Publications by authors named "Mark G Lewis"

100Publications

Evaluation of the mRNA-1273 Vaccine against SARS-CoV-2 in Nonhuman Primates.

N Engl J Med 2020 10 28;383(16):1544-1555. Epub 2020 Jul 28.

From the Vaccine Research Center (K.S.C., B. Flynn, K.E.F., J.R.F., S.B.-B., A.P.W., B. Flach, S. O'Connell, A.T.N., N.D., M.M.D., N.N.N., G.S.A., D.R.F., E.L., N.A.D.-R., B.C.L., M.K.L., S. O'Dell, S.D.S., E.P., L.A.C., C.Y., J.-P.M.T., W.S., Y.Z., O.M.A., L.W., A.P., E.S.Y., K.L., T.Z., I.-T.T., A.W., I.G., L.N., R.A.G., R.J.L., J.I.M., W.-P.K., K.M.M., T.J.R., J.E.L., M.R.G., P.D.K., J.R.M., A.M., N.J.S., M.R., R.A.S., B.S.G.), the Infectious Disease Pathogenesis Section (K.W.B., M.M., B.M.N., M.G.L.), and the Biostatistics Research Branch, Division of Clinical Research (M.C.N.), National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, and Bioqual (H.A., L.P., A.V.R., S.B., J.G., T.P.-T., A.S., T.-A.C., A. Cook, A.D., K.S., I.N.M.) and the Public Health Service Commissioned Corps (M.R.G.), Rockville - both in Maryland; the Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill (D.R.M., R.S.B.); Moderna, Cambridge, MA (D.K.E., G.S.-J., S.H., A. Carfi); and the Institute for Biomedical Sciences, George Washington University, Washington, DC (E.P.).

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October 2020

Prevention of SIVmac251 reservoir seeding in rhesus monkeys by early antiretroviral therapy.

Nat Commun 2018 12 21;9(1):5429. Epub 2018 Dec 21.

Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, 02215, USA.

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December 2018

Chronic simian immunodeficiency virus infection is associated with contrasting phenotypes of dysfunctional Bcl6 germinal center B cells or Bcl6 Bcl2 non-germinal center B cells.

J Cell Mol Med 2018 11 6;22(11):5682-5687. Epub 2018 Sep 6.

F. Edward Hébert School of Medicine, Uniformed Services University, Bethesda, Maryland.

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November 2018

Zika convalescent macaques display delayed induction of anamnestic cross-neutralizing antibody responses after dengue infection.

Emerg Microbes Infect 2018 07 13;7(1):130. Epub 2018 Jul 13.

F. Edward Hébert School of Medicine, Uniformed Services University, Bethesda, MD, USA.

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July 2018

Fetal Neuropathology in Zika Virus-Infected Pregnant Female Rhesus Monkeys.

Cell 2018 05 29;173(5):1111-1122.e10. Epub 2018 Mar 29.

Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA; Ragon Institute of MGH, MIT, and Harvard, Cambridge, MA 02139, USA. Electronic address:

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May 2018

Zika Virus Persistence in the Central Nervous System and Lymph Nodes of Rhesus Monkeys.

Cell 2017 05 27;169(4):610-620.e14. Epub 2017 Apr 27.

Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA; Ragon Institute of MGH, MIT, and Harvard, Cambridge, MA 02139, USA. Electronic address:

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May 2017

Characterization of founder viruses in very early SIV rectal transmission.

Virology 2017 02 25;502:97-105. Epub 2016 Dec 25.

Nebraska Center for Virology, School of Biological Sciences, University of Nebraska-Lincoln, Lincoln, NE, USA. Electronic address:

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February 2017

Neutralizing antibody affords comparable protection against vaginal and rectal simian/human immunodeficiency virus challenge in macaques.

