Publications by authors named "Mariusz Wasik"

100Publications

Cutting Edge: ROR1/CD19 Receptor Complex Promotes Growth of Mantle Cell Lymphoma Cells Independently of the B Cell Receptor-BTK Signaling Pathway.

J Immunol 2019 10 18;203(8):2043-2048. Epub 2019 Sep 18.

Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104;

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http://dx.doi.org/10.4049/jimmunol.1801327DOI Listing
October 2019

Dynamic Changes in Gene Mutational Landscape With Preservation of Core Mutations in Mantle Cell Lymphoma Cells.

Front Oncol 2019 3;9:568. Epub 2019 Jul 3.

Department of Pathology and Laboratory Medicine, Abramson Cancer Center, Perelman School of Medicine of the University of Pennsylvania, Philadelphia, PA, United States.

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http://dx.doi.org/10.3389/fonc.2019.00568DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6617136PMC
July 2019

Distinct miRNA profile in prognosis of early CTCL.

Authors:
Mariusz A Wasik

Blood 2018 02;131(7):711

University of Pennsylvania.

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http://dx.doi.org/10.1182/blood-2017-12-821520DOI Listing
February 2018

Chimeric Antigen Receptor T Cells in Refractory B-Cell Lymphomas.

N Engl J Med 2017 12 10;377(26):2545-2554. Epub 2017 Dec 10.

From the Lymphoma Program at the Abramson Cancer Center and the Division of Hematology-Oncology (S.J.S., J.S., E.A.C., S.D.N., A.R.M., D.L., D.L.P.), and the Department of Pathology and Laboratory Medicine (V.B., M.W., B.L.L., S.F.L., J.J.M., C.H.J.), Perelman School of Medicine, University of Pennsylvania, Philadelphia; Novartis Pharmaceuticals, Basel, Switzerland (Ö.A.); and Novartis Institutes for BioMedical Research, Cambridge, MA (J.L.B., I.P-M.).

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http://www.nejm.org/doi/10.1056/NEJMoa1708566
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http://dx.doi.org/10.1056/NEJMoa1708566DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5788566PMC
December 2017

From Pathology to Precision Medicine in Anaplastic Large Cell Lymphoma Expressing Anaplastic Lymphoma Kinase (ALK+ ALCL).

Cancers (Basel) 2017 Oct 16;9(10). Epub 2017 Oct 16.

Department of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.

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http://dx.doi.org/10.3390/cancers9100138DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5664077PMC
October 2017

Overcoming the Immunosuppressive Tumor Microenvironment of Hodgkin Lymphoma Using Chimeric Antigen Receptor T Cells.

Cancer Discov 2017 10 2;7(10):1154-1167. Epub 2017 Jun 2.

Center for Cellular Immunotherapies, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania.

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http://dx.doi.org/10.1158/2159-8290.CD-16-0850DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5628114PMC
October 2017

Marginal zone lymphoma-derived interfollicular diffuse large B-cell lymphoma harboring 20q12 chromosomal deletion and missense mutation of BIRC3 gene: a case report.

Diagn Pathol 2016 Dec 19;11(1):137. Epub 2016 Dec 19.

Department of Pathology and Laboratory Medicine, Hospital of the University of Pennsylvania, 7 E Gates Pavilion, 3400 Spruce Street, Philadelphia, 19104-4283, PA, USA.

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http://dx.doi.org/10.1186/s13000-016-0588-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5168845PMC
December 2016

Nucleophosmin-anaplastic lymphoma kinase: the ultimate oncogene and therapeutic target.

Blood 2017 02 22;129(7):823-831. Epub 2016 Nov 22.

Department of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, PA; and.

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http://dx.doi.org/10.1182/blood-2016-05-717793DOI Listing
February 2017

Malignant inflammation in cutaneous T-cell lymphoma-a hostile takeover.

Semin Immunopathol 2017 04 7;39(3):269-282. Epub 2016 Oct 7.

Department of Immunology and Microbiology, University of Copenhagen, Blegdamsvej 3c, DK-2200, Copenhagen N, Denmark.

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http://dx.doi.org/10.1007/s00281-016-0594-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5368200PMC
April 2017

(13)C MRS and LC-MS Flux Analysis of Tumor Intermediary Metabolism.

Front Oncol 2016 15;6:135. Epub 2016 Jun 15.

Laboratory of Molecular Imaging, Department of Radiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA; Department of Biochemistry and Biophysics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.

