Publications by authors named "Marisa Freitas"

81Publications

Flavonoids as potential agents in the management of type 2 diabetes through the modulation of α-amylase and α-glucosidase activity: a review.

Crit Rev Food Sci Nutr 2021 Jan 11:1-71. Epub 2021 Jan 11.

LAQV, REQUIMTE, Laboratory of Applied Chemistry, Department of Chemical Sciences, Faculty of Pharmacy, University of Porto, Porto, Portugal.

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January 2021

Chalcones as Modulators of Neutrophil Oxidative Burst under Physiological and High Glucose Conditions.

J Nat Prod 2020 10 2;83(10):3131-3140. Epub 2020 Oct 2.

LAQV, REQUIMTE, Laboratory of Applied Chemistry, Department of Chemical Sciences, Faculty of Pharmacy, University of Porto, Porto 4050-313, Portugal.

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October 2020

OMICs Approaches in Diarrhetic Shellfish Toxins Research.

Toxins (Basel) 2020 07 31;12(8). Epub 2020 Jul 31.

IPMA-Instituto Português do Mar da Atmosfera, Rua Alfredo Magalhães Ramalho, 6, 1495-006 Lisbon, Portugal.

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July 2020

The effect of chalcones on the main sources of reactive species production: possible therapeutic implications in diabetes mellitus.

Curr Med Chem 2020 May 24. Epub 2020 May 24.

LAQV, REQUIMTE, Laboratory of Applied Chemistry, Department of Chemical, Sciences, Faculty of Pharmacy, University of Porto, 4050-313 Porto. Portugal.

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May 2020

Structural Specificity of Flavonoids in the Inhibition of Human Fructose 1,6-Bisphosphatase.

J Nat Prod 2020 05 4;83(5):1541-1552. Epub 2020 May 4.

LAQV, REQUIMTE, Laboratory of Applied Chemistry, Department of Chemical Sciences, Faculty of Pharmacy, University of Porto, 4050-313 Porto, Portugal.

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May 2020

β-Carotene and its physiological metabolites: Effects on oxidative status regulation and genotoxicity in in vitro models.

Food Chem Toxicol 2020 Jul 28;141:111392. Epub 2020 Apr 28.

LAQV, REQUIMTE, Laboratory of Applied Chemistry, Department of Chemical Sciences, Faculty of Pharmacy, University of Porto, Porto, Portugal. Electronic address:

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July 2020

Analysis of the Use of Cylindrospermopsin and/or Microcystin-Contaminated Water in the Growth, Mineral Content, and Contamination of and .

Toxins (Basel) 2019 10 28;11(11). Epub 2019 Oct 28.

CIIMAR/CIMAR, Interdisciplinary Centre of Marine and Environmental Research, University of Porto, Terminal de Cruzeiros do Porto de Leixões, Av. General Norton de Matos, s/n, 4450-208 Porto, Portugal.

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October 2019

Global, Regional, and National Cancer Incidence, Mortality, Years of Life Lost, Years Lived With Disability, and Disability-Adjusted Life-Years for 29 Cancer Groups, 1990 to 2017: A Systematic Analysis for the Global Burden of Disease Study.

