Mark Donowitz

Mark Donowitz

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Mark Donowitz

Mark Donowitz

Publications by authors named "Mark Donowitz"

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100Publications

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Enterohemorrhagic (EHEC)-Secreted Serine Protease EspP Stimulates Electrogenic Ion Transport in Human Colonoid Monolayers.

Toxins (Basel) 2018 Sep 1;10(9). Epub 2018 Sep 1.

Department of Medicine, Division of Gastroenterology & Hepatology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.

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September 2018

Cholera toxin inhibits SNX27-retromer-mediated delivery of cargo proteins to the plasma membrane.

J Cell Sci 2018 Aug 17;131(16). Epub 2018 Aug 17.

Departments of Medicine and Physiology, School of Medicine, Johns Hopkins University, Baltimore, MD 21205, USA

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August 2018

Identifying the localization and exploring a functional role for Gprc5c in the kidney.

FASEB J 2018 Apr 5;32(4):2046-2059. Epub 2018 Jan 5.

Department of Physiology, The Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.

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April 2018

Molecular Basis and Differentiation-Associated Alterations of Anion Secretion in Human Duodenal Enteroid Monolayers.

Cell Mol Gastroenterol Hepatol 2018 9;5(4):591-609. Epub 2018 Feb 9.

Department of Medicine, Division of Gastroenterology and Hepatology, Johns Hopkins University School of Medicine, Baltimore, Maryland.

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February 2018

Both NHERF3 and NHERF2 are necessary for multiple aspects of acute regulation of NHE3 by elevated Ca, cGMP, and lysophosphatidic acid.

Am J Physiol Gastrointest Liver Physiol 2018 01 7;314(1):G81-G90. Epub 2017 Sep 7.

Department of Medicine, the Johns Hopkins School of Medicine, Baltimore, Maryland.

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January 2018

Epithelial WNT Ligands Are Essential Drivers of Intestinal Stem Cell Activation.

Cell Rep 2018 Jan 28;22(4):1003-1015. Epub 2018 Jan 28.

Department of Molecular Virology and Microbiology, Baylor College of Medicine, Houston, TX 77030, USA; Section of Gastroenterology and Hepatology, Department of Medicine, Baylor College of Medicine, Houston, TX 77030, USA. Electronic address:

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January 2018

Gastrointestinal microphysiological systems.

Exp Biol Med (Maywood) 2017 10 23;242(16):1633-1642. Epub 2017 May 23.

1 Department of Molecular Virology and Microbiology, Baylor College of Medicine, Houston, TX 77030, USA.

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October 2017

Catching the Zebra: Clinical Pearls and Pitfalls for the Successful Diagnosis of Zollinger-Ellison Syndrome.

Dig Dis Sci 2017 09 3;62(9):2258-2265. Epub 2017 Aug 3.

Division of Gastroenterology and Hepatology, Department of Internal Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA.

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September 2017

A common NHE3 single-nucleotide polymorphism has normal function and sensitivity to regulatory ligands.

Am J Physiol Gastrointest Liver Physiol 2017 Aug 11;313(2):G129-G137. Epub 2017 May 11.

Department of Medicine, Division of Gastroenterology, Johns Hopkins University School of Medicine, Baltimore, Maryland;

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August 2017

Phosphorylation of NHE3-S regulates NHE3 activity through the formation of multiple signaling complexes.

Mol Biol Cell 2017 Jul 11;28(13):1754-1767. Epub 2017 May 11.

Department of Physiology and Department of Medicine, GI Division, Johns Hopkins University School of Medicine, Baltimore, MD 21205

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July 2017

PDZ domain-dependent regulation of NHE3 protein by both internal Class II and C-terminal Class I PDZ-binding motifs.

J Biol Chem 2017 05 10;292(20):8279-8290. Epub 2017 Mar 10.

From the Departments of Physiology and Medicine, Gastroenterology Division, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21205

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May 2017

Phenylquinoxalinone CFTR activator as potential prosecretory therapy for constipation.

Transl Res 2017 04 15;182:14-26.e4. Epub 2016 Oct 15.

Departments of Medicine and Physiology, University of California San Francisco, San Francisco, Calif. Electronic address:

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April 2017

The Zn-sensing receptor, ZnR/GPR39, upregulates colonocytic Cl absorption, via basolateral KCC1, and reduces fluid loss.

