Publications by authors named "Mark Roest"

98Publications

Current methods of measuring platelet activity: pros and cons.

Blood Coagul Fibrinolysis 2020 Oct;31(7):426-433

Synapse Research Institute, Maastricht, the Netherlands.

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http://dx.doi.org/10.1097/MBC.0000000000000941DOI Listing
October 2020

Flow cytometric analysis of platelet function to improve the recognition of thrombocytopathy.

Thromb Res 2020 Jun 24;194:183-189. Epub 2020 Jun 24.

Coagulation Laboratory, Department of Laboratory Medicine, Ghent University Hospital, Ghent, Belgium; Department of Diagnostic Sciences, Ghent University, Ghent, Belgium.

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http://dx.doi.org/10.1016/j.thromres.2020.06.037DOI Listing
June 2020

Acute exacerbations of COPD are associated with a prothrombotic state through platelet-monocyte complexes, endothelial activation and increased thrombin generation.

Respir Med 2020 Sep 25;171:106094. Epub 2020 Jul 25.

Department of Respiratory Medicine, Gelre Ziekenhuizen, Apeldoorn, the Netherlands; Department of Respiratory Medicine, Maastricht University Medical Centre, Maastricht, the Netherlands; NUTRIM School of Nutrition and Translational Research in Metabolism, University of Maastricht, Maastricht, the Netherlands.

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http://dx.doi.org/10.1016/j.rmed.2020.106094DOI Listing
September 2020

Interplay between platelets and coagulation.

Blood Rev 2020 Jul 12:100733. Epub 2020 Jul 12.

Department of Biochemistry, Cardiovascular Research Institute Maastricht (CARIM), Maastricht University, Maastricht, the Netherlands; Synapse Research Institute, Maastricht, the Netherlands. Electronic address:

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http://dx.doi.org/10.1016/j.blre.2020.100733DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7354275PMC
July 2020

Beta-2-glycoprotein I as a biomarker for sepsis in critically ill patients in the intensive care unit: a prospective cohort study.

Crit Care 2020 06 15;24(1):341. Epub 2020 Jun 15.

Department of Intensive Care Medicine, University Medical Centre, University of Utrecht, Heidelberglaan 100, 3584 CX, Utrecht, The Netherlands.

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http://dx.doi.org/10.1186/s13054-020-03066-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7296730PMC
June 2020

A novel assay for studying the involvement of blood cells in whole blood thrombin generation.

J Thromb Haemost 2020 06 30;18(6):1291-1301. Epub 2020 Mar 30.

Synapse Research Institute, Maastricht, The Netherlands.

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http://dx.doi.org/10.1111/jth.14786DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7317846PMC
June 2020

Osteoprotegerin is Higher in Sepsis Than in Noninfectious SIRS and Predicts 30-Day Mortality of SIRS Patients in the Intensive Care.

J Appl Lab Med 2019 01 16;3(4):559-568. Epub 2018 Jul 16.

Intensive Care Center, University Medical Center Utrecht, University Utrecht, Utrecht, the Netherlands.

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http://dx.doi.org/10.1373/jalm.2018.026559DOI Listing
January 2019

A Synthetic Triple Helical Collagen Peptide as a New Agonist for Flow Cytometric Measurement of GPVI-Specific Platelet Activation.

Thromb Haemost 2019 Dec 21;119(12):2005-2013. Epub 2019 Oct 21.

Department of Biochemistry, Cardiovascular Research Institute Maastricht (CARIM), Maastricht University, Maastricht, The Netherlands.

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http://dx.doi.org/10.1055/s-0039-1697660DOI Listing
December 2019

The anticoagulant effect of dabigatran is reflected in the lag time and time-to-peak, but not in the endogenous thrombin potential or peak, of thrombin generation.

Thromb Res 2018 11 6;171:160-166. Epub 2018 Oct 6.

Université catholique de Louvain, CHU UCL Namur, Namur Thrombosis and Hemostasis Center, Hematology Laboratory, Namur, Belgium.

