Mark Shackleton

Mark Shackleton

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Mark Shackleton

Mark Shackleton

Publications by authors named "Mark Shackleton"

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An update on adjuvant systemic therapies in melanoma.

Melanoma Manag 2019 Nov 13;6(3):MMT28. Epub 2019 Nov 13.

Department of Medical Oncology, The Alfred Hospital, Melbourne 3004, Australia.

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http://dx.doi.org/10.2217/mmt-2019-0009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6891936PMC
November 2019

Bevacizumab as a steroid-sparing agent during immunotherapy for melanoma brain metastases: A case series.

Health Sci Rep 2019 Mar 1;2(3):e115. Epub 2019 Feb 1.

Department of Cancer Medicine, Melbourne Peter MacCallum Cancer Centre Australia.

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http://dx.doi.org/10.1002/hsr2.115DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6427059PMC
March 2019

Personalised surveillance after treatment for high-risk cancer.

Oncotarget 2019 Jan 22;10(7):694-695. Epub 2019 Jan 22.

Mark Shackleton: Cancer Treatment and Development Laboratory, Central Clinical School, Monash University, Victoria, Australia; Department of Oncology, Alfred Health, Victoria, Australia.

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http://www.oncotarget.com/fulltext/26619
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http://dx.doi.org/10.18632/oncotarget.26619DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6366832PMC
January 2019

Calcium-Dependent Enhancement by Extracellular Acidity of the Cytotoxicity of Mitochondrial Inhibitors against Melanoma.

Mol Cancer Ther 2017 05 21;16(5):936-947. Epub 2017 Feb 21.

Department of Regenerative Dermatology, Graduate School of Medicine, Osaka University, Osaka, Japan.

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http://dx.doi.org/10.1158/1535-7163.MCT-15-0235DOI Listing
May 2017

CD271 Expression on Patient Melanoma Cells Is Unstable and Unlinked to Tumorigenicity.

Cancer Res 2016 07 20;76(13):3965-77. Epub 2016 Jun 20.

Cancer Development and Treatment Laboratory, Peter MacCallum Cancer Centre, East Melbourne, Australia. Sir Peter MacCallum Department of Pathology, University of Melbourne, Parkville, Australia. Sir Peter MacCallum Department of Oncology, University of Melbourne, Parkville, Australia. Department of Cancer Medicine, Peter MacCallum Cancer Centre, East Melbourne, Australia.

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http://dx.doi.org/10.1158/0008-5472.CAN-15-2377DOI Listing
July 2016

Tumour procurement, DNA extraction, coverage analysis and optimisation of mutation-detection algorithms for human melanoma genomes.

Pathology 2015 Dec;47(7):683-93

1Melanoma Institute Australia, North Sydney, NSW 2Sydney Medical School, The University of Sydney, Camperdown, NSW 3Immunogenomics Laboratory, Australian National University, Canberra, ACT 4Oncogenomics Laboratory, QIMR Berghofer Medical Research Institute, Herston, Brisbane, Qld 5Centre for Cancer Research, The University of Sydney at Westmead Millennium Institute, Westmead, NSW 6Bioplatforms Australia, Macquarie University, North Ryde, NSW 7Ludwig Institute for Cancer Research, Olivia Newton-John Cancer and Wellness Centre, Austin Health, Heidelberg, Vic 8The Cancer Development and Treatment Laboratory, Peter MacCallum Cancer Centre and Sir Peter MacCallum Department of Oncology, The University of Melbourne, Vic 9Departments of Melanoma and Surgical Oncology 10Tissue Pathology and Diagnostic Oncology, Royal Prince Alfred Hospital, Camperdown, NSW, Australia; these authors contributed equally.

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http://dx.doi.org/10.1097/PAT.0000000000000324DOI Listing
December 2015

The transcription cofactor c-JUN mediates phenotype switching and BRAF inhibitor resistance in melanoma.

Sci Signal 2015 Aug 18;8(390):ra82. Epub 2015 Aug 18.

Molecular Oncology Laboratory, Peter MacCallum Cancer Centre, St. Andrew's Place, East Melbourne, Victoria 3002, Australia. Oncogenic Signalling and Growth Control Program, Peter MacCallum Cancer Centre, East Melbourne, Victoria 3002, Australia. Sir Peter MacCallum Department of Oncology, Faculty of Medicine, Dentistry and Health Sciences, University of Melbourne, Victoria 3010, Australia. Cancer Therapeutics Program, Peter MacCallum Cancer Centre, East Melbourne, Victoria 3002, Australia. Department of Pathology, Faculty of Medicine, Dentistry and Health Sciences, University of Melbourne, Victoria 3010, Australia.

