Mark W Kieran

Mark W Kieran

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Mark W Kieran

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Outcome of Children Treated for Infantile Hepatic Hemangioendothelioma.

J Pediatr Hematol Oncol 2020 Mar;42(2):126-130

Departments of Pediatric Hematology and Oncology.

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http://dx.doi.org/10.1097/MPH.0000000000001536DOI Listing
March 2020

Sixty years single institutional experience with pediatric craniopharyngioma: between the past and the future.

Childs Nerv Syst 2020 Feb 10;36(2):291-296. Epub 2019 Jul 10.

Department of Neurosurgery, Boston Children's Hospital, 300 Longwood Ave, Boston, MA, 02115, USA.

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http://dx.doi.org/10.1007/s00381-019-04294-xDOI Listing
February 2020

Cutaneous reactions to targeted therapies in children with CNS tumors: A cross-sectional study.

Pediatr Blood Cancer 2019 06 28;66(6):e27682. Epub 2019 Feb 28.

Dermatology Program, Boston Children's Hospital, Boston, Massachusetts.

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http://dx.doi.org/10.1002/pbc.27682DOI Listing
June 2019

Hedgehog signaling inhibitors in solid and hematological cancers.

Cancer Treat Rev 2019 Jun 6;76:41-50. Epub 2019 May 6.

Ameriderm Research, 725 W Granada Blvd Ste 44, Ormond Beach, FL 32174, USA; University of Central Florida, Orlando, FL, USA. Electronic address:

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http://dx.doi.org/10.1016/j.ctrv.2019.04.005DOI Listing
June 2019

Epigenetics in Clinical Management of Children and Adolescents with Brain Tumors.

Curr Cancer Drug Targets 2018 ;18(1):57-64

The Pediatric Brain Tumor Center, Department of Pediatric Oncology, Dana-Farber/Boston Children's Cancer and Blood Disorders Center, Boston, MA, United States.

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http://www.eurekaselect.com/149769/article
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http://dx.doi.org/10.2174/1568009617666170203164456DOI Listing
May 2019

Aspirin-triggered proresolving mediators stimulate resolution in cancer.

Proc Natl Acad Sci U S A 2019 03 12;116(13):6292-6297. Epub 2019 Mar 12.

Center for Vascular Biology Research, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215;

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http://dx.doi.org/10.1073/pnas.1804000116DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6442621PMC
March 2019

Chemotherapy-generated cell debris stimulates colon carcinoma tumor growth via osteopontin.

FASEB J 2019 01 29;33(1):114-125. Epub 2018 Jun 29.

Center for Vascular Biology Research, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, USA.

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http://dx.doi.org/10.1096/fj.201800019RRDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6355061PMC
January 2019

Desmoplastic nodular medulloblastoma in young children: a management dilemma.

Neuro Oncol 2018 07;20(8):1026-1033

Dana-Farber Boston Children's Cancer and Blood Disorders Center, Harvard Medical School, Boston, Massachusetts.

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http://dx.doi.org/10.1093/neuonc/nox222DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6280315PMC
July 2018

Clinical, Radiologic, Pathologic, and Molecular Characteristics of Long-Term Survivors of Diffuse Intrinsic Pontine Glioma (DIPG): A Collaborative Report From the International and European Society for Pediatric Oncology DIPG Registries.

J Clin Oncol 2018 07 10;36(19):1963-1972. Epub 2018 May 10.

