Mark I Greene

Mark I Greene

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Mark I Greene

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Foxp3 in Treg cell biology: a molecular and structural perspective.

Clin Exp Immunol 2019 Aug 6. Epub 2019 Aug 6.

Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, 19014, United States.

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http://dx.doi.org/10.1111/cei.13357DOI Listing
August 2019

PRMT5 Associates With the FOXP3 Homomer and When Disabled Enhances Targeted p185 Tumor Immunotherapy.

Front Immunol 2019 8;10:174. Epub 2019 Feb 8.

Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, United States.

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http://dx.doi.org/10.3389/fimmu.2019.00174DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6375878PMC
February 2019

A targeted immunotherapy approach for HER2/neu transformed tumors by coupling an engineered effector domain with interferon-γ.

Oncoimmunology 2018 8;7(4):e1300739. Epub 2018 Feb 8.

Department of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, PA, USA.

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http://dx.doi.org/10.1080/2162402X.2017.1300739DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5889208PMC
February 2018

A spliced form of CD44 expresses the unique glycan that is recognized by the prostate cancer specific antibody F77.

Oncotarget 2018 Jan 16;9(3):3631-3640. Epub 2017 Dec 16.

Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.

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http://dx.doi.org/10.18632/oncotarget.23341DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5790488PMC
January 2018

Suppression by human FOXP3 regulatory T cells requires FOXP3-TIP60 interactions.

Sci Immunol 2017 Jun;2(12)

Department of Microbiology and Immunology, McGill University and Research Institute of McGill University Health Centre, Montréal, Québec H3A 2B4, Canada.

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http://dx.doi.org/10.1126/sciimmunol.aai9297DOI Listing
June 2017

Peter C. Nowell (1928-2016).

Science 2017 03;355(6328):913

Department of Pathology and Laboratory Medicine, Perelman School of Medicine of the University of Pennsylvania, Philadelphia, PA 19104-4238, USA.

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http://dx.doi.org/10.1126/science.aam9738DOI Listing
March 2017

Atomic features of an autoantigen in heparin-induced thrombocytopenia (HIT).

Autoimmun Rev 2016 Jul 9;15(7):752-5. Epub 2016 Mar 9.

Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.

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http://dx.doi.org/10.1016/j.autrev.2016.03.011DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4875785PMC
July 2016

Atomic description of the immune complex involved in heparin-induced thrombocytopenia.

Nat Commun 2015 Sep 22;6:8277. Epub 2015 Sep 22.

Department of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA.

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http://dx.doi.org/10.1038/ncomms9277DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4580983PMC
September 2015

Pim-2 Kinase Influences Regulatory T Cell Function and Stability by Mediating Foxp3 Protein N-terminal Phosphorylation.

J Biol Chem 2015 Aug 18;290(33):20211-20. Epub 2015 May 18.

From the Department of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104,

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http://dx.doi.org/10.1074/jbc.M115.638221DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4536430PMC
August 2015

Multi-crystal native SAD analysis at 6 keV.

Acta Crystallogr D Biol Crystallogr 2014 Oct 30;70(Pt 10):2544-57. Epub 2014 Sep 30.

NYCOMPS, New York Structural Biology Center, New York, NY 10032, USA.

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http://journals.iucr.org/d/issues/2014/10/00/dz5334/dz5334.p
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http://scripts.iucr.org/cgi-bin/paper?S1399004714013376
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http://dx.doi.org/10.1107/S1399004714013376DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4188002PMC
October 2014

Determination of carbohydrate structure recognized by prostate-specific F77 monoclonal antibody through expression analysis of glycosyltransferase genes.

J Biol Chem 2014 Jun 21;289(23):16478-86. Epub 2014 Apr 21.

From the Tumor Microenvironment Program, Cancer Center, Sanford-Burnham Medical Research Institute, La Jolla, California 92037,

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http://dx.doi.org/10.1074/jbc.M114.559047DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4047414PMC
June 2014

Lysosome-dependent p300/FOXP3 degradation and limits Treg cell functions and enhances targeted therapy against cancers.

Exp Mol Pathol 2013 Aug 2;95(1):38-45. Epub 2013 May 2.

