Marit J van Gils

Marit J van Gils

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Marit J van Gils

Marit J van Gils

Publications by authors named "Marit J van Gils"

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Autologous neutralizing antibody responses to an HIV envelope glycan hole are not easily broadened in rabbits.

J Virol 2020 Jan 15. Epub 2020 Jan 15.

Department of Integrative Structural and Computational Biology and the Skaggs Institute for Chemical Biology, The Scripps Research Institute, La Jolla, CA 92037, USA; Scripps Consortium for HIV/AIDS Vaccine Development (CHAVD), The Scripps Research Institute, La Jolla, CA 92037, USA; IAVI Neutralizing Antibody Center and the Collaboration for AIDS Vaccine Discovery (CAVD), The Scripps Research Institute, La Jolla, CA 92037, USA.

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http://dx.doi.org/10.1128/JVI.01861-19DOI Listing
January 2020

Antibody Responses Elicited by Immunization with BG505 Trimer Immune Complexes.

J Virol 2019 Oct 30;93(20). Epub 2019 Sep 30.

Department of Medicine, University of California Irvine, School of Medicine, Irvine, California, USA

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http://dx.doi.org/10.1128/JVI.01188-19DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6798112PMC
October 2019

The potential of engineered antibodies for HIV-1 therapy and cure.

Curr Opin Virol 2019 Oct 15;38:70-80. Epub 2019 Aug 15.

Department of Medical Microbiology, Amsterdam University Medical Centers, Location AMC, University of Amsterdam, Amsterdam, 1105 AZ, The Netherlands. Electronic address:

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http://dx.doi.org/10.1016/j.coviro.2019.07.007DOI Listing
October 2019

Similarities and differences between native HIV-1 envelope glycoprotein trimers and stabilized soluble trimer mimetics.

PLoS Pathog 2019 07 15;15(7):e1007920. Epub 2019 Jul 15.

Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, California, United States of America.

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http://dx.doi.org/10.1371/journal.ppat.1007920DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6658011PMC
July 2019

Conformational Plasticity in the HIV-1 Fusion Peptide Facilitates Recognition by Broadly Neutralizing Antibodies.

Cell Host Microbe 2019 06;25(6):873-883.e5

Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, CA 92037, USA; IAVI Neutralizing Antibody Center, The Scripps Research Institute, La Jolla, CA 92037, USA; Center for HIV/AIDS Vaccine Immunology and Immunogen Discovery, The Scripps Research Institute, La Jolla, CA 92037, USA; Skaggs Institute for Chemical Biology, The Scripps Research Institute, La Jolla, CA 92037, USA. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S19313128193021
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http://dx.doi.org/10.1016/j.chom.2019.04.011DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6579543PMC
June 2019

Lower Broadly Neutralizing Antibody Responses in Female Versus Male HIV-1 Infected Injecting Drug Users.

Viruses 2019 04 25;11(4). Epub 2019 Apr 25.

Department of Experimental Immunology, Amsterdam UMC, University of Amsterdam, 1105 AZ Amsterdam, The Netherlands.

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http://dx.doi.org/10.3390/v11040384DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6521154PMC
April 2019

HIV-1 immunogens and strategies to drive antibody responses towards neutralization breadth.

Retrovirology 2018 11 26;15(1):74. Epub 2018 Nov 26.

Department of Medical Microbiology, Amsterdam UMC, University of Amsterdam, Location AMC, Meibergdreef 9, Room K3-105, 1105AZ, Amsterdam, The Netherlands.

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http://dx.doi.org/10.1186/s12977-018-0457-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6260891PMC
November 2018

Short Communication: Protective Efficacy of Broadly Neutralizing Antibody PGDM1400 Against HIV-1 Challenge in Humanized Mice.

AIDS Res Hum Retroviruses 2018 09 22;34(9):790-793. Epub 2018 Aug 22.

1 Laboratory of Experimental Virology, Department of Medical Microbiology, Amsterdam UMC, University of Amsterdam , Amsterdam, the Netherlands .

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http://dx.doi.org/10.1089/AID.2018.0114DOI Listing
September 2018

Hitting HIV's Harpoon.

Immunity 2018 07;49(1):14-15

Department of Medical Microbiology, Amsterdam UMC, University of Amsterdam, 1105 AZ Amsterdam, the Netherlands; Department of Microbiology and Immunology, Weill Medical College of Cornell University, New York, NY 10021, USA. Electronic address:

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http://dx.doi.org/10.1016/j.immuni.2018.07.003DOI Listing
July 2018

The Neutralizing Antibody Response in an Individual with Triple HIV-1 Infection Remains Directed at the First Infecting Subtype.

