Marius Wernig

Marius Wernig

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Marius Wernig

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Modeling Alzheimer's disease with human iPS cells: advancements, lessons, and applications.

Neurobiol Dis 2019 Oct 13;130:104503. Epub 2019 Jun 13.

Department of Molecular and Cellular Physiology, Stanford University Medical School, Stanford, CA 94305, United States of America. Electronic address:

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http://dx.doi.org/10.1016/j.nbd.2019.104503DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6689423PMC
October 2019

Differential Signaling Mediated by ApoE2, ApoE3, and ApoE4 in Human Neurons Parallels Alzheimer's Disease Risk.

J Neurosci 2019 Sep 22;39(37):7408-7427. Epub 2019 Jul 22.

Department of Molecular and Cellular Physiology and Howard Hughes Medical Institute, Stanford University Medical School, Stanford, California 94305,

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http://dx.doi.org/10.1523/JNEUROSCI.2994-18.2019DOI Listing
September 2019

Neuroligin-4 Regulates Excitatory Synaptic Transmission in Human Neurons.

Neuron 2019 Aug 27;103(4):617-626.e6. Epub 2019 Jun 27.

Department of Pathology, Stanford University School of Medicine, Stanford, CA 94305, USA; Institute for Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA. Electronic address:

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http://dx.doi.org/10.1016/j.neuron.2019.05.043DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6706319PMC
August 2019

Direct Reprogramming of Human Neurons Identifies MARCKSL1 as a Pathogenic Mediator of Valproic Acid-Induced Teratogenicity.

Cell Stem Cell 2019 Jul 30;25(1):103-119.e6. Epub 2019 May 30.

Department of Molecular and Cellular Physiology and Howard Hughes Medical Institute, Stanford University School of Medicine, Stanford, CA 94305, USA. Electronic address:

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http://dx.doi.org/10.1016/j.stem.2019.04.021DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6609489PMC
July 2019

Reversible Disruption of Specific Transcription Factor-DNA Interactions Using CRISPR/Cas9.

Mol Cell 2019 May;74(3):622-633.e4

Department of Biology, Stanford University, Stanford, CA 94305, USA. Electronic address:

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http://dx.doi.org/10.1016/j.molcel.2019.04.011DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6599634PMC
May 2019

Direct targeting of the mouse optic nerve for therapeutic delivery.

J Neurosci Methods 2019 Feb 31;313:1-5. Epub 2018 Oct 31.

Department of Ophthalmology, Stanford University School of Medicine, Palo Alto, CA, USA; Department of Neurology, Stanford University School of Medicine, Palo Alto, CA, USA. Electronic address:

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http://dx.doi.org/10.1016/j.jneumeth.2018.10.038DOI Listing
February 2019

TFAP2C- and p63-Dependent Networks Sequentially Rearrange Chromatin Landscapes to Drive Human Epidermal Lineage Commitment.

Cell Stem Cell 2019 Feb 24;24(2):271-284.e8. Epub 2019 Jan 24.

Program in Epithelial Biology and Department of Dermatology, Stanford University School of Medicine, Stanford, CA 94305, USA; Center for Definitive and Curative Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA; Institute for Stem Cell Biology and Regenerative Medicine, Department of Pathology, Stanford University School of Medicine, Stanford, CA 94305, USA. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S19345909183060
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http://dx.doi.org/10.1016/j.stem.2018.12.012DOI Listing
February 2019

New Approaches, New Opportunities at the 2019 ISSCR Annual Meeting.

Stem Cell Reports 2018 12;11(6):1305

2019 ISSCR Program Committee Chair.

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http://dx.doi.org/10.1016/j.stemcr.2018.11.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6294715PMC
December 2018

CRISPR Activation Screens Systematically Identify Factors that Drive Neuronal Fate and Reprogramming.

Cell Stem Cell 2018 11 11;23(5):758-771.e8. Epub 2018 Oct 11.

Department of Bioengineering, Stanford University, Stanford, CA 94305, USA; Department of Chemical and Systems Biology, Stanford University, Stanford, CA 94305, USA; Stanford ChEM-H, Stanford University, Stanford, CA 94305, USA. Electronic address:

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http://dx.doi.org/10.1016/j.stem.2018.09.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6214761PMC
November 2018

The fragile X mutation impairs homeostatic plasticity in human neurons by blocking synaptic retinoic acid signaling.

