Mark LaBarge

Mark LaBarge

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Mark LaBarge

Mark LaBarge

Publications by authors named "Mark LaBarge"

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A Non-canonical Function of BMAL1 Metabolically Limits Obesity-Promoted Triple-Negative Breast Cancer.

iScience 2020 Jan 14;23(2):100839. Epub 2020 Jan 14.

Department of Diabetes Complications and Metabolism, Beckman Research Institute, City of Hope, Duarte, CA 91010, USA; Irell & Manella Graduate School of Biological Sciences, City of Hope, Duarte, CA 91010, USA. Electronic address:

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http://dx.doi.org/10.1016/j.isci.2020.100839DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6997869PMC
January 2020

Developing a clinical and biological measures of aging core: Cancer and aging research group infrastructure.

J Geriatr Oncol 2019 Sep 16. Epub 2019 Sep 16.

Section of Hematology and Oncology, Department of Internal Medicine, Wake Forest School of Medicine, Winston-Salem, NC, United States of America.

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http://dx.doi.org/10.1016/j.jgo.2019.09.006DOI Listing
September 2019

Breast Tissue Biology Expands the Possibilities for Prevention of Age-Related Breast Cancers.

Front Cell Dev Biol 2019 28;7:174. Epub 2019 Aug 28.

Department of Biological Systems and Engineering, Lawrence Berkeley National Laboratory, Berkeley, CA, United States.

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http://dx.doi.org/10.3389/fcell.2019.00174DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6722426PMC
August 2019

Different culture media modulate growth, heterogeneity, and senescence in human mammary epithelial cell cultures.

PLoS One 2018 1;13(10):e0204645. Epub 2018 Oct 1.

Biological Systems and Engineering Division, Lawrence Berkeley National Laboratory, Berkeley, CA, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0204645PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6166958PMC
March 2019

Delayed γH2AX foci disappearance in mammary epithelial cells from aged women reveals an age-associated DNA repair defect.

Aging (Albany NY) 2019 03;11(5):1510-1523

Department of Cell Biology, Physiology and Immunology, Universitat Autònoma de Barcelona, 08193 Bellaterra, Spain.

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http://dx.doi.org/10.18632/aging.101849DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6428106PMC
March 2019

How cancer therapeutics cause accelerated aging: Insights from the hallmarks of aging.

J Geriatr Oncol 2019 Mar 21. Epub 2019 Mar 21.

Department of Medical Oncology and Therapeutics Research, City of Hope Comprehensive Cancer Center, United States; Center for Cancer and Aging, City of Hope Comprehensive Cancer Center, Duarte, California, United States.

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http://dx.doi.org/10.1016/j.jgo.2019.03.007DOI Listing
March 2019

Genetic variation and radiation quality impact cancer promoting cellular phenotypes in response to HZE exposure.

Life Sci Space Res (Amst) 2019 Feb 21;20:101-112. Epub 2018 Oct 21.

Department of Health Physics and Diagnostic Sciences, University of Nevada Las Vegas, Las Vegas, NV 89154, USA. Electronic address:

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http://dx.doi.org/10.1016/j.lssr.2018.10.002DOI Listing
February 2019

Hijacking EMT: Better Fat Than Dead.

Cancer Cell 2019 01;35(1):1-2

Department of Population Sciences, Beckman Research Institute at City of Hope, Duarte, CA 91010, USA. Electronic address:

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http://dx.doi.org/10.1016/j.ccell.2018.12.007DOI Listing
January 2019

Tissue aging: the integration of collective and variant responses of cells to entropic forces over time.

Curr Opin Cell Biol 2018 10 19;54:121-129. Epub 2018 Jun 19.

Department of Populations Sciences, and Center for Cancer and Aging, Beckman Research Institute at City of Hope, 1500 E Duarte Rd, Duarte, CA 91011 USA. Electronic address:

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http://dx.doi.org/10.1016/j.ceb.2018.05.016DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6258070PMC
October 2018

New Horizons in Advocacy Engaged Physical Sciences and Oncology Research.

Trends Cancer 2018 04 15;4(4):260-264. Epub 2018 Mar 15.

Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, CA, 94115, USA; Department of Surgery and Center for Bioengineering and Tissue Regeneration, University of California, San Francisco, CA, 94143, USA; Departments of Anatomy and Bioengineering and Therapeutic Sciences and Eli and Edythe Broad Center for Regeneration Medicine and Stem Cell Research, University of California, San Francisco, CA, 94143, USA.

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https://linkinghub.elsevier.com/retrieve/pii/S24058033183003
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http://dx.doi.org/10.1016/j.trecan.2018.02.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6932745PMC
April 2018

High-Dimensional Phenotyping Identifies Age-Emergent Cells in Human Mammary Epithelia.

Cell Rep 2018 04;23(4):1205-1219

Department of Biomedicine, University of Bergen, Bergen 5009, Norway; Centre for Cancer Biomarkers (CCBIO), University of Bergen, Bergen 5009, Norway. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S22111247183049
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http://dx.doi.org/10.1016/j.celrep.2018.03.114DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5946804PMC
April 2018

Characterizing cellular mechanical phenotypes with mechano-node-pore sensing.

Microsyst Nanoeng 2018 12;4. Epub 2018 Mar 12.

Department of Mechanical Engineering, University of California at Berkeley, Berkeley, California, USA.

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http://www.nature.com/articles/micronano201791
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http://dx.doi.org/10.1038/micronano.2017.91DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5958920PMC
March 2018

Breast Cancer beyond the Age of Mutation.

Gerontology 2016 6;62(4):434-42. Epub 2015 Nov 6.

Biological Systems and Engineering Division, Lawrence Berkeley National Laboratory, Berkeley, Calif., USA.

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http://dx.doi.org/10.1159/000441030DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4860162PMC
January 2018

The Library of Integrated Network-Based Cellular Signatures NIH Program: System-Level Cataloging of Human Cells Response to Perturbations.

Authors:
Alexandra B Keenan Sherry L Jenkins Kathleen M Jagodnik Simon Koplev Edward He Denis Torre Zichen Wang Anders B Dohlman Moshe C Silverstein Alexander Lachmann Maxim V Kuleshov Avi Ma'ayan Vasileios Stathias Raymond Terryn Daniel Cooper Michele Forlin Amar Koleti Dusica Vidovic Caty Chung Stephan C Schürer Jouzas Vasiliauskas Marcin Pilarczyk Behrouz Shamsaei Mehdi Fazel Yan Ren Wen Niu Nicholas A Clark Shana White Naim Mahi Lixia Zhang Michal Kouril John F Reichard Siva Sivaganesan Mario Medvedovic Jaroslaw Meller Rick J Koch Marc R Birtwistle Ravi Iyengar Eric A Sobie Evren U Azeloglu Julia Kaye Jeannette Osterloh Kelly Haston Jaslin Kalra Steve Finkbiener Jonathan Li Pamela Milani Miriam Adam Renan Escalante-Chong Karen Sachs Alex Lenail Divya Ramamoorthy Ernest Fraenkel Gavin Daigle Uzma Hussain Alyssa Coye Jeffrey Rothstein Dhruv Sareen Loren Ornelas Maria Banuelos Berhan Mandefro Ritchie Ho Clive N Svendsen Ryan G Lim Jennifer Stocksdale Malcolm S Casale Terri G Thompson Jie Wu Leslie M Thompson Victoria Dardov Vidya Venkatraman Andrea Matlock Jennifer E Van Eyk Jacob D Jaffe Malvina Papanastasiou Aravind Subramanian Todd R Golub Sean D Erickson Mohammad Fallahi-Sichani Marc Hafner Nathanael S Gray Jia-Ren Lin Caitlin E Mills Jeremy L Muhlich Mario Niepel Caroline E Shamu Elizabeth H Williams David Wrobel Peter K Sorger Laura M Heiser Joe W Gray James E Korkola Gordon B Mills Mark LaBarge Heidi S Feiler Mark A Dane Elmar Bucher Michel Nederlof Damir Sudar Sean Gross David F Kilburn Rebecca Smith Kaylyn Devlin Ron Margolis Leslie Derr Albert Lee Ajay Pillai

Cell Syst 2018 01 29;6(1):13-24. Epub 2017 Nov 29.

