Publications by authors named "Mark R Cookson"

100Publications

Can Leucine-Rich Repeat Kinase 2 Inhibition Benefit GBA-Parkinson's Disease?

Mov Disord 2020 05;35(5):721-723

Cell Biology and Gene Expression Section, National Institute on Aging, National Institutes of Health, Bethesda, Maryland, USA.

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http://dx.doi.org/10.1002/mds.28029DOI Listing
May 2020

Pathways of protein synthesis and degradation in PD pathogenesis.

Prog Brain Res 2020 10;252:217-270. Epub 2020 Feb 10.

Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Bethesda, MD, United States. Electronic address:

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http://dx.doi.org/10.1016/bs.pbr.2020.01.002DOI Listing
February 2020

Correction to: Molecular mechanism of olesoxime-mediated neuroprotection through targeting α-synuclein interaction with mitochondrial VDAC.

Cell Mol Life Sci 2020 09;77(18):3691-3692

Section on Molecular Transport, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, 9000 Rockville Pike, Bldg. 29B, Room 1G09, Bethesda, MD, 20892-0924, USA.

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http://dx.doi.org/10.1007/s00018-019-03417-6DOI Listing
September 2020

Molecular mechanism of olesoxime-mediated neuroprotection through targeting α-synuclein interaction with mitochondrial VDAC.

Cell Mol Life Sci 2020 Sep 23;77(18):3611-3626. Epub 2019 Nov 23.

Section on Molecular Transport, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, 9000 Rockville Pike, Bldg. 29B, Room 1G09, Bethesda, MD, 20892-0924, USA.

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http://dx.doi.org/10.1007/s00018-019-03386-wDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7244372PMC
September 2020

Proteomics: techniques and applications in neuroscience.

Authors:
Mark R Cookson

J Neurochem 2019 11 17;151(4):394-396. Epub 2019 Oct 17.

Laboratory of Neurogenetics, Cell Biology and Gene Expression Section, National Institute on Aging, Bethesda, Maryland, USA.

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http://dx.doi.org/10.1111/jnc.14867DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6856389PMC
November 2019

DNAJC proteins and pathways to parkinsonism.

FEBS J 2019 08 20;286(16):3080-3094. Epub 2019 Jun 20.

School of Pharmacy, University of Reading, UK.

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http://dx.doi.org/10.1111/febs.14936DOI Listing
August 2019

The role of Rab GTPases in the pathobiology of Parkinson' disease.

Curr Opin Cell Biol 2019 08 1;59:73-80. Epub 2019 May 1.

Cell Biology and Gene Expression Section, Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Bethesda, MD 20892, USA. Electronic address:

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http://dx.doi.org/10.1016/j.ceb.2019.03.009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6726541PMC
August 2019

Proteomics; applications in familial Parkinson's disease.

J Neurochem 2019 11 9;151(4):446-458. Epub 2019 Jul 9.

Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Bethesda, Maryland, USA.

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http://dx.doi.org/10.1111/jnc.14708DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6814454PMC
November 2019

Glial phagocytic clearance in Parkinson's disease.

Mol Neurodegener 2019 04 5;14(1):16. Epub 2019 Apr 5.

Department of Biology, University of Padova, Via Ugo Bassi 58/B, 35131, Padova, Italy.

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http://dx.doi.org/10.1186/s13024-019-0314-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6451240PMC
April 2019

LRRK2 links genetic and sporadic Parkinson's disease.

Biochem Soc Trans 2019 04 5;47(2):651-661. Epub 2019 Mar 5.

Cell Biology and Gene Expression Section, Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Bldg. 35, 35 Convent Drive, Bethesda, MD 20892-3707, U.S.A.

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http://dx.doi.org/10.1042/BST20180462DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6563926PMC
April 2019

Assessment of APOE in atypical parkinsonism syndromes.

Neurobiol Dis 2019 07 21;127:142-146. Epub 2019 Feb 21.

Neurodegenerative Diseases Research Unit, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, USA; Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD, USA. Electronic address:

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http://dx.doi.org/10.1016/j.nbd.2019.02.016DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6588472PMC
July 2019

The endocytic membrane trafficking pathway plays a major role in the risk of Parkinson's disease.

Mov Disord 2019 04 24;34(4):460-468. Epub 2019 Jan 24.

Molecular Genetics Section, Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Bethesda, Maryland, USA.

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http://dx.doi.org/10.1002/mds.27614DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6467788PMC
April 2019

Genetic analysis of neurodegenerative diseases in a pathology cohort.

Neurobiol Aging 2019 04 17;76:214.e1-214.e9. Epub 2018 Nov 17.

Neurodegenerative Diseases Research Unit, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, USA; Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD, USA. Electronic address:

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http://dx.doi.org/10.1016/j.neurobiolaging.2018.11.007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6391207PMC
April 2019

The role of monogenic genes in idiopathic Parkinson's disease.

Neurobiol Dis 2019 04 15;124:230-239. Epub 2018 Nov 15.

Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Bethesda, MD, USA. Electronic address:

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http://dx.doi.org/10.1016/j.nbd.2018.11.012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6363864PMC
April 2019

Converging pathways in neurodegeneration, from genetics to mechanisms.

Nat Neurosci 2018 10 26;21(10):1300-1309. Epub 2018 Sep 26.

Departments of Neurology, Neurobiology, and Cell Biology, and the Duke Center for Neurodegeneration & Neurotherapeutics, Duke University School of Medicine, Durham, NC, USA.

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http://www.nature.com/articles/s41593-018-0237-7
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http://dx.doi.org/10.1038/s41593-018-0237-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6278826PMC
October 2018

Reduction of PINK1 or DJ-1 impair mitochondrial motility in neurites and alter ER-mitochondria contacts.

J Cell Mol Med 2018 11 22;22(11):5439-5449. Epub 2018 Aug 22.

