Markku Varjosalo

Markku Varjosalo

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Markku Varjosalo

Publications by authors named "Markku Varjosalo"

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Loss-of-function variants in TBC1D32 underlie syndromic hypopituitarism.

J Clin Endocrinol Metab 2020 Feb 15. Epub 2020 Feb 15.

Helsinki University Hospital, New Children's Hospital, Pediatric Research Center, Helsinki, Helsinki, Finland.

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http://dx.doi.org/10.1210/clinem/dgaa078DOI Listing
February 2020

PTPRA Phosphatase Regulates GDNF-Dependent RET Signaling and Inhibits the RET Mutant MEN2A Oncogenic Potential.

iScience 2020 Feb 31;23(2):100871. Epub 2020 Jan 31.

Systems Biology/Pathology Research Group and Proteomics Unit, Institute of Biotechnology, HiLIFE, University of Helsinki, Helsinki 00014, Finland. Electronic address:

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http://dx.doi.org/10.1016/j.isci.2020.100871DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7021549PMC
February 2020

Design, synthesis and characterization of a PEGylated stanozolol for potential therapeutic applications.

Int J Pharm 2020 Jan 9;573:118826. Epub 2019 Nov 9.

Department of Pharmacy, University of Chieti - Pescara "G. d'Annunzio", Via dei Vestini 31, I-66100 Chieti, Italy.

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http://dx.doi.org/10.1016/j.ijpharm.2019.118826DOI Listing
January 2020

Tropomodulins Control the Balance between Protrusive and Contractile Structures by Stabilizing Actin-Tropomyosin Filaments.

Curr Biol 2020 Jan 14. Epub 2020 Jan 14.

HiLIFE Institute of Biotechnology, University of Helsinki, PO Box 56, 00014 Helsinki, Finland. Electronic address:

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http://dx.doi.org/10.1016/j.cub.2019.12.049DOI Listing
January 2020

FGFR4 phosphorylates MST1 to confer breast cancer cells resistance to MST1/2-dependent apoptosis.

Cell Death Differ 2019 Dec 22;26(12):2577-2593. Epub 2019 Mar 22.

Department of Microbiology, Tumor and Cell Biology (MTC), Karolinska Institutet, Stockholm, SE-171 77, Sweden.

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http://dx.doi.org/10.1038/s41418-019-0321-xDOI Listing
December 2019

Gain-of-function CEBPE mutation causes noncanonical autoinflammatory inflammasomopathy.

J Allergy Clin Immunol 2019 Nov 13;144(5):1364-1376. Epub 2019 Jun 13.

Adult Immunodeficiency Unit, Infectious Diseases, Inflammation Center, University of Helsinki and Helsinki University Hospital, Helsinki, Finland; Rare Diseases Center and Pediatric Research Center, Children's Hospital, University of Helsinki and Helsinki University Hospital, Helsinki, Finland. Electronic address:

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http://dx.doi.org/10.1016/j.jaci.2019.06.003DOI Listing
November 2019

ER-Targeted Beclin 1 Supports Autophagosome Biogenesis in the Absence of ULK1 and ULK2 Kinases.

Cells 2019 05 17;8(5). Epub 2019 May 17.

Molecular and Integrative Biosciences Research Programme, University of Helsinki, 00014 Helsinki, Finland.

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http://dx.doi.org/10.3390/cells8050475DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6562811PMC
May 2019

Talin-mediated force transmission and talin rod domain unfolding independently regulate adhesion signaling.

J Cell Sci 2019 04 3;132(7). Epub 2019 Apr 3.

Faculty of Medicine and Health Technology and BioMediTech, Tampere University, Tampere 33014, Finland

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http://dx.doi.org/10.1242/jcs.226514DOI Listing
April 2019

Ribosome profiles and riboproteomes of healthy and Potato virus A- and Agrobacterium-infected Nicotiana benthamiana plants.

Mol Plant Pathol 2019 03 6;20(3):392-409. Epub 2018 Dec 6.