Department of Pathology and Lab Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA 19104-6082, USA.

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http://dx.doi.org/10.1016/j.yexmp.2013.04.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3963828PMC
August 2013

Mutations in K-Ras linked to levels of osteoprotegerin and sensitivity to TRAIL-induced cell death in pancreatic ductal adenocarcinoma cells.

Exp Mol Pathol 2013 Apr 5;94(2):372-9. Epub 2012 Dec 5.

Department of Biomedical Sciences, Research Division of Immunology and Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, 8700 Beverly Blvd, Los Angeles, CA 90048, USA.

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http://dx.doi.org/10.1016/j.yexmp.2012.11.003DOI Listing
April 2013

MDM2 regulates a novel form of incomplete neoplastic transformation of Theileria parva infected lymphocytes.

Exp Mol Pathol 2013 Feb 7;94(1):228-38. Epub 2012 Sep 7.

Division of Collaboration and Education, Hokkaido University, Research Center for Zoonosis Control, Sapporo 001-0020, Japan.

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http://dx.doi.org/10.1016/j.yexmp.2012.08.008DOI Listing
February 2013

Structural and biochemical studies of RIG-I antiviral signaling.

Protein Cell 2013 Feb 20;4(2):142-54. Epub 2012 Dec 20.

State Key Laboratory of Cell Biology, Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200031, China.

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http://dx.doi.org/10.1007/s13238-012-2088-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4875364PMC
February 2013

Reversion of the ErbB malignant phenotype and the DNA damage response.

Exp Mol Pathol 2012 Dec 27;93(3):324-33. Epub 2012 Sep 27.

Department of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.

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http://dx.doi.org/10.1016/j.yexmp.2012.09.007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3518600PMC
December 2012

Molecular and biological role of the FOXP3 N-terminal domain in immune regulation by T regulatory/suppressor cells.

Exp Mol Pathol 2012 Dec 2;93(3):334-8. Epub 2012 Oct 2.

Department of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, PA, 19104-6082, USA.

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http://dx.doi.org/10.1016/j.yexmp.2012.09.013DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3518637PMC
December 2012

Germinal center kinases in immune regulation.

Cell Mol Immunol 2012 Nov 10;9(6):439-45. Epub 2012 Sep 10.

Department of Trauma and Orthopaedics, General Hospital of Jinan Military Region, Jinan, China.

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http://202.127.25.143/bitstream/331003/610/1/Yin-2012-Germin
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http://www.nature.com/doifinder/10.1038/cmi.2012.30
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http://dx.doi.org/10.1038/cmi.2012.30DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4002213PMC
November 2012

Structural insights into SUN-KASH complexes across the nuclear envelope.

Cell Res 2012 Oct 4;22(10):1440-52. Epub 2012 Sep 4.

State Key Laboratory of Cell Biology, Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, China.

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http://dx.doi.org/10.1038/cr.2012.126DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3463262PMC
October 2012

Structural and biological features of FOXP3 dimerization relevant to regulatory T cell function.

Cell Rep 2012 Jun 15;1(6):665-75. Epub 2012 Jun 15.

State Key Laboratory of Cell Biology, Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences, Shanghai, China 200031.

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http://dx.doi.org/10.1016/j.celrep.2012.04.012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3401381PMC
June 2012

Efficiency of G2/M-related tumor-associated antigen-targeting cancer immunotherapy depends on antigen expression in the cancer stem-like population.

Exp Mol Pathol 2012 Feb 2;92(1):27-32. Epub 2011 Oct 2.

Department of Pathology, Sapporo Medical University, School of Medicine, South-1 West-17, Chuo-Ku, Sapporo 060-8556, Japan.

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http://dx.doi.org/10.1016/j.yexmp.2011.09.016DOI Listing
February 2012

Structure of Sad1-UNC84 homology (SUN) domain defines features of molecular bridge in nuclear envelope.

J Biol Chem 2012 Feb 14;287(8):5317-26. Epub 2011 Dec 14.

Department of Pathology and Laboratory Medicine, University of Pennsylvania, Perelman School of Medicine, Philadelphia, Pennsylvania 19104, USA.