Division of Neurogeriatrics, Department of Neurobiology, Care Sciences and Society, Center for Alzheimer Research, Karolinska Institutet, Stockholm, Sweden.

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http://dx.doi.org/10.1111/jcmm.13815DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6201361PMC
November 2018

Analysis of macroautophagy related proteins in G2019S LRRK2 Parkinson's disease brains with Lewy body pathology.

Brain Res 2018 12 25;1701:75-84. Epub 2018 Jul 25.

Reta Lila Weston Institute of Neurological Studies, UCL Institute of Neurology, 1 Wakefield Street, London WC1N 1PJ, United Kingdom; Department of Clinical and Movement Neuroscience, UCL Institute of Neurology, WC1N 3BG, United Kingdom. Electronic address:

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http://dx.doi.org/10.1016/j.brainres.2018.07.023DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6361106PMC
December 2018

Detection of endogenous S1292 LRRK2 autophosphorylation in mouse tissue as a readout for kinase activity.

NPJ Parkinsons Dis 2018 19;4:13. Epub 2018 Apr 19.

1Cell Biology and Gene Expression Section, Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Bethesda, MD USA.

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http://dx.doi.org/10.1038/s41531-018-0049-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5908918PMC
April 2018

The Endosomal-Lysosomal Pathway Is Dysregulated by Expression .

Front Neurosci 2017 12;11:702. Epub 2017 Dec 12.

Department of Pathology and Cell Biology, Taub Institute for Research of Alzheimer's Disease and the Aging Brain, Columbia University Medical Center, Colombia University, New York, NY, United States.

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http://dx.doi.org/10.3389/fnins.2017.00702DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5733017PMC
December 2017

The LRRK2 signalling system.

Cell Tissue Res 2018 Jul 8;373(1):39-50. Epub 2018 Jan 8.

School of Pharmacy, University of Reading, Whiteknights, Reading, RG6 6AP, UK.

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http://dx.doi.org/10.1007/s00441-017-2759-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6015615PMC
July 2018

Transcriptomic profiling of the human brain reveals that altered synaptic gene expression is associated with chronological aging.

Sci Rep 2017 12 4;7(1):16890. Epub 2017 Dec 4.

Cell Biology and Gene Expression Section, Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Bethesda, MD, USA.

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http://dx.doi.org/10.1038/s41598-017-17322-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5715102PMC
December 2017

LRRK2 phosphorylates membrane-bound Rabs and is activated by GTP-bound Rab7L1 to promote recruitment to the trans-Golgi network.

Hum Mol Genet 2018 01;27(2):385-395

Department of Neurology, Center for Neurodegeneration and Experimental Therapeutics, University of Alabama at Birmingham, Birmingham, AL 35233 USA.

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http://dx.doi.org/10.1093/hmg/ddx410DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5886198PMC
January 2018

Hexokinases link DJ-1 to the PINK1/parkin pathway.

Mol Neurodegener 2017 09 29;12(1):70. Epub 2017 Sep 29.

Cell Biology and Gene Expression Section, Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Building 35, Room 1A116, 35 Convent Drive, MSC 3707, Bethesda, MD, 20892-3707, USA.

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http://dx.doi.org/10.1186/s13024-017-0212-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5622528PMC
September 2017

LRRK2 promotes the activation of NLRC4 inflammasome during Typhimurium infection.

J Exp Med 2017 Oct 18;214(10):3051-3066. Epub 2017 Aug 18.

Shanghai Institute of Immunology, Shanghai Jiao Tong University School of Medicine, Shanghai, China

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http://dx.doi.org/10.1084/jem.20170014DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5626397PMC
October 2017

Alpha-synuclein triggers T-cell response. Is Parkinson's disease an autoimmune disorder?

Mov Disord 2017 09 7;32(9):1327. Epub 2017 Aug 7.

Cell Biology Section, Laboratory of Neurogenetics, NIA, NIH, Bethesda, Maryland, USA.

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http://dx.doi.org/10.1002/mds.27116DOI Listing
September 2017

The DYT6 Dystonia Protein THAP1 Regulates Myelination within the Oligodendrocyte Lineage.

Dev Cell 2017 07;42(1):52-67.e4

Department of Neurology, University of Michigan Medical School, 109 Zina Pitcher Place, Ann Arbor, MI 48109, USA; Department of Cell and Developmental Biology, University of Michigan Medical School, 109 Zina Pitcher Place, Ann Arbor, MI 48109, USA; VAAAHS, University of Michigan Medical School, University of Michigan, 109 Zina Pitcher Place, Ann Arbor, MI 48109, USA. Electronic address:

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http://dx.doi.org/10.1016/j.devcel.2017.06.009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5847273PMC
July 2017

Gene Linkage and Systems Biology.

Authors:
Mark R Cookson

Adv Neurobiol 2017 ;15:479-489

Laboratory of Neurogenetics, NIA, NIH. 35, Convent Drive, Bethesda, MD, 20892-3707, USA.

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http://dx.doi.org/10.1007/978-3-319-57193-5_19DOI Listing
November 2018

Mechanisms of Mutant LRRK2 Neurodegeneration.

Authors:
Mark R Cookson

Adv Neurobiol 2017 ;14:227-239

Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Room 1A116, 35 Convent Drive, Bethesda, MD, 20892-3707, USA.

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http://dx.doi.org/10.1007/978-3-319-49969-7_12DOI Listing
September 2018

The G2385R risk factor for Parkinson's disease enhances CHIP-dependent intracellular degradation of LRRK2.

Biochem J 2017 04 24;474(9):1547-1558. Epub 2017 Apr 24.

Cell Biology and Gene Expression Section, Laboratory of Neurogenetics, National Institute on Aging, NIH, 35 Convent Drive, Room 1A-116, Bethesda, MD 20892-3707, U.S.A.

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http://dx.doi.org/10.1042/BCJ20160909DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6178381PMC
April 2017

Novel genetic loci associated with hippocampal volume.

