Publications by authors named "Mark S Silverberg"

100Publications

What Constitutes Frailty In Inflammatory Bowel Disease?

Gastroenterology 2020 Aug 12. Epub 2020 Aug 12.

Division of Gastroenterology, University of Toronto, Toronto, Ontario, Canada; Mount Sinai Hospital Inflammatory Bowel Disease Centre, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1053/j.gastro.2020.07.060DOI Listing
August 2020

Persistent Diarrhea in Patients With Crohn's Disease After Mucosal Healing Is Associated With Lower Diversity of the Intestinal Microbiome and Increased Dysbiosis.

Clin Gastroenterol Hepatol 2020 Mar 24. Epub 2020 Mar 24.

Division of Gastroenterology, Mount Sinai Hospital, University of Toronto, Toronto, Ontario, Canada; Zane Cohen Centre for Digestive Diseases, Lunenfeld-Tanenbaum Research Institute, Sinai Health System, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1016/j.cgh.2020.03.044DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7511440PMC
March 2020

Histological Markers of Clinical Relapse in Endoscopically Quiescent Ulcerative Colitis.

Inflamm Bowel Dis 2019 Dec 28. Epub 2019 Dec 28.

Zane Cohen Centre for Digestive Diseases, Mount Sinai Hospital, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1093/ibd/izz308DOI Listing
December 2019

Colonic Vascular Prominence From Superior Mesenteric Vein Occlusion.

ACG Case Rep J 2019 Jan 13;6(1):e00012. Epub 2019 Feb 13.

Mount Sinai Hospital, Sinai Health System, Toronto, ON.

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http://dx.doi.org/10.14309/crj.0000000000000012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6493693PMC
January 2019

Preoperative exposure to anti-tumor necrosis factor therapy in ulcerative colitis patients undergoing ileal pouch-anal anastomosis (IPAA) is not associated with histological fibrosis: A case control study.

Int J Surg 2019 May 26;65:80-85. Epub 2019 Mar 26.

Mount Sinai Hospital, Zane Cohen Centre for Digestive Diseases, Division of Gastroenterology, Department of Medicine, University of Toronto, Toronto, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.ijsu.2019.03.016DOI Listing
May 2019

The Unsolved Link of Genetic Markers and Crohn's Disease Progression: A North American Cohort Experience.

Inflamm Bowel Dis 2019 08;25(9):1541-1549

Zane Cohen Centre for Digestive Diseases, Mount Sinai Hospital IBD Group, Division of Gastroenterology, Department of Medicine, University of Toronto, Toronto, Canada.

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http://dx.doi.org/10.1093/ibd/izz016DOI Listing
August 2019

Fecal calprotectin correlates with active colonic inflammatory bowel disease but not with small intestinal Crohn's disease activity.

JGH Open 2018 Oct 17;2(5):201-206. Epub 2018 Jul 17.

Division of Gastroenterology, Department of Medicine, Zane Cohen Center, Mount Sinai Hospital University of Toronto Toronto Ontario Canada.

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http://dx.doi.org/10.1002/jgh3.12068DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6207015PMC
October 2018

The Prevalence and Clinical Associations of Subclinical Sacroiliitis in Inflammatory Bowel Disease.

Inflamm Bowel Dis 2019 05;25(6):1066-1071

Zane Cohen Center for Digestive Disease, Division of Gastroenterology, Mount Sinai Hospital, University of Toronto, Toronto, ON, Canada.

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https://academic.oup.com/ibdjournal/advance-article/doi/10.1
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http://dx.doi.org/10.1093/ibd/izy339DOI Listing
May 2019

Stricturing and Fistulizing Crohn's Disease Is Associated with Anti-tumor Necrosis Factor-Induced Psoriasis in Patients with Inflammatory Bowel Disease.

Dig Dis Sci 2018 09 8;63(9):2430-2438. Epub 2018 May 8.

Division of Gastroenterology, Department of Medicine, Mount Sinai Hospital IBD Centre, University of Toronto, 441-600 University Avenue, Toronto, ON, M5G 1X5, Canada.

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http://dx.doi.org/10.1007/s10620-018-5096-2DOI Listing
September 2018

Higher Infliximab Levels Are Not Associated With an Increase in Adverse Events in Inflammatory Bowel Disease.

