Mark Lawler

Mark Lawler

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Mark Lawler

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ACE: A Workbench Using Evolutionary Genetic Algorithms for Analyzing Association in TCGA.

Cancer Res 2019 Apr 13;79(8):2072-2075. Epub 2019 Feb 13.

Centre for Cancer Research and Cell Biology, Queen's University Belfast, Belfast, Northern Ireland, United Kingdom.

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http://dx.doi.org/10.1158/0008-5472.CAN-18-1976DOI Listing
April 2019

The value of European immigration for high-level UK research and clinical care: cross-sectional study.

J R Soc Med 2019 Jan 10;112(1):29-35. Epub 2018 Oct 10.

1 Comprehensive Cancer Centre, Institute of Cancer Policy, School of Cancer and Pharmaceutical Sciences, Guy's Hospital, King's College London, London SE1 9RT, UK.

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http://journals.sagepub.com/doi/10.1177/0141076818803427
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http://dx.doi.org/10.1177/0141076818803427DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6348557PMC
January 2019

Integrating Genomics into Healthcare: A Global Responsibility.

Am J Hum Genet 2019 Jan;104(1):13-20

Australian Genomics Health Alliance, Melbourne VIC 3052, Australia; Murdoch Children's Research Institute, Melbourne VIC 3052, Australia; Department of Paediatrics, University of Melbourne, Melbourne VIC 3052, Australia; Global Alliance for Genomics and Health, 661 University Avenue, Suite 510, Toronto, ON M5G 0A3, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.ajhg.2018.11.014DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6323624PMC
January 2019

The Value and Future Developments of Multidisciplinary Team Cancer Care.

Am Soc Clin Oncol Educ Book 2019 Jan(39):332-340

5 European School of Oncology, Milan, Italy.

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http://dx.doi.org/10.1200/EDBK_236857DOI Listing
January 2019

Mapping cancer research across Central and Eastern Europe, the Russian Federation and Central Asia: Implications for future national cancer control planning.

Eur J Cancer 2018 Nov 20;104:127-136. Epub 2018 Oct 20.

Institute of Cancer Policy, Cancer Epidemiology, Population & Global Health, School of Cancer Sciences, King's College London & Guy's & St.Thomas' NHS Trust, London, UK. Electronic address:

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http://dx.doi.org/10.1016/j.ejca.2018.08.024DOI Listing
November 2018

The impact of Brexit on UK cancer research.

Lancet Oncol 2018 Oct 1;19(10):1276-1278. Epub 2018 Oct 1.

King's College London, Institute of Cancer Policy, School of Cancer Studies, Guy's Hospital, London, UK.

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http://dx.doi.org/10.1016/S1470-2045(18)30518-7DOI Listing
October 2018

Mapping the European cancer research landscape: An evidence base for national and Pan-European research and funding.

Eur J Cancer 2018 09 4;100:75-84. Epub 2018 Jul 4.

King's College London, School of Cancer and Pharmaceutical Sciences, Guy's Hospital Campus, Great Maze Pond, London SE1 9RT, UK. Electronic address:

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http://dx.doi.org/10.1016/j.ejca.2018.04.017DOI Listing
September 2018

It is time for universal HPV vaccination.

Lancet 2018 09;392(10151):913-914

Centre for Cancer Research and Cell Biology, Queen's University Belfast, Belfast, BT9 7BL, UK; Royal Marsden Hospital, London, UK; European Cancer Concord/European Cancer Organisation Oncopolicy Forum, Brussels, Belgium. Electronic address:

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http://dx.doi.org/10.1016/S0140-6736(18)31821-XDOI Listing
September 2018

A roadmap for restoring trust in Big Data.

Lancet Oncol 2018 08;19(8):1014-1015

European Alliance for Personalised Medicine, Brussels, Belgium; Gustave Roussy Cancer Campus Grand Paris, Villejuif, France.

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http://dx.doi.org/10.1016/S1470-2045(18)30425-XDOI Listing
August 2018

Improving pathology and laboratory medicine in low-income and middle-income countries: roadmap to solutions.

Lancet 2018 05 15;391(10133):1939-1952. Epub 2018 Mar 15.