AIDS Res Hum Retroviruses 2016 Oct/Nov;32(10-11):1135-1142. Epub 2016 Feb 24.

1 Laboratory of Experimental Virology, Department of Medical Microbiology, Center for Infection and Immunity Amsterdam (CINIMA), Academic Medical Center, University of Amsterdam , Amsterdam, the Netherlands .

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http://dx.doi.org/10.1089/aid.2015.0324DOI Listing
December 2017

Opposites attract in bispecific antibody engineering.

J Biol Chem 2017 09;292(35):14718-14719

From the Department of Medical Microbiology, Academic Medical Center, University of Amsterdam, 1105 AZ Amsterdam, The Netherlands and

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http://dx.doi.org/10.1074/jbc.H117.793497DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5582862PMC
September 2017

Natural infection as a blueprint for rational HIV vaccine design.

Hum Vaccin Immunother 2017 01 20;13(1):229-236. Epub 2016 Sep 20.

a Laboratory of Experimental Virology, Department of Medical Microbiology, Center for Infection and Immunity Amsterdam (CINIMA), Academic Medical Center, University of Amsterdam , Amsterdam , The Netherlands.

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http://dx.doi.org/10.1080/21645515.2016.1232785DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5287307PMC
January 2017

Direct Probing of Germinal Center Responses Reveals Immunological Features and Bottlenecks for Neutralizing Antibody Responses to HIV Env Trimer.

Cell Rep 2016 11;17(9):2195-2209

Division of Vaccine Discovery, La Jolla Institute for Allergy and Immunology, La Jolla, CA 92037, USA; Scripps Center for HIV/AIDS Vaccine Immunology and Immunogen Discovery, La Jolla, CA 92037, USA; Department of Medicine, Division of Infectious Diseases, University of California, San Diego, La Jolla, CA 92037, USA. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2016.10.085DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5142765PMC
November 2016

Probability of N332 glycan occupancy on HIV-1 gp120 modulates sensitivity to broadly neutralizing antibodies.

AIDS 2016 09;30(14):2179-84

aDepartment of Medical Microbiology bDepartment of Experimental Immunology, Academic Medical Center, University of Amsterdam, Amsterdam cJanssen Pharmaceuticals, Leiden, The Netherlands dDepartment of Microbiology and Immunology, Weill Medical College, Cornell University, New York City, New York, USA.

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http://dx.doi.org/10.1097/QAD.0000000000001177DOI Listing
September 2016

Holes in the Glycan Shield of the Native HIV Envelope Are a Target of Trimer-Elicited Neutralizing Antibodies.

Cell Rep 2016 08 18;16(9):2327-38. Epub 2016 Aug 18.

Department of Immunology & Microbial Science, IAVI Neutralizing Antibody Center, The Scripps Research Institute, La Jolla, CA 92037, USA; Center for HIV/AIDS Vaccine Immunology and Immunogen Discovery, The Scripps Research Institute, La Jolla, CA 92037, USA; Ragon Institute of Massachusetts General Hospital, Massachusetts Institute of Technology and Harvard University, Cambridge, MA 02139, USA. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2016.07.074DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5007210PMC
August 2016

Incomplete Neutralization and Deviation from Sigmoidal Neutralization Curves for HIV Broadly Neutralizing Monoclonal Antibodies.

PLoS Pathog 2015 Aug 12;11(8):e1005110. Epub 2015 Aug 12.

Department of Immunology and Microbial Science, International AIDS Vaccine Initiative Neutralizing Antibody Center and Center for HIV/AIDS Vaccine Immunology and Immunogen Discovery, The Scripps Research Institute, La Jolla, California, United States of America; Ragon Institute of Massachusetts General Hospital, Massachusetts Institute of Technology and Harvard University, Cambridge, Massachusetts, United States of America.

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http://dx.doi.org/10.1371/journal.ppat.1005110DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4534392PMC
August 2015

Recombinant HIV envelope trimer selects for quaternary-dependent antibodies targeting the trimer apex.

Proc Natl Acad Sci U S A 2014 Dec 24;111(49):17624-9. Epub 2014 Nov 24.

