Mark T Gladwin

Mark T Gladwin

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Mark T Gladwin

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Vascular TSP1-CD47 signaling promotes sickle cell-associated arterial vasculopathy and pulmonary hypertension in mice.

Am J Physiol Lung Cell Mol Physiol 2019 Jun 20;316(6):L1150-L1164. Epub 2019 Mar 20.

Heart, Lung, Blood, and Vascular Medicine Institute and Division of Hematology/Oncology, UPMC Department of Medicine, University of Pittsburgh , Pittsburgh, Pennsylvania.

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http://dx.doi.org/10.1152/ajplung.00302.2018DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6620668PMC
June 2019

Pulmonary vascular disease in the setting of heart failure with preserved ejection fraction.

Trends Cardiovasc Med 2019 05 17;29(4):207-217. Epub 2018 Aug 17.

Pittsburgh Heart, Lung, Blood and Vascular Medicine Institute, University of Pittsburgh, Pittsburgh, PA 15213, United States; Pulmonary, Allergy and Critical Care Medicine, University of Pittsburgh, Pittsburgh, PA 15213, United States. Electronic address:

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http://dx.doi.org/10.1016/j.tcm.2018.08.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6378124PMC
May 2019

Nox1/Ref-1-mediated activation of CREB promotes Gremlin1-driven endothelial cell proliferation and migration.

Redox Biol 2019 04 8;22:101138. Epub 2019 Feb 8.

Vascular Medicine Institute, University of Pittsburgh, 200 Lothrop St., Pittsburgh, PA 15261, United States; Department of Pharmacology and Chemical Biology, University of Pittsburgh, 200 Lothrop St., Pittsburgh, PA 15261, United States. Electronic address:

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http://dx.doi.org/10.1016/j.redox.2019.101138DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6395885PMC
April 2019

Sleep phenotype in the Townes mouse model of sickle cell disease.

Sleep Breath 2019 Mar 29;23(1):333-339. Epub 2018 Aug 29.

Division of Pulmonary, Allergy and Critical Care Medicine, University of Pittsburgh School of Medicine, 3459 Fifth Avenue, MUH 628 NW, Pittsburgh, PA, 15213, USA.

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http://link.springer.com/10.1007/s11325-018-1711-x
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http://dx.doi.org/10.1007/s11325-018-1711-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6418068PMC
March 2019

Insights into the pulmonary vascular complications of heart failure with preserved ejection fraction.

J Physiol 2019 Feb 30;597(4):1143-1156. Epub 2018 Dec 30.

Pittsburgh Heart, Lung, Blood and Vascular Medicine Institute, University of Pittsburgh, Pittsburgh, PA, USA.

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http://dx.doi.org/10.1113/JP275858DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6376073PMC
February 2019

Nitrite and nitrate chemical biology and signalling.

Br J Pharmacol 2019 Jan 3;176(2):228-245. Epub 2018 Oct 3.

Heart, Lung, Blood, and Vascular Medicine Institute, University of Pittsburgh, Pittsburgh, PA, USA.

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http://doi.wiley.com/10.1111/bph.14484
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http://dx.doi.org/10.1111/bph.14484DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6295445PMC
January 2019

Pathophysiology of Sickle Cell Disease.

Annu Rev Pathol 2019 Jan 17;14:263-292. Epub 2018 Oct 17.

Pittsburgh Heart, Lung and Blood Vascular Medicine Institute, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15261, USA.

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http://dx.doi.org/10.1146/annurev-pathmechdis-012418-012838DOI Listing
January 2019

Sources of Vascular Nitric Oxide and Reactive Oxygen Species and Their Regulation

Physiol Rev 2019 01;99(1):311-379

Pittsburgh Heart, Lung, Blood and Vascular Medicine Institute, University of Pittsburgh , Pittsburgh, Pennsylvania ; Pulmonary, Allergy and Critical Care Medicine, University of Pittsburgh , Pittsburgh, Pennsylvania ; Department of Pharmacology and Chemical Biology, University of Pittsburgh , Pittsburgh, Pennsylvania ; and Department of Medicine, Center for Metabolism and Mitochondrial Medicine, University of Pittsburgh , Pittsburgh, Pennsylvania.