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https://linkinghub.elsevier.com/retrieve/pii/S00493848183056
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http://dx.doi.org/10.1016/j.thromres.2018.10.005DOI Listing
November 2018

Effects of Repeated Bouts of Exercise on the Hemostatic System.

Semin Thromb Hemost 2018 Nov 5;44(8):710-722. Epub 2018 Oct 5.

Cardiovascular Research Institute Maastricht, Maastricht University Medical Centre, Maastricht University, Maastricht, The Netherlands.

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http://www.thieme-connect.de/DOI/DOI?10.1055/s-0038-1673619
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http://dx.doi.org/10.1055/s-0038-1673619DOI Listing
November 2018

Myeloperoxidase can differentiate between sepsis and non-infectious SIRS and predicts mortality in intensive care patients with SIRS.

Intensive Care Med Exp 2017 Sep 15;5(1):43. Epub 2017 Sep 15.

Department of Intensive Care Medicine, University Medical Centre, University of Utrecht, Heidelberglaan 100, 3584 CX, Utrecht, The Netherlands.

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http://dx.doi.org/10.1186/s40635-017-0157-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5602808PMC
September 2017

Interdependence between osteoprotegerin and active von Willebrand factor in long-term cardiovascular mortality prediction in patients undergoing percutaneous coronary intervention.

Thromb Haemost 2017 08 20;117(9):1730-1738. Epub 2017 Jul 20.

Jolanta Siller-Matula, MD, PhD, Department of Cardiology, Medical University of Vienna, Währinger Gürtel 18-20, A-1090 Vienna, Austria, E-mail: , or, Bernd Jilma, MD, Department of Clinical Pharmacology, Medical University of Vienna, Währinger Gürtel 18-20, A-1090 Vienna, Austria, E-mail:

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http://dx.doi.org/10.1160/TH17-02-0087DOI Listing
August 2017

Soluble P-selectin as a Biomarker for Infection and Survival in Patients With a Systemic Inflammatory Response Syndrome on the Intensive Care Unit.

Biomark Insights 2017 7;12:1177271916684823. Epub 2017 Feb 7.

Department of Intensive Care Medicine, University Medical Center Utrecht, Utrecht, The Netherlands.

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http://dx.doi.org/10.1177/1177271916684823DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5345948PMC
February 2017

Baseline thrombospondin-1 concentrations are not associated with mortality in septic patients: a single-center cohort study on the intensive care unit.

Intensive Care Med Exp 2017 Dec 25;5(1). Epub 2017 Jan 25.

Intensive Care Department, University Medical Center Utrecht, University Utrecht, Utrecht, the Netherlands.

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http://dx.doi.org/10.1186/s40635-017-0120-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5267614PMC
December 2017

Normalization methods in time series of platelet function assays: A SQUIRE compliant study.

Medicine (Baltimore) 2016 Jul;95(28):e4188

aDepartment of Anesthesiology, Intensive Care, Emergency Medicine and Pain Therapy, Ziekenhuis Oost-Limburg, Genk, Belgium bDepartment of Critical Care Medicine, Jinhua Hospital of Zhejiang University, Zhejiang, P.R. China cSynapse Research Institute, Maastricht, The Netherlands dDepartment of Organizational Sciences, University of Belgrade, Belgrade, Serbia eDepartment of Infection and Liver Diseases, Liver Research Center, Wenzhou Medical University, Wenzhou, China fCentral Diagnostic Laboratory, Maastricht University Medical Centre (MUMC+) gDepartment of Anaesthesiology & Pain Treatment, Maastricht University Medical Centre, Maastricht, The Netherlands hDepartment of Anesthesiology, ICU and Perioperative Medicine, HMC, Doha, Qatar.

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http://dx.doi.org/10.1097/MD.0000000000004188DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4956811PMC
July 2016

Functional recovery of stored platelets after transfusion.

Transfusion 2016 05 2;56(5):1030-7. Epub 2016 Mar 2.

Department of Clinical Chemistry and Haematology, University Medical Center, Utrecht, the Netherlands.

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http://dx.doi.org/10.1111/trf.13544DOI Listing
May 2016

Postpartum Circulating Markers of Inflammation and the Systemic Acute-Phase Response After Early-Onset Preeclampsia.