Center for Global Health, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA; Green Templeton College, University of Oxford, Oxford, UK.

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http://dx.doi.org/10.1016/S0140-6736(18)30459-8DOI Listing
May 2018

Delivering modern, high-quality, affordable pathology and laboratory medicine to low-income and middle-income countries: a call to action.

Lancet 2018 05 15;391(10133):1953-1964. Epub 2018 Mar 15.

Faculty of Medicine, Health and Life Sciences and Centre for Cancer Research and Cell Biology, Queens University, Belfast, UK.

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http://dx.doi.org/10.1016/S0140-6736(18)30460-4DOI Listing
May 2018

Mapping the cancer patient information landscape: A comparative analysis of patient groups across Europe and North America.

Eur J Cancer 2018 03 9;92:88-95. Epub 2018 Feb 9.

Institute of Cancer Policy, Division of Cancer Studies, Kings' College London and King's Health Partners Comprehensive Cancer Centre, London, UK.

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http://dx.doi.org/10.1016/j.ejca.2018.01.074DOI Listing
March 2018

Targeting c-MET in gastrointestinal tumours: rationale, opportunities and challenges.

Nat Rev Clin Oncol 2017 09 4;14(9):562-576. Epub 2017 Apr 4.

Drug Resistance Group, Centre for Cancer Research and Cell Biology, School of Medicine, Dentistry and Biomedical Science, Queen's University Belfast, 97 Lisburn Road, Belfast BT9 7AE, UK.

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http://dx.doi.org/10.1038/nrclinonc.2017.40DOI Listing
September 2017

Standardising RNA profiling based biomarker application in cancer-The need for robust control of technical variables.

Biochim Biophys Acta Rev Cancer 2017 Aug 23;1868(1):258-272. Epub 2017 May 23.

Centre for Cancer Research and Cell Biology, Queen's University Belfast, UK; Northern Ireland Molecular Pathology Laboratory, Queen's University Belfast, UK. Electronic address:

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http://dx.doi.org/10.1016/j.bbcan.2017.05.005DOI Listing
August 2017

Intratumoural Epigenetic Heterogeneity in Early Invasive Colorectal Cancer: A Prognostic Imprint?

Gastroenterology 2017 05 3;152(6):1622-1623. Epub 2017 Apr 3.

Centre for Cancer Research and Cell Biology, Queen's University, Belfast, United Kingdom.

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http://dx.doi.org/10.1053/j.gastro.2016.09.071DOI Listing
May 2017

From Rosalind Franklin to Barack Obama: Data Sharing Challenges and Solutions in Genomics and Personalised Medicine.

New Bioeth 2017 Apr;23(1):64-73

c CRUK/MRC Oxford Institute for Radiation Oncology, University of Oxford , Oxford , UK.

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http://dx.doi.org/10.1080/20502877.2017.1314883DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5448399PMC
April 2017

Enabling Equal Access to Molecular Diagnostics: What Are the Implications for Policy and Health Technology Assessment?

Public Health Genomics 2016 1;19(3):144-52. Epub 2016 Jun 1.

Genomic Health International SARL, Geneva, Switzerland.

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http://dx.doi.org/10.1159/000446532DOI Listing
February 2017

Shooting for the Moon or Flying Too Near the Sun? Crossing the Value Rubicon in Precision Cancer Care.

Public Health Genomics 2016;19(3):132-6. Epub 2016 Jun 1.

Centre for Cancer Research and Cell Biology, Queen's University, Belfast, UK.

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http://dx.doi.org/10.1159/000446530DOI Listing
February 2017

The potential consequences for cancer care and cancer research of Brexit.

Ecancermedicalscience 2017 24;11:ed63. Epub 2017 Feb 24.

Francis Crick Institute, 1 Midland Rd, Kings Cross, London, NW1 1AT, UK.

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http://dx.doi.org/10.3332/ecancer.2017.ed63DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5336387PMC
February 2017

Transcriptional upregulation of c-MET is associated with invasion and tumor budding in colorectal cancer.

Oncotarget 2016 Nov;7(48):78932-78945

Drug Resistance Group, Centre for Cancer Research and Cell Biology, School of Medicine, Dentistry and Biomedical Science, Queen's University Belfast, Belfast, UK.

