Mark P Hedger

Mark P Hedger

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Mark P Hedger

Mark P Hedger

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Acute heat-treatment disrupts inhibin-related protein production and gene expression in the adult rat testis.

Mol Cell Endocrinol 2019 Aug 15;498:110546. Epub 2019 Aug 15.

Centre for Reproductive Health, Hudson Institute of Medical Research, Clayton, Victoria, Australia; Department of Molecular and Translational Sciences, Monash University, Clayton, Victoria, Australia.

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http://dx.doi.org/10.1016/j.mce.2019.110546DOI Listing
August 2019

Cumulin and FSH Cooperate to Regulate Inhibin B and Activin B Production by Human Granulosa-Lutein Cells In Vitro.

Endocrinology 2019 Apr;160(4):853-862

Fertility & Research Centre, School of Women's and Children's Health, University of New South Wales Sydney, Kensington, New South Wales, Australia.

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http://dx.doi.org/10.1210/en.2018-01026DOI Listing
April 2019

Activin over-expression in the testis of mice lacking the inhibin α-subunit gene is associated with androgen deficiency and regression of the male reproductive tract.

Mol Cell Endocrinol 2018 07 28;470:188-198. Epub 2017 Oct 28.

Hudson Institute of Medical Research, Clayton, Victoria, Australia; Department of Anatomy and Developmental Biology, Monash University, Clayton, Victoria, Australia.

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http://dx.doi.org/10.1016/j.mce.2017.10.013DOI Listing
July 2018

Epididymal cysteine-rich secretory proteins are required for epididymal sperm maturation and optimal sperm function.

Mol Hum Reprod 2018 03;24(3):111-122

The Development and Stem Cells Program of the Biomedicine Discovery Institute, and The Department of Anatomy and Developmental Biology, Monash University, Clayton, Victoria 3800, Australia.

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https://academic.oup.com/molehr/article/24/3/111/4816350
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http://dx.doi.org/10.1093/molehr/gay001DOI Listing
March 2018

Cytokines in Male Fertility and Reproductive Pathologies: Immunoregulation and Beyond.

Front Endocrinol (Lausanne) 2017 20;8:307. Epub 2017 Nov 20.

Department of Urology, Pediatric Urology and Andrology, Justus Liebig University Giessen, Giessen, Germany.

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http://dx.doi.org/10.3389/fendo.2017.00307DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5715375PMC
November 2017

Activin Biology After Lung Transplantation.

Transplant Direct 2017 Jun 11;3(6):e159. Epub 2017 May 11.

Department of Medicine, Monash University, Melbourne, Victoria, Australia.

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http://dx.doi.org/10.1097/TXD.0000000000000676DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5464778PMC
June 2017

Hyperglycemia is associated with reduced testicular function and activin dysregulation in the Ins2 mouse model of type 1 diabetes.

Mol Cell Endocrinol 2017 05 16;446:91-101. Epub 2017 Feb 16.

Clinical Research Unit, Centre of Internal Medicine, Justus-Liebig-University, Giessen, Germany.

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http://dx.doi.org/10.1016/j.mce.2017.02.020DOI Listing
May 2017

Uropathogenic Escherichia coli causes fibrotic remodelling of the epididymis.

J Pathol 2016 09;240(1):15-24

Institute of Anatomy and Cell Biology, Justus-Liebig-University Giessen, Germany.

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http://dx.doi.org/10.1002/path.4748DOI Listing
September 2016

Prepubertal Di-n-Butyl Phthalate Exposure Alters Sertoli and Leydig Cell Function and Lowers Bone Density in Adult Male Mice.

Endocrinology 2016 07 8;157(7):2595-603. Epub 2016 Apr 8.

Priority Research Centres for Reproductive Science and Chemical Biology, School of Environmental and Life Sciences (A.B., C.I.), and School of Mathematical and Physical Sciences (N.C.), Faculty of Science and Information Technology, University of Newcastle, Callaghan, New South Wales 2308, Australia; St Vincent's Institute of Medical Research (R.W.J., I.J.P., N.A.S.) and Department of Medicine at St. Vincent's Hospital (R.W.J., I.J.P., N.A.S.), The University of Melbourne, Fitzroy, Victoria 3065, Australia; Departments of Biochemistry and Molecular Biology (H.G., K.L.L.), Anatomy and Developmental Biology (S.C.M., K.L.L.), and Molecular Translational Sciences (K.L.L.), Monash University, and Hudson Institute of Medical Research (K.L.L., M.P.H.), Clayton, Victoria 3800, Australia; and Faculty of Science, Health, Education, and Engineering (C.I.), School of Health and Sport Sciences, University of the Sunshine Coast, Sippy Downs, Queensland 4556, Australia.