Hypertension 2016 Feb 28;67(2):404-14. Epub 2015 Dec 28.

From the Division of Woman and Baby (B.B.v.R., H.W.B., J.H.V., E.D.P.U., S.V.K., A.F.) and Laboratory for Clinical Chemistry and Hematology, University Medical Center Utrecht (M.R.), Utrecht, The Netherlands; Centre for Trophoblast Disease, University of Cambridge, Cambridge, United Kingdom (J.H.V.); Department of Clinical Epidemiology and Hematology, Leiden University Medical Center, Leiden, The Netherlands (J.G.v.d.B.); Department of Medical Microbiology, St Antonius Hospital Nieuwegein, Nieuwegein, The Netherlands (G.T.R.); Department of Science, University College Roosevelt, Middelburg, The Netherlands (G.T.R.); and Academic Unit of Human Development and Health, University of Southampton, Southampton, United Kingdom (B.B.v.R.).

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https://www.ahajournals.org/doi/10.1161/HYPERTENSIONAHA.115.
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http://dx.doi.org/10.1161/HYPERTENSIONAHA.115.06455DOI Listing
February 2016

Risk factor analysis of cerebral white matter hyperintensities in children with sickle cell disease.

Br J Haematol 2016 Jan 22;172(2):274-84. Epub 2015 Oct 22.

Department of Paediatric Haematology, Immunology and Infectious Diseases, Emma Children's Hospital, Academic Medical Centre, Amsterdam, The Netherlands.

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http://dx.doi.org/10.1111/bjh.13819DOI Listing
January 2016

Platelet density per monocyte predicts adverse events in patients after percutaneous coronary intervention.

Thromb Haemost 2016 Jan 1;115(2):353-60. Epub 2015 Oct 1.

Dr. Bert Rutten, Department of Clinical Chemistry and Haematology, UMC Utrecht, Utrecht, the Netherlands, E-mail:

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http://dx.doi.org/10.1160/TH15-03-0227DOI Listing
January 2016

In Vitro Hemocompatibility Testing of Dyneema Purity Fibers in Blood Contact.

Innovations (Phila) 2015 May-Jun;10(3):195-201

From the Departments of *Experimental Cardiology, †Clinical Chemistry and Haematology, ‡Vascular Surgery, and §Cardio-Thoracic Surgery, UMC Utrecht, Netherlands.

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http://dx.doi.org/10.1097/IMI.0000000000000163DOI Listing
May 2016

Baseline Platelet Activation and Reactivity in Patients with Critical Limb Ischemia.

PLoS One 2015 6;10(7):e0131356. Epub 2015 Jul 6.

Department of Vascular Surgery, University Medical Center Utrecht, Utrecht, 3584CX, The Netherlands.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0131356PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4492682PMC
March 2016

Normal platelet activation profile in patients with peripheral arterial disease on aspirin.

Thromb Res 2015 Mar 6;135(3):513-20. Epub 2015 Jan 6.

Departments of Biochemistry and Internal Medicine, Cardiovascular Research Institute Maastricht (CARIM), Maastricht University Medical Centre, Maastricht, The Netherlands. Electronic address:

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http://dx.doi.org/10.1016/j.thromres.2014.12.029DOI Listing
March 2015

Coagulation activation during air travel is not initiated via the extrinsic pathway.

Br J Haematol 2015 Jun 17;169(6):903-5. Epub 2014 Dec 17.

Department of Clinical Epidemiology, Leiden University Medical Centre, Leiden, the Netherlands.

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http://dx.doi.org/10.1111/bjh.13257DOI Listing
June 2015

Reduced platelet hyperreactivity and platelet-monocyte aggregation in HIV-infected individuals receiving a raltegravir-based regimen.

AIDS 2014 Sep;28(14):2091-6

aDepartment of Internal Medicine, Radboud university medical center, Nijmegen, The Netherlands bCenter for Tropical and Infectious Disease (CENTRID), Faculty of Medicine Diponegoro University, Dr Kariadi Hospital, Semarang, Indonesia cDepartment of Clinical Chemistry and Haematology, University Medical Center, Utrecht, The Netherlands.

