Publications by authors named "Marjan Oustad"

4 Publications

  • Page 1 of 1

Effect of donepezil and memantine on improvement of cognitive function in patients with temporal lobe epilepsy.

J Res Med Sci 2020 18;25:29. Epub 2020 Mar 18.

Department of Neurology, Medical School, Isfahan University of Medical Sciences, Isfahan, Iran.

Background: Cognitive impairment is a common complication of patients with temporal lobe epilepsy (TLE). Therefore, the aim of this study was to compare the effects of donepezil and memantine on improving the cognitive function of patients with TLE.

Materials And Methods: In a clinical trial study, 70 patients with TLE were divided into two groups of 35 each: 10 mg doses of donepezil (first group) and memantine (second group) were applied for 16 weeks. The level of cognitive function of patients in both groups before and after treatment was determined using Montreal Cognitive Assessment (MoCA) test.

Results: The mean score of MoCA before and after intervention was 23.55 ± 3.67 and 26.09 ± 2.5, respectively, in the group treated with memantine, and the mean score of intervention was significantly improved ( < 0.001). In the group treated with donepezil, the score before and after the operation was 23.87 ± 3.18 and 24.35 ± 2.17, respectively, and no significant difference was observed in this group ( = 0.38).

Conclusion: Hence, memantine was better than donepezil in the improvement of cognitive impairment in patients with TLE.
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http://dx.doi.org/10.4103/jrms.JRMS_209_19DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7213001PMC
March 2020

Tumefactive rebound of multiple sclerosis after the short-term cessation of fingolimod: A case report.

Mult Scler Relat Disord 2019 Dec 6;39:101883. Epub 2019 Dec 6.

Pediatric Pathology research center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

Rebound syndrome can occur as a flare-up disease activity after stopping treatment in multiple sclerosis (MS). A potential rebound activity has recently been reported after fingolimod cessation with increasing clinical and radiographic activity, which makes decision-making about the discontinuation of treatment a major concern. This article reports on a patient with tumefactive rebound of MS who presented with acute onset encephalopathy and progressive motor deficiencies a few days after fingolimod cessation. Despite the invasive treatment, the disease progressed and resulted in the patient's death. This article discusses the clinical course of the disease and the MRI findings and compares them with the findings of previous reports. The present case shows that rebound activity can occur even after a short-term fingolimod withdrawal and may present with acute onset encephalopathy and aphasia.
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http://dx.doi.org/10.1016/j.msard.2019.101883DOI Listing
December 2019

Role of mesenchymal stem cells derived exosomes therapy in neuronal remodeling after ischemic stroke.

Minerva Med 2019 Oct 14. Epub 2019 Oct 14.

Department of Hematology, School of Medical Sciences, Tarbiat Modares University, Tehran, Iran -

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http://dx.doi.org/10.23736/S0026-4806.19.06277-3DOI Listing
October 2019

Demographic and Clinical Features of Pediatric Uveitis at a Tertiary Referral Center in Iran.

Middle East Afr J Ophthalmol 2016 Jul-Sep;23(3):237-40

Department of Pediatrics, Pediatrics Clinic, Shaheed Dastgheib Hospital, Shiraz University of Medical Sciences, Shiraz, Iran.

Purpose: To determine the clinical features and distribution of uveitis in the pediatric age group at a referral eye care center in Shiraz, South Iran.

Materials And Methods: All new cases of uveitis in patients 18-year-old or younger referred from January 2007 to December 2013 were enrolled in this study. The patient underwent a complete history of systemic and ocular diseases, comprehensive ophthalmic examination. Patients were classified according to the International Uveitis Study Group definitions. The definitive diagnosis was based on clinical manifestations and laboratory investigations.

Results: Seventy-seven eyes (54 patients) comprised the study sample. The mean age at the onset of uveitis was 12.5 years. The female-to-male ratio was 1.25. Anterior uveitis was the most frequent anatomical location (40.7%), followed by intermediate uveitis (33.3%), posterior uveitis (18.5%), and panuveitis (7.5%). Seventy-four percent of patients presented with chronic uveitis. Noninfectious uveitis (81.5%) was the most frequent etiology. Thirty-seven percent of patients had a specific diagnosis for uveitis, and 63% were classified as idiopathic cases. Toxocariasis was the most common infectious cause. Associated systemic diseases were present in 14.8% of patients. The most frequent systemic disease was juvenile idiopathic arthritis in 9.2% of patients. Complications occurred in 66 (85.5%) of affected eyes. The most common complications were posterior synechia (20.7%), cataract (18.8%), and cystoid macular edema (12.9%).

Conclusions: Uveitis in the majority of children had an insidious onset and was chronic. Over half the patients had a specific diagnosis. Idiopathic cases were more common in the intermediate uveitis group.
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http://dx.doi.org/10.4103/0974-9233.186096DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4968143PMC
March 2017