Publications by authors named "Mark Helm"

99Publications

Stability of Alkyl Chain-Mediated Lipid Anchoring in Liposomal Membranes.

Cells 2020 Sep 29;9(10). Epub 2020 Sep 29.

Institute of Pharmaceutical and Biomedical Science, Johannes Gutenberg-University Mainz, 55128 Mainz, Germany.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3390/cells9102213DOI Listing
September 2020

HydraPsiSeq: a method for systematic and quantitative mapping of pseudouridines in RNA.

Nucleic Acids Res 2020 Sep 25. Epub 2020 Sep 25.

Université de Lorraine, CNRS, INSERM, IBSLor (UMS2008/US40), Epitranscriptomics and RNA Sequencing Core Facility, F54000 Nancy, France.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1093/nar/gkaa769DOI Listing
September 2020

Manganese Ions Individually Alter the Reverse Transcription Signature of Modified Ribonucleosides.

Genes (Basel) 2020 Aug 18;11(8). Epub 2020 Aug 18.

Institute of Pharmaceutical and Biomedical Sciences, Johannes Gutenberg, University Mainz, Staudingerweg 5, 55128 Mainz, Germany.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3390/genes11080950DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7466121PMC
August 2020

Functional characterization of the human tRNA methyltransferases TRMT10A and TRMT10B.

Nucleic Acids Res 2020 06;48(11):6157-6169

Center for Anatomy & Cell Biology, Medical University of Vienna, 1090 Vienna, Austria.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1093/nar/gkaa353DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7293042PMC
June 2020

5-methylcytosine modification of an Epstein-Barr virus noncoding RNA decreases its stability.

RNA 2020 08 30;26(8):1038-1048. Epub 2020 Apr 30.

Department of Microbiology and Molecular Genetics, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15219, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1261/rna.075275.120DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7373997PMC
August 2020

Limited antibody specificity compromises epitranscriptomic analyses.

Nat Commun 2019 12 11;10(1):5669. Epub 2019 Dec 11.

IMoPA, UMR7365 CNRS-University of Lorraine, Biopôle, 9 Avenue de la Forêt de Haye, 54505, Vandœuvre-lès-Nancy, France.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/s41467-019-13684-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6906430PMC
December 2019

Tackling the Limitations of Copolymeric Small Interfering RNA Delivery Agents by a Combined Experimental-Computational Approach.

Biomacromolecules 2019 12 4;20(12):4389-4406. Epub 2019 Nov 4.

Institute of Organic Chemistry and Macromolecular Chemistry , Friedrich Schiller University Jena , Lessingstraße 8 , 07743 Jena , Germany.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1021/acs.biomac.9b01061DOI Listing
December 2019

Against Expectations: Unassisted RNA Adsorption onto Negatively Charged Lipid Bilayers.

Langmuir 2019 11 31;35(45):14704-14711. Epub 2019 Oct 31.

Institute of Pharmacy and Biochemistry , Johannes Gutenberg University , Johann-Joachim-Becherweg 30 , 55128 Mainz , Germany.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1021/acs.langmuir.9b02830DOI Listing
November 2019

Overcoming the barrier of CD8T cells: Two types of nano-sized carriers for siRNA transport.

Acta Biomater 2019 12 4;100:338-351. Epub 2019 Oct 4.

Department of Dermatology, University Medical Center of the Johannes Gutenberg-University Mainz, Langenbeckstr. 1, 55131 Mainz, Germany; Max Planck Institute for Polymer Research, Ackermannweg 10, 55128 Mainz, Germany. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.actbio.2019.10.006DOI Listing
December 2019

FICC-Seq: a method for enzyme-specified profiling of methyl-5-uridine in cellular RNA.

Nucleic Acids Res 2019 11;47(19):e113

Department of Biology and Biochemistry, University of Bath, Claverton Down, Bath, BA2 7AY, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1093/nar/gkz658DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6821191PMC
November 2019

Association between early-childhood antibiotic exposure and subsequent asthma in the US Medicaid population.

Ann Allergy Asthma Immunol 2019 08 31;123(2):186-192.e9. Epub 2019 May 31.

HealthCore Inc, Wilmington, Delaware.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.anai.2019.05.018DOI Listing
August 2019

Surface Modification of Nanoparticles and Nanovesicles via Click-Chemistry.