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https://www.physiology.org/doi/10.1152/physrev.00036.2017
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http://dx.doi.org/10.1152/physrev.00036.2017DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6442925PMC
January 2019

Erythrocytic bioactivation of nitrite and its potentiation by far-red light.

Redox Biol 2019 01 3;20:442-450. Epub 2018 Nov 3.

Department of Physics,Translational Science Center, Wake Forest University, Winston-Salem, NC 27109, United States; Department of Biomedical Engineering, Wake Forest University School of Medicine, Winston-Salem, NC 27157, United States. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S22132317183092
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http://dx.doi.org/10.1016/j.redox.2018.11.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6230921PMC
January 2019

Frequent blood donations alter susceptibility of red blood cells to storage- and stress-induced hemolysis.

Transfusion 2019 01 26;59(1):67-78. Epub 2018 Nov 26.

Blood Research Institute, Blood Center of Wisconsin, and Department of Cell Biology, Neurobiology and Anatomy, Medical College of Wisconsin, Milwaukee.

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http://dx.doi.org/10.1111/trf.14998DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6347021PMC
January 2019

Hemolysis-mediated Toxicity during Cardiopulmonary Bypass Ameliorated by Inhaled Nitric Oxide Gas.

Am J Respir Crit Care Med 2018 Nov;198(10):1244-1246

1 Pittsburgh Heart, Lung, and Blood Vascular Medicine Institute University of Pittsburgh School of Medicine Pittsburgh, Pennsylvania.

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http://dx.doi.org/10.1164/rccm.201806-1165EDDOI Listing
November 2018

Hemolysis and hemolysis-related complications in females vs. males with sickle cell disease.

Am J Hematol 2018 Nov 17;93(11):E376-E380. Epub 2018 Oct 17.

Division of Hematology and Oncology, Department of Medicine, Comprehensive Sickle Cell Center, University of Illinois at Chicago, Chicago, Illinois.

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http://dx.doi.org/10.1002/ajh.25258DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6196103PMC
November 2018

Escorting α-globin to eNOS: α-globin-stabilizing protein paves the way.

J Clin Invest 2018 Nov 8;128(11):4755-4757. Epub 2018 Oct 8.

Pittsburgh Heart, Lung, Blood and Vascular Medicine Institute.

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https://www.jci.org/articles/view/124302
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http://dx.doi.org/10.1172/JCI124302DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6205368PMC
November 2018

Left Ventricular Ejection Fraction Cut Point of 50% for Heart Failure With Preserved Ejection Fraction-Reply.

JAMA Cardiol 2018 Oct;3(10):1023-1024

Pittsburgh Heart, Lung, Blood, and Vascular Medicine Institute, University of Pittsburgh, Pittsburgh, Pennsylvania.

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http://dx.doi.org/10.1001/jamacardio.2018.1936DOI Listing
October 2018

Apixaban or Rivaroxaban Versus Warfarin for Treatment of Submassive Pulmonary Embolism After Catheter-Directed Thrombolysis.

Clin Appl Thromb Hemost 2018 Sep 18;24(6):908-913. Epub 2018 Feb 18.

6 Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.

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http://journals.sagepub.com/doi/10.1177/1076029618755311
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http://dx.doi.org/10.1177/1076029618755311DOI Listing
September 2018

Nitrosyl Myoglobins and Their Nitrite Precursors: Crystal Structural and Quantum Mechanics and Molecular Mechanics Theoretical Investigations of Preferred Fe -NO Ligand Orientations in Myoglobin Distal Pockets.

Biochemistry 2018 08 27;57(32):4788-4802. Epub 2018 Jul 27.

Price Family Foundation Institute of Structural Biology and Department of Chemistry and Biochemistry , University of Oklahoma , 101 Stephenson Parkway , Norman , Oklahoma 73019 , United States.

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http://dx.doi.org/10.1021/acs.biochem.8b00542DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6474360PMC
August 2018

Experimental intravascular hemolysis induces hemodynamic and pathological pulmonary hypertension: association with accelerated purine metabolism.

