Mark Wunderlich

Mark Wunderlich

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Mark Wunderlich

Mark Wunderlich

Publications by authors named "Mark Wunderlich"

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Improved multilineage human hematopoietic reconstitution and function in NSGS mice.

PLoS One 2018 12;13(12):e0209034. Epub 2018 Dec 12.

Division of Experimental Hematology and Cancer Biology, Cancer and Blood Disease Institute, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0209034PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6291127PMC
May 2019

Small-Molecule Targeting of Oncogenic FTO Demethylase in Acute Myeloid Leukemia.

Cancer Cell 2019 Apr;35(4):677-691.e10

State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China; University of the Chinese Academy of Sciences, Beijing 100049, China. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S15356108193015
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http://dx.doi.org/10.1016/j.ccell.2019.03.006DOI Listing
April 2019

Comparative utility of NRG and NRGS mice for the study of normal hematopoiesis, leukemogenesis, and therapeutic response.

Exp Hematol 2018 11 17;67:18-31. Epub 2018 Aug 17.

Department of Pharmacology and Toxicology, University of Louisville, Louisville, KY, USA; James Graham Brown Cancer Center, University of Louisville, Louisville, KY, USA; Department of Medicine, University of Louisville, Louisville, KY, USA. Electronic address:

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http://dx.doi.org/10.1016/j.exphem.2018.08.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6200600PMC
November 2018

A non-myeloablative conditioning approach for long-term engraftment of human and mouse hematopoietic stem cells.

Leukemia 2018 09 29;32(9):2041-2046. Epub 2018 Jun 29.

Cancer and Blood Diseases Institute, Molecular and Developmental Biology Graduate Program, Children's Hospital Research Foundation, 3333 Burnet Avenue, Cincinnati, OH, 45229, USA.

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http://dx.doi.org/10.1038/s41375-018-0200-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6128741PMC
September 2018

R-2HG Exhibits Anti-tumor Activity by Targeting FTO/mA/MYC/CEBPA Signaling.

Cell 2018 01 14;172(1-2):90-105.e23. Epub 2017 Dec 14.

Department of Cancer Biology, University of Cincinnati, Cincinnati, OH 45219, USA; Gehr Family Center for Leukemia Research, City of Hope, 1500 E. Duarte Rd., Duarte, CA 91010, USA. Electronic address:

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http://dx.doi.org/10.1016/j.cell.2017.11.031DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5766423PMC
January 2018

Autophagy is dispensable for Kmt2a/Mll-Mllt3/Af9 AML maintenance and anti-leukemic effect of chloroquine.

Autophagy 2017 May 15;13(5):955-966. Epub 2017 Feb 15.

a Division of Experimental Hematology and Cancer Biology , Cincinnati Children's Research Foundation , Cincinnati , OH , USA.

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http://dx.doi.org/10.1080/15548627.2017.1287652DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5446057PMC
May 2017

MISTRG extends PDX modeling to favorable AMLs.

Blood 2016 10;128(17):2111-2112

CINCINNATI CHILDREN'S HOSPITAL MEDICAL CENTER.

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http://dx.doi.org/10.1182/blood-2016-09-738757DOI Listing
October 2016

Supraphysiologic levels of the AML1-ETO isoform AE9a are essential for transformation.

Proc Natl Acad Sci U S A 2016 08 25;113(32):9075-80. Epub 2016 Jul 25.

Division of Experimental Hematology and Cancer Biology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229;

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http://dx.doi.org/10.1073/pnas.1524225113DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4987773PMC
August 2016

Immortalization of human AE pre-leukemia cells by hTERT allows leukemic transformation.

Oncotarget 2016 Aug;7(35):55939-55950

Cancer and Blood Disease Institute, Cincinnati Children's Hospital Research Center, Cincinnati, OH, USA.

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http://dx.doi.org/10.18632/oncotarget.11093DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5302887PMC
August 2016

A ROS-Activatable Agent Elicits Homologous Recombination DNA Repair and Synergizes with Pathway Compounds.

Chembiochem 2015 Nov 2;16(17):2513-21. Epub 2015 Nov 2.

Department of Chemistry, University of Cincinnati, 404 Crosley Tower, Cincinnati, OH, 45221-0172, USA.

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http://dx.doi.org/10.1002/cbic.201500304DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4758217PMC
November 2015

Xenograft models for normal and malignant stem cells.

Blood 2015 Apr 11;125(17):2630-40. Epub 2015 Mar 11.

Division of Experimental Hematology and Cancer Biology, Cincinnati Children's Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, OH.

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http://dx.doi.org/10.1182/blood-2014-11-570218DOI Listing
April 2015

Design of a hydrogen peroxide-activatable agent that specifically targets cancer cells.

Bioorg Med Chem 2014 Dec 30;22(24):6885-92. Epub 2014 Oct 30.

Department of Chemistry, University of Cincinnati, Cincinnati, OH 45221-0172, United States.

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http://dx.doi.org/10.1016/j.bmc.2014.10.029DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4292800PMC
December 2014

OKT3 prevents xenogeneic GVHD and allows reliable xenograft initiation from unfractionated human hematopoietic tissues.

Blood 2014 Jun 28;123(24):e134-44. Epub 2014 Apr 28.

Division of Experimental Hematology and Cancer Biology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH; and.

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http://dx.doi.org/10.1182/blood-2014-02-556340DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4055932PMC
June 2014

The rate of spontaneous mutations in human myeloid cells.

Mutat Res 2013 Sep 6;749(1-2):49-57. Epub 2013 Jun 6.