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http://dx.doi.org/10.3389/fonc.2016.00135DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4908130PMC
July 2016

IL-13 as a novel growth factor in CTCL.

Authors:
Mariusz A Wasik

Blood 2015 Apr;125(18):2737-8

UNIVERSITY OF PENNSYLVANIA.

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http://dx.doi.org/10.1182/blood-2015-02-626432DOI Listing
April 2015

Combined B12 and folate deficiency presenting as an aggressive hematologic malignancy.

Am J Hematol 2015 Oct 29;90(10):964-5. Epub 2015 Apr 29.

Division of Hematology and Oncology, University of Pennsylvania, Philadelphia, Pennsylvania.

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http://dx.doi.org/10.1002/ajh.23987DOI Listing
October 2015

PRMT5 is required for lymphomagenesis triggered by multiple oncogenic drivers.

Cancer Discov 2015 Mar 12;5(3):288-303. Epub 2015 Jan 12.

Department of Cancer Biology, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania.

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http://dx.doi.org/10.1158/2159-8290.CD-14-0625DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4355177PMC
March 2015

Development of lymphomas containing Epstein-Barr virus after therapy with hyper-CVAD regimen.

Clin Lymphoma Myeloma Leuk 2014 Apr 22;14(2):e55-8. Epub 2013 Nov 22.

Abramson Cancer Center, Division of Hematology and Oncology, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA.

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http://linkinghub.elsevier.com/retrieve/pii/S215226501300494
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http://dx.doi.org/10.1016/j.clml.2013.11.010DOI Listing
April 2014

Intravascular large B cell lymphoma presenting as a thyroid mass.

Endocr Pathol 2014 Sep;25(3):359-60

Department of Pathology and Laboratory Medicine, University of Pennsylvania, Perelman School of Medicine, Philadelphia, PA, USA,

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http://dx.doi.org/10.1007/s12022-013-9266-7DOI Listing
September 2014

Bacterial toxins fuel disease progression in cutaneous T-cell lymphoma.

Toxins (Basel) 2013 Aug 14;5(8):1402-21. Epub 2013 Aug 14.

Department of International Health, Immunology and Microbiology, University of Copenhagen, Copenhagen 2200, Denmark.

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http://dx.doi.org/10.3390/toxins5081402DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3760043PMC
August 2013

Elucidating the role of interleukin-17F in cutaneous T-cell lymphoma.

Blood 2013 Aug 25;122(6):943-50. Epub 2013 Jun 25.

Department of International Health, Immunology and Microbiology, University of Copenhagen, Blegdamsvej 3c, Copenhagen, Denmark.

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http://dx.doi.org/10.1182/blood-2013-01-480889DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3790948PMC
August 2013

Targeting CD30 in malignant tissues: challenges in detection and clinical applications.

Pathobiology 2013 9;80(5):252-8. Epub 2013 May 9.

Department of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, Pa., USA.

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http://dx.doi.org/10.1159/000347192DOI Listing
January 2014

The role of cytokine signaling in the pathogenesis of cutaneous T-cell lymphoma.

Cancer Biol Ther 2011 Dec 15;12(12):1019-22. Epub 2011 Dec 15.

Departments of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, PA, USA.

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http://dx.doi.org/10.4161/cbt.12.12.18144DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3679094PMC
December 2011

Simultaneous inhibition of mTOR-containing complex 1 (mTORC1) and MNK induces apoptosis of cutaneous T-cell lymphoma (CTCL) cells.

PLoS One 2011 16;6(9):e24849. Epub 2011 Sep 16.

Department of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0024849PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3174990PMC
January 2012

The Fbx4 tumor suppressor regulates cyclin D1 accumulation and prevents neoplastic transformation.

Mol Cell Biol 2011 Nov 12;31(22):4513-23. Epub 2011 Sep 12.

The Leonard and Madlyn Abramson Family Cancer Research Institute, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA.

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http://dx.doi.org/10.1128/MCB.05733-11DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3209253PMC
November 2011

IFN-α primes T- and NK-cells for IL-15-mediated signaling and cytotoxicity.

Mol Immunol 2011 Sep 2;48(15-16):2087-93. Epub 2011 Aug 2.

Department of International Health, Immunology and Microbiology, University of Copenhagen, Copenhagen, Denmark.

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http://dx.doi.org/10.1016/j.molimm.2011.07.008DOI Listing
September 2011

IL-2R common gamma-chain is epigenetically silenced by nucleophosphin-anaplastic lymphoma kinase (NPM-ALK) and acts as a tumor suppressor by targeting NPM-ALK.

