Mark W Parsons

Mark W Parsons

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Mark W Parsons

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Comparing mismatch strategies for patients being considered for ischemic stroke tenecteplase trials.

Int J Stroke 2019 Nov 4:1747493019884529. Epub 2019 Nov 4.

Department of Medicine and Neurology, Royal Melbourne Hospital, University of Melbourne, Melbourne, Australia.

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http://dx.doi.org/10.1177/1747493019884529DOI Listing
November 2019

Dynamic CT but Not Optimized Multiphase CT Angiography Accurately Identifies CT Perfusion Target Mismatch Ischemic Stroke Patients.

Front Neurol 2019 23;10:1130. Epub 2019 Oct 23.

Department of Neurology, The Royal Melbourne Hospital, University of Melbourne, Melbourne, VIC, Australia.

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http://dx.doi.org/10.3389/fneur.2019.01130DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6819495PMC
October 2019

Determining the optimal dose of tenecteplase before endovascular therapy for ischemic stroke (EXTEND-IA TNK Part 2): A multicenter, randomized, controlled study.

Int J Stroke 2019 Sep 30:1747493019879652. Epub 2019 Sep 30.

Department of Medicine and Neurology, Melbourne Brain Centre at the Royal Melbourne Hospital, University of Melbourne, Victoria, Australia.

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http://dx.doi.org/10.1177/1747493019879652DOI Listing
September 2019

Exploring the relationship between ischemic core volume and clinical outcomes after thrombectomy or thrombolysis.

Neurology 2019 Jul 17;93(3):e283-e292. Epub 2019 Jun 17.

From the Department of Neurology (C.C., C.R.L., N.J.S., F.M., L.L.), John Hunter Hospital; University of Newcastle (C.C., C.R.L., N.J.S., F.M., L.L.); Hunter Medical Research Institute (C.C., C.R.L., N.J.S., F.M., L.L.), Newcastle; Department of Neurology (M.W.P., A.B.), Royal Melbourne Hospital, Melbourne Brain Centre, University of Melbourne, Australia; Department of Neurology (X.C., Q.D.), Huashan Hospital, Fudan University, Shanghai; Department of Neurology (M.L.), Second Affiliated Hospital of Zhejiang University, Hangzhou, China; Department of Neurology (T.K.), Royal Adelaide Hospital, Australia; and Division of Neurology (K.B.), Department of Medicine, University of Alberta, Edmonton, Canada.

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http://dx.doi.org/10.1212/WNL.0000000000007768DOI Listing
July 2019

Modafinil treatment modulates functional connectivity in stroke survivors with severe fatigue.

Sci Rep 2019 Jul 4;9(1):9660. Epub 2019 Jul 4.

Department of Neurology, Royal Melbourne Hospital, University of Melbourne, Melbourne, Australia.

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http://dx.doi.org/10.1038/s41598-019-46149-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6609702PMC
July 2019

Influence of occlusion site and baseline ischemic core on outcome in patients with ischemic stroke.

Neurology 2019 Jun 1;92(23):e2626-e2643. Epub 2019 May 1.

From the Department of Neurology (H.T., M.W.P., C.R.L., L.L., N.J.S., A.B.), John Hunter Hospital, University of Newcastle, Australia; Department of Medical Imaging, Division of Neuroradiology (R.I.A.), Sunnybrook Health Sciences Center and University of Toronto; Division of Neurology, Department of Medicine (K.S.B.), University of Alberta, Edmonton, Canada; Department of Neurology (M.L.), the Second Affiliated Hospital of Zhejiang University, Hangzhou, China; and Department of Neurology (T.J.K.), Royal Adelaide Hospital, Australia.

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http://dx.doi.org/10.1212/WNL.0000000000007553DOI Listing
June 2019

Artificial Neural Network Computer Tomography Perfusion Prediction of Ischemic Core.

Stroke 2019 Jun 16;50(6):1578-1581. Epub 2019 May 16.

Department of Neurology and Neurological Sciences, Stanford Stroke Center, Stanford University Medical Center, CA (S.C., G.W.A., M.G.L.).

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http://dx.doi.org/10.1161/STROKEAHA.118.022649DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6538437PMC
June 2019

Thrombolysis Guided by Perfusion Imaging up to 9 Hours after Onset of Stroke.

N Engl J Med 2019 05;380(19):1795-1803

From Florey Institute of Neuroscience and Mental Health (H.M., L. Churilov, N.Y., V.T., L. Carey, A.M., G.A.D.), the Department of Medicine and Neurology, Melbourne Brain Centre at the Royal Melbourne Hospital (B.C.V.C., M.W.P., L. Churilov, S. Christensen, N.Y., G.S., A.B., B.Y., A.M., S.M.D., G.A.D.), and the Department of Radiology, Royal Melbourne Hospital (P.M.D., B.Y., P.J.M.), University of Melbourne, Parkville, the Department of Medicine, School of Clinical Science, Monash University, Clayton (H.M., T.G.P.), the Departments of Medicine and Neurology, Melbourne Medical School, University of Melbourne and Western Health, Sunshine Hospital, St. Albans (T.W.), the Department of Neurosciences, Eastern Health and Eastern Health Clinical School, Monash University, Box Hill (H.M.D., C.F.B.), the Department of Neurology, University Hospital Geelong, Deakin University, Geelong (B.C.), the Department of Neurology, Austin Hospital, Austin Health, Heidelberg (V.T.), and Occupational Therapy, School of Allied Health, College of Science, Health and Engineering, La Trobe University, Bundoora (L. Carey), VIC, the Department of Neurology, Priority Research Centre for Brain and Mental Health Research, John Hunter Hospital (C.R.L., F.M.), University of Newcastle (J.S.), Newcastle, the Department of Neurology, Westmead Hospital (N.M.), the Department of Neurology, Royal North Shore Hospital and Kolling Institute, University of Sydney (M.K.), and the Department of Neurology, St. Vincent's Hospital Sydney (R.M.), Sydney, and the Department of Neurology, Gosford Hospital, Gosford (J.S.), NSW, the Department of Neurology, Royal Adelaide Hospital (T.J.K., J.J.), the Department of Neurology, Lyell McEwin Hospital (D.F.), and the Department of Neurology, Queen Elizabeth Hospital (J.J.), Adelaide, SA, the Department of Medicine, Sunshine Coast University Hospital, Nambour (R.G.), the Department of Neurology, Royal Brisbane and Women's Hospital and the University of Queensland, Brisbane (A.A.W.), and the Department of Neurology, Gold Coast University Hospital, Southport (A.S.), and Australia and Griffith University, Gold Coast (A.S.), QLD - all in Australia; the Graduate Institute of Clinical Medical Science (C.H.) and the School of Medicine (C.-H.T.), China Medical University, and the Department of Neurology, China Medical University Hospital (C.-H.T.), Taichung, the Department of Neurology, Tri-Service General Hospital, National Defense Medical Center (J.-T.L.), the Department of Neurology, Shuang Ho Hospital (C.-J.H.), the Department of Neurology, En Chu Kong Hospital (Y.S.), the Stroke Center and Department of Neurology, National Taiwan University Hospital (J.-S.J.), and the Department of Neurology, Shin Kong Wu Ho-Su Memorial Hospital, Taipei Medical University College of Medicine (L.-M.L.), Taipei, the Stroke Center and Department of Neurology, Changhua Christian Hospital, Changhua (M.-C.S.), the Department of Neurology, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan (C.-H.C.), and the Department of Neurology, Kaohsiung Veterans General Hospital, Kaohsiung (C.-H.L.) - all in Taiwan; the Department of Neurology, Helsinki University Hospital, Helsinki (S. Curtze, A.M.); the Department of Neurology, Auckland City Hospital, University of Auckland, Auckland, New Zealand (P.A.B.); and the Stanford Stroke Center, Stanford University, Stanford, CA (S. Christensen).

