Mark F Cotton

Mark F Cotton

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HIV outbreak in children in Pakistan: localised or more widespread?

Lancet Infect Dis 2020 Mar 19;20(3):269-270. Epub 2019 Dec 19.

Department of Paediatrics and Child Health, Faculty of Medicine and Health Sciences, Stellenbosch University, Tygerberg 7505, South Africa; Department of Paediatrics and Child Health, Tygerberg Hospital, Tygerbeg, South Africa.

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http://dx.doi.org/10.1016/S1473-3099(19)30746-7DOI Listing
March 2020

Effect of HIV-exposure and timing of antiretroviral treatment initiation in children living with HIV on antibody persistence and memory responses to Haemophilus influenzae type b and pneumococcal polysaccharide-protein conjugate vaccines.

Vaccine 2020 Mar 15;38(12):2651-2659. Epub 2020 Feb 15.

Medical Research Council: Respiratory and Meningeal Pathogens Research Unit, University of the Witwatersrand, Faculty of Health Sciences, Johannesburg, South Africa; Department of Science/National Research Foundation: Vaccine Preventable Diseases, University of the Witwatersrand, Faculty of Health Science, Johannesburg, South Africa.

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http://dx.doi.org/10.1016/j.vaccine.2020.02.026DOI Listing
March 2020

Earlier Antiretroviral Therapy Initiation and Decreasing Mortality Among HIV-infected Infants Initiating Antiretroviral Therapy Within 3 Months of Age in South Africa, 2006-2017.

Pediatr Infect Dis J 2020 Feb;39(2):127-133

From the Centre for Infectious Disease Epidemiology and Research, School of Public Health and Family Medicine, Faculty of Health Sciences, University of Cape Town Medicine, Cape Town, South Africa.

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http://dx.doi.org/10.1097/INF.0000000000002516DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7073445PMC
February 2020

Disclosure of human immunodeficiency virus status to children in South Africa: A comprehensive analysis.

South Afr J HIV Med 2019 22;20(1):884. Epub 2019 Aug 22.

Department of Paediatric Infectious Diseases and Immunology, Amsterdam University Medical Center, Vrije Universiteit Amsterdam, Amsterdam, the Netherlands.

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http://dx.doi.org/10.4102/sajhivmed.v20i1.884DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6739545PMC
August 2019

Is point-of-care early infant HIV diagnosis sustainable?

Lancet HIV 2019 Jun 12;6(6):e344-e345. Epub 2019 Apr 12.

Family Centre for Research with Ubuntu (FAM-CRU), Department of Paediatrics and Child Health, Faculty of Medicine and Health Sciences, Stellenbosch University, Cape Town 8000, South Africa.

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https://linkinghub.elsevier.com/retrieve/pii/S23523018193007
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http://dx.doi.org/10.1016/S2352-3018(19)30078-5DOI Listing
June 2019

What Will It Take to Implement Targeted HIV Testing at Birth?

Pediatrics 2019 06 17;143(6). Epub 2019 May 17.

Family Center for Research with Ubuntu, Tygerberg Children's Hospital and Stellenbosch University, Cape Town, South Africa.

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http://dx.doi.org/10.1542/peds.2019-0913DOI Listing
June 2019

Human Immunodeficiency Virus-exposed Uninfected Infants: Surviving and Thriving or Overlooked by Success?

Clin Infect Dis 2019 05;68(12):2156-2158

Division of Infectious Diseases and Family Clinical Research Unit, Department of Paediatrics and Child Health, Faculty of Medicine and Health Sciences, Stellenbosch University, Tygerberg, South Africa.

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http://dx.doi.org/10.1093/cid/ciy1056DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6769231PMC
May 2019

Should efavirenz be used in children and, if so, how?

Lancet HIV 2019 Apr 12;6(4):e210-e211. Epub 2019 Feb 12.

Department of Paediatrics and Child Health FAM-CRU, Faculty of Medicine and Health Sciences, Stellenbosch University, Cape Town, South Africa.

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http://dx.doi.org/10.1016/S2352-3018(18)30337-0DOI Listing
April 2019

Tuberculosis and HIV-An Update on the "Cursed Duet" in Children.

Front Pediatr 2019 25;7:159. Epub 2019 Apr 25.

Family Centre for Research with Ubuntu (FAM-CRU), Department of Paediatrics and Child Health, Faculty of Medicine and Health Sciences, Stellenbosch University, Stellenbosch, South Africa.

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http://dx.doi.org/10.3389/fped.2019.00159DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7073470PMC
April 2019

Paediatric ART Adherence in South Africa: A Comprehensive Analysis.

AIDS Behav 2019 Feb;23(2):475-488

Department of Paediatric Infectious Diseases and Immunology, VU University Medical Centre, Amsterdam, The Netherlands.