NIH, Bethesda, MD 20892, USA.

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http://dx.doi.org/10.1016/j.cels.2017.11.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5799026PMC
January 2018

Opportunities for organoids as new models of aging.

J Cell Biol 2018 01 20;217(1):39-50. Epub 2017 Dec 20.

Department of Pharmaceutical Chemistry, University of California San Francisco, San Francisco, CA

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http://dx.doi.org/10.1083/jcb.201709054DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5748992PMC
January 2018

Combinatorial Microenvironments Impose a Continuum of Cellular Responses to a Single Pathway-Targeted Anti-cancer Compound.

Cell Rep 2017 Oct;21(2):533-545

Department of Population Sciences, City of Hope, Duarte, CA 91010, USA; Biological Systems and Engineering Division, Lawrence Berkeley National Laboratory, Berkeley, CA 94720, USA; Center for Cancer Biomarkers, University of Bergen, Bergen 5009, Norway. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2017.09.058DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5648071PMC
October 2017

Cell and Tissue Biology Paves a Path to Breast Cancer Prevention.

Trends Cancer 2017 05 18;3(5):313-315. Epub 2017 Apr 18.

Department of Population Sciences, City of Hope, Duarte, CA 91010, USA. Electronic address:

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http://dx.doi.org/10.1016/j.trecan.2017.03.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5728114PMC
May 2017

Microsphere cytometry to interrogate microenvironment-dependent cell signaling.

Integr Biol (Camb) 2017 02;9(2):123-134

Department of Biomedicine, Center for Cancer Biomarkers, University of Bergen, Bergen, Norway.

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http://dx.doi.org/10.1039/c6ib00207bDOI Listing
February 2017

Lesion complexity drives age related cancer susceptibility in human mammary epithelial cells.

Aging (Albany NY) 2017 02;9(3):665-686

Division of Biological Systems and Engineering, Department of Organismal Systems and Bioresilience, Lawrence Berkeley National Laboratory, Berkeley, CA 94803, USA.

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http://dx.doi.org/10.18632/aging.101183DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5391225PMC
February 2017

Microenvironment rigidity modulates responses to the HER2 receptor tyrosine kinase inhibitor lapatinib via YAP and TAZ transcription factors.

Mol Biol Cell 2015 Nov 2;26(22):3946-53. Epub 2015 Sep 2.

Biological Systems and Engineering Division, Lawrence Berkeley National Laboratory, Berkeley, CA 94720

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http://dx.doi.org/10.1091/mbc.E15-07-0456DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4710228PMC
November 2015

Programmed synthesis of three-dimensional tissues.

Nat Methods 2015 Oct 31;12(10):975-81. Epub 2015 Aug 31.

Department of Pharmaceutical Chemistry, University of California, San Francisco, San Francisco, California, USA.

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http://www.gartnerlab.ucsf.edu/papers/TodhunterJee_Nmethods_
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http://www.nature.com/doifinder/10.1038/nmeth.3553
Publisher Site
http://dx.doi.org/10.1038/nmeth.3553DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4589502PMC
October 2015

Formation of spatially and geometrically controlled three-dimensional tissues in soft gels by sacrificial micromolding.

Tissue Eng Part C Methods 2015 Jun 11;21(6):541-7. Epub 2014 Dec 11.

1UC Berkeley-UCSF Graduate Program in Bioengineering, Department of Bioengineering, University of California Berkeley, Berkeley, California.

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http://dx.doi.org/10.1089/ten.TEC.2014.0450DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4442595PMC
June 2015

A strategy for tissue self-organization that is robust to cellular heterogeneity and plasticity.

Proc Natl Acad Sci U S A 2015 Feb 29;112(7):2287-92. Epub 2015 Jan 29.