Inflamm Bowel Dis 2018 07;24(8):1808-1814

Division of Gastroenterology, Department of Medicine, University of Toronto, Toronto, Canada.

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https://academic.oup.com/ibdjournal/article/24/8/1808/498551
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http://dx.doi.org/10.1093/ibd/izy066DOI Listing
July 2018

Reliability among central readers in the evaluation of endoscopic disease activity in pouchitis.

Gastrointest Endosc 2018 08 13;88(2):360-369.e2. Epub 2018 Apr 13.

Robarts Clinical Trials Inc, London, Ontario, Canada; Department of Epidemiology and Biostatistics, University of Western Ontario, London, Ontario, Canada; Department of Medicine, University of Western Ontario, London, Ontario, Canada.

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http://dx.doi.org/10.1016/j.gie.2018.04.2330DOI Listing
August 2018

Accelerated Clearance of Infliximab is Associated With Treatment Failure in Patients With Corticosteroid-Refractory Acute Ulcerative Colitis.

J Crohns Colitis 2018 May;12(6):662-669

Division of Gastroenterology, Mount Sinai Hospital Inflammatory Bowel Disease Centre, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1093/ecco-jcc/jjy028DOI Listing
May 2018

Inflammatory Bowel Disease-Gastroenterology Diamond Jubilee Review.

Gastroenterology 2018 05 15;154(6):1555-1558. Epub 2018 Mar 15.

University of California, San Francisco, California, and Mount Sinai Hospital Inflammatory Bowel Disease Centre, University of Toronto, Toronto, Canada.

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http://dx.doi.org/10.1053/j.gastro.2017.12.025DOI Listing
May 2018

The Unfinished Symphony: Golimumab Therapy for Anti-Tumour Necrosis Factor Refractory Crohn's Disease.

J Crohns Colitis 2018 Mar;12(4):458-464

Zane Cohen Centre for Digestive Diseases, Mount Sinai Hospital IBD Group, Toronto, Ontario, Canada; Division of Gastroenterology, Department of Medicine, University of Toronto, Toronto, Canada.

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http://dx.doi.org/10.1093/ecco-jcc/jjx176DOI Listing
March 2018

Genetic association analysis identifies variants associated with disease progression in primary sclerosing cholangitis.

Gut 2018 08 4;67(8):1517-1524. Epub 2017 Aug 4.

Department of Gastroenterology and Hepatology, University of Groningen and University Medical Centre Groningen, Groningen, The Netherlands.

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http://dx.doi.org/10.1136/gutjnl-2016-313598DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5797498PMC
August 2018

Prevalence of Sacroiliitis in Inflammatory Bowel Disease Using a Standardized Computed Tomography Scoring System.

Arthritis Care Res (Hoboken) 2018 05 2;70(5):807-810. Epub 2018 Apr 2.

Toronto Western Hospital and University of Toronto, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1002/acr.23323DOI Listing
May 2018

The NOD2-Smoking Interaction in Crohn's Disease is likely Specific to the 1007fs Mutation and may be Explained by Age at Diagnosis: A Meta-Analysis and Case-Only Study.

EBioMedicine 2017 Jul 16;21:188-196. Epub 2017 Jun 16.

Department of Medicine, University of Calgary, Calgary, Alberta, Canada; Department of Community Health Sciences, University of Calgary, Calgary, Alberta, Canada; O'Brien Institute for Public Health, University of Calgary, Calgary, Alberta, Canada; Faculty of Veterinary Medicine, University of Calgary, Calgary, Alberta, Canada; (i)Alberta Inflammatory Bowel Disease Consortium, University of Calgary, Calgary, Alberta, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.ebiom.2017.06.012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5514403PMC
July 2017

Therapeutic Drug Monitoring to Guide Infliximab Dose Adjustment is Associated with Better Endoscopic Outcomes than Clinical Decision Making Alone in Active Inflammatory Bowel Disease.

Inflamm Bowel Dis 2017 07;23(7):1202-1209

Division of Gastroenterology, Zane Cohen Centre for Digestive Diseases, Division of Gastroenterology, Mount Sinai Hospital, University of Toronto, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1097/MIB.0000000000001126DOI Listing
July 2017

Development of the Harvey-Bradshaw Index-pro (HBI-PRO) Score to Assess Endoscopic Disease Activity in Crohn's Disease.