Authors:
Derrek P Hibar Hieab H H Adams Neda Jahanshad Ganesh Chauhan Jason L Stein Edith Hofer Miguel E Renteria Joshua C Bis Alejandro Arias-Vasquez M Kamran Ikram Sylvane Desrivières Meike W Vernooij Lucija Abramovic Saud Alhusaini Najaf Amin Micael Andersson Konstantinos Arfanakis Benjamin S Aribisala Nicola J Armstrong Lavinia Athanasiu Tomas Axelsson Ashley H Beecham Alexa Beiser Manon Bernard Susan H Blanton Marc M Bohlken Marco P Boks Janita Bralten Adam M Brickman Owen Carmichael M Mallar Chakravarty Qiang Chen Christopher R K Ching Vincent Chouraki Gabriel Cuellar-Partida Fabrice Crivello Anouk Den Braber Nhat Trung Doan Stefan Ehrlich Sudheer Giddaluru Aaron L Goldman Rebecca F Gottesman Oliver Grimm Michael E Griswold Tulio Guadalupe Boris A Gutman Johanna Hass Unn K Haukvik David Hoehn Avram J Holmes Martine Hoogman Deborah Janowitz Tianye Jia Kjetil N Jørgensen Nazanin Karbalai Dalia Kasperaviciute Sungeun Kim Marieke Klein Bernd Kraemer Phil H Lee David C M Liewald Lorna M Lopez Michelle Luciano Christine Macare Andre F Marquand Mar Matarin Karen A Mather Manuel Mattheisen David R McKay Yuri Milaneschi Susana Muñoz Maniega Kwangsik Nho Allison C Nugent Paul Nyquist Loes M Olde Loohuis Jaap Oosterlaan Martina Papmeyer Lukas Pirpamer Benno Pütz Adaikalavan Ramasamy Jennifer S Richards Shannon L Risacher Roberto Roiz-Santiañez Nanda Rommelse Stefan Ropele Emma J Rose Natalie A Royle Tatjana Rundek Philipp G Sämann Arvin Saremi Claudia L Satizabal Lianne Schmaal Andrew J Schork Li Shen Jean Shin Elena Shumskaya Albert V Smith Emma Sprooten Lachlan T Strike Alexander Teumer Diana Tordesillas-Gutierrez Roberto Toro Daniah Trabzuni Stella Trompet Dhananjay Vaidya Jeroen Van der Grond Sven J Van der Lee Dennis Van der Meer Marjolein M J Van Donkelaar Kristel R Van Eijk Theo G M Van Erp Daan Van Rooij Esther Walton Lars T Westlye Christopher D Whelan Beverly G Windham Anderson M Winkler Katharina Wittfeld Girma Woldehawariat Christiane Wolf Thomas Wolfers Lisa R Yanek Jingyun Yang Alex Zijdenbos Marcel P Zwiers Ingrid Agartz Laura Almasy David Ames Philippe Amouyel Ole A Andreassen Sampath Arepalli Amelia A Assareh Sandra Barral Mark E Bastin Diane M Becker James T Becker David A Bennett John Blangero Hans van Bokhoven Dorret I Boomsma Henry Brodaty Rachel M Brouwer Han G Brunner Randy L Buckner Jan K Buitelaar Kazima B Bulayeva Wiepke Cahn Vince D Calhoun Dara M Cannon Gianpiero L Cavalleri Ching-Yu Cheng Sven Cichon Mark R Cookson Aiden Corvin Benedicto Crespo-Facorro Joanne E Curran Michael Czisch Anders M Dale Gareth E Davies Anton J M De Craen Eco J C De Geus Philip L De Jager Greig I De Zubicaray Ian J Deary Stéphanie Debette Charles DeCarli Norman Delanty Chantal Depondt Anita DeStefano Allissa Dillman Srdjan Djurovic Gary Donohoe Wayne C Drevets Ravi Duggirala Thomas D Dyer Christian Enzinger Susanne Erk Thomas Espeseth Iryna O Fedko Guillén Fernández Luigi Ferrucci Simon E Fisher Debra A Fleischman Ian Ford Myriam Fornage Tatiana M Foroud Peter T Fox Clyde Francks Masaki Fukunaga J Raphael Gibbs David C Glahn Randy L Gollub Harald H H Göring Robert C Green Oliver Gruber Vilmundur Gudnason Sebastian Guelfi Asta K Håberg Narelle K Hansell John Hardy Catharina A Hartman Ryota Hashimoto Katrin Hegenscheid Andreas Heinz Stephanie Le Hellard Dena G Hernandez Dirk J Heslenfeld Beng-Choon Ho Pieter J Hoekstra Wolfgang Hoffmann Albert Hofman Florian Holsboer Georg Homuth Norbert Hosten Jouke-Jan Hottenga Matthew Huentelman Hilleke E Hulshoff Pol Masashi Ikeda Clifford R Jack Mark Jenkinson Robert Johnson Erik G Jönsson J Wouter Jukema René S Kahn Ryota Kanai Iwona Kloszewska David S Knopman Peter Kochunov John B Kwok Stephen M Lawrie Hervé Lemaître Xinmin Liu Dan L Longo Oscar L Lopez Simon Lovestone Oliver Martinez Jean-Luc Martinot Venkata S Mattay Colm McDonald Andrew M McIntosh Francis J McMahon Katie L McMahon Patrizia Mecocci Ingrid Melle Andreas Meyer-Lindenberg Sebastian Mohnke Grant W Montgomery Derek W Morris Thomas H Mosley Thomas W Mühleisen Bertram Müller-Myhsok Michael A Nalls Matthias Nauck Thomas E Nichols Wiro J Niessen Markus M Nöthen Lars Nyberg Kazutaka Ohi Rene L Olvera Roel A Ophoff Massimo Pandolfo Tomas Paus Zdenka Pausova Brenda W J H Penninx G Bruce Pike Steven G Potkin Bruce M Psaty Simone Reppermund Marcella Rietschel Joshua L Roffman Nina Romanczuk-Seiferth Jerome I Rotter Mina Ryten Ralph L Sacco Perminder S Sachdev Andrew J Saykin Reinhold Schmidt Helena Schmidt Peter R Schofield Sigurdur Sigursson Andrew Simmons Andrew Singleton Sanjay M Sisodiya Colin Smith Jordan W Smoller Hilkka Soininen Vidar M Steen David J Stott Jessika E Sussmann Anbupalam Thalamuthu Arthur W Toga Bryan J Traynor Juan Troncoso Magda Tsolaki Christophe Tzourio Andre G Uitterlinden Maria C Valdés Hernández Marcel Van der Brug Aad van der Lugt Nic J A van der Wee Neeltje E M Van Haren Dennis van 't Ent Marie-Jose Van Tol Badri N Vardarajan Bruno Vellas Dick J Veltman Henry Völzke Henrik Walter Joanna M Wardlaw Thomas H Wassink Michael E Weale Daniel R Weinberger Michael W Weiner Wei Wen Eric Westman Tonya White Tien Y Wong Clinton B Wright Ronald H Zielke Alan B Zonderman Nicholas G Martin Cornelia M Van Duijn Margaret J Wright W T Longstreth Gunter Schumann Hans J Grabe Barbara Franke Lenore J Launer Sarah E Medland Sudha Seshadri Paul M Thompson M Arfan Ikram