Lindsey M. Hoffman and Nicholas K. Foreman, University of Colorado Denver; Lindsey M. Hoffman and Nicholas K. Foreman, Children's Hospital Colorado, Aurora, CO; Sophie E.M. Veldhuijzen van Zanten, Esther Hulleman, Gertjan J.L. Kaspers, Esther Sanchez, and Dannis G. van Vuurden, Vrije Universiteit University Medical Center, Amsterdam; William P. Vandertop, Academy of Princess Máxima Center for Pediatric Oncology, Utrecht, the Netherlands; Niclas Colditz, Marion Hoffmann, Brigitte Bison, Monika Warmuth-Metz, and Christof M. Kramm, University Medical Center Goettingen, Goettingen; Torsten Pietsch and Gerrit H. Gielen, University of Bonn Medical Center, Bonn; David T.W. Jones, Dominik Sturm, Stefan M. Pfister, and Elke Pfaff, German Cancer Research Center, Hopp-Children's Cancer Center at the Nationale Centrum für Tumorerkrankungen Heidelberg, and German Consortium for Translational Cancer Research; Dominik Sturm, Stefan M. Pfister, and Elke Pfaff, Heidelberg University Hospital, Heidelberg, Germany; Joshua Baugh, Brooklyn Chaney, Adam Lane, Christine Fuller, Nancy Yanez Escorza, Renee Doughman, Rachid Drissi, James Leach, Blaise Jones, and Maryam Fouladi, Cincinnati Children's Hospital Medical Center, Cincinnati; Emmett Broxson, Wright State University and The Children's Medical Center, Dayton, OH; Lili Miles, Nemours Children's Hospital, Orlando, FL; Cynthia Hawkins, Ute Bartels, and Eric Bouffet, The Hospital for Sick Children, Toronto, Ontario; Anne Sophie Carret, Centre Hospitalier Universitaire Sainte-Justine; Nada Jabado, McGill University, Montreal, Quebec, Canada; Stewart Goldman, Ann and Robert H Lurie Children's Hospital of Chicago, Chicago, IL; Sarah Leary, Seattle Children's Hospital, University of Washington and Fred Hutchinson Cancer Research Center, Seattle, WA; Roger Packer, Children's National Health System; Javad Nazarian, Children's National Medical Center, Washington, DC; Katherine E. Warren, National Cancer Institute, Bethesda, MD; Alberto Broniscer, St Jude Children's Research Hospital, Memphis, TN; Mark W. Kieran, Dana-Farber Boston Children's Cancer and Blood Disorders Center, Boston, MA; Jane Minturn, Children's Hospital of Philadelphia and The Perelman School of Medicine at the University of Pennsylvania, Philadelphia; Melanie Comito, The Pennsylvania State University, Hershey, PA; Chie-Schin Shih, Indiana University, Indianapolis, IN; Soumen Khatua, The University of Texas MD Anderson Cancer Center; Murali Chintagumpala, Texas Children's Cancer and Hematology Centers, Baylor College of Medicine, Houston, TX; Timothy Hassall, Lady Cilento Children's Hospital, Brisbane, Queensland; David S. Ziegler, Kids Cancer Centre, Sydney Children's Hospital, Randwick; David S. Ziegler, University of New South Wales, Sydney, New South Wales; Nicholas Gottardo and Hetal Dholaria, Princess Margaret Hospital for Children, Perth, Western Australia, Australia; Martin Benesch, Medical University of Graz, Graz, Austria; Nathalie Boddaert. Stephanie Puget, and Raphaël Calmon, Hôpital Necker Enfants Malades; Pascale Varlet, Hôpital Sainte-Anne, Université Paris V Descartes, Sorbonne Paris Cité, Paris; Géraldine Giraud, David Castel, and Jacques Grill, Gustave Roussy, Université Paris-Sud, Université Paris-Saclay, Villejuif, France; Géraldine Giraud, Uppsala University, Uppsala, Sweden; Chris Jones, The Institute of Cancer Research, Sutton; Darren Hargrave, Great Ormond Street Hospital, London; Guirish A. Solanki, Birmingham Women's and Children's Hospital, Birmingham; Simon Bailey, Great North Children's Hospital, Victoria Wing, Royal Victoria Infirmary, Newcastle upon Tyne, United Kingdom; Piergiorgio Modena and Marzia Giagnacovo, Sant' Anna Como General Hospital, Como; Manila Antonelli, Sapienza University of Rome, Rome; Veronica Biassoni and Maura Massimino, Fondazione Istituto Di Ricovero e Cura a Carattere Scientifico, Istituto Nazionale dei Tumori, Milan, Italy; Nicolas U. Gerber and Michael A. Grotzer, University Children's Hospital of Zurich, Zurich; André O. von Bueren, University Hospital of Geneva and University of Geneva, Geneva, Switzerland; and Filip Jadrijevic Cvrlje and Gertjan J.L. Kaspers, Children's Hospital Zagreb, Zagreb, Croatia.

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http://dx.doi.org/10.1200/JCO.2017.75.9308DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6075859PMC
July 2018

Pubertal Progression in Female Adolescents with Progeria.

J Pediatr Adolesc Gynecol 2018 Jun 16;31(3):238-241. Epub 2017 Dec 16.

Department of Pediatrics, Cincinnati Children's Hospital Medical Center and University of Cincinnati College of Medicine, Cincinnati, Ohio. Electronic address:

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http://dx.doi.org/10.1016/j.jpag.2017.12.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6671321PMC
June 2018

Survey of plasma proteins in children with progeria pre-therapy and on-therapy with lonafarnib.

