Mark N Wu

Mark N Wu

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Mark N Wu

Mark N Wu

Publications by authors named "Mark N Wu"

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Semaphorin 2b Regulates Sleep-Circuit Formation in the Drosophila Central Brain.

Neuron 2019 Sep 26. Epub 2019 Sep 26.

Solomon H. Snyder Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA. Electronic address:

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http://dx.doi.org/10.1016/j.neuron.2019.07.019DOI Listing
September 2019

Sleep Duration and Cognition in a Nationally Representative Sample of U.S. Older Adults.

Am J Geriatr Psychiatry 2019 Jul 4. Epub 2019 Jul 4.

Department of Psychiatry and Behavioral Sciences (APS), Johns Hopkins University School of Medicine, Baltimore, MD; Department of Mental Health (APS), Johns Hopkins University Bloomberg School of Public Health, Baltimore, MD; Johns Hopkins University Center on Aging and Health (APS), Baltimore, MD.

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http://dx.doi.org/10.1016/j.jagp.2019.07.001DOI Listing
July 2019

Morning and Evening Circadian Pacemakers Independently Drive Premotor Centers via a Specific Dopamine Relay.

Neuron 2019 May 10;102(4):843-857.e4. Epub 2019 Apr 10.

Department of Neuroscience, Washington University in St. Louis, St. Louis, MO 63110, USA. Electronic address:

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http://dx.doi.org/10.1016/j.neuron.2019.03.028DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6533154PMC
May 2019

Clock-Generated Temporal Codes Determine Synaptic Plasticity to Control Sleep.

Cell 2018 11 11;175(5):1213-1227.e18. Epub 2018 Oct 11.

Department of Neurology, Johns Hopkins University, Baltimore, MD 21205, USA; Solomon H. Snyder Department of Neuroscience, Johns Hopkins University, Baltimore, MD 21205, USA. Electronic address:

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http://dx.doi.org/10.1016/j.cell.2018.09.016DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6239908PMC
November 2018

Time for Bed: Genetic Mechanisms Mediating the Circadian Regulation of Sleep.

Trends Genet 2018 05 24;34(5):379-388. Epub 2018 Jan 24.

Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA; McKusick-Nathans Institute of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA; Solomon H. Snyder Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA. Electronic address:

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http://dx.doi.org/10.1016/j.tig.2018.01.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5910202PMC
May 2018

A Genetic Toolkit for Dissecting Dopamine Circuit Function in Drosophila.

Cell Rep 2018 Apr;23(2):652-665

Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA; Solomon H. Snyder Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA.

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https://linkinghub.elsevier.com/retrieve/pii/S22111247183042
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http://dx.doi.org/10.1016/j.celrep.2018.03.068DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5962273PMC
April 2018

Sleep: Setting the 'Circadian' Alarm Clock.

Curr Biol 2018 01;28(1):R26-R28

Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA; Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA. Electronic address:

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http://dx.doi.org/10.1016/j.cub.2017.11.011DOI Listing
January 2018

APOE Genotype and Nonrespiratory Sleep Parameters in Cognitively Intact Older Adults.

Sleep 2017 08;40(8)

Intramural Research Program, National Institute on Aging, National Institutes of Health, Baltimore, MD.

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http://dx.doi.org/10.1093/sleep/zsx076DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5804995PMC
August 2017

Sleep Disturbance, Cognitive Decline, and Dementia: A Review.

Semin Neurol 2017 08 24;37(4):395-406. Epub 2017 Aug 24.

Department of Psychiatry and Behavioral Sciences, Johns Hopkins School of Medicine, Baltimore, Maryland.

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http://dx.doi.org/10.1055/s-0037-1604351DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5910033PMC
August 2017

The laminar organization of the ellipsoid body is semaphorin-dependent and prevents the formation of ectopic synaptic connections.

Elife 2017 06 20;6. Epub 2017 Jun 20.

The Solomon H. Snyder Department of Neuroscience, The Johns Hopkins University School of Medicine, Baltimore, United States.