Nat Commun 2017 01 18;8:13624. Epub 2017 Jan 18.

Department of Epidemiology, Erasmus University Medical Center, 3015 CE Rotterdam, The Netherlands.

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http://dx.doi.org/10.1038/ncomms13624DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5253632PMC
January 2017

Major Shifts in Glial Regional Identity Are a Transcriptional Hallmark of Human Brain Aging.

Cell Rep 2017 01;18(2):557-570

Institute of Neurology, University College London, London WC1N 3BG, UK; The Francis Crick Institute, 1 Midland Road, London NW1 1AT, UK. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2016.12.011DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5263238PMC
January 2017

LRRK2 at the interface of autophagosomes, endosomes and lysosomes.

Mol Neurodegener 2016 12 7;11(1):73. Epub 2016 Dec 7.

Cell Biology and Gene Expression Section, Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Bldg. 35, 35 Convent Drive, Bethesda, MD, 20892-3707, USA.

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http://molecularneurodegeneration.biomedcentral.com/articles
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http://dx.doi.org/10.1186/s13024-016-0140-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5142374PMC
December 2016

Cellular functions of LRRK2 implicate vesicular trafficking pathways in Parkinson's disease.

Authors:
Mark R Cookson

Biochem Soc Trans 2016 12;44(6):1603-1610

Cell Biology and Gene Expression Section, Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Building 35, Room 1A116, MSC3707, 35, Convent Drive, Bethesda, MD 20892-3707, USA.

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http://dx.doi.org/10.1042/BST20160228DOI Listing
December 2016

The impact of fraudulent and irreproducible data to the translational research crisis - solutions and implementation.

J Neurochem 2016 10;139 Suppl 2:253-270

Department of Neurology, University Hospital, RWTH Aachen, Aachen, Germany.

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http://doi.wiley.com/10.1111/jnc.13844
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http://dx.doi.org/10.1111/jnc.13844DOI Listing
October 2016

Novel genetic loci underlying human intracranial volume identified through genome-wide association.

