Mark Alkema

Mark Alkema

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Mark Alkema

Mark Alkema

Publications by authors named "Mark Alkema"

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33Publications

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Flexible motor sequence generation during stereotyped escape responses.

Elife 2020 Jun 5;9. Epub 2020 Jun 5.

Hefei National Laboratory for Physical Sciences at the Microscale, Center for Integrative Imaging, School of Life Sciences, University of Science and Technology of China, Hefei, China.

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http://dx.doi.org/10.7554/eLife.56942DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7338056PMC
June 2020

HIF-1 Has a Central Role in Organismal Response to Selenium.

Front Genet 2020 25;11:63. Epub 2020 Feb 25.

Laboratorio de Biología de Gusanos. Unidad Mixta, Departamento de Biociencias, Facultad de Química, Universidad de la República-Institut Pasteur de Montevideo, Montevideo, Uruguay.

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http://dx.doi.org/10.3389/fgene.2020.00063DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7052493PMC
February 2020

The flight response impairs cytoprotective mechanisms by activating the insulin pathway.

Nature 2019 09 28;573(7772):135-138. Epub 2019 Aug 28.

Department of Neurobiology, University of Massachusetts Medical School, Worcester, MA, USA.

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http://dx.doi.org/10.1038/s41586-019-1524-5DOI Listing
September 2019

Diapause induces functional axonal regeneration after necrotic insult in C. elegans.

PLoS Genet 2019 01 14;15(1):e1007863. Epub 2019 Jan 14.

Centro de Genómica y Bioinformática, Facultad de Ciencias, Universidad Mayor, Santiago de Chile, Chile.

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http://dx.doi.org/10.1371/journal.pgen.1007863DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6347329PMC
January 2019

Breakdown of Neural Function under Isoflurane Anesthesia: In Vivo, Multineuronal Imaging in Caenorhabditis elegans.

Anesthesiology 2018 10;129(4):733-743

From the Department of Physiology and Biophysics (M.R.A., D.A., C.V.G., C.W.C.) Department of Pharmacology and Experimental Therapeutics, Photonics Center (C.V.G.), Boston University School of Medicine, Boston, Massachusetts Department of Neurobiology, University of Massachusetts Medical School, Worcester, Massachusetts (J.F., M.A.) Department of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women's Hospital, Boston, Massachusetts (C.W.C.).

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http://dx.doi.org/10.1097/ALN.0000000000002342DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6148381PMC
October 2018

Neurexin directs partner-specific synaptic connectivity in .

Elife 2018 07 24;7. Epub 2018 Jul 24.

Department of Neurobiology, University of Massachusetts Medical School, Worcester, United States.

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http://dx.doi.org/10.7554/eLife.35692DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6057746PMC
July 2018

Selenoprotein T is required for pathogenic bacteria avoidance in Caenorhabditis elegans.

Free Radic Biol Med 2017 07 24;108:174-182. Epub 2017 Mar 24.

Worm Biology Laboratory, Institut Pasteur de Montevideo, Uruguay; Cátedra de Inmunología, Departamento de Biociencias, Facultad de Química, Universidad de la República, Montevideo, Uruguay. Electronic address:

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http://dx.doi.org/10.1016/j.freeradbiomed.2017.03.021DOI Listing
July 2017

The Genetic Basis of Natural Variation in Caenorhabditis elegans Telomere Length.

Genetics 2016 09 22;204(1):371-83. Epub 2016 Jul 22.

Department of Molecular Biosciences, Northwestern University, Evanston, Illinois 60208 Robert H. Lurie Comprehensive Cancer Center, Northwestern University, Chicago, Illinois 60611 Chemistry of Life Processes Institute, Northwestern University, Evanston, Illinois 60208 Northwestern Institute on Complex Systems, Northwestern University, Evanston, Illinois 60208

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http://dx.doi.org/10.1534/genetics.116.191148DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5012401PMC
September 2016

Imprinting: When Early Life Memories Make Food Smell Bad.

Curr Biol 2016 05;26(9):R362-4

Department of Neurobiology, University of Massachusetts Medical School, 364 Plantation Street, Worcester, MA 01605, USA. Electronic address:

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http://dx.doi.org/10.1016/j.cub.2016.03.032DOI Listing
May 2016

A Change in the Ion Selectivity of Ligand-Gated Ion Channels Provides a Mechanism to Switch Behavior.

PLoS Biol 2015 8;13(9):e1002238. Epub 2015 Sep 8.

Department of Neurobiology, University of Massachusetts Medical School, Worcester, Massachusetts, United States of America.

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http://dx.doi.org/10.1371/journal.pbio.1002238DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4562599PMC
April 2016

Pan-neuronal imaging in roaming Caenorhabditis elegans.

Proc Natl Acad Sci U S A 2016 Feb 28;113(8):E1082-8. Epub 2015 Dec 28.

Department of Physics, Harvard University, Cambridge, MA 02138; Center for Brain Science, Harvard University, Cambridge, MA 02138;

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http://dx.doi.org/10.1073/pnas.1507109113DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4776525PMC
February 2016

Caenorhabditis elegans exhibit a coupling between the defecation motor program and directed locomotion.