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http://dx.doi.org/10.1126/scisignal.aab1111DOI Listing
August 2015

Whole-genome characterization of chemoresistant ovarian cancer.

Nature 2015 May;521(7553):489-94

1] Peter MacCallum Cancer Centre, East Melbourne, Victoria 3002, Australia [2] Department of Pathology, University of Melbourne, Parkville, Victoria 3052, Australia [3] Sir Peter MacCallum Cancer Centre Department of Oncology, University of Melbourne, Parkville, Victoria 3052, Australia [4] Ovarian Cancer Action Research Centre, Department of Surgery and Cancer, Imperial College London, London W12 0HS, UK [5] Department of Biochemistry and Molecular Biology, University of Melbourne, Parkville, Victoria 3052, Australia.

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http://dx.doi.org/10.1038/nature14410DOI Listing
May 2015

Current management of advanced melanoma: a transformed landscape.

ANZ J Surg 2014 Sep 20;84(9):612-7. Epub 2014 May 20.

Division of Cancer Surgery, Peter MacCallum Cancer Centre, East Melbourne, Victoria, Australia; Department of Surgery, University of Melbourne, Parkville, Victoria, Australia.

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http://dx.doi.org/10.1111/ans.12673DOI Listing
September 2014

Socrates: identification of genomic rearrangements in tumour genomes by re-aligning soft clipped reads.

Bioinformatics 2014 04 2;30(8):1064-1072. Epub 2014 Jan 2.

Bioinformatics Division, The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria 3052, Department of Medical Biology, University of Melbourne, Victoria 3010, Melanoma Research Laboratory, Peter MacCallum Cancer Centre, East Melbourne, Victoria 3002, Department of Pathology, The University of Melbourne, Victoria 3010, NICTA Victoria Laboratory, The University of Melbourne, Victoria 3010, Department of Computing and Information Systems, University of Melbourne, Victoria 3010, Cancer Therapeutics Program, Peter MacCallum Cancer Centre, East Melbourne, Victoria 3002, Sir Peter MacCallum Department of Oncology, The University of Melbourne, Victoria 3010, Department of Mathematics and Statistics, The University of Melbourne, Victoria 3010 and Bioinformatics and Cancer Genomics Laboratory, Peter MacCallum Cancer Centre, East Melbourne, Victoria 3002, Australia Bioinformatics Division, The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria 3052, Department of Medical Biology, University of Melbourne, Victoria 3010, Melanoma Research Laboratory, Peter MacCallum Cancer Centre, East Melbourne, Victoria 3002, Department of Pathology, The University of Melbourne, Victoria 3010, NICTA Victoria Laboratory, The University of Melbourne, Victoria 3010, Department of Computing and Information Systems, University of Melbourne, Victoria 3010, Cancer Therapeutics Program, Peter MacCallum Cancer Centre, East Melbourne, Victoria 3002, Sir Peter MacCallum Department of Oncology, The University of Melbourne, Victoria 3010, Department of Mathematics and Statistics, The University of Melbourne, Victoria 3010 and Bioinformatics and Cancer Genomics Laboratory, Peter MacCallum Cancer Centre, East Melbourne, Victoria 3002, Australia Bioinformatics Division, The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria 3052, Department of Medical Biology, University of Melbourne, Victoria 3010, Melanoma Research Laboratory, Peter MacCallum Cancer Centre, East Melbourne, Victoria 3002, Department of Pathology, The University of Melbourne, Victoria 3010, NICTA Victoria Laboratory, The University of Melbourne, Victoria 3010, Department of Computing and Information Systems, University of Melbourne, Victoria 3010, Cancer Therapeutics Program, Peter MacCallum Cancer Centre, East Melbourne, Victoria 3002, Sir Peter MacCallum Department of Oncology, The University of Melbourne, Victoria 3010, Department of Mathematics and Statistics, The University of Melbourne, Victoria 3010 and Bioinformatics and Cancer Genomics Laboratory, Peter MacCallum Cancer Centre, East Melbourne, Victoria 3002, Australia Bioinformatics Division, The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria 3052, Department of Medical Biology, University of Melbourne, Victoria 3010, Melanoma Research Laboratory, Peter MacCallum Cancer Centre, East Melbourne, Victoria 3002, Department of Pathology, The University of Melbourne, Victoria 3010, NICTA Victoria Laboratory, The University of Melbourne, Victoria 3010, Department of Computing and Information Systems, University of Melbourne, Victoria 3010, Cancer Therapeutics Program, Peter MacCallum Cancer Centre, East Melbourne, Victoria 3002, Sir Peter MacCallum Department of Oncology, The University of Melbourne, Victoria 3010, Department of Mathematics and Statistics, The University of Melbourne, Victoria 3010 and Bioinformatics and Cancer Genomics Laboratory, Peter MacCallum Cancer Centre, East Melbourne, Victoria 3002, Australia.