Authors:
Hieab H H Adams Derrek P Hibar Vincent Chouraki Jason L Stein Paul A Nyquist Miguel E Rentería Stella Trompet Alejandro Arias-Vasquez Sudha Seshadri Sylvane Desrivières Ashley H Beecham Neda Jahanshad Katharina Wittfeld Sven J Van der Lee Lucija Abramovic Saud Alhusaini Najaf Amin Micael Andersson Konstantinos Arfanakis Benjamin S Aribisala Nicola J Armstrong Lavinia Athanasiu Tomas Axelsson Alexa Beiser Manon Bernard Joshua C Bis Laura M E Blanken Susan H Blanton Marc M Bohlken Marco P Boks Janita Bralten Adam M Brickman Owen Carmichael M Mallar Chakravarty Ganesh Chauhan Qiang Chen Christopher R K Ching Gabriel Cuellar-Partida Anouk Den Braber Nhat Trung Doan Stefan Ehrlich Irina Filippi Tian Ge Sudheer Giddaluru Aaron L Goldman Rebecca F Gottesman Corina U Greven Oliver Grimm Michael E Griswold Tulio Guadalupe Johanna Hass Unn K Haukvik Saima Hilal Edith Hofer David Hoehn Avram J Holmes Martine Hoogman Deborah Janowitz Tianye Jia Dalia Kasperaviciute Sungeun Kim Marieke Klein Bernd Kraemer Phil H Lee Jiemin Liao David C M Liewald Lorna M Lopez Michelle Luciano Christine Macare Andre Marquand Mar Matarin Karen A Mather Manuel Mattheisen Bernard Mazoyer David R McKay Rebekah McWhirter Yuri Milaneschi Nazanin Mirza-Schreiber Ryan L Muetzel Susana Muñoz Maniega Kwangsik Nho Allison C Nugent Loes M Olde Loohuis Jaap Oosterlaan Martina Papmeyer Irene Pappa Lukas Pirpamer Sara Pudas Benno Pütz Kumar B Rajan Adaikalavan Ramasamy Jennifer S Richards Shannon L Risacher Roberto Roiz-Santiañez Nanda Rommelse Emma J Rose Natalie A Royle Tatjana Rundek Philipp G Sämann Claudia L Satizabal Lianne Schmaal Andrew J Schork Li Shen Jean Shin Elena Shumskaya Albert V Smith Emma Sprooten Lachlan T Strike Alexander Teumer Russell Thomson Diana Tordesillas-Gutierrez Roberto Toro Daniah Trabzuni Dhananjay Vaidya Jeroen Van der Grond Dennis Van der Meer Marjolein M J Van Donkelaar Kristel R Van Eijk Theo G M Van Erp Daan Van Rooij Esther Walton Lars T Westlye Christopher D Whelan Beverly G Windham Anderson M Winkler Girma Woldehawariat Christiane Wolf Thomas Wolfers Bing Xu Lisa R Yanek Jingyun Yang Alex Zijdenbos Marcel P Zwiers Ingrid Agartz Neelum T Aggarwal Laura Almasy David Ames Philippe Amouyel Ole A Andreassen Sampath Arepalli Amelia A Assareh Sandra Barral Mark E Bastin Diane M Becker James T Becker David A Bennett John Blangero Hans van Bokhoven Dorret I Boomsma Henry Brodaty Rachel M Brouwer Han G Brunner Randy L Buckner Jan K Buitelaar Kazima B Bulayeva Wiepke Cahn Vince D Calhoun Dara M Cannon Gianpiero L Cavalleri Christopher Chen Ching-Yu Cheng Sven Cichon Mark R Cookson Aiden Corvin Benedicto Crespo-Facorro Joanne E Curran Michael Czisch Anders M Dale Gareth E Davies Eco J C De Geus Philip L De Jager Greig I de Zubicaray Norman Delanty Chantal Depondt Anita L DeStefano Allissa Dillman Srdjan Djurovic Gary Donohoe Wayne C Drevets Ravi Duggirala Thomas D Dyer Susanne Erk Thomas Espeseth Denis A Evans Iryna O Fedko Guillén Fernández Luigi Ferrucci Simon E Fisher Debra A Fleischman Ian Ford Tatiana M Foroud Peter T Fox Clyde Francks Masaki Fukunaga J Raphael Gibbs David C Glahn Randy L Gollub Harald H H Göring Hans J Grabe Robert C Green Oliver Gruber Vilmundur Gudnason Sebastian Guelfi Narelle K Hansell John Hardy Catharina A Hartman Ryota Hashimoto Katrin Hegenscheid Andreas Heinz Stephanie Le Hellard Dena G Hernandez Dirk J Heslenfeld Beng-Choon Ho Pieter J Hoekstra Wolfgang Hoffmann Albert Hofman Florian Holsboer Georg Homuth Norbert Hosten Jouke-Jan Hottenga Hilleke E Hulshoff Pol Masashi Ikeda M Kamran Ikram Clifford R Jack Mark Jenkinson Robert Johnson Erik G Jönsson J Wouter Jukema René S Kahn Ryota Kanai Iwona Kloszewska David S Knopman Peter Kochunov John B Kwok Stephen M Lawrie Hervé Lemaître Xinmin Liu Dan L Longo W T Longstreth Oscar L Lopez Simon Lovestone Oliver Martinez Jean-Luc Martinot Venkata S Mattay Colm McDonald Andrew M McIntosh Katie L McMahon Francis J McMahon Patrizia Mecocci Ingrid Melle Andreas Meyer-Lindenberg Sebastian Mohnke Grant W Montgomery Derek W Morris Thomas H Mosley Thomas W Mühleisen Bertram Müller-Myhsok Michael A Nalls Matthias Nauck Thomas E Nichols Wiro J Niessen Markus M Nöthen Lars Nyberg Kazutaka Ohi Rene L Olvera Roel A Ophoff Massimo Pandolfo Tomas Paus Zdenka Pausova Brenda W J H Penninx G Bruce Pike Steven G Potkin Bruce M Psaty Simone Reppermund Marcella Rietschel Joshua L Roffman Nina Romanczuk-Seiferth Jerome I Rotter Mina Ryten Ralph L Sacco Perminder S Sachdev Andrew J Saykin Reinhold Schmidt Peter R Schofield Sigurdur Sigurdsson Andy Simmons Andrew Singleton Sanjay M Sisodiya Colin Smith Jordan W Smoller Hilkka Soininen Velandai Srikanth Vidar M Steen David J Stott Jessika E Sussmann Anbupalam Thalamuthu Henning Tiemeier Arthur W Toga Bryan J Traynor Juan Troncoso Jessica A Turner Christophe Tzourio Andre G Uitterlinden Maria C Valdés Hernández Marcel Van der Brug Aad Van der Lugt Nic J A Van der Wee Cornelia M Van Duijn Neeltje E M Van Haren Dennis Van T Ent Marie-Jose Van Tol Badri N Vardarajan Dick J Veltman Meike W Vernooij Henry Völzke Henrik Walter Joanna M Wardlaw Thomas H Wassink Michael E Weale Daniel R Weinberger Michael W Weiner Wei Wen Eric Westman Tonya White Tien Y Wong Clinton B Wright H Ronald Zielke Alan B Zonderman Ian J Deary Charles DeCarli Helena Schmidt Nicholas G Martin Anton J M De Craen Margaret J Wright Lenore J Launer Gunter Schumann Myriam Fornage Barbara Franke Stéphanie Debette Sarah E Medland M Arfan Ikram Paul M Thompson

Nat Neurosci 2016 12 3;19(12):1569-1582. Epub 2016 Oct 3.

Imaging Genetics Center, USC Mark and Mary Stevens Neuroimaging and Informatics Institute, Keck School of Medicine of University of Southern California, Los Angeles, California, USA.

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December 2016

RNA-binding proteins implicated in neurodegenerative diseases.

Authors:
Mark R Cookson

Wiley Interdiscip Rev RNA 2017 01 23;8(1). Epub 2016 Sep 23.

Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Bethesda, MD, USA.