Biochim Biophys Acta Mol Basis Dis 2017 Apr 16;1863(4):947-960. Epub 2017 Jan 16.

Department of Physiology and Cell Biology, Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer Sheva, Israel. Electronic address:

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April 2017

A primary human macrophage-enteroid co-culture model to investigate mucosal gut physiology and host-pathogen interactions.

Sci Rep 2017 03 27;7:45270. Epub 2017 Mar 27.

Department of Medicine, Division of Gastroenterology and Hepatology, Johns Hopkins University School of Medicine, Baltimore, MD, USA.

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March 2017

The Contributions of Human Mini-Intestines to the Study of Intestinal Physiology and Pathophysiology.

Annu Rev Physiol 2017 02;79:291-312

Department of Medicine, Division of Gastroenterology, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205; email:

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February 2017

Human mini-guts: new insights into intestinal physiology and host-pathogen interactions.

Nat Rev Gastroenterol Hepatol 2016 Nov 28;13(11):633-642. Epub 2016 Sep 28.

Department of Medicine, Division of Gastroenterology, The Johns Hopkins University School of Medicine, 720 Rutland Avenue, Baltimore, Maryland 21205, USA.

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November 2016

Practical Advice From a Basic and Translational Researcher at a Major Medical School.

Authors:
Mark Donowitz

Cell Mol Gastroenterol Hepatol 2016 Nov 6;2(6):707-709. Epub 2016 Sep 6.

Gastrointestinal Division, Departments of Medicine and Physiology, Johns Hopkins University School of Medicine, Baltimore, Maryland.

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November 2016

Human Enteroids as a Model of Upper Small Intestinal Ion Transport Physiology and Pathophysiology.

Gastroenterology 2016 Mar 8;150(3):638-649.e8. Epub 2015 Dec 8.

Department of Medicine, Division of Gastroenterology, Johns Hopkins University School of Medicine, Baltimore, Maryland. Electronic address:

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March 2016

Human Enteroids/Colonoids and Intestinal Organoids Functionally Recapitulate Normal Intestinal Physiology and Pathophysiology.

J Biol Chem 2016 Feb 16;291(8):3759-66. Epub 2015 Dec 16.

From the Division of Gastroenterology and Hepatology, Department of Medicine, and Department of Physiology, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205,

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February 2016

Enterohemorrhagic reduce mucus and intermicrovillar bridges in human stem cell-derived colonoids.

Cell Mol Gastroenterol Hepatol 2016 Jan;2(1):48-62.e3

Department of Medicine, Division of Gastroenterology and Hepatology, Johns Hopkins University School of Medicine, Baltimore, MD.

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January 2016

Secretory diarrhoea: mechanisms and emerging therapies.

Nat Rev Gastroenterol Hepatol 2015 Aug 30;12(8):446-57. Epub 2015 Jun 30.

Departments of Medicine and Physiology, 1246 Health Sciences East Tower, University of California, 500 Parnassus Avenue, San Francisco, CA 94143, USA.

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August 2015

The NHERF2 sequence adjacent and upstream of the ERM-binding domain affects NHERF2-ezrin binding and dexamethasone stimulated NHE3 activity.

Biochem J 2015 Aug 16;470(1):77-90. Epub 2015 Jun 16.

Departments of Medicine, Division of Gastroenterology, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, U.S.A. Department of Physiology, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, U.S.A.

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August 2015

Sorting nexin 27 regulates basal and stimulated brush border trafficking of NHE3.

Mol Biol Cell 2015 Jun 7;26(11):2030-43. Epub 2015 Apr 7.

Gastroenterology Division, Departments of Physiology and Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21205

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June 2015

Nonsynonymous single nucleotide polymorphisms of NHE3 differentially decrease NHE3 transporter activity.

Am J Physiol Cell Physiol 2015 May 25;308(9):C758-66. Epub 2015 Feb 25.

Departments of Physiology and Medicine, Division of Gastroenterology, Johns Hopkins University School of Medicine, Baltimore, Maryland; and

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May 2015

Fractionation of subcellular membrane vesicles of epithelial and non-epithelial cells by OptiPrep™ density gradient ultracentrifugation.

