Publications

Identification of ten variants associated with risk of estrogen-receptor-negative breast cancer.
Nat Genet 2017 Dec 23;49(12):1767-1778. Epub 2017 Oct 23.
Genomics Center, Centre Hospitalier Universitaire de Québec Research Center, Laval University, Québec City, Québec, Canada.


Association analysis identifies 65 new breast cancer risk loci.
Nature 2017 Nov 23;551(7678):92-94. Epub 2017 Oct 23.
Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK.

Re: Does Exposure Prediction Bias Health-effect Estimation? The Relationship Between Confounding Adjustment and Exposure Prediction.
Epidemiology 2017 Jan;28(1):e2-e3
Division of Clinical Epidemiology Department of Medicine McGill University Health Center - RVH Montreal, QC, Canada Department of Health Sciences Carleton University Ottawa, ON, Canada Department of Sociology University of New Brunswick Fredericton, NB, Canada.

Association of breast cancer risk with genetic variants showing differential allelic expression: Identification of a novel breast cancer susceptibility locus at 4q21.
Oncotarget 2016 Dec;7(49):80140-80163
Genomics Center, Centre Hospitalier Universitaire de Québec Research Center, Laval University, Quebec, Canada.

rs2735383, located at a microRNA binding site in the 3'UTR of NBS1, is not associated with breast cancer risk.
Sci Rep 2016 Nov 15;6:36874. Epub 2016 Nov 15.
Department of Medical Oncology, Family Cancer Clinic, Erasmus MC Cancer Institute, Rotterdam, The Netherlands.

Particulate Oxidative Burden as a Predictor of Exhaled Nitric Oxide in Children with Asthma.
Environ Health Perspect 2016 Oct 6;124(10):1616-1622. Epub 2016 May 6.
Department of Environmental Health Sciences, School of Public Health and Health Sciences, University of Massachusetts, Amherst, Massachusetts, USA.

Evidence that the 5p12 Variant rs10941679 Confers Susceptibility to Estrogen-Receptor-Positive Breast Cancer through FGF10 and MRPS30 Regulation.
Am J Hum Genet 2016 Oct 15;99(4):903-911. Epub 2016 Sep 15.
Cancer Division, QIMR Berghofer Medical Research Institute, Brisbane, QLD 4006, Australia. Electronic address:

Fine scale mapping of the 17q22 breast cancer locus using dense SNPs, genotyped within the Collaborative Oncological Gene-Environment Study (COGs).
Sci Rep 2016 Sep 7;6:32512. Epub 2016 Sep 7.
Centre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge, Cambridge, UK.

Functional mechanisms underlying pleiotropic risk alleles at the 19p13.1 breast-ovarian cancer susceptibility locus.
Nat Commun 2016 Sep 7;7:12675. Epub 2016 Sep 7.
Department of Preventive Medicine, Keck School of Medicine, University of Southern California Norris Comprehensive Cancer Center, Los Angeles, California 90033, USA.

A panel study of the acute effects of personal exposure to household air pollution on ambulatory blood pressure in rural Indian women.
Environ Res 2016 May 27;147:331-42. Epub 2016 Feb 27.
Department of Epidemiology, Biostatistics and Occupational Health, McGill University, Montreal, QC, Canada; Institute for Health and Social Policy, McGill University, Montreal, QC, Canada. Electronic address:

Breast cancer risk variants at 6q25 display different phenotype associations and regulate ESR1, RMND1 and CCDC170.
Nat Genet 2016 Apr 29;48(4):374-86. Epub 2016 Feb 29.
Cancer Division, QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia.

Identification of four novel susceptibility loci for oestrogen receptor negative breast cancer.
Nat Commun 2016 Apr 27;7:11375. Epub 2016 Apr 27.
Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge CB1 8RN, UK.

BRCA2 Polymorphic Stop Codon K3326X and the Risk of Breast, Prostate, and Ovarian Cancers.
J Natl Cancer Inst 2016 Feb 19;108(2). Epub 2015 Nov 19.