Sci Transl Med 2018 08;10(452)

Departments of Neurosurgery, and Psychiatry and Behavioral Sciences, Stanford University School of Medicine, 265 Campus Drive, Stanford, CA 94305-5453, USA.

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http://dx.doi.org/10.1126/scitranslmed.aar4338DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6317709PMC
August 2018

Transdifferentiation of human adult peripheral blood T cells into neurons.

Proc Natl Acad Sci U S A 2018 06 4;115(25):6470-6475. Epub 2018 Jun 4.

Department of Pathology, Stanford University, Stanford, CA 94305;

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http://dx.doi.org/10.1073/pnas.1720273115DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6016798PMC
June 2018

Profiling DNA-transcription factor interactions.

Nat Biotechnol 2018 06;36(6):501-502

Department of Bioengineering, Stanford University, Stanford, California, USA.

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http://dx.doi.org/10.1038/nbt.4161DOI Listing
June 2018

The novel tool of cell reprogramming for applications in molecular medicine.

J Mol Med (Berl) 2017 07 8;95(7):695-703. Epub 2017 Jun 8.

Department of Pathology and Institute for Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine, Stanford, CA, 94305, USA.

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http://dx.doi.org/10.1007/s00109-017-1550-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5487694PMC
July 2017

Unique versus Redundant Functions of Neuroligin Genes in Shaping Excitatory and Inhibitory Synapse Properties.

J Neurosci 2017 07 12;37(29):6816-6836. Epub 2017 Jun 12.

Department of Molecular and Cellular Physiology and Howard Hughes Medical Institute, and.

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http://dx.doi.org/10.1523/JNEUROSCI.0125-17.2017DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5518416PMC
July 2017

Generation of pure GABAergic neurons by transcription factor programming.

Nat Methods 2017 Jun 15;14(6):621-628. Epub 2017 May 15.

Institute for Stem Cell Biology and Regenerative Medicine and Department of Pathology, Stanford University School of Medicine, Stanford, California, USA.

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http://dx.doi.org/10.1038/nmeth.4291DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5567689PMC
June 2017

Myt1l safeguards neuronal identity by actively repressing many non-neuronal fates.

Nature 2017 04 5;544(7649):245-249. Epub 2017 Apr 5.

Department of Pathology and Institute for Stem Cell Biology and Regenerative Medicine, Stanford University, Stanford, California 94305, USA.

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http://dx.doi.org/10.1038/nature21722DOI Listing
April 2017

Partial Reprogramming of Pluripotent Stem Cell-Derived Cardiomyocytes into Neurons.

Sci Rep 2017 03 22;7:44840. Epub 2017 Mar 22.

Stanford Cardiovascular Institute, Stanford University School of Medicine, Stanford, CA, USA.

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http://dx.doi.org/10.1038/srep44840DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5361100PMC
March 2017

Concise Review: Stem Cell-Based Treatment of Pelizaeus-Merzbacher Disease.

Stem Cells 2017 02 23;35(2):311-315. Epub 2016 Nov 23.

Center for Basic and Translational Neuroscience, University of Copenhagen, Copenhagen, Denmark.

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http://dx.doi.org/10.1002/stem.2530DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5314962PMC
February 2017

ApoE2, ApoE3, and ApoE4 Differentially Stimulate APP Transcription and Aβ Secretion.

Cell 2017 01 19;168(3):427-441.e21. Epub 2017 Jan 19.

Department of Molecular and Cellular Physiology and Howard Hughes Medical Institute, Stanford University Medical School, Stanford, CA 94305, USA. Electronic address:

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http://dx.doi.org/10.1016/j.cell.2016.12.044DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5310835PMC
January 2017

In Vivo Reprogramming for Brain and Spinal Cord Repair.

eNeuro 2015 Sep-Oct;2(5). Epub 2015 Nov 9.

Department of Molecular Biology, Hamon Center for Regenerative Science and Medicine, University of Texas Southwestern Medical Center , Dallas, Texas 75390.

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http://dx.doi.org/10.1523/ENEURO.0106-15.2015DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4699832PMC
September 2016

FoxO3 regulates neuronal reprogramming of cells from postnatal and aging mice.

Proc Natl Acad Sci U S A 2016 07 11;113(30):8514-9. Epub 2016 Jul 11.