Methods Mol Biol 2014 ;1174:85-99

GI Division, Department of Medicine, Johns Hopkins University School of Medicine, 918 Ross Research Bldg, 720 Rutland Ave, 21205, Baltimore, MD, USA,

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January 2015

Human enteroids as an ex-vivo model of host-pathogen interactions in the gastrointestinal tract.

Exp Biol Med (Maywood) 2014 Sep 9;239(9):1124-34. Epub 2014 Apr 9.

Department of Medicine, Division of Gastroenterology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA

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September 2014

Myosin VI mediates the movement of NHE3 down the microvillus in intestinal epithelial cells.

J Cell Sci 2014 Aug 13;127(Pt 16):3535-45. Epub 2014 Jun 13.

Department of Medicine, Division of Gastroenterology and Hepatology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA Departments of Medicine and Physiology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA

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August 2014

Lysophosphatidic acid stimulation of NHE3 exocytosis in polarized epithelial cells occurs with release from NHERF2 via ERK-PLC-PKCδ signaling.

Am J Physiol Cell Physiol 2014 Jul 23;307(1):C55-65. Epub 2014 Apr 23.

Departments of Physiology and Medicine, Gastrointestinal Division, The Johns Hopkins University School of Medicine, Baltimore, Maryland; and

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July 2014

NHERF2/NHERF3 protein heterodimerization and macrocomplex formation are required for the inhibition of NHE3 activity by carbachol.

J Biol Chem 2014 Jul 27;289(29):20039-53. Epub 2014 May 27.

From the Department of Medicine, Division of Gastroenterology and Department of Physiology, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21205

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July 2014

Farnesoid X receptor agonists attenuate colonic epithelial secretory function and prevent experimental diarrhoea in vivo.

Gut 2014 May 5;63(5):808-17. Epub 2013 Aug 5.

Department of Molecular Medicine, RCSI Education and Research Centre, Beaumont Hospital, , Dublin, Ireland.

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May 2014

Microfluidics platform for measurement of volume changes in immobilized intestinal enteroids.

Biomicrofluidics 2014 Mar 1;8(2):024106. Epub 2014 Apr 1.

Departments of Medicine and Physiology, University of California, San Francisco, California 94143, USA.

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March 2014

Discovery and development of antisecretory drugs for treating diarrheal diseases.

Clin Gastroenterol Hepatol 2014 Feb 4;12(2):204-9. Epub 2013 Dec 4.

Departments of Medicine and Physiology, University of California, San Francisco, San Francisco, California. Electronic address:

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February 2014

AKT and GSK-3 are necessary for direct ezrin binding to NHE3 as part of a C-terminal stimulatory complex: role of a novel Ser-rich NHE3 C-terminal motif in NHE3 activity and trafficking.

J Biol Chem 2014 Feb 7;289(9):5449-61. Epub 2014 Jan 7.

From the Departments of Physiology and Medicine, Gastroenterology Division, Johns, Hopkins University School of Medicine, Baltimore, Maryland 21205 and.

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February 2014

Translating molecular physiology of intestinal transport into pharmacologic treatment of diarrhea: stimulation of Na+ absorption.

Clin Gastroenterol Hepatol 2014 Jan 31;12(1):27-31. Epub 2013 Oct 31.

Departments of Physiology and Medicine, Gastroenterology Division, Johns Hopkins University School of Medicine, Baltimore, Maryland. Electronic address:

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January 2014

SLC9/NHE gene family, a plasma membrane and organellar family of Na⁺/H⁺ exchangers.

Mol Aspects Med 2013 Apr-Jun;34(2-3):236-51

Departments of Medicine and Physiology, Johns Hopkins University School of Medicine, Baltimore, MD, United States.

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September 2013

Insulin-like growth factor 1 (IGF-1) enhances the protein expression of CFTR.

PLoS One 2013 28;8(3):e59992. Epub 2013 Mar 28.

Department of Physiology, Johns Hopkins University, School of Medicine, Baltimore, MD, USA.

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September 2013

PLC-γ directly binds activated c-Src, which is necessary for carbachol-mediated inhibition of NHE3 activity in Caco-2/BBe cells.

Am J Physiol Cell Physiol 2013 Aug 22;305(3):C266-75. Epub 2013 May 22.

Department of Medicine/Gastroenterology and Hepatology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.

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August 2013

NHERF2 protein mobility rate is determined by a unique C-terminal domain that is also necessary for its regulation of NHE3 protein in OK cells.

