Marja L Mikkola

Marja L Mikkola

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Marja L Mikkola

Marja L Mikkola

Publications by authors named "Marja L Mikkola"

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Inductive signals in branching morphogenesis - lessons from mammary and salivary glands.

Curr Opin Cell Biol 2019 Dec 3;61:72-78. Epub 2019 Aug 3.

Developmental Biology Program, Institute of Biotechnology, HiLIFE, P.O.B. 56, University of Helsinki, 00014 Helsinki, Finland. Electronic address:

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http://dx.doi.org/10.1016/j.ceb.2019.07.001DOI Listing
December 2019

The Eleventh ENBDC Workshop: Advances in Technology Help to Unveil Mechanisms of Mammary Gland Development and Cancerogenesis.

J Mammary Gland Biol Neoplasia 2019 Sep 7;24(3):201-206. Epub 2019 Sep 7.

Department of Histology and Embryology, Faculty of Medicine, Masaryk University, Brno, Czech Republic.

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http://dx.doi.org/10.1007/s10911-019-09436-0DOI Listing
September 2019

Publisher Correction: FGF signalling controls the specification of hair placode-derived SOX9 positive progenitors to Merkel cells.

Nat Commun 2018 07 17;9(1):2854. Epub 2018 Jul 17.

Black Family Stem Cell Institute, Department of Cell, Developmental, and Regenerative Biology, Icahn School of Medicine at Mount Sinai, 1 Gustave L. Levy Place, New York, NY, 10029, USA.

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http://dx.doi.org/10.1038/s41467-018-05361-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6050296PMC
July 2018

FGF signalling controls the specification of hair placode-derived SOX9 positive progenitors to Merkel cells.

Nat Commun 2018 06 13;9(1):2333. Epub 2018 Jun 13.

Black Family Stem Cell Institute, Department of Cell, Developmental, and Regenerative Biology, Icahn School of Medicine at Mount Sinai, 1 Gustave L. Levy Place, New York, NY, 10029, USA.

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http://dx.doi.org/10.1038/s41467-018-04399-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5998134PMC
June 2018

In Utero Protein Therapy for an Inherited Developmental Disorder.

Authors:
Marja L Mikkola

N Engl J Med 2018 04;378(17):1637-1638

From the Developmental Biology Program, Institute of Biotechnology, University of Helsinki, Helsinki.

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http://dx.doi.org/10.1056/NEJMe1803224DOI Listing
April 2018

New insights into fetal mammary gland morphogenesis: differential effects of natural and environmental estrogens.

Sci Rep 2017 01 19;7:40806. Epub 2017 Jan 19.

Dept. of Integrated Physiology and Pathobiology, 136 Harrison Avenue, Tufts University School of Medicine, Boston MA 02111 USA.

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http://dx.doi.org/10.1038/srep40806DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5244390PMC
January 2017

Early epithelial signaling center governs tooth budding morphogenesis.

J Cell Biol 2016 Sep;214(6):753-67

Developmental Biology Program, Institute of Biotechnology, University of Helsinki, 00014 Helsinki, Finland

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http://dx.doi.org/10.1083/jcb.201512074DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5021093PMC
September 2016

Foxi3 Deficiency Compromises Hair Follicle Stem Cell Specification and Activation.

Stem Cells 2016 07 4;34(7):1896-908. Epub 2016 Apr 4.

Research Program in Developmental Biology, Institute of Biotechnology, University of Helsinki, Helsinki, Finland.

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http://doi.wiley.com/10.1002/stem.2363
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http://dx.doi.org/10.1002/stem.2363DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5287380PMC
July 2016

Suppression of epithelial differentiation by Foxi3 is essential for molar crown patterning.

Development 2015 Nov 8;142(22):3954-63. Epub 2015 Oct 8.

Research Program in Developmental Biology, Institute of Biotechnology, University of Helsinki, Biocenter 1, PO Box 56, Helsinki 00014, Finland

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http://dx.doi.org/10.1242/dev.124172DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6517835PMC
November 2015

Ectodysplasin/NF-κB Promotes Mammary Cell Fate via Wnt/β-catenin Pathway.

PLoS Genet 2015 Nov 18;11(11):e1005676. Epub 2015 Nov 18.

Developmental Biology Program, Institute of Biotechnology, University of Helsinki, Helsinki, Finland.

