Publications by authors named "Mark W Hall"

92Publications

Health-Related Quality of Life After Community-Acquired Septic Shock in Children With Preexisting Severe Developmental Disabilities.

Pediatr Crit Care Med 2020 Nov 6. Epub 2020 Nov 6.

1 Department of Pediatrics, Children's Hospital of Michigan, Central Michigan University, Detroit, MI. 2 Department of Pediatrics, University of Utah, Salt Lake City, UT. 3 Department of Pediatrics, Children's Hospital of Colorado, University of Colorado School of Medicine, Aurora, CO. 4 Department of Anesthesiology and Critical Care Medicine, Children's Hospital of Philadelphia, Philadelphia, PA. 5 Department of Anesthesiology Critical Care Medicine, Children's Hospital Los Angeles, Los Angeles, CA. 6 Department of Pediatrics, Nationwide Children's Hospital, Columbus, OH. 7 Department of Pediatrics, C.S. Mott Children's Hospital, University of Michigan, Ann Arbor, MI. 8 Department of Critical Care Medicine, Children's Hospital of Pittsburgh, University of Pittsburgh Medical Center, Pittsburgh, PA. 9 Department of Pediatrics, Benioff Children's Hospital, University of California, San Francisco, San Francisco, CA. 10 Department of Pediatrics, Cincinnati Children's Hospital Medical Center, Cincinnati, OH. 11 Center for Child Health, Behavior and Development, Seattle Children's Hospital, Seattle Research Institute, Seattle, WA. 12 Department of Pediatrics, Seattle Children's Hospital, Seattle Research Institute, University of Washington School of Medicine, Seattle, WA.

View Article and Find Full Text PDF
November 2020

Measures of Systemic Innate Immune Function Predict the Risk of Nosocomial Infection in Pediatric Burn Patients.

J Burn Care Res 2020 Oct 31. Epub 2020 Oct 31.

Center for Clinical and Translation Research, The Research Institute at Nationwide Children's Hospital, Columbus, OH.

View Article and Find Full Text PDF
October 2020

A Core Outcome Set for Pediatric Critical Care.

Crit Care Med 2020 Dec;48(12):1819-1828

1Department of Critical Care Medicine, UPMC Children's Hospital of Pittsburgh, Pittsburgh, PA. 2Department of Pediatrics, Critical Care Medicine, University of Colorado School of Medicine, Children's Hospital Colorado, Aurora, CO. 3Department of Anesthesiology and Critical Care Medicine, Children's Hospital of Philadelphia, Philadelphia, PA. 4Department of Pediatrics, University of Utah School of Medicine, Salt Lake City, UT. 5Department of Molecular Biology, Princeton University, Princeton, NJ. 6Department of Pediatrics, Children's National Hospital, Washington, DC. 7Department of Pediatrics, Children's Hospital of Michigan, Detroit, MI. 8Department of Pediatrics, Nationwide Children's Hospital, Columbus, OH. 9Department of Pediatrics, Mattel Children's Hospital, University of California Los Angeles, Los Angeles, CA. 10Department of Pediatrics, Benioff Children's Hospital, University of California, San Francisco, San Francisco, CA. 11Collaborative Pediatric Critical Care Research Network Family Collaborative, Great Falls, VA. 12Department of Paediatrics and Child Health, University of Cape Town, and Red Cross War Memorial Children's Hospital, Cape Town, South Africa. 13Department of Pediatrics, University of São Paulo, São Paulo, Brazil. 14Intensive Care Department of Paediatrics, The Royal Childrens Hospital, Melbourne, VIC, Australia. 15Departments of Pediatrics and Critical Care, McMaster University, Hamilton, ON, Canada. 16Department of Family and Community Health (Nursing), Anesthesiology and Critical Care (Perelman School of Medicine), University of Pennsylvania; Research Institute, Children's Hospital of Philadelphia, Philadelphia, PA. 17Department of Pediatric Critical Care, Hospital de Niños Dr R. Gutierrez, Buenos Aires, Argentina. 18Department of Pediatric Intensive Care, Istanbul University, Child Health Institute and Istanbul Faculty of Medicine, Istanbul, Turkey. 19Department of Physical Medicine & Rehabilitation, University of Pittsburgh, Pittsburgh, PA. 20Department of Paediatrics, Centrum Universiteit van Amsterdam, Amsterdam, The Netherlands. 21Department of Pediatric Subspecialities, KK Women's and Children's Hospital, Singapore. 22School of Nursing, Centre for Healthcare Transformation, Queensland University of Technology, Brisbane, QLD, Australia. 23Children and Young People Health Research, School of Health Sciences, University of Nottingham and Nottingham Children's Hospital, Nottingham University Hospitals NHS Trust, Nottingham, United Kingdom. 24Department of Paediatrics and Child Health, University of Cape Town, Cape Town, South Africa. 25Department of Pediatrics, All India Institute of Medical Sciences, Chandigarh, India. 26Department of Neuropsychology, Kennedy Krieger Institute and Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, MD. 27Department of Pediatrics, University of Washington School of Medicine and Center for Child Health, Behavior, and Development, Seattle Children's Research Institute, Seattle, WA.