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http://dx.doi.org/10.18632/oncotarget.12933DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5346688PMC
November 2016

Personalised and Precision Medicine in Cancer Clinical Trials: Panacea for Progress or Pandora's Box?

Public Health Genomics 2015 11;18(6):329-37. Epub 2015 Nov 11.

Centre for Cancer Research and Cell Biology, Queen's University Belfast, Belfast, UK.

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http://dx.doi.org/10.1159/000441555DOI Listing
October 2016

Establishing the Evidence Bar for Molecular Diagnostics in Personalised Cancer Care.

Public Health Genomics 2015 11;18(6):349-58. Epub 2015 Nov 11.

Genomic Health International Sx00E0;rl, Geneva, Switzerland.

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http://dx.doi.org/10.1159/000441556DOI Listing
October 2016

Minor allele frequency of myeloproliferative neoplasm mutations in the Irish blood donor population.

Hematol Oncol 2016 Sep 3;34(3):161-4. Epub 2015 Feb 3.

Centre for Cancer Research and Cell Biology, Queen's University Belfast, Belfast, Northern Ireland, UK.

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http://dx.doi.org/10.1002/hon.2190DOI Listing
September 2016

The EU: what's best for UK cancer research and patients?

Lancet Oncol 2016 05 27;17(5):556-7. Epub 2016 Apr 27.

European Cancer Concord, Leeds, UK; Francis Crick Institute, London, UK.

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http://dx.doi.org/10.1016/S1470-2045(16)30063-8DOI Listing
May 2016

Getting Personal: Accelerating Personalised and Precision Medicine Integration into Clinical Cancer Research and Care in Clinical Trials.

Public Health Genomics 2015 14;18(6):325-8. Epub 2015 Nov 14.

European Alliance for Personalised Medicine, Brussels, Belgium.

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http://dx.doi.org/10.1159/000441554DOI Listing
April 2016

Overcoming Resistance to Targeted Therapies in Cancer.

Semin Oncol 2015 Dec 25;42(6):896-908. Epub 2015 Sep 25.

Centre for Cancer Research and Cell Biology, School of Medicine, Dentistry and Biomedical Science, Queen's University Belfast, Belfast, United Kingdom. Electronic address:

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http://dx.doi.org/10.1053/j.seminoncol.2015.09.028DOI Listing
December 2015

Changing the Paradigm—Multistage Multiarm Randomized Trials and Stratified Cancer Medicine.

Oncologist 2015 Aug 12;20(8):849-51. Epub 2015 Jun 12.

Cancer Research UK/Medical Research Council Oxford Institute for Radiation Oncology, University of Oxford, Oxford, United Kingdom.

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http://dx.doi.org/10.1634/theoncologist.2015-0014DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4524758PMC
August 2015

HDAC Inhibition Overcomes Acute Resistance to MEK Inhibition in BRAF-Mutant Colorectal Cancer by Downregulation of c-FLIPL.

Clin Cancer Res 2015 Jul 26;21(14):3230-3240. Epub 2015 Mar 26.

Centre for Cancer Research and Cell Biology, School of Medicine, Dentistry and Biomedical Science, Queen's University Belfast, 97 Lisburn Road, Belfast, BT9 7AE, UK.

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http://clincancerres.aacrjournals.org/cgi/doi/10.1158/1078-0
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http://dx.doi.org/10.1158/1078-0432.CCR-14-2701DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4504978PMC
July 2015

Is precision medicine the route to a healthy world?

Lancet 2015 Jul;386(9991):336-7

Centre for Cancer Research and Cell Biology, Queen's University Belfast, Belfast BT9 7AE, UK. Electronic address:

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http://www.thelancet.com/pdfs/journals/lancet/PIIS0140-6736(
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http://linkinghub.elsevier.com/retrieve/pii/S014067361561404
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http://dx.doi.org/10.1016/S0140-6736(15)61404-0DOI Listing
July 2015

Silencing the voice of scientific reason.

Authors:
Mark Lawler

Lancet Oncol 2015 Jan 29;16(1):e4-5. Epub 2014 Dec 29.