Pediatr Res 2018 05 28;83(5):982-992. Epub 2018 Feb 28.

The Vascular Biology Program and The Department of Surgery, Boston Children's Hospital and Harvard Medical School, Boston, Massachusetts.

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http://dx.doi.org/10.1038/pr.2018.9DOI Listing
May 2018

Response to the BRAF/MEK inhibitors dabrafenib/trametinib in an adolescent with a BRAF V600E mutated anaplastic ganglioglioma intolerant to vemurafenib.

Pediatr Blood Cancer 2018 05 30;65(5):e26969. Epub 2018 Jan 30.

Department of Pediatric Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts.

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http://doi.wiley.com/10.1002/pbc.26969
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http://dx.doi.org/10.1002/pbc.26969DOI Listing
May 2018

The Integration of Biology Into the Treatment of Diffuse Intrinsic Pontine Glioma: A Review of the North American Clinical Trial Perspective.

Front Oncol 2018 18;8:169. Epub 2018 May 18.

Department of Pediatric Oncology, Dana-Farber Cancer Institute, Boston, MA, United States.

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http://dx.doi.org/10.3389/fonc.2018.00169DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5968382PMC
May 2018

New Classification for Central Nervous System Tumors: Implications for Diagnosis and Therapy.

Am Soc Clin Oncol Educ Book 2017 ;37:753-763

From the Cincinnati Children's Hospital Medical Center, Cincinnati, OH; German Cancer Research Center, Heidelberg, Germany; Dana-Farber Cancer Institute, Boston, MA.

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http://dx.doi.org/10.1200/EDBK_175088DOI Listing
November 2017

A novel GIT2-BRAF fusion in pilocytic astrocytoma.

Diagn Pathol 2017 Nov 15;12(1):82. Epub 2017 Nov 15.

Department of Pathology, Boston Children's Hospital, 300 Longwood Ave, Bader, Boston, MA, 02115, USA.

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http://dx.doi.org/10.1186/s13000-017-0669-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5688665PMC
November 2017

Phase I study of oral sonidegib (LDE225) in pediatric brain and solid tumors and a phase II study in children and adults with relapsed medulloblastoma.

Neuro Oncol 2017 Oct;19(11):1542-1552

Pediatric Neuro-Oncology, Dana-Farber Boston Children's Cancer Blood Disorders Center, Harvard Medical School, Boston, Massachusetts, USA; The Royal Marsden Hospital, Sutton, Surrey, UK; Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy; Department of Medical Oncology, Azienda USL-IRCCS Institute of Neurological Science, Bologna, Italy; Institut Curie and University Paris Descartes, Paris, France; Division of Haematology/Oncology at The Hospital for Sick Children, Toronto, Ontario, Canada; Sir James Spence Institute of Child Health Royal Victoria Infirmary, Newcastle, UK; Seattle Children's Hospital, University of Washington and Fred Hutchinson Cancer Research Center, Seattle, Washington, USA; Aflac Cancer and Blood Disorders Center, Children's Healthcare of Atlanta, Emory University School of Medicine, Atlanta, Georgia, USA; The Royal Children's Hospital, Children's Cancer Center, Melbourne, Australia; The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore, Maryland, USA; Catholic University of the Sacred Heart, Rome, Italy; Cancer Clinical Research Unit, Princess Margaret Cancer Centre, Toronto, Ontario, Canada; Paediatric Oncology Unit, Great Ormond Street Hospital, London, UK; Novartis Pharmaceuticals Corporation, East Hanover, New Jersey, USA; Gustave Roussy, Department of Pediatric and Adolescent Oncology, University Paris-Sud, Université Paris-Saclay, Villejuif, France.

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http://dx.doi.org/10.1093/neuonc/nox109DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5737275PMC
October 2017

Rethinking childhood ependymoma: a retrospective, multi-center analysis reveals poor long-term overall survival.

J Neurooncol 2017 Oct 21;135(1):201-211. Epub 2017 Jul 21.

Pediatric Neuro-Oncology Program, Dana-Farber/Boston Children's Cancer and Blood Disorders Center, Dana-Farber Cancer Institute and Boston Children's Hospital and Harvard Medical School, 450 Brookline Avenue, Boston, MA, 02215, USA.

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http://dx.doi.org/10.1007/s11060-017-2568-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5658456PMC
October 2017

Ophthalmologic Features of Progeria.

Am J Ophthalmol 2017 Oct 27;182:126-132. Epub 2017 Jul 27.