Methods Mol Biol 2019 ;2000:235-245

Institute of Pharmacy and Biochemistry, Johannes Gutenberg-University, Staudingerweg 5, Mainz, 55126, Germany.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/978-1-4939-9516-5_16DOI Listing
March 2020

Absolute Quantification of Noncoding RNA by Microscale Thermophoresis.

Angew Chem Int Ed Engl 2019 07 2;58(28):9565-9569. Epub 2019 May 2.

Institute of Pharmacy and Biochemistry, Johannes Gutenberg University Mainz, Staudingerweg 5, 55128, Mainz, Germany.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/anie.201814377DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6617968PMC
July 2019

Analysis of the Cellular Roles of MOCS3 Identifies a MOCS3-Independent Localization of NFS1 at the Tips of the Centrosome.

Biochemistry 2019 04 13;58(13):1786-1798. Epub 2019 Mar 13.

Institute of Pharmacy and Biochemistry , Johannes Gutenberg-Universität Mainz , 55128 Mainz , Germany.

View Article

Download full-text PDF

Source
http://pubs.acs.org/doi/10.1021/acs.biochem.8b01160
Publisher Site
http://dx.doi.org/10.1021/acs.biochem.8b01160DOI Listing
April 2019

RNA Modifications Modulate Activation of Innate Toll-Like Receptors.

Genes (Basel) 2019 01 29;10(2). Epub 2019 Jan 29.

Department of Infectious Diseases, Medical Microbiology and Hygiene, Heidelberg University Hospital, 69120 Heidelberg, Germany.

View Article

Download full-text PDF

Source
http://www.mdpi.com/2073-4425/10/2/92
Publisher Site
http://dx.doi.org/10.3390/genes10020092DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6410116PMC
January 2019

Methods for RNA Modification Mapping Using Deep Sequencing: Established and New Emerging Technologies.

Genes (Basel) 2019 01 9;10(1). Epub 2019 Jan 9.

Institute of Pharmacy and Biochemistry, Johannes Gutenberg-University Mainz, Staudingerweg 5, 55128 Mainz, Germany.

View Article

Download full-text PDF

Source
http://www.mdpi.com/2073-4425/10/1/35
Publisher Site
http://dx.doi.org/10.3390/genes10010035DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6356707PMC
January 2019

Mapping and Quantification of tRNA 2'-O-Methylation by RiboMethSeq.

Methods Mol Biol 2019 ;1870:273-295

Next-Generation Sequencing Core Facility, UMS2008 IBSlor, CNRS-UL-INSERM, BioPole Lorraine University, Nancy, France.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/978-1-4939-8808-2_21DOI Listing
May 2019

Determination of enrichment factors for modified RNA in MeRIP experiments.

Methods 2019 03 28;156:102-109. Epub 2018 Oct 28.

Institute of Pharmacy and Biochemistry, Johannes Gutenberg-University Mainz, Germany. Electronic address:

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S10462023183030
Publisher Site
http://dx.doi.org/10.1016/j.ymeth.2018.10.020DOI Listing
March 2019

AlkAniline-Seq: Profiling of m G and m C RNA Modifications at Single Nucleotide Resolution.

Angew Chem Int Ed Engl 2018 12 16;57(51):16785-16790. Epub 2018 Nov 16.

Lorraine University, UMS2008 IBSLor CNRS-UL-INSERM, Biopôle UL, 9, Avenue de la Forêt de Haye, 54505, Vandoeuvre-les-Nancy, France.

View Article

Download full-text PDF

Source
http://doi.wiley.com/10.1002/anie.201810946
Publisher Site
http://dx.doi.org/10.1002/anie.201810946DOI Listing
December 2018

Double methylation of tRNA-U54 to 2'-O-methylthymidine (Tm) synergistically decreases immune response by Toll-like receptor 7.

Nucleic Acids Res 2018 10;46(18):9764-9775

Institute of Pharmacy and Biochemistry, Johannes Gutenberg-University of Mainz, Staudingerweg 5, D-55128 Mainz, Germany.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1093/nar/gky644DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6182150PMC
October 2018

A Vastly Increased Chemical Variety of RNA Modifications Containing a Thioacetal Structure.

Angew Chem Int Ed Engl 2018 06 27;57(26):7893-7897. Epub 2018 Apr 27.