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http://dx.doi.org/10.1007/s10461-018-2235-xDOI Listing
February 2019

Insulin Resistance in South African Youth Living with Perinatally Acquired HIV Receiving Antiretroviral Therapy.

AIDS Res Hum Retroviruses 2019 01 25;35(1):56-62. Epub 2018 Sep 25.

1 Department of Paediatrics and Child Health, Research Centre for Adolescent and Child Health University of Cape Town, Cape Town, South Africa.

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https://www.liebertpub.com/doi/10.1089/aid.2018.0092
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http://dx.doi.org/10.1089/AID.2018.0092DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6343194PMC
January 2019

Effect of HIV exposure and timing of antiretroviral therapy initiation on immune memory responses to diphtheria, tetanus, whole cell pertussis and hepatitis B vaccines.

Expert Rev Vaccines 2019 01 19;18(1):95-104. Epub 2018 Nov 19.

a Department of Science and Technology, Health Sciences , National Research Foundation:Vaccine Preventable Diseases University of the Witwatersrand , Johannesburg , South Africa.

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https://www.tandfonline.com/doi/full/10.1080/14760584.2019.1
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http://dx.doi.org/10.1080/14760584.2019.1547195DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6842654PMC
January 2019

Considerations in evaluating infectious morbidity and mortality in HIV-exposed uninfected infants.

AIDS 2018 11;32(18):2855-2856

Department of Paediatrics & Child Health, Faculty of Medicine & Health Sciences, Stellenbosch University, Worcester, Western Cape, South Africa.

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http://Insights.ovid.com/crossref?an=00002030-201811280-0002
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http://dx.doi.org/10.1097/QAD.0000000000002049DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6363822PMC
November 2018

High Incidence of Tuberculosis Infection in HIV-exposed Children Exiting an Isoniazid Preventive Therapy Trial.

Pediatr Infect Dis J 2018 10;37(10):e254-e256

Department of Paediatrics and Child Health, Desmond Tutu TB Centre, Faculty of Medicine and Health Sciences, Stellenbosch University, Tygerberg, Cape Town, South Africa.

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http://Insights.ovid.com/crossref?an=00006454-201810000-0002
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http://dx.doi.org/10.1097/INF.0000000000001946DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6095832PMC
October 2018

A treatment-support intervention evaluated in South African paediatric populations with HIV infection or tuberculous meningitis.

Trop Med Int Health 2018 10 3;23(10):1129-1140. Epub 2018 Sep 3.

Department of Pediatric Infectious Diseases and Immunology, Amsterdam UMC, Vrije Universiteit, Amsterdam, The Netherlands.

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http://dx.doi.org/10.1111/tmi.13134DOI Listing
October 2018

Early Breastfeeding Cessation Among HIV-Infected and HIV-Uninfected Women in Western Cape Province, South Africa.

AIDS Behav 2018 Jul;22(Suppl 1):114-120

Department of Paediatrics & Child Health, Stellenbosch University, Francie van Zijl Drive, Cape Town, 8000, South Africa.

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http://dx.doi.org/10.1007/s10461-018-2208-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6091631PMC
July 2018

Perinatal HIV Infection or Exposure Is Associated With Low -Acetylaspartate and Glutamate in Basal Ganglia at Age 9 but Not 7 Years.

Front Hum Neurosci 2018 7;12:145. Epub 2018 May 7.

Medical Imaging Research Unit, Division of Biomedical Engineering, Department of Human Biology, Faculty of Health Sciences, University of Cape Town, Cape Town, South Africa.

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http://dx.doi.org/10.3389/fnhum.2018.00145DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5949349PMC
May 2018

Altered brain morphometry in 7-year old HIV-infected children on early ART.

Metab Brain Dis 2018 04 5;33(2):523-535. Epub 2017 Dec 5.

MRC/UCT Medical Imaging Research Unit, Division of Biomedical Engineering, Department of Human Biology, Faculty of Health Sciences, University of Cape Town, Cape Town, South Africa.

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http://dx.doi.org/10.1007/s11011-017-0162-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5866746PMC
April 2018

Favourable outcome in a child with symptomatic diagnosis of Glutaric aciduria type 1 despite vertical HIV infection and minor head trauma.

Metab Brain Dis 2018 04 9;33(2):537-544. Epub 2018 Feb 9.

Family Clinical Research Unit, Department of Paediatrics and Child Health, Tygerberg Hospital and Stellenbosch University, Francie van Zijl Drive, Tygerberg, Cape Town, South Africa.

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http://dx.doi.org/10.1007/s11011-018-0196-4DOI Listing
April 2018

Update on trends in childhood tuberculosis.

Curr Opin Pediatr 2018 02;30(1):152-160

Family Infectious Diseases Clinical Research Unit, Stellenbosch University, Cape Town, South Africa.