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http://www.nejm.org/doi/10.1056/NEJMoa1813046
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http://dx.doi.org/10.1056/NEJMoa1813046DOI Listing
May 2019

Thresholds for infarction vary between gray matter and white matter in acute ischemic stroke: A CT perfusion study.

J Cereb Blood Flow Metab 2019 Mar 27;39(3):536-546. Epub 2017 Nov 27.

1 Priority Research Centre for Stroke and Brain Injury, University of Newcastle and Hunter Medical Research Institute, Newcastle, Australia.

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http://dx.doi.org/10.1177/0271678X17744453DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6421247PMC
March 2019

Predicting Modafinil-Treatment Response in Poststroke Fatigue Using Brain Morphometry and Functional Connectivity.

Stroke 2019 03;50(3):602-609

Department of Neurology, John Hunter Hospital (T.P.L., C.G.-E., N.J.S., M.W.P., C.R.L., A.B.), University of Newcastle, Australia.

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http://dx.doi.org/10.1161/STROKEAHA.118.023813DOI Listing
March 2019

Tenecteplase for the treatment of acute ischemic stroke: A review of completed and ongoing randomized controlled trials.

Int J Stroke 2018 12 23;13(9):885-892. Epub 2018 Jul 23.

3 Departments of Medicine and Neurology, Melbourne Brain Centre at the Royal Melbourne Hospital, University of Melbourne, Parkville, VIC, Australia.

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http://journals.sagepub.com/doi/full/10.1177/174749301879002
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http://dx.doi.org/10.1177/1747493018790024DOI Listing
December 2018

Identification of Corticospinal Tract Lesion for Predicting Outcome in Small Perfusion Stroke.

Stroke 2018 11;49(11):2683-2691

From the Department of Neurology (Y.Z., R.Z., S.Y., Meixia Zhang, Z.C., H.H., M.L.), the Second Affiliated Hospital of Zhejiang University, School of Medicine, Hangzhou, China.

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https://www.ahajournals.org/doi/10.1161/STROKEAHA.118.021426
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http://dx.doi.org/10.1161/STROKEAHA.118.021426DOI Listing
November 2018

Imaging selection for acute stroke intervention.

Int J Stroke 2018 08 15;13(6):554-567. Epub 2018 Mar 15.

1 Department of Medicine and Neurology, Melbourne Brain Centre at the Royal Melbourne Hospital, University of Melbourne, Parkville, Australia.

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http://dx.doi.org/10.1177/1747493018765235DOI Listing
August 2018

Correction for Delay and Dispersion Results in More Accurate Cerebral Blood Flow Ischemic Core Measurement in Acute Stroke.

Stroke 2018 04 2;49(4):924-930. Epub 2018 Mar 2.

From the School of Medicine and Public Health, University of Newcastle, Australia (L.L., A.B., N.J.S., C.R.L., M.W.P.); Department of Neurology, Royal Adelaide Hospital, Australia (T.K.); Department of Neurology, John Hunter Hospital, Newcastle, Australia (N.J.S., C.R.L., M.W.P.); and Apollo Medical Imaging Technology Pty Ltd, Melbourne, VIC, Australia (Q.Y.).

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https://www.ahajournals.org/doi/10.1161/STROKEAHA.117.019562
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http://dx.doi.org/10.1161/STROKEAHA.117.019562DOI Listing
April 2018

Tenecteplase versus Alteplase before Thrombectomy for Ischemic Stroke.

