Publications by authors named "Mark W Wurster"

3 Publications

  • Page 1 of 1

Personalized healthcare in clotting disorders.

Per Med 2010 Jan;7(1):65-73

In terms of managing thrombotic disorders, genotype-based individualized patient care emerged as early as 1994 when the association of factor V Leiden (G1691A), and later, prothrombin (G20210A), with thrombotic phenotypes were discovered. Since then, genetic tests for specific thrombophilic SNPs have been routinely incorporated into daily practices in both thrombotic risk assessment and clinical decision-making with respect to prophylactic anti-thrombotic therapy. Recently, the area of pharmacogenomics in major anti-thrombotic drugs, such as warfarin and clopidogrel, has been the principal driver for personalized therapy based on one's own individual characteristics.
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http://dx.doi.org/10.2217/pme.09.67DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2824443PMC
January 2010

Social and ethical controversies in thrombophilia testing and update on genetic risk factors for venous thromboembolism.

Semin Thromb Hemost 2008 Sep 28;34(6):549-61. Epub 2008 Nov 28.

Center for Molecular and Human Genetics, The Research Institute at Nationwide Children's Hospital, Columbus, Ohio 43205, USA.

Over the past 20 years, the landscape with respect to evaluation of thrombophilia, the inherited or acquired tendency to develop venous thromboembolism, has changed dramatically. Increased knowledge regarding the contribution of genetic predisposition to thrombosis has raised several questions regarding screening, diagnosis, and management. In this review, we will examine these issues while providing an update on genetic testing for inherited thrombotic disorders.
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http://dx.doi.org/10.1055/s-0028-1103366DOI Listing
September 2008

Patient self-testing for management of anticoagulation therapy: challenges.

Authors:
Mark W Wurster

J Thromb Thrombolysis 2008 Feb 27;25(1):16-7. Epub 2007 Sep 27.

OSU Internal Medicine, Ohio State University Medical Center, Columbus, OH 43210, USA.

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http://dx.doi.org/10.1007/s11239-007-0097-6DOI Listing
February 2008