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http://dx.doi.org/10.1097/MOP.0000000000000581DOI Listing
February 2018

Functional Connectivity Alterations between Networks and Associations with Infant Immune Health within Networks in HIV Infected Children on Early Treatment: A Study at 7 Years.

Front Hum Neurosci 2017 11;11:635. Epub 2018 Jan 11.

MRC/UCT Medical Imaging Research Unit, Division of Biomedical Engineering, Department of Human Biology, Faculty of Health Sciences, University of Cape Town, Cape Town, South Africa.

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http://dx.doi.org/10.3389/fnhum.2017.00635DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5768628PMC
January 2018

Late-Onset Hiv Encephalopathy In Children With Long-Standing Virologic Suppression Followed By Slow Spontaneous Recovery Despite no Change In Antiretroviral Therapy: 4 Case Reports.

Pediatr Infect Dis J 2017 Nov;36(11):e264-e267

From the *Children's Infectious Diseases Clinical Research Unit (KID-CRU), Stellenbosch University, and †Department of Paediatrics and Child Health, Tygerberg Children's Hospital, Cape Town, South Africa; ‡Perinatal HIV Research Unit, Faculty of Health Sciences, University of the Witwatersrand, Soweto, South Africa; and §Division of Medical Virology, Stellenbosch University and Tygerberg Academic Hospital, Cape Town, South Africa.

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http://dx.doi.org/10.1097/INF.0000000000001694DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5638699PMC
November 2017

Use of Multiplex Quantitative PCR To Evaluate the Impact of Pneumococcal Conjugate Vaccine on Nasopharyngeal Pneumococcal Colonization in African Children.

mSphere 2017 Nov-Dec;2(6). Epub 2017 Nov 8.

Department of Science and Technology/National Research Foundation, Vaccine Preventable Diseases, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa.

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http://dx.doi.org/10.1128/mSphere.00404-17DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5677981PMC
November 2017

Larger Subcortical Gray Matter Structures and Smaller Corpora Callosa at Age 5 Years in HIV Infected Children on Early ART.

Front Neuroanat 2017 2;11:95. Epub 2017 Nov 2.

MRC/UCT Medical Imaging Research Unit, Division of Biomedical Engineering, Department of Human Biology, Faculty of Health Sciences, University of Cape Town, Cape Town, South Africa.

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http://dx.doi.org/10.3389/fnana.2017.00095DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5673662PMC
November 2017

Longitudinal increases of brain metabolite levels in 5-10 year old children.

PLoS One 2017 11;12(7):e0180973. Epub 2017 Jul 11.

MRC/UCT Medical Imaging Research Unit, Division of Biomedical Engineering, Faculty of Health Sciences, University of Cape Town, Observatory, Cape Town, South Africa.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0180973PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5507439PMC
September 2017

White Matter Abnormalities in Children with HIV Infection and Exposure.

Front Neuroanat 2017 29;11:88. Epub 2017 Sep 29.

Division of Biomedical Engineering, Department of Human Biology, University of Cape Town, Cape Town, South Africa.

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http://dx.doi.org/10.3389/fnana.2017.00088DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5627060PMC
September 2017

Antiretroviral Treatment Initiated in the First Month of Life.

Pediatr Infect Dis J 2017 06;36(6):584-587

From the *Division of Paediatric Infectious Diseases and Department of Paediatrics and Child Health, Tygerberg Children's Hospital, Faculty of Medicine and Health Sciences, Stellenbosch University, Stellenbosch, South Africa; †School of Medicine, Imperial College London, London, United Kingdom; ‡Division of Medical Virology, Department of Pathology, Stellenbosch University and the National Health Laboratory Service, Tygerberg Hospital, Cape Town, South Africa; and §Division of Neonatology and Department of Paediatrics and Child Health, Tygerberg Children's Hospital, Faculty of Medicine and Health Sciences, Stellenbosch University, Stellenbosch, South Africa.

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http://dx.doi.org/10.1097/INF.0000000000001504DOI Listing
June 2017

Placental pathology in HIV infection at term: a comparison with HIV-uninfected women.

Trop Med Int Health 2017 05 16;22(5):604-613. Epub 2017 Mar 16.

Division of Anatomical Pathology, Stellenbosch University, Cape Town, South Africa.

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http://dx.doi.org/10.1111/tmi.12858DOI Listing
May 2017

Second- and Third-line Antiretroviral Therapy for Children and Adolescents: A Scoping Review.

Pediatr Infect Dis J 2017 May;36(5):492-499

From the *Perinatal HIV Research Unit, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa; †FAMCRU, Children's' Infectious Diseases Clinical Research Unit, Department of Paediatrics and Child Health, Stellenbosch University, Cape Town, South Africa; ‡World Health Organization, HIV Department, Treatment and Care Unit, Geneva, Switzerland; and §Centre for Evidence-based Health Care, Department of Interdisciplinary Health, Faculty of Medicine and Health Sciences, Stellenbosch University, Stellenbosch, South Africa.