Department of Anesthesia, Boston Children's Hospital - Harvard Medical School, Boston, Massachusetts; Department of Pediatrics, Hasbro Children's Hospital - Warren Alpert Medical School of Brown University, Providence, Rhode Island.

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http://dx.doi.org/10.1016/j.ajo.2017.07.020DOI Listing
October 2017

Paucicellular Fibrointimal Proliferation Characterizes Pediatric Pulmonary Vein Stenosis: Clinicopathologic Analysis of 213 Samples From 97 Patients.

Am J Surg Pathol 2017 Sep;41(9):1198-1204

Departments of *Pathology †Cardiology ∥Cardiac Surgery, Boston Children's Hospital §Department of Pediatric Oncology, Dana Farber Cancer Institute, Boston, MA ‡Department of Pathology, Mayo Clinic, Rochester, MN.

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http://dx.doi.org/10.1097/PAS.0000000000000892DOI Listing
September 2017

Concomitant Use of Panobinostat and Reirradiation in Progressive DIPG: Report of 2 Cases.

J Pediatr Hematol Oncol 2017 08;39(6):e332-e335

Departments of *Pediatrics, Division of Pediatric Hematology Oncology †Oncology, Molecular Therapeutics Program ‡Radiology §Pathology ∥Neurosurgery, Children's Hospital of Michigan #Radiation Oncology, Karmanos Cancer Institute, Wayne State University School of Medicine, Detroit, MI ¶Dana-Farber Boston Children's Cancer and Blood Disorders Center, Boston, MA.

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http://dx.doi.org/10.1097/MPH.0000000000000806DOI Listing
August 2017

Lessons learned from diffuse intrinsic pontine glioma: how a terrible disease forced us to think better.

Authors:
Mark W Kieran

Neuro Oncol 2017 08;19(8):1017-1018

Pediatric Medical Neuro-Oncology, Dana-Farber Boston Children's Cancer and Blood Disorders Center, Harvard Medical School, Boston, Massachusetts.

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http://dx.doi.org/10.1093/neuonc/nox022DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5570137PMC
August 2017

Clinical targeted exome-based sequencing in combination with genome-wide copy number profiling: precision medicine analysis of 203 pediatric brain tumors.

Neuro Oncol 2017 Jul;19(7):986-996

Dana-Farber/Boston Children's Cancer and Blood Disorders Center, Department of Pathology, Department of Radiology, Department of Neurosurgery, Boston Children's Hospital, Boston, Massachusetts; Department of Medical Oncology, Oncologic Pathology, Department of Pediatric Oncology, Department of Cancer Biology, Center for Cancer Genome Discovery, Dana-Farber Cancer Institute, Boston, Massachusetts; Department of Pathology, Department of Neurosurgery, Department of Medicine, Brigham and Women's Hospital, Boston, Massachusetts; Pratiti Bandopadhayay, Broad Institute of MIT and Harvard, Boston, Massachusetts; Harvard Medical School, Boston, Massachusetts.

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http://dx.doi.org/10.1093/neuonc/now294DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5570190PMC
July 2017

Distinct patterns of primary and motile cilia in Rathke's cleft cysts and craniopharyngioma subtypes.

Mod Pathol 2016 12 26;29(12):1446-1459. Epub 2016 Aug 26.

Department of Pathology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.

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http://dx.doi.org/10.1038/modpathol.2016.153DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5442446PMC
December 2016

Gliomatosis cerebri: A consensus summary report from the First International Gliomatosis cerebri Group Meeting, March 26-27, 2015, Paris, France.

Pediatr Blood Cancer 2016 12 28;63(12):2072-2077. Epub 2016 Jul 28.

Department of Pediatric Hematology and Oncology, Hospital Sant Joan de Deu, Barcelona, Spain.

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http://dx.doi.org/10.1002/pbc.26169DOI Listing
December 2016

Biopsy for diffuse intrinsic pontine glioma: a reappraisal.

J Neurosurg Pediatr 2016 Sep 6;18(3):390-1. Epub 2016 May 6.

University of California, San Francisco, CA.

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http://dx.doi.org/10.3171/2015.6.PEDS15374DOI Listing
September 2016

Long-term visual outcomes of optic pathway gliomas in pediatric patients without neurofibromatosis type 1.

J Neurooncol 2016 08 16;129(1):173-8. Epub 2016 Jun 16.

Department of Ophthalmology, Boston Children's Hospital, Harvard Medical School, 300 Longwood Avenue, Fegan 4, Boston, MA, 02115, USA.