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http://dx.doi.org/10.1097/QAD.0000000000000415DOI Listing
September 2014

Endocannabinoids control platelet activation and limit aggregate formation under flow.

PLoS One 2014 29;9(9):e108282. Epub 2014 Sep 29.

Department of Clinical Chemistry and Haematology, Utrecht University Medical Center, Utrecht, The Netherlands.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0108282PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4180465PMC
November 2015

Hemocompatibility assessment of two siRNA nanocarrier formulations.

Pharm Res 2014 Nov 20;31(11):3127-35. Epub 2014 May 20.

Department of Pharmaceutics, Utrecht Institute for Pharmaceutical Sciences, Faculty of Science, Utrecht University, Utrecht, The Netherlands.

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http://link.springer.com/content/pdf/10.1007%2Fs11095-014-14
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http://link.springer.com/10.1007/s11095-014-1405-4
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http://dx.doi.org/10.1007/s11095-014-1405-4DOI Listing
November 2014

Quantitative proteomics analysis reveals similar release profiles following specific PAR-1 or PAR-4 stimulation of platelets.

Cardiovasc Res 2014 Jul 28;103(1):140-6. Epub 2014 Apr 28.

Laboratory for Clinical Chemistry and Haematology, UMC Utrecht, Utrecht, The Netherlands

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http://dx.doi.org/10.1093/cvr/cvu113DOI Listing
July 2014

Platelet degranulation and glycoprotein IIbIIIa opening are not related to bleeding phenotype in severe haemophilia A patients.

Thromb Haemost 2014 Jun 30;111(6):1022-30. Epub 2014 Jan 30.

Mark Roest, Department of Clinical Chemistry and Hematology, University Medical Center Utrecht, Heidelberglaan 100 (G03.550), 3584 CX Utrecht, The Netherlands, Tel.: +31 88 7555555, Fax: +31 88 7555418, E-mail:

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http://dx.doi.org/10.1160/TH13-07-0546DOI Listing
June 2014

Active von Willebrand factor predicts 28-day mortality in patients with systemic inflammatory response syndrome.

Blood 2014 Apr 23;123(14):2153-6. Epub 2014 Jan 23.

Department of Clinical Chemistry and Hematology, and.

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http://dx.doi.org/10.1182/blood-2013-08-508093DOI Listing
April 2014

Plasmin cleavage of von Willebrand factor as an emergency bypass for ADAMTS13 deficiency in thrombotic microangiopathy.

Circulation 2014 Mar 21;129(12):1320-31. Epub 2014 Jan 21.

Laboratory of Clinical Chemistry and Haematology (C.T., S.d.M., M.W.J.S., A.D.B., M.R., R.F., P.G.d.G., C.M.) and Laboratory of Experimental Cardiology (C.T., G.P.), UMC Utrecht, Utrecht, The Netherlands; and Laboratory for Thrombosis Research, IRF Life Sciences, KU Leuven Kulak, Kortrijk, Belgium (S.F.D.M., K.V.).

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http://dx.doi.org/10.1161/CIRCULATIONAHA.113.006727DOI Listing
March 2014

FLow-induced PRotrusions (FLIPRs): a platelet-derived platform for the retrieval of microparticles by monocytes and neutrophils.

Circ Res 2014 Feb 9;114(5):780-91. Epub 2014 Jan 9.

From the Laboratory of Clinical Chemistry and Haematology (C.T., H.F.H., R.T.U., C.M., P.G.d.G., M.R.), Laboratory of Experimental Cardiology (C.T., G.P., I.E.H.), and Cell Microscopy Center, Department of Cell Biology (H.F.H.), UMC Utrecht, Utrecht, The Netherlands; UMR-S949 INSERM, EFS-Alsace, Université de Strasbourg, Strasbourg, France (A.E., C.G.); Department of Clinical Chemistry, AMC Amsterdam, Amsterdam, The Netherlands (R.N.); and Department of Biochemistry, University of Cambridge, Cambridge, United Kingdom (R.W.F.).