Department of Microbiology, Faculty of Agriculture and Forestry, University of Helsinki, PO Box 56, FI-00014, Finland.

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http://doi.wiley.com/10.1111/mpp.12764
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http://dx.doi.org/10.1111/mpp.12764DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6637900PMC
March 2019

Assembly of the β4-Integrin Interactome Based on Proximal Biotinylation in the Presence and Absence of Heterodimerization.

Mol Cell Proteomics 2019 02 7;18(2):277-293. Epub 2018 Nov 7.

From the ‡Oulu Center for Cell-Matrix Research, Biocenter Oulu, Faculty of Biochemistry and Molecular Medicine, University of Oulu, Finland;

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http://www.mcponline.org/lookup/doi/10.1074/mcp.RA118.001095
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http://dx.doi.org/10.1074/mcp.RA118.001095DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6356083PMC
February 2019

MKRN3 Interacts With Several Proteins Implicated in Puberty Timing but Does Not Influence Expression.

Front Endocrinol (Lausanne) 2019 8;10:48. Epub 2019 Feb 8.

Stem Cells and Metabolism Research Program, Faculty of Medicine, University of Helsinki, Helsinki, Finland.

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http://dx.doi.org/10.3389/fendo.2019.00048DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6375840PMC
February 2019

Myosin-18B Promotes the Assembly of Myosin II Stacks for Maturation of Contractile Actomyosin Bundles.

Curr Biol 2019 01 20;29(1):81-92.e5. Epub 2018 Dec 20.

Institute of Biotechnology, P.O. Box 56, University of Helsinki, 00014 Helsinki, Finland. Electronic address:

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http://dx.doi.org/10.1016/j.cub.2018.11.045DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6347125PMC
January 2019

Systems pathology analysis identifies neurodegenerative nature of age-related vitreoretinal interface diseases.

Aging Cell 2018 Oct 2;17(5):e12809. Epub 2018 Jul 2.

Institute of Biotechnology and Helsinki Institute of Life Science, University of Helsinki, Helsinki, Finland.

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http://dx.doi.org/10.1111/acel.12809DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6156470PMC
October 2018

Redox regulation of GRPEL2 nucleotide exchange factor for mitochondrial HSP70 chaperone.

Redox Biol 2018 10 4;19:37-45. Epub 2018 Aug 4.

Research Programs Unit, Molecular Neurology, University of Helsinki, Helsinki, Finland; Department of Medical and Clinical Genetics, University of Helsinki, Helsinki, Finland. Electronic address:

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http://dx.doi.org/10.1016/j.redox.2018.07.024DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6089081PMC
October 2018

Molecular Atlas of Postnatal Mouse Heart Development.

J Am Heart Assoc 2018 10;7(20):e010378

1 Drug Research Program and Division of Pharmacology and Pharmacotherapy Faculty of Pharmacy University of Helsinki Finland.

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http://dx.doi.org/10.1161/JAHA.118.010378DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6474944PMC
October 2018

UNC-45a promotes myosin folding and stress fiber assembly.

J Cell Biol 2017 12 20;216(12):4053-4072. Epub 2017 Oct 20.

Institute of Biotechnology, University of Helsinki, Helsinki, Finland

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http://dx.doi.org/10.1083/jcb.201703107DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5716280PMC
December 2017

Candidate proteins from predegenerated nerve exert time-specific protection of retinal ganglion cells in glaucoma.

Sci Rep 2017 11 6;7(1):14540. Epub 2017 Nov 6.

Chair and Department of Physiology, School of Medicine in Katowice, Medical University of Silesia, Medykow 18, 40-752, Katowice, Poland.

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http://dx.doi.org/10.1038/s41598-017-14860-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5673995PMC
November 2017

PWP1 Mediates Nutrient-Dependent Growth Control through Nucleolar Regulation of Ribosomal Gene Expression.