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http://dx.doi.org/10.1007/s11060-016-2163-4DOI Listing
August 2016

Central Versus Extraventricular Neurocytoma in Children: A Clinicopathologic Comparison and Review of the Literature.

J Pediatr Hematol Oncol 2016 08;38(6):479-85

*Children and Young People's Unit, The Royal Marsden NHS Foundation Trust, Sutton, Surrey, UK†Pediatric Neuro-Oncology, Dana-Farber Cancer InstituteDepartments of ‡Pediatric Hematology/Oncology§Neurology∥Radiation Oncology¶Neurosurgery#Radiology, Boston Children's Hospital**Department of Pathology, Brigham and Women's Hospital, Boston, MA.

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http://dx.doi.org/10.1097/MPH.0000000000000627DOI Listing
August 2016

Clinical Trial of the Protein Farnesylation Inhibitors Lonafarnib, Pravastatin, and Zoledronic Acid in Children With Hutchinson-Gilford Progeria Syndrome.

Circulation 2016 Jul;134(2):114-25

From Departments of Anesthesia (L.B.G., M.E.K., A.A.D., K.L., M.M.G.), Cardiology (L.B.S.), Radiology (R.H.C., V.M.S.), Orthopedics (B.D.S.), Neurology (N.J.U.), Dermatology (M.G.L.), Genetics and Genomics (D.T.M.), Gastroenterology and Nutrition (S.Y.H.), and Hematology Oncology (M.W.K.), and Clinical Translational Study Unit (N.Q.), Boston Children's Hospital and Harvard Medical School, MA; Department of Pediatrics, Hasbro Children's Hospital and Warren Alpert Medical School of Brown University, Providence, RI (L.B.G.); Department of Biostatistics, Boston University School of Public Health and Harvard Clinical Research Institute, MA (J.M., R.B.D., H.S.); Division of Cardiology, Brigham and Women's Hospital and Harvard Medical School, Boston, MA (M.G.-H.); Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati Children's Hospital Medical Center, OH (C.M.G.); Center for Advanced Orthopaedic Studies, Department of Orthopedic Surgery, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA (A.N.); and Division of Pediatric Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA (M.W.K.).

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http://dx.doi.org/10.1161/CIRCULATIONAHA.116.022188DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4943677PMC
July 2016

Multidisciplinary pediatric brain tumor clinics: the key to successful treatment?

CNS Oncol 2015 ;4(3):147-55

Cardinal Glennon Children's Medical Center, St Louis University School of Medicine, 1465 S. Grand Boulevard, St Louis, MO 63104-1095, USA.

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http://dx.doi.org/10.2217/cns.15.1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6088326PMC
February 2016

Targeting BRAF in pediatric brain tumors.

Authors:
Mark W Kieran

Am Soc Clin Oncol Educ Book 2014 :e436-40

From the Dana-Farber Cancer Institute and Boston Children's Hospital, Boston, MA.

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http://dx.doi.org/10.14694/EdBook_AM.2014.34.e436DOI Listing
December 2015

Expression profiles of 151 pediatric low-grade gliomas reveal molecular differences associated with location and histological subtype.

Neuro Oncol 2015 Nov 29;17(11):1486-96. Epub 2015 Mar 29.

Department of Cancer Biology, Dana-Farber Cancer Institute, and Harvard Medical School, Boston, Massachusetts (G.B., P.B., B.R.P., S.E.S., B.T., R.F.-L., C.S., R.S., R.B.); Broad Institute, Cambridge, Massachusetts (G.B., P.B., B.R.P., S.E.S., B.T., R.F.-L., T.G., R.B.); Pediatric Neuro-Oncology Program, Dana-Farber/Boston Children's Cancer and Blood Disorders Center, Dana-Farber Cancer Institute and Boston Children's Hospital, and Harvard Medical School, Boston, Massachusetts (P.B., L.C.G., M.W.K.); Liver Cancer Program, Tisch Cancer Institute, Division of Liver Diseases, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, New York (Y.H.); Department of Pathology, Brigham and Women's Hospital, Boston, Massachusetts (S.R., S.S., P.Y.W., A.H.L., K.L.L., J.A.C.); Center for Molecular Oncologic Pathology, Dana-Farber Cancer Institute, Boston, Massachusetts (S.R., L.R., B.R., C.L.M., K.L.L.); Department of Neurosurgery, Acibadem University Medical Center, Istanbul, Turkey (M.O.); Department of Pathology, Acibadem University Medical Center, Istanbul, Turkey (A.S.); Department of Neurosurgery, Boston Children's Hospital, Boston, Massachusetts (L.C.G.); Departement de Cancerologie de l'enfant et de l'adolescent, Gustave Roussy and Unité Mixte de Recherche 8203 du Centre National de la Recherche Scientifique, Université Paris-Sud, Villejuif, France (J.G.); Department of Pathology, Boston Children's Hospital, Boston, Massachusetts (K.L.L.).