Centre for Cancer Research and Cell Biology, Queen's University Belfast, Belfast BT9 7BL, UK. Electronic address:

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http://dx.doi.org/10.1016/S1470-2045(14)71174-XDOI Listing
January 2015

John Fitzpatrick: an appreciation.

Oncologist 2015 Jan;20(1):e1-2

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4294620PMC
January 2015

Addressing cancer disparities in Europe: a multifaceted problem that requires interdisciplinary solutions.

Oncologist 2013 ;18(12):e29-30

Medical Directorate National Health Service England, Leeds, United Kingdom.

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http://dx.doi.org/10.1634/theoncologist.2013-0438DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3868434PMC
August 2014

ADAM17-dependent c-MET-STAT3 signaling mediates resistance to MEK inhibitors in KRAS mutant colorectal cancer.

Cell Rep 2014 Jun 12;7(6):1940-55. Epub 2014 Jun 12.

Centre for Cancer Research and Cell Biology, School of Medicine, Dentistry and Biomedical Science, Queen's University Belfast, 97 Lisburn Road, Belfast BT9 7AE, UK. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2014.05.032DOI Listing
June 2014

A Bill of Rights for patients with cancer in Europe.

Lancet Oncol 2014 Mar 4;15(3):258-60. Epub 2014 Feb 4.

Centre for Cancer Research and Cell Biology and Institute of Health Sciences, School of Medicine, Dentistry and Biomedical Sciences, Queens University Belfast, Belfast BT9 7BL, UK.

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http://www.thelancet.com/pdfs/journals/lanonc/PIIS1470-2045(
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http://linkinghub.elsevier.com/retrieve/pii/S147020451370552
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http://dx.doi.org/10.1016/S1470-2045(13)70552-7DOI Listing
March 2014

Ageism in cancer care.

BMJ 2014 Feb 28;348:g1614. Epub 2014 Feb 28.

Centre for Cancer Research and Cell Biology, Queen's University Belfast, Belfast BT9 7AE UK.

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http://dx.doi.org/10.1136/bmj.g1614DOI Listing
February 2014

America's cancer care crisis--is Europe any better?

Lancet 2013 Nov;382(9905):1628

Centre for Cancer Research and Cell Biology, School of Medicine, Dentistry and Biomedical Sciences, Queens University Belfast, Belfast BT9 7AE, UK. Electronic address:

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http://dx.doi.org/10.1016/S0140-6736(13)62362-4DOI Listing
November 2013

Docetaxel maintains its cytotoxic activity under hypoxic conditions in prostate cancer cells.

Urol Oncol 2012 Nov-Dec;30(6):912-9. Epub 2010 Dec 21.

Prostate Molecular Oncology Research Group, Academic Unit of Clinical and Molecular Oncology, Institute of Molecular Medicine, St. James's Hospital and Trinity College Dublin, Dublin, Ireland.

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http://linkinghub.elsevier.com/retrieve/pii/S107814391000234
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http://dx.doi.org/10.1016/j.urolonc.2010.08.015DOI Listing
July 2013

Personalized cancer medicine: are we there yet?

Oncologist 2013 Jun;18(6):649-50

Centre for Cancer Research and Cell Biology, Queen's University Belfast, Northern Ireland, United Kingdom.

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http://dx.doi.org/10.1634/theoncologist.2013-0189DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4063386PMC
June 2013

Gene expression and epigenetic discovery screen reveal methylation of SFRP2 in prostate cancer.

Int J Cancer 2013 Apr 28;132(8):1771-80. Epub 2012 Sep 28.

Prostate Molecular Oncology, Department of Clinical Medicine, Institute of Molecular Medicine, Trinity College Dublin, Ireland.

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http://dx.doi.org/10.1002/ijc.27798DOI Listing
April 2013

Expert opinion: future frontiers and challenges in cancer medicine.

Oncologist 2012 ;17(5):e3-5

School of Medicine, Dentistry & Biomedical Sciences, Queen's University Belfast, Northern Ireland, United Kingdom.