Department of Immunology and Microbial Science, International AIDS Vaccine Initiative Neutralizing Antibody Center, Center for HIV/AIDS Vaccine Immunology and Immunogen Discovery, Ragon Institute of Massachusetts General Hospital, Massachusetts Institute of Technology and Harvard University, Boston, MA 02142

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http://dx.doi.org/10.1073/pnas.1415789111DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4267403PMC
December 2014

In vivo protection by broadly neutralizing HIV antibodies.

Trends Microbiol 2014 Oct 26;22(10):550-1. Epub 2014 Aug 26.

Laboratory of Experimental Virology, Department of Medical Microbiology, Center for Infection and Immunity Amsterdam, Academic Medical Center, University of Amsterdam, The Netherlands; Department of Microbiology and Immunology, Weill Medical College of Cornell University, New York, NY 10021, USA. Electronic address:

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http://dx.doi.org/10.1016/j.tim.2014.08.006DOI Listing
October 2014

Early development of broadly reactive HIV-1 neutralizing activity in elite neutralizers.

AIDS 2014 May;28(8):1237-40

aDepartment of Experimental Immunology and Landsteiner Laboratory, Academic Medical Center, University of Amsterdam, Amsterdam bCrucell Holland BV, Leiden cDepartment of Medical Microbiology, Academic Medical Center, University of Amsterdam, Amsterdam, the Netherlands dDepartment of Microbiology and Immunology, Weill Medical College, Cornell University, New York, New York eRagon Institute of MGH, MIT and Harvard, Charlestown, Massachusetts, USA.

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http://dx.doi.org/10.1097/QAD.0000000000000228DOI Listing
May 2014

Broadly neutralizing HIV antibodies define a glycan-dependent epitope on the prefusion conformation of gp41 on cleaved envelope trimers.

Immunity 2014 May 24;40(5):657-68. Epub 2014 Apr 24.

Department of Immunology and Microbial Science, The Scripps Research Institute, La Jolla, CA 92037, USA; International AIDS Vaccine Initiative, Neutralizing Antibody Center, The Scripps Research Institute, La Jolla, CA 92037, USA; Center for HIV/AIDS Vaccine Immunology and Immunogen Discovery, The Scripps Research Institute, La Jolla, CA 92037, USA; Ragon Institute of Massachusetts General Hospital, Massachusetts Institute of Technology, and Harvard, Boston, MA 02114, USA. Electronic address:

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http://dx.doi.org/10.1016/j.immuni.2014.04.009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4070425PMC
May 2014

HIV-1 envelope glycoprotein signatures that correlate with the development of cross-reactive neutralizing activity.

Retrovirology 2013 Sep 23;10:102. Epub 2013 Sep 23.

Department of Medical Microbiology, Academic Medical Center, University of Amsterdam, 1105 AZ Amsterdam, the Netherlands.

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http://dx.doi.org/10.1186/1742-4690-10-102DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3849187PMC
September 2013

A next-generation cleaved, soluble HIV-1 Env trimer, BG505 SOSIP.664 gp140, expresses multiple epitopes for broadly neutralizing but not non-neutralizing antibodies.

PLoS Pathog 2013 Sep 19;9(9):e1003618. Epub 2013 Sep 19.

Department of Microbiology and Immunology, Weill Medical College of Cornell University, New York, New York, United States of America ; Department of Medical Microbiology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands.

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http://dx.doi.org/10.1371/journal.ppat.1003618DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3777863PMC
September 2013

Genome-wide association study on the development of cross-reactive neutralizing antibodies in HIV-1 infected individuals.

PLoS One 2013 23;8(1):e54684. Epub 2013 Jan 23.

Department Experimental Immunology, Sanquin Research, Landsteiner Laboratory, and Center for Infectious Diseases and Immunity Amsterdam, Academic Medical Center of the University of Amsterdam, Amsterdam, The Netherlands.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0054684PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3553002PMC
July 2013

Broadly neutralizing antibodies against HIV-1: templates for a vaccine.

Virology 2013 Jan;435(1):46-56

Laboratory of Experimental Virology, Department of Medical Microbiology, Center for Infection and Immunity Amsterdam, Academic Medical Center, University of Amsterdam, The Netherlands.

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https://linkinghub.elsevier.com/retrieve/pii/S00426822120050
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http://dx.doi.org/10.1016/j.virol.2012.10.004DOI Listing
January 2013

Longitudinal analysis of early HIV-1-specific neutralizing activity in an elite neutralizer and in five patients who developed cross-reactive neutralizing activity.

J Virol 2012 Feb 7;86(4):2045-55. Epub 2011 Dec 7.