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http://dx.doi.org/10.1097/INF.0000000000001481DOI Listing
May 2017

Antiretroviral treatment in HIV-infected children who require a rifamycin-containing regimen for tuberculosis.

Expert Opin Pharmacother 2017 Apr 27;18(6):589-598. Epub 2017 Mar 27.

a Department of Paediatrics and Child Health, Faculty of Medicine and Health Sciences , Stellenbosch University and Tygerberg Hospital , Cape Town , South Africa.

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http://dx.doi.org/10.1080/14656566.2017.1309023DOI Listing
April 2017

Re: "It May Be Too Early to Try to Prove the Effect of Deworming on Tuberculin Reactivity".

Pediatr Infect Dis J 2017 02;36(2):241-242

Desmond Tutu TB Centre, Department of Paediatrics and Child Health, Faculty of Medicine and Health Sciences, Stellenbosch University, Cape Town, South Africa Section on Global and Immigration Health, Department of Pediatrics, Baylor College of Medicine, Houston, Texas Department of General Pediatrics, Neonatology and Pediatric Cardiology, University Children's Hospital, Duesseldorf, Germany The International Union Against Tuberculosis and Lung Disease, Paris, France Department of Pediatric Pneumology and Immunology, Charité-Universitätsmedizin, Berlin, Germany, Division of Global Health Equity, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts Department of Clinical Science, Faculty of Medicine and Dentistry, University of Bergen, Bergen, Norway, Department of Microbiology, Haukeland University Hospital, Bergen, Norway FAM-CRU, Department of Paediatrics and Child Health, Faculty of Medicine and Health Sciences, Stellenbosch University, Cape Town, South Africa Immunology Research Group, DST/NRF Centre of Excellence for Biomedical Tuberculosis Research, MRC Centre for TB Research, Division of Molecular Biology and Human Genetics, Faculty of Medicine and Health Sciences, Stellenbosch University, Cape Town, South Africa Desmond Tutu TB Centre Department of Paediatrics and Child Health Faculty of Medicine and Health Sciences Stellenbosch University Cape Town, South Africa.

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http://dx.doi.org/10.1097/INF.0000000000001408DOI Listing
February 2017

A Prospective Cohort Study of Common Childhood Infections in South African HIV-exposed Uninfected and HIV-unexposed Infants.

Pediatr Infect Dis J 2017 02;36(2):e38-e44

From the *Department of Paediatrics & Child Health, Faculty of Medicine and Health Sciences, Stellenbosch University, Stellenbosch, South Africa; †School of Population & Public Health, Faculty of Medicine, University of British Columbia, Vancouver, British Columbia, Canada; ‡Department of Pathology, Division of Medical Microbiology Immunology Unit, Stellenbosch University, Stellenbosch, South Africa; §Division of Paediatric Infectious Diseases, Department of Paediatrics & Child Health, Faculty of Medicine and Health Sciences, Stellenbosch University, Stellenbosch, South Africa; ¶Department of Pediatrics, Division of Pediatric Infectious Diseases, BC Children's Hospital and University of British Columbia, and ‖Faculty of Medicine, School of Population & Public Health, Faculty of Medicine, University of British Columbia, Vancouver, British Columbia, Canada.

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http://Insights.ovid.com/crossref?an=00006454-201702000-0001
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http://dx.doi.org/10.1097/INF.0000000000001391DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5242219PMC
February 2017

Assessment of terminal cleaning in pediatric isolation rooms: Options for low-resource settings.

Am J Infect Control 2016 12 22;44(12):1558-1564. Epub 2016 Aug 22.

Department of Paediatrics and Child Health, Division of Paediatric Infectious Diseases, Stellenbosch University, Cape Town, South Africa.

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http://dx.doi.org/10.1016/j.ajic.2016.05.026DOI Listing
December 2016

Optimizing Research Methods to Understand HIV-Exposed Uninfected Infant and Child Morbidity: Report of the Second HEU Infant and Child Workshop.

Front Immunol 2016 6;7:576. Epub 2016 Dec 6.

Faculty of Medicine and Health Sciences, Division of Paediatric Infectious Diseases and Family Clinical Research Unit (FAM-CRU), Department of Paediatrics and Child Health, Stellenbosch University , Stellenbosch , South Africa.

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http://dx.doi.org/10.3389/fimmu.2016.00576DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5138183PMC
December 2016

Healthcare-associated infections in children: knowledge, attitudes and practice of paediatric healthcare providers at Tygerberg Hospital, Cape Town.