Genetic variation in the immunosuppression pathway genes and breast cancer susceptibility: a pooled analysis of 42,510 cases and 40,577 controls from the Breast Cancer Association Consortium.
Hum Genet 2016 Jan 30;135(1):137-54. Epub 2015 Nov 30.
Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 581, 69120, Heidelberg, Germany.

Large-scale genomic analyses link reproductive aging to hypothalamic signaling, breast cancer susceptibility and BRCA1-mediated DNA repair.
Nat Genet 2015 Nov 28;47(11):1294-1303. Epub 2015 Sep 28.
Genetics of Complex Traits, University of Exeter Medical School, University of Exeter, Exeter, EX2 5DW, UK.


Investigating the role of transportation models in epidemiologic studies of traffic related air pollution and health effects.
Environ Res 2015 Jul 14;140:282-91. Epub 2015 Apr 14.
Department of Civil Engineering and Applied Mechanics, McGill University, Macdonald Engineering Building, Room 278b, 817 Sherbrooke St. W., Montréal, Québec, Canada H3A 2K6. Electronic address:

Polymorphisms in a Putative Enhancer at the 10q21.2 Breast Cancer Risk Locus Regulate NRBF2 Expression.
Am J Hum Genet 2015 Jul 11;97(1):22-34. Epub 2015 Jun 11.
Department of Genetics, QIMR Berghofer Medical Research Institute, Brisbane, QLD 4006, Australia. Electronic address:


Fine-mapping identifies two additional breast cancer susceptibility loci at 9q31.2.
Hum Mol Genet 2015 May 4;24(10):2966-84. Epub 2015 Feb 4.
Department of Non-Communicable Disease Epidemiology, London School of Hygiene and Tropical Medicine, London, UK.

Prediction of breast cancer risk based on profiling with common genetic variants.
J Natl Cancer Inst 2015 May 8;107(5). Epub 2015 Apr 8.
Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK (NM, PDPP, KM, MKB, QW, JD, RL, JBr, DFE); Centre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge, Cambridge, UK (PDPP, JT, AMD, MS, CL, CB, SA, MM, CSH, DFE); Division of Genetics and Epidemiology, The Institute of Cancer Research, London, UK (MNB, ASw, MJS); Copenhagen General Population Study, Herlev Hospital, Copenhagen University Hospital, Copenhagen, Denmark (SEB, BGN, SFN); Department of Clinical Biochemistry, Herlev Hospital, Copenhagen University Hospital, Copenhagen, Herlev, Denmark (SEB, BGN, SFN); Faculty of Health and Medical Sciences, Copenhagen University Hospital, Copenhagen, Herlev, Denmark (SEB, BGN); Department of Breast Surgery, Herlev Hospital, Copenhagen University Hospital, Copenhagen, Herlev, Denmark (HF); Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden (KC, HD, ME, KH, PHa); Department of Non-communicable Disease Epidemiology, London School of Hygiene and Tropical Medicine, London, UK (JP, IdSS, FD); Breakthrough Breast Cancer Research Centre, The Institute of Cancer Research, London, UK (NJ, AA, NO, MGC); Netherlands Cancer Institute, Antoni van Leeuwenhoek hospital, Amsterdam, the Netherlands (MKS, AB, SV, EJR); Division of Breast Cancer Research, Institute of Cancer Research, London, UK (ASw); Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD (JF, SJC, LB, ASi, MD); Department of Cancer Epidemiology and Prevention, M. Sklodowska-Curie Memorial Cancer Center and Institute of Oncology, Warsaw, Poland (JLis); Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN (FJC); Department of Health Sciences Research, Mayo Clinic, Rochester, MN (JEO, CV, VSP, SS); Vesalius Research Center, VIB, Leuven, Belgium (DL); Laboratory for Translational Genetics, Department of Oncology, University of

Genome-wide association analysis of more than 120,000 individuals identifies 15 new susceptibility loci for breast cancer.
Nat Genet 2015 Apr 9;47(4):373-80. Epub 2015 Mar 9.
1] Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK. [2] Centre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge, Cambridge, UK.