Pulm Circ 2018 Jul-Sep;8(3):2045894018791557. Epub 2018 Jul 13.

1 Division of Pulmonary, Allergy and Critical Care Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.

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http://dx.doi.org/10.1177/2045894018791557DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6080084PMC
July 2018

Emerging therapeutics in pulmonary hypertension.

Am J Physiol Lung Cell Mol Physiol 2018 05 1;314(5):L769-L781. Epub 2018 Feb 1.

Pittsburgh Heart, Lung, Blood and Vascular Medicine Institute, University of Pittsburgh , Pittsburgh, Pennsylvania.

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http://dx.doi.org/10.1152/ajplung.00259.2017DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6008125PMC
May 2018

Nitric oxide pathology and therapeutics in sickle cell disease.

Clin Hemorheol Microcirc 2018 ;68(2-3):223-237

Heart, Lung, Blood and Vascular Medicine Institute, University of Pittsburgh and University of Pittsburgh Medical Center, Pittsburgh, PA, USA.

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http://dx.doi.org/10.3233/CH-189009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5911689PMC
May 2018

Redefining pulmonary hypertension.

Lancet Respir Med 2018 03 18;6(3):168-170. Epub 2017 Dec 18.

Department of Medicine, University of Pittsburgh Medical Center and Pittsburgh Heart, Lung, Blood, and Vascular Medical Institute, University of Pittsburgh, Pittsburgh, PA, USA.

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http://dx.doi.org/10.1016/S2213-2600(17)30498-8DOI Listing
March 2018

Under Pressure to Clarify Pulmonary Hypertension Clinical Risk.

Am J Respir Crit Care Med 2018 02;197(4):423-426

4 University of Pittsburgh Medical Center and.

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http://dx.doi.org/10.1164/rccm.201711-2306EDDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5821912PMC
February 2018

Erythrocytes and Vascular Function: Oxygen and Nitric Oxide.

Front Physiol 2018 22;9:125. Epub 2018 Feb 22.

Physics Department, Wake Forest University, Winston-Salem, NC, United States.

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http://dx.doi.org/10.3389/fphys.2018.00125DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5826969PMC
February 2018

Hemoglobin α in Pulmonary Endothelium: Ironing Out Nitric Oxide Signaling.

Am J Respir Cell Mol Biol 2017 12;57(6):639-641

1 Pittsburgh Heart, Lung, Blood and Vascular Medicine Institute University of Pittsburgh Pittsburgh, Pennsylvania and.

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http://dx.doi.org/10.1165/rcmb.2017-0272EDDOI Listing
December 2017

Cardiovascular complications in patients with sickle cell disease.

Authors:
Mark T Gladwin

Hematology Am Soc Hematol Educ Program 2017 12;2017(1):423-430

Pittsburgh Heart, Lung, Blood and Vascular Medicine Institute, University of Pittsburgh, Pittsburgh, PA; Heart and Vascular Institute, UPMC, Pittsburgh, PA; and Division of Pulmonary, Allergy and Critical Care Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA.

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http://dx.doi.org/10.1182/asheducation-2017.1.423DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6142571PMC
December 2017

What is the role of screening for pulmonary hypertension in adults and children with sickle cell disease?

Hematology Am Soc Hematol Educ Program 2017 12;2017(1):431-434

Pittsburgh Heart, Lung, Blood and Vascular Medicine Institute, Division of Pulmonary, Allergy and Critical Care Medicine, University of Pittsburgh and University of Pittsburgh Medical Center, Pittsburgh, PA.

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http://dx.doi.org/10.1182/asheducation-2017.1.431DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6142565PMC
December 2017

Cell-Free Plasma Hemoglobin and Male Gender Are Risk Factors for Acute Kidney Injury in Low Risk Children Undergoing Cardiopulmonary Bypass.

Crit Care Med 2017 Nov;45(11):e1123-e1130

1Department of Critical Care Medicine, UPMC and University of Pittsburgh, Pittsburgh, PA. 2Department of Emergency Medicine, UPMC and University of Pittsburgh, Pittsburgh, PA. 3Safar Center for Resuscitation Research, University of Pittsburgh, Pittsburgh, PA. 4Department of Cardiothoracic Surgery, UPMC and University of Pittsburgh, Pittsburgh, PA. 5Department of Cardiovascular Services, Nemours Children's Hospital, Orlando, FL. 6Pittsburgh Heart, Lung, Blood and Vascular Medicine Institute, University of Pittsburgh, Pittsburgh, PA. 7Department of Medicine UPMC and University of Pittsburgh, Pittsburgh, PA.