Paediatr Int Child Health 2016 Aug;36(3):225-31

a Department of Paediatrics and Child Health, Division of Paediatric Infectious Diseases, Faculty of Medicine and Health Sciences , Stellenbosch University and Tygerberg Childrens' Hospital.

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http://dx.doi.org/10.1179/2046905515Y.0000000032DOI Listing
August 2016

Delayed BCG immunization does not alter antibody responses to EPI vaccines in HIV-exposed and -unexposed South African infants.

Vaccine 2016 07 4;34(32):3702-9. Epub 2016 Apr 4.

Division of Immunology, Institute of Infectious Disease and Molecular Medicine and Clinical Laboratory Sciences, University of Cape Town, South Africa; Seattle Children's Research Institute and Departments of Pediatrics and Global Health, University of Washington, Seattle, WA, USA.

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http://dx.doi.org/10.1016/j.vaccine.2016.03.081DOI Listing
July 2016

The Effect of Deworming on Tests of Tuberculosis Infection in Children With Recent Tuberculosis Exposure: A Randomized Controlled Trial.

Pediatr Infect Dis J 2016 06;35(6):622-7

From the *Faculty of Medicine and Health Sciences, Department of Paediatrics and Child Health, Desmond Tutu TB Centre, Stellenbosch University, Stellenbosch, South Africa; †Section on Global and Immigration Health, Department of Pediatrics, Baylor College of Medicine, Houston, Texas; ‡Department of General Pediatrics, Neonatology and Pediatric Cardiology, University Children's Hospital, Duesseldorf, Germany; §The International Union Against Tuberculosis and Lung Disease, Paris, France; ¶Department of Pediatric Pneumology and Immunology, Charité-Universitätsmedizin, Berlin, Germany; ‖Division of Global Health Equity, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts; **Faculty of Medicine and Dentistry, Department of Clinical Science, University of Bergen, Bergen, Norway; ††Department of Microbiology, Haukeland University Hospital, Bergen, Norway; ‡‡FAM-CRU, Faculty of Medicine and Health Sciences, Department of Paediatrics and Child Health, Stellenbosch University, Stellenbosch, South Africa; and §§Immunology Research Group, DST/NRF Centre of Excellence for Biomedical Tuberculosis Research and MRC Centre for TB Research, Faculty of Medicine and Health Sciences, Division of Molecular Biology and Human Genetics, Stellenbosch University, Stellenbosch, South Africa.

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http://dx.doi.org/10.1097/INF.0000000000001115DOI Listing
June 2016

HIV-associated CD4+/CD8+ depletion in infancy is associated with neurometabolic reductions in the basal ganglia at age 5 years despite early antiretroviral therapy.

AIDS 2016 06;30(9):1353-62

aMRC/UCT Medical Imaging Research Unit, Department of Human Biology, Faculty of Health Sciences, University of Cape Town bChildren's Infectious Diseases Clinical Research Unit, Department of Paediatrics & Child Health, Tygerberg Children's Hospital and Faculty of Medicine and Health Sciences, Stellenbosch University, Cape Town, South Africa cA.A. Martinos Centre for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Charlestown dDepartment of Radiology, Harvard Medical School, Boston, Massachusetts, USA eDepartment of Statistical Sciences, Faculty of Sciences, University of Cape Town, South Africa fOxford Centre for Clinical Magnetic Resonance Research (OCMR), Division of Cardiovascular Medicine, Radcliffe Department of Medicine, University of Oxford, Oxford, UK.

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http://dx.doi.org/10.1097/QAD.0000000000001082DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4864158PMC
June 2016

Feeding practices and nutritional status of HIV-exposed and HIV-unexposed infants in the Western Cape.

South Afr J HIV Med 2016 13;17(1):398. Epub 2016 May 13.

Department of Pathology, National Health Laboratory Service Immunology Unit (NHLS), Stellenbosch University, Tygerberg Campus, South Africa.

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http://dx.doi.org/10.4102/sajhivmed.v17i1.398DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5843154PMC
May 2016

Pattern of Infectious Morbidity in HIV-Exposed Uninfected Infants and Children.

Front Immunol 2016 6;7:164. Epub 2016 May 6.

Division of Pediatric Infectious Diseases, Department of Pediatrics, Vaccine Evaluation Center, BC Children's Hospital, University of British Columbia , Vancouver, BC , Canada.

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http://dx.doi.org/10.3389/fimmu.2016.00164DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4858536PMC
May 2016

High Prevalence of Dyslipidemia and Insulin Resistance in HIV-infected Prepubertal African Children on Antiretroviral Therapy.

Pediatr Infect Dis J 2016 Jan;35(1):e1-7

From the *Department of Paediatrics and Child Health, Children's Infectious Disease Clinical Research Unit, Stellenbosch University and Tygerberg Children's Hospital, Cape Town, South Africa; and †Department of Medicine, University of California San Diego, La Jolla, California.

