Mark Hannink

Mark Hannink

UNVERIFIED PROFILE

Are you Mark Hannink?   Register this Author

Register author
Mark Hannink

Mark Hannink

Publications by authors named "Mark Hannink"

Are you Mark Hannink?   Register this Author

47Publications

643Reads

43Profile Views

Exploring the molecular genetic foundations of cancer biology and how biomedical advances are made in an advanced undergraduate course.

Biochem Mol Biol Educ 2019 07 15;47(4):408-416. Epub 2019 Apr 15.

Department of Biochemistry, University of Missouri, Columbia, Missouri, 65211.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/bmb.21247DOI Listing
July 2019

Assembly of PGAM5 into Multimeric Complexes Provides a Mechanism for Allosteric Regulation of Phosphatase Activity.

Methods Enzymol 2018 23;607:353-372. Epub 2018 Jun 23.

University of Missouri, Columbia, MO, United States.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/bs.mie.2018.05.017DOI Listing
June 2019

HDAC5 catalytic activity suppresses cardiomyocyte oxidative stress and NRF2 target gene expression.

J Biol Chem 2019 05 8;294(21):8640-8652. Epub 2019 Apr 8.

From the Department of Medicine, Division of Cardiology and Consortium for Fibrosis Research & Translation and

View Article

Download full-text PDF

Source
http://www.jbc.org/lookup/doi/10.1074/jbc.RA118.007006
Publisher Site
http://dx.doi.org/10.1074/jbc.RA118.007006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6544848PMC
May 2019

Docosahexaenoic acid (DHA): An essential nutrient and a nutraceutical for brain health and diseases.

Prostaglandins Leukot Essent Fatty Acids 2018 09 10;136:3-13. Epub 2017 Mar 10.

Department of Radiology, Neurology, and Psychological Sciences, and the Thompson Center, William and Nancy Thompson Endowed Chair in Radiology, University of Missouri School of Medicine, Columbia, MO, United States.

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S09523278163021
Publisher Site
http://dx.doi.org/10.1016/j.plefa.2017.03.006DOI Listing
September 2018

Withania somnifera and Its Withanolides Attenuate Oxidative and Inflammatory Responses and Up-Regulate Antioxidant Responses in BV-2 Microglial Cells.

Neuromolecular Med 2016 Sep 21;18(3):241-52. Epub 2016 May 21.

Biochemistry Department, University of Missouri, 117 Schweitzer Hall, Columbia, MO, 65211, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s12017-016-8411-0DOI Listing
September 2016

Phytochemicals and botanical extracts regulate NF-κB and Nrf2/ARE reporter activities in DI TNC1 astrocytes.

Neurochem Int 2016 07 7;97:49-56. Epub 2016 May 7.

Biochemistry Department, University of Missouri, Columbia, MO, USA; Center for Botanical Interaction Studies, University of Missouri, Columbia, MO, USA. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.neuint.2016.05.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4900906PMC
July 2016

Quercetin Attenuates Inflammatory Responses in BV-2 Microglial Cells: Role of MAPKs on the Nrf2 Pathway and Induction of Heme Oxygenase-1.

PLoS One 2015 27;10(10):e0141509. Epub 2015 Oct 27.

Biochemistry Department, University of Missouri, Columbia, Missouri, United States of America; Center for Botanical Interaction Studies, University of Missouri, Columbia, Missouri, United States of America.

View Article

Download full-text PDF

Source
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0141509PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4624710PMC
June 2016

From Gigabyte to Kilobyte: A Bioinformatics Protocol for Mining Large RNA-Seq Transcriptomics Data.

PLoS One 2015 22;10(4):e0125000. Epub 2015 Apr 22.

Computer Science Department, University of Missouri, Columbia, Missouri, United States of America; MU Botanical Center, University of Missouri, Columbia, Missouri, United States of America; Informatics Institute, University of Missouri, Columbia, Missouri, United States of America; C. Bond Life Science Center, University of Missouri, Columbia, Missouri, United States of America.