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January 2017

Caspase-1 causes truncation and aggregation of the Parkinson's disease-associated protein α-synuclein.

Proc Natl Acad Sci U S A 2016 08 1;113(34):9587-92. Epub 2016 Aug 1.

Department of Biochemistry and Molecular Biology, Indiana University School of Medicine, Indianapolis, IN 46202; Stark Neurosciences Research Institute, Indiana University School of Medicine, Indianapolis, IN 46202; Department of Neurology, Indiana University School of Medicine, Indianapolis, IN 46202

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August 2016

Structure, function, and leucine-rich repeat kinase 2: On the importance of reproducibility in understanding Parkinson's disease.

Authors:
Mark R Cookson

Proc Natl Acad Sci U S A 2016 07 15;113(30):8346-8. Epub 2016 Jul 15.

Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Bethesda, MD 20892

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http://dx.doi.org/10.1073/pnas.1609311113DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4968709PMC
July 2016

Identification of bona-fide LRRK2 kinase substrates.

Mov Disord 2016 08 29;31(8):1140-1. Epub 2016 Apr 29.

Cell Biology and Gene Expression Section, Laboratory of Neurogenetics, National Institute on Aging, Bethesda, Maryland, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4981516PMC
August 2016

The Effects of Variants in the Parkin, PINK1, and DJ-1 Genes along with Evidence for their Pathogenicity.

Curr Protein Pept Sci 2017 ;18(7):702-714

Cell Biology and Gene Expression Section, NIA, Building 35, Room 1A116, 5 Convent Drive, MSC 3707, Bethesda, MD 20892-3707, United States.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5140758PMC
November 2017

The function of orthologues of the human Parkinson's disease gene LRRK2 across species: implications for disease modelling in preclinical research.

Biochem J 2016 Feb;473(3):221-32

Cell Biology and Gene Expression Section, Laboratory of Neurogenetics, NIA, NIH, Bethesda, MD 20892, U.S.A.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5165698PMC
February 2016

ADAR2 affects mRNA coding sequence edits with only modest effects on gene expression or splicing in vivo.

RNA Biol 2016 ;13(1):15-24

b Department of Neuroscience , Karolinska Institute , 171 77 Stockholm , Sweden.

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http://dx.doi.org/10.1080/15476286.2015.1110675DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4829308PMC
October 2016

The Polg Mutator Phenotype Does Not Cause Dopaminergic Neurodegeneration in DJ-1-Deficient Mice.

eNeuro 2015 Jan-Feb;2(1). Epub 2015 Mar 23.

Cell Biology and Gene Expression Section, Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health , Bethesda, Maryland 20892.

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http://dx.doi.org/10.1523/ENEURO.0075-14.2015DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4586922PMC
October 2015

Genes associated with Parkinson's disease: regulation of autophagy and beyond.

J Neurochem 2016 10 3;139 Suppl 1:91-107. Epub 2015 Sep 3.

Cell Biology and Gene Expression Section, Laboratory of Neurogenetics, National Institute on Aging, Bethesda, Maryland, USA.

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http://dx.doi.org/10.1111/jnc.13266DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5834228PMC
October 2016

Pathways to Parkinsonism Redux: convergent pathobiological mechanisms in genetics of Parkinson's disease.

Hum Mol Genet 2015 Oct 22;24(R1):R32-44. Epub 2015 Jun 22.

Cell Biology and Gene Expression Section, Laboratory of Neurogenetics, National Institute on Aging, 35 Convent Drive, Bethesda, MD 20892-3707, USA

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http://dx.doi.org/10.1093/hmg/ddv236DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4571999PMC
October 2015

LRRK2 Pathways Leading to Neurodegeneration.

Authors:
Mark R Cookson

Curr Neurol Neurosci Rep 2015 Jul;15(7):42

Cell Biology and Gene Expression Section, Laboratory of Neurogenetics, National Institute on Aging, 35 Convent Drive, Bethesda, MD, 20892-3707, USA,

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5839465PMC
July 2015

Common genetic variants influence human subcortical brain structures.

