Mark D Minden

Mark D Minden

UNVERIFIED PROFILE

Are you Mark D Minden?   Register this Author

Register author
Mark D Minden

Mark D Minden

Publications by authors named "Mark D Minden"

Are you Mark D Minden?   Register this Author

100Publications

3886Reads

22Profile Views

Therapeutic Targeting of RNA Splicing Catalysis through Inhibition of Protein Arginine Methylation.

Cancer Cell 2019 Aug;36(2):194-209.e9

Institute of Molecular and Cell Biology, Agency for Science, Technology and Research (A(∗)STAR), Singapore 138673, Singapore; Department of Biochemistry, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 119077, Singapore; Department of Oncological Sciences and Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA; Department of Pharmacological Sciences and Mount Sinai Center for Therapeutics Discovery, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.ccell.2019.07.003DOI Listing
August 2019

Anti-leukemia effect of vitamin K3 is mediated through mitochondrial complexes I and II.

Leuk Lymphoma 2019 Jun 4:1-4. Epub 2019 Jun 4.

a Department of Food Science , University of Guelph , Guelph , Canada.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1080/10428194.2019.1620940DOI Listing
June 2019

Mitochondrial ClpP-Mediated Proteolysis Induces Selective Cancer Cell Lethality.

Cancer Cell 2019 May 2;35(5):721-737.e9. Epub 2019 May 2.

The University of Texas MD Anderson Cancer Center, Molecular Hematology and Therapy, Department of Leukemia, Houston, TX 77030, USA; The University of Texas MD Anderson Cancer Center; Department of Leukemia, Houston, TX 77030, USA. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.ccell.2019.03.014DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6620028PMC
May 2019

Characterization of inv(3) cell line OCI-AML-20 with stroma-dependent CD34 expression.

Exp Hematol 2019 01 22;69:27-36. Epub 2018 Oct 22.

Princess Margaret Cancer Centre, Toronto, Ontario, Canada; Department of Medical Biophysics, University of Toronto, Ontario, Canada. Electronic address:

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S0301472X183086
Publisher Site
http://dx.doi.org/10.1016/j.exphem.2018.10.006DOI Listing
January 2019

Octadecyloxyethyl Adefovir Exhibits Potent in vitro and in vivo Cytotoxic Activity and Has Synergistic Effects with Ara-C in Acute Myeloid Leukemia.

Chemotherapy 2018 29;63(4):225-237. Epub 2018 Oct 29.

Princess Margaret Hospital, Ontario Cancer Institute, Toronto, Ontario,

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1159/000491705DOI Listing
December 2018

Acute promyelocytic leukemia in the intensive care unit: A retrospective analysis.

Leuk Res 2018 10 31;73:41-43. Epub 2018 Aug 31.

Interdepartmental Division of Critical Care Medicine, Department of Medicine, Mount Sinai Hospital/University Health Network, University of Toronto, Ontario, Canada.

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S01452126183018
Publisher Site
http://dx.doi.org/10.1016/j.leukres.2018.08.004DOI Listing
October 2018

Prediction of acute myeloid leukaemia risk in healthy individuals.

Nature 2018 07 9;559(7714):400-404. Epub 2018 Jul 9.

Princess Margaret Cancer Centre, University Health Network (UHN), Toronto, Ontario, Canada.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/s41586-018-0317-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6485381PMC
July 2018

Leukemic stem cell signatures identify novel therapeutics targeting acute myeloid leukemia.

Blood Cancer J 2018 06 6;8(6):52. Epub 2018 Jun 6.

Department of Pediatrics, McGill University, Montreal, QC, Canada.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/s41408-018-0087-2DOI Listing
June 2018

Stability of sodium bicarbonate injection 8.4% in syringes over a six-week period in refrigerated temperature.

J Oncol Pharm Pract 2018 Apr 20;24(3):198-200. Epub 2017 Feb 20.

6 Department of Medical Oncology and Hematology, Princess Margaret Cancer Centre, University Health Network, Toronto, Canada.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1177/1078155217694493DOI Listing
April 2018

Targeting chemotherapy-resistant leukemia by combining DNT cellular therapy with conventional chemotherapy.

J Exp Clin Cancer Res 2018 Apr 24;37(1):88. Epub 2018 Apr 24.

Toronto General Hospital Research Institute, University Health Network, Toronto, Ontario, Canada.

View Article

Download full-text PDF

Source
https://jeccr.biomedcentral.com/articles/10.1186/s13046-018-
Publisher Site
http://dx.doi.org/10.1186/s13046-018-0756-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5916833PMC
April 2018

A novel chimeric antigen receptor containing a JAK-STAT signaling domain mediates superior antitumor effects.