View Article

Download full-text PDF

Source
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0125000PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4406561PMC
April 2016

Proteomic analysis of the effects of aged garlic extract and its FruArg component on lipopolysaccharide-induced neuroinflammatory response in microglial cells.

PLoS One 2014 24;9(11):e113531. Epub 2014 Nov 24.

Department of Pathology and Anatomical Sciences, University of Missouri School of Medicine, Columbia, Missouri, United States of America; Center for Translational Neuroscience, University of Missouri School of Medicine, Columbia, Missouri, United States of America; Harry S. Truman Veterans Hospital, Columbia, Missouri, United States of America.

View Article

Download full-text PDF

Source
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0113531PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4242640PMC
January 2016

piggyBac transposon plus insulators overcome epigenetic silencing to provide for stable signaling pathway reporter cell lines.

PLoS One 2013 20;8(12):e85494. Epub 2013 Dec 20.

Department of Biochemistry, University of Missouri, Columbia, Missouri, United States of America ; Experiment Station Chemical Labs, University of Missouri, Columbia, Missouri, United States of America ; Department of Child Health, University of Missouri, Columbia, Missouri, United States of America.

View Article

Download full-text PDF

Source
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0085494PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3869926PMC
October 2014

A conserved motif mediates both multimer formation and allosteric activation of phosphoglycerate mutase 5.

J Biol Chem 2014 Sep 10;289(36):25137-48. Epub 2014 Jul 10.

From the Bond Life Sciences Center and the Department of Biochemistry, University of Missouri, Columbia, Missouri 65211

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1074/jbc.M114.565549DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4155678PMC
September 2014

Gold nanoparticle-mediated detection of circulating cancer cells.

Clin Lab Med 2012 Mar;32(1):89-101

Department of Biological Engineering, University of Missouri, Columbia, MO 65212, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.cll.2012.01.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3285417PMC
March 2012

Effects of interventions on oxidative stress and inflammation of cardiovascular diseases.

World J Cardiol 2011 Jan;3(1):18-24

Sewon Lee, Yoonjung Park, Mozow Yusof Zuidema, Cuihua Zhang, Department of Internal Medicine, Medical Pharmacology and Physiology and Nutritional Sciences, Dalton Cardiovascular Research Center, University of Missouri, Columbia, MO 65211, United States.

View Article

Download full-text PDF

Source
http://www.wjgnet.com/1949-8462/full/v3/i1/18.htm
Publisher Site
http://dx.doi.org/10.4330/wjc.v3.i1.18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3030733PMC
January 2011

Dihydro-CDDO-trifluoroethyl amide (dh404), a novel Nrf2 activator, suppresses oxidative stress in cardiomyocytes.

PLoS One 2009 Dec 21;4(12):e8391. Epub 2009 Dec 21.

Department of Cell Biology and Anatomy, University of South Carolina School of Medicine, Columbia, South Carolina, USA.

View Article

Download full-text PDF

Source
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0008391PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2791441PMC
December 2009

Ceramide synthase 1 is regulated by proteasomal mediated turnover.

Biochim Biophys Acta 2009 Jul 22;1793(7):1218-27. Epub 2009 Apr 22.

Division of Biological Sciences, University of Missouri, Columbia, MO 65211, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.bbamcr.2009.04.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2724657PMC
July 2009

Cul3-mediated Nrf2 ubiquitination and antioxidant response element (ARE) activation are dependent on the partial molar volume at position 151 of Keap1.

Biochem J 2009 Jul 29;422(1):171-80. Epub 2009 Jul 29.

Center for Pharmaceutical Biotechnology and the Department of Medicinal Chemistry and Pharmacognosy, University of Illinois, Chicago, IL 60607, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1042/BJ20090471DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3865926PMC
July 2009

Identification of oxygen-sensitive transcriptional programs in human embryonic stem cells.

Stem Cells Dev 2008 Oct;17(5):869-81

Department of Animal Sciences, University of Missouri, Columbia, Missouri 65211-7310, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1089/scd.2007.0240DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3189708PMC
October 2008

PGAM5 tethers a ternary complex containing Keap1 and Nrf2 to mitochondria.