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http://dx.doi.org/10.1097/CCM.0000000000002703DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5657595PMC
November 2017

Cytoglobin at the Crossroads of Vascular Remodeling.

Arterioscler Thromb Vasc Biol 2017 10;37(10):1803-1805

From the Heart, Lung, Blood, and Vascular Medicine Institute, Department of Medicine (M.B.A., A.W.D., J.T., M.T.G.), Department of Bioengineering (M.B.A.), and Division of Pulmonary, Allergy, and Critical Care Medicine (A.W.D., J.T., M.T.G.), University of Pittsburgh, PA.

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http://dx.doi.org/10.1161/ATVBAHA.117.310058DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5822687PMC
October 2017

Conjugated Linoleic Acid Modulates Clinical Responses to Oral Nitrite and Nitrate.

Hypertension 2017 09;70(3):634-644

From the Department of Pediatrics, Division of Pediatric Endocrinology and Diabetes (K.S.H.), Pittsburgh Heart, Lung, Blood, and Vascular Medicine Institute (K.S.H., S.G.W., M.D.-G., N.H., C.C., S.S., B.A.F., M.T.G.), Department of Pharmacology and Chemical Biology (S.G.W., M.D.-G., S.S., B.A.F.), Department of Medicine, Division of Endocrinology (N.H., B.G.), and Department of Medicine, Division of Pulmonary, Allergy, and Critical Care Medicine, University of Pittsburgh, PA (M.T.G.); Department of Physics, Wake Forest University, Winston Salem, NC (L.B., D.B.K.-S.); and Pharmaceutical Development Section, Department of Pharmacy, Clinical Center, National Institutes of Health, Bethesda, MD (G.P., G.G.).

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http://dx.doi.org/10.1161/HYPERTENSIONAHA.117.09016DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5783786PMC
September 2017

A 53-Year-Old Woman with Severe Carbon Monoxide Poisoning.

Ann Am Thorac Soc 2017 09;14(9):1475-1478

1 Pittsburgh Heart, Lung, Blood, and Vascular Medicine Institute, University of Pittsburgh, Pittsburgh, Pennsylvania.

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http://dx.doi.org/10.1513/AnnalsATS.201701-002CCDOI Listing
September 2017

Potential therapeutic action of nitrite in sickle cell disease.

Redox Biol 2017 08 10;12:1026-1039. Epub 2017 May 10.

Department of Physics, Wake Forest University, Winston-Salem, NC 27109, United States; Translational Science Center, Wake Forest University, Winston-Salem, NC 27109, United States. Electronic address:

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http://dx.doi.org/10.1016/j.redox.2017.05.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5430577PMC
August 2017

Efficient Reduction of Vertebrate Cytoglobins by the Cytochrome b/Cytochrome b Reductase/NADH System.

Biochemistry 2017 08 19;56(30):3993-4004. Epub 2017 Jul 19.

Heart, Lung, Blood, and Vascular Medicine Institute, University of Pittsburgh , Pittsburgh, Pennsylvania 15213, United States.

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http://dx.doi.org/10.1021/acs.biochem.7b00224DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5555378PMC
August 2017

Do BRD(4)S of a Feather Flock Together? How an Inflammation-Driven Epigenetic Regulator May Link Pulmonary Hypertension and Coronary Artery Disease.

Arterioscler Thromb Vasc Biol 2017 08;37(8):1428-1430

From the Pittsburgh Heart, Lung, Blood and Vascular Medicine Institute, University of Pittsburgh, PA (P.D., D.G., M.T.G.); Division of Cardiology (P.D., D.G.) and Division of Pulmonary, Allergy and Critical Care Medicine (M.T.G.), University of Pittsburgh School of Medicine, PA; and Heart and Vascular Institute, UPMC, Pittsburgh, PA (M.T.G.).

