Publications by authors named "Mark P Mattson"

100Publications

Age-related impairment of cerebral blood flow response to K channel opener in Alzheimer's disease mice with presenilin-1 mutation.

J Cereb Blood Flow Metab 2020 Nov 17:271678X20964233. Epub 2020 Nov 17.

Laboratory of Neurosciences, National Institute on Aging Intramural Research Program, Baltimore, MD, USA.

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http://dx.doi.org/10.1177/0271678X20964233DOI Listing
November 2020

Preface.

Int Rev Neurobiol 2020 ;155:xiii-xviii

Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, MD, United States.

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http://dx.doi.org/10.1016/S0074-7742(20)30134-3DOI Listing
January 2020

Hormesis: A potential strategic approach to the treatment of neurodegenerative disease.

Int Rev Neurobiol 2020 11;155:271-301. Epub 2020 Aug 11.

Departments of Neurology & Biochemistry, Georgetown University Medical Center, Washington, DC, United States.

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http://dx.doi.org/10.1016/bs.irn.2020.03.024DOI Listing
August 2020

Preface.

Int Rev Neurobiol 2020 ;154:xv-xx

Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, MD, United States.

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http://dx.doi.org/10.1016/S0074-7742(20)30115-XDOI Listing
January 2020

Involvement of GABAergic interneuron dysfunction and neuronal network hyperexcitability in Alzheimer's disease: Amelioration by metabolic switching.

Authors:
Mark P Mattson

Int Rev Neurobiol 2020 10;154:191-205. Epub 2020 Jul 10.

Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, MD, United States. Electronic address:

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http://dx.doi.org/10.1016/bs.irn.2020.01.006DOI Listing
July 2020

Astrocyte- and Neuron-Derived Extracellular Vesicles from Alzheimer's Disease Patients Effect Complement-Mediated Neurotoxicity.

Cells 2020 07 4;9(7). Epub 2020 Jul 4.

Laboratory of Clinical Investigation, Intramural Research Program, National Institute on Aging, National Institutes of Health (NIA/NIH), Baltimore, MD 21224, USA.

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http://dx.doi.org/10.3390/cells9071618DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7407141PMC
July 2020

Publisher Correction: Intermittent metabolic switching, neuroplasticity and brain health.

Nat Rev Neurosci 2020 Aug;21(8):445

Laboratory of Neurosciences, National Institute on Aging Intramural Research Program, Baltimore, Maryland, 21224, USA.

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http://dx.doi.org/10.1038/s41583-020-0342-yDOI Listing
August 2020

Effects of Intermittent Fasting on Health, Aging, and Disease. Reply.

N Engl J Med 2020 04;382(18):1773-1774

National Institute on Aging, Baltimore, MD.

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http://dx.doi.org/10.1056/NEJMc2001176DOI Listing
April 2020

Apolipoprotein E and oxidative stress in brain with relevance to Alzheimer's disease.

Neurobiol Dis 2020 05 6;138:104795. Epub 2020 Feb 6.

Department of Neuroscience, Johns Hopkins University, Baltimore, MD 21205, USA.

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http://dx.doi.org/10.1016/j.nbd.2020.104795DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7085980PMC
May 2020

Effects of Intermittent Fasting on Health, Aging, and Disease.

N Engl J Med 2019 12;381(26):2541-2551

From the Translational Gerontology Branch (R.C.) and the Laboratory of Neurosciences (M.P.M.), Intramural Research Program, National Institute on Aging, National Institutes of Health, and the Department of Neuroscience, Johns Hopkins University School of Medicine (M.P.M.) - both in Baltimore.

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http://dx.doi.org/10.1056/NEJMra1905136DOI Listing
December 2019

Medium Chain Triglycerides induce mild ketosis and may improve cognition in Alzheimer's disease. A systematic review and meta-analysis of human studies.

Ageing Res Rev 2020 03 20;58:101001. Epub 2019 Dec 20.

Laboratory of Clinical Investigation, Intramural Research Program, National Institute on Aging, National Institutes of Health, Baltimore, USA. Electronic address:

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http://dx.doi.org/10.1016/j.arr.2019.101001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7050425PMC
March 2020

SIRT3 Haploinsufficiency Aggravates Loss of GABAergic Interneurons and Neuronal Network Hyperexcitability in an Alzheimer's Disease Model.