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http://dx.doi.org/10.1093/bioinformatics/btt767DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3982158PMC
April 2014

Evaluating two infiltration gallery designs for managed aquifer recharge using secondary treated wastewater.

J Environ Manage 2013 Mar 4;117:115-20. Epub 2013 Feb 4.

CSIRO Water for a Healthy Country Flagship, CSIRO Centre for Environment and Life Sciences, Private Bag No. 5, PO Wembley, Western Australia 6913, Australia.

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http://dx.doi.org/10.1016/j.jenvman.2012.12.018DOI Listing
March 2013

Human melanoma metastasis in NSG mice correlates with clinical outcome in patients.

Sci Transl Med 2012 Nov;4(159):159ra149

Howard Hughes Medical Institute, Life Sciences Institute, Department of Internal Medicine, and Center for Stem Cell Biology, University of Michigan, Ann Arbor, MI 48109-2216, USA.

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http://dx.doi.org/10.1126/scitranslmed.3004599DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4501487PMC
November 2012

MDM4 is a key therapeutic target in cutaneous melanoma.

Nat Med 2012 Aug 22;18(8):1239-47. Epub 2012 Jul 22.

Center for the Biology of Disease, Laboratory for Molecular Cancer Biology, Vlaams Instituut voor Biotechnologie (VIB), Leuven, Belgium; Center for Human Genetics, Katholieke Universiteit (KU) Leuven, Leuven, Belgium.

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http://dx.doi.org/10.1038/nm.2863DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3744207PMC
August 2012

Pulling RANK: are some melanoma cells more malignant than others?

Authors:
Mark Shackleton

J Invest Dermatol 2011 Apr;131(4):814-6

Melanoma Research Laboratory and Department of Hematology and Medical Oncology, Peter MacCallum Cancer Centre, East Melbourne, Australia.

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http://linkinghub.elsevier.com/retrieve/pii/S0022202X1535211
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http://dx.doi.org/10.1038/jid.2011.18DOI Listing
April 2011

HIV-1 utilizes the CXCR4 chemokine receptor to infect multipotent hematopoietic stem and progenitor cells.

Cell Host Microbe 2011 Mar;9(3):223-234

Graduate Program in Cellular and Molecular Biology, University of Michigan, Ann Arbor, MI 48109, USA; Medical Scientist Training Program, University of Michigan, Ann Arbor, MI 48109, USA; Department of Microbiology and Immunology, University of Michigan, Ann Arbor, MI 48109, USA; Department of Internal Medicine, University of Michigan, Ann Arbor, MI 48109, USA. Electronic address:

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http://dx.doi.org/10.1016/j.chom.2011.02.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3102232PMC
March 2011

Progress in understanding melanoma propagation.

Mol Oncol 2010 Oct 23;4(5):451-7. Epub 2010 Jun 23.

Melanoma Research Laboratory and Department of Hematology and Medical Oncology, Peter MacCallum Cancer Centre, East Melbourne, Australia.

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http://dx.doi.org/10.1016/j.molonc.2010.06.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3033805PMC
October 2010

Melanoma stem cells--are there devils in the detail?

Authors:
Mark Shackleton

Pigment Cell Melanoma Res 2010 Oct 5;23(5):693-4. Epub 2010 Aug 5.

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http://dx.doi.org/10.1111/j.1755-148X.2010.00750.xDOI Listing
October 2010

Moving targets that drive cancer progression.

Authors:
Mark Shackleton

N Engl J Med 2010 Aug;363(9):885-6

Melanoma Research Laboratory and Department of Hematology and Medical Oncology, Peter MacCallum Cancer Centre, East Melbourne, Australia.

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http://www.nejm.org/doi/abs/10.1056/NEJMcibr1006328
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http://dx.doi.org/10.1056/NEJMcibr1006328DOI Listing
August 2010

Normal stem cells and cancer stem cells: similar and different.

Authors:
Mark Shackleton

Semin Cancer Biol 2010 Apr 29;20(2):85-92. Epub 2010 Apr 29.

Melanoma Research Laboratory and Department of Hematology and Medical Oncology, Peter MacCallum Cancer Centre, East Melbourne 3002, Australia.

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http://linkinghub.elsevier.com/retrieve/pii/S1044579X1000023
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http://dx.doi.org/10.1016/j.semcancer.2010.04.002DOI Listing
April 2010

Use of static Quantitative Microbial Risk Assessment to determine pathogen risks in an unconfined carbonate aquifer used for Managed Aquifer Recharge.

Water Res 2010 Feb 27;44(4):1038-49. Epub 2009 Aug 27.