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http://dx.doi.org/10.1074/jbc.M111.304543DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3285312PMC
February 2012

Structure based antibody-like peptidomimetics.

Pharmaceuticals (Basel) 2012 Feb 16;5(2):209-35. Epub 2012 Feb 16.

Department of Biomedical Sciences, Cedars-Sinai Medical Center, D5091 Davis Building, 8700 Beverly Blvd., Los Angeles, CA 90048, USA.

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http://dx.doi.org/10.3390/ph5020209DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3763629PMC
February 2012

Immune regulation by histone deacetylases: a focus on the alteration of FOXP3 activity.

Immunol Cell Biol 2012 Jan 29;90(1):95-100. Epub 2011 Nov 29.

Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104-6082, USA.

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http://dx.doi.org/10.1038/icb.2011.101DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3366555PMC
January 2012

Expression and function of ErbB receptors and ligands in the pituitary.

Endocr Relat Cancer 2011 Oct 27;18(6):R197-211. Epub 2011 Oct 27.

Department of Medicine, Pituitary Center, Cedars-Sinai Medical Center, Academic Affairs, Room 2015, 8700 Beverly Boulevard, Los Angeles, California 90048, USA.

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http://dx.doi.org/10.1530/ERC-11-0066DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3758362PMC
October 2011

Structural insights into the down-regulation of overexpressed p185(her2/neu) protein of transformed cells by the antibody chA21.

J Biol Chem 2011 Sep 16;286(36):31676-83. Epub 2011 Jun 16.

School of Life Sciences, Hefei National Laboratory for Physical Sciences at Microscale, Chinese Academy of Sciences, University of Science and Technology of China, 96 Jinzhai Road, Hefei, Anhui 230027, China.

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http://www.jbc.org/lookup/doi/10.1074/jbc.M111.235184
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http://dx.doi.org/10.1074/jbc.M111.235184DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3173138PMC
September 2011

Development of anti-EGF receptor peptidomimetics (AERP) as tumor imaging agent.

Bioorg Med Chem Lett 2011 Apr 15;21(8):2550-3. Epub 2011 Feb 15.

Department of Radiology, Cyclotron Facility, 420 Curie Blvd., University of Pennsylvania, Philadelphia, PA 19104, United States.

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http://dx.doi.org/10.1016/j.bmcl.2011.02.013DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3071021PMC
April 2011

Targeting erbB receptors.

Semin Cell Dev Biol 2010 Dec 17;21(9):961-6. Epub 2010 Sep 17.

Department of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, PA 19104-6082, USA.

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https://linkinghub.elsevier.com/retrieve/pii/S10849521100015
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http://dx.doi.org/10.1016/j.semcdb.2010.09.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5940346PMC
December 2010

Histone acetyltransferase mediated regulation of FOXP3 acetylation and Treg function.

Curr Opin Immunol 2010 Oct 24;22(5):583-91. Epub 2010 Sep 24.

Department of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.

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http://dx.doi.org/10.1016/j.coi.2010.08.013DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2967626PMC
October 2010

Regulation of the immune response.

Curr Opin Immunol 2010 Oct 16;22(5):549-51. Epub 2010 Oct 16.

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http://dx.doi.org/10.1016/j.coi.2010.09.004DOI Listing
October 2010

Common genetic variants and modification of penetrance of BRCA2-associated breast cancer.