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http://dx.doi.org/10.1371/journal.pgen.1005676DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4651331PMC
November 2015

Early inductive events in ectodermal appendage morphogenesis.

Semin Cell Dev Biol 2014 Jan-Feb;25-26:11-21. Epub 2014 Jan 30.

Developmental Biology Program, Institute of Biotechnology, P.O. Box 56, University of Helsinki, 00014 Helsinki, Finland. Electronic address:

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http://dx.doi.org/10.1016/j.semcdb.2014.01.007DOI Listing
January 2015

Development of ectodermal organs.

Semin Cell Dev Biol 2014 Jan-Feb;25-26:1-2. Epub 2014 Feb 6.

Developmental Biology Program, Institute of Biotechnology, P.O. Box 56, University of Helsinki, 00014 Helsinki, Finland. Electronic address:

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http://dx.doi.org/10.1016/j.semcdb.2014.02.002DOI Listing
January 2015

Replaying evolutionary transitions from the dental fossil record.

Nature 2014 Aug 30;512(7512):44-8. Epub 2014 Jul 30.

Developmental Biology Program, Institute of Biotechnology, University of Helsinki, P.O. Box 56, FIN-00014 Helsinki, Finland.

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http://dx.doi.org/10.1038/nature13613DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4252015PMC
August 2014

Ectodysplasin research--where to next?

Semin Immunol 2014 Jun 10;26(3):220-8. Epub 2014 Jun 10.

Developmental Biology Program, Institute of Biotechnology, University of Helsinki, P.O.B. 56, 00014 Helsinki, Finland. Electronic address:

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http://dx.doi.org/10.1016/j.smim.2014.05.002DOI Listing
June 2014

Directional cell migration, but not proliferation, drives hair placode morphogenesis.

Dev Cell 2014 Mar;28(5):588-602

Developmental Biology Program, Institute of Biotechnology, 00014 University of Helsinki, Helsinki, Finland. Electronic address:

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http://dx.doi.org/10.1016/j.devcel.2014.02.003DOI Listing
March 2014

Expression of Foxi3 is regulated by ectodysplasin in skin appendage placodes.

Dev Dyn 2013 Jun 9;242(6):593-603. Epub 2013 Apr 9.

Developmental Biology Program, Institute of Biotechnology, University of Helsinki, Helsinki, Finland.

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http://dx.doi.org/10.1002/dvdy.23952DOI Listing
June 2013

Ectodysplasin/NF-κB signaling in embryonic mammary gland development.

J Mammary Gland Biol Neoplasia 2013 Jun 17;18(2):165-9. Epub 2013 Apr 17.

Developmental Biology Program, Institute of Biotechnology, University of Helsinki, P.O. Box 56, 00014, Helsinki, Finland.

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http://dx.doi.org/10.1007/s10911-013-9277-5DOI Listing
June 2013

Protocol: ex vivo culture of mouse embryonic mammary buds.

J Mammary Gland Biol Neoplasia 2013 Jun 15;18(2):239-45. Epub 2013 May 15.

Developmental Biology Program, Institute of Biotechnology, University of Helsinki, P.O. Box 56, 00014, Helsinki, Finland.

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http://dx.doi.org/10.1007/s10911-013-9288-2DOI Listing
June 2013

Ectodysplasin regulates activator-inhibitor balance in murine tooth development through Fgf20 signaling.

Development 2012 Sep 25;139(17):3189-99. Epub 2012 Jul 25.

Developmental Biology Program, Institute of Biotechnology, University of Helsinki, POB 56, 00014 Helsinki, Finland.

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http://dev.biologists.org/cgi/doi/10.1242/dev.079558
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http://dx.doi.org/10.1242/dev.079558DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3413164PMC
September 2012

Identification of ectodysplasin target genes reveals the involvement of chemokines in hair development.

J Invest Dermatol 2012 Apr 26;132(4):1094-102. Epub 2012 Jan 26.

Developmental Biology Program, Institute of Biotechnology, University of Helsinki, Helsinki, Finland.

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http://dx.doi.org/10.1038/jid.2011.453DOI Listing
April 2012

Ectodysplasin regulates hormone-independent mammary ductal morphogenesis via NF-κB.

Proc Natl Acad Sci U S A 2012 Apr 26;109(15):5744-9. Epub 2012 Mar 26.