University of California at Berkeley-University of California at San Francisco Graduate Program in Bioengineering, University of California, Berkeley, CA 94720; Pharmaceutical Chemistry, and Center for Systems and Synthetic Biology, University of California, San Francisco, CA 94143;

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http://dx.doi.org/10.1073/pnas.1410776112DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4343104PMC
February 2015

Molecular deconstruction, detection, and computational prediction of microenvironment-modulated cellular responses to cancer therapeutics.

Adv Drug Deliv Rev 2014 Apr 26;69-70:123-31. Epub 2014 Feb 26.

Department of Biomedicine and Center for Cancer Biomarkers, University of Bergen, Jonas Lies vei 91, NO-5020 Bergen, Norway. Electronic address:

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http://dx.doi.org/10.1016/j.addr.2014.02.009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4019691PMC
April 2014

CUL4A induces epithelial-mesenchymal transition and promotes cancer metastasis by regulating ZEB1 expression.

Cancer Res 2014 Jan 4;74(2):520-31. Epub 2013 Dec 4.

Authors' Affiliations: Department of Human Anatomy and Key Laboratory of Experimental Teratology, Ministry of Education; Department of Biochemistry and Molecular Biology, Shandong University School of Medicine; Department of Respiratory Medicine, Qilu Hospital, Shandong University, Jinan; International Biotechnology R&D Center, Shandong University School of Ocean, Weihai, Shandong, China; Life Sciences Division, Lawrence Berkeley National Laboratory, Berkeley; Department of Pathology; Thoracic Oncology Laboratory, Department of Surgery; Helen Diller Family Comprehensive Cancer Center and Department of Laboratory Medicine, University of California at San Francisco, San Francisco, California; and Department of Biomedical Engineering, Oregon Health and Science University, Portland, Oregon.

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http://dx.doi.org/10.1158/0008-5472.CAN-13-2182DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3934357PMC
January 2014

Breaking the canon: indirect regulation of Wnt signaling in mammary stem cells by MMP3.

Authors:
Mark A LaBarge

Cell Stem Cell 2013 Sep;13(3):259-60

Life Science Division, Lawrence Berkeley National Laboratory, Berkeley, CA 94720, USA.

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http://dx.doi.org/10.1016/j.stem.2013.08.008DOI Listing
September 2013

Processing of human reduction mammoplasty and mastectomy tissues for cell culture.

J Vis Exp 2013 Jan 3(71). Epub 2013 Jan 3.

Life Science Division, Lawrence Berkeley National Laboratory, USA.

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http://dx.doi.org/10.3791/50011DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3582686PMC
January 2013

Programmed cell-to-cell variability in Ras activity triggers emergent behaviors during mammary epithelial morphogenesis.

Cell Rep 2012 Nov 4;2(5):1461-70. Epub 2012 Oct 4.

Department of Pharmaceutical Chemistry, University of California, San Francisco, San Francisco, CA 94158, USA.

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http://dx.doi.org/10.1016/j.celrep.2012.08.037DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3634587PMC
November 2012

Fabrication and use of microenvironment microarrays (MEArrays).

J Vis Exp 2012 Oct 11(68). Epub 2012 Oct 11.

Life Science Division, Lawrence Berkeley National Laboratory, University of California-Berkeley, CA, USA.

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http://dx.doi.org/10.3791/4152DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3490308PMC
October 2012

On stem cells in the human breast.

Authors:
Mark A LaBarge

Cold Spring Harb Perspect Biol 2012 May 1;4(5). Epub 2012 May 1.

Life Science Division, Lawrence Berkeley National Laboratory, Berkeley, California 94720, USA.

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http://dx.doi.org/10.1101/cshperspect.a013441DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3331695PMC
May 2012

Self-organization is a dynamic and lineage-intrinsic property of mammary epithelial cells.

Proc Natl Acad Sci U S A 2011 Feb 7;108(8):3264-9. Epub 2011 Feb 7.

Institute of Bioengineering, Ecole Polytechnique Fédérale de Lausanne, CH-1015 Lausanne, Switzerland.

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http://dx.doi.org/10.1073/pnas.1019556108DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3044373PMC
February 2011

The difficulty of targeting cancer stem cell niches.

Authors:
Mark A LaBarge

Clin Cancer Res 2010 Jun 8;16(12):3121-9. Epub 2010 Jun 8.