Institute of Pharmacy and Biochemistry, Johannes Gutenberg-University Mainz, Staudingerweg 5, 55128, Mainz, Germany.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/anie.201713188DOI Listing
June 2018

Engineering of a DNA Polymerase for Direct m A Sequencing.

Angew Chem Int Ed Engl 2018 01 7;57(2):417-421. Epub 2017 Dec 7.

Department of Chemistry, Konstanz Research School Chemical Biology, University of Konstanz, Universitätsstraße 10, 78457, Konstanz, Germany.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/anie.201710209DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5768020PMC
January 2018

MODOMICS: a database of RNA modification pathways. 2017 update.

Nucleic Acids Res 2018 01;46(D1):D303-D307

Laboratory of Bioinformatics and Protein Engineering, International Institute of Molecular and Cell Biology in Warsaw, ul. Ks. Trojdena 4, PL-02-109 Warsaw, Poland.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1093/nar/gkx1030DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5753262PMC
January 2018

Principles of Child Health Care Financing.

Pediatrics 2017 Sep 17;140(3). Epub 2017 Jul 17.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1542/peds.2017-2098DOI Listing
September 2017

Editorial: RNA modifications - what to read first?

Authors:
Mark Helm

RNA Biol 2017 09;14(9):1087-1088

a Institute of Pharmacy and Biochemistry, Johannes Gutenberg-University Mainz , Mainz , Germany.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1080/15476286.2017.1358346DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5699551PMC
September 2017

PeptoSomes for Vaccination: Combining Antigen and Adjuvant in Polypept(o)ide-Based Polymersomes.

Macromol Biosci 2017 10 31;17(10). Epub 2017 Jul 31.

Institute of Organic Chemistry, Johannes Gutenberg-University Mainz, Duesbergweg 10-14, 55128, Mainz, Germany.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/mabi.201700061DOI Listing
October 2017

Modulation of Mitochondriotropic Properties of Cyanine Dyes by in Organello Copper-Free Click Reaction.

Chembiochem 2017 09 31;18(18):1814-1818. Epub 2017 Jul 31.

Pharmaceutical Chemistry, Institute of Pharmacy and Biochemistry, Johannes Gutenberg University, Staudinger Weg 5, 55128, Mainz, Germany.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/cbic.201700286DOI Listing
September 2017

Statistically robust methylation calling for whole-transcriptome bisulfite sequencing reveals distinct methylation patterns for mouse RNAs.

Genome Res 2017 09 6;27(9):1589-1596. Epub 2017 Jul 6.

Division of Epigenetics, DKFZ-ZMBH Alliance, German Cancer Research Center, 69120 Heidelberg, Germany.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1101/gr.210666.116DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5580717PMC
September 2017

Identification of an optimized 2'--methylated trinucleotide RNA motif inhibiting Toll-like receptors 7 and 8.

RNA 2017 09 2;23(9):1344-1351. Epub 2017 Jun 2.

Department of Infectious Diseases, Medical Microbiology and Hygiene, Heidelberg University Hospital, 69120 Heidelberg, Germany.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1261/rna.061952.117DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5558904PMC
September 2017

Value-Based Insurance Design Pharmacy Benefits for Children and Youth With Special Health Care Needs: Principles and Opportunities.

Authors:
Mark E Helm

Pediatrics 2017 May;139(Suppl 2):S117-S126

Childhood Health Associates of Salem, Salem, Oregon

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1542/peds.2016-2786FDOI Listing
May 2017

Sulfur transfer and activation by ubiquitin-like modifier system Uba4•Urm1 link protein urmylation and tRNA thiolation in yeast.

Microb Cell 2016 Oct 24;3(11):554-564. Epub 2016 Oct 24.

Universität Kassel, Institut für Biologie, FG Mikrobiologie, Heinrich-Plett-Str. 40, 34132 Kassel, Germany.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.15698/mic2016.11.539DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5349211PMC
October 2016

High-Throughput Mapping of 2'-O-Me Residues in RNA Using Next-Generation Sequencing (Illumina RiboMethSeq Protocol).

Methods Mol Biol 2017 ;1562:171-187

IMoPA UMR7365 CNRS-UL, BioPole Lorraine University, 9 Avenue de la Foret de Haye, 54505, Vandoeuvre-Les-Nancy, France.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/978-1-4939-6807-7_12DOI Listing
February 2018

LC-MS Analysis of Methylated RNA.