J Neurosci 2020 01 9;40(3):694-709. Epub 2019 Dec 9.

Laboratory of Neurosciences, National Institute on Aging Intramural Research Program, National Institutes of Health, Baltimore, Maryland 21224,

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http://dx.doi.org/10.1523/JNEUROSCI.1446-19.2019DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6961992PMC
January 2020

A mitochondrial uncoupler prodrug protects dopaminergic neurons and improves functional outcome in a mouse model of Parkinson's disease.

Neurobiol Aging 2020 01 26;85:123-130. Epub 2019 Sep 26.

Laboratory of Neurosciences, National Institute on Aging Intramural Research Program, Baltimore, MD, USA; Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, MD, USA. Electronic address:

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http://dx.doi.org/10.1016/j.neurobiolaging.2019.09.011DOI Listing
January 2020

NAD in Brain Aging and Neurodegenerative Disorders.

Cell Metab 2019 10;30(4):630-655

Department of Clinical Molecular Biology, University of Oslo and Akershus University Hospital, 1478 Lørenskog, Norway; The Norwegian Centre on Healthy Ageing (NO-Age), Oslo, Norway. Electronic address:

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http://dx.doi.org/10.1016/j.cmet.2019.09.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6787556PMC
October 2019

A Pilot Study of Exenatide Actions in Alzheimer's Disease.

Curr Alzheimer Res 2019 ;16(8):741-752

Laboratory of Neurosciences, National Institute on Aging/National Institutes of Health (NIA/NIH), 3001 S. Hanover St, NM531, Baltimore, MD, 21225, United States.

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http://dx.doi.org/10.2174/1567205016666190913155950DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7476877PMC
October 2020

Intergenerational Metabolic Syndrome and Neuronal Network Hyperexcitability in Autism.

Trends Neurosci 2019 10 5;42(10):709-726. Epub 2019 Sep 5.

Laboratory of Neurosciences, National Institute on Aging Intramural Research Program, Baltimore, MD, USA; Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, MD, USA. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S01662236193013
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http://dx.doi.org/10.1016/j.tins.2019.08.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6779523PMC
October 2019

Incretin Mimetics as Rational Candidates for the Treatment of Traumatic Brain Injury.

ACS Pharmacol Transl Sci 2019 Apr 11;2(2):66-91. Epub 2019 Feb 11.

Translational Gerontology Branch, Intramural Research Program, National Institute on Aging, National Institutes of Health, Baltimore, MD 21224, USA.

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http://dx.doi.org/10.1021/acsptsci.9b00003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6687335PMC
April 2019

A Novel Apolipoprotein E Antagonist Functionally Blocks Apolipoprotein E Interaction With N-terminal Amyloid Precursor Protein, Reduces β-Amyloid-Associated Pathology, and Improves Cognition.

Biol Psychiatry 2019 08 2;86(3):208-220. Epub 2019 May 2.

Department of Psychiatry and Behavioral Neurosciences, Morsani College of Medicine, University of South Florida, Tampa, Florida. Electronic address:

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http://dx.doi.org/10.1016/j.biopsych.2019.04.026DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6642011PMC
August 2019

Sideroflexin 3 is a Mitochondrial Protein Enriched in Neurons.

Neuromolecular Med 2019 09 8;21(3):314-321. Epub 2019 Jun 8.

Laboratory of Neurosciences, NIA/NIH Biomedical Research Center, 251 Bayview Boulevard, Baltimore, MD, 21224, USA.

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http://dx.doi.org/10.1007/s12017-019-08553-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6689427PMC
September 2019

Chronic Mild Gut Inflammation Accelerates Brain Neuropathology and Motor Dysfunction in α-Synuclein Mutant Mice.

Neuromolecular Med 2019 09 11;21(3):239-249. Epub 2019 May 11.

Laboratory of Neurosciences, National Institute on Aging Intramural Research Program, Baltimore, MD, 21224, USA.

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http://dx.doi.org/10.1007/s12017-019-08539-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6701950PMC
September 2019

Curcumin and hormesis with particular emphasis on neural cells.

Food Chem Toxicol 2019 Jul 30;129:399-404. Epub 2019 Apr 30.