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http://pdfs.journals.lww.com/pidj/2016/01000/High_Prevalence
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http://content.wkhealth.com/linkback/openurl?sid=WKPTLP:land
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http://dx.doi.org/10.1097/INF.0000000000000927DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4707556PMC
January 2016

Implementation and Operational Research: Implementation of the WHO 2011 Recommendations for Isoniazid Preventive Therapy (IPT) in Children Living With HIV/AIDS: A Ugandan Experience.

J Acquir Immune Defic Syndr 2016 Jan;71(1):e1-8

*Department of Mother and Child Health, University of Padova, Padova, Italy;†Nsambya Home Care of St. Raphael of St. Francis Hospital, Kampala, Uganda;‡Research Center of Montreal University Health Center (CRCHUM)-Global Health, Montreal, Québec, Canada;§Associazione Casa Accoglienza alla Vita Padre Angelo, Trento, Italy;‖Department of Paediatrics and Child Health, Tygerberg Children's Hospital and Stellenbosch University, Tygerberg, South Africa; and¶MRC Clinical Trials Unit at UCL, London, United Kingdom.

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http://dx.doi.org/10.1097/QAI.0000000000000806DOI Listing
January 2016

Hope of post-treatment control after perinatal infection?

Lancet HIV 2016 Jan 9;3(1):e6-8. Epub 2015 Dec 9.

Department of Paediatrics and Child Health and Family Clinical Research Unit, Faculty of Medicine and Health Sciences, Stellenbosch University, PO Box 241, Cape Town 8000, South Africa.

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http://dx.doi.org/10.1016/S2352-3018(15)00245-3DOI Listing
January 2016

Chest radiographic abnormalities in HIV-infected African children: a longitudinal study.

Thorax 2015 Sep 9;70(9):840-6. Epub 2015 Jun 9.

Department of Paediatrics and Child Health, Red Cross War Memorial Children's Hospital and MRC Unit on Child & Adolescent Health, University of Cape Town, Cape Town, South Africa.

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http://dx.doi.org/10.1136/thoraxjnl-2014-206105DOI Listing
September 2015

Utilization of paediatric isolation facilities in a TB-endemic setting.

Antimicrob Resist Infect Control 2015 21;4:36. Epub 2015 Sep 21.

Department of Medical Microbiology, Stellenbosch University and the National Health Laboratory Service (NHLS), Cape Town, South Africa.

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http://dx.doi.org/10.1186/s13756-015-0078-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4578346PMC
September 2015

Hepatitis B virus infection in HIV-exposed infants in the Western Cape, South Africa.

Vaccine 2015 Aug 9;33(36):4618-22. Epub 2015 Jul 9.

Division of Medical Virology, National Health Laboratory Service and Faculty of Medicine and Health Sciences, Stellenbosch University, Tygerberg, South Africa.

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http://dx.doi.org/10.1016/j.vaccine.2015.06.076DOI Listing
August 2015

Universal children's day--let's improve current interventions to reduce vertical transmission of HIV now.

J Int AIDS Soc 2014 20;17:19875. Epub 2014 Nov 20.

Department of Paediatrics and Child Health, Faculty of Medicine and Health Sciences, Stellenbosch University, Stellenbosch, South Africa.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4240851PMC
http://dx.doi.org/10.7448/IAS.17.1.19875DOI Listing
June 2015

Longitudinal study on Streptococcus pneumoniae, Haemophilus influenzae and Staphylococcus aureus nasopharyngeal colonization in HIV-infected and -uninfected infants vaccinated with pneumococcal conjugate vaccine.

Vaccine 2015 May 21;33(23):2662-9. Epub 2015 Apr 21.

Department of Science/National Research Foundation: Vaccine Preventable Diseases, University of the Witwatersrand, Faculty of Health Science, Johannesburg, South Africa; Medical Research Council: Respiratory and Meningeal Pathogens Research Unit, Johannesburg, South Africa.

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http://dx.doi.org/10.1016/j.vaccine.2015.04.024DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4436702PMC
May 2015

Optimizing the detection of recent tuberculosis infection in children in a high tuberculosis-HIV burden setting.

Am J Respir Crit Care Med 2015 Apr;191(7):820-30

1 Section on Retrovirology and Global Health, Department of Pediatrics, Baylor College of Medicine, Houston, Texas.

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http://dx.doi.org/10.1164/rccm.201406-1165OCDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4407483PMC
April 2015

Effect of reducing the paediatric stavudine dose by half: a physiologically-based pharmacokinetic model.

Int J Antimicrob Agents 2015 Apr 19;45(4):413-9. Epub 2015 Jan 19.

Children's Infectious Diseases Clinical Research Unit, Tygerberg Children's Hospital and Stellenbosch University, Cape Town, South Africa.