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https://www.ahajournals.org/doi/10.1161/ATVBAHA.117.309632
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http://dx.doi.org/10.1161/ATVBAHA.117.309632DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5572573PMC
August 2017

Cytochrome b5 Reductase 3 Modulates Soluble Guanylate Cyclase Redox State and cGMP Signaling.

Circ Res 2017 Jul 5;121(2):137-148. Epub 2017 Jun 5.

From the Heart, Lung, Blood and Vascular Medicine Institute (M.M.R., A.T.N., M.P.M., S.A.H., C.S.-W., N.T.C., N.C.-M., K.C.W., M.T.G., A.C.S.), Division of Pulmonary, Allergy and Critical Care Medicine (C.S.-W., M.T.G.), Department of Pharmacology and Chemical Biology (S.J., C.J.B., F.J.S., A.C.S.), and Division of Renal-Electrolyte (C.J.B.), University of Pittsburgh, PA; Department of Physiology and Pharmacology, West Virginia University School of Medicine, Morgantown (E.E.K.); and Department of Internal Medicine, Division of Cardiology, University of Texas Houston Medical School (E.M.).

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http://dx.doi.org/10.1161/CIRCRESAHA.117.310705DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5527687PMC
July 2017

Enterosalivary nitrate metabolism and the microbiome: Intersection of microbial metabolism, nitric oxide and diet in cardiac and pulmonary vascular health.

Free Radic Biol Med 2017 04 16;105:48-67. Epub 2016 Dec 16.

Division of Pulmonary, Allergy and Critical Care Medicine, Department of Medicine, University of Pittsburgh Medical Center, Pittsburgh, PA 15261, USA; Pittsburgh Heart, Lung, Blood and Vascular Medicine Institute, University of Pittsburgh, Pittsburgh PA 15261, USA; Department of Pharmacology and Chemical Biology, University of Pittsburgh, Pittsburgh, PA 15261, USA; Department of Physiology and Pharmacology, Karolinska Institutet, S-17177 Stockholm, Sweden.

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http://dx.doi.org/10.1016/j.freeradbiomed.2016.12.015DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5401802PMC
April 2017

Carbon Monoxide Poisoning: Pathogenesis, Management, and Future Directions of Therapy.

Am J Respir Crit Care Med 2017 03;195(5):596-606

1 Pittsburgh Heart, Lung, Blood and Vascular Medicine Institute.

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http://dx.doi.org/10.1164/rccm.201606-1275CIDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5363978PMC
March 2017

Reply: Better Studies Are Needed to Guide Treatment of Carbon Monoxide Poisoning.

Am J Respir Crit Care Med 2017 03;195(5):694-695

1 University of Pittsburgh Pittsburgh, Pennsylvania.

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http://dx.doi.org/10.1164/rccm.201612-2463LEDOI Listing
March 2017

Translational Advances in the Field of Pulmonary Hypertension Bench to Bedside: How Fundamental Discoveries in Science Are Advancing Our Understanding and Therapy of Pulmonary Arterial Hypertension.

Authors:
Mark T Gladwin

Am J Respir Crit Care Med 2017 01;195(1):1-3

1 Pittsburgh Heart, Lung, Blood, and Vascular Medicine Institute University of Pittsburgh and University of Pittsburgh Medical Center Pittsburgh, Pennsylvania.

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http://dx.doi.org/10.1164/rccm.201608-1637EDDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5214923PMC
January 2017

How Red Blood Cells Process Nitric Oxide: Evidence for the Nitrite Hypothesis.

Authors:
Mark T Gladwin

Circulation 2017 01;135(2):177-179

From Pittsburgh Heart, Lung, Blood, and Vascular Medicine Institute, University of Pittsburgh, Pittsburgh, PA; and Division of Pulmonary, Allergy and Critical Care Medicine, and Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA.

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http://dx.doi.org/10.1161/CIRCULATIONAHA.116.024752DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5385839PMC
January 2017

Lung vaso-occlusion in sickle cell disease mediated by arteriolar neutrophil-platelet microemboli.

JCI Insight 2017 01 12;2(1):e89761. Epub 2017 Jan 12.