Authors:
Mia M Gaudet Tomas Kirchhoff Todd Green Joseph Vijai Joshua M Korn Candace Guiducci Ayellet V Segrè Kate McGee Lesley McGuffog Christiana Kartsonaki Jonathan Morrison Sue Healey Olga M Sinilnikova Dominique Stoppa-Lyonnet Sylvie Mazoyer Marion Gauthier-Villars Hagay Sobol Michel Longy Marc Frenay GEMO Study Collaborators Frans B L Hogervorst Matti A Rookus J Margriet Collée Nicoline Hoogerbrugge Kees E P van Roozendaal Marion Piedmonte Wendy Rubinstein Stacy Nerenstone Linda Van Le Stephanie V Blank Trinidad Caldés Miguel de la Hoya Heli Nevanlinna Kristiina Aittomäki Conxi Lazaro Ignacio Blanco Adalgeir Arason Oskar T Johannsson Rosa B Barkardottir Peter Devilee Olofunmilayo I Olopade Susan L Neuhausen Xianshu Wang Zachary S Fredericksen Paolo Peterlongo Siranoush Manoukian Monica Barile Alessandra Viel Paolo Radice Catherine M Phelan Steven Narod Gad Rennert Flavio Lejbkowicz Anath Flugelman Irene L Andrulis Gord Glendon Hilmi Ozcelik Amanda E Toland Marco Montagna Emma D'Andrea Eitan Friedman Yael Laitman Ake Borg Mary Beattie Susan J Ramus Susan M Domchek Katherine L Nathanson Tim Rebbeck Amanda B Spurdle Xiaoqing Chen Helene Holland Esther M John John L Hopper Saundra S Buys Mary B Daly Melissa C Southey Mary Beth Terry Nadine Tung Thomas V Overeem Hansen Finn C Nielsen Mark H Greene Mark I Greene Phuong L Mai Ana Osorio Mercedes Durán Raquel Andres Javier Benítez Jeffrey N Weitzel Judy Garber Ute Hamann Susan Peock Margaret Cook Clare Oliver Debra Frost Radka Platte D Gareth Evans Fiona Lalloo Ros Eeles Louise Izatt Lisa Walker Jacqueline Eason Julian Barwell Andrew K Godwin Rita K Schmutzler Barbara Wappenschmidt Stefanie Engert Norbert Arnold Dorothea Gadzicki Michael Dean Bert Gold Robert J Klein Fergus J Couch Georgia Chenevix-Trench Douglas F Easton Mark J Daly Antonis C Antoniou David M Altshuler Kenneth Offit

PLoS Genet 2010 Oct 28;6(10):e1001183. Epub 2010 Oct 28.

Department of Epidemiology and Population Health and Department of Obstetrics and Gynecology and Women's Health, Albert Einstein College of Medicine, New York, New York, United States of America.

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http://dx.doi.org/10.1371/journal.pgen.1001183DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2965747PMC
October 2010

Nek2 targets the mitotic checkpoint proteins Mad2 and Cdc20: a mechanism for aneuploidy in cancer.

Exp Mol Pathol 2010 Apr 23;88(2):225-33. Epub 2009 Dec 23.

Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, Abramson Family Cancer Research Institute, 252 John Morgan Building, 3600 Hamilton Walk, Philadelphia, PA 19104, USA.

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http://dx.doi.org/10.1016/j.yexmp.2009.12.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2909543PMC
April 2010

Suppression of human prostate tumor growth by a unique prostate-specific monoclonal antibody F77 targeting a glycolipid marker.

Proc Natl Acad Sci U S A 2010 Jan 18;107(2):732-7. Epub 2009 Dec 18.

Department of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, PA 19104-6082, USA.

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http://dx.doi.org/10.1073/pnas.0911397107DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2818935PMC
January 2010

Immunomodulatory effects of deacetylase inhibitors: therapeutic targeting of FOXP3+ regulatory T cells.

Nat Rev Drug Discov 2009 Dec 26;8(12):969-81. Epub 2009 Oct 26.

Division of Transplant Immunology, Children's Hospital of Philadelphia, Philadelphia 19104, USA.

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http://dx.doi.org/10.1038/nrd3031DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2884987PMC
December 2009

Development of Foxp3(+) regulatory t cells is driven by the c-Rel enhanceosome.

Immunity 2009 Dec;31(6):932-40

Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA.

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http://dx.doi.org/10.1016/j.immuni.2009.10.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2807990PMC
December 2009

Deacetylase inhibition increases regulatory T cell function and decreases incidence and severity of collagen-induced arthritis.

Exp Mol Pathol 2009 Oct 3;87(2):99-104. Epub 2009 Jul 3.

Department of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, PA 19104-6082, USA.

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http://dx.doi.org/10.1016/j.yexmp.2009.06.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2753738PMC
October 2009

The role of HER2 in early breast cancer metastasis and the origins of resistance to HER2-targeted therapies.