Institute for Stem Cell Biology and Regenerative Medicine and Department of Pathology, Stanford University School of Medicine, Stanford, CA 94305;

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http://dx.doi.org/10.1073/pnas.1607079113DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4968717PMC
July 2016

Autism-associated SHANK3 haploinsufficiency causes Ih channelopathy in human neurons.

Science 2016 May 10;352(6286):aaf2669. Epub 2016 Mar 10.

Department of Molecular and Cellular Physiology, Stanford University School of Medicine, 265 Campus Drive, Stanford, CA 94305, USA. Howard Hughes Medical Institute, Stanford University School of Medicine, 265 Campus Drive, Stanford, CA 94305, USA.

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http://dx.doi.org/10.1126/science.aaf2669DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4901875PMC
May 2016

Conditional deletion of L1CAM in human neurons impairs both axonal and dendritic arborization and action potential generation.

J Exp Med 2016 Apr 21;213(4):499-515. Epub 2016 Mar 21.

Department of Molecular and Cellular Physiology, Stanford University School of Medicine, Stanford, CA 94305 Howard Hughes Medical Institute, Stanford University School of Medicine, Stanford, CA 94305.

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http://dx.doi.org/10.1084/jem.20150951DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4821644PMC
April 2016

Crosstalk between stem cell and cell cycle machineries.

Curr Opin Cell Biol 2015 Dec 11;37:68-74. Epub 2015 Nov 11.

Department of Pathology, Stanford University, Stanford, CA 94305, USA; Stanford Institute for Stem Cell Biology and Regenerative Medicine, Stanford University, Stanford, CA 94305, USA. Electronic address:

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http://dx.doi.org/10.1016/j.ceb.2015.10.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4852861PMC
December 2015

Direct somatic lineage conversion.

Philos Trans R Soc Lond B Biol Sci 2015 Oct;370(1680):20140368

Institute for Stem Cell Biology and Regenerative Medicine and Department of Pathology, Stanford University School of Medicine, Stanford, CA 94305, USA

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http://dx.doi.org/10.1098/rstb.2014.0368DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4633997PMC
October 2015

Human Neuropsychiatric Disease Modeling using Conditional Deletion Reveals Synaptic Transmission Defects Caused by Heterozygous Mutations in NRXN1.

Cell Stem Cell 2015 Sep 13;17(3):316-28. Epub 2015 Aug 13.

Department of Molecular and Cellular Physiology, Stanford University School of Medicine, 265 Campus Drive, Stanford, CA 94305, USA; Howard Hughes Medical Institute, Stanford University School of Medicine, 265 Campus Drive, Stanford, CA 94305, USA. Electronic address:

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http://dx.doi.org/10.1016/j.stem.2015.07.017DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4560990PMC
September 2015

Hallmarks of pluripotency.

Nature 2015 Sep;525(7570):469-78

Stem Cell Transplantation Program, Division of Pediatric Hematology Oncology, Children's Hospital Boston, and Dana-Farber Cancer Institute; Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, Massachusetts 02115, USA.

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http://dx.doi.org/10.1038/nature15515DOI Listing
September 2015

Failure to replicate the STAP cell phenomenon.

Nature 2015 Sep;525(7570):E6-9

Stem Cell Transplantation Program, Division of Pediatric Hematology Oncology, Children's Hospital Boston, and Dana-Farber Cancer Institute, Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, Massachusetts 02115, USA.

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http://dx.doi.org/10.1038/nature15513DOI Listing
September 2015

Early reprogramming regulators identified by prospective isolation and mass cytometry.

Nature 2015 May 1;521(7552):352-6. Epub 2015 Apr 1.

1] Institute for Stem Cell Biology and Regenerative Medicine, Stanford University, Stanford, California 94305, USA [2] Department of Pathology, Stanford University, Stanford, California 94305, USA.

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http://dx.doi.org/10.1038/nature14274DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4441548PMC
May 2015

A continuous molecular roadmap to iPSC reprogramming through progression analysis of single-cell mass cytometry.

Cell Stem Cell 2015 Mar;16(3):323-37

Department of Microbiology and Immunology, Baxter Laboratory for Stem Cell Biology, Stanford University School of Medicine, Stanford, CA 94305, USA. Electronic address:

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http://dx.doi.org/10.1016/j.stem.2015.01.015DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4401090PMC
March 2015

Inhibition of pluripotency networks by the Rb tumor suppressor restricts reprogramming and tumorigenesis.