Developmental Biology Program, Institute of Biotechnology, University of Helsinki, 00014 Helsinki, Finland.

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http://dx.doi.org/10.1073/pnas.1110627109DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3326516PMC
April 2012

Sostdc1 defines the size and number of skin appendage placodes.

Dev Biol 2012 Apr;364(2):149-61

Developmental Biology Program, Institute of Biotechnology, University of Helsinki, Helsinki, Finland.

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http://dx.doi.org/10.1016/j.ydbio.2012.01.026DOI Listing
April 2012

On the difficulty of increasing dental complexity.

Nature 2012 Mar 7;483(7389):324-7. Epub 2012 Mar 7.

Developmental Biology Program, Institute of Biotechnology, University of Helsinki, P.O. Box 56, FIN-00014 Helsinki, Finland.

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http://dx.doi.org/10.1038/nature10876DOI Listing
March 2012

Ectodysplasin and Wnt pathways are required for salivary gland branching morphogenesis.

Development 2011 Jul;138(13):2681-91

Developmental Biology Program, Institute of Biotechnology, University of Helsinki, P.O.B. 56, 00014 Helsinki, Finland.

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http://dev.biologists.org/content/develop/138/13/2681.full.p
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http://dev.biologists.org/cgi/doi/10.1242/dev.057711
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http://dx.doi.org/10.1242/dev.057711DOI Listing
July 2011

The Edar subfamily in hair and exocrine gland development.

Authors:
Marja L Mikkola

Adv Exp Med Biol 2011 ;691:23-33

Developmental Biology Program, Institute of Biotechnology, University of Helsinki, P.O. Box 56, 00014 Helsinki, Finland.

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http://dx.doi.org/10.1007/978-1-4419-6612-4_3DOI Listing
April 2011

Molecular aspects of hypohidrotic ectodermal dysplasia.

Authors:
Marja L Mikkola

Am J Med Genet A 2009 Sep;149A(9):2031-6

Developmental Biology Program, Institute of Biotechnology, University of Helsinki, 00014 Helsinki, Finland.

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http://dx.doi.org/10.1002/ajmg.a.32855DOI Listing
September 2009

Controlling the number of tooth rows.

Authors:
Marja L Mikkola

Sci Signal 2009 Aug 25;2(85):pe53. Epub 2009 Aug 25.

Institute of Biotechnology, University of Helsinki, Helsinki, Finland.

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http://dx.doi.org/10.1126/scisignal.285pe53DOI Listing
August 2009

Edar and Troy signalling pathways act redundantly to regulate initiation of hair follicle development.

Hum Mol Genet 2008 Nov 9;17(21):3380-91. Epub 2008 Aug 9.

Developmental Biology Program, Institute of Biotechnology, 00014 University of Helsinki, PO Box 56, Finland.

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http://dx.doi.org/10.1093/hmg/ddn232DOI Listing
November 2008

TNF superfamily in skin appendage development.

Authors:
Marja L Mikkola

Cytokine Growth Factor Rev 2008 Jun-Aug;19(3-4):219-30. Epub 2008 May 20.

Developmental Biology Program, Institute of Biotechnology, University of Helsinki, P.O. Box 56, 00014 Helsinki, Finland.

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http://dx.doi.org/10.1016/j.cytogfr.2008.04.008DOI Listing
September 2008

Identification of dkk4 as a target of Eda-A1/Edar pathway reveals an unexpected role of ectodysplasin as inhibitor of Wnt signalling in ectodermal placodes.

Dev Biol 2008 Aug 26;320(1):60-71. Epub 2008 Apr 26.

Institute of Biotechnology, Developmental Biology Program, University of Helsinki, 00014, Helsinki, Finland.

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http://dx.doi.org/10.1016/j.ydbio.2008.04.023DOI Listing
August 2008

Sustained epithelial beta-catenin activity induces precocious hair development but disrupts hair follicle down-growth and hair shaft formation.

Development 2008 Mar 6;135(6):1019-28. Epub 2008 Feb 6.

Developmental Biology Program, Institute of Biotechnology, Viikki Biocenter, University of Helsinki, FIN-00014, Helsinki, Finland.

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http://dx.doi.org/10.1242/dev.016550DOI Listing
March 2008

Genetic basis of skin appendage development.