Exp Mol Pathol 2009 Aug 18;87(1):1-11. Epub 2009 May 18.

Department of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, PA 19104-6082, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2735009PMC
http://dx.doi.org/10.1016/j.yexmp.2009.05.001DOI Listing
August 2009

Structural aspects of the FOXP3 regulatory complex as an immunopharmacological target.

Int Immunopharmacol 2009 May 29;9(5):518-20. Epub 2009 Jan 29.

Department of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, PA 19104-6082, USA.

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http://dx.doi.org/10.1016/j.intimp.2009.01.018DOI Listing
May 2009

FOXP3 and its partners: structural and biochemical insights into the regulation of FOXP3 activity.

Immunol Res 2008 ;42(1-3):19-28

Department of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, PA, 19104-6082, USA.

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http://dx.doi.org/10.1007/s12026-008-8029-xDOI Listing
March 2009

Modulation of biomolecular interactions with complex-binding small molecules.

Methods 2008 Sep 20;46(1):39-46. Epub 2008 Jun 20.

Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, and Abramson Family Cancer Research Institute, 252 John Morgan Building, 3600 Hamilton Walk, Philadelphia, PA 19104, USA.

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http://dx.doi.org/10.1016/j.ymeth.2008.05.008DOI Listing
September 2008

Polymersomes: a new multi-functional tool for cancer diagnosis and therapy.

Methods 2008 Sep 20;46(1):25-32. Epub 2008 Jun 20.

Department of Chemical and Biomolecular Engineering, University of Pennsylvania, Philadelphia, PA 19104-6082, USA.

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http://dx.doi.org/10.1016/j.ymeth.2008.05.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2714227PMC
September 2008

Non-invasive, ultra-sensitive, high-throughput assays to quantify rare biomarkers in the blood.

Methods 2008 Sep 23;46(1):33-8. Epub 2008 Jun 23.

Department of Pathology & Laboratory Medicine, University of Pennsylvania, 252 John Morgan Building, 3620 Hamilton Walk, Philadelphia, PA 19104-6082, USA.

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http://dx.doi.org/10.1016/j.ymeth.2008.05.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2605511PMC
September 2008

TGF-beta and IL-6 signals modulate chromatin binding and promoter occupancy by acetylated FOXP3.

Proc Natl Acad Sci U S A 2008 Sep 8;105(37):14023-7. Epub 2008 Sep 8.

Department of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, PA 19104-6082, USA.

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http://dx.doi.org/10.1073/pnas.0806726105DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2544572PMC
September 2008

Methods. Guest editor's introduction.

Authors:
Mark I Greene

Methods 2008 Sep;46(1)

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http://dx.doi.org/10.1016/j.ymeth.2008.09.021DOI Listing
September 2008

Mechanisms of resistance to ErbB-targeted cancer therapeutics.

J Clin Invest 2008 Jul;118(7):2389-92

Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, and Abramson Family Cancer Research Institute, Philadelphia, Pennsylvania 19104, USA.

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http://dx.doi.org/10.1172/JCI36260DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2430503PMC
July 2008

Human glucocorticoid-induced TNF receptor ligand regulates its signaling activity through multiple oligomerization states.

Proc Natl Acad Sci U S A 2008 Apr 31;105(14):5465-70. Epub 2008 Mar 31.

Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA.

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http://dx.doi.org/10.1073/pnas.0711350105DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2291095PMC
April 2008

Smad3 and NFAT cooperate to induce Foxp3 expression through its enhancer.

Nat Immunol 2008 Feb 23;9(2):194-202. Epub 2007 Dec 23.

Department of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA.

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https://www.mh-hannover.de/fileadmin/institute/immunologie/d
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http://search.proquest.com/openview/3fef705814ba0c5f0cc9bba6
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http://www.nature.com/doifinder/10.1038/ni1549
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http://dx.doi.org/10.1038/ni1549DOI Listing
February 2008

Special regulatory T-cell review: FOXP3 biochemistry in regulatory T cells--how diverse signals regulate suppression.