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http://dx.doi.org/10.7554/eLife.25328DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5511011PMC
June 2017

An LHX1-Regulated Transcriptional Network Controls Sleep/Wake Coupling and Thermal Resistance of the Central Circadian Clockworks.

Curr Biol 2017 Jan 22;27(1):128-136. Epub 2016 Dec 22.

Solomon H. Snyder Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA; Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA; Department of Ophthalmology, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA; Center for Human Systems Biology, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA; Institute for Cell Engineering, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA. Electronic address:

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http://www.cell.com/current-biology/pdf/S0960-9822(16)31333-
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http://linkinghub.elsevier.com/retrieve/pii/S096098221631333
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http://dx.doi.org/10.1016/j.cub.2016.11.008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5269403PMC
January 2017

Sleep Drive Is Encoded by Neural Plastic Changes in a Dedicated Circuit.

Cell 2016 Jun 19;165(6):1347-1360. Epub 2016 May 19.

Department of Neurology, Johns Hopkins University, Baltimore, MD 21287, USA; Department of Neuroscience, Johns Hopkins University, Baltimore, MD 21287, USA. Electronic address:

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http://dx.doi.org/10.1016/j.cell.2016.04.013DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4892967PMC
June 2016

Sleep Duration and Subsequent Cortical Thinning in Cognitively Normal Older Adults.

Sleep 2016 05 1;39(5):1121-8. Epub 2016 May 1.

Intramural Research Program, National Institute on Aging, National Institutes of Health, Baltimore, MD.

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http://dx.doi.org/10.5665/sleep.5768DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4835311PMC
May 2016

Drosophila models of neurologic disease.

Exp Neurol 2015 Dec;274(Pt A):1-3

Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA; Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.

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http://dx.doi.org/10.1016/j.expneurol.2015.10.004DOI Listing
December 2015

Improved and expanded Q-system reagents for genetic manipulations.

Nat Methods 2015 Mar 12;12(3):219-22, 5 p following 222. Epub 2015 Jan 12.

The Solomon H. Snyder Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.

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http://www.nature.com/articles/nmeth.3250
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http://dx.doi.org/10.1038/nmeth.3250DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4344399PMC
March 2015

Sleep interacts with aβ to modulate intrinsic neuronal excitability.

Curr Biol 2015 Mar 5;25(6):702-712. Epub 2015 Mar 5.

Department of Neurology, Johns Hopkins University, Baltimore, MD 21205, USA; Department of Neuroscience, Johns Hopkins University, Baltimore, MD 21205, USA. Electronic address:

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http://dx.doi.org/10.1016/j.cub.2015.01.016DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4366315PMC
March 2015

Regulation of synaptic development and function by the Drosophila PDZ protein Dyschronic.

Development 2014 Dec 30;141(23):4548-57. Epub 2014 Oct 30.

Department of Neuroscience, The Farber Institute for Neurosciences, Thomas Jefferson University, Philadelphia, PA 19107, USA

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http://dev.biologists.org/cgi/doi/10.1242/dev.109538
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http://dx.doi.org/10.1242/dev.109538DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4302934PMC
December 2014

Impact of sleep on the risk of cognitive decline and dementia.

Curr Opin Psychiatry 2014 Nov;27(6):478-83

aDepartment of Mental Health, Johns Hopkins Bloomberg School of Public Health bDepartment of Psychiatry and Behavioral Sciences, Johns Hopkins School of Medicine cDepartments of Neurology and Neuroscience, Johns Hopkins School of Medicine, Baltimore, Maryland dDepartments of Psychiatry, Neurology, and Epidemiology and Biostatistics, University of California, San Francisco and San Francisco VA Medical Center, San Francisco, California, USA.

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http://content.wkhealth.com/linkback/openurl?sid=WKPTLP:land
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http://dx.doi.org/10.1097/YCO.0000000000000106DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4323377PMC
November 2014

Objectively Measured Sleep and β-amyloid Burden in Older Adults: A Pilot Study.