Proc Natl Acad Sci U S A 2011 Jul 29;108(29):11977-82. Epub 2011 Jun 29.

Department of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.

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http://dx.doi.org/10.1073/pnas.1100319108DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3141982PMC
July 2011

Epstein-Barr Virus nuclear antigen 1 (EBNA1) confers resistance to apoptosis in EBV-positive B-lymphoma cells through up-regulation of survivin.

Virology 2011 Feb 19;410(1):64-75. Epub 2010 Nov 19.

Department of Microbiology and Tumor Virology Program, Abramson Comprehensive Cancer Center, School of Medicine, University of Pennsylvania, 202E Johnson Pavilion, 3610 Hamilton Walk, Philadelphia, PA 19104, USA.

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http://dx.doi.org/10.1016/j.virol.2010.10.029DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4287362PMC
February 2011

A systematic review of factors that contribute to hepatosplenic T-cell lymphoma in patients with inflammatory bowel disease.

Clin Gastroenterol Hepatol 2011 Jan 1;9(1):36-41.e1. Epub 2010 Oct 1.

Department of Medicine, Montefiore Medical Center, Albert Einstein College of Medicine, Bronx, NY, USA.

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http://dx.doi.org/10.1016/j.cgh.2010.09.016DOI Listing
January 2011

Deficient SOCS3 and SHP-1 expression in psoriatic T cells.

J Invest Dermatol 2010 Jun 4;130(6):1590-7. Epub 2010 Feb 4.

Department of International Health, Immunology and Microbiology, University of Copenhagen, Blegdamsvej 3c,Copenhagen, Denmark.

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http://dx.doi.org/10.1038/jid.2010.6DOI Listing
June 2010

Lack of TNFalpha expression protects anaplastic lymphoma kinase-positive T-cell lymphoma (ALK+ TCL) cells from apoptosis.

Proc Natl Acad Sci U S A 2009 Sep 26;106(37):15843-8. Epub 2009 Aug 26.

Department of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.

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http://dx.doi.org/10.1073/pnas.0907070106DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2747206PMC
September 2009

Activation of mTORC1 signaling pathway in AIDS-related lymphomas.

Am J Pathol 2009 Aug 16;175(2):817-24. Epub 2009 Jul 16.

University of Pennsylvania Medical Center, Department of Pathology and Laboratory Medicine, 3400 Spruce Street, 7.106 Founders Pavilion, Philadelphia, PA 19104, USA.

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http://dx.doi.org/10.2353/ajpath.2009.080451DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2716976PMC
August 2009

Anaplastic lymphoma kinase (ALK)-induced malignancies: novel mechanisms of cell transformation and potential therapeutic approaches.

Semin Oncol 2009 Apr;36(2 Suppl 1):S27-35

Department of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, PA, USA.

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http://dx.doi.org/10.1053/j.seminoncol.2009.02.007DOI Listing
April 2009

Oncogenic kinase NPM/ALK induces through STAT3 expression of immunosuppressive protein CD274 (PD-L1, B7-H1).

Proc Natl Acad Sci U S A 2008 Dec 16;105(52):20852-7. Epub 2008 Dec 16.

Department of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.

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http://dx.doi.org/10.1073/pnas.0810958105DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2634900PMC
December 2008

The combination of IL-21 and IFN-alpha boosts STAT3 activation, cytotoxicity and experimental tumor therapy.

Mol Immunol 2009 Feb 22;46(5):812-20. Epub 2008 Oct 22.

Institute of International Health, Immunology and Microbiology, Panum 22.5.40, University of Copenhagen, Blegdamsvej 3c, DK-2200 Copenhagen N, Denmark.

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http://linkinghub.elsevier.com/retrieve/pii/S016158900800663
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http://dx.doi.org/10.1016/j.molimm.2008.09.006DOI Listing
February 2009

Successful treatment of relapsed lymphomatoid granulomatosis with bexarotene.

Cancer Biol Ther 2008 Oct 21;7(10):1544-6. Epub 2008 Oct 21.

Abramson Cancer Center, Hospital of the University of Pennsylvania, University of Pennsylvania, Philadelphia, PA 19104, USA.

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http://dx.doi.org/10.4161/cbt.7.10.6834DOI Listing
October 2008

Detection of Epstein-Barr virus in T-cell prolymphocytic leukemia cells in vitro.