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http://dx.doi.org/10.1093/neuonc/nov045DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4648300PMC
November 2015

Future Clinical Trials in DIPG: Bringing Epigenetics to the Clinic.

Front Oncol 2015 1;5:148. Epub 2015 Jul 1.

Pediatric Neuro-Oncology, Department of Pediatric Hematology/Oncology, Dana-Farber Cancer Institute, Boston Children's Hospital , Boston, MA , USA.

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http://dx.doi.org/10.3389/fonc.2015.00148DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4486770PMC
July 2015

Pediatric brainstem gliomas: new understanding leads to potential new treatments for two very different tumors.

Curr Oncol Rep 2015 Mar;17(3):436

Pediatric Neuro-Oncology, Center for Cancer and Blood Disorders, Department of Pediatrics, University of Colorado School of Medicine and Children's Hospital Colorado, University of Colorado School of Medicine, University of Colorado Anschutz Medical Campus, Mail Stop 8302 12800 E. 19th Ave., RC1-N, Aurora, CO, 80045, USA,

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http://dx.doi.org/10.1007/s11912-014-0436-7DOI Listing
March 2015

Initial cutaneous manifestations of Hutchinson-Gilford progeria syndrome.

Pediatr Dermatol 2014 Mar-Apr;31(2):196-202. Epub 2014 Jan 24.

Department of Dermatology, Boston Children's Hospital, Harvard Medical School, Boston, Massachusetts.

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http://dx.doi.org/10.1111/pde.12284DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4130100PMC
January 2015

Time to rethink the unthinkable: upfront biopsy of children with newly diagnosed diffuse intrinsic pontine glioma (DIPG).

Authors:
Mark W Kieran

Pediatr Blood Cancer 2015 Jan 4;62(1):3-4. Epub 2014 Oct 4.

Dana-Farber Cancer Institute and Boston Children's Hospital, Pediatric Neuro-Oncology, Harvard Medical School, Boston, Massachusetts.

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http://dx.doi.org/10.1002/pbc.25266DOI Listing
January 2015

Recurrent ascites in a patient with low-grade astrocytoma and ventriculo-peritoneal shunt treated with the multikinase inhibitor sorafenib.

J Pediatr Hematol Oncol 2014 Nov;36(8):e533-5

Departments of *Pediatrics ∥Radiology, NYU Langone Medical Center, New York, NY Departments of †Pediatric Oncology §Neurosurgery, Boston Children's Hospital ‡Department of Pediatric Neuro-Oncology, Dana-Farber Cancer Institute, Boston, MA.

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http://content.wkhealth.com/linkback/openurl?sid=WKPTLP:land
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http://dx.doi.org/10.1097/MPH.0000000000000094DOI Listing
November 2014

Diffuse intrinsic pontine glioma: a reassessment.

J Neurooncol 2014 Aug 3;119(1):7-15. Epub 2014 May 3.

Pediatric Neuro-Oncology Program, Children's Hospital Los Angeles, University of Southern California Keck School of Medicine, 4650 W Sunset Blvd, MS#54, Los Angeles, CA, 90027, USA,

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http://link.springer.com/10.1007/s11060-014-1448-8
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http://dx.doi.org/10.1007/s11060-014-1448-8DOI Listing
August 2014

Targeted treatment for sonic hedgehog-dependent medulloblastoma.

Authors:
Mark W Kieran

Neuro Oncol 2014 Aug 20;16(8):1037-47. Epub 2014 Jun 20.

Pediatric Medical Neuro-Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts.

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http://dx.doi.org/10.1093/neuonc/nou109DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4096181PMC
August 2014

Long-term outcome of 4,040 children diagnosed with pediatric low-grade gliomas: an analysis of the Surveillance Epidemiology and End Results (SEER) database.

Pediatr Blood Cancer 2014 Jul 30;61(7):1173-9. Epub 2014 Jan 30.

Division of Pediatric Hematology/Oncology, Department of Pediatric Oncology, Dana-Farber Cancer Institute, Boston Children's Hospital, Boston, Massachusetts; Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, Massachusetts.

