Markus Bohm

Markus Bohm

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Markus Bohm

Markus Bohm

Publications by authors named "Markus Bohm"

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31Publications

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Cosolvent-Enhanced Sampling and Unbiased Identification of Cryptic Pockets Suitable for Structure-Based Drug Design.

J Chem Theory Comput 2019 May 6;15(5):3331-3343. Epub 2019 May 6.

Mathematisch-Naturwissenschaftliche Fakultät, Institut für Pharmazeutische und Medizinische Chemie , Heinrich-Heine-Universität Düsseldorf , 40225 Düsseldorf , Germany.

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http://dx.doi.org/10.1021/acs.jctc.8b01295DOI Listing
May 2019

Diabetes area patent participation analysis - part II: years 2011-2016.

Expert Opin Ther Pat 2018 02 29;28(2):111-122. Epub 2017 Nov 29.

a Department of Medicinal Sciences , Worldwide Research and Development, Pfizer, Inc. , Cambridge , MA , USA.

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http://dx.doi.org/10.1080/13543776.2018.1406477DOI Listing
February 2018

Ensemble- and Rigidity Theory-Based Perturbation Approach To Analyze Dynamic Allostery.

J Chem Theory Comput 2017 Dec 27;13(12):6343-6357. Epub 2017 Nov 27.

Mathematisch-Naturwissenschaftliche Fakultät, Institut für Pharmazeutische und Medizinische Chemie, Heinrich-Heine-Universität Düsseldorf , Universitätsstr. 1, 40225 Düsseldorf, Germany.

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http://dx.doi.org/10.1021/acs.jctc.7b00529DOI Listing
December 2017

Preclinical Therapeutic Synergy of MEK1/2 and CDK4/6 Inhibition in Neuroblastoma.

Clin Cancer Res 2017 Apr 11;23(7):1785-1796. Epub 2016 Oct 11.

Division of Oncology and Center for Childhood Cancer Research, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania.

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http://dx.doi.org/10.1158/1078-0432.CCR-16-1131DOI Listing
April 2017

A Small-Molecule Anti-secretagogue of PCSK9 Targets the 80S Ribosome to Inhibit PCSK9 Protein Translation.

Cell Chem Biol 2016 Nov 13;23(11):1362-1371. Epub 2016 Oct 13.

Medicine Design, Worldwide Research & Development, Pfizer, Inc., 610 Main Street, Cambridge, MA 02139, USA. Electronic address:

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http://www.cell.com/cell-chemical-biology/pdf/S2451-9456(16)
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http://dx.doi.org/10.1016/j.chembiol.2016.08.016DOI Listing
November 2016

Patterns of HER2 Gene Amplification and Response to Anti-HER2 Therapies.

PLoS One 2015 15;10(6):e0129876. Epub 2015 Jun 15.

Preclinical Oncology Program, Vall d'Hebron Institute of Oncology (VHIO), Universitat Autònoma de Barcelona, 08035, Barcelona, Spain; Department of Biochemistry and Molecular Biology, Universitat Autònoma de Barcelona, Campus de la UAB, 08193, Bellaterra, Spain; Institució Catalana de Recerca i Estudis Avançats (ICREA), 08010, Barcelona, Spain.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0129876PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4467984PMC
March 2016

Discovery of Selective Small Molecule Inhibitors of Monoacylglycerol Acyltransferase 3.

J Med Chem 2015 Sep 8;58(18):7164-72. Epub 2015 Sep 8.

Worldwide Medicinal Chemistry, ‡Cardiovascular, Metabolic and Endocrine Diseases Research Unit, and §Pharmacokinetics, Dynamics and Metabolism, Pfizer Worldwide Research & Development , Cambridge, Massachusetts 02139, United States.

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http://dx.doi.org/10.1021/acs.jmedchem.5b01008DOI Listing
September 2015

Characterization of the novel and specific PI3Kα inhibitor NVP-BYL719 and development of the patient stratification strategy for clinical trials.

Mol Cancer Ther 2014 May 7;13(5):1117-29. Epub 2014 Mar 7.

Authors' Affiliations: Novartis Institutes for BioMedical Research, Disease Area Oncology; Novartis Institutes for BioMedical Research, Global Discovery Chemistry; Novartis Institutes for BioMedical Research, Center for Proteomic Chemistry; Novartis Pharma AG, Oncology Translational Medicine, Basel, Switzerland; Novartis Pharma AG, Oncology Translational Medicine; Novartis Institutes for BioMedical Research, Developmental and Molecular Pathways, Cambridge, Massachusetts; and Novartis Institutes for BioMedical Research, Developmental and Molecular Pathways, Shangai, China.