Life Science Division, Lawrence Berkeley National Laboratory, Berkeley, CA 94720, USA.

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http://dx.doi.org/10.1158/1078-0432.CCR-09-2933DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3182451PMC
June 2010

Human mammary progenitor cell fate decisions are products of interactions with combinatorial microenvironments.

Integr Biol (Camb) 2009 Jan 12;1(1):70-9. Epub 2008 Nov 12.

Lawrence Berkeley National Laboratory, Division of Life Sciences, Berkeley, CA 94720, USA.

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http://dx.doi.org/10.1039/b816472jDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2933184PMC
January 2009

Is CD133 a marker of metastatic colon cancer stem cells?

J Clin Invest 2008 Jun;118(6):2021-4

Life Sciences Division, Lawrence Berkeley National Laboratory, Berkeley, California 94720, USA.

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http://dx.doi.org/10.1172/JCI36046DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2391070PMC
June 2008

Epithelial-mesenchymal transition and the stem cell phenotype.

Cell Stem Cell 2008 Jun;2(6):511-2

Mayo Clinic Cancer Center, Jacksonville, FL 32224, USA.

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http://dx.doi.org/10.1016/j.stem.2008.05.007DOI Listing
June 2008

Of microenvironments and mammary stem cells.

Stem Cell Rev 2007 Jun;3(2):137-46

Lawrence Berkeley National Laboratory, Berkeley, CA, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3004778PMC
http://dx.doi.org/10.1007/s12015-007-0024-4DOI Listing
June 2007

Evidence for a stem cell hierarchy in the adult human breast.

J Cell Biol 2007 Apr;177(1):87-101

Department of Cellular and Molecular Medicine, Faculty of Health Sciences, and Zoophysiological Laboratory, University of Copenhagen, and Department of Pathology, State University Hospital, Copenhagen, Denmark.

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http://dx.doi.org/10.1083/jcb.200611114DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2064114PMC
April 2007

IGF-I increases bone marrow contribution to adult skeletal muscle and enhances the fusion of myelomonocytic precursors.

J Cell Biol 2005 Nov;171(3):483-92

Department of Molecular Pharmacology, Baxter Laboratory in Genetic Pharmacology, Stanford University School of Medicine, Stanford, CA 94305, USA.

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http://dx.doi.org/10.1083/jcb.200506123DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2171272PMC
November 2005

Bone marrow contribution to skeletal muscle: a physiological response to stress.

Dev Biol 2005 Mar;279(2):336-44

Department of Molecular Pharmacology, Stanford University School of Medicine Stanford, CA 94305, USA.

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http://dx.doi.org/10.1016/j.ydbio.2004.12.024DOI Listing
March 2005

Context, tissue plasticity, and cancer: are tumor stem cells also regulated by the microenvironment?

Cancer Cell 2005 Jan;7(1):17-23

Department Cancer Biology, Life Sciences Division, Lawrence Berkeley National Laboratory, University of California, Berkeley, California 94720, USA.

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http://dx.doi.org/10.1016/j.ccr.2004.12.013DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2933216PMC
January 2005

Hematopoietic contribution to skeletal muscle regeneration by myelomonocytic precursors.

Proc Natl Acad Sci U S A 2004 Sep 7;101(37):13507-12. Epub 2004 Sep 7.

Baxter Laboratory in Genetic Pharmacology and Department of Molecular Pharmacology, Stanford University School of Medicine, 269 Campus Drive, Stanford, CA 94305, USA.

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http://dx.doi.org/10.1073/pnas.0405361101DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC518787PMC
September 2004

Biological progression from adult bone marrow to mononucleate muscle stem cell to multinucleate muscle fiber in response to injury.

Cell 2002 Nov;111(4):589-601

Baxter Laboratory for Genetic Pharmacology, Department of Microbiology and Immunology, Department of Molecular Pharmacology, Stanford University School of Medicine, CCSR 4215, Stanford, CA 94305, USA.

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http://dx.doi.org/10.1016/s0092-8674(02)01078-4DOI Listing
November 2002