Dev Cell 2017 10;43(2):240-252.e5

Department of Biosciences, University of Helsinki, 00790 Helsinki, Finland; Institute of Biotechnology, University of Helsinki, 00790 Helsinki, Finland. Electronic address:

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http://dx.doi.org/10.1016/j.devcel.2017.09.022DOI Listing
October 2017

Damaging heterozygous mutations in NFKB1 lead to diverse immunologic phenotypes.

J Allergy Clin Immunol 2017 Sep 21;140(3):782-796. Epub 2017 Jan 21.

Adult Immunodeficiency Unit, Infectious Diseases, Inflammation Center, University of Helsinki and Helsinki University Hospital, Helsinki, Finland; Rare Diseases Center, Children's Hospital, University of Helsinki and Helsinki University Hospital, Helsinki, Finland.

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http://dx.doi.org/10.1016/j.jaci.2016.10.054DOI Listing
September 2017

Agonist-specific Protein Interactomes of Glucocorticoid and Androgen Receptor as Revealed by Proximity Mapping.

Mol Cell Proteomics 2017 08 13;16(8):1462-1474. Epub 2017 Jun 13.

From the ‡Institute of Biomedicine, University of Eastern Finland, Kuopio, Finland;

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http://dx.doi.org/10.1074/mcp.M117.067488DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5546198PMC
August 2017

Combined immunodeficiency and hypoglycemia associated with mutations in hypoxia upregulated 1.

J Allergy Clin Immunol 2017 04 29;139(4):1391-1393.e11. Epub 2016 Nov 29.

Department of Biosciences and Nutrition, Karolinska Institutet, Huddinge, Sweden; Folkhälsan Institute of Genetics, Folkhälsan Research Center, Helsinki, Finland; Research Programs Unit, Molecular Neurology, University of Helsinki, Helsinki, Finland; Center for Innovative Medicine, Karolinska Institutet, Huddinge, Sweden.

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http://dx.doi.org/10.1016/j.jaci.2016.09.050DOI Listing
April 2017

Systematic Analysis of Human Protein Phosphatase Interactions and Dynamics.

Cell Syst 2017 04 18;4(4):430-444.e5. Epub 2017 Mar 18.

Institute of Biotechnology, University of Helsinki, Helsinki 00014, Finland. Electronic address:

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http://dx.doi.org/10.1016/j.cels.2017.02.011DOI Listing
April 2017

An Activating STAT3 Mutation Causes Neonatal Diabetes through Premature Induction of Pancreatic Differentiation.

Cell Rep 2017 04;19(2):281-294

Research Programs Unit, Molecular Neurology and Biomedicum Stem Cell Centre, Faculty of Medicine, University of Helsinki, 00014 Helsinki, Finland; Children's Hospital, University of Helsinki and Helsinki University Hospital, 00290 Helsinki, Finland. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2017.03.055DOI Listing
April 2017

Several Hfq-dependent alterations in physiology of Yersinia enterocolitica O:3 are mediated by derepression of the transcriptional regulator RovM.

Mol Microbiol 2017 03 23;103(6):1065-1091. Epub 2017 Jan 23.

Department of Bacteriology and Immunology, Medicum, Research Programs Unit, Immunobiology, University of Helsinki, Finland.

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http://dx.doi.org/10.1111/mmi.13610DOI Listing
March 2017

Role for formin-like 1-dependent acto-myosin assembly in lipid droplet dynamics and lipid storage.

Nat Commun 2017 03 31;8:14858. Epub 2017 Mar 31.

Department of Anatomy and Research Programs Unit, Faculty of Medicine, University of Helsinki, Helsinki 00290, Finland.

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http://dx.doi.org/10.1038/ncomms14858DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5380971PMC
March 2017

A proteomics view on integrin-mediated adhesions.

Proteomics 2017 02 14;17(3-4). Epub 2016 Dec 14.

Institute of Biotechnology, Biocenter 3, University of Helsinki, Helsinki, Finland.