View Article and Find Full Text PDF
December 2020

Development of Persistent Respiratory Morbidity in Previously Healthy Children After Acute Respiratory Failure.

Crit Care Med 2020 Aug;48(8):1120-1128

1Department of Anesthesia and Critical Care Medicine, Children's Hospital of Philadelphia and University of Pennsylvania, Philadelphia, PA. 2Department of Pediatrics, Penn State University College of Medicine, Hershey, PA. 3Division of Critical Care Medicine, Nationwide Children's Hospital, The Ohio State University College of Medicine, Columbus, OH. 4Section of Critical Care Medicine, Department of Pediatrics, Texas Children's Hospital, Houston, TX. 5Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH. 6Division of Cardiology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH. 7Division of Pediatric Critical Care Medicine, Medical College of Wisconsin, Milwaukee, WI. 8Department of Pediatrics, Division of Critical Care, St. Jude Children's Research Hospital, Memphis, TN. 9Department of Pediatrics, Rush University Children's Hospital, Chicago, IL. 10Division of Emergency Medicine, Children's National Health System, Washington, DC. 11Department of Pediatrics, George Washington University School of Medicine and Health Sciences, Washington, DC. 12Department of Integrative Systems Biology, Children's National Medical Center, Washington, DC. 13Department of Pediatrics, Pediatric Critical Care, Children's Hospital of Richmond at VCU, Richmond, VA. 14Department of Pediatrics, George Washington University School of Medicine and Health Sciences, Washington, DC. 15University of Maryland Baltimore Washington Medical Center, Glen Burnie, MD.

View Article and Find Full Text PDF
August 2020

Immune modulation in COVID-19: Strategic considerations for personalized therapeutic intervention.

Clin Infect Dis 2020 Jul 1. Epub 2020 Jul 1.

Duke-National University of Singapore Medical School, Singapore.

View Article and Find Full Text PDF
July 2020

Respiratory pathogens associated with intubated pediatric patients following hematopoietic cell transplant.

Transpl Infect Dis 2020 Aug 28;22(4):e13297. Epub 2020 Apr 28.

Division of Critical Care, Department of Pediatrics, Riley Hospital for Children, Indiana University School of Medicine, Indianapolis, Indiana, USA.

View Article and Find Full Text PDF
August 2020

Development of a core outcome set for pediatric critical care outcomes research.

Contemp Clin Trials 2020 04 5;91:105968. Epub 2020 Mar 5.

Division of Pediatric Critical Care Medicine, Department of Pediatrics, University of Washington School of Medicine and Center for Child Health, Behavior, and Development, Seattle Children's Research Institute, 4800 Sand Point Way NE, Seattle, WA 98105, United States of America. Electronic address:

View Article and Find Full Text PDF
April 2020

Nosocomial Infection Following Severe Traumatic Injury in Children.

Pediatr Crit Care Med 2020 05;21(5):443-450

Center for Clinical and Translation Research, The Research Institute at Nationwide Children's Hospital, Columbus, OH.

View Article and Find Full Text PDF
May 2020

RIG-I and TLR4 responses and adverse outcomes in pediatric influenza-related critical illness.

J Allergy Clin Immunol 2020 Jun 6;145(6):1673-1680.e11. Epub 2020 Feb 6.

Boston Children's Hospital, Department of Anesthesiology, Critical Care and Pain Medicine, Boston, Mass; Department of Anesthesia, Harvard Medical School, Boston. Electronic address:

View Article and Find Full Text PDF
June 2020

Innate immune suppression after traumatic brain injury and hemorrhage in a juvenile rat model of polytrauma.

J Neuroimmunol 2019 12 15;337:577073. Epub 2019 Oct 15.

Center for Clinical and Translation Research, The Research Institute at Nationwide Children's Hospital, Columbus, OH, USA; Department of Pediatrics, Division of Critical Care, Nationwide Children's Hospital, Columbus, OH, USA. Electronic address:

View Article and Find Full Text PDF
December 2019

Evaluation of Mannose Binding Lectin Gene Variants in Pediatric Influenza Virus-Related Critical Illness.

Front Immunol 2019 8;10:1005. Epub 2019 May 8.

Division of Critical Care Medicine, Department of Anesthesiology, Critical Care and Pain Medicine, Boston Children's Hospital and Department of Anaesthesia, Harvard Medical School, Boston, MA, United States.

View Article and Find Full Text PDF
September 2020

Risk Factors for Mortality in Pediatric Postsurgical versus Medical Severe Sepsis.

J Surg Res 2019 10 7;242:100-110. Epub 2019 May 7.

Division of Critical Care Medicine, Department of Pediatrics, Nationwide Children's Hospital, The Ohio State University, Columbus, Ohio.

View Article and Find Full Text PDF
October 2019

Immune Modulation in Pediatric Sepsis.

Authors:
Mark W Hall

J Pediatr Intensive Care 2019 Mar 2;8(1):42-50. Epub 2019 Jan 2.

Division of Critical Care Medicine, Nationwide Children's Hospital, Columbus, Ohio, United States.

View Article and Find Full Text PDF
March 2019

Immune Modulation in Pediatric Sepsis.

Authors:
Mark W Hall

J Pediatr Intensive Care 2019 Mar 2;8(1):42-50. Epub 2019 Jan 2.