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https://www.ahajournals.org/doi/10.1161/CIRCRESAHA.114.30236
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http://dx.doi.org/10.1161/CIRCRESAHA.114.302361DOI Listing
February 2014

Pre-existing endothelial cell activation predicts vasoplegia after mitral valve surgery.

Interact Cardiovasc Thorac Surg 2013 Sep 4;17(3):523-30. Epub 2013 Jun 4.

Department of Cardiothoracic Surgery, Leiden University Medical Center, Leiden, Netherlands.

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http://dx.doi.org/10.1093/icvts/ivt243DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3745151PMC
September 2013

Platelet Activation Test in Unprocessed Blood (Pac-t-UB) to Monitor Platelet Concentrates and Whole Blood of Thrombocytopenic Patients.

Transfus Med Hemother 2013 Apr 28;40(2):117-25. Epub 2013 Mar 28.

Department of Clinical Chemistry and Hematology, University Medical Center Utrecht, Apeldoorn, The Netherlands.

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http://dx.doi.org/10.1159/000350688DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3638932PMC
April 2013

High precision platelet releasate definition by quantitative reversed protein profiling--brief report.

Arterioscler Thromb Vasc Biol 2013 Jul 2;33(7):1635-8. Epub 2013 May 2.

Biomolecular Mass Spectrometry and Proteomics, Utrecht Institute for Pharmaceutical Sciences and Bijvoet Center for Biomolecular Research, Utrecht University, Utrecht, The Netherlands.

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https://www.ahajournals.org/doi/10.1161/ATVBAHA.113.301147
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http://dx.doi.org/10.1161/ATVBAHA.113.301147DOI Listing
July 2013

Cardiovascular disease risk factors in women with a history of early-onset preeclampsia.

Obstet Gynecol 2013 May;121(5):1040-8

Division of Human Development and Health, University of Southampton, Southamptom, United Kingdom.

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http://dx.doi.org/10.1097/AOG.0b013e31828ea3b5DOI Listing
May 2013

Targeted phosphotyrosine profiling of glycoprotein VI signaling implicates oligophrenin-1 in platelet filopodia formation.

Arterioscler Thromb Vasc Biol 2013 Jul 25;33(7):1538-43. Epub 2013 Apr 25.

Biomolecular Mass Spectrometry and Proteomics and Bijvoet Center for Biomolecular Research and Utrecht Institute for Pharmaceutical Sciences, Utrecht University, Utrecht, The Netherlands.

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http://dx.doi.org/10.1161/ATVBAHA.112.300916DOI Listing
July 2013

Chronic dysfunction of the endothelium is associated with mortality in acute coronary syndrome patients.

Thromb Res 2013 Mar 27;131(3):198-203. Epub 2012 Dec 27.

Department of Clinical Chemistry and Haematology, University Medical Center Utrecht, The Netherlands.

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http://dx.doi.org/10.1016/j.thromres.2012.12.001DOI Listing
March 2013

Flow cytometric assessment of agonist-induced P-selectin expression as a measure of platelet quality in stored platelet concentrates.

Transfusion 2013 Aug 7;53(8):1780-7. Epub 2012 Dec 7.

Center for Clinical Transfusion Research, Sanquin Research, Leiden University Medical Center, Leiden, The Netherlands.

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http://dx.doi.org/10.1111/trf.12001DOI Listing
August 2013

Platelets of patients with chronic kidney disease demonstrate deficient platelet reactivity in vitro.

BMC Nephrol 2012 Sep 28;13:127. Epub 2012 Sep 28.

Department of Clinical Chemistry and Hematology, University Medical Center Utrecht, Heidelberglaan 100, 3584, CX, Utrecht, The Netherlands.

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http://dx.doi.org/10.1186/1471-2369-13-127DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3473261PMC
September 2012

Platelet interaction with the vessel wall.

Handb Exp Pharmacol 2012 (210):87-110

Department of Clinical Chemistry and Haematology (G03.550), University Medical Center Utrecht, Heidelberglaan 100, 3584 CX, Utrecht, The Netherlands.