Authors:
Derrek P Hibar Jason L Stein Miguel E Renteria Alejandro Arias-Vasquez Sylvane Desrivières Neda Jahanshad Roberto Toro Katharina Wittfeld Lucija Abramovic Micael Andersson Benjamin S Aribisala Nicola J Armstrong Manon Bernard Marc M Bohlken Marco P Boks Janita Bralten Andrew A Brown M Mallar Chakravarty Qiang Chen Christopher R K Ching Gabriel Cuellar-Partida Anouk den Braber Sudheer Giddaluru Aaron L Goldman Oliver Grimm Tulio Guadalupe Johanna Hass Girma Woldehawariat Avram J Holmes Martine Hoogman Deborah Janowitz Tianye Jia Sungeun Kim Marieke Klein Bernd Kraemer Phil H Lee Loes M Olde Loohuis Michelle Luciano Christine Macare Karen A Mather Manuel Mattheisen Yuri Milaneschi Kwangsik Nho Martina Papmeyer Adaikalavan Ramasamy Shannon L Risacher Roberto Roiz-Santiañez Emma J Rose Alireza Salami Philipp G Sämann Lianne Schmaal Andrew J Schork Jean Shin Lachlan T Strike Alexander Teumer Marjolein M J van Donkelaar Kristel R van Eijk Raymond K Walters Lars T Westlye Christopher D Whelan Anderson M Winkler Marcel P Zwiers Saud Alhusaini Lavinia Athanasiu Stefan Ehrlich Marina M H Hakobjan Cecilie B Hartberg Unn K Haukvik Angelien J G A M Heister David Hoehn Dalia Kasperaviciute David C M Liewald Lorna M Lopez Remco R R Makkinje Mar Matarin Marlies A M Naber D Reese McKay Margaret Needham Allison C Nugent Benno Pütz Natalie A Royle Li Shen Emma Sprooten Daniah Trabzuni Saskia S L van der Marel Kimm J E van Hulzen Esther Walton Christiane Wolf Laura Almasy David Ames Sampath Arepalli Amelia A Assareh Mark E Bastin Henry Brodaty Kazima B Bulayeva Melanie A Carless Sven Cichon Aiden Corvin Joanne E Curran Michael Czisch Greig I de Zubicaray Allissa Dillman Ravi Duggirala Thomas D Dyer Susanne Erk Iryna O Fedko Luigi Ferrucci Tatiana M Foroud Peter T Fox Masaki Fukunaga J Raphael Gibbs Harald H H Göring Robert C Green Sebastian Guelfi Narelle K Hansell Catharina A Hartman Katrin Hegenscheid Andreas Heinz Dena G Hernandez Dirk J Heslenfeld Pieter J Hoekstra Florian Holsboer Georg Homuth Jouke-Jan Hottenga Masashi Ikeda Clifford R Jack Mark Jenkinson Robert Johnson Ryota Kanai Maria Keil Jack W Kent Peter Kochunov John B Kwok Stephen M Lawrie Xinmin Liu Dan L Longo Katie L McMahon Eva Meisenzahl Ingrid Melle Sebastian Mohnke Grant W Montgomery Jeanette C Mostert Thomas W Mühleisen Michael A Nalls Thomas E Nichols Lars G Nilsson Markus M Nöthen Kazutaka Ohi Rene L Olvera Rocio Perez-Iglesias G Bruce Pike Steven G Potkin Ivar Reinvang Simone Reppermund Marcella Rietschel Nina Romanczuk-Seiferth Glenn D Rosen Dan Rujescu Knut Schnell Peter R Schofield Colin Smith Vidar M Steen Jessika E Sussmann Anbupalam Thalamuthu Arthur W Toga Bryan J Traynor Juan Troncoso Jessica A Turner Maria C Valdés Hernández Dennis van 't Ent Marcel van der Brug Nic J A van der Wee Marie-Jose van Tol Dick J Veltman Thomas H Wassink Eric Westman Ronald H Zielke Alan B Zonderman David G Ashbrook Reinmar Hager Lu Lu Francis J McMahon Derek W Morris Robert W Williams Han G Brunner Randy L Buckner Jan K Buitelaar Wiepke Cahn Vince D Calhoun Gianpiero L Cavalleri Benedicto Crespo-Facorro Anders M Dale Gareth E Davies Norman Delanty Chantal Depondt Srdjan Djurovic Wayne C Drevets Thomas Espeseth Randy L Gollub Beng-Choon Ho Wolfgang Hoffmann Norbert Hosten René S Kahn Stephanie Le Hellard Andreas Meyer-Lindenberg Bertram Müller-Myhsok Matthias Nauck Lars Nyberg Massimo Pandolfo Brenda W J H Penninx Joshua L Roffman Sanjay M Sisodiya Jordan W Smoller Hans van Bokhoven Neeltje E M van Haren Henry Völzke Henrik Walter Michael W Weiner Wei Wen Tonya White Ingrid Agartz Ole A Andreassen John Blangero Dorret I Boomsma Rachel M Brouwer Dara M Cannon Mark R Cookson Eco J C de Geus Ian J Deary Gary Donohoe Guillén Fernández Simon E Fisher Clyde Francks David C Glahn Hans J Grabe Oliver Gruber John Hardy Ryota Hashimoto Hilleke E Hulshoff Pol Erik G Jönsson Iwona Kloszewska Simon Lovestone Venkata S Mattay Patrizia Mecocci Colm McDonald Andrew M McIntosh Roel A Ophoff Tomas Paus Zdenka Pausova Mina Ryten Perminder S Sachdev Andrew J Saykin Andy Simmons Andrew Singleton Hilkka Soininen Joanna M Wardlaw Michael E Weale Daniel R Weinberger Hieab H H Adams Lenore J Launer Stephan Seiler Reinhold Schmidt Ganesh Chauhan Claudia L Satizabal James T Becker Lisa Yanek Sven J van der Lee Maritza Ebling Bruce Fischl W T Longstreth Douglas Greve Helena Schmidt Paul Nyquist Louis N Vinke Cornelia M van Duijn Luting Xue Bernard Mazoyer Joshua C Bis Vilmundur Gudnason Sudha Seshadri M Arfan Ikram Nicholas G Martin Margaret J Wright Gunter Schumann Barbara Franke Paul M Thompson Sarah E Medland

Nature 2015 Apr 21;520(7546):224-9. Epub 2015 Jan 21.

QIMR Berghofer Medical Research Institute, Brisbane 4006, Australia.

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April 2015

Phosphorylation of LRRK2 by casein kinase 1α regulates trans-Golgi clustering via differential interaction with ARHGEF7.

Nat Commun 2014 Dec 15;5:5827. Epub 2014 Dec 15.

Cell Biology and Gene Expression Section, Laboratory of Neurogenetics, National Institute on Aging, 35 Convent Drive, Bethesda, Maryland 20892-3707, USA.

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December 2014

Transcriptomic changes in brain development.

Int Rev Neurobiol 2014 ;116:233-50

Cell Biology and Gene Expression Section, Laboratory of Neurogenetics, National Institute on Aging, Bethesda, Maryland, USA. Electronic address:

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May 2015

Lardy brains make Parkinson's disease mice worse.

Authors:
Mark R Cookson

J Neurochem 2014 Dec 20;131(6):697-8. Epub 2014 Aug 20.

Cell Biology and Gene Expression Section, Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Bethesda, Maryland, USA.

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December 2014

Heterogeneity of leucine-rich repeat kinase 2 mutations: genetics, mechanisms and therapeutic implications.

Neurotherapeutics 2014 Oct;11(4):738-50

Cell Biology and Gene Expression Section, Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Bethesda, MD, 20892, USA.