Authors:
Marja L Mikkola

Semin Cell Dev Biol 2007 Apr 25;18(2):225-36. Epub 2007 Jan 25.

Developmental Biology Program, Institute of Biotechnology, P.O. Box 56 (Viikinkaari 9), University of Helsinki, 00014 Helsinki, Finland.

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http://dx.doi.org/10.1016/j.semcdb.2007.01.007DOI Listing
April 2007

p63 in skin appendage development.

Authors:
Marja L Mikkola

Cell Cycle 2007 Feb 3;6(3):285-90. Epub 2007 Feb 3.

Developmental Biology Program, Institute of Biotechnology, University of Helsinki, Finland.

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http://dx.doi.org/10.4161/cc.6.3.3798DOI Listing
February 2007

Ectodysplasin has a dual role in ectodermal organogenesis: inhibition of Bmp activity and induction of Shh expression.

Development 2007 Jan;134(1):117-25

Institute of Biotechnology, Developmental Biology Program, University of Helsinki, 00014 Helsinki, Finland.

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http://dev.biologists.org/cgi/doi/10.1242/dev.02708
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http://dx.doi.org/10.1242/dev.02708DOI Listing
January 2007

The mammary bud as a skin appendage: unique and shared aspects of development.

J Mammary Gland Biol Neoplasia 2006 Oct;11(3-4):187-203

Developmental Biology Program, Institute of Biotechnology, University of Helsinki, PO Box 56, Viikinkaari 9, Helsinki, 00014, Finland.

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http://dx.doi.org/10.1007/s10911-006-9029-xDOI Listing
October 2006

p63 regulates multiple signalling pathways required for ectodermal organogenesis and differentiation.

Development 2006 Apr 8;133(8):1553-63. Epub 2006 Mar 8.

Institute of Biotechnology, University of Helsinki, 00014 Helsinki, Finland.

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http://dx.doi.org/10.1242/dev.02325DOI Listing
April 2006

Tooth patterning and enamel formation can be manipulated by misexpression of TNF receptor Edar.

Dev Dyn 2004 Oct;231(2):432-40

Developmental Biology Programme, Institute of Biotechnology, Viikki Biocenter, University of Helsinki, Helsinki, Finland.

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http://dx.doi.org/10.1002/dvdy.20138DOI Listing
October 2004

Ectodysplasin A1 promotes placodal cell fate during early morphogenesis of ectodermal appendages.

Development 2004 Oct 15;131(20):4907-19. Epub 2004 Sep 15.

Developmental Biology Program, Institute of Biotechnology, PO Box 56 (Viikinkaari 9), University of Helsinki, Finland.

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http://dx.doi.org/10.1242/dev.01377DOI Listing
October 2004

Ectodysplasin signaling in development.

Cytokine Growth Factor Rev 2003 Jun-Aug;14(3-4):211-24

Developmental Biology Program, Institute of Biotechnology, Viikki Biocenter, University of Helsinki, PO Box 56, Helsinki 00014, Finland.

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http://dx.doi.org/10.1016/s1359-6101(03)00020-0DOI Listing
February 2004

Ectodysplasin, Edar and TNFRSF19 are expressed in complementary and overlapping patterns during mouse embryogenesis.

Gene Expr Patterns 2003 Oct;3(5):675-9

Developmental Biology Programme, Institute of Biotechnology, Viikki Biocenter, University of Helsinki, 00014, Helsinki, Finland.

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http://dx.doi.org/10.1016/s1567-133x(03)00092-9DOI Listing
October 2003

Stimulation of ectodermal organ development by Ectodysplasin-A1.

Dev Biol 2003 Jul;259(1):123-36

Developmental Biology Program, Institute of Biotechnology, Viikki Biocenter, University of Helsinki, 00014 Helsinki, Finland.

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http://dx.doi.org/10.1016/s0012-1606(03)00157-xDOI Listing
July 2003

Death receptor signaling giving life to ectodermal organs.

Sci STKE 2002 May 7;2002(131):pe22. Epub 2002 May 7.

Developmental Biology Program, Insitute of Biotechnology, Viikki Biocenter, PO Box 56, University of Helsinki, 00014 Helsinki, Finland.

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http://dx.doi.org/10.1126/stke.2002.131.pe22DOI Listing
May 2002