N Engl J Med 2018 04;378(17):1573-1582

From the Departments of Medicine and Neurology, Melbourne Brain Centre (B.C.V.C., N.Y., B.Y., T.Y.W., D.G.S., E.R., H.Z., P.S., G.S., M.W.P., S.M.D.), and the Department of Radiology (P.J.M., R.J.D., S.J.B., P.M.D.), Royal Melbourne Hospital, and the Florey Institute of Neuroscience and Mental Health (L.C., N.Y., V.T., H.A., H.M., C.F.B., G.A.D.), University of Melbourne, Parkville, VIC, the Departments of Neurology (T.J.K.) and Radiology (R.S.), Royal Adelaide Hospital, and the Department of Neurology, Lyell McEwin Hospital (D.F.), Adelaide, SA, the Department of Neurosciences, Eastern Health and Eastern Health Clinical School (H.M.D., C.F.B.), and the Departments of Neurology (H.M., T.G.P.) and Radiology (W. Chong, R.V.C., L.-A.S.), Monash Medical Centre, Monash University, Clayton, VIC, the Departments of Neurology (V.T., M.S.) and Radiology (M.B., H.A.), Austin Hospital, Austin Health, Heidelberg, VIC, School of Medicine, Faculty of Health, Deakin University, Melbourne, VIC (H.A.), and the Departments of Medicine and Neurology, Melbourne Medical School, University of Melbourne and Western Health, Sunshine Hospital, St. Albans, VIC (T.W.), the Departments of Neurology (D.G.S., H.B.) and Radiology (K.R., D.L.), Princess Alexandra Hospital, and the Departments of Neurology (A.A.W., C.M.) and Radiology (A.C., K. Mitchell, J.C., K. Mahady), Royal Brisbane and Women's Hospital and the University of Queensland, Brisbane, the Departments of Neurology (P.B.) and Radiology (H.R., L.V.), Gold Coast University Hospital, Southport, QLD, and the Department of Neurology, Priority Research Centre for Brain and Mental Health Research, John Hunter Hospital, University of Newcastle, Newcastle, NSW (T.A., F.M., C.R.L., C.G.-E., M.W.P.), the Department of Neurology, Royal North Shore Hospital and Kolling Institute, University of Sydney (M.K.), and the Department of Radiology, Royal North Shore Hospital (T.J.H., K.C.F., B.S.S.), St. Leonards, and the Department of Radiology, Westmead Hospital, Sydney (T.J.H., K.C.F., B.S.S.) - all in Australia; and the Departments of Neurology (T.Y.W., J.N.F.) and Radiology (W. Collecutt), Christchurch Hospital, Christchurch, New Zealand.

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http://dx.doi.org/10.1056/NEJMoa1716405DOI Listing
April 2018

Influence of Penumbral Reperfusion on Clinical Outcome Depends on Baseline Ischemic Core Volume.

Stroke 2017 10 8;48(10):2739-2745. Epub 2017 Sep 8.

From the Department of Neurology, John Hunter Hospital, University of Newcastle, Australia (C.C., M.P., C.L., L.L., A.B.); Public Health Stream, Hunter Medical Research Institute, Newcastle, Australia (M.C., C.O.); Department of Neurology, Huashan Hospital, Fudan University, Shanghai, China (X.C., Q.D.); Department of Neurology, Second Affiliated Hospital of Zhejiang University, Hangzhou, China (M.L.); Department of Neurology, Royal Adelaide Hospital, Australia (T.K.); and Division of Neurology, Department of Medicine, University of Alberta, Edmonton, Canada (K.B.).

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http://dx.doi.org/10.1161/STROKEAHA.117.018587DOI Listing
October 2017

Visibility of CT Early Ischemic Change Is Significantly Associated with Time from Stroke Onset to Baseline Scan beyond the First 3 Hours of Stroke Onset.

J Stroke 2017 Sep 29;19(3):340-346. Epub 2017 Sep 29.

Department of Neurology, John Hunter Hospital, University of Newcastle, Newcastle, New South Wales, Australia.

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http://dx.doi.org/10.5853/jos.2016.01424DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5647641PMC
September 2017

Tenecteplase in ischemic stroke offers improved recanalization: Analysis of 2 trials.

Neurology 2017 Jul 2;89(1):62-67. Epub 2017 Jun 2.

From the Department of Neurology (A.B., C.R.L., N.S., M.W.P.), John Hunter Hospital, University of Newcastle, Australia; Institute of Neuroscience and Psychology, Queen Elizabeth University Hospital (X.H., B.K.C., D.K., F.C.M., I.F., K.W.M.), and Robertson Centre for Biostatistics (I.F.), University of Glasgow, UK; Department of Medicine and Neurology, Royal Melbourne Hospital (B.C.V.C., S.M.D.), and The Florey Institute of Neuroscience & Mental Health (C.F.B., G.A.D.), University of Melbourne, Parkville; and the Department of Neurology (C.F.B.), Eastern Health Clinical School, Monash University, Clayton, Australia.

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http://www.neurology.org/lookup/doi/10.1212/WNL.000000000000
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http://dx.doi.org/10.1212/WNL.0000000000004062DOI Listing
July 2017

Low- Versus Standard-Dose Alteplase in Patients on Prior Antiplatelet Therapy: The ENCHANTED Trial (Enhanced Control of Hypertension and Thrombolysis Stroke Study).

Stroke 2017 07 15;48(7):1877-1883. Epub 2017 Jun 15.

From the Department of Cardiovascular Sciences, National Institute for Health Research Biomedical Research Unit, University of Leicester, (T.G.R.); George Institute for Global Health, Neurological and Mental Health Division (X.W., H.A., L.B., R.I.L., M.W., J.C., C.S.A.), Faculty of Medicine, University of New South Wales (X.W., H.A., L.B., M.W., J.C., C.S.A.), and Department of Geriatric Medicine, Westmead Clinical School (R.I.L.), University of Sydney, Australia; Stroke Trials Unit, Division of Clinical Neuroscience, University of Nottingham, United Kingdom (P.M.B.); Department of Neurology and Rehabilitation Medicine, University of Cincinnati Neuroscience Institute (J.P.B.); Departments of Clinical Neurosciences and Radiology, Hotchkiss Brain Institute, University of Calgary, Canada (A.M.D.); Florey Institute of Neuroscience and Mental Health, University of Melbourne, Victoria, Australia (G.A.D.); Department of Neurology, Asan Medical Center, University of Ulsan, Seoul, Korea (J.S.K.); Department of Neurology and Psychiatry, Clinica Alemana de Santiago, Facultad de Medicina, Clinica Alemana Universidad del Desarrollo, Chile (P.M.L., V.V.O.); Departamento de Ciencias Neurológicas, Facultad de Medicina, Universidad de Chile, Santiago (P.M.L.); Department of Neurology, Stroke Center, Linkou Chang Gung Memorial Hospital and College of Medicine, Chang Gung University, Taoyuan, Taiwan (T.-H.L.); Stroke Division of Neurology Service, Hospital de Clinicas de Porto Alegre, University of Rio Grande do Sul, Brazil (S.C.O.M.); Department of Neurology, Christian Medical College, Ludhiana, Punjab, India (J.D.P.); Department of Neurology, John Hunter Hospital, University of Newcastle, Australia (M.W.P.); Department of Neurosciences and Behavioral Sciences, Ribeirao Preto Medical School, University of Sao Paulo, Brazil (O.M.P.-N.); Uo Neurologia, USL Umbria 1, Sedi di Citta di Castello e Branca, Italy (S.R.); Department of Cerebrovascular Medicine, National Cerebral and Cardiovascular Center, Suita, Osaka, Japan (S.S.); Yong Loo Lin School of Medicine, National University of Singapore (V.K.S.); Division of Neurology, National University Hospital, Singapore (V.K.S.); Department of Cerebrovascular Disease, 115 People's Hospital, Ho Chi Minh City, Vietnam (T.H.N.); The Shanghai Institute for Hypertension, Rui Jin Hospital, Shanghai Jiaotong University School of Medicine, China (J.-G.W.); Department of Epidemiology, Johns Hopkins University, Baltimore, MD (M.W.); George Institute for Global Health, University of Oxford, United Kingdom (M.W.); Department of Neurology, Royal Prince Alfred Hospital, Sydney, New South Wales, Australia (C.S.A.); and The George Institute China, Peking University Health Sciences Center, Beijing (C.S.A.).