Methods Mol Biol 2017 ;1562:3-18

Institute of Pharmacy and Biochemistry, Johannes Gutenberg-University of Mainz, Staudingerweg 5, 55099, Mainz, Germany.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/978-1-4939-6807-7_1DOI Listing
February 2018

Alkyne-Functionalized Coumarin Compound for Analytic and Preparative 4-Thiouridine Labeling.

Bioconjug Chem 2017 04 15;28(4):1123-1134. Epub 2017 Mar 15.

Institute of Pharmacy and Biochemistry, Johannes-Gutenberg University Mainz , Staudingerweg 5, D-55128 Mainz, Germany.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1021/acs.bioconjchem.7b00035DOI Listing
April 2017

Detecting RNA modifications in the epitranscriptome: predict and validate.

Nat Rev Genet 2017 05 20;18(5):275-291. Epub 2017 Feb 20.

IMoPA UMR7365 CNRS-UL, BioPole Lorraine University, 9 avenue de la Foret de Haye, 54505 Vandoeuvre-les-Nancy, France.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/nrg.2016.169DOI Listing
May 2017

Next-Generation Sequencing-Based RiboMethSeq  Protocol for Analysis of tRNA 2'-O-Methylation.

Biomolecules 2017 02 9;7(1). Epub 2017 Feb 9.

IMoPA UMR7365 CNRS-UL, Biopole Lorraine University, 54505 Vandoeuvre-les-Nancy, France.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3390/biom7010013DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5372725PMC
February 2017

mA modulates neuronal functions and sex determination in Drosophila.

Nature 2016 12 30;540(7632):242-247. Epub 2016 Nov 30.

Institute of Molecular Biology (IMB), 55128 Mainz, Germany.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/nature20568DOI Listing
December 2016

CoverageAnalyzer (CAn): A Tool for Inspection of Modification Signatures in RNA Sequencing Profiles.

Biomolecules 2016 11 10;6(4). Epub 2016 Nov 10.

Institute of Pharmacy and Biochemistry, Johannes Gutenberg University Mainz, Staudingerweg 5, 55128 Mainz, Germany.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3390/biom6040042DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5197952PMC
November 2016

DNA and RNA Pyrimidine Nucleobase Alkylation at the Carbon-5 Position.

Adv Exp Med Biol 2016 ;945:19-33

Institute of Pharmacy and Biochemistry, Johannes Gutenberg University Mainz, Staudingerweg 5, 55128, Mainz, Germany.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/978-3-319-43624-1_2DOI Listing
June 2017

The RNA methyltransferase Dnmt2 methylates DNA in the structural context of a tRNA.

RNA Biol 2017 09 7;14(9):1241-1251. Epub 2016 Nov 7.

a Institute of Pharmacy and Biochemistry, Johannes Gutenberg University Mainz , Mainz , Germany.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1080/15476286.2016.1236170DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5699543PMC
September 2017

Diastereoselectivity of 5-Methyluridine Osmylation Is Inverted inside an RNA Chain.

Bioconjug Chem 2016 09 1;27(9):2188-97. Epub 2016 Sep 1.

Institute of Pharmacy and Biochemistry, University of Mainz , D-55128 Mainz, Germany.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1021/acs.bioconjchem.6b00403DOI Listing
September 2016

Orthogonal Click Conjugation to the Liposomal Surface Reveals the Stability of the Lipid Anchorage as Crucial for Targeting.

Chemistry 2016 Aug 12;22(33):11578-82. Epub 2016 Jul 12.

Institute of Pharmacy and Biochemistry, Johannes Gutenberg-University Mainz, Staudingerweg 5, 55128, Mainz, Germany.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/chem.201602758DOI Listing
August 2016

Illumina-based RiboMethSeq approach for mapping of 2'-O-Me residues in RNA.

Nucleic Acids Res 2016 09 14;44(16):e135. Epub 2016 Jun 14.

IMoPA UMR7365 CNRS-UL, BioPole Lorraine University, 9 avenue de la Foret de Haye, 54505 Vandoeuvre-les-Nancy, France Next-Generation Sequencing Core Facility, FR3209 BMCT, Lorraine University, 9 avenue de la Foret de Haye, 54505 Vandoeuvre-les-Nancy, France

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1093/nar/gkw547DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5027498PMC
September 2016

Stability of a Split Streptomycin Binding Aptamer.