Department of Experimental Immunology, Sanquin Research, Landsteiner Laboratory, Center for Infection and Immunity Amsterdam, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands.

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http://jvi.asm.org/content/early/2011/11/30/JVI.06091-11.ful
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http://jvi.asm.org/content/86/4/2045.full.pdf
Web Search
http://jvi.asm.org/cgi/doi/10.1128/JVI.06091-11
Publisher Site
http://dx.doi.org/10.1128/JVI.06091-11DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3302374PMC
February 2012

Evolution of human immunodeficiency virus type 1 in a patient with cross-reactive neutralizing activity in serum.

J Virol 2011 Aug 8;85(16):8443-8. Epub 2011 Jun 8.

Department of Experimental Immunology, Academic Medical Center, AZ Amsterdam, The Netherlands.

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http://dx.doi.org/10.1128/JVI.05214-11DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3147988PMC
August 2011

Correlations between HIV-1 clades and HIV-1 antibody neutralization sensitivity: significant for vaccine development?

Curr HIV Res 2010 Dec;8(8):579-86

Department Experimental Immunology, Academic Medical Center, Meibergdreef 9, Room M01-120, 1105 AZ Amsterdam, The Netherlands.

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http://dx.doi.org/10.2174/157016210794088254DOI Listing
December 2010

Genetic composition of replication competent clonal HIV-1 variants isolated from peripheral blood mononuclear cells (PBMC), HIV-1 proviral DNA from PBMC and HIV-1 RNA in serum in the course of HIV-1 infection.

Virology 2010 Sep 17;405(2):492-504. Epub 2010 Jul 17.

Department of Experimental Immunology, Sanquin Research, Landsteiner Laboratory, Department of Medical Microbiology, part of the Center for Infectious Diseases and Immunity Amsterdam (CINIMA) at the Academic Medical Center of the University of Amsterdam, Amsterdam, The Netherlands.

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http://dx.doi.org/10.1016/j.virol.2010.06.029DOI Listing
September 2010

Emergence of monoclonal antibody b12-resistant human immunodeficiency virus type 1 variants during natural infection in the absence of humoral or cellular immune pressure.

J Gen Virol 2010 May 6;91(Pt 5):1354-64. Epub 2010 Jan 6.

Department of Experimental Immunology, Sanquin Research, Landsteiner Laboratory and Center for Infection and Immunity Amsterdam (CINIMA), Academic Medical Center, University of Amsterdam, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands.

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http://dx.doi.org/10.1099/vir.0.017319-0DOI Listing
May 2010

Rapid escape from preserved cross-reactive neutralizing humoral immunity without loss of viral fitness in HIV-1-infected progressors and long-term nonprogressors.

J Virol 2010 Apr 13;84(7):3576-85. Epub 2010 Jan 13.

Department of Experimental Immunology, Academic Medical Center, M01-120, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands.

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http://dx.doi.org/10.1128/JVI.02622-09DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2838121PMC
April 2010

Cross-reactive neutralizing humoral immunity does not protect from HIV type 1 disease progression.

J Infect Dis 2010 Apr;201(7):1045-53

Department of Experimental Immunology, Landsteiner Laboratory Sanquin Research, and Center for Infection and Immunity, Academic Medical Center at the University of Amsterdam, 1105 AZ Amsterdam, The Netherlands.

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https://academic.oup.com/jid/article-lookup/doi/10.1086/6511
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http://dx.doi.org/10.1086/651144DOI Listing
April 2010

Prevalence of cross-reactive HIV-1-neutralizing activity in HIV-1-infected patients with rapid or slow disease progression.

AIDS 2009 Nov;23(18):2405-14

Department of Experimental Immunology, Landsteiner Laboratory Sanquin Research, and Center for Infection and Immunity (CINIMA), Academic Medical Center at the University of Amsterdam, Amsterdam, The Netherlands.

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http://dx.doi.org/10.1097/QAD.0b013e32833243e7DOI Listing
November 2009

Changing sensitivity to broadly neutralizing antibodies b12, 2G12, 2F5, and 4E10 of primary subtype B human immunodeficiency virus type 1 variants in the natural course of infection.

Virology 2009 Aug 17;390(2):348-55. Epub 2009 Jun 17.

Department of Experimental Immunology, Sanquin Research, Landsteiner Laboratory and Center for Infection and Immunity Amsterdam (CINIMA), Academic Medical Center, University of Amsterdam, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands.

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http://dx.doi.org/10.1016/j.virol.2009.05.028DOI Listing
August 2009