Division of Critical Care Medicine, Nationwide Children's Hospital, Columbus, Ohio, United States.

View Article and Find Full Text PDF
March 2019

The systemic immune response to pediatric thermal injury.

Int J Burns Trauma 2018 5;8(1):6-16. Epub 2018 Feb 5.

Center for Clinical and Translation Research, The Research Institute at Nationwide Children's Hospital700 Children's Drive, Columbus 43205, OH.

View Article and Find Full Text PDF
February 2018

Immunomodulatory effects of plasma products on monocyte function in vitro.

J Trauma Acute Care Surg 2018 06;84(6S Suppl 1):S47-S53

From the Department of Pediatrics (S.S., M.W.H., J.A.M.), Nationwide Children's Hospital; The Research Institute at Nationwide Children's Hospital (K.C., S.M., S.B., J.N., M.W.H., J.A.M.), Columbus, OH; Division Pediatric Critical Care, Department of Pediatrics (P.C.S.), Washington University in St Louis, St Louis, Missouri; Department of Pathology (K.N.), Nationwide Children's Hospital, Columbus, Ohio.

View Article and Find Full Text PDF
June 2018

The Functional Immune Response of Patients on Extracorporeal Life Support.

ASAIO J 2019 01;65(1):77-83

From the Division of Pediatric Critical Care Medicine, Department of Pediatrics, University of Michigan, C.S. Mott Children's Hospital, Ann Arbor, Michigan.

View Article and Find Full Text PDF
January 2019

Immunoparalysis in Pediatric Critical Care.

Pediatr Clin North Am 2017 10 18;64(5):1089-1102. Epub 2017 Aug 18.

Department of Pediatrics, Division of Critical Care Medicine, Nationwide Children's Hospital, 700 Children's Drive, Columbus, OH 43205, USA.

View Article and Find Full Text PDF
October 2017

Acanthamoeba granulomatous amoebic encephalitis after pediatric hematopoietic stem cell transplant.

Pediatr Transplant 2017 Dec 17;21(8). Epub 2017 Sep 17.

Department of Pediatrics, Division of Hematology/Oncology/BMT, Nationwide Children's Hospital and The Ohio State University, Columbus, OH, USA.

View Article and Find Full Text PDF
December 2017

The American College of Critical Care Medicine Clinical Practice Parameters for Hemodynamic Support of Pediatric and Neonatal Septic Shock: Executive Summary.