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http://dx.doi.org/10.1002/pmic.201600022DOI Listing
February 2017

Protein composition of 6K2-induced membrane structures formed during Potato virus A infection.

Mol Plant Pathol 2016 08 17;17(6):943-58. Epub 2016 Feb 17.

Department of Food and Environmental Sciences, Viikki Plant Science Centre, 00014 University of Helsinki, Finland.

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http://dx.doi.org/10.1111/mpp.12341DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6638329PMC
August 2016

Predegenerated Schwann cells--a novel prospect for cell therapy for glaucoma: neuroprotection, neuroregeneration and neuroplasticity.

Sci Rep 2016 Apr 1;6:23187. Epub 2016 Apr 1.

Chair and Department of Physiology, School of Medicine in Katowice, Medical University of Silesia, Medykow 18, 40-752 Katowice, Poland.

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http://dx.doi.org/10.1038/srep23187DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4817039PMC
April 2016

Molecular insights into the function of the viral RNA silencing suppressor HCPro.

Plant J 2016 Jan;85(1):30-45

Department of Food and Environmental Sciences, Viikki Plant Science Centre, University of Helsinki, Helsinki, 00014, Finland.

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http://dx.doi.org/10.1111/tpj.13088DOI Listing
January 2016

Quantitative Proteomics Analysis of Vitreous Humor from Diabetic Retinopathy Patients.

J Proteome Res 2015 Dec 30;14(12):5131-43. Epub 2015 Oct 30.

Molecular Systems Biology Research Group, Institute of Biotechnology, University of Helsinki , FI-00014 Helsinki, Finland.

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http://dx.doi.org/10.1021/acs.jproteome.5b00900DOI Listing
December 2015

Complement Factor H Binds to Human Serum Apolipoprotein E and Mediates Complement Regulation on High Density Lipoprotein Particles.

J Biol Chem 2015 Nov 14;290(48):28977-87. Epub 2015 Oct 14.

From the Department of Bacteriology and Immunology, Haartman Institute, and Research Programs Unit, Immunobiology, University of Helsinki, FIN-00014 Helsinki, Finland.

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http://dx.doi.org/10.1074/jbc.M115.669226DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4661410PMC
November 2015

Navigating through metaproteomics data: a logbook of database searching.

Proteomics 2015 Oct 27;15(20):3439-53. Epub 2015 Apr 27.

Department of Biochemistry, Ghent University, Ghent, Belgium.

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http://dx.doi.org/10.1002/pmic.201400560DOI Listing
October 2015

Rho-kinase inhibitor Y-27632 increases cellular proliferation and migration in human foreskin fibroblast cells.

Proteomics 2015 Sep 15;15(17):2953-65. Epub 2015 Jun 15.

Department of Integrative Medical Biology, University of Umeå, Umeå, Sweden.

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http://dx.doi.org/10.1002/pmic.201400417DOI Listing
September 2015

Expression of the Yersinia enterocolitica O:3 LPS O-antigen and outer core gene clusters is RfaH-dependent.

Microbiology 2015 Jun 23;161(6):1282-94. Epub 2015 Jun 23.

1Department of Bacteriology and Immunology, Research Programs Unit, Immunobiology, University of Helsinki, Helsinki, Finland 5Helsinki University Hospital, Helsinki, Finland.

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http://www.microbiologyresearch.org/content/journal/micro/10
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http://dx.doi.org/10.1099/mic.0.000076DOI Listing
June 2015

Bidirectional Interplay between Vimentin Intermediate Filaments and Contractile Actin Stress Fibers.

Cell Rep 2015 Jun 28;11(10):1511-8. Epub 2015 May 28.

Institute of Biotechnology, P.O. Box 56, 00014 University of Helsinki, Helsinki, Finland. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2015.05.008DOI Listing
June 2015

Absence of YbeY RNase compromises the growth and enhances the virulence plasmid gene expression of Yersinia enterocolitica O:3.