Division of Hematology, Department of Veterans Affairs New York Harbor Healthcare System, United States; Division of Hematology, Department of Medicine, NYU School of Medicine and the NYU Langone Cancer Center, United States. Electronic address:

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http://dx.doi.org/10.1016/j.mrfmmm.2013.05.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4524336PMC
September 2013

Transcription factor RUNX1 promotes survival of acute myeloid leukemia cells.

J Clin Invest 2013 Sep 27;123(9):3876-88. Epub 2013 Aug 27.

Division of Experimental Hematology and Cancer Biology, Cincinnati Children's Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, Ohio 45229, USA.

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http://dx.doi.org/10.1172/JCI68557DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3754260PMC
September 2013

Novel ROS-activated agents utilize a tethered amine to selectively target acute myeloid leukemia.

Bioorg Med Chem Lett 2013 May 26;23(10):2951-4. Epub 2013 Mar 26.

Department of Chemistry, University of Cincinnati, Cincinnati, OH 45221-0172, United States.

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http://dx.doi.org/10.1016/j.bmcl.2013.03.048DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3677216PMC
May 2013

AML cells are differentially sensitive to chemotherapy treatment in a human xenograft model.

Blood 2013 Mar 24;121(12):e90-7. Epub 2013 Jan 24.

Division of Experimental Hematology, University of Cincinnati College of Medicine, Cincinnati, OH, USA.

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http://dx.doi.org/10.1182/blood-2012-10-464677DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3606073PMC
March 2013

The thrombopoietin/MPL/Bcl-xL pathway is essential for survival and self-renewal in human preleukemia induced by AML1-ETO.

Blood 2012 Jul 14;120(4):709-19. Epub 2012 Feb 14.

Divisions of Experimental Hematology and Cancer Biology, Cincinnati Children’s Hospital Medical Center, Cincinnati, OH, USA.

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http://dx.doi.org/10.1182/blood-2012-01-403212DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3412344PMC
July 2012

N-Ras(G12D) induces features of stepwise transformation in preleukemic human umbilical cord blood cultures expressing the AML1-ETO fusion gene.

Blood 2011 Feb 3;117(7):2237-40. Epub 2011 Jan 3.

Division of Experimental Hematology and Cancer Biology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA.

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http://dx.doi.org/10.1182/blood-2010-01-264119DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3062331PMC
February 2011

Model systems for examining effects of leukemia-associated oncogenes in primary human CD34+ cells via retroviral transduction.

Methods Mol Biol 2009 ;538:263-85

Division of Experimental Hematology, Cincinnati Children's Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, OH, USA.

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http://dx.doi.org/10.1007/978-1-59745-418-6_13DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2825883PMC
May 2009

Transforming human blood stem and progenitor cells: a new way forward in leukemia modeling.

Cell Cycle 2008 Nov 8;7(21):3314-9. Epub 2008 Nov 8.

Division of Experimental Hematology and Cancer Biology, Cincinnati Children's Hospital Medical Center, University of Cincinnati College of Medicine, University of Cincinnati, Cincinnati, Ohio 45229, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2812025PMC
http://dx.doi.org/10.4161/cc.7.21.6951DOI Listing
November 2008

Microenvironment determines lineage fate in a human model of MLL-AF9 leukemia.

Cancer Cell 2008 Jun;13(6):483-95

Division of Experimental Hematology, Cincinnati Children's Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, OH 45229, USA.

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http://dx.doi.org/10.1016/j.ccr.2008.04.020DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2486365PMC
June 2008

p53 signaling in response to increased DNA damage sensitizes AML1-ETO cells to stress-induced death.

Blood 2008 Feb 1;111(4):2190-9. Epub 2007 Nov 1.

Division of Experimental Hematology, Cincinnati Children's Hospital Medical Center, University of Cincinnati College of Medicine, OH 45226, USA.

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http://dx.doi.org/10.1182/blood-2007-06-093682DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2234055PMC
February 2008

Human CD34+ cells expressing the inv(16) fusion protein exhibit a myelomonocytic phenotype with greatly enhanced proliferative ability.

Blood 2006 Sep 2;108(5):1690-7. Epub 2006 May 2.

Division of Experimental Hematology, Cincinnati Children's Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, OH 45226, USA.

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http://dx.doi.org/10.1182/blood-2005-12-012773DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1586104PMC
September 2006

AML1-ETO fusion protein up-regulates TRKA mRNA expression in human CD34+ cells, allowing nerve growth factor-induced expansion.

Proc Natl Acad Sci U S A 2005 Mar 24;102(11):4016-21. Epub 2005 Feb 24.

Division of Experimental Hematology, Cincinnati Children's Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, OH 45229, USA.

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http://dx.doi.org/10.1073/pnas.0404701102DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC554792PMC
March 2005

MdmX represses E2F1 transactivation.

Cell Cycle 2004 Apr 1;3(4):472-8. Epub 2004 Apr 1.

Wright State University, Department of Biochemistry & Molecular Biology, Dayton, Ohio 45435, USA.

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April 2004

Cardiopulmonary bypass reduction of bronchial blood flow: a potential mechanism for lung injury in a neonatal pig model.

J Thorac Cardiovasc Surg 2002 Jun;123(6):1199-205

Department of Cardiovascular Surgery, Albert-Ludwigs-University, Freiburg, Germany.

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http://dx.doi.org/10.1067/mtc.2002.121977DOI Listing
June 2002

Mdm2 inhibition of p53 induces E2F1 transactivation via p21.

Oncogene 2002 Jun;21(28):4414-21

Wright State University, Department of Biochemistry and Molecular Biology, 3640 Colonel Glenn Hywy, Dayton, Ohio 45435, USA.

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http://dx.doi.org/10.1038/sj.onc.1205541DOI Listing
June 2002