CSIRO Water for a Healthy Country, Queensland Bioscience Precinct, 306 Carmody Road, St Lucia, Brisbane, QLD 4067, Australia.

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http://linkinghub.elsevier.com/retrieve/pii/S004313540900545
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http://dx.doi.org/10.1016/j.watres.2009.08.028DOI Listing
February 2010

Heterogeneity in cancer: cancer stem cells versus clonal evolution.

Cell 2009 Sep;138(5):822-9

Howard Hughes Medical Institute, Life Sciences Institute, Center for Stem Cell Biology, University of Michigan, Ann Arbor, MI 48109, USA.

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https://linkinghub.elsevier.com/retrieve/pii/S00928674090103
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http://dx.doi.org/10.1016/j.cell.2009.08.017DOI Listing
September 2009

Impaired lactation in mice expressing dominant-negative FADD in mammary epithelium.

Dev Dyn 2009 Apr;238(4):1010-6

Molecular Genetics of Cancer Division, The Walter and Eliza Hall Institute of Medical Research, Parkville, VIC, Australia.

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http://dx.doi.org/10.1002/dvdy.21917DOI Listing
April 2009

Efficient tumour formation by single human melanoma cells.

Nature 2008 Dec;456(7222):593-8

Howard Hughes Medical Institute, Life Sciences Institute, Department of Internal Medicine, and Center for Stem Cell Biology, University of Michigan, Ann Arbor, Michigan 48109-2216, USA.

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http://dx.doi.org/10.1038/nature07567DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2597380PMC
December 2008

The emerging picture of the mouse mammary stem cell.

Stem Cell Rev 2007 Jun;3(2):114-23

Victorian Breast Cancer Research Consortium Laboratory, The Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, VIC 3050, Australia.

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http://link.springer.com/content/pdf/10.1007/s12015-007-0018
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http://dx.doi.org/10.1007/s12015-007-0018-2DOI Listing
June 2007

Gata-3 is an essential regulator of mammary-gland morphogenesis and luminal-cell differentiation.

Nat Cell Biol 2007 Feb 24;9(2):201-9. Epub 2006 Dec 24.

VBCRC Laboratory, The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria 3050, Australia.

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http://dx.doi.org/10.1038/ncb1530DOI Listing
February 2007

Self-organized service orchestration through collective differentiation.

IEEE Trans Syst Man Cybern B Cybern 2006 Dec;36(6):1237-46

Pervasive ICT Research Centre, British Telecommunications plc., London EC1A 7AJ, UK.

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http://dx.doi.org/10.1109/tsmcb.2006.873214DOI Listing
December 2006

Steroid hormone receptor status of mouse mammary stem cells.

J Natl Cancer Inst 2006 Jul;98(14):1011-4

VBCRC Laboratory, The Walter and Eliza Hall Institute of Medical Research, Melbourne, Victoria, Australia.

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http://dx.doi.org/10.1093/jnci/djj267DOI Listing
July 2006

Purification and unique properties of mammary epithelial stem cells.

Nature 2006 Feb 4;439(7079):993-7. Epub 2006 Jan 4.

Terry Fox Laboratory, British Columbia Cancer Agency, Vancouver V5Z 1L3, British Columbia, Canada.

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http://dx.doi.org/10.1038/nature04496DOI Listing
February 2006

Generation of a functional mammary gland from a single stem cell.

Nature 2006 Jan;439(7072):84-8

The Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, Victoria 3050, Australia.

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http://dx.doi.org/10.1038/nature04372DOI Listing
January 2006

Biofumigation: environmental impacts on the biological activity of diverse pure and plant-derived isothiocyanates.

Pest Manag Sci 2005 Nov;61(11):1043-51

CSIRO Entomology, Wembley, Australia.

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http://doi.wiley.com/10.1002/ps.1086
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http://dx.doi.org/10.1002/ps.1086DOI Listing
November 2005

Loss of the LIM domain protein Lmo4 in the mammary gland during pregnancy impedes lobuloalveolar development.

Oncogene 2005 Jul;24(30):4820-8

The Walter and Eliza Hall Institute of Medical Research and Bone Marrow Research Laboratories, 1G Royal Parade, Parkville, VIC 3050, Australia.

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http://dx.doi.org/10.1038/sj.onc.1208638DOI Listing
July 2005

The impact of imiquimod, a Toll-like receptor-7 ligand (TLR7L), on the immunogenicity of melanoma peptide vaccination with adjuvant Flt3 ligand.

Cancer Immun 2004 Sep 23;4. Epub 2004 Sep 23.

Cancer Vaccine Laboratory, Ludwig Institute for Cancer Research, Austin Health, Studley Road, Heidelberg, 3084, Australia.

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September 2004