Pittsburgh Heart, Lung and Blood Vascular Medicine Institute, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA.

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http://dx.doi.org/10.1172/jci.insight.89761DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5214368PMC
January 2017

Testosterone-dependent sex differences in red blood cell hemolysis in storage, stress, and disease.

Transfusion 2016 Oct 9;56(10):2571-2583. Epub 2016 Aug 9.

Pittsburgh Heart, Lung, Blood, and Vascular Medicine Institute, University of Pittsburgh, Pittsburgh, Pennsylvania.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5065383PMC
http://dx.doi.org/10.1111/trf.13745DOI Listing
October 2016

AltitudeOmics: Red Blood Cell Metabolic Adaptation to High Altitude Hypoxia.

J Proteome Res 2016 10 27;15(10):3883-3895. Epub 2016 Sep 27.

Altitude Research Center, Department of Emergency Medicine, University of Colorado , Anschutz Medical Campus, Aurora, Colorado, United States.

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http://dx.doi.org/10.1021/acs.jproteome.6b00733DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5512539PMC
October 2016

Automated Measurement of Blood Vessels in Tissues from Microscopy Images.

Curr Protoc Cytom 2016 10 10;78:12.44.1-12.44.13. Epub 2016 Oct 10.

Department of Medicine, University of Pittsburgh and University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania.

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http://dx.doi.org/10.1002/cpcy.10DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6431235PMC
October 2016

Sickle Cell Trait Increases Red Blood Cell Storage Hemolysis and Post-Transfusion Clearance in Mice.

EBioMedicine 2016 Sep 4;11:239-248. Epub 2016 Aug 4.

Pittsburgh Heart, Lung, Blood and Vascular Medicine Institute, University of Pittsburgh, Pittsburgh, PA, United States; Division of Pulmonary, Allergy and Critical Care Medicine, University of Pittsburgh, Pittsburgh, PA, United States; Department of Molecular Pharmacology and Chemical Biology, University of Pittsburgh, Pittsburgh, PA, United States. Electronic address:

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5049931PMC
http://dx.doi.org/10.1016/j.ebiom.2016.08.006DOI Listing
September 2016

Response by Lai and Gladwin to Letter Regarding Article, "SIRT3-AMP-Activated Protein Kinase Activation by Nitrite and Metformin Improves Hyperglycemia and Normalizes Pulmonary Hypertension Associated With Heart Failure With Preserved Ejection Fraction".

Circulation 2016 Aug;134(6):e79-80

From Pittsburgh Heart, Lung, Blood and Vascular Medicine Institute, and Division of Pulmonary, Allergy and Critical Care Medicine, University of Pittsburgh, PA.

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http://dx.doi.org/10.1161/CIRCULATIONAHA.116.023201DOI Listing
August 2016

Globin X is a six-coordinate globin that reduces nitrite to nitric oxide in fish red blood cells.

Proc Natl Acad Sci U S A 2016 07 12;113(30):8538-43. Epub 2016 Jul 12.

Pittsburgh Heart, Lung, Blood, and Vascular Medicine Institute, University of Pittsburgh, Pittsburgh, PA 15213; Division of Pulmonary, Allergy, and Critical Care Medicine, University of Pittsburgh, Pittsburgh, PA 15213;

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http://dx.doi.org/10.1073/pnas.1522670113DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4968712PMC
July 2016

Metabolic Syndrome and the Lung.

Chest 2016 06 20;149(6):1525-34. Epub 2016 Jan 20.

Department of Medicine, University of Pittsburgh, Pittsburgh, PA. Electronic address:

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http://dx.doi.org/10.1016/j.chest.2015.12.034DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4944780PMC
June 2016

Update in Pulmonary Vascular Disease 2015.

Am J Respir Crit Care Med 2016 06;193(12):1337-44

4 Division of Cardiology, Department of Medicine, University of Pittsburgh Medical Center and Pittsburgh Heart, Lung, Blood and Vascular Medicine Institute, University of Pittsburgh, Pittsburgh, Pennsylvania.