J Crohns Colitis 2017 May;11(5):543-548

Mount Sinai Hospital, Zane Cohen Centre for Digestive Diseases, Division of Gastroenterology, Department of Medicine, University of Toronto, Toronto, Canada.

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http://dx.doi.org/10.1093/ecco-jcc/jjw200DOI Listing
May 2017

Public versus Private Drug Insurance and Outcomes of Patients Requiring Biologic Therapies for Inflammatory Bowel Disease.

Can J Gastroenterol Hepatol 2017 23;2017:7365937. Epub 2017 Jan 23.

Institute of Health Policy, Management and Evaluation, University of Toronto, Toronto, ON, Canada; Mount Sinai Hospital Centre for Inflammatory Bowel Disease, University of Toronto, Toronto, ON, Canada; Division of Gastroenterology, Department of Medicine, University of Toronto, Toronto, ON, Canada.

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http://dx.doi.org/10.1155/2017/7365937DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5292380PMC
March 2017

Brief Report: Functional Interaction of Endoplasmic Reticulum Aminopeptidase 2 and HLA-B27 Activates the Unfolded Protein Response.

Arthritis Rheumatol 2017 05;69(5):1009-1015

Toronto Western Research Institute, University of Toronto, and University Health Network, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1002/art.40033DOI Listing
May 2017

Genome-Wide Association Study Identifies African-Specific Susceptibility Loci in African Americans With Inflammatory Bowel Disease.

Gastroenterology 2017 01 28;152(1):206-217.e2. Epub 2016 Sep 28.

Department of Pediatrics, Emory University School of Medicine, Atlanta, Georgia; Department of Human Genetics, Emory University School of Medicine, Atlanta, Georgia. Electronic address:

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http://dx.doi.org/10.1053/j.gastro.2016.09.032DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5164948PMC
January 2017

Preoperative Anti-tumor Necrosis Factor Therapy in Patients with Ulcerative Colitis Is Not Associated with an Increased Risk of Infectious and Noninfectious Complications After Ileal Pouch-anal Anastomosis.

Inflamm Bowel Dis 2016 10;22(10):2442-7

*Zane Cohen Centre for Digestive Diseases, Mount Sinai Hospital, Division of Gastroenterology, Department of Medicine, University of Toronto, Toronto, Ontario, Canada; †Institute of Gastroenterology and Liver Diseases, Emek Medical Center, Afula, Israel; ‡Zane Cohen Centre for Digestive Diseases, Mount Sinai Hospital, Toronto, Ontario, Canada; §Zane Cohen Centre for Digestive Diseases, Mount Sinai Hospital, Division of General Surgery, University of Toronto, Toronto, Ontario, Canada; and ‖Mount Sinai Hospital, Division of General Surgery, University of Toronto, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1097/MIB.0000000000000919DOI Listing
October 2016

Genetic Predictors of Benign Course of Ulcerative Colitis-A North American Inflammatory Bowel Disease Genetics Consortium Study.

Inflamm Bowel Dis 2016 10;22(10):2311-6

*Division of Gastroenterology, McGill University Health Center, Montreal, Quebec, Canada; †Montreal Heart Institute, Montreal, Quebec, Canada; ‡Université de Montréal, Montreal, Quebec, Canada; §Division of Gastroenterology, Mount Sinai Hospital, Toronto, Ontario, Canada; ‖Division of Gastroenterology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania; ¶Section of Digestive Diseases, Yale University, New Haven, Connecticut; **Division of Gastroenterology, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, New York; ††Division of Gastroenterology, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, New York; ‡‡Translational Genomics Group, F. Widjaja Inflammatory Bowel and Immunobiology Research Institute, Cedars-Sinai Medical Center, Los Angeles, California; §§Division of Gastroenterology, University of Chicago, Chicago, Illinois; and ‖‖Meyerhoff Inflammatory Bowel Diseases Center, Division of Gastroenterology, Johns Hopkins School of Medicine, Baltimore, Maryland.

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http://dx.doi.org/10.1097/MIB.0000000000000913DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5098421PMC
October 2016

A protein-truncating R179X variant in RNF186 confers protection against ulcerative colitis.

Nat Commun 2016 08 9;7:12342. Epub 2016 Aug 9.

Division of Gastroenterology, Hepatology and Nutrition, Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15261, USA.