AIDS 2016 06;30(10):1543-51

aDepartment of Immunology and Microbial Science, IAVI Neutralizing Antibody Center and Center for HIV/AIDS Vaccine Immunology and Immunogen Discovery, The Scripps Research Institute, La Jolla, California bEmory Vaccine Center and Yerkes National Primate Research Center, Emory University, Atlanta, Georgia cCenter for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts dBioqual, Inc., Rockville, Maryland eBioinformatics and Systems Biology Program, Sanford Burnham Prebys Medical Discovery Institute, La Jolla, California, USA fGenmab, Utrecht, The Netherlands gRagon Institute of MGH, MIT, and Harvard, Cambridge, Massachusetts, USA. *Present address: MedImmune, LLC, Gaithersburg, Maryland, USA.

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June 2016

Effect of chronic morphine administration on circulating dendritic cells in SIV-infected rhesus macaques.

J Neuroimmunol 2016 06 16;295-296:30-40. Epub 2016 Apr 16.

Center for Inflammation, Translational and Clinical Lung Research, USA. Electronic address:

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June 2016

The Influence of Risk Perceptions and Efficacy Beliefs on Leisure-Time Physical Activity During Pregnancy.

J Phys Act Health 2016 05 28;13(5):494-503. Epub 2015 Oct 28.

Dept of Educational Leadership, Sports Studies, and Educational Counseling Psychology, Washington State University, Pullman, WA.

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May 2016

SIV Infection of Lung Macrophages.

PLoS One 2015 1;10(5):e0125500. Epub 2015 May 1.

Nebraska Center for Virology, School of Biological Sciences, University of Nebraska-Lincoln, Lincoln, Nebraska, United States of America.

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February 2016

Type I interferon upregulates Bak and contributes to T cell loss during human immunodeficiency virus (HIV) infection.

PLoS Pathog 2013 10;9(10):e1003658. Epub 2013 Oct 10.

Department of Microbiology and Immunology, Center for Immunology and Vaccine Science, Drexel University College of Medicine, Philadelphia, Pennsylvania, United States of America.

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May 2014

Effect of chronic morphine administration on circulating T cell population dynamics in rhesus macaques.

J Neuroimmunol 2013 Dec 20;265(1-2):43-50. Epub 2013 Sep 20.

Center for Inflammation, Translational and Clinical Lung Research, 3500 N. Broad Street, Temple University School of Medicine, Philadelphia, PA 19140, USA.

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December 2013

Rhesus macaque lymph node PD-1(hi)CD4+ T cells express high levels of CXCR5 and IL-21 and display a CCR7(lo)ICOS+Bcl6+ T-follicular helper (Tfh) cell phenotype.

PLoS One 2013 19;8(3):e59758. Epub 2013 Mar 19.

Uniformed Services University of the Health Sciences, Bethesda, Maryland, United States of America.

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September 2013

IL-15 delays suppression and fails to promote immune reconstitution in virally suppressed chronically SIV-infected macaques.

Blood 2011 Sep 14;118(9):2520-9. Epub 2011 Jul 14.

ImmunoTechnology Section, Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA.

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September 2011

High antibody and cellular responses induced to HIV-1 clade C envelope following DNA vaccines delivered by electroporation.

Vaccine 2011 Sep 31;29(39):6763-70. Epub 2010 Dec 31.

Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, 422 Curie Blvd, 505 SCL, Philadelphia, PA 19104, USA.

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September 2011

Phosphorothioate 2' deoxyribose oligomers as microbicides that inhibit human immunodeficiency virus type 1 (HIV-1) infection and block Toll-like receptor 7 (TLR7) and TLR9 triggering by HIV-1.

Antimicrob Agents Chemother 2010 Oct 12;54(10):4064-73. Epub 2010 Jul 12.

Department of Microbiology and Immunology, Center for Immunology and Vaccine Science, Drexel University College of Medicine, Philadelphia, Pennsylvania 19129, USA.

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October 2010

IL-28B/IFN-lambda 3 drives granzyme B loading and significantly increases CTL killing activity in macaques.

Mol Ther 2010 Sep 22;18(9):1714-23. Epub 2010 Jun 22.

Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA.

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September 2010

Systemic immunization with CCL27/CTACK modulates immune responses at mucosal sites in mice and macaques.

Vaccine 2010 Feb;28(8):1942-51

Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA 19104-6100, United States.

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February 2010

Viral reservoir is suppressed but not eliminated by CD8 vaccine specific lymphocytes.