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http://theoncologist.alphamedpress.org/cgi/doi/10.1634/theon
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http://dx.doi.org/10.1634/theoncologist.2012-0210DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3360916PMC
January 2013

IGFBP7 promoter methylation and gene expression analysis in prostate cancer.

J Urol 2012 Oct 17;188(4):1354-60. Epub 2012 Aug 17.

Prostate Molecular Oncology, Institute of Molecular Medicine, Trinity College Dublin, Dublin, Ireland.

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https://linkinghub.elsevier.com/retrieve/pii/S00225347120390
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http://dx.doi.org/10.1016/j.juro.2012.06.002DOI Listing
October 2012

Clinical potential of gene-directed enzyme prodrug therapy to improve radiation therapy in prostate cancer patients.

Cancer Treat Rev 2011 Dec 9;37(8):643-54. Epub 2011 Apr 9.

Institute of Molecular Medicine, Trinity Centre for Health Sciences, St James's Hospital, Dublin, Ireland.

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http://dx.doi.org/10.1016/j.ctrv.2011.03.003DOI Listing
December 2011

The role of secreted frizzled-related protein 2 expression in prostate cancer.

Histopathology 2011 Dec;59(6):1240-8

Department of Pathology, RCSI Education & Research Centre, Royal College of Surgeons in Ireland, Beaumont Hospital, Dublin, Ireland.

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http://doi.wiley.com/10.1111/j.1365-2559.2011.04073.x
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http://dx.doi.org/10.1111/j.1365-2559.2011.04073.xDOI Listing
December 2011

BubR1 is required for the mitotic block induced by combretastatin-A4 and a novel cis-restricted ß-lactam analogue in human cancer cells.

Int J Mol Med 2011 May 2;27(5):715-23. Epub 2011 Mar 2.

School of Biochemistry and Immunology, Trinity College Dublin, College Green, Dublin 2, Ireland.

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http://dx.doi.org/10.3892/ijmm.2011.633DOI Listing
May 2011

Microtubule-targeting-compound PBOX-15 radiosensitizes cancer cells in vitro.

Cancer Biol Ther 2011 Feb 15;11(4):421-8. Epub 2011 Feb 15.

Prostate Molecular Oncology Research Group, Academic Unit of Clinical and Molecular Oncology, St James's Hospital and Trinity College Dublin, Ireland.

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http://dx.doi.org/10.4161/cbt.11.4.14183DOI Listing
February 2011

Novel microtubule-targeting agents, pyrrolo-1,5-benzoxazepines, induce cell cycle arrest and apoptosis in prostate cancer cells.

Oncol Rep 2010 Dec;24(6):1499-507

School of Biochemistry and Immunology, Trinity College, Dublin 2, Ireland.

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December 2010

The epigenome as a therapeutic target in prostate cancer.

Nat Rev Urol 2010 Dec 9;7(12):668-80. Epub 2010 Nov 9.

Prostate Molecular Oncology, Trinity Centre for Health Sciences, St James's Hospital, Dublin 8, Ireland.

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http://dx.doi.org/10.1038/nrurol.2010.185DOI Listing
December 2010

DNA mismatch repair and the DNA damage response to ionizing radiation: making sense of apparently conflicting data.

Cancer Treat Rev 2010 Nov 21;36(7):518-27. Epub 2010 Apr 21.

Prostate Molecular Oncology Research Group, Academic Unit of Clinical and Molecular Oncology, Institute of Molecular Medicine, Trinity College Dublin, Ireland.

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http://dx.doi.org/10.1016/j.ctrv.2010.03.008DOI Listing
November 2010

MAD2 downregulation in hypoxia is independent of promoter hypermethylation.

Cell Cycle 2010 Jul 12;9(14):2856-65. Epub 2010 Jul 12.

UCD School of Medicine and Medical Science (SMMS), University College Dublin, Belfield, Dublin, Ireland.

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July 2010

DNA mismatch repair and the transition to hormone independence in breast and prostate cancer.

Cancer Lett 2010 May 5;291(2):142-9. Epub 2009 Nov 5.

Division of Radiation Therapy, School of Medicine, Trinity College Dublin, Ireland.