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http://dx.doi.org/10.1158/1535-7163.MCT-13-0865DOI Listing
May 2014

Chemical Probe Identification Platform for Orphan GPCRs Using Focused Compound Screening: GPR39 as a Case Example.

ACS Med Chem Lett 2013 Nov 16;4(11):1079-84. Epub 2013 Sep 16.

Departments of Cardiovascular, Metabolic and Endocrine Diseases and Cardiovascular, Metabolic and Endocrine Diseases Medicinal Chemistry, Pfizer Worldwide Research and Development , 620 Memorial Drive, Cambridge, Massachusetts 02139, United States.

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http://dx.doi.org/10.1021/ml400275zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4027148PMC
November 2013

Discovery of 5-phenoxy-1,3-dimethyl-1H-pyrazole-4-carboxamides as potent agonists of TGR5 via sequential combinatorial libraries.

Bioorg Med Chem Lett 2013 Mar 5;23(5):1407-11. Epub 2013 Jan 5.

Pfizer Worldwide Research & Development, Eastern Point Road, Groton, CT 06340, United States.

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http://dx.doi.org/10.1016/j.bmcl.2012.12.076DOI Listing
March 2013

Conservation and diversification of dileucine signal recognition by adaptor protein (AP) complex variants.

J Biol Chem 2011 Jan 19;286(3):2022-30. Epub 2010 Nov 19.

Cell Biology and Metabolism Program, NICHD, National Institutes of Health, Bethesda, Maryland 20892, USA.

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http://dx.doi.org/10.1074/jbc.M110.197178DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3023499PMC
January 2011

Similarity searching and scaffold hopping in synthetically accessible combinatorial chemistry spaces.

J Med Chem 2008 Apr 2;51(8):2468-80. Epub 2008 Apr 2.

Pfizer Global Research and Development, Eastern Point Road, Groton, Connecticut 06340, USA.

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http://dx.doi.org/10.1021/jm0707727DOI Listing
April 2008

An ear-core interaction regulates the recruitment of the AP-3 complex to membranes.

Dev Cell 2004 Oct;7(4):619-25

Cell Biology and Metabolism Branch, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892, USA.

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http://dx.doi.org/10.1016/j.devcel.2004.08.009DOI Listing
October 2004

Rabenosyn-5 and EHD1 interact and sequentially regulate protein recycling to the plasma membrane.

Mol Biol Cell 2004 May 12;15(5):2410-22. Epub 2004 Mar 12.

Department of Biochemistry and Molecular Biology, University of Nebraska Medical Center, Omaha, NE 68198-5870, USA.

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http://www.molbiolcell.org/doi/10.1091/mbc.e03-10-0733
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http://dx.doi.org/10.1091/mbc.e03-10-0733DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC404033PMC
May 2004

Recognition of dileucine-based sorting signals from HIV-1 Nef and LIMP-II by the AP-1 gamma-sigma1 and AP-3 delta-sigma3 hemicomplexes.

J Cell Biol 2003 Dec;163(6):1281-90

Cell Biology and Metabolism Branch, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892, USA.

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http://dx.doi.org/10.1083/jcb.200307157DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2173715PMC
December 2003

Specific regulation of the adaptor protein complex AP-3 by the Arf GAP AGAP1.

Dev Cell 2003 Sep;5(3):513-21

Laboratory of Cellular Oncology, Center for Cancer Research, National Cancer Institute, Building 37, Room 4118, Bethesda, MD 20892, USA.

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September 2003

Site-specific cross-linking reveals a differential direct interaction of class 1, 2, and 3 ADP-ribosylation factors with adaptor protein complexes 1 and 3.

Biochemistry 2002 Apr;41(14):4669-77

Secretory Pathways Laboratory, Cancer Research UK London Research Institute, 44 Lincoln's Inn Fields, London WC2A 3PX, England.

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http://dx.doi.org/10.1021/bi016064jDOI Listing
April 2002

Genetic analyses of adaptin function from yeast to mammals.

Gene 2002 Mar;286(2):175-86

Cell Biology and Metabolism Branch, National Institute of Child Health and Human Development, Building 18T/Room 101, National Institutes of Health, Bethesda, MD 20892, USA.

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http://cbmp.nichd.nih.gov/journals/Gene.3_20_02.pdf
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http://dx.doi.org/10.1016/s0378-1119(02)00422-5DOI Listing
March 2002