Immunology 2008 Jan;123(1):17-9

Department of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, PA 19104-6082, USA.

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http://dx.doi.org/10.1111/j.1365-2567.2007.02774.xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2433283PMC
January 2008

Structural basis for ligand-mediated mouse GITR activation.

Proc Natl Acad Sci U S A 2008 Jan 4;105(2):641-5. Epub 2008 Jan 4.

Department of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.

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http://dx.doi.org/10.1073/pnas.0711206105DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2206589PMC
January 2008

CD147 immunoglobulin superfamily receptor function and role in pathology.

Exp Mol Pathol 2007 Dec 7;83(3):283-95. Epub 2007 Sep 7.

University of Pennsylvania, Department of Pathology and Laboratory Medicine, 252 John Morgan Building, 36th & Hamilton Walk, Philadelphia, PA 19104-6082, USA.

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http://dx.doi.org/10.1016/j.yexmp.2007.08.014DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2211739PMC
December 2007

Deacetylase inhibition promotes the generation and function of regulatory T cells.

Nat Med 2007 Nov 7;13(11):1299-307. Epub 2007 Oct 7.

Division of Transplantation Immunology, Department of Pathology and Laboratory Medicine and Biesecker Center for Studies of Pediatric Liver Diseases, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania 19104-4318, USA.

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http://dx.doi.org/10.1038/nm1652DOI Listing
November 2007

Biochemistry and therapeutic implications of mechanisms involved in FOXP3 activity in immune suppression.

Curr Opin Immunol 2007 Oct 20;19(5):583-8. Epub 2007 Aug 20.

Department of Pathology and Laboratory Medicine, University of Pennsylvania, 252 John Morgan Building, 36th and Hamilton Walk, Philadelphia, PA 19104-6082, USA.

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http://dx.doi.org/10.1016/j.coi.2007.07.006DOI Listing
October 2007

Histone deacetylase inhibitors and transplantation.

Curr Opin Immunol 2007 Oct 24;19(5):589-95. Epub 2007 Aug 24.

Division of Transplant Immunology, Department of Pathology and Laboratory Medicine, Children's Hospital of Philadelphia, University of Pennsylvania, Philadelphia, PA 19104-4318, USA.

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http://dx.doi.org/10.1016/j.coi.2007.07.015DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2693068PMC
October 2007

ErbB receptors: from oncogenes to targeted cancer therapies.

J Clin Invest 2007 Aug;117(8):2051-8

Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104-6082, USA.

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http://dx.doi.org/10.1172/JCI32278DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1934579PMC
August 2007

FOXP3 is a homo-oligomer and a component of a supramolecular regulatory complex disabled in the human XLAAD/IPEX autoimmune disease.

Int Immunol 2007 Jul 22;19(7):825-35. Epub 2007 Jun 22.

Department of Pathology and Laboratory Medicine, University of Pennsylvania, 252 John Morgan Building, 36th and Hamilton Walk, Philadelphia, PA 19104-6082, USA.

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http://dx.doi.org/10.1093/intimm/dxm043DOI Listing
July 2007

FOXP3 actively represses transcription by recruiting the HAT/HDAC complex.

Cell Cycle 2007 Jun 10;6(12):1432-6. Epub 2007 May 10.

Department of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA.

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June 2007

FOXP3 interactions with histone acetyltransferase and class II histone deacetylases are required for repression.

Proc Natl Acad Sci U S A 2007 Mar 7;104(11):4571-6. Epub 2007 Mar 7.

Department of Pathology and Laboratory Medicine, University of Pennsylvania, 36th and Hamilton Walk, Philadelphia, PA 19104-6082, USA.

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http://dx.doi.org/10.1073/pnas.0700298104DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1838642PMC
March 2007

Targeted antireceptor therapy with monoclonal antibodies leads to the formation of inactivated tetrameric forms of ErbB receptors.

J Immunol 2007 Jan;178(2):1021-9

Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine and Abramson Family Cancer Research Institute, 36th Hamilton Walk, Philadelphia, PA 19104, USA.