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http://dx.doi.org/10.1161/STROKEAHA.116.016274DOI Listing
July 2017

Quantifying reperfusion of the ischemic region on whole-brain computed tomography perfusion.

J Cereb Blood Flow Metab 2017 Jun 1;37(6):2125-2136. Epub 2016 Jan 1.

1 School of Medicine and Public health, University of Newcastle, Newcastle, Australia.

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http://dx.doi.org/10.1177/0271678X16661338DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5464706PMC
June 2017

Determining the benefits of transcranial direct current stimulation on functional upper limb movement in chronic stroke.

Int J Rehabil Res 2017 Jun;40(2):138-145

aFaculty of Health and Medicine bPriority Research Centre for Stroke and Brain Injury cFunctional Neuroimaging Laboratory, School of Psychology dSchool of Medicine and Public Health, University of Newcastle, Callaghan eHunter Medical Research Institute, Newcastle fBrain and Mind Institute, University of Sydney, Sydney, New South Wales, Australia.

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http://dx.doi.org/10.1097/MRR.0000000000000220DOI Listing
June 2017

Age-related decline in task switching is linked to both global and tract-specific changes in white matter microstructure.

Hum Brain Mapp 2017 03 23;38(3):1588-1603. Epub 2016 Nov 23.

Functional Neuroimaging Laboratory, School of Psychology, University of Newcastle, Newcastle, Australia.

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http://dx.doi.org/10.1002/hbm.23473DOI Listing
March 2017

Perfusion computed tomography in patients with stroke thrombolysis.

Brain 2017 03;140(3):684-691

Departments of Neurology, John Hunter Hospital, University of Newcastle, Lookout Road, New Lambton Heights, NSW 2305, Australia.

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http://dx.doi.org/10.1093/brain/aww338DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5382947PMC
March 2017

The Basilar Artery on Computed Tomography Angiography Prognostic Score for Basilar Artery Occlusion.

Stroke 2017 03 22;48(3):631-637. Epub 2017 Feb 22.

From the Department of Medicine and Neurology, Royal Melbourne Hospital, University of Melbourne, Parkville, Australia (F.A., D.G.S., B.Y., S.M.D., B.C.V.C.); Department of Neurology (F.A., M.D., F.S., C.C.) and Department of Diagnostic Imaging and Interventional Radiology (R.F.), University Hospital Tor Vergata, Rome, Italy; I.R.C.C.S., Santa Lucia Foundation, Rome, Italy (M.D., C.C.); Department of Neurology, John Hunter Hospital, University of Newcastle, Australia (A.B., M.W.P., C.R.L.); and Department of Radiology, Royal Melbourne Hospital, University of Melbourne, Parkville, Australia (G.S., P.J.M., R.J.D., S.B.).

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http://dx.doi.org/10.1161/STROKEAHA.116.015492DOI Listing
March 2017

Impact of Computed Tomography Perfusion Imaging on the Response to Tenecteplase in Ischemic Stroke: Analysis of 2 Randomized Controlled Trials.

Circulation 2017 Jan 13;135(5):440-448. Epub 2016 Dec 13.

From Department of Neurology, John Hunter Hospital, University of Newcastle, Australia (A.B., P.M., C.R.L., M.W.D.); Institute of Neuroscience and Psychology, University of Glasgow, Queen Elizabeth University Hospital, Scotland, UK (X.H., B.K.C., D.K., F.C.M., I.F., K.W.M.); Department of Medicine and Neurology, Royal Melbourne Hospital (B.C.V.C., S.M.D.), and The Florey Institute of Neuroscience and Mental Health (C.F.B., G.A.D.), University of Melbourne, Australia; and Department of Neurology, Eastern Health Clinical School, Monash University, Melbourne, Australia (C.F.B.).

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http://dx.doi.org/10.1161/CIRCULATIONAHA.116.022582DOI Listing
January 2017

Corrigendum: No Effect of Anodal Transcranial Direct Current Stimulation Over the Motor Cortex on Response-Related ERPs during a Conflict Task.

Front Hum Neurosci 2016 17;10:584. Epub 2016 Nov 17.

Functional Neuroimaging Laboratory, School of Psychology, Faculty of Science and IT, University of NewcastleNewcastle, NSW, Australia; Priority Research Centre for Stroke and Brain Injury, University of NewcastleNewcastle, NSW, Australia; Hunter Medical Research InstituteNewcastle, NSW, Australia.

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http://dx.doi.org/10.3389/fnhum.2016.00584DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5112245PMC
November 2016

No Effect of Anodal Transcranial Direct Current Stimulation Over the Motor Cortex on Response-Related ERPs during a Conflict Task.

Front Hum Neurosci 2016 5;10:384. Epub 2016 Aug 5.