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http://dx.doi.org/10.1002/pbc.24958DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4657506PMC
July 2014

Impact of farnesylation inhibitors on survival in Hutchinson-Gilford progeria syndrome.

Circulation 2014 Jul 2;130(1):27-34. Epub 2014 May 2.

From the Department of Pediatrics, Hasbro Children's Hospital and Warren Alpert Medical School of Brown University, Providence, RI (L.B.G.); Department of Anesthesia, Division of Critical Care Medicine, Boston Children's Hospital and Harvard Medical School, Boston, MA (L.B.G., M.E.K.); Department of Mathematics and Statistics, Boston University, Harvard Clinical Research Institute, Boston, MA (J.M., R.B.D.); Center for Gerontology and Health Care Research, Brown University, Providence, RI (S.E.C., J.B.); Department of Genetics, New York State Institute for Basic Research, Staten Island, NY (W.T.B.); Hematology-Oncology, Boston Children's Hospital, Division of Pediatric Oncology, Dana-Farber Cancer Institute and Harvard Medical School, Boston, MA (M.W.K.).

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http://dx.doi.org/10.1161/CIRCULATIONAHA.113.008285DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4082404PMC
July 2014

Phase 2 randomized, flexible crossover, double-blinded, placebo-controlled trial of the farnesyltransferase inhibitor tipifarnib in children and young adults with neurofibromatosis type 1 and progressive plexiform neurofibromas.

Neuro Oncol 2014 May 4;16(5):707-18. Epub 2014 Feb 4.

Pediatric Oncology Branch, National Cancer Institute, Bethesda, Maryland (B.W., E.D., A.G., P.W., S.M., E.F., F.B.); Cancer Therapy Evaluation Program, Investigational Drug Branch, National Cancer Institute, Bethesda, Maryland (J.W.); Biostatistics and Data Management Section, National Cancer Institute, Bethesda, Maryland (S.S.); Diagnostic Radiology Department, National Institutes of Health, Bethesda, Maryland (N.P.); The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania (J.B., E.F., F.B.); Ann and Robert H. Lurie Children's Hospital, Chicago, Illinois (S.G.); Department of Genetics, University of Alabama at Birmingham, South Birmingham, Alabama (B.K.); Expert Image Analysis LC, Potomac, Maryland (J.S.); Dana-Farber/Children's Hospital Cancer Center, Boston, Massachusetts (M.K.); Cincinnati Children's Hospital, Cincinnati, Ohio (J.P.); Children's National Medical Center, Washington, DC (A.K.); US Army Medical Research and Material Command, Fort Detrick, Maryland (W.S.); Children's Hospital of Alabama, Birmingham, Alabama (A.R.).

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http://dx.doi.org/10.1093/neuonc/nou004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3984559PMC
May 2014

Pediatric low-grade gliomas: how modern biology reshapes the clinical field.

Biochim Biophys Acta 2014 Apr 28;1845(2):294-307. Epub 2014 Feb 28.

Center for Molecular Oncologic Pathology, Dana-Farber Cancer Institute, Boston, MA, USA; Center for Molecular Oncologic Pathology, Dana-Farber Cancer Institute, Boston, MA, USA. Electronic address:

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http://dx.doi.org/10.1016/j.bbcan.2014.02.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4082403PMC
April 2014

Genome sequencing of SHH medulloblastoma predicts genotype-related response to smoothened inhibition.

Cancer Cell 2014 Mar;25(3):393-405

Division of Pediatric Neurooncology, German Cancer Research Center (DKFZ), 69121 Heidelberg, Germany; Department of Pediatric Oncology, Hematology and Immunology, University Hospital Heidelberg, 69120 Heidelberg, Germany.

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http://dx.doi.org/10.1016/j.ccr.2014.02.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4493053PMC
March 2014

BET bromodomain inhibition of MYC-amplified medulloblastoma.

Clin Cancer Res 2014 Feb 2;20(4):912-25. Epub 2013 Dec 2.