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http://link.springer.com/10.1007/978-3-642-29423-5_4
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http://dx.doi.org/10.1007/978-3-642-29423-5_4DOI Listing
January 2013

Measurement of platelet responsiveness using antibody-coated magnetic beads for lab-on-a-chip applications.

Platelets 2012 6;23(8):626-32. Epub 2012 Feb 6.

Department of Applied Physics, Eindhoven University of Technology, Eindhoven, The Netherlands.

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http://dx.doi.org/10.3109/09537104.2011.651516DOI Listing
April 2013

The platelet P2Y12 receptor contributes to granule secretion through Ephrin A4 receptor.

Platelets 2012 24;23(8):617-25. Epub 2012 Jan 24.

Laboratory for Thrombosis and Haemostasis, Department of Clinical Chemistry and Haematology, University Medical Center Utrecht, Heidelberglaan 100, Utrecht, The Netherlands.

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http://dx.doi.org/10.3109/09537104.2011.645924DOI Listing
April 2013

Plasma concentration of von Willebrand factor predicts mortality in patients on chronic renal replacement therapy.

Nephrol Dial Transplant 2012 Jun 20;27(6):2452-7. Epub 2011 Dec 20.

Department of Clinical Chemistry and Haematology, Jeroen Bosch Hospital, 's-Hertogenbosch, The Netherlands.

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http://dx.doi.org/10.1093/ndt/gfr735DOI Listing
June 2012

Collagen stimulation of platelets induces a rapid spatial response of cAMP and cGMP signaling scaffolds.

Mol Biosyst 2011 Jul 20;7(7):2311-9. Epub 2011 May 20.

Biomolecular Mass Spectrometry and Proteomics Group, Bijvoet Center for Biomolecular Research and Utrecht Institute for Pharmaceutical Sciences, Utrecht University, Padualaan 8, 3584 CH Utrecht, The Netherlands.

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http://dx.doi.org/10.1039/c1mb05145hDOI Listing
July 2011

Up-regulation of platelet activation in hemophilia A.

Haematologica 2011 Jun 21;96(6):888-95. Epub 2011 Mar 21.

Department of Clinical Chemistry and Hematology/Van Creveldlaboratory, University Medical Center Utrecht, Heidelberglaan 100 (G03.550), 3584 CX Utrecht, The Netherlands.

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http://www.haematologica.org/cgi/doi/10.3324/haematol.2011.0
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http://dx.doi.org/10.3324/haematol.2011.042663DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3105651PMC
June 2011

High levels of urinary F2-isoprostanes predict cardiovascular mortality in postmenopausal women.

J Clin Lipidol 2008 Aug 13;2(4):298-303. Epub 2008 Jun 13.

Research Laboratory of the Department of Clinical Chemistry and Haematology, University Medical Center Utrecht, the Netherlands.

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http://dx.doi.org/10.1016/j.jacl.2008.06.004DOI Listing
August 2008

Paraoxonase (PON1) is associated with familial combined hyperlipidemia.

Atherosclerosis 2008 Jul 21;199(1):87-94. Epub 2007 Dec 21.

Department of Clinical Chemistry and Haematology, UMC Utrecht, Utrecht, The Netherlands.

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http://dx.doi.org/10.1016/j.atherosclerosis.2007.10.017DOI Listing
July 2008

Analysis of case-cohort data: a comparison of different methods.

J Clin Epidemiol 2007 Apr 5;60(4):350-5. Epub 2007 Feb 5.

Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Room Str. 6.131, PO Box 85500, 3508 GA Utrecht, The Netherlands.

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http://dx.doi.org/10.1016/j.jclinepi.2006.06.022DOI Listing
April 2007

Paraoxonase genotype and carotid intima-media thickness in children with familial hypercholesterolemia.

Eur J Cardiovasc Prev Rehabil 2006 Jun;13(3):464-6

Research Laboratory of the Department of Clinical Chemistry, University Medical Center, Utrecht, The Netherlands.

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http://dx.doi.org/10.1097/00149831-200606000-00025DOI Listing
June 2006

High-throughput genotyping with infrared fluorescence allele specific hybridization (iFLASH): a simple, reliable and low-cost alternative.