Pediatr Crit Care Med 2017 09;18(9):884-890

1No institution affiliation. 2Department of Critical Care Medicine and Pediatrics, University of Pittsburgh School of Medicine, Pittsburgh, PA. 3Department of Critical Care Medicine and Pediatrics, University of Pittsburgh School of Medicine, Pittsburgh, PA. 4Department of Pediatric Critical Care, Riley Hospital for Children, Indiana University, Bloomington, IN. 5Department of Pediatrics, Washington University School of Medicine, St. Louis, MO. 6Department of Pediatrics, Baylor College of Medicine/Texas Children's Hospital, Houston, TX. 7Department of Pediatrics, Baylor College of Medicine/Texas Children's Hospital, Houston, TX. 8Pediatric Critical Care Medicine, Covenant Women and Children's Hospital, Texas Tech University, Lubbock, TX. 9Department of Pediatrics, Division of Pediatric Critical Care Medicine, Feinberg School of Medicine, Northwestern University, Chicago, IL. 10Division of Pediatric Critical Care, University of British Columbia, Vancouver, BC, Canada. 11Department of Pediatrics, Division of Pediatric Critical Care Medicine, Medical College of Wisconsin, Milwaukee, WI. 12Department of Pediatrics, Baylor College of Medicine, Houston, TX. 13Department of Pediatrics, Saint Barnabas Medical Center, Livingston, NJ. 14Division of Emergency Medicine and Center for Pediatric Clinical Effectiveness, Children's Hospital of Philadelphia, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA. 15Intensive Care & Bioethics, Great Ormond St Hospital for Sick Children, London, United Kingdom. 16Pediatric Critical Care Medicine, Department of Pediatrics, Stollery Children's Hospital/University of Alberta, Edmonton, AB, Canada. 17Department of Pediatrics, Division of Pediatric Critical Care Medicine, Duke Children's, Durham, NC. 18Departments of Pediatrics and Critical Care, Clinical Epidemiology and Biostatistics, McMaster University, Pediatric Intensive Care Unit, McMaster Children's Hospital, Hamilton, ON, Canada. 19Beth Israel Medical Center, Hartsdale, NY. 20Department of Pediatrics and Communicable Diseases, University of Michigan, Ann Arbor, MI. 21Departments of Pediatrics and Biochemistry, Washington University in Saint Louis School of Medicine, St. Louis, MO. 22Department of Pediatrics, Centre mère-enfant Soleil du CHU de Québec-Université Laval, Québec City, QC, Canada. 23Department of Inpatient Pediatrics, Kaiser Santa Clara Medical Center, Santa Clara, CA. 24Department of Anesthesiology and Critical Care Medicine, University of Pennsylvania Perelman School of Medicine and The Children's Hospital of Philadelphia, Philadelphia, PA. 25Division of Pediatric Critical Care Medicine, Department of Pediatrics, University of Mott C.S. Children's Hospital, Ann Arbor, MI. 26Division of Critical Care, Department of Pediatrics, Emory University School of Medicine, Atlanta, GA. 27Department of Pediatrics-Critical Care Medicine, University of Maryland School of Medicine, Baltimore, MD. 28Division of Pediatric Critical Care Medicine, Weill Cornell Medical College, New York, NY. 29Department of Pediatrics, Division of Critical Care Medicine, Nationwide Children's Hospital, Columbus, OH. 30Department of Critical Care Medicine, Children's Mercy Hospital, Kansas City, MO. 31Department of Pediatrics, Texas Tech University Health Sciences Center, El Paso, TX. 32Division of Pediatric Critical Care, University of Florida, Jacksonville, FL 33Bon Secours St. Mary's Hospital, Glen Allen, VA. 34Department of Pediatrics/Division of Pediatric Critical Care, University of Rochester School of Medicine and Dentistry, Rochester, NY. 35Department of Pediatrics, University of Washington School of Medicine, Seattle, WA. 36Department of Pediatrics, Division of Critical Care, Stanford University School of Medicine, Palo Alto, CA. 37Pediatric Critical Care Medicine, The Children's Hospital at Montefiore, The Pediatric Hospital for Albert Einstein College of Medicine, Bronx, NY. 38Department of Pediatrics, University of British Columbia, Vancouver, BC, Canada. 39Department of Pediatrics, Naval Medical Center San Diego and University of California San Diego School of Medicine, San Diego, CA. 40Department of Pediatrics and Pediatric Critical Care Medicine, The Valley Hospital, Ridgewood, NJ. 41Cardiothoracic ICU, National University Hospital, Singapore. 42Paediatric ICU, The Royal Children's Hospital, Parkville, VIC, Australia. 43Department of Paediatrics, University of Melbourne, Melbourne, VIC, Australia. 44Children's Hospital of Pittsburgh, Pittsburgh, PA. 45Department of Pediatrics, Medical College of Georgia at Augusta University, Augusta, GA. 46Department of Pediatrics, Division of Critical Care Medicine, University of Michigan, Ann Arbor, MI. 47Department of Pharmacy Practice, Loma Linda University School of Pharmacy, Loma Linda, CA. 48Division of Emergency Medicine, Ann and Robert Lurie Children's Hospital of Chicago, Feinberg School of Medicine at Northwestern University, Chicago, IL. 49UCL Great Ormond Street Institute of Child Health and Paediatric Intensive Care Unit, Great Ormond Street Hospital for Children, NHS Trust, London, United Kingdom. 50Pediatric Intensive Care and Emergency Services, Apollo Children's Hospital, Chennai, India. 51Department of Pediatrics, Division of Pediatric Critical Care, Duke University School of Nursing and School of Medicine, Durham, NC. 52Pediatrics School of Medicine, Austral University, Pcia de Buenos Aires, Argentina. 53Departments of Pediatrics and Emergency Medicine, University of Colorado School of Medicine, Aurora, CO. 54Critical Care and Transport, Nemours Children's Hospital, Orlando, FL. 55Department of Pediatrics, Critical Care Medicine, Albert Einstein College of Medicine, Bronx, NY. 56Department of Anesthesiology and Critical Care, The Children's Hospital of Philadelphia, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA. 57Department of Pediatrics, Division of Pediatric Critical Care Medicine, University of Washington School of Medicine, Seattle, WA. 58Departments of Pediatrics & Anesthesiology, Sinai Hospital/NAPA, Baltimore, MD. 59Department of Pediatrics, University of Maryland Medical School, Baltimore, MD.

View Article and Find Full Text PDF
September 2017

Dexmedetomidine for Sedation During Noninvasive Ventilation in Pediatric Patients.

Pediatr Crit Care Med 2017 Sep;18(9):831-837

1Division of Critical Care, Department of Pediatrics, Nationwide Children's Hospital and The Ohio State University College of Medicine, Columbus, OH. 2Emory Sleep Center, Emory University, Atlanta, GA. 3Critical Care Medicine, Children's Healthcare of Atlanta, Children's at Egleston, Atlanta, GA. 4Biostatistics Core, The Research Institute at Nationwide Children's Hospital, Columbus, OH. 5Department of Anesthesiology & Pain Medicine, Nationwide Children's Hospital, Columbus, OH. 6Department of Anesthesiology & Pain Medicine, The Ohio State University College of Medicine, Columbus, OH.

View Article and Find Full Text PDF
September 2017

American College of Critical Care Medicine Clinical Practice Parameters for Hemodynamic Support of Pediatric and Neonatal Septic Shock.