Functional Neuroimaging Laboratory, School of Psychology, Faculty of Science and IT, University of NewcastleNewcastle, NSW, Australia; Priority Research Centre for Stroke and Brain Injury, University of NewcastleNewcastle, NSW, Australia; Hunter Medical Research InstituteNewcastle, NSW, Australia.

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http://dx.doi.org/10.3389/fnhum.2016.00384DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4974251PMC
August 2016

Whole-Brain CT Perfusion to Quantify Acute Ischemic Penumbra and Core.

Radiology 2016 Jun 18;279(3):876-87. Epub 2016 Jan 18.

From the School of Medicine and Public Health, University of Newcastle, Newcastle, Australia (L.L., A.B., V.K., C.R.L., M.W.P.); and Department of Neurology, John Hunter Hospital, University of Newcastle, Newcastle, Australia (V.K., C.R.L., M.W.P.).

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http://dx.doi.org/10.1148/radiol.2015150319DOI Listing
June 2016

Low-Dose versus Standard-Dose Intravenous Alteplase in Acute Ischemic Stroke.

N Engl J Med 2016 Jun 10;374(24):2313-23. Epub 2016 May 10.

From the George Institute for Global Health (C.S.A., R.I.L., H.A., X.C., L.B., M.W., Q.L., X.W., J.C.) and Sydney Medical School (C.S.A., R.I.L., H.A., X.C., L.B., M.W., Q.L., J.C.), University of Sydney, and the Neurology Department, Royal Prince Alfred Hospital, Sydney Health Partners (C.S.A.), Sydney, the Neurology Department, John Hunter Hospital, and Hunter Medical Research Institute, University of Newcastle, Newcastle, NSW (M.W.P., C.L.), and the Florey Institute of Neuroscience and Mental Health, Parkville, VIC (G.A.D.) - all in Australia; the George Institute China, Peking University (C.S.A.), and the Department of Neurology, Peking University First Hospital (Y.H.), Beijing, the Department of Neurology, Xuzhou Central Hospital, Xuzhou (G.C.), the Department of Neurology, the Second Affiliated Hospital of Soochow University, Suzhou (Y.C.), and the Shanghai Institute of Hypertension, Rui Jin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai (J.W.) - all in China; the University of Leicester, Department of Cardiovascular Sciences and National Institute of Health Research Biomedical Research Unit, Leicester (T.R.), the Stroke Trials Unit, Division of Clinical Neuroscience, University of Nottingham, Nottingham (P.M.B.), the Department of Neurosciences, Royal Stoke University Hospital, Stoke-on-Trent (C.R.), and the George Institute for Global Health, University of Oxford, Oxford (M.W.) - all in the United Kingdom; the Department of Preventive Medicine and Public Health, Faculty of Medicine, Fukuoka University, Fukuoka, Japan (H.A.); Clinica Alemana de Santiago, Facultad de Medicina, Clinica Alemana Universidad del Desarrollo (P.M.L., V.V.O.), and Departamento de Ciencias Neurológicas, Facultad de Medicina, Universidad de Chile (P.M.L.), Santiago, Chile; the Department of Neurology, Linkou Chang Gung Memorial Hospital, Taoyuan, Taiwan (T.-H.L.); the Departments of Neurology and Rehabilitation Medicine and Radiology, University of Cincinnati Neur

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http://dx.doi.org/10.1056/NEJMoa1515510DOI Listing
June 2016

The velocity of collateral filling predicts recanalization in acute ischemic stroke after intravenous thrombolysis.

Sci Rep 2016 06 14;6:27880. Epub 2016 Jun 14.

Department of Neurology, the Second Affiliated Hospital of Zhejiang University, School of Medicine, Hangzhou, China.

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http://dx.doi.org/10.1038/srep27880DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4906285PMC
June 2016

Acute Stroke Imaging Research Roadmap III Imaging Selection and Outcomes in Acute Stroke Reperfusion Clinical Trials: Consensus Recommendations and Further Research Priorities.

Stroke 2016 05 12;47(5):1389-98. Epub 2016 Apr 12.

From the Department of Neurology, Dell Medical School, University of Texas at Austin (S.J.W.); Stroke Branch, National Institute of Neurological Disorders and Stroke (NINDS), National Institutes of Health (NIH), Bethesda, MD (M.L.); Department of Neurology (G.W.A., M.G.L.), Department of Radiology (R.B.), Neuroradiology Section, Department of Radiology (J.J.H., M.P.M., M.W.), Stanford University School of Medicine, CA; Department of Neurology, John Hunter Hospital, Hunter Medical Research Institute, University of Newcastle, Callaghan, New South Wales, Australia (A.B., M.W.P.); Departments of Medicine and Neurology, Melbourne Brain Centre at the Royal Melbourne Hospital, University of Melbourne, Parkville, Victoria, Australia (B.C.V.C.); Department of Radiology, University of Iowa Hospitals and Clinics Iowa City (C.D.); Departments of Neurology (P.K.) and Neuroadiology (A.V.), University of Cincinnati, OH; Neurovascular Imaging Research Core and UCLA Stroke Center, Department of Neurology, University of California, Los Angeles (D.S.L.); Department of Radiology, AMC, Amsterdam, The Netherlands (C.B.L.M.M.); Calgary Stroke Program, Departments of Clinical Neurosciences and Radiology, Hotchkiss Brain Institute, University of Calgary, Calgary, Alberta, Canada (B.K.M.); Institute of Neurosciences and Psychology, University of Glasgow, Southern General Hospital, Glasgow, Scotland, United Kingdom (K.W.M.); Texas Stroke Institute, Plano (A.J.Y.); Department of Neurology, The University of Tennessee Health Science Center, Memphis (A.V.A.); INSERM U894, Centre Hospitalier Sainte-Anne, Sorbonne Paris Cité, Paris, France (J.-C.B.); Department of Clinical Neurosciences, University of Cambridge, Cambridge, United Kingdom (J.-C.B.); Department of Neurosurgery, State University of New York at Stony Brook (D.J.F.); Department of Neurology, University Hospitals Case Medical Center and Case Western Reserve University, Cleveland, OH (A.J.F.); Department of Radiology, Hospital Josep Tru

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May 2016

Pioglitazone after Ischemic Stroke or Transient Ischemic Attack.