Department of Molecular Biology and Genetics, Aarhus University, Gustav Wieds Vej 10C, DK, 8000, Aarhus, Denmark. Electronic address:

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http://dx.doi.org/10.1016/j.fct.2019.04.053DOI Listing
July 2019

Sonic hedgehog expression in the postnatal brain.

Biol Open 2019 Mar 26;8(3). Epub 2019 Mar 26.

Laboratory of Neurosciences, NIA/NIH, Baltimore, MD 21224, USA

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http://dx.doi.org/10.1242/bio.040592DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6451348PMC
March 2019

Assessment of NADmetabolism in human cell cultures, erythrocytes, cerebrospinal fluid and primate skeletal muscle.

Anal Biochem 2019 05 27;572:1-8. Epub 2019 Feb 27.

Biomedical Research Center, National Institute on Aging, National Institutes of Health, Baltimore, MD, USA. Electronic address:

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http://dx.doi.org/10.1016/j.ab.2019.02.019DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6685425PMC
May 2019

An Evolutionary Perspective on Why Food Overconsumption Impairs Cognition.

Authors:
Mark P Mattson

Trends Cogn Sci 2019 03 19;23(3):200-212. Epub 2019 Jan 19.

Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA; Laboratory of Neurosciences, National Institute on Aging Intramural Research Program, Baltimore, MD 21224, USA. Electronic address:

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http://dx.doi.org/10.1016/j.tics.2019.01.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6412136PMC
March 2019

Uric acid enhances longevity and endurance and protects the brain against ischemia.

Neurobiol Aging 2019 03 12;75:159-168. Epub 2018 Dec 12.

Laboratory of Neurosciences, National Institute on Aging, Intramural Research Program, Baltimore, MD, USA; Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, MD, USA. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S01974580183043
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http://dx.doi.org/10.1016/j.neurobiolaging.2018.10.031DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6410356PMC
March 2019

Calcium dysregulation mediates mitochondrial and neurite outgrowth abnormalities in SOD2 deficient embryonic cerebral cortical neurons.

Cell Death Differ 2019 09 2;26(9):1600-1614. Epub 2018 Nov 2.

Laboratory of Neurosciences, Biomedical Research Center, National Institute on Aging Intramural Research Program, 251 Bayview Blvd, Baltimore, MD, 21224, USA.

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http://www.nature.com/articles/s41418-018-0230-4
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http://dx.doi.org/10.1038/s41418-018-0230-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6748124PMC
September 2019

Hydroxyurea attenuates oxidative, metabolic, and excitotoxic stress in rat hippocampal neurons and improves spatial memory in a mouse model of Alzheimer's disease.

Neurobiol Aging 2018 12 29;72:121-133. Epub 2018 Aug 29.

Laboratory of Neurosciences, National Institute on Aging Intramural Research Program, Baltimore, MD, USA. Electronic address:

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http://dx.doi.org/10.1016/j.neurobiolaging.2018.08.021DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6215724PMC
December 2018

Brain regional synchronous activity predicts tauopathy in 3×TgAD mice.

Neurobiol Aging 2018 10 21;70:160-169. Epub 2018 Jun 21.

Laboratory of Neurosciences, National Institute on Aging Intramural Research Program, Baltimore, MD, USA; Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore MD, USA. Electronic address:

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http://dx.doi.org/10.1016/j.neurobiolaging.2018.06.016DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6196326PMC
October 2018

Hallmarks of Brain Aging: Adaptive and Pathological Modification by Metabolic States.

Cell Metab 2018 Jun;27(6):1176-1199

Department of Physiology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore; School of Pharmacy, Sungkyunkwan University, Suwon 16419, Republic of Korea.

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http://dx.doi.org/10.1016/j.cmet.2018.05.011DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6039826PMC
June 2018

Invaginating Structures in Mammalian Synapses.

Front Synaptic Neurosci 2018 5;10. Epub 2018 Apr 5.

Laboratory of Neurosciences, National Institute on Aging, Intramural Research Program, Baltimore, MD, United States.

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http://dx.doi.org/10.3389/fnsyn.2018.00004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5895750PMC
April 2018

Notch signaling and neuronal death in stroke.