Exp Cell Res 2008 May 5;314(8):1789-803. Epub 2008 Mar 5.

Department of Biochemistry, University of Missouri - Columbia, Columbia, MO 65212, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.yexcr.2008.02.014DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2409987PMC
May 2008

Fiber type-specific nitric oxide protects oxidative myofibers against cachectic stimuli.

PLoS One 2008 May 7;3(5):e2086. Epub 2008 May 7.

Department of Medicine, Duke University Medical Center, Durham, North Carolina, United States of America.

View Article

Download full-text PDF

Source
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0002086PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2361191PMC
May 2008

Molecular imaging of bcl-2 expression in small lymphocytic lymphoma using 111In-labeled PNA-peptide conjugates.

J Nucl Med 2008 Mar 20;49(3):430-8. Epub 2008 Feb 20.

Department of Veterinary Medicine and Surgery, University of Missouri-Columbia, Columbia, Missouri 65211, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.2967/jnumed.107.045138DOI Listing
March 2008

ERRbeta: a potent inhibitor of Nrf2 transcriptional activity.

Mol Cell Endocrinol 2007 Nov 31;278(1-2):52-62. Epub 2007 Aug 31.

Department of Experimental Radiation Oncology, University of Texas, M.D. Anderson Cancer Center, Houston, TX 77030, United States.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.mce.2007.08.011DOI Listing
November 2007

Nitric oxide stimulates heme oxygenase-1 gene transcription via the Nrf2/ARE complex to promote vascular smooth muscle cell survival.

Cardiovasc Res 2007 Jul 12;75(2):381-9. Epub 2007 Mar 12.

Department of Medical Pharmacology and Physiology, University of Missouri, Columbia, MO 65212, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.cardiores.2007.03.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1994113PMC
July 2007

Disruption of the Keap1-containing ubiquitination complex as an antioxidant therapy.

Curr Top Med Chem 2007 ;7(10):972-8

Neuroscience Drug Discovery, Merck Research Laboratories, Merck and Co., Inc., 770 Sumneytown Pike, PO Box 4, West Point, PA 19486, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.2174/156802607780906825DOI Listing
July 2007

PGAM5, a Bcl-XL-interacting protein, is a novel substrate for the redox-regulated Keap1-dependent ubiquitin ligase complex.

J Biol Chem 2006 Dec 17;281(49):37893-903. Epub 2006 Oct 17.

Department of Biochemistry, University of Missouri, Columbia, Missouri 65211, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1074/jbc.M606539200DOI Listing
December 2006

Structure of the Keap1:Nrf2 interface provides mechanistic insight into Nrf2 signaling.

EMBO J 2006 Aug 3;25(15):3605-17. Epub 2006 Aug 3.

Department of Biochemistry, University of Missouri-Columbia, Columbia, MO 65211, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/sj.emboj.7601243DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1538563PMC
August 2006

CAND1-mediated substrate adaptor recycling is required for efficient repression of Nrf2 by Keap1.

Mol Cell Biol 2006 Feb;26(4):1235-44

Department of Biochemistry, Life Science Center, M121 Medical Sciences Building, University of Missouri-Columbia, Columbia, MO 65212, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1128/MCB.26.4.1235-1244.2006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1367193PMC
February 2006

Conserved solvent and side-chain interactions in the 1.35 Angstrom structure of the Kelch domain of Keap1.

Acta Crystallogr D Biol Crystallogr 2005 Oct 28;61(Pt 10):1335-42. Epub 2005 Sep 28.

Department of Biochemistry, University of Missouri-Columbia, Columbia, MO 65211, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1107/S0907444905022626DOI Listing
October 2005

Distinct signaling pathways for induction of type II NOS by IFNgamma and LPS in BV-2 microglial cells.

Neurochem Int 2005 Sep;47(4):298-307

Department of Nutritional Sciences, University of Missouri, Columbia, MO 65212, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.neuint.2005.03.007DOI Listing
September 2005

Ubiquitination of Keap1, a BTB-Kelch substrate adaptor protein for Cul3, targets Keap1 for degradation by a proteasome-independent pathway.