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http://dx.doi.org/10.4049/jimmunol.178.2.1021DOI Listing
January 2007

DIPA, which can localize to the centrosome, associates with p78/MCRS1/MSP58 and acts as a repressor of gene transcription.

Exp Mol Pathol 2006 Dec 2;81(3):184-90. Epub 2006 Oct 2.

Department of Pathology and Laboratory Medicine, 252 John Morgan Building, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA.

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http://linkinghub.elsevier.com/retrieve/pii/S001448000600084
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http://dx.doi.org/10.1016/j.yexmp.2006.07.008DOI Listing
December 2006

Towards comprehensive characterization of HER2 overexpression.

Mol Syst Biol 2006 3;2:55. Epub 2006 Oct 3.

Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine and Abramson Family Cancer Research Institute, Philadelphia, PA, USA.

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http://dx.doi.org/10.1038/msb4100097DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1682019PMC
November 2006

Characterization of the structures involved in localization of the SUN proteins to the nuclear envelope and the centrosome.

DNA Cell Biol 2006 Oct;25(10):554-62

Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA.

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http://www.liebertpub.com/doi/10.1089/dna.2006.25.554
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October 2006

FOXP3 ensembles in T-cell regulation.

Immunol Rev 2006 Aug;212:99-113

Department of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, PA 19104-6082, USA.

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http://dx.doi.org/10.1111/j.0105-2896.2006.00405.xDOI Listing
August 2006

Sialylation regulates peripheral tolerance in CD4+ T cells.

Int Immunol 2006 May 15;18(5):627-35. Epub 2005 Nov 15.

Department of Pathology and Laboratory Medicine, 252 John Morgan Building, 36th & Hamilton Walk, Philadelphia, PA 19104-6082, USA.

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http://dx.doi.org/10.1093/intimm/dxh344DOI Listing
May 2006

A sensitive and high-throughput assay to detect low-abundance proteins in serum.

Nat Med 2006 Apr 12;12(4):473-7. Epub 2006 Mar 12.

Pathology and Laboratory Medicine, School of Medicine, University of Pennsylvania, 3620 Hamilton Walk, Philadelphia, Pennsylvania 19104, USA.

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http://dx.doi.org/10.1038/nm1378DOI Listing
April 2006

Characterization of Su48, a centrosome protein essential for cell division.

Proc Natl Acad Sci U S A 2006 Apr 14;103(17):6512-7. Epub 2006 Apr 14.

Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA.

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http://dx.doi.org/10.1073/pnas.0601682103DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1458915PMC
April 2006

Trastuzumab in breast cancer.

N Engl J Med 2006 Feb;354(6):640-4; author reply 640-4

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February 2006

UXT is a novel centrosomal protein essential for cell viability.

Mol Biol Cell 2005 Dec 12;16(12):5857-65. Epub 2005 Oct 12.

Department of Pathology, University of Pennsylvania, Philadelphia, PA 19104, USA.

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http://dx.doi.org/10.1091/mbc.e05-08-0705DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1289427PMC
December 2005

EGFR enhances Survivin expression through the phosphoinositide 3 (PI-3) kinase signaling pathway.

Exp Mol Pathol 2005 Oct;79(2):100-7

Department of Pathology and Laboratory Medicine, Abramson Family Cancer Research Institute, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA.

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http://dx.doi.org/10.1016/j.yexmp.2005.05.002DOI Listing
October 2005

Differential localization of ErbB receptor ensembles influences their signaling in hippocampal neurons.

DNA Cell Biol 2005 Sep;24(9):553-62

Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, Philadelphia, 19104, USA.

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http://dx.doi.org/10.1089/dna.2005.24.553DOI Listing
September 2005

Disabling TNF receptor signaling by induced conformational perturbation of tryptophan-107.

Proc Natl Acad Sci U S A 2005 Aug 25;102(31):10970-5. Epub 2005 Jul 25.

Department of Pathology and Laboratory of Medicine and Abramson Cancer Research Center, University of Pennsylvania, 36th Hamilton Walk, Philadelphia, PA 19104, USA.

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http://dx.doi.org/10.1073/pnas.0504301102DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1182441PMC
August 2005

Ca(2+) and K(+) (BK) channels in chick hair cells are clustered and colocalized with apical-basal and tonotopic gradients.

