Mark Ultsch

Mark Ultsch

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Mark Ultsch

Mark Ultsch

Publications by authors named "Mark Ultsch"

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46Publications

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Discovery of a cryptic peptide-binding site on PCSK9 and design of antagonists.

Nat Struct Mol Biol 2017 Oct 21;24(10):848-856. Epub 2017 Aug 21.

Department of Early Discovery Biochemistry, Genentech, Inc., South San Francisco, California, USA.

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http://www.nature.com/doifinder/10.1038/nsmb.3453
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http://dx.doi.org/10.1038/nsmb.3453DOI Listing
October 2017

Developments in the Implementation of Acoustic Droplet Ejection for Protein Crystallography.

J Lab Autom 2016 Feb 14;21(1):97-106. Epub 2015 Aug 14.

Department of Structural Biology, Genentech, Inc, South San Francisco, CA, USA

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http://dx.doi.org/10.1177/2211068215598938DOI Listing
February 2016

Antiparallel conformation of knob and hole aglycosylated half-antibody homodimers is mediated by a CH2-CH3 hydrophobic interaction.

J Mol Biol 2014 May 24;426(9):1947-57. Epub 2014 Feb 24.

Department of Protein Chemistry, Genentech Research and Early Development, 1 DNA Way, South San Francisco, CA 94080, USA. Electronic address:

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http://dx.doi.org/10.1016/j.jmb.2014.02.015DOI Listing
May 2014

Structural basis of signaling blockade by anti-IL-13 antibody Lebrikizumab.

J Mol Biol 2013 Apr 25;425(8):1330-9. Epub 2013 Jan 25.

Department of Structural Biology, Genentech Inc., 1 DNA Way, South San Francisco, CA 94080, USA.

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http://dx.doi.org/10.1016/j.jmb.2013.01.024DOI Listing
April 2013

Structural and functional analysis of HtrA1 and its subdomains.

Structure 2012 Jun 10;20(6):1040-50. Epub 2012 May 10.

Department of Structural Biology, Genentech, Inc., South San Francisco, CA 94080, USA.

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http://dx.doi.org/10.1016/j.str.2012.03.021DOI Listing
June 2012

A new regulatory switch in a JAK protein kinase.

Proteins 2011 Feb;79(2):393-401

Department of Discovery Chemistry, Genentech, Inc, South San Francisco, California 94080, USA.

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http://doi.wiley.com/10.1002/prot.22889
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http://dx.doi.org/10.1002/prot.22889DOI Listing
February 2011

Structure of the complex between HER2 and an antibody paratope formed by side chains from tryptophan and serine.

J Mol Biol 2010 Sep 21;402(1):217-29. Epub 2010 Jul 21.

Department of Protein Engineering, Genentech, Inc., 1 DNA Way, South San Francisco, CA 94080, USA.

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http://dx.doi.org/10.1016/j.jmb.2010.07.027DOI Listing
September 2010

Structural basis for high-affinity HER2 receptor binding by an engineered protein.

Proc Natl Acad Sci U S A 2010 Aug 9;107(34):15039-44. Epub 2010 Aug 9.

Department of Structural Biology, Genentech Inc, 1 DNA Way, South San Francisco, CA 94080, USA.

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http://dx.doi.org/10.1073/pnas.1005025107DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2930565PMC
August 2010

Structure-function studies of two synthetic anti-vascular endothelial growth factor Fabs and comparison with the Avastin Fab.

J Biol Chem 2006 Mar 22;281(10):6625-31. Epub 2005 Dec 22.

Department of Protein Engineering, Genentech, Inc., South San Francisco, California 94080, USA.

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http://dx.doi.org/10.1074/jbc.M507783200DOI Listing
March 2006

Intramolecular cooperativity in a protein binding site assessed by combinatorial shotgun scanning mutagenesis.

J Mol Biol 2005 Apr;347(3):489-94

Department of Biochemistry and Molecular Biology and Institute for Biophysical Dynamics, Cummings Life Sciences Center, University of Chicago, 920 East 58th Street, Chicago, IL 60637, USA.

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http://linkinghub.elsevier.com/retrieve/pii/S002228360500073
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http://dx.doi.org/10.1016/j.jmb.2005.01.040DOI Listing
April 2005

Bcl10 activates the NF-kappaB pathway through ubiquitination of NEMO.

Nature 2004 Jan 24;427(6970):167-71. Epub 2003 Dec 24.

Department of Molecular Oncology, Genentech Inc. 1 DNA Way, South San Francisco, California 94080, USA.

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http://dx.doi.org/10.1038/nature02273DOI Listing
January 2004