Nat Med 2018 03 5;24(3):352-359. Epub 2018 Feb 5.

Tumor Immunotherapy Program, Campbell Family Institute for Breast Cancer Research, Campbell Family Cancer Research Institute, Princess Margaret Cancer Centre, University Health Network, Toronto, Ontario, Canada.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/nm.4478DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5839992PMC
March 2018

Predictive value of molecular remissions postconsolidation chemotherapy in patients with Core Binding Factor Acute Myeloid Leukemia (CBF-AML) - a single center analysis.

Hematol Oncol 2017 Dec 6;35(4):810-813. Epub 2016 Sep 6.

Leukemia Program, Division of Medical Oncology and Hematology, Princess Margaret Cancer Centre, University Health Network, Toronto, Ontario, Canada.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/hon.2341DOI Listing
December 2017

Outcomes and Predictors of Mortality for Patients with Acute Leukemia Admitted to the Intensive Care Unit.

Can Respir J 2016 30;2016:3027656. Epub 2016 Jun 30.

Department of Medicine & Interdepartmental Division of Critical Care, Mount Sinai Hospital, Toronto, ON, Canada M5G 1X5; Faculty of Medicine, University of Toronto, Toronto, ON, Canada M5S 1A8.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1155/2016/3027656DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4944052PMC
July 2017

HLA-DP constitutively presents endogenous peptides generated by the class I antigen processing pathway.

Nat Commun 2017 05 10;8:15244. Epub 2017 May 10.

Tumor Immunotherapy Program, Campbell Family Institute for Breast Cancer Research, Campbell Family Cancer Research Institute, Princess Margaret Cancer Centre, University Health Network, Toronto, Ontario, Canada M5G 2M9.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/ncomms15244DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5436232PMC
May 2017

The mitochondria target drug avocatin B synergizes with induction chemotherapeutics to induce leukemia cell death.

Leuk Lymphoma 2017 04 25;58(4):986-988. Epub 2016 Aug 25.

a School of Pharmacy, University of Waterloo , Waterloo , Ontario , Canada.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1080/10428194.2016.1218005DOI Listing
April 2017

High Frequency and Poor Outcome of Philadelphia Chromosome-Like Acute Lymphoblastic Leukemia in Adults.

J Clin Oncol 2017 Feb 21;35(4):394-401. Epub 2016 Nov 21.

Kathryn G. Roberts, Zhaohui Gu, Debbie Payne-Turner, Kelly McCastlain, Deqing Pei, Ilaria Iacobucci, Marcus Valentine, Stanley B. Pounds, Lei Shi, Yongjin Li, Jinghui Zhang, Cheng Cheng, and Charles G. Mullighan, St Jude Children's Research Hospital, Memphis, TN; Richard C. Harvey, I-Ming Chen, and Cheryl L. Willman, University of New Mexico Cancer Center, Albuquerque, NM; Alessandro Rambaldi, Manuela Tosi, and Orietta Spinelli, Ospedale Papa Giovanni XXIII, Bergamo, Italy; Jerald P. Radich, Fred Hutchinson Cancer Research Center, Seattle, WA; Mark D. Minden, Princess Margaret Cancer Centre, University Health Network, Toronto, Ontario, Canada; Jacob M. Rowe, Shaare Zedek Medical Center, Jerusalem, Israel; Selina Luger, Abramson Cancer Center, University of Pennsylvania, Philadelphia, PA; Mark R. Litzow, Mayo Clinic, Rochester, MN; Martin S. Tallman, Memorial Sloan Kettering Cancer Center, Weill Cornell Medical College, New York; Peter H. Wiernik, Cancer Research Foundation of New York; Elisabeth Paietta, Montefiore Medical Center, Albert Einstein College of Medicine, Bronx, NY; Ravi Bhatia, The University of Alabama at Birmingham, Birmingham, AL; Ibrahim Aldoss and Guido Marcucci, City of Hope, Duarte, CA; Jessica Kohlschmidt, Krzysztof Mrózek, and Clara D. Bloomfield, Comprehensive Cancer Center, The Ohio State University, Columbus, OH; Wendy Stock, University of Chicago Medical Center, Chicago, IL; and Stephen Kornblau, Hagop M. Kantarjian, and Marina Konopleva, The University of Texas MD Anderson Cancer Center, Houston, TX.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1200/JCO.2016.69.0073DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5455698PMC
February 2017

Preclinical validation: LV/IL-12 transduction of patient leukemia cells for immunotherapy of AML.

Mol Ther Methods Clin Dev 2016 7;3:16074. Epub 2016 Dec 7.