Cell Stem Cell 2015 Jan 13;16(1):39-50. Epub 2014 Nov 13.

Department of Pathology, Stanford University, Stanford, CA 94305, USA; Stanford Institute for Stem Cell Biology and Regenerative Medicine, Stanford University, Stanford, CA 94305, USA. Electronic address:

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http://dx.doi.org/10.1016/j.stem.2014.10.019DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4389904PMC
January 2015

m(6)A RNA modification controls cell fate transition in mammalian embryonic stem cells.

Cell Stem Cell 2014 Dec 16;15(6):707-19. Epub 2014 Oct 16.

Howard Hughes Medical Institute and Program in Epithelial Biology, Stanford University School of Medicine, Stanford, CA 94305, USA. Electronic address:

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http://dx.doi.org/10.1016/j.stem.2014.09.019DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4278749PMC
December 2014

Induced neuronal reprogramming.

J Comp Neurol 2014 Aug 21;522(12):2877-86. Epub 2014 May 21.

Institute for Stem Cell Biology and Regenerative Medicine and Department of Pathology, Stanford University School of Medicine, Stanford, California, 94305; Department of Bioengineering, Stanford University School of Medicine, Stanford, California, 94305.

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http://dx.doi.org/10.1002/cne.23620DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4099045PMC
August 2014

Generation of induced neuronal cells by the single reprogramming factor ASCL1.

Stem Cell Reports 2014 Aug 4;3(2):282-96. Epub 2014 Jul 4.

Institute for Stem Cell Biology and Regenerative Medicine and Department of Pathology, Stanford University, Stanford, CA 94305, USA. Electronic address:

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http://dx.doi.org/10.1016/j.stemcr.2014.05.020DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4176533PMC
August 2014

Calcineurin signaling regulates neural induction through antagonizing the BMP pathway.

Neuron 2014 Apr;82(1):109-124

Department of Pathology, Stanford University School of Medicine, 300 Pasteur Drive, Stanford, California 94305, USA.

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http://dx.doi.org/10.1016/j.neuron.2014.02.015DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4011666PMC
April 2014

Harnessing the stem cell potential: a case for neural stem cell therapy.

Nat Med 2013 Dec;19(12):1580-1

Institute for Stem Cell Biology and Regenerative Medicine, Department of Pathology, Stanford University School of Medicine, Stanford, California, USA.

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http://dx.doi.org/10.1038/nm.3425DOI Listing
December 2013

Neurons generated by direct conversion of fibroblasts reproduce synaptic phenotype caused by autism-associated neuroligin-3 mutation.

Proc Natl Acad Sci U S A 2013 Oct 17;110(41):16622-7. Epub 2013 Sep 17.

Departments of Molecular and Cellular Physiology and Pathology, Howard Hughes Medical Institute, and Institute for Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine, Stanford, CA 94305.

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http://dx.doi.org/10.1073/pnas.1316240110DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3799342PMC
October 2013

Hierarchical mechanisms for direct reprogramming of fibroblasts to neurons.

Cell 2013 Oct 24;155(3):621-35. Epub 2013 Oct 24.

Howard Hughes Medical Institute and Program in Epithelial Biology, Stanford University, Stanford, CA 94305, USA; Program in Cancer Biology, Stanford University, Stanford, CA 94305, USA.

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http://dx.doi.org/10.1016/j.cell.2013.09.028DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3871197PMC
October 2013

Acute reduction in oxygen tension enhances the induction of neurons from human fibroblasts.

J Neurosci Methods 2013 Jun 3;216(2):104-9. Epub 2013 Apr 3.

Institute for Stem Cell Biology and Regenerative Medicine, Stanford, CA 94305, USA.

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http://dx.doi.org/10.1016/j.jneumeth.2013.03.020DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4009399PMC
June 2013

Generation of oligodendroglial cells by direct lineage conversion.

Nat Biotechnol 2013 May 14;31(5):434-9. Epub 2013 Apr 14.

Institute for Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine, Stanford, California, USA.

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http://dx.doi.org/10.1038/nbt.2564DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3677690PMC
May 2013

The many roads to Rome: induction of neural precursor cells from fibroblasts.

