Mark H Menzen

Smooth-muscle-derived WNT5A augments allergen-induced airway remodelling and Th2 type inflammation.

Authors:

Tim Koopmans Laura Hesse Martijn C Nawijn Kuldeep Kumawat Mark H Menzen I Sophie T Bos Ron Smits Elvira R M Bakker Maarten van den Berge Gerard H Koppelman Victor Guryev Reinoud Gosens

Sci Rep 2020 04 21;10(1):6754. Epub 2020 Apr 21.

Department of Molecular Pharmacology, University of Groningen, Groningen, The Netherlands.

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April 2020

Elastase-Induced Parenchymal Disruption and Airway Hyper Responsiveness in Mouse Precision Cut Lung Slices: Toward an COPD Model.

Authors:

Eline M Van Dijk Sule Culha Mark H Menzen Cécile M Bidan Reinoud Gosens

Front Physiol 2016 4;7:657. Epub 2017 Jan 4.

Department of Molecular Pharmacology, University of GroningenGroningen, Netherlands; Groningen Research Institute for Asthma and COPD, University Medical Center Groningen, University of GroningenGroningen, Netherlands.

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January 2017

Selective targeting of CREB-binding protein/β-catenin inhibits growth of and extracellular matrix remodelling by airway smooth muscle.

Authors:

Tim Koopmans Stijn Crutzen Mark H Menzen Andrew J Halayko Tillie-Louise Hackett Darryl A Knight Reinoud Gosens

Br J Pharmacol 2016 12 25;173(23):3327-3341. Epub 2016 Oct 25.

Department of Molecular Pharmacology, University of Groningen, Groningen, The Netherlands.

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December 2016

Cooperative signaling by TGF-β1 and WNT-11 drives sm-α-actin expression in smooth muscle via Rho kinase-actin-MRTF-A signaling.

Authors:

Kuldeep Kumawat Tim Koopmans Mark H Menzen Alita Prins Marieke Smit Andrew J Halayko Reinoud Gosens

Am J Physiol Lung Cell Mol Physiol 2016 09 15;311(3):L529-37. Epub 2016 Jul 15.

Department of Molecular Pharmacology, University of Groningen, Groningen, the Netherlands; Groningen Research Institute for Asthma and COPD, University of Groningen, the Netherlands; and

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September 2016

Noncanonical WNT-5B signaling induces inflammatory responses in human lung fibroblasts.

Authors:

Eline M van Dijk Mark H Menzen Anita I R Spanjer Laurens D C Middag Corry-Anke A Brandsma Reinoud Gosens

Am J Physiol Lung Cell Mol Physiol 2016 06 1;310(11):L1166-76. Epub 2016 Apr 1.

Department of Molecular Pharmacology, University of Groningen, Groningen, the Netherlands; Groningen Research Institute for Asthma and Chronic Obstructive Pulmonary Disease, University Medical Center, Groningen, University of Groningen, Groningen, the Netherlands.

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June 2016

Combination therapy of tiotropium and ciclesonide attenuates airway inflammation and remodeling in a guinea pig model of chronic asthma.

Authors:

Loes E M Kistemaker I Sophie T Bos Mark H Menzen Harm Maarsingh Herman Meurs Reinoud Gosens

Respir Res 2016 Feb 4;17:13. Epub 2016 Feb 4.

Department of Molecular Pharmacology, University of Groningen, A. Deusinglaan 1, 9713 AV, Groningen, The Netherlands.

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February 2016

A pro-inflammatory role for the Frizzled-8 receptor in chronic bronchitis.

Authors:

Anita I R Spanjer Mark H Menzen Akkelies E Dijkstra Maarten van den Berge H Marike Boezen David C Nickle Don D Sin Yohan Bossé Corry-Anke Brandsma Wim Timens Dirkje S Postma Herman Meurs Irene H Heijink Reinoud Gosens

Thorax 2016 Apr 21;71(4):312-22. Epub 2016 Jan 21.

Department of Molecular Pharmacology, University of Groningen, Groningen, The Netherlands Groningen Research Institute for Asthma and COPD (GRIAC), University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.

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April 2016

L-thyroxine promotes a proliferative airway smooth muscle phenotype in the presence of TGF-β1.

Authors:

Bart G J Dekkers Saeideh Naeimi I Sophie T Bos Mark H Menzen Andrew J Halayko Goudarz Sadeghi Hashjin Herman Meurs

Am J Physiol Lung Cell Mol Physiol 2015 Feb 5;308(3):L301-6. Epub 2014 Dec 5.

Department of Molecular Pharmacology, University of Groningen, Groningen, The Netherlands; Groningen Research Institute for Asthma and COPD, University of Groningen, Groningen, The Netherlands;

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February 2015

TGF-β-activated kinase 1 (TAK1) signaling regulates TGF-β-induced WNT-5A expression in airway smooth muscle cells via Sp1 and β-catenin.

Authors:

Kuldeep Kumawat Mark H Menzen Ralph M Slegtenhorst Andrew J Halayko Martina Schmidt Reinoud Gosens

PLoS One 2014 11;9(4):e94801. Epub 2014 Apr 11.

Department of Molecular Pharmacology, University of Groningen, Groningen, the Netherlands; Groningen Research Institute for Asthma and COPD, University of Groningen, Groningen, the Netherlands.

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May 2015