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http://dx.doi.org/10.1210/en.2015-1936DOI Listing
July 2016

Epididymitis: revelations at the convergence of clinical and basic sciences.

Asian J Androl 2015 Sep-Oct;17(5):756-63

Department of Anatomy and Cell Biology; Justus-Liebig-University of Giessen, 35385 Giessen, Germany.

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http://dx.doi.org/10.4103/1008-682X.155770DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4577585PMC
June 2016

The activin A antagonist follistatin inhibits cystic fibrosis-like lung inflammation and pathology.

Immunol Cell Biol 2015 Jul 10;93(6):567-74. Epub 2015 Mar 10.

1] Department of Allergy, Immunology & Respiratory Medicine, Central Clinical School, Monash University, Melbourne, Victoria, Australia [2] Department of Immunology, Central Clinical School, Monash University, Melbourne, Victoria, Australia [3] Department of Allergy, Immunology & Respiratory Medicine, The Alfred Hospital, Melbourne, Victoria, Australia.

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http://dx.doi.org/10.1038/icb.2015.7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4495664PMC
July 2015

Murine Inhibin α-Subunit Haploinsufficiency Causes Transient Abnormalities in Prepubertal Testis Development Followed by Adult Testicular Decline.

Endocrinology 2015 Jun 17;156(6):2254-68. Epub 2015 Mar 17.

Priority Research Centres for Reproductive Science (C.I., A.B., J.M., S.E.) and Chemical Biology (C.I.), School of Environmental and Life Sciences, Faculty of Science and Information Technology, University of Newcastle, Callaghan, New South Wales 2308, Australia; Departments of Anatomy and Developmental Biology (H.G., Q.L., K.L.L.) and Biochemistry and Molecular Biology (S.C.M., K.L.L.) and Monash Micro Imaging (A.J.F.), Monash University, Clayton, Victoria 3800, Australia; and Faculty of Medicine, Nursing, and Health Sciences (J.C.G.D.), Department of Medicine, Monash Medical Centre, and Monash Institute of Medical Research-Prince Henry's Institute of Medical Research (M.P.H.), Clayton, Victoria 3168, Australia.

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http://dx.doi.org/10.1210/en.2014-1555DOI Listing
June 2015

Simian immunodeficiency virus infection and immune responses in the pig-tailed macaque testis.

J Leukoc Biol 2015 Mar 20;97(3):599-609. Epub 2015 Jan 20.

*Department of Microbiology and Immunology, The University of Melbourne at the Peter Doherty Institute for Infection and Immunity, Victoria, Australia; Centre for Reproductive Health, Monash Institute of Medical Research-Prince Henry's Institute of Medical Research, Victoria, Australia; and Gynaecology Research Centre, Department of Obstetrics and Gynaecology, The University of Melbourne, Royal Women's Hospital, Parkville, Victoria, Australia.

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http://dx.doi.org/10.1189/jlb.4A0914-438RDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5477897PMC
March 2015

Regulation and actions of activin A and follistatin in myocardial ischaemia-reperfusion injury.

Cytokine 2014 Oct 19;69(2):255-62. Epub 2014 Jul 19.

Department of Surgery, Monash Medical Centre, Monash University, Clayton, Victoria 3168, Australia.

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http://dx.doi.org/10.1016/j.cyto.2014.06.017DOI Listing
October 2014

Serum activin A and B, and follistatin in critically ill patients with influenza A(H1N1) infection.

BMC Infect Dis 2014 May 10;14:253. Epub 2014 May 10.

Monash Institute of Medical Research, Monash University, Melbourne, Australia.

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http://dx.doi.org/10.1186/1471-2334-14-253DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4101860PMC
May 2014

Characterisation of macaque testicular leucocyte populations and T-lymphocyte immunity.

J Reprod Immunol 2013 Dec 27;100(2):146-56. Epub 2013 Sep 27.

Department of Microbiology and Immunology, University of Melbourne, Parkville, VIC Australia.

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http://dx.doi.org/10.1016/j.jri.2013.09.003DOI Listing
December 2013

Expression patterns of activin, inhibin and follistatin variants in the adult male mouse reproductive tract suggest important roles in the epididymis and vas deferens.