J Biol Chem 2013 Jun 23;288(23):16960-74. Epub 2013 Apr 23.

Department of Medicine, Division of Gastroenterology, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA.

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June 2013

Calmodulin kinase II constitutively binds, phosphorylates, and inhibits brush border Na+/H+ exchanger 3 (NHE3) by a NHERF2 protein-dependent process.

J Biol Chem 2012 Apr 27;287(16):13442-56. Epub 2012 Feb 27.

Division of Gastroenterology, Department of Medicine, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA.

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April 2012

Translational approaches for pharmacotherapy development for acute diarrhea.

Gastroenterology 2012 Mar 20;142(3):e1-9. Epub 2012 Jan 20.

Department of Medicine and Physiology, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA.

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March 2012

Elevated calcium acutely regulates dynamic interactions of NHERF2 and NHE3 proteins in opossum kidney (OK) cell microvilli.

J Biol Chem 2011 Oct 28;286(40):34486-96. Epub 2011 Jul 28.

Department of Medicine, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA.

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October 2011

NHERF2 is necessary for basal activity, second messenger inhibition, and LPA stimulation of NHE3 in mouse distal ileum.

Am J Physiol Cell Physiol 2011 Jul 23;301(1):C126-36. Epub 2011 Mar 23.

Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland 21287, USA.

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July 2011

Chloride channel (Clc)-5 is necessary for exocytic trafficking of Na+/H+ exchanger 3 (NHE3).

J Biol Chem 2011 Jul 11;286(26):22833-45. Epub 2011 May 11.

Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA.

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July 2011

NHERF1 and NHERF2 are necessary for multiple but usually separate aspects of basal and acute regulation of NHE3 activity.

Am J Physiol Cell Physiol 2011 Apr 29;300(4):C771-82. Epub 2010 Dec 29.

Gastroenterology and Hepatology Division, Department of Medicine, Johns Hopkins Univ. School of Medicine, Baltimore, MD 21205-2195, USA.

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April 2011

Genome-wide analysis reveals the vacuolar pH-stat of Saccharomyces cerevisiae.

PLoS One 2011 Mar 14;6(3):e17619. Epub 2011 Mar 14.

Department of Physiology, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America.

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March 2011

The spatial organization of proton and lactate transport in a rat brain tumor.

PLoS One 2011 Feb 24;6(2):e17416. Epub 2011 Feb 24.

Unit 836, Institut National de la Santé et de la Recherche Médicale, La Tronche, Isère, France.

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February 2011

NHE3 activity is dependent on direct phosphoinositide binding at the N terminus of its intracellular cytosolic region.

J Biol Chem 2010 Nov 24;285(45):34566-78. Epub 2010 Aug 24.

Department of Physiology and Medicine, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA.

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November 2010

NHE3 mobility in brush borders increases upon NHERF2-dependent stimulation by lyophosphatidic acid.

J Cell Sci 2010 Jul 22;123(Pt 14):2434-43. Epub 2010 Jun 22.

Departments of Physiology and Medicine, Gastroenterology Division, Johns Hopkins University School of Medicine, 720 Rutland Avenue, Baltimore, MD 212052, USA.

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July 2010

Mutations in TTC37 cause trichohepatoenteric syndrome (phenotypic diarrhea of infancy).

Gastroenterology 2010 Jun 20;138(7):2388-98, 2398.e1-2. Epub 2010 Feb 20.

Department of Medical and Molecular Genetics, School of Clinical and Experimental Medicine, University of Birmingham College of Medical and Dental School, Institute of Biomedical Research, Edgbaston, Birmingham, UK.

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June 2010

Refractory lymphocytic enterocolitis and tumor necrosis factor antagonist therapy.

Clin Gastroenterol Hepatol 2010 Apr 28;8(4):391-4. Epub 2009 Dec 28.

Department of Medicine, The Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.

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April 2010

Lysophosphatidic acid stimulates the intestinal brush border Na(+)/H(+) exchanger 3 and fluid absorption via LPA(5) and NHERF2.

Gastroenterology 2010 Feb 1;138(2):649-58. Epub 2009 Oct 1.

Division of Digestive Diseases, Department of Medicine, Emory University School of Medicine, Atlanta, Georgia 30322, USA.

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February 2010

PTH transiently increases the percent mobile fraction of Npt2a in OK cells as determined by FRAP.