Curr Opin Genet Dev 2012 Oct 4;22(5):517-22. Epub 2012 Aug 4.

Institute for Stem Cell Biology and Regenerative Medicine, Department of Pathology, Stanford University School of Medicine, Stanford, CA 94305, USA.

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http://dx.doi.org/10.1016/j.gde.2012.07.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4109718PMC
October 2012

Molecular roadblocks for cellular reprogramming.

Mol Cell 2012 Sep;47(6):827-38

Institute for Stem Cell Biology and Regenerative Medicine, Department of Pathology, and Cancer Biology Program, Stanford University School of Medicine, Stanford, CA 94305, USA.

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http://dx.doi.org/10.1016/j.molcel.2012.09.008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3809030PMC
September 2012

Direct conversion of mouse fibroblasts to self-renewing, tripotent neural precursor cells.

Proc Natl Acad Sci U S A 2012 Feb 30;109(7):2527-32. Epub 2012 Jan 30.

Institute for Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA.

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http://dx.doi.org/10.1073/pnas.1121003109DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3289376PMC
February 2012

Induced neuronal cells: how to make and define a neuron.

Cell Stem Cell 2011 Dec;9(6):517-25

Institute for Stem Cell Biology and Regenerative Medicine, Department of Pathology, Stanford University School of Medicine, Stanford, CA 94305, USA.

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http://dx.doi.org/10.1016/j.stem.2011.11.015DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4377331PMC
December 2011

Comprehensive qPCR profiling of gene expression in single neuronal cells.

Nat Protoc 2011 Dec 22;7(1):118-27. Epub 2011 Dec 22.

Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, California, USA.

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http://dx.doi.org/10.1038/nprot.2011.430DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4377330PMC
December 2011

Cellular reprogramming: recent advances in modeling neurological diseases.

J Neurosci 2011 Nov;31(45):16070-5

Institute for Cell Engineering, Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA.

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http://dx.doi.org/10.1523/JNEUROSCI.4218-11.2011DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3236609PMC
November 2011

Direct lineage conversion of terminally differentiated hepatocytes to functional neurons.

Cell Stem Cell 2011 Oct 29;9(4):374-82. Epub 2011 Sep 29.

Institute for Stem Cell Biology and Regenerative Medicine and Department of Pathology, Stanford University School of Medicine, CA 94305, USA.

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http://dx.doi.org/10.1016/j.stem.2011.09.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3218088PMC
October 2011

Direct lineage conversions: unnatural but useful?

Nat Biotechnol 2011 Oct;29(10):892-907

Department of Pathology, Stanford University School of Medicine, Stanford, CA, USA.

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http://dx.doi.org/10.1038/nbt.1946DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3222779PMC
October 2011

Induction of human neuronal cells by defined transcription factors.

Nature 2011 May 26;476(7359):220-3. Epub 2011 May 26.

Department of Molecular and Cellular Physiology, Stanford University School of Medicine, 265 Campus Drive, Stanford, California 94305, USA.

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http://rwjms1.umdnj.edu/pang/Publications/hIN_nature10202_Pa
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http://www.nature.com/doifinder/10.1038/nature10202
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http://dx.doi.org/10.1038/nature10202DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3159048PMC
May 2011

On the streets of San Francisco: highlights from the ISSCR Annual Meeting 2010.

Cell Stem Cell 2010 Oct;7(4):443-50

Monash Immunology and Stem Cell Laboratories, Monash University, Clayton, Victoria, 3800, Australia.

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http://dx.doi.org/10.1016/j.stem.2010.09.002DOI Listing
October 2010

An imprinted signature helps isolate ESC-equivalent iPSCs.

Cell Res 2010 Sep 10;20(9):974-6. Epub 2010 Aug 10.

Department of Pathology Medicine, Institute for Stem Cell Biology and Regenerative Medicine, Standford University School of Medicine,Palo Alto, California 94304, USA.

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http://dx.doi.org/10.1038/cr.2010.117DOI Listing
September 2010

Direct conversion of fibroblasts to functional neurons by defined factors.

Nature 2010 Feb 27;463(7284):1035-41. Epub 2010 Jan 27.

Institute for Stem Cell Biology and Regenerative Medicine, Department of Pathology, Stanford University School of Medicine, 1050 Arastradero Road, Palo Alto, California 94304, USA.