Reprod Fertil Dev 2013 ;25(3):570-80

Centre for Reproduction and Development, Monash Institute of Medical Research, Monash University, Clayton, Vic. 3168, Australia.

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http://dx.doi.org/10.1071/RD11287DOI Listing
September 2013

Correlation between blood activin levels and clinical parameters of type 2 diabetes.

Exp Diabetes Res 2012 16;2012:410579. Epub 2012 Dec 16.

Monash Institute of Medical Research, Monash University, Clayton, VIC 3168, Australia.

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http://dx.doi.org/10.1155/2012/410579DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3533484PMC
May 2013

Phenotypic and functional heterogeneity of the testicular macrophage population: a new regulatory model.

J Reprod Immunol 2013 Apr 13;97(2):147-58. Epub 2013 Feb 13.

Department of Microbiology and Immunology, University of Melbourne, Parkville, VIC, Australia.

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http://dx.doi.org/10.1016/j.jri.2013.01.001DOI Listing
April 2013

Regulation of activin A release from murine bone marrow-derived neutrophil precursors by tumour necrosis factor-α and insulin.

Cytokine 2013 Jan 30;61(1):199-204. Epub 2012 Oct 30.

Monash Institute of Medical Research, Monash University, Clayton, Victoria, Australia.

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http://dx.doi.org/10.1016/j.cyto.2012.09.018DOI Listing
January 2013

Acute regulation of activin A and its binding protein, follistatin, in serum and tissues following lipopolysaccharide treatment of adult male mice.

Am J Physiol Regul Integr Comp Physiol 2012 Sep 1;303(6):R665-75. Epub 2012 Aug 1.

Monash Institute of Medical Research, Monash University, Melbourne, Victoria, Australia.

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http://dx.doi.org/10.1152/ajpregu.00478.2011DOI Listing
September 2012

Regulation of activin and inhibin in the adult testis and the evidence for functional roles in spermatogenesis and immunoregulation.

Mol Cell Endocrinol 2012 Aug 22;359(1-2):30-42. Epub 2011 Sep 22.

Monash Institute of Medical Research, Monash University, Melbourne, Victoria, Australia.

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http://dx.doi.org/10.1016/j.mce.2011.09.031DOI Listing
August 2012

The roles of activin A and its binding protein, follistatin, in inflammation and tissue repair.

Mol Cell Endocrinol 2012 Aug 20;359(1-2):101-6. Epub 2011 Oct 20.

Monash Institute of Medical Research and the Department of Immunology and Pathology, Monash University, Clayton Victoria 3800, Australia.

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http://dx.doi.org/10.1016/j.mce.2011.10.009DOI Listing
August 2012

Immunophysiology and pathology of inflammation in the testis and epididymis.

Authors:
Mark P Hedger

J Androl 2011 Nov-Dec;32(6):625-40. Epub 2011 Jul 15.

Monash Institute of Medical Research, Monash University, 27-31 Wright St, Clayton, Victoria, Australia.

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http://dx.doi.org/10.2164/jandrol.111.012989DOI Listing
February 2012

Tumour necrosis factor-α stimulates human neutrophils to release preformed activin A.

Immunol Cell Biol 2011 Nov 29;89(8):889-96. Epub 2011 Mar 29.

Centre for Reproduction and Development, Monash Institute of Medical Research, Clayton, Victoria, Australia.

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http://dx.doi.org/10.1038/icb.2011.12DOI Listing
November 2011

Rat resident testicular macrophages have an alternatively activated phenotype and constitutively produce interleukin-10 in vitro.

J Leukoc Biol 2011 Jul 15;90(1):133-43. Epub 2011 Apr 15.

Monash Institute of Medical Research, Monash University, 27-31 Wright St., Clayton, VIC, 3168, Australia.

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http://dx.doi.org/10.1189/jlb.1010557DOI Listing
July 2011

The regulation and functions of activin and follistatin in inflammation and immunity.

Vitam Horm 2011 ;85:255-97

Monash Institute of Medical Research, Monash University, Monash Medical Centre, Clayton, Victoria, Australia.

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http://dx.doi.org/10.1016/B978-0-12-385961-7.00013-5DOI Listing
June 2011

Pattern of activin A and follistatin release in a sheep model of cardiopulmonary bypass.

Cytokine 2011 May 12;54(2):154-60. Epub 2011 Feb 12.

Department of Surgery (Monash Medical Centre), Monash University, Victoria, Australia.