Vaccine 2010 Feb;28(8):1924-31

Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, 422 Curie Blvd., Philadelphia, PA 19104, United States.

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February 2010

A virus-like particle vaccine for epidemic Chikungunya virus protects nonhuman primates against infection.

Nat Med 2010 Mar 28;16(3):334-8. Epub 2010 Jan 28.

Vaccine Research Center, National Institute of Allergy and Infectious Diseases, US National Institutes of Health, Bethesda, Maryland, USA.

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March 2010

CD8+ cell depletion of SHIV89.6P-infected macaques induces CD4+ T cell proliferation that contributes to increased viral loads.

J Immunol 2009 Oct 28;183(8):5006-12. Epub 2009 Sep 28.

Department of Microbiology and Immunology, and Center for Immunology and Vaccine Sciences, Drexel University College of Medicine, Philadelphia, PA 19129, USA.

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October 2009

High dose of plasmid IL-15 inhibits immune responses in an influenza non-human primates immunogenicity model.

Virology 2009 Oct 15;393(1):49-55. Epub 2009 Aug 15.

Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, 505 SCL, 422 Curie Blvd. Philadelphia, PA 19104, USA.

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October 2009

Early divergence in neutrophil apoptosis between pathogenic and nonpathogenic simian immunodeficiency virus infections of nonhuman primates.

J Immunol 2008 Dec;181(12):8613-23

Faculté de Médecine, Service d'Immunologie et d'Hématologie,Assistance Publique-Hôpitaux de Paris, Centre Hospitalier Universitaire Xavier Bichat, Université Paris 7-Denis Diderot, Paris, France.

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December 2008

Sustained suppression of SHIV89.6P replication in macaques by vaccine-induced CD8+ memory T cells.

AIDS 2008 Sep;22(14):1739-48

Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA.

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September 2008

Concentrations of dapivirine in the rhesus macaque and rabbit following once daily intravaginal administration of a gel formulation of [14C]dapivirine for 7 days.

Antimicrob Agents Chemother 2008 Mar 17;52(3):909-14. Epub 2007 Dec 17.

International Partnership for Microbicides, 8401 Colesville Road, Suite 200, Silver Spring, MD 20910, USA.

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March 2008

Early establishment and antigen dependence of simian immunodeficiency virus-specific CD8+ T-cell defects.

J Virol 2007 Oct 1;81(20):10861-8. Epub 2007 Aug 1.

Department of Microbiology and Immunology, Drexel University College of Medicine, 2900 Queen Lane, Philadelphia, PA 19129, USA.

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October 2007

DNA encoding an HIV-1 Gag/human lysosome-associated membrane protein-1 chimera elicits a broad cellular and humoral immune response in Rhesus macaques.

PLoS One 2006 Dec 27;1:e135. Epub 2006 Dec 27.

Department of Pharmacology and Molecular Sciences, Johns Hopkins School of Medicine, Baltimore, Maryland, United States of America.

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December 2006

Anti-HIV-1 immunotoxin 3B3(Fv)-PE38: enhanced potency against clinical isolates in human PBMCs and macrophages, and negligible hepatotoxicity in macaques.

J Leukoc Biol 2006 Nov 21;80(5):1175-82. Epub 2006 Aug 21.

Laboratory of Viral Diseases, NIAID, National Institutes of Health Building 4, Room 237 Bethesda, MD 20892, USA.

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November 2006

Independence of granzyme B secretion and interferon- gamma production during acute simian immunodeficiency virus infection.

J Infect Dis 2006 May 14;193(10):1441-50. Epub 2006 Apr 14.

Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, Philadelphia 19104-6100, USA.

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May 2006

Rhesus macaques with high levels of vaccine induced IFN-gamma producing cells better control viral set-point following challenge with SIV239.

Vaccine 2006 May 18;24(21):4498-502. Epub 2005 Aug 18.

Department of Pathology and Laboratory Medicine, 505 Stellar-Chance Laboratories, 422 Curie Boulevard, University of Pennsylvania School of Medicine, Philadelphia, PA 19104-6100, USA.

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May 2006