Prog Neurobiol 2018 Jun - Aug;165-167:103-116. Epub 2018 Mar 21.

School of Pharmacy, Sungkyunkwan University, Suwon 16419, Republic of Korea. Electronic address:

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http://dx.doi.org/10.1016/j.pneurobio.2018.03.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6100747PMC
February 2019

Deficiency of Toll-like receptors 2, 3 or 4 extends life expectancy in Huntington's disease mice.

Heliyon 2018 Jan 18;4(1):e00508. Epub 2018 Jan 18.

The Mina and Everard Goodman Faculty of Life Sciences, Bar-Ilan University, Ramat-Gan, Israel.

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http://dx.doi.org/10.1016/j.heliyon.2018.e00508DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5857515PMC
January 2018

Activity-dependent neuronal Klotho enhances astrocytic aerobic glycolysis.

J Cereb Blood Flow Metab 2019 08 1;39(8):1544-1556. Epub 2018 Mar 1.

2 Laboratory of Neurosciences, National Institute on Aging Intramural Research Program, Baltimore, MD, USA.

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http://dx.doi.org/10.1177/0271678X18762700DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6681535PMC
August 2019

Impact of Coffee and Cacao Purine Metabolites on Neuroplasticity and Neurodegenerative Disease.

Neurochem Res 2019 Jan 8;44(1):214-227. Epub 2018 Feb 8.

Laboratory of Neurosciences, National Institute on Aging Intramural Research Program, Baltimore, MD, USA.

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http://dx.doi.org/10.1007/s11064-018-2492-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6082740PMC
January 2019

Intermittent metabolic switching, neuroplasticity and brain health.

Nat Rev Neurosci 2018 02 11;19(2):63-80. Epub 2018 Jan 11.

Laboratory of Neurosciences, National Institute on Aging Intramural Research Program, Baltimore, Maryland 21224, USA.

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http://dx.doi.org/10.1038/nrn.2017.156DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5913738PMC
February 2018

Flipping the Metabolic Switch: Understanding and Applying the Health Benefits of Fasting.

Obesity (Silver Spring) 2018 02 31;26(2):254-268. Epub 2017 Oct 31.

Laboratory of Neurosciences, National Institute on Aging Intramural Research Program, Baltimore, Maryland, USA.

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http://dx.doi.org/10.1002/oby.22065DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5783752PMC
February 2018

Intercellular transfer of pathogenic α-synuclein by extracellular vesicles is induced by the lipid peroxidation product 4-hydroxynonenal.

Neurobiol Aging 2018 01 22;61:52-65. Epub 2017 Sep 22.

Laboratory of Neurosciences, National Institute on Aging Intramural Research Program, BRC 5C214, Baltimore, MD, USA; Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, MD, USA. Electronic address:

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http://dx.doi.org/10.1016/j.neurobiolaging.2017.09.016DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5705257PMC
January 2018

How does hormesis impact biology, toxicology, and medicine?

NPJ Aging Mech Dis 2017 15;3:13. Epub 2017 Sep 15.

Laboratory of Neurosciences, National Institute on Aging Intramural Research Program, Baltimore, MD 21224 USA.

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http://dx.doi.org/10.1038/s41514-017-0013-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5601424PMC
September 2017

NAD in Aging: Molecular Mechanisms and Translational Implications.

Trends Mol Med 2017 10 9;23(10):899-916. Epub 2017 Sep 9.

Laboratory of Molecular Gerontology, National Institute on Aging, National Institutes of Health, Baltimore, MD 21224, USA; Danish Center for Healthy Aging, University of Copenhagen, Blegdamsvej 3B, 2200 Copenhagen, Denmark. Electronic address:

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http://dx.doi.org/10.1016/j.molmed.2017.08.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7494058PMC
October 2017

Purine Biosynthesis Enzymes in Hippocampal Neurons.

Neuromolecular Med 2017 Dec 2;19(4):518-524. Epub 2017 Sep 2.

Laboratory of Neurosciences, NIA/NIH, Baltimore, MD, 21224, USA.

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http://dx.doi.org/10.1007/s12017-017-8466-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6085884PMC
December 2017

Age-associated alterations in the levels of cytotoxic lipid molecular species and oxidative stress in the murine thymus are reduced by growth hormone treatment.