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http://dx.doi.org/10.1016/j.cyto.2011.01.001DOI Listing
May 2011

Differential responses of epithelial Sertoli cells of the rat testis to Toll-like receptor 2 and 4 ligands: implications for studies of testicular inflammation using bacterial lipopolysaccharides.

Innate Immun 2011 Apr 18;17(2):123-36. Epub 2009 Dec 18.

Centre for Reproduction and Development, Monash Institute of Medical Research, Monash University, 27-31 Wright Street, Clayton, Melbourne, Australia.

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http://dx.doi.org/10.1177/1753425909354764DOI Listing
April 2011

Immunological, paracrine and endocrine aspects of testicular immune privilege.

Mol Cell Endocrinol 2011 Mar 2;335(1):60-8. Epub 2010 Apr 2.

Department of Anatomy and Cell Biology, Justus-Liebig-University of Giessen, Aulweg 123, 35385 Giessen, Germany.

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http://dx.doi.org/10.1016/j.mce.2010.03.022DOI Listing
March 2011

Regulation of Sertoli cell activin A and inhibin B by tumour necrosis factor α and interleukin 1α: interaction with follicle-stimulating hormone/adenosine 3',5'-cyclic phosphate signalling.

Mol Cell Endocrinol 2011 Mar 20;335(2):195-203. Epub 2011 Jan 20.

Centre for Reproduction and Development, Monash Institute of Medical Research, Monash University, Melbourne, Victoria, Australia.

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http://dx.doi.org/10.1016/j.mce.2011.01.014DOI Listing
March 2011

Toll-like receptors and signalling in spermatogenesis and testicular responses to inflammation--a perspective.

Authors:
Mark P Hedger

J Reprod Immunol 2011 Mar 18;88(2):130-41. Epub 2011 Feb 18.

Centre for Reproduction and Development, Monash Institute of Medical Research, Monash University, 27-31 Wright Street, Clayton, Melbourne, Victoria 3168, Australia.

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http://dx.doi.org/10.1016/j.jri.2011.01.010DOI Listing
March 2011

Inflammatory networks in the control of spermatogenesis : chronic inflammation in an immunologically privileged tissue?

Adv Exp Med Biol 2008 ;636:92-114

Monash Institute of Medical Research, Monash University, Clayton, 3168, Australia.

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http://dx.doi.org/10.1007/978-0-387-09597-4_6DOI Listing
January 2010

Effects of chronic celecoxib on testicular function in normal and lipopolysaccharide-treated rats.

Int J Androl 2009 Oct 2;32(5):542-55. Epub 2008 Jun 2.

Monash Institute of Medical Research, Monash University, Clayton, Melbourne, Australia.

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http://dx.doi.org/10.1111/j.1365-2605.2008.00895.xDOI Listing
October 2009

Molecular aspects of male fertility. International Workshop on Molecular Andrology.

EMBO Rep 2009 Oct 18;10(10):1087-92. Epub 2009 Sep 18.

Department of Obstetrics and Gynecology, Center for Molecular Medicine and Genetics, Institute for Scientific Computing, Wayne State University School of Medicine, Detroit, MI, USA.

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http://dx.doi.org/10.1038/embor.2009.211DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2759745PMC
October 2009

Activin and related proteins in inflammation: not just interested bystanders.

Cytokine Growth Factor Rev 2009 Apr 3;20(2):153-64. Epub 2009 Mar 3.

Monash Institute of Medical Research, Monash University, Clayton, Victoria 3168, Australia.

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http://dx.doi.org/10.1016/j.cytogfr.2009.02.007DOI Listing
April 2009

Molecular identification of lyso-glycerophosphocholines as endogenous immunosuppressives in bovine and rat gonadal fluids.

Biol Reprod 2008 Sep 28;79(3):525-36. Epub 2008 May 28.

Monash Institute of Medical Research, Monash University, Clayton, Victoria, Australia.

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http://dx.doi.org/10.1095/biolreprod.107.064386DOI Listing
September 2008

Toll-like receptors in the gonads and reproductive tract: emerging roles in reproductive physiology and pathology.

Immunol Cell Biol 2007 Aug-Sep;85(6):481-9. Epub 2007 Jun 26.

Centre for Women's Health Research, Monash Institute of Medical Research, Monash University, Melbourne, Victoria, Australia.

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http://dx.doi.org/10.1038/sj.icb.7100086DOI Listing
November 2007

Activin A is a critical component of the inflammatory response, and its binding protein, follistatin, reduces mortality in endotoxemia.