J Phys Chem B 2016 07 24;120(27):6479-89. Epub 2016 Jun 24.

Max Planck Institute for Polymer Research , 55128 Mainz, Germany.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1021/acs.jpcb.6b02440DOI Listing
July 2016

Mechanism and biological role of Dnmt2 in Nucleic Acid Methylation.

RNA Biol 2017 09 27;14(9):1108-1123. Epub 2016 May 27.

h Institut für Pharmazie und Biochemie, Johannes Gutenberg-Universität Mainz , Mainz , Germany.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1080/15476286.2016.1191737DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5699548PMC
September 2017

Analysis of RNA modifications by liquid chromatography-tandem mass spectrometry.

Methods 2016 09 25;107:48-56. Epub 2016 Mar 25.

Institute of Pharmacy and Biochemistry, Johannes Gutenberg-University of Mainz, Staudingerweg 5, 55099 Mainz, Germany. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.ymeth.2016.03.019DOI Listing
September 2016

High-throughput sequencing for 1-methyladenosine (m(1)A) mapping in RNA.

Methods 2016 09 24;107:110-21. Epub 2016 Feb 24.

IMoPA UMR7365 CNRS-UL, BioPole Lorraine University, 9 avenue de la Foret de Haye, 54505 Vandoeuvre-les-Nancy, France; Next-Generation Sequencing Core Facility, FR3209 BMCT, Lorraine University, 9 avenue de la Foret de Haye, 54505 Vandoeuvre-les-Nancy, France. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.ymeth.2016.02.012DOI Listing
September 2016

GADD45a physically and functionally interacts with TET1.

Differentiation 2015 Jul-Oct;90(1-3):59-68. Epub 2015 Nov 3.

Institute of Molecular Biology, 55128 Mainz, Germany. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.diff.2015.10.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4673086PMC
June 2016

The marbled crayfish as a paradigm for saltational speciation by autopolyploidy and parthenogenesis in animals.

Biol Open 2015 Oct 30;4(11):1583-94. Epub 2015 Oct 30.

Division of Epigenetics, DKFZ-ZMBH Alliance, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 580, 69120 Heidelberg, Germany

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1242/bio.014241DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4728364PMC
October 2015

Dynamic modulation of Dnmt2-dependent tRNA methylation by the micronutrient queuine.

Nucleic Acids Res 2015 Dec 30;43(22):10952-62. Epub 2015 Sep 30.

Institut für Biologie, Humboldt-Universität zu Berlin, 10115 Berlin, Germany

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1093/nar/gkv980DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4678861PMC
December 2015

Variable presence of 5-methylcytosine in commercial RNA and DNA.

RNA Biol 2015 14;12(10):1152-8. Epub 2015 Aug 14.

a Institute of Pharmacy and Biochemistry; Johannes Gutenberg-University of Mainz ; Mainz , Germany.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1080/15476286.2015.1076612DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4829282PMC
May 2016

Recognition of Specified RNA Modifications by the Innate Immune System.

Methods Enzymol 2015 22;560:73-89. Epub 2015 Jul 22.

Institute of Pharmacy and Biochemistry, Johannes Gutenberg-University of Mainz, Mainz, Germany. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/bs.mie.2015.03.006DOI Listing
May 2016

Intermolecular 'cross-torque': the N4-cytosine propargyl residue is rotated to the 'CH'-edge as a result of Watson-Crick interaction.

Nucleic Acids Res 2015 Jun 30;43(11):5275-83. Epub 2015 Apr 30.

Department of Pharmaceutical Chemistry, Institute of Pharmacy and Biochemistry, Johannes Gutenberg University, 55128 Mainz, Rhineland-Palatinate, Germany

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1093/nar/gkv285DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4477647PMC
June 2015

Live cell imaging of duplex siRNA intracellular trafficking.

Nucleic Acids Res 2015 May 13;43(9):4650-60. Epub 2015 Apr 13.

Institute of Pharmacy and Biochemistry, University of Mainz, D-55128 Mainz, Germany Institute of Pharmacy und Molecular Biotechnology, University of Heidelberg, D-69120 Heidelberg, Germany

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1093/nar/gkv307DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4482072PMC
May 2015

2'-O-Methylation within Bacterial RNA Acts as Suppressor of TLR7/TLR8 Activation in Human Innate Immune Cells.