Mech Ageing Dev 2017 10 1;167:46-55. Epub 2017 Sep 1.

Laboratory of Immunology, National Institute on Aging Intramural Research Program, National Institutes of Health, Baltimore, MD, 21224-6825, USA; Center for Translational Studies, Medical Service, VA Medical Center-DC, Washington DC, 20422, USA. Electronic address:

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http://dx.doi.org/10.1016/j.mad.2017.08.015DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5819751PMC
October 2017

Walking speed decline in older adults is associated with elevated pro-BDNF in plasma extracellular vesicles.

Exp Gerontol 2017 11 23;98:209-216. Epub 2017 Aug 23.

Laboratory of Neurosciences, National Institute on Aging on Intramural Research Program, Baltimore, MD 21224, United States. Electronic address:

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http://dx.doi.org/10.1016/j.exger.2017.08.024DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5642035PMC
November 2017

Invaginating Presynaptic Terminals in Neuromuscular Junctions, Photoreceptor Terminals, and Other Synapses of Animals.

Neuromolecular Med 2017 Sep 13;19(2-3):193-240. Epub 2017 Jun 13.

Laboratory of Neurosciences, NIA/NIH, Baltimore, MD, 21224, USA.

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http://dx.doi.org/10.1007/s12017-017-8445-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6518423PMC
September 2017

Toll-like receptor 4 mediates fat, sugar, and umami taste preference and food intake and body weight regulation.

Obesity (Silver Spring) 2017 07 12;25(7):1237-1245. Epub 2017 May 12.

Laboratory of Neurosciences, National Institute on Aging, Intramural Research Program, Baltimore, Maryland, USA.

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http://dx.doi.org/10.1002/oby.21871DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5487280PMC
July 2017

skn-1 is required for interneuron sensory integration and foraging behavior in Caenorhabditis elegans.

PLoS One 2017 1;12(5):e0176798. Epub 2017 May 1.

Laboratory of Neurosciences, National Institute on Aging, Intramural Research Program, Baltimore, Maryland, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0176798PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5411085PMC
September 2017

Brain metabolism in health, aging, and neurodegeneration.

EMBO J 2017 06 24;36(11):1474-1492. Epub 2017 Apr 24.

Laboratory of Neuroscience, National Institute on Aging, Baltimore, MD, USA

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http://dx.doi.org/10.15252/embj.201695810DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5452017PMC
June 2017

Exercise and BDNF reduce Aβ production by enhancing α-secretase processing of APP.

J Neurochem 2017 07 18;142(2):286-296. Epub 2017 May 18.

Laboratory of Neurosciences, National Institute on Aging Intramural Research Program, National Institutes of Health, Baltimore, Maryland, USA.

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http://dx.doi.org/10.1111/jnc.14034DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5498234PMC
July 2017

Mitophagy and Alzheimer's Disease: Cellular and Molecular Mechanisms.

Trends Neurosci 2017 03 9;40(3):151-166. Epub 2017 Feb 9.

Laboratory of Molecular Gerontology, National Institute on Aging, National Institutes of Health, Baltimore, MD 21224, USA. Electronic address:

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http://dx.doi.org/10.1016/j.tins.2017.01.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5341618PMC
March 2017

Effects of a dietary ketone ester on hippocampal glycolytic and tricarboxylic acid cycle intermediates and amino acids in a 3xTgAD mouse model of Alzheimer's disease.

J Neurochem 2017 04 15;141(2):195-207. Epub 2017 Mar 15.

Laboratory of Metabolic Control, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, Maryland, USA.

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http://dx.doi.org/10.1111/jnc.13958DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5383517PMC
April 2017

Early involvement of lysosome dysfunction in the degeneration of cerebral cortical neurons caused by the lipid peroxidation product 4-hydroxynonenal.

J Neurochem 2017 03 16;140(6):941-954. Epub 2017 Feb 16.

Laboratory of Neurosciences, National Institute on Aging Intramural Research Program, Baltimore, Maryland, USA.

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http://dx.doi.org/10.1111/jnc.13957DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5339057PMC
March 2017

Sonic hedgehog pathway activation increases mitochondrial abundance and activity in hippocampal neurons.