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http://dx.doi.org/10.1038/ncomms12342DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4980482PMC
August 2016

A Frameshift in CSF2RB Predominant Among Ashkenazi Jews Increases Risk for Crohn's Disease and Reduces Monocyte Signaling via GM-CSF.

Gastroenterology 2016 10 1;151(4):710-723.e2. Epub 2016 Jul 1.

Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, New York; Division of Gastroenterology, Icahn School of Medicine at Mount Sinai, New York, New York; The Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, New York. Electronic address:

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http://dx.doi.org/10.1053/j.gastro.2016.06.045DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5037012PMC
October 2016

Use of Complementary and Alternative Medicine for Inflammatory Bowel Disease Is Associated with Worse Adherence to Conventional Therapy: The COMPLIANT Study.

Inflamm Bowel Dis 2016 06;22(6):1412-7

*Mount Sinai Hospital Centre for Inflammatory Bowel Disease, Department of Medicine, University of Toronto, Ontario, Canada; and †Institute of Health Policy, Management and Evaluation, University of Toronto, Toronto, Canada.

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http://dx.doi.org/10.1097/MIB.0000000000000773DOI Listing
June 2016

TNFRSF1B Is Associated with ANCA in IBD.

Inflamm Bowel Dis 2016 06;22(6):1346-52

*Department of Medicine, F. Widjaja Foundation Inflammatory Bowel and Immunobiology Research Institute, Cedars-Sinai Medical Center, Los Angeles, California; †Mount Sinai Hospital, Toronto, Ontario, Canada; ‡The Susan and Leonard Feinstein IBD Clinical Center, East New York, New York; and §Institute for Translational Genomics and Population Science, Los Angeles Biomedical Research Institute and Department of Pediatrics, Harbor-UCLA Medical Center, Torrance, California.

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http://dx.doi.org/10.1097/MIB.0000000000000771DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7288902PMC
June 2016

Intraepithelial lymphocytosis is a frequent finding in biopsies from ileal pouch-anal anastomoses.

Hum Pathol 2016 08 8;54:31-6. Epub 2016 Apr 8.

Department of Laboratory Medicine and Pathology, Mount Sinai Hospital, Toronto, ON, Canada M5G 1X5.

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http://dx.doi.org/10.1016/j.humpath.2016.03.007DOI Listing
August 2016

Microbiome Heterogeneity Characterizing Intestinal Tissue and Inflammatory Bowel Disease Phenotype.

Inflamm Bowel Dis 2016 Apr;22(4):807-16

*Zane Cohen Centre for Digestive Diseases, Mount Sinai Hospital, Toronto, ON, Canada; †Laboratory Medicine and Pathology, Mount Sinai Hospital, Toronto, ON, Canada; ‡Division of Gastroenterology, Department of Medicine, University of Toronto, Toronto, ON, Canada; and §Institute of Medical Science, University of Toronto, Toronto, ON, Canada.

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http://dx.doi.org/10.1097/MIB.0000000000000674DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4812575PMC
April 2016

Modified Two-stage Ileal Pouch-Anal Anastomosis Results in Lower Rate of Anastomotic Leak Compared with Traditional Two-stage Surgery for Ulcerative Colitis.

J Crohns Colitis 2016 Jul 7;10(7):766-72. Epub 2016 Mar 7.

Zane Cohen Centre for Digestive Disease, Mount Sinai Hospital, Toronto, ON, Canada, Division of General Surgery, University of Toronto, Toronto, ON, Canada.

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http://dx.doi.org/10.1093/ecco-jcc/jjw069DOI Listing
July 2016

Low Fecal Calprotectin Correlates with Histological Remission and Mucosal Healing in Ulcerative Colitis and Colonic Crohn's Disease.

Inflamm Bowel Dis 2016 Mar;22(3):623-30

*Mount Sinai Hospital, Zane Cohen Center, University of Toronto, Toronto, ON, Canada; †Pathology and Lab Medicine, Mount Sinai Hospital, Zane Cohen Center, University of Toronto, Toronto, ON, Canada; ‡Mount Sinai Hospital, Zane Cohen Center, Toronto, ON, Canada; §Mount Sinai Hospital, Zane Cohen Center, University of Toronto, Luenefeld-Tannenbaum Research Institute, Toronto, ON, Canada; ‖University of Leuven, Leuven, Belgium; and #Institute of Gastroenterology and Liver Diseases, Ha'Emek Medical Center, Afula, Israel.