N Engl J Med 2016 Apr 17;374(14):1321-31. Epub 2016 Feb 17.

From the School of Medicine (W.N.K., C.M.V., L.H.Y., S.E.I., A.M.L., L.M.B., J.R.O.) and the School of Public Health (P.D.G., P.N.P., J.R.O.), Yale University, New Haven, and the Cooperative Studies Program Coordinating Center, Veteran Affairs (VA) Connecticut HealthCare System, West Haven (P.D.G., P.N.P.) - all in Connecticut; Alpert Medical School, Brown University, Providence, RI (K.L.F.); Vermont College of Medicine, Burlington (M.G.); the National Institute of Neurological Disorders and Stroke, Bethesda, MD (R.C.); the VA Medical Center and the University of Colorado School of Medicine, Denver (G.G.S.); the University of Iowa, Iowa City (H.P.A.); Hôpital Charles LeMoyne, Greenfield Park, QC (L.B.), the University of Western Ontario, London (J.D.S.), and the Center for Neurological Research, Lethbridge, AB (T.R.W.) - all in Canada; University of L'Aquila, L'Aquila, Italy (A.C.); Oregon Health Sciences University, Portland (W.C.); the University of Arizona, Tucson (B.C.); the University of Oxford and Oxford University Hospitals NHS Foundation Trust, Oxfordshire, United Kingdom (G.A.F.); the University of Cincinnati, Cincinnati (D.K.); John Hunter Hospital, University of Newcastle, New Lambton Heights, NSW, Australia (M.W.P.); the University of Heidelberg, Heidelberg, Germany (P.R.); the University of South Carolina School of Medicine, Columbia (S.S.); Sheba Medical Center, Tel Aviv University, Tel Aviv, Israel (D.T.); and the Illinois Neurological Institute-OSF Saint Francis Medical Center and the Department of Neurology, University of Illinois College of Medicine at Peoria, Peoria (D.W.).

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4887756PMC
April 2016

Relationship Between Collateral Status, Contrast Transit, and Contrast Density in Acute Ischemic Stroke.

Stroke 2016 Mar 2;47(3):742-9. Epub 2016 Feb 2.

From the Department of Neurology, John Hunter Hospital, Hunter Medical Research Institute, and the University of Newcastle, Newcastle, New South Wales, Australia.

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March 2016

Contralesional thalamic surface atrophy and functional disconnection 3 months after ischemic stroke.

Cerebrovasc Dis 2015 25;39(3-4):232-41. Epub 2015 Mar 25.

Departments of Medicine and Neurology, Melbourne Brain Centre at The Royal Melbourne Hospital, Parkville, Vic., Australia.

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February 2016

Microstructural white matter changes mediate age-related cognitive decline on the Montreal Cognitive Assessment (MoCA).

Psychophysiology 2016 Feb 29;53(2):258-67. Epub 2015 Oct 29.

Functional Neuroimaging Laboratory, School of Psychology, Faculty of Science & IT, University of Newcastle, Newcastle, Australia.

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February 2016

Defining Core and Penumbra in Ischemic Stroke: A Voxel- and Volume-Based Analysis of Whole Brain CT Perfusion.

Sci Rep 2016 Feb 10;6:20932. Epub 2016 Feb 10.

Department of Neurology, Second Affiliated Hospital of Zhejiang University, Hangzhou, Zhejiang, China.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4748242PMC
February 2016

Anodal tDCS over the Motor Cortex on Prepared and Unprepared Responses in Young Adults.

PLoS One 2015 1;10(5):e0124509. Epub 2015 May 1.

Functional Neuroimaging Laboratory, School of Psychology, University of Newcastle, Newcastle, Australia; Priority Research Centre for Translational Neuroscience and Mental Health, University of Newcastle, Newcastle, Australia; Hunter Medical Research Institute, Newcastle, Australia.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4416898PMC
January 2016

Association between baseline peri-infarct magnetic resonance spectroscopy and regional white matter atrophy after stroke.

Neuroradiology 2016 Jan 16;58(1):3-10. Epub 2015 Sep 16.

Departments of Medicine and Neurology, Melbourne Brain Centre @ The Royal Melbourne Hospital, 4 Centre, The Royal Melbourne Hospital, Grattan St, Parkville, Victoria, 3050, Australia.

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January 2016

The association between lesion location and functional outcome after ischemic stroke.

Int J Stroke 2015 Dec 4;10(8):1270-6. Epub 2015 Jun 4.

Department of Neurology, Melbourne Brain Centre @ Royal Melbourne Hospital, University of Melbourne, Parkville, Vic., Australia.

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December 2015

A Randomized Controlled Trial of the Effect of Early Upper-Limb Training on Stroke Recovery and Brain Activation.

Neurorehabil Neural Repair 2015 Sep 19;29(8):703-13. Epub 2014 Dec 19.

University of Newcastle, NSW, Australia Hunter New England Local Health District, Newcastle, NSW, Australia.

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September 2015

Computed Tomography Perfusion in Acute Ischemic Stroke: Is It Ready for Prime Time?

Stroke 2015 Aug 9;46(8):2364-7. Epub 2015 Jul 9.

From the Neurovascular Imaging Research Core (D.S.L.) and Comprehensive Stroke Center and Department of Neurology, Division of Stroke, Geffen School of Medicine (D.S.L.), University of California, Los Angeles; Department of Neurology, John Hunter Hospital, University of Newcastle, Newcastle, Australia (M.W.P.); Department of Radiology, Neuroradiology Section, Stanford University, Palo Alto, CA (M.W.); Department of Neurology, Division of Stroke and Cerebrovascular Disease, Beth Israel Deaconess Medical Center, Boston, MA (M.S.); Stroke Unit, Department of Neurology, Hospital Vall d'Hebron, Barcelona, Spain (C.A.M.); and Department of Radiology, Neuroradiology Division, Massachusetts General Hospital, Boston, MA (M.H.L., R.G.G).

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August 2015

International survey of acute stroke imaging used to make revascularization treatment decisions.