Crit Care Med 2017 06;45(6):1061-1093

1No institution affiliation. 2Department of Critical Care Medicine and Pediatrics, University of Pittsburgh School of Medicine, Pittsburgh, PA. 3Department of Pediatric Critical Care, Riley Hospital for Children, Indiana University, IN. 4Department of Pediatrics, Washington University School of Medicine, St. Louis, MO. 5Department of Pediatrics, Baylor College of Medicine/Texas Children's Hospital, Houston, TX. 6Pediatric Critical Care Medicine, Covenant Women and Children's Hospital, Texas Tech University, Lubbock, TX. 7Division of Pediatric Critical Care Medicine, Department of Pediatrics, Feinberg School of Medicine, Northwestern University, Chicago, IL. 8Division of Pediatric Critical Care, University of British Columbia, Vancouver, BC, Canada. 9Division of Pediatric Critical Care Medicine, Department of Pediatrics, Medical College of Wisconsin, Milwaukee, WI. 10Department of Pediatrics, Baylor College of Medicine, Houston, TX. 11Department of Pediatrics, Saint Barnabas Medical Center, Livingston, NJ. 12Division of Emergency Medicine and Center for Pediatric Clinical Effectiveness, University of Pennsylvania Perelman School of Medicine, Children's Hospital of Philadelphia, Philadelphia, PA. 13Intensive Care & Bioethics, Great Ormond St Hospital for Sick Children, London, United Kingdom. 14Pediatric Critical Care Medicine, Department of Pediatrics, Stollery Children's Hospital/University of Alberta, Edmonton, AB, Canada. 15Division of Pediatric Critical Care Medicine, Department of Pediatrics, Duke Children's, Durham, NC. 16Departments of Pediatrics and Critical Care, Clinical Epidemiology and Biostatistics, McMaster University, Pediatric Intensive Care Unit, McMaster Children's Hospital, Hamilton, ON, Canada. 17Beth Israel Medical Center, Hartsdale, NY. 18Department of Pediatrics and Communicable Diseases, University of Michigan, Ann Arbor, MI. 19Departments of Pediatrics and Biochemistry, Washington University in Saint Louis School of Medicine, Saint Louis, MO. 20Department of Pediatrics, Centre mère-enfant Soleil du CHU de Québec-Université Laval, Québec City, QC, Canada. 21Department of Inpatient Pediatrics, Kaiser Santa Clara Medical Center, Santa Clara, CA. 22Department of Anesthesiology and Critical Care Medicine, University of Pennsylvania Perelman School of Medicine, Children's Hospital of Philadelphia, Philadelphia, PA. 23Division of Pediatric Critical Care Medicine, Department of Pediatrics, University of Mott C.S. Children's Hospital, Ann Arbor, MI. 24Division of Critical Care, Department of Pediatrics, Emory University School of Medicine, Atlanta, GA. 25Department of Pediatrics-Critical Care Medicine, University of Maryland School of Medicine, Baltimore, MD. 26Division of Pediatric Critical Care Medicine, Weill Cornell Medical College, New York, NY. 27Division of Critical Care Medicine, Department of Pediatrics, Nationwide Children's Hospital, Columbus, OH. 28Department of Critical Care Medicine, Children's Mercy Hospital, Kansas City, MO. 29Department of Pediatrics, Texas Tech University Health Sciences Center, El Paso, TX. 30Division of Pediatric Critical Care, University of Florida, Jacksonville, FL. 31Bon Secours St. Mary's Hospital, Glen Allen, VA. 32Division of Pediatric Critical Care, Department of Pediatrics, University of Rochester School of Medicine and Dentistry, Rochester, NY. 33Department of Pediatrics, University of Washington School of Medicine, Seattle, WA. 34Division of Critical Care, Department of Pediatrics, Stanford University School of Medicine, Palo Alto, CA. 35Pediatric Critical Care Medicine, The Children's Hospital at Montefiore, The Pediatric Hospital for Albert Einstein College of Medicine, Bronx, NY. 36Department of Pediatrics, University of British Columbia, UBC & BC Children's Hospital Professor in Critical Care-Global Child Health, Vancouver, BC, Canada. 37Department of Pediatrics, Naval Medical Center San Diego and University of California San Diego School of Medicine, San Diego, CA. 38Department of Pediatrics and Pediatric Critical Care Medicine, The Valley Hospital, Ridgewood, NJ. 39Cardiothoracic ICU, National University Hospital, Singapore. 40Paediatric ICU, The Royal Children's Hospital, Melbourne, Australia. 41Department of Paediatrics, University of Melbourne, Melbourne, Australia. 42Children's Hospital of Pittsburgh, Pittsburgh, PA. 43Department of Pediatrics, Medical College of Georgia at Augusta University, Augusta, GA. 44Division of Critical Care Medicine, Department of Pediatrics, University of Michigan, Ann Arbor, MI. 45Department of Pharmacy Practice, Loma Linda University School of Pharmacy, Loma Linda, CA. 46Division of Emergency Medicine, Ann and Robert Lurie Children's Hospital of Chicago, Feinberg School of Medicine at Northwestern University, Chicago, IL. 47UCL Great Ormond Street Institute of Child Health and Paediatric Intensive Care Unit, Great Ormond Street Hospital for Children, NHS Trust, London, United Kingdom. 48Pediatric Intensive Care and Emergency Services, Apollo Children's Hospital, Chennai, India. 49Division of Pediatric Critical Care, Department of Pediatrics, Duke University School of Nursing and School of Medicine, Durham, NC. 50Pediatrics School of Medicine, Austral University, Pcia de Buenos Aires, Argentina. 51Departments of Pediatrics and Emergency Medicine, University of Colorado School of Medicine, Aurora, CO. 52Critical Care and Transport, Nemours Children's Hospital, Orlando, FL. 53Department of Pediatrics, Critical Care Medicine, Albert Einstein College of Medicine, Bronx, NY. 54Division of Pediatric Critical Care Medicine, Department of Pediatrics, University of Washington School of Medicine, Seattle, WA. 55Departments of Pediatrics & Anesthesiology, Sinai Hospital/NAPA, Baltimore, MD. 56Department of Pediatrics, University of Maryland Medical School, Baltimore, MD.