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http://dx.doi.org/10.1097/MIB.0000000000000652DOI Listing
March 2016

IBD Genetic Risk Profile in Healthy First-Degree Relatives of Crohn's Disease Patients.

J Crohns Colitis 2016 Feb 28;10(2):209-15. Epub 2015 Oct 28.

Zane Cohen Centre for Digestive Diseases, Mount Sinai Hospital, Toronto, ON, Canada Division of Gastroenterology, Department of Medicine, University of Toronto, Toronto, ON, Canada

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http://dx.doi.org/10.1093/ecco-jcc/jjv197DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5007582PMC
February 2016

Whole-exome Sequence Analysis Implicates Rare Il17REL Variants in Familial and Sporadic Inflammatory Bowel Disease.

Inflamm Bowel Dis 2016 Jan;22(1):20-7

*Department of Pediatrics and †Center for Research Informatics, The University of Chicago, Chicago, Illinois; ‡Northern Institute for Cancer Research, Newcastle University, Newcastle-upon-Tyne, United Kingdom; §Meyerhoff Inflammatory Bowel Disease Center, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland; ‖Department of Epidemiology, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, Maryland; ¶F. Widjaja Family Foundation Inflammatory Bowel and Immunobiology Research Institute, Cedars-Sinai Medical Center, Los Angeles, California; **Department of Genetics and Genomic Sciences and ††Zane Cohen Centre for Digestive Diseases, Department of Medicine, Mount Sinai Hospital, The University of Toronto, Toronto, Ontario, Canada; and ‡‡Department of Medicine, The Icahn School of Medicine at Mount Sinai, New York, New York.

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http://dx.doi.org/10.1097/MIB.0000000000000610DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4679526PMC
January 2016

Microbial Disruption of Autophagy Alters Expression of the RISC Component AGO2, a Critical Regulator of the miRNA Silencing Pathway.

Inflamm Bowel Dis 2015 Dec;21(12):2778-86

*Cell Biology Program, Hospital for Sick Children, Toronto, ON, Canada; †Departments of Pediatrics and Physiology, University of Toronto, Toronto, ON, Canada; ‡Zane Cohen Centre for Digestive Diseases, Mount Sinai Hospital IBD Group, Toronto, ON, Canada; and §Department of Immunology, University of Toronto, Toronto, ON, Canada.

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http://dx.doi.org/10.1097/MIB.0000000000000553DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4645954PMC
December 2015

Predictors of Outcome in Ulcerative Colitis.

Inflamm Bowel Dis 2015 Sep;21(9):2097-105

*Zane Cohen Centre for Digestive Diseases, Division of Gastroenterology, Mount Sinai Hospital, Toronto, ON, Canada; †Department of Gastroenterology, Rambam Health Care Campus, Haifa, Israel; ‡Campbell Family Mental Health Research Institute, Centre for Addiction and Mental Health, Neuroscience Research, Toronto, ON, Canada; §University of Toronto, Toronto, ON, Canada; ||Dalla Lana School of Public Health, University of Toronto, Toronto, ON, Canada; and ¶Department of Surgery, Mount Sinai Hospital, Toronto, ON, Canada.

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http://dx.doi.org/10.1097/MIB.0000000000000466DOI Listing
September 2015

Higher Rates of Dose Optimisation for Infliximab Responders in Ulcerative Colitis than in Crohn's disease.

J Crohns Colitis 2015 Oct 26;9(10):830-6. Epub 2015 Jun 26.

Zane Cohen Centre for Digestive Diseases, Mount Sinai Hospital IBD Group, Toronto, ON, Canada Division of Gastroenterology, Department of Medicine, University of Toronto, Toronto, ON, Canada

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http://dx.doi.org/10.1093/ecco-jcc/jjv115DOI Listing
October 2015

Extent of Early Clinical Response to Infliximab Predicts Long-term Treatment Success in Active Ulcerative Colitis.

Inflamm Bowel Dis 2015 Sep;21(9):2090-6

*The Ottawa Hospital IBD Centre, Department of Medicine, University of Ottawa and Ottawa Hospital Research Institute, Ottawa, ON, Canada; and †Mount Sinai Hospital IBD Centre, Department of Medicine, University of Toronto and Lunenfeld-Tanenbaum Research Institute, Toronto, ON, Canada.