Int J Stroke 2015 Jul 2;10(5):759-62. Epub 2015 Apr 2.

Seton/UT Southwestern Clinical Research Institute of Austin, Department of Neurology and Neurotherapeutics, UT Southwestern Medical Center, Austin, TX, USA.

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http://dx.doi.org/10.1111/ijs.12491DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5286907PMC
July 2015

Know your tools--concordance of different methods for measuring brain volume change after ischemic stroke.

Neuroradiology 2015 Jul 8;57(7):685-95. Epub 2015 Apr 8.

Departments of Medicine and Neurology, Melbourne Brain Centre @ The Royal Melbourne Hospital, The University of Melbourne, Grattan St, Parkville, Victoria, 3050, Australia,

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http://dx.doi.org/10.1007/s00234-015-1522-8DOI Listing
July 2015

Reorganizing therapy: changing the clinical approach to upper limb recovery post-stroke.

Occup Ther Int 2015 Mar 18;22(1):28-35. Epub 2014 Oct 18.

School of Medicine and Public Health, University of Newcastle, Callaghan, Australia.

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March 2015

Optimal magnetic resonance perfusion thresholds identifying ischemic penumbra and infarct core: a Chinese population-based study.

CNS Neurosci Ther 2015 Mar 5;21(3):289-95. Epub 2014 Dec 5.

Department of Neurology, the Second Affiliated Hospital of Zhejiang University, School of Medicine, Hangzhou, China.

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http://dx.doi.org/10.1111/cns.12367DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6495880PMC
March 2015

Repeat brain imaging after thrombolysis is important.

Int J Stroke 2015 Feb;10(2):E18

Department of Medicine and Neurology, Royal Melbourne Hospital, Parkville, Vic., Australia.

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February 2015

Imaging selection in ischemic stroke: feasibility of automated CT-perfusion analysis.

Int J Stroke 2015 Jan 16;10(1):51-4. Epub 2014 Oct 16.

Department of Medicine, Royal Melbourne Hospital, Melbourne, Australia; Department of Radiology, Royal Melbourne Hospital, Melbourne, Australia.

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http://dx.doi.org/10.1111/ijs.12381DOI Listing
January 2015

Spectroscopy of reperfused tissue after stroke reveals heightened metabolism in patients with good clinical outcomes.

J Cereb Blood Flow Metab 2014 Dec 1;34(12):1944-50. Epub 2014 Oct 1.

Department of Neurology, John Hunter Hospital, Hunter Medical Research Institute, University of Newcastle, Callaghan, NSW, Australia.

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December 2014

The spot sign and tranexamic acid on preventing ICH growth--AUStralasia Trial (STOP-AUST): protocol of a phase II randomized, placebo-controlled, double-blind, multicenter trial.

Int J Stroke 2014 Jun 26;9(4):519-24. Epub 2013 Aug 26.

Department of Medicine, University of Melbourne, Parkville, Victoria, Australia; Department of Neurology, The Royal Melbourne Hospital, Parkville, Victoria, Australia; The Florey Institute of Neuroscience and Mental Health, Parkville, Victoria, Australia; Department of Neurology, Helsinki University Central Hospital, Helsinki, Finland.

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June 2014

Comparison of computed tomographic and magnetic resonance perfusion measurements in acute ischemic stroke: back-to-back quantitative analysis.

Stroke 2014 Jun 13;45(6):1727-32. Epub 2014 May 13.

From the Stroke Research Program, Hunter Medical Research Institute (L.L., A.B., C.R.L., M.W.P.) and Department of Neurology, John Hunter Hospital (C.R.L., M.W.P.), The University of Newcastle, Newcastle, New South Wales, Australia.

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June 2014

Cerebrospinal fluid is drained primarily via the spinal canal and olfactory route in young and aged spontaneously hypertensive rats.

Fluids Barriers CNS 2014 6;11:12. Epub 2014 Jun 6.

University of Newcastle and Hunter Medical Research Institute, University of Newcastle: School of Biomedical Sciences & Pharmacy, Medical Sciences Building, Callaghan, NSW 2308, Australia.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4057524PMC
June 2014

Reperfusion after 4.5 hours reduces infarct growth and improves clinical outcomes.

Int J Stroke 2014 Apr 21;9(3):266-9. Epub 2013 Nov 21.

Department of Medicine and Neurology, Melbourne Brain Centre at the Royal Melbourne Hospital, University of Melbourne, Melbourne, Australia.

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http://dx.doi.org/10.1111/ijs.12209DOI Listing
April 2014

Stroke thrombolysis: save a minute, save a day.

Stroke 2014 Apr 13;45(4):1053-8. Epub 2014 Mar 13.

From the Florey Institute of Neuroscience and Mental Health, University of Melbourne, Melbourne, Australia (A.M., M.K., G.A.D., L.C.); Departments of Neurology and Medicine, Royal Melbourne Hospital, University of Melbourne, Melbourne, Australia (A.M., S.M.D.); Department of Neurology, Helsinki University Central Hospital, Helsinki, Finland (A.M., T.T., M.K.); UCLA Stroke Center, Los Angeles, CA (J.L.S.); John Hunter Hospital and the Hunter Medical Research Institute, University of Newcastle, Newcastle, Australia (M.W.P.); and School of Mathematical and Geospatial Sciences, RMIT University, Melbourne, Australia (M.K., L.C.).

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April 2014

Five Years of Acute Stroke Unit Care: Comparing ASU and Non-ASU Admissions and Allied Health Involvement.

Stroke Res Treat 2014 3;2014:798258. Epub 2014 Mar 3.

Neurology Department, John Hunter Hospital, Hunter New England Health, Locked Bag 1, Hunter Region Mail Centre, NSW 2301, Australia ; School of Medicine and Public Health, University of Newcastle, Hunter New England Local Health District, Callaghan NSW 2308, Australia.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3960564PMC
April 2014

Early detection of microstructural white matter changes associated with arterial pulsatility.

Front Hum Neurosci 2013 18;7:782. Epub 2013 Nov 18.