University Health Network, Toronto, Ontario, Canada; Department of Medical Biophysics, University of Toronto, Toronto, Ontario, Canada; Institute of Medical Science, University of Toronto, Toronto, Ontario, Canada.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/mtm.2016.74DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5142463PMC
December 2016

Phosphorylated STAT5 regulates p53 expression via BRCA1/BARD1-NPM1 and MDM2.

Cell Death Dis 2016 12 22;7(12):e2560. Epub 2016 Dec 22.

Laboratory of Medical and Molecular Oncology (LMMO), Department of Medical Oncology, Vrije Universiteit Brussel, Brussels, Belgium.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/cddis.2016.430DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5260985PMC
December 2016

Investigating the synergistic mechanism between ibrutinib and daunorubicin in acute myeloid leukemia cells.

Leuk Lymphoma 2016 10 17;57(10):2432-6. Epub 2016 Feb 17.

a Princess Margaret Cancer Centre, Ontario Cancer Institute , University Health Network , Toronto , ON , Canada ;

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3109/10428194.2016.1138292DOI Listing
October 2016

A phase I trial of the aurora kinase inhibitor, ENMD-2076, in patients with relapsed or refractory acute myeloid leukemia or chronic myelomonocytic leukemia.

Invest New Drugs 2016 10 12;34(5):614-24. Epub 2016 Jul 12.

Division of Medical Oncology and Hematology, Princess Margaret Cancer Centre, 610 University Avenue, Toronto, ON, M5G 2M9, Canada.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s10637-016-0375-2DOI Listing
October 2016

CD33, not early precursor T-cell phenotype, is associated with adverse outcome in adult T-cell acute lymphoblastic leukaemia.

Br J Haematol 2016 Mar 30;172(5):823-5. Epub 2015 Jun 30.

Department of Laboratory Haematology, University Health Network, Toronto, ON, Canada.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/bjh.13545DOI Listing
March 2016

An Integrated Analysis of Heterogeneous Drug Responses in Acute Myeloid Leukemia That Enables the Discovery of Predictive Biomarkers.

Cancer Res 2016 Mar 1;76(5):1214-24. Epub 2016 Feb 1.

Princess Margaret Cancer Centre, University Health Network, Toronto, Ontario, Canada. Department of Medicine, University of Toronto, Toronto, Ontario, Canada. Division of Medical Oncology and Hematology, University Health Network, Toronto, Ontario, Canada.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1158/0008-5472.CAN-15-2743DOI Listing
March 2016

Reversion to an embryonic alternative splicing program enhances leukemia stem cell self-renewal.

Proc Natl Acad Sci U S A 2015 Dec 30;112(50):15444-9. Epub 2015 Nov 30.

Division of Regenerative Medicine, Department of Medicine, Moores Cancer Center, University of California, San Diego, La Jolla, CA 92093-0820;

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1073/pnas.1506943112DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4687548PMC
December 2015

Carnitine transporter CT2 (SLC22A16) is over-expressed in acute myeloid leukemia (AML) and target knockdown reduces growth and viability of AML cells.

Apoptosis 2015 Aug;20(8):1099-108

Princess Margaret Cancer Centre, Ontario Cancer Institute, 610 University Ave, Toronto, ON, M5G 2M9, Canada.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s10495-015-1137-xDOI Listing
August 2015

Mitochondrial DNA damage by bleomycin induces AML cell death.

Apoptosis 2015 Jun;20(6):811-20

Princess Margaret Cancer Centre, Ontario Cancer Institute, University Health Network, Room 7-116, 610 University Ave, Toronto, ON, M5G 2M9, Canada.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s10495-015-1119-zDOI Listing
June 2015

Mode of action and pharmacogenomic biomarkers for exceptional responders to didemnin B.

Nat Chem Biol 2015 Jun 13;11(6):401-8. Epub 2015 Apr 13.

Department of Cell Biology, University of Texas Southwestern Medical Center, Dallas, Texas, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/nchembio.1797DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4433765PMC
June 2015

Preleukemia: the normal side of cancer.

Curr Opin Hematol 2015 Mar;22(2):77-84

Princess Margaret Cancer Centre, Toronto, Ontario, Canada.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1097/MOH.0000000000000111DOI Listing
March 2015

Tyrosine phosphorylation of the Lyn Src homology 2 (SH2) domain modulates its binding affinity and specificity.

Mol Cell Proteomics 2015 Mar 13;14(3):695-706. Epub 2015 Jan 13.