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http://dx.doi.org/10.1097/MIB.0000000000000474DOI Listing
September 2015

Vaccination in inflammatory bowel disease patients: attitudes, knowledge, and uptake.

J Crohns Colitis 2015 Jun 23;9(6):439-44. Epub 2015 Apr 23.

Mount Sinai Hospital Centre for Inflammatory Bowel Disease, Toronto, ON, Canada Division of Gastroenterology, Department of Medicine, University of Toronto, Toronto, ON, Canada

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http://dx.doi.org/10.1093/ecco-jcc/jjv064DOI Listing
June 2015

Determinants of intestinal permeability in healthy first-degree relatives of individuals with Crohn's disease.

Inflamm Bowel Dis 2015 04;21(4):879-87

*Zane Cohen Centre for Digestive Diseases, Mount Sinai Hospital, Toronto, ON, Canada; †Division of Gastroenterology, Department of Medicine, University of Toronto, Toronto, ON, Canada; ‡Division of Gastroenterology, Department of Medicine, University of Alberta, Edmonton, AB, Canada; §Division of Gastroenterology, Department of Medicine, University of Calgary, Calgary, AB, Canada; ‖Dalla Lana School of Public Health, University of Toronto, Toronto, ON, Canada; ¶Department of Biology, University of Waterloo, Waterloo, ON, Canada; **Division of Gastroenterology, Hepatology and Nutrition, Department of Paediatrics, The Hospital for Sick Children, Toronto, ON, Canada; and ††The Hospital for Sick Children Research Institute, The Hospital for Sick Children, Toronto, ON, Canada.

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http://dx.doi.org/10.1097/MIB.0000000000000323DOI Listing
April 2015

Complex host genetics influence the microbiome in inflammatory bowel disease.

Genome Med 2014 2;6(12):107. Epub 2014 Dec 2.

Broad Institute of Harvard and MIT, Cambridge, Massachusetts 02142 USA ; Center for Computational and Integrative Biology, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02114 USA ; Division of Gastroenterology, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02114 USA.

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http://dx.doi.org/10.1186/s13073-014-0107-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4292994PMC
January 2015

Microbiome analysis - from technical advances to biological relevance.

F1000Prime Rep 2014 8;6:51. Epub 2014 Jul 8.

Zane Cohen Centre for Digestive Diseases, Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital 600 University Avenue, Room 437, Toronto, ON Canada, M5G 1X5 ; Institute of Medical Science, Department of Medicine University of Toronto, Toronto, ON Canada, M5S 1A8.

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http://dx.doi.org/10.12703/P6-51DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4108955PMC
September 2014

Distinctive histopathologic phenotype in resection specimens from patients with Crohn's disease receiving anti-TNF-α therapy.

Hum Pathol 2014 Sep 12;45(9):1928-35. Epub 2014 Jun 12.

Department of Laboratory Medicine and Pathology, Mount Sinai Hospital, Toronto, ON, Canada Joseph and Wolf Lebovic Health Complex 600 University Avenue Toronto, Ontario, Canada M5G 1X5; Zane Cohen Centre for Digestive Diseases, Toronto, ON, Canada 60 Murray Street Toronto, Ontario, Canada M5T 3L9.

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http://dx.doi.org/10.1016/j.humpath.2014.05.016DOI Listing
September 2014

Progression and Management of Duodenal Neoplasia in Familial Adenomatous Polyposis: A Cohort Study.

Ann Surg 2015 Jun;261(6):1138-44

*Department of Surgery, McMaster University, Hamilton, Ontario, Canada †Samuel Lunenfeld Research Institute, Mount Sinai Hospital, University of Toronto, Toronto, Ontario, Canada ‡Familial Gastrointestinal Cancer Registry, Mount Sinai Hospital, Toronto, Ontario, Canada §Toronto General Hospital, University of Toronto, Toronto, Ontario, Canada ¶Department of Pathology, Mount Sinai Hospital, University of Toronto, Toronto, Ontario, Canada; and ‖Division of Gastroenterology, St Michael's Hospital, University of Toronto, Toronto, Ontario, Canada.

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http://content.wkhealth.com/linkback/openurl?sid=WKPTLP:land
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http://dx.doi.org/10.1097/SLA.0000000000000734DOI Listing
June 2015

Variants in nicotinamide adenine dinucleotide phosphate oxidase complex components determine susceptibility to very early onset inflammatory bowel disease.