Am J Physiol Renal Physiol 2009 Dec 30;297(6):F1560-5. Epub 2009 Sep 30.

Dept. of Medicine, Div. of Nephrology, Univ. of Maryland School of Medicine, Baltimore, MD 21202, USA.

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December 2009

NHERF3 (PDZK1) contributes to basal and calcium inhibition of NHE3 activity in Caco-2BBe cells.

J Biol Chem 2009 Aug 17;284(35):23708-18. Epub 2009 Jun 17.

Department of Medicine, Hopkins Center for Epithelial Disorders, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205-2195, USA.

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August 2009

Phospholipase C-gamma binds directly to the Na+/H+ exchanger 3 and is required for calcium regulation of exchange activity.

J Biol Chem 2009 Jul 27;284(29):19437-44. Epub 2009 May 27.

Division of Gastroenterology and Hepatology, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA.

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July 2009

NHE3 regulatory complexes.

J Exp Biol 2009 Jun;212(Pt 11):1638-46

Johns Hopkins University School of Medicine, 720 Rutland Avenue Baltimore, MD 21205, USA.

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June 2009

Regulation of intestinal electroneutral sodium absorption and the brush border Na+/H+ exchanger by intracellular calcium.

Ann N Y Acad Sci 2009 May;1165:240-8

Department of Medicine, Division of Gastroenterology, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA.

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May 2009

Differential roles of NHERF1, NHERF2, and PDZK1 in regulating CFTR-mediated intestinal anion secretion in mice.

J Clin Invest 2009 Mar 16;119(3):540-50. Epub 2009 Feb 16.

Department of Gastroenterology, Hepatology, and Endocrinology, Carl-Neuberg-Strasse 1, Hannover Medical School, Hannover, Germany.

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March 2009

Elevated intracellular calcium stimulates NHE3 activity by an IKEPP (NHERF4) dependent mechanism.

Cell Physiol Biochem 2008 9;22(5-6):693-704. Epub 2008 Dec 9.

Department of Medicine and Physiology, Hopkins Center for Epithelial Disorders, Johns Hopkins University School of Medicine, Baltimore, MD 21205-2195, USA.

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February 2009

Macropinocytosis in Shiga toxin 1 uptake by human intestinal epithelial cells and transcellular transcytosis.

Am J Physiol Gastrointest Liver Physiol 2009 Jan 30;296(1):G78-92. Epub 2008 Oct 30.

Dept. of Medicine, Division of Gastroenterology, 918 Ross Research Bldg., 720 Rutland Ave., Johns Hopkins School of Medicine, Baltimore, MD 21205, USA.

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January 2009

Casein kinase 2 binds to the C terminus of Na+/H+ exchanger 3 (NHE3) and stimulates NHE3 basal activity by phosphorylating a separate site in NHE3.

Mol Biol Cell 2008 Sep 9;19(9):3859-70. Epub 2008 Jul 9.

Division of Gastroenterology and Hepatology, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.

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September 2008

The epithelial brush border Na+/H+ exchanger NHE3 associates with the actin cytoskeleton by binding to ezrin directly and via PDZ domain-containing Na+/H+ exchanger regulatory factor (NHERF) proteins.

Clin Exp Pharmacol Physiol 2008 Aug 21;35(8):863-71. Epub 2008 Apr 21.

Department of Medicine, GI Division, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA.

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August 2008

Latrunculin B facilitates Shiga toxin 1 transcellular transcytosis across T84 intestinal epithelial cells.

Biochim Biophys Acta 2008 Jun 20;1782(6):370-7. Epub 2008 Feb 20.

Department of Medicine, Division of Gastroenterology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.

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June 2008

Fractionation of subcellular membrane vesicles of epithelial and nonepithelial cells by OptiPrep density gradient ultracentrifugation.

Methods Mol Biol 2008 ;440:97-110

GI Division, Department of Medicine, The Johns Hopkins University School of Medicine, Baltimore, MD, USA.

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May 2008

Urine electrolyte, mineral, and protein excretion in NHERF-2 and NHERF-1 null mice.

Am J Physiol Renal Physiol 2008 Apr 6;294(4):F1001-7. Epub 2008 Feb 6.

Univ. of Maryland School of Medicine, 22 S. Greene St., N3W143, Baltimore, MD 21201, USA.

