluation of clinically relevant AAV variants in a xenograft liver model.

Nature 2014 Feb 25;506(7488):382-6. Epub 2013 Dec 25.

Stanford University, School of Medicine, Departments of Pediatrics and Genetics, 269 Campus Drive, Stanford, California 94305, USA.

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http://dx.doi.org/10.1038/nature12875DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3939040PMC
February 2014

Mice with human livers.

Gastroenterology 2013 Dec 13;145(6):1209-14. Epub 2013 Sep 13.

Oregon Stem Cell Center, Department of Pediatrics, Oregon Health & Science University, Portland, Oregon. Electronic address:

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http://dx.doi.org/10.1053/j.gastro.2013.09.009DOI Listing
December 2013

Anthracyclines induce DNA damage response-mediated protection against severe sepsis.

Immunity 2013 Nov 31;39(5):874-84. Epub 2013 Oct 31.

Instituto de Medicina Molecular, Faculdade de Medicina, Universidade de Lisboa, 1649-028 Lisboa, Portugal; Clínica Universitária de Cirurgia I, Centro Hospitalar Lisboa Norte, EPE, 1649-028 Lisboa, Portugal; Gulbenkian Programme for Advanced Medical Education, 2780-156 Oeiras, Portugal; Champalimaud Foundation, 1400-038 Lisboa, Portugal.

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http://dx.doi.org/10.1016/j.immuni.2013.08.039DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3968948PMC
November 2013

Assessing the potential of induced liver regeneration.

Nat Med 2013 Sep;19(9):1096-7

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http://dx.doi.org/10.1038/nm.3325DOI Listing
September 2013

Response to "Can 'humanized' mice improve drug development in the 21st century?".

Trends Pharmacol Sci 2013 Aug 19;34(8):425. Epub 2013 Jul 19.

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http://dx.doi.org/10.1016/j.tips.2013.06.001DOI Listing
August 2013

Generation of islet-like cells from mouse gall bladder by direct ex vivo reprogramming.

Stem Cell Res 2013 Jul 18;11(1):503-15. Epub 2013 Feb 18.

Oregon Stem Cell Center, Papé Family Pediatric Research Institute, Oregon Health & Science University, Portland, OR 97203, USA.

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http://dx.doi.org/10.1016/j.scr.2013.02.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3940065PMC
July 2013

p53 regulates a mitotic transcription program and determines ploidy in normal mouse liver.

Hepatology 2013 May 15;57(5):2004-13. Epub 2013 Feb 15.

Department of Biochemistry and Molecular BiologyThe University of Texas MD Anderson Cancer Center, Houston, TX, USA.

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http://dx.doi.org/10.1002/hep.26233DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3632650PMC
May 2013

A therapy for liver failure found in the JNK yard.

Cell 2013 Apr;153(2):283-4

Department of Surgery, Eli and Edythe Broad Center of Regeneration Medicine and Stem Cell Research, and Liver Center, University of California, San Francisco, San Francisco, CA 94143, USA.

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http://dx.doi.org/10.1016/j.cell.2013.03.033DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4169283PMC
April 2013

Epigenomic plasticity enables human pancreatic α to β cell reprogramming.

J Clin Invest 2013 Mar 22;123(3):1275-84. Epub 2013 Feb 22.

Department of Genetics and Institute for Diabetes, Obesity and Metabolism, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA.

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http://dx.doi.org/10.1172/JCI66514DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3582140PMC
March 2013

Ribosomal DNA integrating rAAV-rDNA vectors allow for stable transgene expression.

Mol Ther 2012 Oct 18;20(10):1912-23. Epub 2012 Sep 18.

Stanford University, Departments of Pediatrics and Genetics, Stanford, California 94305-5164, USA.

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http://dx.doi.org/10.1038/mt.2012.164DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3464642PMC
October 2012

AAV vectors containing rDNA homology display increased chromosomal integration and transgene persistence.

Mol Ther 2012 Oct 18;20(10):1902-11. Epub 2012 Sep 18.

Oregon Stem Cell Center, Papé Family Pediatric Research Institute, Oregon Health and Science University, Portland, Oregon 97239-3098, USA.

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http://dx.doi.org/10.1038/mt.2012.157DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3464636PMC
October 2012

Aneuploidy as a mechanism for stress-induced liver adaptation.

J Clin Invest 2012 Sep 6;122(9):3307-15. Epub 2012 Aug 6.