J Biol Chem 2005 Aug 27;280(34):30091-9. Epub 2005 Jun 27.

Department of Biochemistry, University of Missouri, Columbia, Missouri 65212, USA.

View Article

Download full-text PDF

Source
http://www.jbc.org/lookup/doi/10.1074/jbc.M501279200
Publisher Site
http://dx.doi.org/10.1074/jbc.M501279200DOI Listing
August 2005

Coordinate regulation of basal and cyclic 5'-adenosine monophosphate (cAMP)-activated expression of human chorionic gonadotropin-alpha by Ets-2 and cAMP-responsive element binding protein.

Mol Endocrinol 2005 Apr 6;19(4):1049-66. Epub 2005 Jan 6.

Department of Animal Sciences, University of Missouri, Columbia, Missouri 65211-7310, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1210/me.2004-0320DOI Listing
April 2005

Crystal structure of the Kelch domain of human Keap1.

J Biol Chem 2004 Dec 8;279(52):54750-8. Epub 2004 Oct 8.

Department of Biochemistry, University of Misouri-Columbia, Misouri 65211, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1074/jbc.M410073200DOI Listing
December 2004

Keap1 is a redox-regulated substrate adaptor protein for a Cul3-dependent ubiquitin ligase complex.

Mol Cell Biol 2004 Dec;24(24):10941-53

Department of Biochemistry, University of Missouri-Columbia, M121 Medical Sciences Building, Columbia, MO 65212, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1128/MCB.24.24.10941-10953.2004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC533977PMC
December 2004

Crystallization and initial crystallographic analysis of the Kelch domain from human Keap1.

Acta Crystallogr D Biol Crystallogr 2004 Dec 26;60(Pt 12 Pt 2):2346-8. Epub 2004 Nov 26.

Department of Biochemistry, University of Missouri-Columbia, Columbia, MO 65211, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1107/S0907444904024825DOI Listing
December 2004

Synthesis of radiometal-labeled and fluorescent cell-permeating peptide-PNA conjugates for targeting the bcl-2 proto-oncogene.

Bioconjug Chem 2003 Nov-Dec;14(6):1083-95

Molecular Biology Program, University of Missouri-Columbia, Columbia, Missouri 65211, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1021/bc034084nDOI Listing
July 2004

Nrf2 is a direct PERK substrate and effector of PERK-dependent cell survival.

Mol Cell Biol 2003 Oct;23(20):7198-209

The Leonard and Madlyn Abramson Family Cancer Research Institute and Cancer Center, Department of Cancer Biology, University of Pennsylvania Cancer Center, Philadelphia, Pennsylvania 19104, USA.

View Article

Download full-text PDF

Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC230321PMC
http://dx.doi.org/10.1128/mcb.23.20.7198-7209.2003DOI Listing
October 2003

Molecular mechanisms that regulate transcription factor localization suggest new targets for drug development.

Adv Drug Deliv Rev 2003 Jun;55(6):717-31

Department of Biochemistry, M121 Medical Sciences Building, University of Missouri, Columbia, MO 65212, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/s0169-409x(03)00052-8DOI Listing
June 2003

Radiometal-labeled peptide-PNA conjugates for targeting bcl-2 expression: preparation, characterization, and in vitro mRNA binding.

Bioconjug Chem 2002 Nov-Dec;13(6):1176-80

Department of Veterinary Medicine and Surgery, University of Missouri Research Reactor, Columbia, Missouri 65211, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1021/bc025591sDOI Listing
May 2003

CRM1-mediated nuclear export is present during porcine embryogenesis, but is not required for early cleavage.

Biol Reprod 2002 Sep;67(3):814-9

Department of Animal Sciences, University of Missouri, 162 Animal Science Research Center, Columbia, Missouri 65211, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1095/biolreprod.102.004960DOI Listing
September 2002

Characterization of the nuclear import and export functions of Ikappa B(epsilon).

J Biol Chem 2002 Jun 22;277(26):23358-66. Epub 2002 Apr 22.

Biochemistry Department University of Missouri, Columbia, Missouri 65212, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1074/jbc.M111559200DOI Listing
June 2002