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http://dx.doi.org/10.1164/rccm.201601-0143UPDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4910895PMC
June 2016

Cardiovascular complications and risk of death in sickle-cell disease.

Authors:
Mark T Gladwin

Lancet 2016 Jun;387(10037):2565-74

Pittsburgh Heart, Lung, Blood and Vascular Medicine Institute, Division of Pulmonary, Allergy and Critical Care Medicine, Pittsburgh, PA, USA; Department of Medicine, University of Pittsburgh, Pittsburgh, PA, USA. Electronic address:

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http://dx.doi.org/10.1016/S0140-6736(16)00647-4DOI Listing
June 2016

Peroxidase activation of cytoglobin by anionic phospholipids: Mechanisms and consequences.

Biochim Biophys Acta 2016 May 27;1861(5):391-401. Epub 2016 Feb 27.

Department of Environmental and Occupational Health, University of Pittsburgh, Pittsburgh, PA 15219, USA; Center for Free Radical and Antioxidant Health and Center for Medical Countermeasures against Radiation, University of Pittsburgh, Pittsburgh, PA 15219, USA; Department of Chemistry, University of Pittsburgh, Pittsburgh, PA 15219, USA; Department of Pharmacology and Chemical Biology, University of Pittsburgh, Pittsburgh, PA 15219, USA; Department of Radiation Oncology, University of Pittsburgh, Pittsburgh, PA 15219, USA. Electronic address:

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http://dx.doi.org/10.1016/j.bbalip.2016.02.022DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4821708PMC
May 2016

Crises in Sickle Cell Disease.

Chest 2016 Apr 28;149(4):1082-93. Epub 2015 Dec 28.

Pittsburgh Heart, Lung, and Blood Vascular Medicine Institute, University of Pittsburgh, Pittsburgh, PA; Division of Pulmonary, Allergy, and Critical Care Medicine, University of Pittsburgh, Pittsburgh, PA; Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA. Electronic address:

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http://dx.doi.org/10.1016/j.chest.2015.12.016DOI Listing
April 2016

Noninfectious and Nonneoplastic Conditions Associated with Human Immunodeficiency Virus Infection.

Semin Respir Crit Care Med 2016 Apr 14;37(2):289-302. Epub 2016 Mar 14.

Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania.

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http://dx.doi.org/10.1055/s-0036-1572560DOI Listing
April 2016

Elevated NT-pro-brain natriuretic peptide level is independently associated with all-cause mortality in HIV-infected women in the early and recent HAART eras in the Women's Interagency HIV Study cohort.

PLoS One 2015 26;10(3):e0123389. Epub 2015 Mar 26.

Division of Pulmonary, Allergy, and Critical Care Medicine, Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA, United States of America; Department of Immunology, University of Pittsburgh School of Medicine, Pittsburgh, PA, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0123389PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4374715PMC
March 2016

Sodium nitrite blocks the activity of aminoglycosides against Pseudomonas aeruginosa biofilms.

Antimicrob Agents Chemother 2015 23;59(6):3329-34. Epub 2015 Mar 23.

Department of Microbiology and Molecular Genetics, University of Pittsburgh, Pittsburgh, Pennsylvania, USA

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http://dx.doi.org/10.1128/AAC.00546-15DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4432197PMC
February 2016

Increased consumption and vasodilatory effect of nitrite during exercise.

Am J Physiol Lung Cell Mol Physiol 2016 Feb 18;310(4):L354-64. Epub 2015 Dec 18.

Vascular Medicine Branch, National Heart, Lung, and Blood Institute, Bethesda, Maryland;

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http://dx.doi.org/10.1152/ajplung.00081.2015DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4754905PMC
February 2016

SIRT3-AMP-Activated Protein Kinase Activation by Nitrite and Metformin Improves Hyperglycemia and Normalizes Pulmonary Hypertension Associated With Heart Failure With Preserved Ejection Fraction.

Circulation 2016 Feb 26;133(8):717-31. Epub 2016 Jan 26.