Microbiology 2015 Feb 21;161(Pt 2):285-299. Epub 2014 Nov 21.

Helsinki University Central Hospital Laboratory Diagnostics, Helsinki, Finland.

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http://dx.doi.org/10.1099/mic.0.083097-0DOI Listing
February 2015

Interaction proteome of human Hippo signaling: modular control of the co-activator YAP1.

Mol Syst Biol 2013 22;9:713. Epub 2013 Dec 22.

Institute of Molecular Systems Biology, ETH Zürich, Zürich, Switzerland.

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http://dx.doi.org/10.1002/msb.201304750DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4019981PMC
June 2014

Uterine leiomyoma-linked MED12 mutations disrupt mediator-associated CDK activity.

Cell Rep 2014 May 18;7(3):654-60. Epub 2014 Apr 18.

Department of Molecular Medicine, Institute of Biotechnology, University of Texas Health Science Center at San Antonio, 7703 Floyd Curl Drive, Mail Code 8257, STRF, San Antonio, TX 78229-3900, USA. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2014.03.047DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4041330PMC
May 2014

Protein secretome of moss plants (Physcomitrella patens) with emphasis on changes induced by a fungal elicitor.

J Proteome Res 2014 Feb 6;13(2):447-59. Epub 2013 Dec 6.

Department of Agricultural Sciences, University of Helsinki , PO Box 27, FI-00014 Helsinki, Finland.

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http://dx.doi.org/10.1021/pr400827aDOI Listing
February 2014

Recognition of malondialdehyde-modified proteins by the C terminus of complement factor H is mediated via the polyanion binding site and impaired by mutations found in atypical hemolytic uremic syndrome.

J Biol Chem 2014 Feb 16;289(7):4295-306. Epub 2013 Dec 16.

From the Department of Bacteriology and Immunology, Haartman Institute, and Research Programs Unit, Immunobiology, University of Helsinki, FIN-00290 Helsinki, Finland.

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http://dx.doi.org/10.1074/jbc.M113.527416DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3924292PMC
February 2014

Isolation, characterization and complete genome sequence of PhaxI: a phage of Escherichia coli O157 : H7.

Microbiology 2013 Aug 15;159(Pt 8):1629-1638. Epub 2013 May 15.

Department of Pharmaceutical Biotechnology and Biotechnology Research Center, Faculty of Pharmacy, Tehran University of Medical Sciences, PO Box 14155-6451, Tehran, Iran.

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http://mic.microbiologyresearch.org/content/journal/micro/10
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http://dx.doi.org/10.1099/mic.0.063776-0DOI Listing
August 2013

Interlaboratory reproducibility of large-scale human protein-complex analysis by standardized AP-MS.

Nat Methods 2013 Apr 3;10(4):307-14. Epub 2013 Mar 3.

Department of Biology, Institute of Molecular Systems Biology, ETH Zurich, Zurich, Switzerland.

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http://dx.doi.org/10.1038/nmeth.2400DOI Listing
April 2013

The protein interaction landscape of the human CMGC kinase group.

Cell Rep 2013 Apr 18;3(4):1306-20. Epub 2013 Apr 18.

Department of Biology, Institute of Molecular Systems Biology, ETH Zurich, 8093 Zurich, Switzerland.

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http://dx.doi.org/10.1016/j.celrep.2013.03.027DOI Listing
April 2013

EphA2 cleavage by MT1-MMP triggers single cancer cell invasion via homotypic cell repulsion.

J Cell Biol 2013 Apr;201(3):467-84

Research Programs Unit, Genome-Scale Biology, Haartman Institute, Biomedicum Helsinki, University of Helsinki, FI-00014 Helsinki, Finland.

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http://dx.doi.org/10.1083/jcb.201205176DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3639392PMC
April 2013

Fibroblast growth factor receptor 4 regulates tumor invasion by coupling fibroblast growth factor signaling to extracellular matrix degradation.