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http://dx.doi.org/10.1016/j.canlet.2009.10.007DOI Listing
May 2010

Dual targeting of tumour cells and host endothelial cells by novel microtubule-targeting agents, pyrrolo-1,5-benzoxazepines.

Cancer Chemother Pharmacol 2010 Jan;65(2):289-300

School of Biochemistry and Immunology, Trinity College, Dublin, Ireland.

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http://dx.doi.org/10.1007/s00280-009-1033-6DOI Listing
January 2010

4-Amino-1,8-naphthalimide-based Tröger's bases as high affinity DNA targeting fluorescent supramolecular scaffolds.

Org Lett 2009 Sep;11(18):4040-3

School of Chemistry, Center for Synthesis and Chemical Biology, Trinity College Dublin, Dublin 2, Ireland.

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http://dx.doi.org/10.1021/ol9013602DOI Listing
September 2009

BubR1 is required for a sustained mitotic spindle checkpoint arrest in human cancer cells treated with tubulin-targeting pyrrolo-1,5-benzoxazepines.

Mol Pharmacol 2008 Feb 8;73(2):419-30. Epub 2007 Nov 8.

School of Biochemistry and Immunology, Trinity College, Dublin 2, United Kingdom.

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http://dx.doi.org/10.1124/mol.107.039024DOI Listing
February 2008

Discovery of DNA hypermethylation using a DHPLC screening strategy.

Epigenetics 2007 Jan-Mar;2(1):43-9. Epub 2007 Jan 15.

Department of Haematology and Academic Unit of Clinical and Molecular Oncology, Institute of Molecular Medicine, St. James's Hospital and Trinity College, Dublin, Ireland.

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http://dx.doi.org/10.4161/epi.2.1.3882DOI Listing
January 2008

Variation in DNA repair genes XRCC3, XRCC4, XRCC5 and susceptibility to myeloma.

Hum Mol Genet 2007 Dec 26;16(24):3117-27. Epub 2007 Sep 26.

Durkan Leukaemia Laboratories, Department of Haematology, Institute of Molecular Medicine, Trinity College Dublin, Ireland.

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http://dx.doi.org/10.1093/hmg/ddm273DOI Listing
December 2007

CD38 expression level and pattern of expression remains a reliable and robust marker of progressive disease in chronic lymphocytic leukemia.

Leuk Lymphoma 2006 Nov;47(11):2371-9

Department of Haematology and Durkan Laboratories, Institute of Molecular Medicine, Trinity College and St James Hospital, Dublin, Ireland.

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http://dx.doi.org/10.1080/10428190600947727DOI Listing
November 2006

Identification of tubulin as the molecular target of proapoptotic pyrrolo-1,5-benzoxazepines.

Mol Pharmacol 2006 Jul 29;70(1):60-70. Epub 2006 Mar 29.

School of Biochemistry and Immunology, Trinity College, Dublin 2, Ireland.

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http://dx.doi.org/10.1124/mol.105.021204DOI Listing
July 2006

The emerging roles of DNA methylation in the clinical management of prostate cancer.

Endocr Relat Cancer 2006 Jun;13(2):357-77

Institute of Molecular Medicine, Trinity College Dublin, Ireland.

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http://dx.doi.org/10.1677/erc.1.01184DOI Listing
June 2006

Hemopoietic chimerism following stem cell transplantation.

Transfus Apher Sci 2005 Feb;32(1):55-61

Department of Hematology, St James's Hospital/University of Dublin, Trinity College, Durkan Building, Trinity Center, Dublin 8, Ireland.

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http://dx.doi.org/10.1016/j.transci.2004.10.006DOI Listing
February 2005

Synthesis of N3- and 2-NH2-substituted 6,7-diphenylpterins and their use as intermediates for the preparation of oligonucleotide conjugates designed to target photooxidative damage on single-stranded DNA representing the bcr-abl chimeric gene.

Org Biomol Chem 2004 Dec 15;2(24):3588-601. Epub 2004 Nov 15.

Chemistry Department and Centre for Chemical Synthesis and Chemical Biology, Trinity College, University of Dublin, Dublin 2, Ireland.

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http://dx.doi.org/10.1039/b413655aDOI Listing
December 2004