Oregon Stem Cell Center, Papé Family Pediatric Research Institute, Portland, OR, USA.

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http://www.jci.org/articles/view/64026
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http://dx.doi.org/10.1172/JCI64026DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3428097PMC
September 2012

Intra-hematopoietic cell fusion as a source of somatic variation in the hematopoietic system.

J Cell Sci 2012 Jun 5;125(Pt 12):2837-43. Epub 2012 Mar 5.

Department of Pediatrics, Papé Family Pediatric Research Institute, Oregon Health and Science University, Portland, OR 97239-3098, USA.

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http://jcs.biologists.org/content/joces/125/12/2837.full.pdf
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http://jcs.biologists.org/cgi/doi/10.1242/jcs.100123
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http://dx.doi.org/10.1242/jcs.100123DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3434805PMC
June 2012

AAV-mediated gene targeting is significantly enhanced by transient inhibition of nonhomologous end joining or the proteasome in vivo.

Hum Gene Ther 2012 Jun 25;23(6):658-65. Epub 2012 Jun 25.

Oregon Stem Cell Center, Oregon Health and Science University, Portland, OR 97239, USA.

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http://dx.doi.org/10.1089/hum.2012.038DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3392621PMC
June 2012

Tissue stem cells: new tools and functional diversity.

Authors:
Markus Grompe

Cell Stem Cell 2012 Jun;10(6):685-689

Papé Family Pediatric Research Institute, Oregon Health & Science University, 3181 S.W. Sam Jackson Park Road, Mail Code L321, Portland, OR 97239-3098, USA. Electronic address:

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http://dx.doi.org/10.1016/j.stem.2012.04.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3940056PMC
June 2012

Frequent aneuploidy among normal human hepatocytes.

Gastroenterology 2012 Jan 2;142(1):25-8. Epub 2011 Nov 2.

Oregon Stem Cell Center, Papé Family Pediatric Research Institute, Oregon Health & Science University, Portland, Oregon, USA.

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http://dx.doi.org/10.1053/j.gastro.2011.10.029DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3244538PMC
January 2012

Efficient production of Fah-null heterozygote pigs by chimeric adeno-associated virus-mediated gene knockout and somatic cell nuclear transfer.

Hepatology 2011 Oct 9;54(4):1351-9. Epub 2011 Aug 9.

Papé Family Pediatric Research Institute & Oregon Stem Cell Center, Oregon Health & Sciences University, Portland, OR 97239, USA.

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http://dx.doi.org/10.1002/hep.24490DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3184202PMC
October 2011

Notch signaling inhibits hepatocellular carcinoma following inactivation of the RB pathway.

J Exp Med 2011 Sep 29;208(10):1963-76. Epub 2011 Aug 29.

Department of Genetics, Department of Pediatrics, Stanford University, Stanford, CA, USA; Department of Medical Chemistry, University of Liège, B-4000 Liège, Belgium.

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http://dx.doi.org/10.1084/jem.20110198DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3182062PMC
September 2011

Isolation of mouse pancreatic alpha, beta, duct and acinar populations with cell surface markers.

Mol Cell Endocrinol 2011 Jun 22;339(1-2):144-50. Epub 2011 Apr 22.

Oregon Health and Science University and Oregon Stem Cell Center, 3181 SW Sam Jackson Park Rd., Portland, OR 97239, USA.

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http://dx.doi.org/10.1016/j.mce.2011.04.008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3112273PMC
June 2011

Deficiencies in the Fanconi anemia DNA damage response pathway increase sensitivity to HPV-associated head and neck cancer.

Cancer Res 2010 Dec 8;70(23):9959-68. Epub 2010 Oct 8.

McArdle Laboratory for Cancer Research, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin, USA.

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http://dx.doi.org/10.1158/0008-5472.CAN-10-1291DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2999655PMC
December 2010

Chimeric mice with humanized liver: tools for the study of drug metabolism, excretion, and toxicity.

Methods Mol Biol 2010 ;640:491-509

Department of Pathology, University of Pittsburgh, Pittsburgh, PA, USA.

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http://dx.doi.org/10.1007/978-1-60761-688-7_27DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3136240PMC
October 2010

The ploidy conveyor of mature hepatocytes as a source of genetic variation.

Nature 2010 Oct 22;467(7316):707-10. Epub 2010 Sep 22.

Oregon Stem Cell Center, Papé Family Pediatric Research Institute, Oregon Health & Science University, Portland, Oregon 97239, USA.