Cancer Res 2010 Oct 28;70(20):7851-61. Epub 2010 Sep 28.

Molecular Cancer Biology Research Program, Departments of Pathology and Virology, Haartman Institute, Helsinki, Finland.

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http://dx.doi.org/10.1158/0008-5472.CAN-10-1223DOI Listing
October 2010

FGF receptor-4 (FGFR4) polymorphism acts as an activity switch of a membrane type 1 matrix metalloproteinase-FGFR4 complex.

Proc Natl Acad Sci U S A 2010 Sep 23;107(36):15786-91. Epub 2010 Aug 23.

Department of Pathology, Haartman Institute, University of Helsinki, Helsinki University Central Hospital, Finland.

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http://dx.doi.org/10.1073/pnas.0914459107DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2936587PMC
September 2010

Genome-wide analysis of ETS-family DNA-binding in vitro and in vivo.

EMBO J 2010 Jul 1;29(13):2147-60. Epub 2010 Jun 1.

Public Health Genomics Unit, National Institute for Health and Welfare (THL) and Genome-Scale Biology Program, Institute of Biomedicine and High Throughput Center, University of Helsinki, Biomedicum, Helsinki, Finland.

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http://dx.doi.org/10.1038/emboj.2010.106DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2905244PMC
July 2010

KSHV reactivation from latency requires Pim-1 and Pim-3 kinases to inactivate the latency-associated nuclear antigen LANA.

PLoS Pathog 2009 Mar 6;5(3):e1000324. Epub 2009 Mar 6.

Genome-Scale Biology Program, Institute of Biomedicine, Biomedicum Helsinki, University of Helsinki, Helsinki, Finland.

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http://dx.doi.org/10.1371/journal.ppat.1000324DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2648312PMC
March 2009

Hedgehog: functions and mechanisms.

Genes Dev 2008 Sep;22(18):2454-72

Department of Molecular Medicine, National Public Health Institute (KTL), and Genome-Scale Biology Program, Biomedicum Helsinki, Institute of Biomedicine and High Throughput Center, Faculty of Medicine, University of Helsinki, Helsinki FI-00014, Finland.

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http://dx.doi.org/10.1101/gad.1693608DOI Listing
September 2008

Hedgehog signaling.

J Cell Sci 2007 Jan;120(Pt 1):3-6

Institute of Biomedicine and High Throughput Center, and Department of Molecular Medicine, National Public Health Institute (KTL), Biomedicum, P.O. Box 63 (Haartmaninkatu 8), FIN-00014 University of Helsinki, Finland.

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http://dx.doi.org/10.1242/jcs.03309DOI Listing
January 2007

Human receptors patched and smoothened partially transduce hedgehog signal when expressed in Drosophila cells.

J Biol Chem 2006 Sep 25;281(39):28584-95. Epub 2006 Jul 25.

Laboratoire de Physiologie Cellulaire et Moléculaire, CNRS Unité Mixte de Recherche (UMR) 6548, Université de Nice-Sophia Antipolis, Parc Valrose 06108 Nice Cedex 2, France.

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http://dx.doi.org/10.1074/jbc.M512986200DOI Listing
September 2006

Divergence of hedgehog signal transduction mechanism between Drosophila and mammals.

Dev Cell 2006 Feb;10(2):177-86

Molecular and Cancer Biology Program, Biomedicum, University of Helsinki and Department of Molecular Medicine, National Public Health Institute, P.O. Box 63, Helsinki FIN-00014, Finland.

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http://dx.doi.org/10.1016/j.devcel.2005.12.014DOI Listing
February 2006

Identification of pathways regulating cell size and cell-cycle progression by RNAi.

Nature 2006 Feb;439(7079):1009-13

Molecular and Cancer Biology Program, Biomedicum Helsinki, PO Box 63 (Haartmaninkatu 8), FI-00014 University of Helsinki, Finland.

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http://dx.doi.org/10.1038/nature04469DOI Listing
February 2006