Sci Rep 2015 Nov 24;5:17174. Epub 2015 Nov 24.

The Institute for Biophysical Dynamics, The University of Chicago, Chicago, IL.

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http://dx.doi.org/10.1038/srep17174DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4657007PMC
November 2015

Illuminating neural circuits and behaviour in Caenorhabditis elegans with optogenetics.

Philos Trans R Soc Lond B Biol Sci 2015 Sep;370(1677):20140212

Department of Physics and Center for Brain Science, Harvard University, Cambridge, MA 02138, USA.

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http://rstb.royalsocietypublishing.org/lookup/doi/10.1098/rs
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http://dx.doi.org/10.1098/rstb.2014.0212DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4528824PMC
September 2015

The NCA sodium leak channel is required for persistent motor circuit activity that sustains locomotion.

Nat Commun 2015 Feb 26;6:6323. Epub 2015 Feb 26.

1] Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, Ontario, Canada M5G 1X5 [2] Institute of Medical Science, University of Toronto, Toronto, Ontario, Canada M5S 1A8 [3] Department of Physiology, University of Toronto, Toronto, Ontario, Canada M5S 1A8 [4] Department of Molecular Genetics, University of Toronto, Toronto, Ontario, Canada M5S 1A8.

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http://dx.doi.org/10.1038/ncomms7323DOI Listing
February 2015

Simultaneous optogenetic manipulation and calcium imaging in freely moving C. elegans.

Front Neural Circuits 2014 24;8:28. Epub 2014 Mar 24.

Lewis Sigler Institute for Integrative Genomics, Princeton University Princeton, NJ, USA.

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http://dx.doi.org/10.3389/fncir.2014.00028DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3970007PMC
September 2014

A conserved dopamine-cholecystokinin signaling pathway shapes context-dependent Caenorhabditis elegans behavior.

PLoS Genet 2014 Aug 28;10(8):e1004584. Epub 2014 Aug 28.

Department of Neurobiology, University of Massachusetts Medical School, Worcester, Massachusetts, United States of America.

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http://dx.doi.org/10.1371/journal.pgen.1004584DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4148232PMC
August 2014

Monoaminergic orchestration of motor programs in a complex C. elegans behavior.

PLoS Biol 2013 2;11(4):e1001529. Epub 2013 Apr 2.

Department of Neurobiology, University of Massachusetts Medical School, Worcester, Massachusetts, United States of America.

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http://dx.doi.org/10.1371/journal.pbio.1001529DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3614513PMC
October 2013

Intercellular calcium signaling in a gap junction-coupled cell network establishes asymmetric neuronal fates in C. elegans.

Development 2012 Nov;139(22):4191-201

Division of Developmental Biology, Children's Hospital Medical Center Research Foundation, 240 Albert Sabin Way, Cincinnati, OH 45229, USA.

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http://dev.biologists.org/cgi/doi/10.1242/dev.083428
Publisher Site
http://dx.doi.org/10.1242/dev.083428DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3478688PMC
November 2012

The neuroethology of C. elegans escape.

Curr Opin Neurobiol 2012 Apr 4;22(2):187-93. Epub 2012 Jan 4.

Department of Neurobiology, LRB 717, University of Massachusetts Medical School, Worcester, MA 01605, USA.

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http://dx.doi.org/10.1016/j.conb.2011.12.007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3437330PMC
April 2012

The C. elegans touch response facilitates escape from predacious fungi.

Curr Biol 2011 Aug 28;21(15):1326-30. Epub 2011 Jul 28.

Department of Neurobiology, University of Massachusetts Medical School, Worcester, MA 01605, USA.

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http://dx.doi.org/10.1016/j.cub.2011.06.063DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3266163PMC
August 2011

Autoregulatory and paracrine control of synaptic and behavioral plasticity by octopaminergic signaling.

Nat Neurosci 2011 Feb 26;14(2):190-9. Epub 2010 Dec 26.

Department of Neurobiology, University of Massachusetts Medical School, Worcester, Massachusetts, USA.

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http://dx.doi.org/10.1038/nn.2716DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3391700PMC
February 2011

Optogenetic manipulation of neural activity in freely moving Caenorhabditis elegans.

Nat Methods 2011 Feb 16;8(2):147-52. Epub 2011 Jan 16.

Department of Physics and Center for Brain Science, Harvard University, Cambridge, Massachusetts, USA.

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http://dx.doi.org/10.1038/nmeth.1554DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3032981PMC
February 2011

Oxygen sensation: into thick air.

Authors:
Mark J Alkema

Curr Biol 2009 May;19(10):R407-9

Department of Neurobiology, University of Massachusetts Medical School, 364 Plantation Street, Worcester, MA 01605, USA.

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http://dx.doi.org/10.1016/j.cub.2009.03.058DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3247071PMC
May 2009

Tyramine Functions independently of octopamine in the Caenorhabditis elegans nervous system.

Neuron 2005 Apr;46(2):247-60

Howard Hughes Medical Institute, Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.

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http://dx.doi.org/10.1016/j.neuron.2005.02.024DOI Listing
April 2005