Clin Biochem 2006 Jul 19;39(7):739-45. Epub 2006 Apr 19.

Research Laboratory of the Department of Clinical Chemistry, University Medical Center Utrecht, Utrecht, The Netherlands.

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http://dx.doi.org/10.1016/j.clinbiochem.2006.02.012DOI Listing
July 2006

Non-transferrin-bound iron and risk of coronary heart disease in postmenopausal women.

Circulation 2006 Apr 17;113(16):1942-9. Epub 2006 Apr 17.

Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, The Netherlands.

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http://dx.doi.org/10.1161/CIRCULATIONAHA.105.545350DOI Listing
April 2006

A randomized, masked, cross-over trial of lisinopril for inflammatory macular edema.

Am J Ophthalmol 2006 Apr;141(4):646-51

F.C. Donders Institute of Ophthalmology, Department of Hematology, University Medical Center, Utrecht, The Netherlands.

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http://dx.doi.org/10.1016/j.ajo.2005.11.056DOI Listing
April 2006

HFE genotypes and dietary heme iron: no evidence of strong gene-nutrient interaction on serum ferritin concentrations in middle-aged women.

Nutr Metab Cardiovasc Dis 2006 Jan;16(1):60-8

Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, The Netherlands.

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http://dx.doi.org/10.1016/j.numecd.2005.07.008DOI Listing
January 2006

Polymorphisms in the estrogen receptor alpha gene and mammographic density.

Cancer Epidemiol Biomarkers Prev 2005 Nov;14(11 Pt 1):2655-60

Julius Center for Health Sciences and Primary Care University Medical Center, Utrecht Mail Drop Str. 6.131, 3508 GA Utrecht, the Netherlands.

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http://dx.doi.org/10.1158/1055-9965.EPI-05-0398DOI Listing
November 2005

The estrogen receptor alpha gene and breast cancer risk (The Netherlands).

Cancer Causes Control 2005 Dec;16(10):1195-202

Julius Center for Health Sciences and Primary Care, UMC Utrecht, Room St. 6.131, PO Box 85500, 3508, GA Utrecht, The Netherlands.

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http://dx.doi.org/10.1007/s10552-005-0307-5DOI Listing
December 2005

Cumulative genetic defects in carcinogen metabolism may increase breast cancer risk (The Netherlands).

Cancer Causes Control 2005 Aug;16(6):675-81

Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, PO Box 85500, 3508 GA Utrecht, The Netherlands.

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http://dx.doi.org/10.1007/s10552-005-1227-0DOI Listing
August 2005

Serum ferritin is a risk factor for stroke in postmenopausal women.

Stroke 2005 Aug 7;36(8):1637-41. Epub 2005 Jul 7.

Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, HP Str 6.131, PO Box 85500, 3508 GA Utrecht, The Netherlands.

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http://dx.doi.org/10.1161/01.STR.0000173172.82880.72DOI Listing
August 2005

Paraoxonase-1 and linoleic acid oxidation in familial hypercholesterolemia.

Biochem Biophys Res Commun 2005 Aug;333(3):787-93

Research Laboratory of the Department of Clinical Chemistry, UMC Utrecht, Utrecht, The Netherlands. T.M.van

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http://dx.doi.org/10.1016/j.bbrc.2005.05.176DOI Listing
August 2005

Cyp17, urinary sex steroid levels and breast cancer risk in postmenopausal women.

Cancer Epidemiol Biomarkers Prev 2005 Apr;14(4):815-20

Julius Center for Health Sciences and Primary Care, UMC Utrecht, 3508 GA Utrecht, The Netherlands.

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http://dx.doi.org/10.1158/1055-9965.EPI-04-0197DOI Listing
April 2005

Elevated levels of D-dimer and fragment 1+2 upon central venous catheter insertion and factor V Leiden predict subclavian vein thrombosis.

Haematologica 2005 Apr;90(4):499-504

Department of Haematology, University Medical Center Utrecht, Heidelberglaan 100, 3584 CX Utrecht, The Netherlands.

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April 2005

Variation at the paraoxonase gene locus contributes to carotid arterial wall thickness in subjects with familial hypercholesterolemia.