Inherited variants in the inner centromere protein (INCENP) gene of the chromosomal passenger complex contribute to the susceptibility of ER-negative breast cancer.
Carcinogenesis 2015 Feb 13;36(2):256-71. Epub 2015 Jan 13.
Molecular Genetics of Breast Cancer, German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany,

Identification and characterization of novel associations in the CASP8/ALS2CR12 region on chromosome 2 with breast cancer risk.
Hum Mol Genet 2015 Jan 28;24(1):285-98. Epub 2014 Aug 28.
Department of Oncology, University of Sheffield Medical School, Sheffield S10 2RX, UK

Fine-scale mapping of the 5q11.2 breast cancer locus reveals at least three independent risk variants regulating MAP3K1.
Am J Hum Genet 2015 Jan 18;96(1):5-20. Epub 2014 Dec 18.
Cancer Division, QIMR Berghofer Medical Research Institute, Brisbane, QLD 4029, Australia; School of Chemistry and Molecular Biosciences, University of Queensland, Brisbane, QLD 4072, Australia. Electronic address:

Genetic variation in mitotic regulatory pathway genes is associated with breast tumor grade.
Hum Mol Genet 2014 Nov 13;23(22):6034-46. Epub 2014 Jun 13.
Department of Health Sciences Research, Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, USA,

Common non-synonymous SNPs associated with breast cancer susceptibility: findings from the Breast Cancer Association Consortium.
Hum Mol Genet 2014 Nov 18;23(22):6096-111. Epub 2014 Jun 18.
Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, Centre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge, Cambridge, UK.

Evidence that breast cancer risk at the 2q35 locus is mediated through IGFBP5 regulation.
Nat Commun 2014 Sep 23;4:4999. Epub 2014 Sep 23.
Centre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge, Cambridge CB1 8RN, UK.

Genetic variation at CYP3A is associated with age at menarche and breast cancer risk: a case-control study.
Breast Cancer Res 2014 May 26;16(3):R51. Epub 2014 May 26.
Breakthrough Breast Cancer Research Centre, The Institute of Cancer Research, 237 Fulham Road, London, SW3 6JB, UK.

Genetic predisposition to in situ and invasive lobular carcinoma of the breast.
PLoS Genet 2014 Apr 17;10(4):e1004285. Epub 2014 Apr 17.
Division of Genetics and Epidemiology, Institute of Cancer Research, London, United Kingdom; Breakthrough Breast Cancer Research Centre, The Institute of Cancer Research, London, United Kingdom.

Spatial association between ambient fine particulate matter and incident hypertension.
Circulation 2014 Feb 4;129(5):562-9. Epub 2013 Nov 4.
From Public Health Ontario, Toronto, Ontario, Canada (H.C., J.C.K., R.C.); Dalla Lana School of Public Health, University of Toronto, Toronto, Ontario, Canada (H.C., J.C.K., P.J.V., R.C.); Institute for Clinical Evaluative Sciences, Toronto, Ontario, Canada (H.C., J.C.K., A.K.); Population Studies Division, Health Canada, Ottawa, Ontario, Canada (R.T.B.); Department of Family and Community Medicine, University of Toronto, Toronto, Ontario, Canada (J.C.K.); Department of Health Sciences, Carleton University, Ottawa, Ontario, Canada (P.J.V.); Department of Medicine, McGill University, Montreal, Quebec, Canada (M.S.G.); Division of Clinical Epidemiology, McGill University Health Centre, Montreal, Quebec, Canada (M.S.G.); Division of Cardiovascular Medicine, University of Michigan Medical School, Ann Arbor (R.D.B.); Department of Physics and Atmospheric Science, Dalhousie University, Halifax, Nova Scotia, Canada (A.v.D., R.V.M.); Division of Environmental Health Sciences, School of Public Health, University of California, Berkeley (M.J.); Harvard-Smithsonian Center for Astrophysics, Cambridge, MA (R.V.M.); and Air Quality Research Division, Environment Canada, Toronto, Ontario, Canada (J.R.B.).