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http://dx.doi.org/10.1038/nature08797DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2829121PMC
February 2010

Functional characterization of cardiomyocytes derived from murine induced pluripotent stem cells in vitro.

FASEB J 2009 Dec 24;23(12):4168-80. Epub 2009 Aug 24.

Institute for Neurophysiology, Medical Center, University of Cologne, Cologne, Germany.

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http://dx.doi.org/10.1096/fj.08-128546DOI Listing
December 2009

Dissecting direct reprogramming through integrative genomic analysis.

Nature 2008 Jul 28;454(7200):49-55. Epub 2008 May 28.

Broad Institute of MIT and Harvard, 7 Cambridge Center, Cambridge, Massachusetts 02142, USA.

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http://dx.doi.org/10.1038/nature07056DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2754827PMC
July 2008

Sequential expression of pluripotency markers during direct reprogramming of mouse somatic cells.

Cell Stem Cell 2008 Feb;2(2):151-9

Whitehead Institute for Biomedical Research, Massachusetts Institute of Technology, 9 Cambridge Center, Cambridge, MA 02142, USA.

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http://dx.doi.org/10.1016/j.stem.2008.01.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2276627PMC
February 2008

c-Myc is dispensable for direct reprogramming of mouse fibroblasts.

Cell Stem Cell 2008 Jan 13;2(1):10-2. Epub 2007 Dec 13.

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http://dx.doi.org/10.1016/j.stem.2007.12.001DOI Listing
January 2008

Treatment of sickle cell anemia mouse model with iPS cells generated from autologous skin.

Science 2007 Dec 6;318(5858):1920-3. Epub 2007 Dec 6.

Whitehead Institute for Biomedical Research, Cambridge, MA 02142, USA.

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http://dx.doi.org/10.1126/science.1152092DOI Listing
December 2007

Direct reprogramming of genetically unmodified fibroblasts into pluripotent stem cells.

Nat Biotechnol 2007 Oct 27;25(10):1177-81. Epub 2007 Aug 27.

Whitehead Institute for Biomedical Research, Massachusetts Institute of Technology, Nine Cambridge Center, Cambridge Massachusetts 02142, USA.

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http://dx.doi.org/10.1038/nbt1335DOI Listing
October 2007

In vitro reprogramming of fibroblasts into a pluripotent ES-cell-like state.

Nature 2007 Jul 6;448(7151):318-24. Epub 2007 Jun 6.

Whitehead Institute for Biomedical Research, Massachusetts Institute of Technology, Cambridge, Massachusetts 02142, USA.

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http://dx.doi.org/10.1038/nature05944DOI Listing
July 2007

Functional integration of embryonic stem cell-derived neurons in vivo.

J Neurosci 2004 Jun;24(22):5258-68

Institute of Reconstructive Neurobiology, University of Bonn Medical Center and Hertie Foundation, University of Bonn, D-53105 Bonn, Germany.

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http://dx.doi.org/10.1523/JNEUROSCI.0428-04.200DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6729190PMC
June 2004

Migration and differentiation of myogenic precursors following transplantation into the developing rat brain.

Stem Cells 2003 ;21(2):181-9

Institute of Reconstructive Neurobiology, University of Bonn, Germany.

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http://dx.doi.org/10.1634/stemcells.21-2-181DOI Listing
September 2003

Functional integration of embryonic stem cell-derived neurons in hippocampal slice cultures.

J Neurosci 2003 Aug;23(18):7075-83

Institute of Reconstructive Neurobiology, University of Bonn Medical Center, D-53105 Bonn, Germany.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6740655PMC
August 2003

Tau EGFP embryonic stem cells: an efficient tool for neuronal lineage selection and transplantation.

J Neurosci Res 2002 Sep;69(6):918-24

Institute of Reconstructive Neurobiology and Department of Neuropathology, University of Bonn Medical Center, Bonn, Germany.

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http://dx.doi.org/10.1002/jnr.10395DOI Listing
September 2002

Fifty ways to make a neuron: shifts in stem cell hierarchy and their implications for neuropathology and CNS repair.

J Neuropathol Exp Neurol 2002 Feb;61(2):101-10

Department of Neuropathology, University of Bonn Medical Center, Germany.

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http://dx.doi.org/10.1093/jnen/61.2.101DOI Listing
February 2002