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http://dx.doi.org/10.1016/j.ijantimicag.2014.12.016DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4746231PMC
April 2015

Trends in paediatric bloodstream infections at a South African referral hospital.

BMC Pediatr 2015 Apr 2;15:33. Epub 2015 Apr 2.

Department of Medical Microbiology, Stellenbosch University and the National Health Laboratory Service (NHLS), Cape Town, South Africa.

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http://bmcpediatr.biomedcentral.com/articles/10.1186/s12887-
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http://dx.doi.org/10.1186/s12887-015-0354-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4396163PMC
April 2015

Maintenance of antiretroviral efficacy in children.

Lancet HIV 2015 Apr 17;2(4):e120-1. Epub 2015 Mar 17.

Children's Infectious Diseases Clinical Research Unit and Department of Paediatrics and Child Health, Faculty of Medicine and Health Sciences, Stellenbosch University, Stellenbosch, South Africa.

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http://dx.doi.org/10.1016/S2352-3018(15)00040-5DOI Listing
April 2015

Complicated and protracted cryptococcal disease in HIV-infected children.

Pediatr Infect Dis J 2015 Jan;34(1):62-5

From the *Department of Paediatrics and Child Health, Stellenbosch University and Tygerberg Children's Hospital; and †Children's Infectious Diseases Research Unit (KIDCRU), Stellenbosch University, Tygerberg, Cape Town, South Africa.

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http://dx.doi.org/10.1097/INF.0000000000000480DOI Listing
January 2015

Impact of earlier combination antiretroviral therapy on outcomes in children.

Curr Opin HIV AIDS 2015 Jan;10(1):12-7

Division of Paediatric Infectious Diseases, Department of Pediatrics and Child Health, Stellenbosch University and Tygerberg Children's Hospital, Tygerberg, Cape Town, South Africa.

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http://dx.doi.org/10.1097/COH.0000000000000117DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4429285PMC
January 2015

Next generation sequencing improves detection of drug resistance mutations in infants after PMTCT failure.

J Clin Virol 2015 Jan 20;62:48-53. Epub 2014 Nov 20.

Division of Medical Virology, Department of Pathology, Faculty of Medicine and Health Sciences, Stellenbosch University, Francie van Zilj Drive, Parow 7500, South Africa; National Health Laboratory Service, Tygerberg, Francie van Zijl Drive, Parow 7500, South Africa. Electronic address:

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http://dx.doi.org/10.1016/j.jcv.2014.11.014DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4279108PMC
January 2015

Nevirapine concentrations in preterm and low birth weight HIV-exposed infants: implications for dosing recommendations.

Pediatr Infect Dis J 2014 Dec;33(12):1231-3

From the *Division of Clinical Pharmacology, Department of Medicine, and †Department of Paediatrics, University of Cape Town, Cape Town; and ‡Department of Paediatrics and Child Health, Stellenbosch University, Stellenbosch, South Africa.

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http://dx.doi.org/10.1097/INF.0000000000000453DOI Listing
December 2014

Severe manifestations of extrapulmonary tuberculosis in HIV-infected children initiating antiretroviral therapy before 2 years of age.

Arch Dis Child 2014 Nov 17;99(11):998-1003. Epub 2014 Jun 17.

Department of Paediatrics and Child Health, Tygerberg Academic Hospital, Stellenbosch University, Cape Town, South Africa.

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http://dx.doi.org/10.1136/archdischild-2013-305509DOI Listing
November 2014

Infections in HIV-exposed uninfected children with focus on sub-Saharan Africa.

Pediatr Infect Dis J 2014 Oct;33(10):1085-6

From the Department of Pediatrics and Child Health, Children's Infectious Diseases Clinical Research Unit, Stellenbosch University and Tygerberg Hospital, Cape Town, South Africa.

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http://dx.doi.org/10.1097/INF.0000000000000489DOI Listing
October 2014

Early severe HIV disease precedes early antiretroviral therapy in infants: Are we too late?

J Int AIDS Soc 2014 11;17:18914. Epub 2014 Jun 11.

Children's Infectious Diseases Clinical Research Unit (KID-CRU), Stellenbosch University and Tygerberg Children's Hospital, Cape Town, South Africa.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4056161PMC
http://dx.doi.org/10.7448/IAS.17.1.18914DOI Listing
September 2014

Predictors of virologic and clinical response to nevirapine versus lopinavir/ritonavir-based antiretroviral therapy in young children with and without prior nevirapine exposure for the prevention of mother-to-child HIV transmission.