Gastroenterology 2014 Sep 12;147(3):680-689.e2. Epub 2014 Jun 12.

SickKids Inflammatory Bowel Disease Center and Cell Biology Program, Research Institute, The Hospital for Sick Children, Toronto, Ontario, Canada; Institute of Medical Science, University of Toronto, Toronto, Ontario, Canada; Division of Gastroenterology, Hepatology, and Nutrition, Department of Pediatrics, University of Toronto, The Hospital for Sick Children, Toronto, Ontario, Canada. Electronic address:

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http://dx.doi.org/10.1053/j.gastro.2014.06.005DOI Listing
September 2014

Downregulation of expression of xenobiotic efflux genes is associated with pelvic pouch inflammation in ulcerative colitis.

Inflamm Bowel Dis 2014 Jul;20(7):1157-64

*Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, ON, Canada; †Zane Cohen Centre for Digestive Diseases, Mount Sinai Hospital, Toronto, ON, Canada; and ‡Division of Gastroenterology, University of Toronto, Toronto, ON, Canada.

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http://dx.doi.org/10.1097/MIB.0000000000000078DOI Listing
July 2014

Analyzing the human microbiome: a "how to" guide for physicians.

Am J Gastroenterol 2014 Jul 22;109(7):983-93. Epub 2014 Apr 22.

1] Institute of Medical Science, University of Toronto, Toronto, Ontario, Canada [2] Zane Cohen Centre for Digestive Diseases, Mount Sinai Hospital Inflammatory Bowel Disease Group, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1038/ajg.2014.73DOI Listing
July 2014

Future directions in inflammatory bowel disease management.

J Crohns Colitis 2014 Aug 16;8(8):726-34. Epub 2014 Apr 16.

Division of Gastroenterology, Department of Internal Medicine, Catholic University of Leuven, Leuven, Belgium.

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http://dx.doi.org/10.1016/j.crohns.2014.02.025DOI Listing
August 2014

Attachment, childhood abuse, and IBD-related quality of life and disease activity outcomes.

Inflamm Bowel Dis 2014 May;20(5):909-15

*Zane Cohen Centre for Digestive Diseases, Mount Sinai Hospital, Joseph and Wolf Lebovic Health Complex, Toronto, Canada; †Department of Psychiatry, and ‡Division of Gastroenterology, Mount Sinai Hospital, Toronto, Canada; and §Department of Psychology, Ryerson University, Toronto, Canada.

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May 2014

Higher activity of the inducible nitric oxide synthase contributes to very early onset inflammatory bowel disease.

Clin Transl Gastroenterol 2014 Jan 16;5:e46. Epub 2014 Jan 16.

1] SickKids Inflammatory Bowel Disease Center and Cell Biology Program, Research Institute, Hospital for Sick Children, Toronto, Ontario, Canada [2] Institute of Medical Science, University of Toronto, Toronto, Ontario, Canada [3] Division of Gastroenterology, Hepatology, and Nutrition, Department of Pediatrics, University of Toronto, Hospital for Sick Children, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1038/ctg.2013.17DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3912315PMC
January 2014

Effect of inflammatory bowel disease therapies on immunogenicity of Mycobacterium paratuberculosis proteins.

Scand J Gastroenterol 2014 Feb 21;49(2):157-63. Epub 2013 Nov 21.

Division of Infectious Diseases, Department of Medicine, University of British Columbia , Vancouver, BC , Canada.

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http://dx.doi.org/10.3109/00365521.2013.857713DOI Listing
February 2014

Characterization of the gut-associated microbiome in inflammatory pouch complications following ileal pouch-anal anastomosis.

PLoS One 2013 24;8(9):e66934. Epub 2013 Sep 24.

Institute of Medical Science, University of Toronto, Toronto, Ontario, Canada ; Zane Cohen Centre for Digestive Diseases, Mount Sinai Hospital Inflammatory Bowel Disease Group, Toronto, Ontario, Canada.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3782502PMC
July 2014

Ileal pouch symptoms do not correlate with inflammation of the pouch.

Clin Gastroenterol Hepatol 2014 May 27;12(5):831-837.e2. Epub 2013 Sep 27.