J Innate Immun 2015 20;7(5):482-93. Epub 2015 Mar 20.

Department of Infectious Diseases, Medical Microbiology and Hygiene, University of Heidelberg, Heidelberg, Germany.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1159/000375460DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6738864PMC
June 2016

Urmylation and tRNA thiolation functions of ubiquitin-like Uba4·Urm1 systems are conserved from yeast to man.

FEBS Lett 2015 Apr 3;589(8):904-9. Epub 2015 Mar 3.

Universität Kassel, Institut für Biologie, FG Mikrobiologie, Heinrich-Plett-Str. 40, 34132 Kassel, Germany. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.febslet.2015.02.024DOI Listing
April 2015

Pseudouridine: still mysterious, but never a fake (uridine)!

RNA Biol 2014 ;11(12):1540-54

a Institute of Pharmacy and Biochemistry ; Johannes Gutenberg-University of Mainz ; Mainz , Germany.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.4161/15476286.2014.992278DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4615568PMC
October 2015

Phosphorylation of Elp1 by Hrr25 is required for elongator-dependent tRNA modification in yeast.

PLoS Genet 2015 Jan 8;11(1):e1004931. Epub 2015 Jan 8.

Centre for Gene Regulation & Expression, College of Life Sciences, University of Dundee, Dundee, United Kingdom.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1371/journal.pgen.1004931DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4287497PMC
January 2015

Cytosine methylation of tRNA-Asp by DNMT2 has a role in translation of proteins containing poly-Asp sequences.

Cell Discov 2015 9;1:15010. Epub 2015 Jun 9.

Institute of Biochemistry, Stuttgart University, Faculty of Chemistry , Stuttgart, Germany.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/celldisc.2015.10DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4860778PMC
July 2016

New Techniques to Assess In Vitro Release of siRNA from Nanoscale Polyplexes.

Pharm Res 2015 Jun 9;32(6):1957-74. Epub 2014 Dec 9.

Institute of Pharmacy and Biochemistry, Johannes Gutenberg-University Mainz, Staudinger Weg 5, 55128, Mainz, Germany.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s11095-014-1589-7DOI Listing
June 2015

New Techniques to Assess In Vitro Release of siRNA from Nanoscale Polyplexes.

Pharm Res 2015 Jun 9;32(6):1957-74. Epub 2014 Dec 9.

Institute of Pharmacy and Biochemistry, Johannes Gutenberg-University Mainz, Staudinger Weg 5, 55128, Mainz, Germany.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s11095-014-1589-7DOI Listing
June 2015

Absolute and relative quantification of RNA modifications via biosynthetic isotopomers.

Nucleic Acids Res 2014 Oct 16;42(18):e142. Epub 2014 Aug 16.

Institute of Pharmacy and Biochemistry, Johannes Gutenberg University Mainz, 55099 Mainz, Germany

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1093/nar/gku733DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4191383PMC
October 2014

A modified dinucleotide motif specifies tRNA recognition by TLR7.

RNA 2014 Sep 22;20(9):1351-5. Epub 2014 Jul 22.

Institute of Pharmacy and Biochemistry, Johannes Gutenberg-University Mainz, 55128 Mainz, Germany.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1261/rna.044024.113DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4138318PMC
September 2014

Click modification of multifunctional liposomes bearing hyperbranched polyether chains.

Biomacromolecules 2014 Jul 26;15(7):2440-8. Epub 2014 Jun 26.

Institute of Pharmacy and Biochemistry, Johannes Gutenberg-University Mainz , Staudingerweg 5, 55122 Mainz, Germany.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1021/bm5003027DOI Listing
July 2014

Synthesis of new asymmetric xanthene dyes via catalyst-free S(N)Ar with sulfur nucleophiles.

Org Biomol Chem 2014 Jun;12(23):3816-20

Institute of Pharmacy and Biochemistry, Johannes Gutenberg-University Mainz, Staudingerweg 5, D-55128 Mainz, Germany.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1039/c4ob00533cDOI Listing
June 2014

The guanidinium group as a key part of water-soluble polymer carriers for siRNA complexation and protection against degradation.