Pediatr Infect Dis J 2014 Aug;33(8):846-54

From the *Center for Biostatistics in AIDS Research, Harvard School of Public Health, Boston, MA; †University of Witwatersrand, Perinatal HIV Research Unit, Chris Hani Baragwanath Hospital, Johannesburg, South Africa; ‡Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, MD; §Department of Epidemiology, ICAP, Mailman School of Public Health and College of Physicians and Surgeons, Columbia University, New York, NY; ¶Department of Paediatrics and Child Health, University of Zimbabwe College of Health Sciences, Harare, Zimbabwe; ‖Makerere University-Johns Hopkins University Research Collaboration, Kampala, Uganda; **University of North Carolina Project, Lilongwe, Malawi; ††University Teaching Hospital, Lusaka, Zambia; ‡‡Division of Paediatrics and Infectious Diseases, Tygerberg Children's Hospital, Stellenbosch University, Tygerberg; §§University of the Witwatersrand Reproductive Health and HIV Institute, Faculty of Health Sciences, Johannesburg, South Africa; ¶¶Department of Pediatrics, BJ Medical College and Sassoon General Hospital, Pune, India; ‖‖Duke University-Kilimanjaro Christian Medical Center Collaboration, Moshi, Tanzania; ***Department of Paediatrics and Child Health, Nelson R Mandela School of Medicine, University of KwaZulu-Natal, Durban, South Africa; †††Frontier Science and Technology Research Foundation, Amherst, NY; ‡‡‡Social and Scientific Systems, Durham, NC; §§§Maternal and Pediatric Infectious Disease Branch, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Rockville, MD; ¶¶¶HJF-DAIDS, a Division of The Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc., Contractor to NIAID, NIH, DHHS, Bethesda, MD; and ‖‖‖Division of Infectious Diseases and International Health, Geisel School of Medicine at Dartmouth, One Medical Center Drive, Lebanon, NH.

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http://dx.doi.org/10.1097/INF.0000000000000337DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4166566PMC
August 2014

Spastic diplegia in children with HIV encephalopathy: first description of gait and physical status.

Dev Med Child Neurol 2014 Jul 3;56(7):686-94. Epub 2013 Nov 3.

Neurosurgery Division, Department of Surgery, Faculty of Health Sciences, University of Cape Town, Cape Town, South Africa; Physiotherapy Division, Department of Interdisciplinary Health Sciences, Faculty of Medicine and Health Sciences, Stellenbosch University, Tygerberg, South Africa.

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http://dx.doi.org/10.1111/dmcn.12319DOI Listing
July 2014

Altered innate immune development in HIV-exposed uninfected infants.

J Acquir Immune Defic Syndr 2014 Jul;66(3):245-255

Division of Infectious & Immunological Diseases, and Centre for Understanding and Preventing Infections in Children, Department of Pediatrics, University of British Columbia, Vancouver, V5Z 4H4, Canada.

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http://dx.doi.org/10.1097/QAI.0000000000000161DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4146715PMC
July 2014

The BCG replacement vaccine VPM1002: from drawing board to clinical trial.

Expert Rev Vaccines 2014 May 7;13(5):619-30. Epub 2014 Apr 7.

Department of Immunology, Max Planck Institute for Infection Biology, Berlin, Germany.

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http://dx.doi.org/10.1586/14760584.2014.905746DOI Listing
May 2014

Effect of HIV-1 exposure and antiretroviral treatment strategies in HIV-infected children on immunogenicity of vaccines during infancy.

AIDS 2014 Feb;28(4):531-41

aDepartment of Science and Technology/National Research Foundation: Vaccine Preventable Diseases; Johannesburg bMedical Research Council, Respiratory and Meningeal Pathogens Research Unit, Faculty Health Sciences; University of the Witwatersrand, Faculty of Health Sciences, Johannesburg; cPerinatal HIV Research Unit, University of the Witwatersrand, Faculty of Health Sciences dStellenbosch University, Children's Infectious Diseases Clinical Research Unit, Tygerberg eDivision of National Health Laboratory Service, National Institute for Communicable Diseases, Centre for Vaccines and Immunology, Sandringham, South Africa.

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http://dx.doi.org/10.1097/QAD.0000000000000127DOI Listing
February 2014

Effects of postnatal interventions for the reduction of vertical HIV transmission on infant growth and non-HIV infections: a systematic review.

J Int AIDS Soc 2013 Dec 20;16:18865. Epub 2013 Dec 20.

Department of Paediatrics and Child Health, Children's Infectious Disease Clinical Research Unit, Stellenbosch University, Tygerberg, South Africa.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3871831PMC
http://dx.doi.org/10.7448/IAS.16.1.18865DOI Listing
December 2013

Isoniazid preventive therapy in HIV-infected and -uninfected children (0 - 14 years).

S Afr Med J 2013 Sep 4;103(10):714-5. Epub 2013 Sep 4.

Department of Paediatrics and Child Health, Faculty of Medicine and Health Sciences, Stellenbosch University, South Africa.

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http://dx.doi.org/10.7196/samj.7189DOI Listing
September 2013