View Article and Find Full Text PDF
June 2017

Three Hypothetical Inflammation Pathobiology Phenotypes and Pediatric Sepsis-Induced Multiple Organ Failure Outcome.

Pediatr Crit Care Med 2017 06;18(6):513-523

1Department of Critical Care Medicine, Children's Hospital of Pittsburgh and University of Pittsburgh, Pittsburgh, PA. 2Department of Pediatrics, Nationwide Children's Hospital and Ohio State University, Columbus, OH. 3Department of Pediatrics, Texas Children's Hospital and Baylor College of Medicine, Houston, TX. 4Department of Pediatrics, University of Utah, Salt Lake City, UT. 5Department of Medicine, George Washington University Hospital, Washington, DC.

View Article and Find Full Text PDF
June 2017

Pathophysiology of Pediatric Multiple Organ Dysfunction Syndrome.

Pediatr Crit Care Med 2017 Mar;18(3_suppl Suppl 1):S32-S45

1Department of Critical Care Medicine and Pediatrics, University of Pittsburgh, Pittsburgh, PA. 2Department of Anesthesiology and Critical Care, University of Pennsylvania, Philadelphia, PA. 3Department of Pediatrics, Nationwide Children's Hospital, Columbus, OH. 4Department of Pediatrics, University of Michigan, Ann Arbor, MI. 5Department of Pediatrics, Cincinnati Children's Hospital, Cincinnati, OH. 6Department of Pediatrics, Texas Children's Hospital, Houston, TX.

View Article and Find Full Text PDF
March 2017

Pediatric Acute Respiratory Distress Syndrome in Pediatric Allogeneic Hematopoietic Stem Cell Transplants: A Multicenter Study.

Pediatr Crit Care Med 2017 Apr;18(4):304-309

1Division of Critical Care, Department of Pediatrics, Riley Hospital for Children, Indiana University School of Medicine, Indianapolis IN. 2Division of Pediatric Critical Care Medicine, Department of Pediatrics, Seattle Children's Hospital, University of Washington, Seattle, WA. 3Division of Critical Care, Department of Pediatrics, Masonic Children's Hospital, University of Minnesota, Minneapolis, MN. 4Division of Critical Care, Department of Pediatrics, St. Jude's Children's Research Hospital, Memphis, TN. 5Division of Critical Care, Department of Pediatrics, Joseph M Sanzari Children's Hospital at Hackensack University Medical Center, Bergen County, NJ. 6Division of Critical Care, Department of Anesthesia, Children's Hospital of Philadelphia, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA. 7Department of Biostatistics, Indiana University, Indianapolis IN. 8Division of Critical Care, Department of Pediatrics, Weil Cornell Medical College, New York Presbyterian Hospital, New York City, NY. 9Division of Oncology, Department of Pediatrics, Dana-Farber Cancer Institute Harvard University, Boston, MA. 10Division of Oncology, Department of Pediatrics, Children's Hospital at Montefiore, Albert Einstein College of Medicine, Bronx, NY. 11Division of Blood and Marrow Transplant, Department of Pediatrics, Duke Children's Hospital, Duke University, Durham, NC. 12Division of Critical Care, Department of Pediatrics, Nationwide Children's Hospital, The Ohio State University, Columbus, OH. 13Division of Critical Care, Department of Pediatrics, Penn State Hershey Children's Hospital, Pennsylvania State University College of Medicine, Hershey, PA. 14Division of Critical Care, Department of Pediatrics, Duke Children's Hospital, Duke University, Durham, NC.

View Article and Find Full Text PDF
April 2017

Sedation with a remifentanil infusion to facilitate rapid awakening and tracheal extubation in an infant with a potentially compromised airway.

J Pain Res 2016 27;9:871-875. Epub 2016 Oct 27.

Department of Anesthesiology and Pain Medicine, Nationwide Children's Hospital; Department of Anesthesiology and Pain Medicine, The Ohio State University, Columbus, OH, USA.

View Article and Find Full Text PDF
October 2016

Inflammation and innate immune function in critical illness.

Curr Opin Pediatr 2016 06;28(3):267-73

aCritical Care Medicine bThe Research Institute cDepartment of Pediatric Surgery, Nationwide Children's Hospital, Columbus, Ohio, USA.

View Article and Find Full Text PDF
June 2016

Invasive Mechanical Ventilation and Mortality in Pediatric Hematopoietic Stem Cell Transplantation: A Multicenter Study.