From the ‡Molecular Structure and Function, The Hospital For Sick Children, 686 Bay Street, Toronto, M5G 0A4, Canada; ‡‡Departments of Molecular Genetics, Medical Science Building, Room 4386, 1 King's College Circle, Toronto, ON M5S 1A8, Canada; **The Princess Margaret Cancer Center, 610 University Avenue, M5G 2M9, Toronto, Canada

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1074/mcp.M114.044404DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4349988PMC
March 2015

Nanomolar-Potency Small Molecule Inhibitor of STAT5 Protein.

ACS Med Chem Lett 2014 Nov 19;5(11):1202-1206. Epub 2014 Sep 19.

Department of Chemistry, University of Toronto Mississauga , Mississauga, Ontario L5L 1C6, Canada.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1021/ml500165rDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4234445PMC
November 2014

Immediate utility of two approved agents to target both the metabolic mevalonate pathway and its restorative feedback loop.

Cancer Res 2014 Sep 3;74(17):4772-82. Epub 2014 Jul 3.

Princess Margaret Cancer Centre, Toronto, Ontario, Canada. Department of Medical Biophysics, University of Toronto, Toronto, Ontario, Canada.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1158/0008-5472.CAN-14-0130DOI Listing
September 2014

Salvage induction chemotherapy after azacitdine treatment failure in patients who received azacitidine as a bridge to allogeneic stem cell transplantation.

Br J Haematol 2014 Jul 21;166(2):303-6. Epub 2014 Mar 21.

Division Medical Oncology & Haematology, Princess Margaret Cancer Centre, Toronto, Ontario, Canada.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/bjh.12844DOI Listing
July 2014

The Pim-1 protein kinase is an important regulator of MET receptor tyrosine kinase levels and signaling.

Mol Cell Biol 2014 Jul 28;34(13):2517-32. Epub 2014 Apr 28.

Department of Medicine, Medical University of South Carolina, Charleston, South Carolina, USA The Hollings Cancer Center, Medical University of South Carolina, Charleston, South Carolina, USA

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1128/MCB.00147-14DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4054323PMC
July 2014

Predictors of outcome in adults with BCR-ABL negative acute lymphoblastic leukemia treated with a pediatric-based regimen.

Leuk Res 2014 May 5;38(5):532-6. Epub 2013 Nov 5.

Department of Medical Oncology and Hematology, Princess Margaret Cancer Centre, University of Toronto, Toronto, ON, Canada.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.leukres.2013.10.025DOI Listing
May 2014

Therapeutic potential of spleen tyrosine kinase inhibition for treating high-risk precursor B cell acute lymphoblastic leukemia.

Sci Transl Med 2014 May;6(236):236ra62

Department of Medical Biophysics, University of Toronto, Toronto, Ontario M5S 1A8, Canada. Program in Genetics & Genome Biology, The Hospital for Sick Children, Toronto, Ontario M5G 1L7, Canada.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1126/scitranslmed.3008661DOI Listing
May 2014

A pilot phase II RCT of a home-based exercise intervention for survivors of AML.

Support Care Cancer 2014 Apr 16;22(4):881-9. Epub 2013 Nov 16.

Department of Medicine, University Health Network, Toronto, ON, Canada,

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s00520-013-2044-8DOI Listing
April 2014

Inhibition of glutaminase selectively suppresses the growth of primary acute myeloid leukemia cells with IDH mutations.

Exp Hematol 2014 Apr 11;42(4):247-51. Epub 2013 Dec 11.

Abramson Cancer Center, University of Pennsylvania, Philadelphia, PA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.exphem.2013.12.001DOI Listing
April 2014

Treatment of elderly patients with acute lymphoblastic leukaemia using a paediatric-based protocol.

Br J Haematol 2013 Nov 13;163(4):458-64. Epub 2013 Sep 13.

Department of Medical Oncology and Hematology, Princess Margaret Cancer Centre, University of Toronto, Toronto, ON, Canada.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/bjh.12561DOI Listing
November 2013

Symptom burden and supportive care in patients with acute leukemia.

Leuk Res 2013 Jul 11;37(7):731-6. Epub 2013 Mar 11.

Department of Psychosocial Oncology and Palliative Care, Princess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada.

View Article

Download full-text PDF

Source
http://linkinghub.elsevier.com/retrieve/pii/S014521261300047
Publisher Site
http://dx.doi.org/10.1016/j.leukres.2013.02.009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3808347PMC
July 2013

Cancer patient perceptions on the ethical and legal issues related to biobanking.

BMC Med Genomics 2013 Mar 8;6. Epub 2013 Mar 8.

Alden March Bioethics Institute, Albany Medical College, 47 New Scotland Avenue, MC 153, Albany, NY 12208-3478, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/1755-8794-6-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3599691PMC
March 2013