Proc Natl Acad Sci U S A 2007 Oct 2;104(41):16239-44. Epub 2007 Oct 2.

Monash Institute of Medical Research, Monash University, Clayton, Victoria 3168, Australia.

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http://dx.doi.org/10.1073/pnas.0705971104DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2042191PMC
October 2007

Constitutive expression of prostaglandin-endoperoxide synthase 2 by somatic and spermatogenic cells is responsible for prostaglandin E2 production in the adult rat testis.

Biol Reprod 2007 May 24;76(5):759-68. Epub 2007 Jan 24.

Monash Institute of Medical Research, , Monash University, Clayton, Victoria 3168, Australia.

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http://dx.doi.org/10.1095/biolreprod.106.053124DOI Listing
May 2007

A stereological analysis of the response of spermatogenesis to an acute inflammatory episode in adult rats.

J Androl 2007 Jan-Feb;28(1):176-85. Epub 2006 Sep 20.

Monash Institute of Medical Research, Monash University, 27-31 Wright Street, Clayton, Victoria 3168, Australia.

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http://dx.doi.org/10.2164/jandrol.106.000752DOI Listing
March 2007

The relationship between immunosuppressive activity and immunoregulatory cytokines in seminal plasma: influence of sperm autoimmunity and seminal leukocytes.

J Reprod Immunol 2006 Aug 18;71(1):57-74. Epub 2006 May 18.

Monash Institute of Medical Research, Monash University, 27-31 Wright Street, Clayton, Vic. 3168, Australia.

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http://dx.doi.org/10.1016/j.jri.2006.01.002DOI Listing
August 2006

Cytokine profiles in the testes of rats treated with lipopolysaccharide reveal localized suppression of inflammatory responses.

Am J Physiol Regul Integr Comp Physiol 2005 Jun 20;288(6):R1744-55. Epub 2005 Jan 20.

Monash Institute of Reproduction and Development, Australian Research Council Centre of Excellence in Biotechnology and Development, Monash University, 246 Clayton Rd., Clayton, Victoria 3168, Australia.

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http://ajpregu.physiology.org/content/ajpregu/288/6/R1744.fu
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http://ajpregu.physiology.org/cgi/doi/10.1152/ajpregu.00651.
Publisher Site
http://dx.doi.org/10.1152/ajpregu.00651.2004DOI Listing
June 2005

Meiotic and epigenetic defects in Dnmt3L-knockout mouse spermatogenesis.

Proc Natl Acad Sci U S A 2005 Mar 7;102(11):4068-73. Epub 2005 Mar 7.

Genetics and Bioinformatics Division, The Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, Victoria 3050, Australia.

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http://dx.doi.org/10.1073/pnas.0500702102DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC552976PMC
March 2005

Identification of a novel apolipoprotein, ApoN, in ovarian follicular fluid.

Endocrinology 2004 Nov 15;145(11):5231-42. Epub 2004 Jul 15.

The Centre for Molecular Reproduction and Development, Monash Institute of Reproduction and Development, 27-31 Wright Street, Clayton 3168, Melbourne, Victoria, Australia.

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http://dx.doi.org/10.1210/en.2004-0630DOI Listing
November 2004

The novel angiotensin-converting enzyme (ACE) homolog, ACE2, is selectively expressed by adult Leydig cells of the testis.

Endocrinology 2004 Oct 1;145(10):4703-11. Epub 2004 Jul 1.

Baker Heart Research Institute, Melbourne 8008, Australia.

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http://dx.doi.org/10.1210/en.2004-0443DOI Listing
October 2004

Macrophages and the immune responsiveness of the testis.

Authors:
Mark P Hedger

J Reprod Immunol 2002 Oct-Nov;57(1-2):19-34

Monash Institute of Reproduction and Development, Monash Medical Centre, Monash University, Clayton, Melbourne, Vic., Australia.

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May 2003

Cytokines and the immune-testicular axis.

J Reprod Immunol 2003 Feb;58(1):1-26

Monash Institute of Reproduction and Development, Monash University, 27-31 Wright Street, Clayton, Melbourne, Victoria 3168, Australia.

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February 2003

The response of testicular leukocytes to lipopolysaccharide-induced inflammation: further evidence for heterogeneity of the testicular macrophage population.

Cell Tissue Res 2002 May 13;308(2):277-85. Epub 2002 Apr 13.

Monash Institute of Reproduction and Development, Monash University, Melbourne, Victoria, Australia.

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http://dx.doi.org/10.1007/s00441-002-0547-6DOI Listing
May 2002