Pediatr Crit Care Med 2016 Apr;17(4):294-302

1Department of Pediatrics, Indiana University School of Medicine, Riley Hospital for Children, Indianapolis, IN. 2Department of Pediatrics, Joseph M. Sanzari Children's Hospital at Hackensack University Medical Center, Hackensack, NJ. 3Department of Pediatrics, Medical College of Wisconsin, Children's Hospital of Wisconsin, Milwaukee, WI. 4Department of Anesthesia, Children's Hospital of Philadelphia University of Pennsylvania Perelman School of Medicine, Philadelphia, PA. 5Department of Pediatrics, University of Minnesota Masonic Children's Hospital, Minneapolis, MN. 6Department of Pediatrics, Weill Cornell Medical College, New York Presbyterian Hospital, New York, NY. 7Department of Pediatrics, Dana-Farber Cancer Institute, Boston, MA. 8Department of Pediatrics, Albert Einstein College of Medicine, Children's Hospital at Montefiore, Bronx, NY. 9Department of Pediatrics, University of Washington and Seattle Children's Hospital, Seattle, WA. 10Department of Pediatrics, Duke Children's Hospital, Durham, NC. 11Department of Pediatrics, Nationwide Children's Hospital, Columbus, OH. 12Department of Pediatrics, Pennsylvania State University College of Medicine, Penn State Hershey Children's Hospital, Hershey, PA. 13Department of Public Health, Pennsylvania State University College of Medicine, Penn State Hershey Children's Hospital, Hershey, PA.

View Article and Find Full Text PDF
April 2016

Critical Illness-Induced Immune Suppression: Current State of the Science.

Am J Crit Care 2016 Jan;25(1):85-92

Kristin C. Greathouse is a doctoral student in nursing at The Ohio State University and an advanced practice nurse in the Cardiothoracic Intensive Care Unit at Nationwide Children's Hospital, Columbus, OH. Mark W. Hall is the chief of the Division of Critical Care Medicine at Nationwide Children's Hospital and an immunobiology researcher in the Center for Clinical and Translational Research at The Research Institute at Nationwide Children's Hospital, Columbus, OH.

View Article and Find Full Text PDF
January 2016

Immunologic and Infectious Diseases in Pediatric Cardiac Critical Care: Proceedings of the 10th International Pediatric Cardiac Intensive Care Society Conference.

World J Pediatr Congenit Heart Surg 2015 Oct;6(4):575-87

Section of Critical Care Medicine and Cardiology, Baylor College of Medicine, Texas Children's Hospital, Houston, TX, USA.

View Article and Find Full Text PDF
October 2015

Nasopharyngeal bacterial burden and antibiotics: Influence on inflammatory markers and disease severity in infants with respiratory syncytial virus bronchiolitis.

J Infect 2015 Oct 3;71(4):458-69. Epub 2015 Jul 3.

Center for Vaccines and Immunity, The Research Institute at Nationwide Children's Hospital, Columbus, OH, USA; Division of Infectious Diseases, Nationwide Children's Hospital and The Ohio State University School of Medicine, Columbus, OH, USA. Electronic address:

View Article and Find Full Text PDF
October 2015

Adjunctive and novel therapies for sepsis.

J Pediatr Intensive Care 2014 Dec 28;3(4):255-267. Epub 2015 Jul 28.

Division of Critical Care Medicine, Nationwide Children's Hospital, Columbus, OH, USA.

View Article and Find Full Text PDF
December 2014

An empiric antibiotic protocol using risk stratification improves antibiotic selection and timing in critically ill children.

Ann Am Thorac Soc 2014 Dec;11(10):1569-75

1 Department of Pediatrics, Nationwide Children's Hospital/The Ohio State University College of Medicine, Columbus, Ohio; and.

View Article and Find Full Text PDF
December 2014

Red blood cell transfusion and immune function in critically ill children: a prospective observational study.

Transfusion 2015 Apr 29;55(4):766-74. Epub 2014 Oct 29.

Pediatric Critical Care Medicine, Department of Pediatrics, Nationwide Children's Hospital, Columbus, Ohio.

View Article and Find Full Text PDF
April 2015

Innate immune function predicts the development of nosocomial infection in critically injured children.

Shock 2014 Oct;42(4):313-21

*Pediatric Critical Care Medicine, Department of Pediatrics, and †The Research Institute, Nationwide Children's Hospital, Columbus, Ohio; ‡Critical Care Medicine, Department of Pediatrics, Akron Children's Hospital, Akron, Ohio; §Department of Pathology, Nationwide Children's Hospital, Columbus, Ohio; and ║Pediatric Surgery, Nationwide Children's Hospital, Columbus, Ohio; ¶Department of Neurological Surgery, University of California, San Francisco, San Francisco, California; and **Division of Hematology, The Ohio State University College of Medicine, Columbus; ††Emergency Medicine, Department of Pediatrics, Akron Children's Hospital, Akron, Ohio.

View Article and Find Full Text PDF
October 2014

Reply to Plötz et al.

J Infect Dis 2013 Dec 16;208(11):1924-5. Epub 2013 Sep 16.

Center for Vaccines and Immunity, The Research Institute at Nationwide Children's Hospital, The Ohio State University College of Medicine, Columbus.

View Article and Find Full Text PDF
December 2013

Extracorporeal membrane oxygenation and cerebral blood flow velocity in children.

Pediatr Crit Care Med 2013 Mar;14(3):e126-34

Both authors: Nationwide Children's Hospital, Columbus, OH, USA.