J Physiol 2004 Oct 22;560(Pt 1):13-20. Epub 2004 Jul 22.

Department of Neurology, Yale University School of Medicine, 703 LCI Building, 333 Cedar Street, New Haven, CT 06510, USA.

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http://dx.doi.org/10.1113/jphysiol.2004.069856DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1665200PMC
October 2004

The centrosome in normal and transformed cells.

DNA Cell Biol 2004 Aug;23(8):475-89

Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA.

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http://dx.doi.org/10.1089/1044549041562276DOI Listing
August 2004

Fas-disabling small exocyclic peptide mimetics limit apoptosis by an unexpected mechanism.

Proc Natl Acad Sci U S A 2004 Apr 14;101(17):6599-604. Epub 2004 Apr 14.

Department of Pathology and Laboratory Medicine, Abramson Family Cancer Research Institute, University of Pennsylvania School of Medicine, 252 John Morgan Building, 36th and Hamilton Walk, Philadelphia, PA 19104-6082, USA.

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http://dx.doi.org/10.1073/pnas.0401597101DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC404091PMC
April 2004

The TNF receptor superfamily: role in immune inflammation and bone formation.

Immunol Res 2003 ;27(2-3):287-94

Department of Pathology, Abramson Institute for Cancer Research, University of Pennsylvania, Philadelphia, PA 19104-6082, USA.

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http://link.springer.com/10.1385/IR:27:2-3:287
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March 2004

Anergy and suppression as coexistent mechanisms for the maintenance of peripheral T cell tolerance.

Immunol Res 2003 ;27(2-3):295-302

Abramson Family Cancer Research Institute, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA.

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http://dx.doi.org/10.1385/IR:27:2-3:295DOI Listing
March 2004

Structure-based approaches to inhibition of erbB receptors with peptide mimetics.

Immunol Res 2003 ;27(2-3):303-8

Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, and the Abramson Family Cancer Research Institute, Philadelphia, PA 19104, USA.

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http://dx.doi.org/10.1385/IR:27:2-3:303DOI Listing
March 2004

Therapeutic monoclonal antibodies for the ErbB family of receptor tyrosine kinases.

Cancer Biol Ther 2003 Jul-Aug;2(4 Suppl 1):S122-6

Abramson family Cancer Research Institute and the Department of Pathology and Laboratory Medicine, University of Pennsylvania; Philadelphia, Pennsylvania 19104 USA.

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February 2004

Mechanisms of peripheral immune tolerance: conversion of the immune to the unresponsive phenotype.

Immunol Res 2003 ;28(3):193-9

Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine Philadelphia, PA 19104, USA.

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http://dx.doi.org/10.1385/IR:28:3:193DOI Listing
February 2004

Role of extracellular subdomains of p185c-neu and the epidermal growth factor receptor in ligand-independent association and transactivation.

Proc Natl Acad Sci U S A 2003 Aug 16;100(16):9220-5. Epub 2003 Jul 16.

Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA.

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http://dx.doi.org/10.1073/pnas.1633546100DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC170899PMC
August 2003

Disabling receptor ensembles with rationally designed interface peptidomimetics.

J Biol Chem 2002 Aug 14;277(31):28330-9. Epub 2002 May 14.

Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine and the Abramson Family Cancer Research Institute, Philadelphia, Pennsylvania 19104, USA.

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http://dx.doi.org/10.1074/jbc.M202880200DOI Listing
August 2002

Characterization of mouse tGolgin-1 (golgin-245/trans-golgi p230/256 kD golgin) and its upregulation during oligodendrocyte development.

DNA Cell Biol 2002 Jul;21(7):505-17

Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104-6082, USA.

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http://dx.doi.org/10.1089/104454902320219068DOI Listing
July 2002

Fish otolith contains a unique structural protein, otolin-1.

Eur J Biochem 2002 Jan;269(2):688-96

Laboratory of Bioorganic Chemistry, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Japan.

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http://dx.doi.org/10.1046/j.0014-2956.2001.02701.xDOI Listing
January 2002