Clin Biochem 2005 Feb;38(2):123-7

Research Laboratory of the Department of Clinical Chemistry, G03-550, UMC Utrecht, Heidelberglaan 100, 3584 CX Utrecht, The Netherlands.

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http://dx.doi.org/10.1016/j.clinbiochem.2004.10.005DOI Listing
February 2005

Trace microalbuminuria in inflammatory cystoid macular edema.

Am J Ophthalmol 2004 Dec;138(6):1010-5

F.C. Donders Institute of Ophthalmology, University Medical Center, Utrecht, The Netherlands.

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http://linkinghub.elsevier.com/retrieve/pii/S000293940400946
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http://dx.doi.org/10.1016/j.ajo.2004.07.056DOI Listing
December 2004

Paraoxonase genotype, LDL-oxidation and carotid atherosclerosis in male life-long smokers.

Free Radic Res 2004 Jun;38(6):553-60

Research Laboratory of the Department of Clinical Chemistry, University Medical Centre Utrecht, Utrecht, The Netherlands.

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http://dx.doi.org/10.1080/1071576042000206496DOI Listing
June 2004

beta2-glycoprotein I-dependent lupus anticoagulant highly correlates with thrombosis in the antiphospholipid syndrome.

Blood 2004 Dec 17;104(12):3598-602. Epub 2004 Aug 17.

Department of Haematology, G03.647, University Medical Centre Utrecht, PO Box 85500, 3508 GA Utrecht, the Netherlands.

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http://dx.doi.org/10.1182/blood-2004-03-1107DOI Listing
December 2004

Single step high-throughput determination of Toll-like receptor 4 polymorphisms.

J Immunol Methods 2004 Jun;289(1-2):81-7

Research Laboratory of the Department of Clinical Chemistry, University Medical Center Utrecht, The Netherlands.

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http://dx.doi.org/10.1016/j.jim.2004.03.013DOI Listing
June 2004

The V89L polymorphism in the 5-alpha-reductase type 2 gene and risk of breast cancer.

Cancer Epidemiol Biomarkers Prev 2003 Nov;12(11 Pt 1):1194-9

Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, the Netherlands.

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November 2003

Editorial comment-- genetic make-up for increased PAI-1 expression protects against stroke.

Stroke 2003 Dec 20;34(12):2828-9. Epub 2003 Nov 20.

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http://dx.doi.org/10.1161/01.STR.0000103831.56586.4FDOI Listing
December 2003

Factor V Leiden mutation accelerates the onset of natural menopause.

Menopause 2003 Sep-Oct;10(5):477-81

Julius Center for Health Sciences and Primary Care, University Medical Center, Utrecht, The Netherlands.

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http://dx.doi.org/10.1097/01.GME.0000056040.51813.1ADOI Listing
December 2003

Heterozygosity for the Cys282Tyr mutation in the HFE gene and the risk of colorectal cancer (Netherlands).

Cancer Causes Control 2003 Aug;14(6):541-5

Julius Center for Health Sciences and Primary Care, University Medical Center, Utrecht, The Netherlands.

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http://dx.doi.org/10.1023/a:1024839528684DOI Listing
August 2003

No modifying effect of NAT1, GSTM1, and GSTT1 on the relation between smoking and colorectal cancer risk.

Cancer Epidemiol Biomarkers Prev 2003 Jul;12(7):681-2

Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, 3508 GA Utrecht, the Netherlands.

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July 2003

Factor V Leiden in central venous catheter-associated thrombosis.

Br J Haematol 2002 Jul;118(1):267-70

Department of Haematology, University Medical Center Utrecht (UMCU), Utrecht, The Netherlands.

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http://dx.doi.org/10.1046/j.1365-2141.2002.03591.xDOI Listing
July 2002

Quality and quantity of DNA isolated from frozen urine in population-based research.

Anal Biochem 2002 May;304(2):206-11

Julius Center for General Practice and Patient Oriented Research, University Medical Center, 3508 GA Utrecht, The Netherlands.

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http://dx.doi.org/10.1006/abio.2002.5634DOI Listing
May 2002