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April 2008

Presidential address.

Authors:
Mark Donowitz

Gastroenterology 2007 Dec;133(6):e5-7

Johns HopkinsSchool of Medicine, 925 Ross Research Building, 720 Rutland Avenue,Baltimore, Maryland 21205, USA.

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December 2007

Regulatory binding partners and complexes of NHE3.

Physiol Rev 2007 Jul;87(3):825-72

Department of Medicine, GI Division, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA.

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July 2007

The attrition of young physician-scientists: problems and potential solutions.

Gastroenterology 2007 Feb;132(2):477-80

Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205-2195, USA.

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February 2007

The NHE3 juxtamembrane cytoplasmic domain directly binds ezrin: dual role in NHE3 trafficking and mobility in the brush border.

Mol Biol Cell 2006 Jun 15;17(6):2661-73. Epub 2006 Mar 15.

Department of Physiology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.

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June 2006

Na+/H+ exchanger NHE3 activity and trafficking are lipid Raft-dependent.

J Biol Chem 2006 Jun 27;281(26):17845-55. Epub 2006 Apr 27.

Departments of Physiology and Medicine, Division of Gastroenterology, The Johns Hopkins University School of Medicine, 720 Rutland Avenue, Baltimore, MD 21205, USA.

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June 2006

Does the proteome encode organellar pH?

FEBS Lett 2006 Feb 18;580(3):717-9. Epub 2006 Jan 18.

Department of Physiology, The Johns Hopkins University School of Medicine, 725 N. Wolfe Street, Baltimore, MD 21205, USA.

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February 2006

The glycosphingolipid globotriaosylceramide in the metastatic transformation of colon cancer.

Proc Natl Acad Sci U S A 2005 Dec 19;102(52):19087-92. Epub 2005 Dec 19.

Division of Gastroenterology, Department of Medicine, and Department of Surgery, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.

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December 2005

ClC-5: role in endocytosis in the proximal tubule.

Am J Physiol Renal Physiol 2005 Oct 7;289(4):F850-62. Epub 2005 Jun 7.

Dept. of Physiology, WBSB Rm. 208, The Johns Hopkins Univ. School of Medicine, 725 N. Wolfe St., Baltimore, MD 21205, USA.

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October 2005

NHERF family and NHE3 regulation.

J Physiol 2005 Aug 19;567(Pt 1):3-11. Epub 2005 May 19.

John Hopkins University School of Medicine, Departments of Medicine & Physiology, Baltimore, MD 21205, USA.

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August 2005

Molecular physiology of intestinal Na+/H+ exchange.

Annu Rev Physiol 2005 ;67:411-43

Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205-2195, USA.

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May 2005

Evolutionary origins of eukaryotic sodium/proton exchangers.

Am J Physiol Cell Physiol 2005 Feb;288(2):C223-39

Department of Medicine, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA.

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February 2005

NHERF2 increases platelet-derived growth factor-induced proliferation through PI-3-kinase/Akt-, ERK-, and Src family kinase-dependent pathway.

Cell Signal 2004 Jul;16(7):791-800

Department of Physiology, College of Medicine, Pusan National University, 1Ga, Ami-Dong, Suh-Gu, Pusan 602-739, South Korea.

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July 2004

The lateral mobility of NHE3 on the apical membrane of renal epithelial OK cells is limited by the PDZ domain proteins NHERF1/2, but is dependent on an intact actin cytoskeleton as determined by FRAP.

J Cell Sci 2004 Jul;117(Pt 15):3353-65

Department of Physiology, Gastroenterology Division, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.

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July 2004

Lysophosphatidic acid induces exocytic trafficking of Na(+)/H(+) exchanger 3 by E3KARP-dependent activation of phospholipase C.

Biochim Biophys Acta 2004 Jul;1683(1-3):59-68

Department of Physiology and Medicine, Gastrointestinal Division, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.

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July 2004

Carbachol regulation of rabbit ileal brush border Na+-H+ exchanger 3 (NHE3) occurs through changes in NHE3 trafficking and complex formation and is Src dependent.

J Physiol 2004 May 20;556(Pt 3):791-804. Epub 2004 Feb 20.

Department of Medicine, GI Division, John Hopkins University School of Medicine, Baltimore, MD 21205-2195, USA .

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May 2004