A cohort study of intra-urban variations in volatile organic compounds and mortality, Toronto, Canada.
Environ Pollut 2013 Dec 29;183:30-9. Epub 2013 Jan 29.
Population Studies Division, Health Canada, Ottawa, Ontario, Canada; Department of Epidemiology and Community Medicine, University of Ottawa, Ottawa, Ontario, Canada. Electronic address:

Fine-scale mapping of the FGFR2 breast cancer risk locus: putative functional variants differentially bind FOXA1 and E2F1.
Am J Hum Genet 2013 Dec 27;93(6):1046-60. Epub 2013 Nov 27.
CRUK Cambridge Institute and Department of Oncology, University of Cambridge, Li Ka Shing Centre, Robinson Way, Cambridge CB2 0RE, UK. Electronic address:

Associations between ambient air pollution and daily mortality among elderly persons in Montreal, Quebec.
Sci Total Environ 2013 Oct 19;463-464:931-42. Epub 2013 Jul 19.
Department of Medicine, McGill University, Montreal, Quebec, Canada; Division of Clinical Epidemiology, McGill University Health Centre, 687 Pine Ave. W., R4.29, Montreal, Quebec H3A 1A1, Canada. Electronic address:

Large-scale genotyping identifies 41 new loci associated with breast cancer risk.
Nat Genet 2013 Apr;45(4):353-61, 361e1-2
Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK.

Multiple independent variants at the TERT locus are associated with telomere length and risks of breast and ovarian cancer.
Nat Genet 2013 Apr;45(4):371-84, 384e1-2
Copenhagen General Population Study, Herlev Hospital, Copenhagen University Hospital, University of Copenhagen, Copenhagen, Denmark.

Genome-wide association studies identify four ER negative-specific breast cancer risk loci.
Nat Genet 2013 Apr;45(4):392-8, 398e1-2
1] Division of Genetics and Epidemiology, Institute of Cancer Research, Sutton, UK. [2] Breakthrough Breast Cancer Research Centre, The Institute of Cancer Research, London, UK. [3].

Functional variants at the 11q13 risk locus for breast cancer regulate cyclin D1 expression through long-range enhancers.
Am J Hum Genet 2013 Apr 27;92(4):489-503. Epub 2013 Mar 27.
School of Chemistry and Molecular Biosciences, The University of Queensland, Brisbane, Queensland 4072, Australia.


Associations between cigarette smoking, obesity, sociodemographic characteristics and remote-sensing-derived estimates of ambient PM2.5: results from a Canadian population-based survey.
Occup Environ Med 2011 Dec 24;68(12):920-7. Epub 2011 May 24.
Population Studies Division, Health Canada, 50 Columbine Driveway, Room 165, PL0801A, Ottawa, ON K1A 0K9, Canada.

Panel discussion review: session two--interpretation of observed associations between multiple ambient air pollutants and health effects in epidemiologic analyses.
J Expo Sci Environ Epidemiol 2007 Dec;17 Suppl 2:S83-9
National Center for Environmental Assessment, US Environmental Protection Agency, Research Triangle Park, NC 27711, USA.

MicroRNA related polymorphisms and breast cancer risk.
PLoS One 2014 12;9(11):e109973. Epub 2014 Nov 12.
Department of Obstetrics and Gynecology, University of Helsinki and Helsinki University Central Hospital, Helsinki, Finland.

Fine-Mapping of the 1p11.2 Breast Cancer Susceptibility Locus.
PLoS One 2016 24;11(8):e0160316. Epub 2016 Aug 24.
Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD, United States of America.

Comparison of spatiotemporal prediction models of daily exposure of individuals to ambient nitrogen dioxide and ozone in Montreal, Canada.
Environ Res 2017 07 28;156:201-230. Epub 2017 Mar 28.
Department of Medicine, McGill University, Montreal, Quebec, Canada; Division of Clinical Epidemiology, McGill University Health Centre, Montreal, Quebec, Canada.


OF