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http://www.nature.com/articles/nature09414
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http://dx.doi.org/10.1038/nature09414DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2967727PMC
October 2010

Therapeutic liver reconstitution with murine cells isolated long after death.

Gastroenterology 2010 Sep 2;139(3):1019-29. Epub 2010 Jun 2.

Oregon Stem Cell Center, Oregon Health and Science University, Portland, Oregon 97239, USA.

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http://dx.doi.org/10.1053/j.gastro.2010.05.082DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3786690PMC
September 2010

Adeno-associated virus gene repair corrects a mouse model of hereditary tyrosinemia in vivo.

Hepatology 2010 Apr;51(4):1200-8

Oregon Stem Cell Center, Oregon Health and Science University, Portland, OR 97203, USA.

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http://dx.doi.org/10.1002/hep.23481DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3136243PMC
April 2010

Embryonic lethality after combined inactivation of Fancd2 and Mlh1 in mice.

Cancer Res 2009 Dec;69(24):9431-8

Oregon Stem Cell Center, Oregon Health and Science University, Portland, Oregon, USA.

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http://dx.doi.org/10.1158/0008-5472.CAN-09-2452DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2799030PMC
December 2009

CDX2 in the formation of the trophectoderm lineage in primate embryos.

Dev Biol 2009 Nov 3;335(1):179-87. Epub 2009 Sep 3.

Oregon National Primate Research Center, Oregon Health and Science University, Beaverton, OR, USA.

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http://dx.doi.org/10.1016/j.ydbio.2009.08.025DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2764001PMC
November 2009

Generation of monoclonal antibodies specific for cell surface molecules expressed on early mouse endoderm.

Stem Cells 2009 Sep;27(9):2103-13

Department of Pathology, Center for Cellular and Molecular Therapeutics; Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA.

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http://dx.doi.org/10.1002/stem.147DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2890285PMC
September 2009

Stem cells and liver regeneration.

Gastroenterology 2009 Aug 24;137(2):466-81. Epub 2009 May 24.

Oregon Stem Cell Center, Oregon Health & Science University, Portland, Oregon 97239-3098, USA.

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https://linkinghub.elsevier.com/retrieve/pii/S00165085090081
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http://dx.doi.org/10.1053/j.gastro.2009.05.044DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3136245PMC
August 2009

Validation of Fanconi anemia complementation Group A assignment using molecular analysis.

Genet Med 2009 Mar;11(3):183-92

Department of Molecular and Medical Genetics, Clinical Genetics Laboratories, Oregon Health & Science University, 3181 S.W. Sam Jackson Park Road, Portland, OR 97239, USA.

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http://dx.doi.org/10.1097/GIM.0b013e318193ba67DOI Listing
March 2009

Ploidy reductions in murine fusion-derived hepatocytes.

PLoS Genet 2009 Feb 20;5(2):e1000385. Epub 2009 Feb 20.

Oregon Stem Cell Center, Oregon Health and Science University, Portland, Oregon, United States of America.

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http://dx.doi.org/10.1371/journal.pgen.1000385DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2636893PMC
February 2009

Generation and regeneration of cells of the liver and pancreas.

Science 2008 Dec;322(5907):1490-4

Epigenetics and Progenitor Cells Program, Fox Chase Cancer Center, 333 Cottman Avenue, Philadelphia, PA 19111, USA.

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http://dx.doi.org/10.1126/science.1161431DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2641009PMC
December 2008

ERCC1 is required for FANCD2 focus formation.

Mol Genet Metab 2008 Sep-Oct;95(1-2):66-73. Epub 2008 Jul 30.

Department of Molecular and Medical Genetics, Oregon Health and Science University, Portland, OR 97239, USA.

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http://dx.doi.org/10.1016/j.ymgme.2008.06.009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2575046PMC
November 2008

Surface markers for the murine oval cell response.

Hepatology 2008 Oct;48(4):1282-91

Oregon Health & Science University and the Oregon Stem Cell Center, Portland, OR 97239, USA.

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http://dx.doi.org/10.1002/hep.22468DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3121577PMC
October 2008

Isolation of major pancreatic cell types and long-term culture-initiating cells using novel human surface markers.

Stem Cell Res 2008 Sep 8;1(3):183-94. Epub 2008 May 8.

Oregon Health & Science University, Oregon Stem Cell Center, Portland, OR 97239, USA.

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http://dx.doi.org/10.1016/j.scr.2008.04.001DOI Listing
September 2008