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October 2014

Arsenite stress down-regulates phosphorylation and 14-3-3 binding of leucine-rich repeat kinase 2 (LRRK2), promoting self-association and cellular redistribution.

J Biol Chem 2014 Aug 18;289(31):21386-400. Epub 2014 Jun 18.

From the Reta Lila Weston Institute of Neurological Studies, University College London Institute of Neurology, London WC1N 1PJ, United Kingdom, the Department of Molecular Neuroscience, University College London Institute of Neurology, London WC1N 3BJ, United Kingdom,

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August 2014

Use of cysteine-reactive cross-linkers to probe conformational flexibility of human DJ-1 demonstrates that Glu18 mutations are dimers.

J Neurochem 2014 Sep 19;130(6):839-53. Epub 2014 Jun 19.

Department of Biochemistry and the Redox Biology Center, University of Nebraska, Lincoln, Nebraska, USA.

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September 2014

Downregulation of Pink1 influences mitochondrial fusion-fission machinery and sensitizes to neurotoxins in dopaminergic cells.

Neurotoxicology 2014 Sep 2;44:140-8. Epub 2014 May 2.

Grupos de Neurociencias y Muerte Celular, Facultad de Medicina e Instituto de Genética, Universidad Nacional de Colombia, Bogotá, Colombia. Electronic address:

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September 2014

Post-translational decrease in respiratory chain proteins in the Polg mutator mouse brain.

PLoS One 2014 10;9(4):e94646. Epub 2014 Apr 10.

Cell Biology and Gene Expression Section, Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Bethesda, Maryland, United States of America.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3983222PMC
June 2015

LRRK2: dropping (kinase) inhibitions and seeking an (immune) response.

J Neurochem 2014 Jun 24;129(6):895-7. Epub 2014 Mar 24.

Cell Biology and Gene Expression Section, Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Bethesda, Maryland, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4055502PMC
June 2014

Parkinson disease-associated mutation R1441H in LRRK2 prolongs the "active state" of its GTPase domain.

Proc Natl Acad Sci U S A 2014 Mar 3;111(11):4055-60. Epub 2014 Mar 3.

Department of Biochemistry and Molecular Biology and Stark Neurosciences Institute, Indiana University School of Medicine, Indianapolis, IN 46202.

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http://dx.doi.org/10.1073/pnas.1323285111DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3964117PMC
March 2014

Unbiased screen for interactors of leucine-rich repeat kinase 2 supports a common pathway for sporadic and familial Parkinson disease.

Proc Natl Acad Sci U S A 2014 Feb 7;111(7):2626-31. Epub 2014 Feb 7.

Cell Biology and Gene Expression Section, Computational Biology Core, Laboratory of Neurogenetics, and Molecular Genetics Section, National Institute on Aging/National Institutes of Health, Bethesda, MD 20892.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3932908PMC
February 2014

Mutant LRRK2 toxicity in neurons depends on LRRK2 levels and synuclein but not kinase activity or inclusion bodies.

J Neurosci 2014 Jan;34(2):418-33

Gladstone Institute of Neurological Disease, the Taube-Koret Center for Neurodegenerative Disease Research, and the Hellman Family Foundation Program in Alzheimer's Disease Research, San Francisco, California 94158, Departments of Neurology, Physiology, and Graduate Programs in Neuroscience and Biomedical Sciences, University of California, San Francisco, California 94158, and Laboratory of Neurogenetics, National Institutes of Health, Bethesda, Maryland 20892.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3870929PMC
January 2014

Age-associated miRNA alterations in skeletal muscle from rhesus monkeys reversed by caloric restriction.

Aging (Albany NY) 2013 Sep;5(9):692-703

Experimental Gerontology Section, Translational Gerontology Branch, National Institute on Aging, National Institutes of Health, Baltimore, MD 21224, USA.

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http://dx.doi.org/10.18632/aging.100598DOI Listing
September 2013

Hexokinase activity is required for recruitment of parkin to depolarized mitochondria.

Hum Mol Genet 2014 Jan 19;23(1):145-56. Epub 2013 Aug 19.

Cell Biology and Gene Expression Section and.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3857951PMC
January 2014

Identification of protein phosphatase 1 as a regulator of the LRRK2 phosphorylation cycle.

Biochem J 2013 Nov;456(1):119-28

*Laboratory for Neurobiology and Gene Therapy, Department of Neurosciences, KU Leuven, Kapucijnenvoer 33, 3000 Leuven, Belgium.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5141581PMC
November 2013

Lysosomal impairment in Parkinson's disease.

Mov Disord 2013 Jun 11;28(6):725-32. Epub 2013 Apr 11.

Institute of Neurodegenerative Diseases, University of Bordeaux Segalen, Centre National de Recherche Scientifique Unité Mixte de Recherche 5293, Bordeaux, France.

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June 2013

mRNA expression, splicing and editing in the embryonic and adult mouse cerebral cortex.

Nat Neurosci 2013 Apr 17;16(4):499-506. Epub 2013 Feb 17.

Cell Biology and Gene Expression Section, Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Bethesda, Maryland, USA.

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April 2013

Age-associated changes in gene expression in human brain and isolated neurons.

Neurobiol Aging 2013 Apr 21;34(4):1199-209. Epub 2012 Nov 21.

Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Bethesda, MD 20892-3707, USA.

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April 2013

Cell population-specific expression analysis of human cerebellum.

BMC Genomics 2012 Nov 12;13:610. Epub 2012 Nov 12.

Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Bethesda, MD, USA.

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November 2012

Cellular effects of LRRK2 mutations.

Authors:
Mark R Cookson

Biochem Soc Trans 2012 Oct;40(5):1070-3

Cell Biology and Gene Expression Unit, Laboratory of Neurogenetics, National Institute on Aging, 35 Convent Drive, Bethesda, MD 20892-3707, USA.

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October 2012