Mol Biol Cell 2017 Feb 8;28(3):387-395. Epub 2016 Dec 8.

Laboratory of Neurosciences, National Institute on Aging, National Institutes of Health, Baltimore, MD 21224.

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http://dx.doi.org/10.1091/mbc.E16-07-0553DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5341723PMC
February 2017

Extracellular Vesicle-Associated Aβ Mediates Trans-Neuronal Bioenergetic and Ca-Handling Deficits in Alzheimer's Disease Models.

NPJ Aging Mech Dis 2016 22;2. Epub 2016 Sep 22.

Laboratory of Neurosciences, National Institute on Aging, NIH, Baltimore, Maryland 21224.; Department of Neuroscience, Johns Hopkins University School of Medicine, 725 N. Wolfe Street, Baltimore, MD 21205.

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http://dx.doi.org/10.1038/npjamd.2016.19DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5137253PMC
September 2016

Adaptive responses of neuronal mitochondria to bioenergetic challenges: Roles in neuroplasticity and disease resistance.

Free Radic Biol Med 2017 01 29;102:203-216. Epub 2016 Nov 29.

Laboratory of Neurosciences, National Institute on Aging, Baltimore, MD 21224, United States; Department of Neuroscience, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, United States. Electronic address:

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http://dx.doi.org/10.1016/j.freeradbiomed.2016.11.045DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5209274PMC
January 2017

Sonic Hedgehog Signaling and Hippocampal Neuroplasticity.

Trends Neurosci 2016 12 16;39(12):840-850. Epub 2016 Nov 16.

Laboratory of Neurosciences, National Institute on Aging, Intramural Research Program, Baltimore, MD 21224, USA; Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA. Electronic address:

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http://dx.doi.org/10.1016/j.tins.2016.10.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5148655PMC
December 2016

Impact of intermittent fasting on health and disease processes.

Ageing Res Rev 2017 Oct 31;39:46-58. Epub 2016 Oct 31.

Genesis Breast Cancer Prevention Centre, University Hospital South Manchester, Wythenshaw, M23 9LT Manchester, United Kingdom.

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http://dx.doi.org/10.1016/j.arr.2016.10.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5411330PMC
October 2017

The astrocytic transporter SLC7A10 (Asc-1) mediates glycinergic inhibition of spinal cord motor neurons.

Sci Rep 2016 10 19;6:35592. Epub 2016 Oct 19.

Department of Neurology, Johns Hopkins School of Medicine, 855 N. Wolfe Street, Baltimore, Maryland, 21205, USA.

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http://dx.doi.org/10.1038/srep35592DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5069678PMC
October 2016

3-Hydroxybutyrate regulates energy metabolism and induces BDNF expression in cerebral cortical neurons.

J Neurochem 2016 12 14;139(5):769-781. Epub 2016 Nov 14.

Laboratory of Neurosciences, National Institute on Aging Intramural Research Program, Baltimore, Maryland, USA.

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http://dx.doi.org/10.1111/jnc.13868DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5123937PMC
December 2016

DNA polymerase β decrement triggers death of olfactory bulb cells and impairs olfaction in a mouse model of Alzheimer's disease.

Aging Cell 2017 Feb 30;16(1):162-172. Epub 2016 Sep 30.

Laboratory of Molecular Gerontology, National Institute on Aging Intramural Research Program, Biomedical Research Center, 251 Bayview Blvd, Baltimore, MD, 21224, USA.

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http://dx.doi.org/10.1111/acel.12541DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5242308PMC
February 2017

Adenosine receptors as markers of brain iron deficiency: Implications for Restless Legs Syndrome.

Neuropharmacology 2016 12 4;111:160-168. Epub 2016 Sep 4.

Integrative Neurobiology Section, National Institute on Drug Abuse, Intramural Research Program, National Institutes of Health, Baltimore, MD 21224, USA. Electronic address:

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5056844PMC
http://dx.doi.org/10.1016/j.neuropharm.2016.09.002DOI Listing
December 2016

DNP, mitochondrial uncoupling, and neuroprotection: A little dab'll do ya.

Alzheimers Dement 2017 May 4;13(5):582-591. Epub 2016 Sep 4.