Functional Neuroimaging Laboratory, Faculty of Science and IT, School of Psychology, University of Newcastle Newcastle, NSW, Australia ; Centre for Translational Neuroscience and Mental Health Research, University of Newcastle Newcastle, NSW, Australia ; Hunter Medical Research Institute Newcastle, NSW, Australia.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3831342PMC
December 2013

Prediction of poststroke hemorrhagic transformation using computed tomography perfusion.

Stroke 2013 Nov 3;44(11):3039-43. Epub 2013 Sep 3.

From the Departments of Medicine and Neurology, Melbourne Brain Centre (N.Y., A.B., S.M.D., B.C.V.C.), and Department of Radiology (N.Y., S.C., G.S., P.M.D., B.C.V.C.), Royal Melbourne Hospital, and Florey Institute of Neuroscience and Mental Health (G.A.D.), University of Melbourne, Parkville, Victoria, Australia; and Priority Research Centre for Translational Neuroscience and Mental Health, University of Newcastle and Hunter Medical Research Institute, Newcastle, New South Wales, Australia (M.W.P., C.R.L.).

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November 2013

The ipsilesional upper limb can be affected following stroke.

ScientificWorldJournal 2013 Nov 26;2013:684860. Epub 2013 Nov 26.

Stroke Research, Neurology Department, John Hunter Hospital, Hunter New England Local Health District, Locked Bag 1, Hunter Regional Mail Centre, NSW 2310, Australia.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3860125PMC
November 2013

Brain CT perfusion provides additional useful information in severe traumatic brain injury.

Injury 2013 Sep 30;44(9):1208-12. Epub 2013 Apr 30.

Department of Traumatology, Newcastle, NSW, Australia.

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September 2013

Acute Stroke Imaging Research Roadmap II.

Stroke 2013 Sep 16;44(9):2628-39. Epub 2013 Jul 16.

Department of Radiology, University of Virginia, Charlottesville, VA, USA.

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http://dx.doi.org/10.1161/STROKEAHA.113.002015DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4040226PMC
September 2013

Perfusion patterns of ischemic stroke on computed tomography perfusion.

J Stroke 2013 Sep 27;15(3):164-73. Epub 2013 Sep 27.

Department of Neurology, John Hunter Hospital, Hunter Medical Research Institute, the University of Newcastle, Newcastle, Australia.

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http://dx.doi.org/10.5853/jos.2013.15.3.164DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3859000PMC
September 2013

Failure of collateral blood flow is associated with infarct growth in ischemic stroke.

J Cereb Blood Flow Metab 2013 Aug 8;33(8):1168-72. Epub 2013 May 8.

Departments of Medicine and Neurology, Melbourne Brain Centre at the Royal Melbourne Hospital, University of Melbourne, Parkville, Victoria, Australia.

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http://dx.doi.org/10.1038/jcbfm.2013.77DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3734777PMC
August 2013

MR RESCUE: is the glass half-full or half-empty?

Stroke 2013 Jul 11;44(7):2055-7. Epub 2013 Jun 11.

Department of Neurology, John Hunter Hospital, Hunter Medical Research Institute, University of Newcastle, New South Wales, Australia.

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July 2013

CT perfusion improves diagnostic accuracy and confidence in acute ischaemic stroke.

J Neurol Neurosurg Psychiatry 2013 Jun 25;84(6):613-8. Epub 2013 Jan 25.

Department of Medicine, Melbourne Brain Centre at Royal Melbourne Hospital, University of Melbourne, Parkville, Victoria, Australia.

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http://dx.doi.org/10.1136/jnnp-2012-303752DOI Listing
June 2013

Assessment of leptomeningeal collaterals using dynamic CT angiography in patients with acute ischemic stroke.

J Cereb Blood Flow Metab 2013 Mar 14;33(3):365-71. Epub 2012 Nov 14.

Calgary Stroke Program, Department of Clinical Neurosciences, Hotchkiss Brain Institute, University of Calgary, Calgary, Alberta, Canada.

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http://dx.doi.org/10.1038/jcbfm.2012.171DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3587807PMC
March 2013

Comparison of computed tomography perfusion and magnetic resonance imaging perfusion-diffusion mismatch in ischemic stroke.

Stroke 2012 Oct 2;43(10):2648-53. Epub 2012 Aug 2.

Department of Medicine, The Melbourne Brain Centre at Royal Melbourne Hospital, University of Melbourne, Parkville, Victoria, Australia.

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October 2012

Reperfusion trials for acute ischaemic stroke.

Lancet 2012 Aug 28;380(9843):706-8. Epub 2012 Jun 28.

Department of Neurology, John Hunter Hospital/Hunter Medical Research Institute, University of Newcastle, Newcastle, NSW 2305, Australia.

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August 2012

Hematoma growth and outcomes in intracerebral hemorrhage: the INTERACT1 study.

Neurology 2012 Jul 27;79(4):314-9. Epub 2012 Jun 27.

The George Institute for Global Health, Royal Prince Alfred Hospital, University of Sydney, Australia.

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July 2012

Moving beyond a single perfusion threshold to define penumbra: a novel probabilistic mismatch definition.

Stroke 2012 Jun 12;43(6):1548-55. Epub 2012 Apr 12.

National Stroke Research Institute, Florey Neuroscience Institutes, Austin Health, University of Melbourne, Victoria 3053, Australia.

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June 2012

Sudden limb weakness.

Med J Aust 2012 May;196(9):572-7

Department of Neurology, John Hunter Hospital, Newcastle, NSW.

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May 2012

Assessing response to stroke thrombolysis: validation of 24-hour multimodal magnetic resonance imaging.

Arch Neurol 2012 Jan 12;69(1):46-50. Epub 2011 Sep 12.

BMedSc, FRACP, Department of Neurology, Royal Melbourne Hospital, Grattan Street, Parkville, Victoria 3050, Australia.

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http://dx.doi.org/10.1001/archneurol.2011.232DOI Listing
January 2012

Cerebral blood flow is the optimal CT perfusion parameter for assessing infarct core.

Stroke 2011 Dec 6;42(12):3435-40. Epub 2011 Oct 6.

Department of Medicine, The Royal Melbourne Hospital, University of Melbourne, Grattan Street, Parkville VIC 3050, Australia.

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December 2011