Zane Cohen Centre for Digestive Diseases, Mount Sinai Hospital, Toronto, Ontario, Canada; Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Ontario, Canada; Department of Surgery, Mount Sinai Hospital, Toronto, Ontario, Canada; Department of Surgery, University of Toronto, Toronto, Ontario, Canada; Department of Health Policy, Management and Evaluation, University of Toronto, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1016/j.cgh.2013.09.027DOI Listing
May 2014

Association between a multi-locus genetic risk score and inflammatory bowel disease.

Bioinform Biol Insights 2013 19;7:143-52. Epub 2013 May 19.

The Centre for Applied Genomics, The Hospital for Sick Children, 101 College Street, Toronto, ON, Canada.

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http://dx.doi.org/10.4137/BBI.S11601DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3662393PMC
June 2013

Serum antibodies associated with complex inflammatory bowel disease.

Inflamm Bowel Dis 2013 Jun;19(7):1499-505

The Zane Cohen Centre for Digestive Diseases, Mount Sinai Hospital, University of Toronto, Toronto, Ontario, Canada.

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June 2013

Dense genotyping of immune-related disease regions identifies nine new risk loci for primary sclerosing cholangitis.

Nat Genet 2013 Jun 21;45(6):670-5. Epub 2013 Apr 21.

Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, UK.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3667736PMC
June 2013

Combined serological, genetic, and inflammatory markers differentiate non-IBD, Crohn's disease, and ulcerative colitis patients.

Inflamm Bowel Dis 2013 May;19(6):1139-48

Division of Gastroenterology and Hepatology, Inflammatory Bowel Disease Center, University of North Carolina School of Medicine, Chapel Hill, North Carolina 27599, USA.

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http://dx.doi.org/10.1097/MIB.0b013e318280b19eDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3792797PMC
May 2013

Expression quantitative trait loci analysis identifies associations between genotype and gene expression in human intestine.

Gastroenterology 2013 Jun 6;144(7):1488-96, 1496.e1-3. Epub 2013 Mar 6.

Zane Cohen Centre for Digestive Diseases, Samuel Lunenfeld Research Institute, Mount Sinai Hospital, University of Toronto, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1053/j.gastro.2013.03.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3775712PMC
June 2013

Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease.

Authors:
Luke Jostins Stephan Ripke Rinse K Weersma Richard H Duerr Dermot P McGovern Ken Y Hui James C Lee L Philip Schumm Yashoda Sharma Carl A Anderson Jonah Essers Mitja Mitrovic Kaida Ning Isabelle Cleynen Emilie Theatre Sarah L Spain Soumya Raychaudhuri Philippe Goyette Zhi Wei Clara Abraham Jean-Paul Achkar Tariq Ahmad Leila Amininejad Ashwin N Ananthakrishnan Vibeke Andersen Jane M Andrews Leonard Baidoo Tobias Balschun Peter A Bampton Alain Bitton Gabrielle Boucher Stephan Brand Carsten Büning Ariella Cohain Sven Cichon Mauro D'Amato Dirk De Jong Kathy L Devaney Marla Dubinsky Cathryn Edwards David Ellinghaus Lynnette R Ferguson Denis Franchimont Karin Fransen Richard Gearry Michel Georges Christian Gieger Jürgen Glas Talin Haritunians Ailsa Hart Chris Hawkey Matija Hedl Xinli Hu Tom H Karlsen Limas Kupcinskas Subra Kugathasan Anna Latiano Debby Laukens Ian C Lawrance Charlie W Lees Edouard Louis Gillian Mahy John Mansfield Angharad R Morgan Craig Mowat William Newman Orazio Palmieri Cyriel Y Ponsioen Uros Potocnik Natalie J Prescott Miguel Regueiro Jerome I Rotter Richard K Russell Jeremy D Sanderson Miquel Sans Jack Satsangi Stefan Schreiber Lisa A Simms Jurgita Sventoraityte Stephan R Targan Kent D Taylor Mark Tremelling Hein W Verspaget Martine De Vos Cisca Wijmenga David C Wilson Juliane Winkelmann Ramnik J Xavier Sebastian Zeissig Bin Zhang Clarence K Zhang Hongyu Zhao Mark S Silverberg Vito Annese Hakon Hakonarson Steven R Brant Graham Radford-Smith Christopher G Mathew John D Rioux Eric E Schadt Mark J Daly Andre Franke Miles Parkes Severine Vermeire Jeffrey C Barrett Judy H Cho

Nature 2012 Nov;491(7422):119-24

Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1HH, UK.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3491803PMC
November 2012