Laboratory of Neurosciences, National Institute on Aging Intramural Research Program, Baltimore, MD, USA; Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, MD, USA. Electronic address:

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http://dx.doi.org/10.1016/j.jalz.2016.08.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5337177PMC
May 2017

A randomized pilot study comparing zero-calorie alternate-day fasting to daily caloric restriction in adults with obesity.

Obesity (Silver Spring) 2016 09;24(9):1874-83

Department of Medicine, Division of Endocrinology, Metabolism, and Diabetes, University of Colorado Anschutz Medical Campus, Aurora, Colorado, USA.

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http://dx.doi.org/10.1002/oby.21581DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5042570PMC
September 2016

The long and the short of TRF2 in neurogenesis.

Cell Cycle 2016 Nov 26;15(22):3026-3032. Epub 2016 Aug 26.

a Laboratory of Genetics, National Institute on Aging, National Institutes of Health , Baltimore , MD , USA.

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http://dx.doi.org/10.1080/15384101.2016.1222339DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5134711PMC
November 2016

Probing extracellular Sonic hedgehog in neurons.

Biol Open 2016 Aug 15;5(8):1086-92. Epub 2016 Aug 15.

Laboratory of Neurosciences, National Institute on Aging Intramural Research Program, Baltimore, MD 21224, USA

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http://dx.doi.org/10.1242/bio.019422DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5004615PMC
August 2016

Nutritional strategies to optimise cognitive function in the aging brain.

Ageing Res Rev 2016 11 26;31:80-92. Epub 2016 Jun 26.

Charles Perkins Centre, University of Sydney, Sydney 2006 Australia; Aging and Alzheimers Institute, ANZAC Research Institute, Concord Clinical School/Sydney Medical School, Concord, 2139 Australia. Electronic address:

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http://dx.doi.org/10.1016/j.arr.2016.06.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5035589PMC
November 2016

Impact of lysosome status on extracellular vesicle content and release.

Ageing Res Rev 2016 12 26;32:65-74. Epub 2016 May 26.

Laboratory of Neurosciences, National Institute on Aging, Baltimore, MD 21224, USA.

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http://dx.doi.org/10.1016/j.arr.2016.05.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5154730PMC
December 2016

The Diversity of Spine Synapses in Animals.

Neuromolecular Med 2016 Dec 26;18(4):497-539. Epub 2016 May 26.

Laboratory of Neurosciences, National Institute on Aging Intramural Research Program, Baltimore, MD, 21224, USA.

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http://dx.doi.org/10.1007/s12017-016-8405-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5158183PMC
December 2016

Phytochemicals in Ischemic Stroke.

Neuromolecular Med 2016 Sep 18;18(3):283-305. Epub 2016 May 18.

Department of Physiology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, 117597, Singapore.

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http://dx.doi.org/10.1007/s12017-016-8403-0DOI Listing
September 2016

Corrigendum to "Combination therapy with lenalidomide and nanoceria ameliorates CNS autoimmunity", [Exp. Neurol. 273 (2015), 151-160].

Exp Neurol 2016 06 4;280:121. Epub 2016 Apr 4.

Laboratory of Neurosciences, National Institute on Aging Intramural Research Program, Baltimore, MD 21224, USA; Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA. Electronic address:

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http://dx.doi.org/10.1016/j.expneurol.2016.02.015DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5878012PMC
June 2016

Alternative Splicing of Neuronal Differentiation Factor TRF2 Regulated by HNRNPH1/H2.

Cell Rep 2016 05 21;15(5):926-934. Epub 2016 Apr 21.

Laboratory of Genetics, National Institute on Aging-Intramural Research Program, NIH, Baltimore, MD 21224, USA. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2016.03.080DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4856555PMC
May 2016

Lipid-laden cells differentially distributed in the aging brain are functionally active and correspond to distinct phenotypes.

Sci Rep 2016 Mar 31;6:23795. Epub 2016 Mar 31.

Laboratory of Immunophysiology, Institute of Biomedical Sciences, Health Sciences Center, Federal University of Rio de Janeiro, Av. Carlos Chagas Filho 373, Rio de Janeiro, RJ, Brazil, 21941-902.

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http://dx.doi.org/10.1038/srep23795DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4814830PMC
March 2016