J Clin Virol 2008 Nov 14;43(3):260-5. Epub 2008 Sep 14.

Department of Microbiology and the Tumor Virology Program of Abramson Comprehensive Cancer Center, University of Pennsylvania Medical School, 201E Johnson Pavilion, Philadelphia, PA 19104, U S.

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http://dx.doi.org/10.1016/j.jcv.2008.07.018DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4289600PMC
November 2008

Central photopenic lesions on FDG-PET scan in a patient with peripheral T cell lymphoma.

Ann Nucl Med 2008 Aug 29;22(7):629-33. Epub 2008 Aug 29.

Division of Nuclear Medicine, Hospital of the University of Pennsylvania, 3400 Spruce Street, 110 Donner Bldg., Philadelphia, PA 19104, USA.

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http://dx.doi.org/10.1007/s12149-008-0164-xDOI Listing
August 2008

Successful use of the anti-CD25 antibody daclizumab in an adult patient with hemophagocytic lymphohistiocytosis.

Am J Hematol 2008 Sep;83(9):747-9

Hematologic Malignancies Program, Abramson Cancer Center, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA.

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http://doi.wiley.com/10.1002/ajh.21236
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http://dx.doi.org/10.1002/ajh.21236DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2757271PMC
September 2008

Differential effects of interleukin-2 and interleukin-15 versus interleukin-21 on CD4+ cutaneous T-cell lymphoma cells.

Cancer Res 2008 Feb;68(4):1083-91

Department of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA.

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http://dx.doi.org/10.1158/0008-5472.CAN-07-2403DOI Listing
February 2008

STAT5A is epigenetically silenced by the tyrosine kinase NPM1-ALK and acts as a tumor suppressor by reciprocally inhibiting NPM1-ALK expression.

Nat Med 2007 Nov 7;13(11):1341-8. Epub 2007 Oct 7.

Department of Pathology and Laboratory Medicine, University of Pennsylvania, 3400 Spruce Street, Philadelphia, Pennsylvania 19104-4283, USA.

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http://dx.doi.org/10.1038/nm1659DOI Listing
November 2007

IL-21 enhances antitumor responses without stimulating proliferation of malignant T cells of patients with Sézary syndrome.

J Invest Dermatol 2008 Feb 23;128(2):473-80. Epub 2007 Aug 23.

Department of Dermatology, University of Pennsylvania, Philadelphia, Pennsylvania, USA.

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http://dx.doi.org/10.1038/sj.jid.5701027DOI Listing
February 2008

Loss of SHP-1 tyrosine phosphatase expression correlates with the advanced stages of cutaneous T-cell lymphoma.

Hum Pathol 2007 Mar 19;38(3):462-7. Epub 2007 Jan 19.

Department of Pathology, Jefferson Medical College, Philadelphia, PA 19107, USA.

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http://dx.doi.org/10.1016/j.humpath.2006.09.012DOI Listing
March 2007

PU.1 activates transcription of SHP-1 gene in hematopoietic cells.

J Biol Chem 2007 Mar 11;282(9):6316-23. Epub 2007 Jan 11.

Department of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA.

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http://dx.doi.org/10.1074/jbc.M607526200DOI Listing
March 2007

Constitutive activation of mTOR signaling pathway in post-transplant lymphoproliferative disorders.

Lab Invest 2007 Jan 30;87(1):29-39. Epub 2006 Oct 30.

Department of Pathology and Laboratory Medicine, University of Pennsylvania Medical Center, Philadelphia, PA 19104, USA.

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http://dx.doi.org/10.1038/labinvest.3700494DOI Listing
January 2007

Peroxisome proliferator-activated receptor gamma promotes lymphocyte survival through its actions on cellular metabolic activities.

J Immunol 2006 Sep;177(6):3737-45

Department of Pathology and Laboratory Medicine, Weill Medical College of Cornell University, New York, NY 10021, USA.

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http://dx.doi.org/10.4049/jimmunol.177.6.3737DOI Listing
September 2006

STAT3 induces transcription of the DNA methyltransferase 1 gene (DNMT1) in malignant T lymphocytes.

Blood 2006 Aug;108(3):1058-64

Department of Pathology and Laboratory Medicine, University of Pennsylvania Medical Center, 7.103 Founders, Philadelphia, 19104, USA.

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http://dx.doi.org/10.1182/blood-2005-08-007377DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1895864PMC
August 2006