SAGE Open Med 2014 Aug;2

Department of Neurology, Johns Hopkins School of Medicine, Baltimore, MD ; Department of Neuroscience, Johns Hopkins School of Medicine, Baltimore, MD.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4304392PMC
http://dx.doi.org/10.1177/2050312114546520DOI Listing
August 2014

WIDE AWAKE mediates the circadian timing of sleep onset.

Neuron 2014 Apr 13;82(1):151-66. Epub 2014 Mar 13.

Department of Neurology, Johns Hopkins University, Baltimore, MD 21287, USA; Department of Neuroscience, Johns Hopkins University, Baltimore, MD 21287, USA. Electronic address:

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http://dx.doi.org/10.1016/j.neuron.2014.01.040DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3982794PMC
April 2014

Two dopaminergic neurons signal to the dorsal fan-shaped body to promote wakefulness in Drosophila.

Curr Biol 2012 Nov 27;22(22):2114-23. Epub 2012 Sep 27.

Department of Neurology, Johns Hopkins University, Baltimore, MD 21287, USA.

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http://dx.doi.org/10.1016/j.cub.2012.09.008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3505250PMC
November 2012

Notch signaling: a role in sleep and stress.

Curr Biol 2011 May;21(10):R397-8

Department of Neurology, Johns Hopkins University, Baltimore, MD 21287, USA.

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http://dx.doi.org/10.1016/j.cub.2011.04.014DOI Listing
May 2011

Genome-wide association studies of sleep disorders.

Chest 2011 Feb;139(2):446-452

Department of Neurology, Johns Hopkins University, Baltimore, MD. Electronic address:

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http://dx.doi.org/10.1378/chest.10-1313DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3032368PMC
February 2011

SLEEPLESS, a Ly-6/neurotoxin family member, regulates the levels, localization and activity of Shaker.

Nat Neurosci 2010 Jan 13;13(1):69-75. Epub 2009 Dec 13.

Division of Sleep Medicine, Department of Neurology, University of Pennsylvania, Philadelphia, Pennsylvania, USA.

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http://dx.doi.org/10.1038/nn.2454DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2842941PMC
January 2010

An isoform-specific mutant reveals a role of PDP1 epsilon in the circadian oscillator.

J Neurosci 2009 Sep;29(35):10920-7

Department of Neuroscience, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA.

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http://dx.doi.org/10.1523/JNEUROSCI.2133-09.2009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2757269PMC
September 2009

The effects of caffeine on sleep in Drosophila require PKA activity, but not the adenosine receptor.

J Neurosci 2009 Sep;29(35):11029-37

Division of Sleep Medicine, Department of Neurology, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA.

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http://dx.doi.org/10.1523/JNEUROSCI.1653-09.2009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2757164PMC
September 2009

Identification of SLEEPLESS, a sleep-promoting factor.

Science 2008 Jul;321(5887):372-6

Howard Hughes Medical Institute, Department of Neuroscience, University of Pennsylvania, Philadelphia, PA 19104, USA.

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http://dx.doi.org/10.1126/science.1155942DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2771549PMC
July 2008

A genetic screen for sleep and circadian mutants reveals mechanisms underlying regulation of sleep in Drosophila.

Sleep 2008 Apr;31(4):465-72

Division of Sleep Medicine, Department of Neurology, University of Pennsylvania, Philadelphia, PA 19104, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2279757PMC
http://dx.doi.org/10.1093/sleep/31.4.465DOI Listing
April 2008

Hemopericardium following intravenous thrombolysis for acute ischemic stroke.

Cerebrovasc Dis 2005 27;20(6):478-9. Epub 2005 Oct 27.

Department of Neurology, UCLA Medical Center, Los Angeles, Calif. 90095, USA.

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http://dx.doi.org/10.1159/000089336DOI Listing
January 2006

Hrs regulates endosome membrane invagination and tyrosine kinase receptor signaling in Drosophila.

Cell 2002 Jan;108(2):261-9

Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX 77030, USA.

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http://dx.doi.org/10.1016/s0092-8674(02)00611-6DOI Listing
January 2002