Macromol Rapid Commun 2014 Jul 4;35(13):1191-7. Epub 2014 Apr 4.

Max Planck Institute for Polymer Research, Ackermannweg 10, 55128, Mainz, Germany.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/marc.201400120DOI Listing
July 2014

Profiling of RNA modifications by multiplexed stable isotope labelling.

Chem Commun (Camb) 2014 Apr 24;50(26):3516-8. Epub 2014 Feb 24.

Institute of Pharmacy and Biochemistry, Johannes Gutenberg University, 5 Staudinger Weg, Mainz, D-55128, Germany.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1039/c3cc49114eDOI Listing
April 2014

Posttranscriptional RNA Modifications: playing metabolic games in a cell's chemical Legoland.

Chem Biol 2014 Feb 5;21(2):174-85. Epub 2013 Dec 5.

Department of Microbiology and The Center for RNA Biology, The Ohio State University, Columbus, OH 43210, USA; Ohio State Biochemistry Program, The Ohio State University, Columbus, OH 43210, USA. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.chembiol.2013.10.015DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3944000PMC
February 2014

MODOMICS: a database of RNA modification pathways--2013 update.

Nucleic Acids Res 2013 Jan 30;41(Database issue):D262-7. Epub 2012 Oct 30.

Laboratory of Bioinformatics and Protein Engineering, International Institute of Molecular and Cell Biology, ul. Ks. Trojdena 4, PL-02-109 Warsaw, Poland.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1093/nar/gks1007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3531130PMC
January 2013

A modified guanosine phosphoramidite for click functionalization of RNA on the sugar edge.

Chem Commun (Camb) 2012 Nov;48(89):11014-6

Institute of Pharmacy and Biochemistry, Johannes Gutenberg University, 5 Staudinger Weg, Mainz, D-55128, Germany.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1039/c2cc34015aDOI Listing
November 2012

RNA cytosine methylation by Dnmt2 and NSun2 promotes tRNA stability and protein synthesis.

Nat Struct Mol Biol 2012 Sep 12;19(9):900-5. Epub 2012 Aug 12.

Division of Epigenetics, Deutsches Krebsforschungszentrum, Heidelberg, Germany.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/nsmb.2357DOI Listing
September 2012

Dye selection for live cell imaging of intact siRNA.

Biol Chem 2012 Jan;393(1-2):23-35

Institute of Pharmacy and Molecular Biotechnology, Heidelberg University, Im Neuenheimer Feld 364, D-69120 Heidelberg, Germany.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1515/BC-2011-256DOI Listing
January 2012

RNA mediated Toll-like receptor stimulation in health and disease.

RNA Biol 2012 Jun 23;9(6):828-42. Epub 2012 May 23.

Heidelberg University, Department of Infectious Diseases - Medical Microbiology and Hygiene, Im Neuenheimer Feld 324, Heidelberg 69120, Germany.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.4161/rna.20206DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3495747PMC
June 2012

Mapping the tRNA binding site on the surface of human DNMT2 methyltransferase.

Biochemistry 2012 Jun 23;51(22):4438-44. Epub 2012 May 23.

Biochemistry Laboratory, School of Engineering and Science, Jacobs University Bremen, Campus Ring 1, 28759 Bremen, Germany.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1021/bi3002659DOI Listing
June 2012

Related haloarchaeal pleomorphic viruses contain different genome types.

Nucleic Acids Res 2012 Jul 6;40(12):5523-34. Epub 2012 Mar 6.

Department of Biosciences and Institute of Biotechnology, University of Helsinki, P.O. Box 56, FIN-00014 University of Helsinki, Finland.

View Article

Download full-text PDF

Source
https://academic.oup.com/nar/article-lookup/doi/10.1093/nar/
Publisher Site
http://dx.doi.org/10.1093/nar/gks215DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3384331PMC
July 2012

Cationic nanohydrogel particles as potential siRNA carriers for cellular delivery.

ACS Nano 2012 Mar 2;6(3):2198-214. Epub 2012 Mar 2.

Institute of Organic Chemistry, Johannes Gutenberg-University Mainz, Staudingerweg 5, D-55099 Mainz, Germany.

View Article

Download full-text PDF

Source
http://pubs.acs.org/doi/10.1021/nn204116u
Publisher Site
http://dx.doi.org/10.1021/nn204116uDOI Listing
March 2012