From Pittsburgh Heart, Lung, Blood and Vascular Medicine Institute, University of Pittsburgh, Pittsburgh, PA (Y.-C.L., D.M.T., K.S.H., R.R.V., D.A.G., E.A.G., S.P.T., A.L.M., M.T.G.); Division of Endocrinology and Metabolism, University of Pittsburgh, Pittsburgh, PA (J.J.D.); Division of Pediatric Endocrinology, Metabolism and Diabetes Mellitus, University of Pittsburgh, Pittsburgh, PA (K.S.H.); Center for Biologic Imaging, University of Pittsburgh, Pittsburgh, PA (C.M.St.C.); Diabetes, Obesity and Metabolism Institute, Icahn School of Medicine at Mount Sinai, New York, NY (A.G.-O.); and Division of Pulmonary, Allergy and Critical Care Medicine, University of Pittsburgh, Pittsburgh, PA (E.A.G., S.P.T., A.L.M., M.T.G.).

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http://dx.doi.org/10.1161/CIRCULATIONAHA.115.018935DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4766041PMC
February 2016

Shining a Light on the Dark Side.

Ann Intern Med 2016 Jan;164(1):69

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http://dx.doi.org/10.7326/L16-0013DOI Listing
January 2016

Nitrite and nitrate-dependent generation of anti-inflammatory fatty acid nitroalkenes.

Free Radic Biol Med 2015 Dec 16;89:333-41. Epub 2015 Sep 16.

Department of Pharmacology and Chemical Biology, University of Pittsburgh, Pittsburgh, PA 15261, USA; Pittsburgh Heart, Lung, Blood and Vascular Medicine Institute, University of Pittsburgh, Pittsburgh PA, 15261, USA. Electronic address:

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http://dx.doi.org/10.1016/j.freeradbiomed.2015.07.149DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4684780PMC
December 2015

Effects of Aged Stored Autologous Red Blood Cells on Human Endothelial Function.

Am J Respir Crit Care Med 2015 Nov;192(10):1223-33

1 Division of Pulmonary Allergy and Critical Care Medicine, University of Pittsburgh and University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania.

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http://dx.doi.org/10.1164/rccm.201501-0145OCDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4731619PMC
November 2015

Shining a Light on Carbon Monoxide Poisoning.

Am J Respir Crit Care Med 2015 Nov;192(10):1145-7

1 Pittsburgh Heart, Lung, Blood and Vascular Medicine Institute University of Pittsburgh Pittsburgh, Pennsylvania and.

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http://dx.doi.org/10.1164/rccm.201508-1579EDDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4731625PMC
November 2015

Genetic variants and cell-free hemoglobin processing in sickle cell nephropathy.

Haematologica 2015 Oct 23;100(10):1275-84. Epub 2015 Jul 23.

Division of Hematology & Oncology, Department of Medicine, Comprehensive Sickle Cell Center, University of Illinois at Chicago, IL

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http://dx.doi.org/10.3324/haematol.2015.124875DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4591759PMC
October 2015

Strategies to increase nitric oxide signalling in cardiovascular disease.

Nat Rev Drug Discov 2015 Sep 7;14(9):623-41. Epub 2015 Aug 7.

Department of Physiology and Pharmacology, Karolinska Institute, SE-171 77 Stockholm, Sweden.

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http://www.nature.com/articles/nrd4623
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http://dx.doi.org/10.1038/nrd4623DOI Listing
September 2015

Update in Pulmonary Vascular Diseases 2014.

Am J Respir Crit Care Med 2015 Sep;192(5):544-50

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4595695PMC
September 2015

Revisiting the hyperhemolysis paradigm.

Authors:
Mark T Gladwin

Blood 2015 Aug;126(6):695-6

UNIVERSITY OF PITTSBURGH.

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http://dx.doi.org/10.1182/blood-2015-06-649491DOI Listing
August 2015

Inorganic nitrite improves components of the metabolic syndrome independent of weight change in a murine model of obesity and insulin resistance.

J Physiol 2015 Jul 25;593(14):3135-45. Epub 2015 Jun 25.

Division of Pulmonary, Allergy and Critical Care Medicine, University of Pittsburgh Medical Center, University of Pittsburgh, 3459 Fifth Avenue 628 NW, Pittsburgh, PA, 15213, USA.

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http://dx.doi.org/10.1113/JP270386DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4532532PMC
July 2015