View Article and Find Full Text PDF
March 2013

Innate immune dysfunction is associated with enhanced disease severity in infants with severe respiratory syncytial virus bronchiolitis.

J Infect Dis 2013 Feb 29;207(4):564-73. Epub 2012 Nov 29.

Center for Vaccines and Immunity, The Research Institute at Nationwide Children's Hospital, The Ohio State University School of Medicine, Columbus, OH 43205, USA.

View Article and Find Full Text PDF
February 2013

Clinical implications and molecular mechanisms of immunoparalysis after cardiopulmonary bypass.

J Thorac Cardiovasc Surg 2012 May 11;143(5):1160-1166.e1. Epub 2011 Oct 11.

Division of Critical Care Medicine, C.S. Mott Children’s Hospital, F-6882, 1500 East Medical Center Dr, Ann Arbor, MI 48109-0243, USA.

View Article and Find Full Text PDF
May 2012

Immunoparalysis and nosocomial infection in children with multiple organ dysfunction syndrome.

Intensive Care Med 2011 Mar 10;37(3):525-32. Epub 2010 Dec 10.

Department of Pediatrics, Section of Critical Care Medicine, The Ohio State University College of Medicine, Columbus, OH, USA.

View Article and Find Full Text PDF
March 2011

Failure to recover somatotropic axis function is associated with mortality from pediatric sepsis-induced multiple organ dysfunction syndrome.

Pediatr Crit Care Med 2010 Jan;11(1):18-25

Section of Critical Care Medicine, Department of Pediatrics, Ohio State University College of Medicine, Columbus, OH, USA.

View Article and Find Full Text PDF
January 2010

Pyrin critical to macrophage IL-1beta response to Francisella challenge.

J Immunol 2009 Jun;182(12):7982-9

Division of Pulmonary Allergy Critical Care and Sleep Medicine, Davis Heart and Lung Research Institute, Ohio State University, Columbus, OH 43210, USA.

View Article and Find Full Text PDF
June 2009

Serotonin syndrome following a single 50 mg dose of sertraline in a child.

Clin Toxicol (Phila) 2008 Nov;46(9):845-9

The Ohio State University, College of Pharmacy, The Research Institute at Nationwide Children's Hospital, The Ohio State University, Columbus, Ohio 43210, USA.

View Article and Find Full Text PDF
November 2008

Immunoparalysis and adverse outcomes from critical illness.

Pediatr Clin North Am 2008 Jun;55(3):647-68, xi

Critical Care Medicine, Nationwide Children's Hospital, 700 Children's Drive, Columbus, OH 43205, USA.

View Article and Find Full Text PDF
June 2008

Bacterial peptide recognition and immune activation facilitated by human peptide transporter PEPT2.

Am J Respir Cell Mol Biol 2008 Nov 12;39(5):536-42. Epub 2008 May 12.

Department of Pharmaceutical Sciences, University of Maryland, Baltimore, MD, USA.

View Article and Find Full Text PDF
November 2008

Monocyte mRNA phenotype and adverse outcomes from pediatric multiple organ dysfunction syndrome.

Pediatr Res 2007 Nov;62(5):597-603

Department of Pediatrics, Davis Heart and Lung Research Institute, The Ohio State University College of Medicine, Columbus, Ohio 43210, USA.

View Article and Find Full Text PDF
November 2007

Rapid fluid resuscitation in pediatrics: testing the American College of Critical Care Medicine guideline.

Ann Emerg Med 2007 Nov 30;50(5):601-7. Epub 2007 Aug 30.

Section of Emergency Medicine, Columbus Children's Hospital, Columbus, OH 43205, USA.

View Article and Find Full Text PDF
November 2007

Caspase-1 regulates Escherichia coli sepsis and splenic B cell apoptosis independently of interleukin-1beta and interleukin-18.

Am J Respir Crit Care Med 2006 Nov 14;174(9):1003-10. Epub 2006 Aug 14.

Davis Heart and Lung Research Institute, The Ohio State University, Columbus, OH 43210, USA.

View Article and Find Full Text PDF
November 2006

Internalization and phagosome escape required for Francisella to induce human monocyte IL-1beta processing and release.

Proc Natl Acad Sci U S A 2006 Jan 22;103(1):141-6. Epub 2005 Dec 22.

Davis Heart and Lung Research Institute, Department of Molecular Virology and Immunology and Medical Genetics, and Center for Microbial Interface Biology, Ohio State University, Columbus, OH 43210, USA.

View Article and Find Full Text PDF
January 2006

Prolonged lymphopenia, lymphoid depletion, and hypoprolactinemia in children with nosocomial sepsis and multiple organ failure.

J Immunol 2005 Mar;174(6):3765-72

Department of Critical Care Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA.

View Article and Find Full Text PDF
March 2005

Janus kinase 3 down-regulates lipopolysaccharide-induced IL-1 beta-converting enzyme activation by autocrine IL-10.

J Immunol 2004 Apr;172(8):4948-55

Division of Pulmonary and Critical Care Medicine, and Davis Heart and Lung Research Institute, Ohio State University, Columbus, OH 43210, USA.

View Article and Find Full Text PDF
April 2004