Authors' Affiliations: Departments of Cancer Biology and Medical Oncology, Dana-Farber Cancer Institute and Harvard Medical School; Pediatric Neuro-Oncology, Department of Pediatric Oncology, Dana-Farber Cancer Institute and Division of Pediatric Hematology/Oncology, Boston Children's Hospital; Center for Cancer Genome Characterization, Dana-Farber Cancer Institute, Boston; The Broad Institute of MIT and Harvard, Cambridge, Massachusetts; Departments of Neurology and Neurological Sciences and Neurosurgery, Stanford University School of Medicine; Stanford Cancer Institute, Stanford University Medical Center, Stanford; Tumor Initiation and Maintenance Program, NCI-Designated Cancer Center, Sanford-Burnham Medical Research Institute, La Jolla; Department of Neurology, Pediatrics, and Neurosurgery, University of California, San Francisco, California; and Department of Immunology, Genetics and Pathology, Science for Life Laboratory, Rudbeck Laboratory, Uppsala University, Uppsala, Sweden.

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http://dx.doi.org/10.1158/1078-0432.CCR-13-2281DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4198154PMC
February 2014

Exome sequencing identifies BRAF mutations in papillary craniopharyngiomas.

Nat Genet 2014 Feb 12;46(2):161-5. Epub 2014 Jan 12.

1] Harvard Medical School, Boston, Massachusetts, USA. [2] Department of Pathology, Boston Children's Hospital, Boston, Massachusetts, USA. [3] Department of Pathology, Brigham and Women's Hospital, Boston, Massachusetts, USA. [4] Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, Massachusetts, USA. [5].

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http://dx.doi.org/10.1038/ng.2868DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3982316PMC
February 2014

The growing role of eicosanoids in tissue regeneration, repair, and wound healing.

Prostaglandins Other Lipid Mediat 2013 Jul-Aug;104-105:130-8. Epub 2013 May 28.

Vascular Biology Program, Boston Children's Hospital, Harvard Medical School, Boston, MA, USA.

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http://dx.doi.org/10.1016/j.prostaglandins.2013.05.002DOI Listing
January 2014

Predictors of neoplastic disease in children with isolated pituitary stalk thickening.

Pediatr Blood Cancer 2013 Oct 14;60(10):1630-5. Epub 2013 May 14.

Department of Pediatric Oncology, Dana-Farber Cancer Institute, Boston Children's Hospital, Boston, MA, USA.

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http://dx.doi.org/10.1002/pbc.24577DOI Listing
October 2013

Role of collagen matrix in tumor angiogenesis and glioblastoma multiforme progression.

Am J Pathol 2013 Oct 5;183(4):1293-1305. Epub 2013 Aug 5.

Vascular Biology Program, Department of Surgery, Boston Children's Hospital and Harvard Medical School, Boston, Massachusetts. Electronic address:

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http://dx.doi.org/10.1016/j.ajpath.2013.06.026DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3791684PMC
October 2013

Phase II study of cilengitide in the treatment of refractory or relapsed high-grade gliomas in children: a report from the Children's Oncology Group.

Neuro Oncol 2013 Oct 5;15(10):1438-44. Epub 2013 Sep 5.

Corresponding Author: Tobey J. MacDonald, MD, Emory Children's Center, Aflac Cancer and Blood Disorders Center, 2015 Uppergate Drive NE, Suite 442, Atlanta, GA 30322.

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http://dx.doi.org/10.1093/neuonc/not058DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3779033PMC
October 2013

New strategies in pediatric gliomas: molecular advances in pediatric low-grade gliomas as a model.

Clin Cancer Res 2013 Sep 23;19(17):4553-8. Epub 2013 Jul 23.

The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore, Maryland 21287, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4696061PMC
September 2013

Specific uptake of 99mTc-NC100692, an αvβ3-targeted imaging probe, in subcutaneous and orthotopic tumors.

Nucl Med Biol 2013 Aug 20;40(6):788-94. Epub 2013 May 20.

Division of Nuclear Medicine and Molecular Imaging, Department of Radiology, Boston Children's Hospital, Boston, MA 02115, USA.

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http://dx.doi.org/10.1016/j.nucmedbio.2013.04.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4267260PMC
August 2013

Recurrent somatic alterations of FGFR1 and NTRK2 in pilocytic astrocytoma.

Nat Genet 2013 Aug 30;45(8):927-32. Epub 2013 Jun 30.

Division of Pediatric Neurooncology, German Cancer Research Center (DKFZ), Heidelberg, Germany.

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August 2013

Neurologic features of Hutchinson-Gilford progeria syndrome after lonafarnib treatment.

Neurology 2013 Jul 28;81(5):427-30. Epub 2013 Jun 28.

Department of Neurology, Boston Children's Hospital and Harvard Medical School, Boston, MA, USA.

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http://dx.doi.org/10.1212/WNL.0b013e31829d85c0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3776537PMC
July 2013