Authors:
Christina Fitzmaurice Degu Abate Naghmeh Abbasi Hedayat Abbastabar Foad Abd-Allah Omar Abdel-Rahman Ahmed Abdelalim Amir Abdoli Ibrahim Abdollahpour Abdishakur S M Abdulle Nebiyu Dereje Abebe Haftom Niguse Abraha Laith Jamal Abu-Raddad Ahmed Abualhasan Isaac Akinkunmi Adedeji Shailesh M Advani Mohsen Afarideh Mahdi Afshari Mohammad Aghaali Dominic Agius Sutapa Agrawal Ayat Ahmadi Elham Ahmadian Ehsan Ahmadpour Muktar Beshir Ahmed Mohammad Esmaeil Akbari Tomi Akinyemiju Ziyad Al-Aly Assim M AlAbdulKader Fares Alahdab Tahiya Alam Genet Melak Alamene Birhan Tamene T Alemnew Kefyalew Addis Alene Cyrus Alinia Vahid Alipour Syed Mohamed Aljunid Fatemeh Allah Bakeshei Majid Abdulrahman Hamad Almadi Amir Almasi-Hashiani Ubai Alsharif Shirina Alsowaidi Nelson Alvis-Guzman Erfan Amini Saeed Amini Yaw Ampem Amoako Zohreh Anbari Nahla Hamed Anber Catalina Liliana Andrei Mina Anjomshoa Fereshteh Ansari Ansariadi Ansariadi Seth Christopher Yaw Appiah Morteza Arab-Zozani Jalal Arabloo Zohreh Arefi Olatunde Aremu Habtamu Abera Areri Al Artaman Hamid Asayesh Ephrem Tsegay Asfaw Alebachew Fasil Ashagre Reza Assadi Bahar Ataeinia Hagos Tasew Atalay Zerihun Ataro Suleman Atique Marcel Ausloos Leticia Avila-Burgos Euripide F G A Avokpaho Ashish Awasthi Nefsu Awoke Beatriz Paulina Ayala Quintanilla Martin Amogre Ayanore Henok Tadesse Ayele Ebrahim Babaee Umar Bacha Alaa Badawi Mojtaba Bagherzadeh Eleni Bagli Senthilkumar Balakrishnan Abbas Balouchi Till Winfried Bärnighausen Robert J Battista Masoud Behzadifar Meysam Behzadifar Bayu Begashaw Bekele Yared Belete Belay Yaschilal Muche Belayneh Kathleen Kim Sachiko Berfield Adugnaw Berhane Eduardo Bernabe Mircea Beuran Nickhill Bhakta Krittika Bhattacharyya Belete Biadgo Ali Bijani Muhammad Shahdaat Bin Sayeed Charles Birungi Catherine Bisignano Helen Bitew Tone Bjørge Archie Bleyer Kassawmar Angaw Bogale Hunduma Amensisa Bojia Antonio M Borzì Cristina Bosetti Ibrahim R Bou-Orm Hermann Brenner Jerry D Brewer Andrey Nikolaevich Briko Nikolay Ivanovich Briko Maria Teresa Bustamante-Teixeira Zahid A Butt Giulia Carreras Juan J Carrero Félix Carvalho Clara Castro Franz Castro Ferrán Catalá-López Ester Cerin Yazan Chaiah Wagaye Fentahun Chanie Vijay Kumar Chattu Pankaj Chaturvedi Neelima Singh Chauhan Mohammad Chehrazi Peggy Pei-Chia Chiang Tesfaye Yitna Chichiabellu Onyema Greg Chido-Amajuoyi Odgerel Chimed-Ochir Jee-Young J Choi Devasahayam J Christopher Dinh-Toi Chu Maria-Magdalena Constantin Vera M Costa Emanuele Crocetti Christopher Stephen Crowe Maria Paula Curado Saad M A Dahlawi Giovanni Damiani Amira Hamed Darwish Ahmad Daryani José das Neves Feleke Mekonnen Demeke Asmamaw Bizuneh Demis Birhanu Wondimeneh Demissie Gebre Teklemariam Demoz Edgar Denova-Gutiérrez Afshin Derakhshani Kalkidan Solomon Deribe Rupak Desai Beruk Berhanu Desalegn Melaku Desta Subhojit Dey Samath Dhamminda Dharmaratne Meghnath Dhimal Daniel Diaz Mesfin Tadese Tadese Dinberu Shirin Djalalinia David Teye Doku Thomas M Drake Manisha Dubey Eleonora Dubljanin Eyasu Ejeta Duken Hedyeh Ebrahimi Andem Effiong Aziz Eftekhari Iman El Sayed Maysaa El Sayed Zaki Shaimaa I El-Jaafary Ziad El-Khatib Demelash Abewa Elemineh Hajer Elkout Richard G Ellenbogen Aisha Elsharkawy Mohammad Hassan Emamian Daniel Adane Endalew Aman Yesuf Endries Babak Eshrati Ibtihal Fadhil Vahid Fallah Omrani Mahbobeh Faramarzi Mahdieh Abbasalizad Farhangi Andrea Farioli Farshad Farzadfar Netsanet Fentahun Eduarda Fernandes Garumma Tolu Feyissa Irina Filip Florian Fischer James L Fisher Lisa M Force Masoud Foroutan Marisa Freitas Takeshi Fukumoto Neal D Futran Silvano Gallus Fortune Gbetoho Gankpe Reta Tsegaye Gayesa Tsegaye Tewelde Gebrehiwot Gebreamlak Gebremedhn Gebremeskel Getnet Azeze Gedefaw Belayneh K Gelaw Birhanu Geta Sefonias Getachew Kebede Embaye Gezae Mansour Ghafourifard Alireza Ghajar Ahmad Ghashghaee Asadollah Gholamian Paramjit Singh Gill Themba T G Ginindza Alem Girmay Muluken Gizaw Ricardo Santiago Gomez Sameer Vali Gopalani Giuseppe Gorini Bárbara Niegia Garcia Goulart Ayman Grada Maximiliano Ribeiro Guerra Andre Luiz Sena Guimaraes Prakash C Gupta Rahul Gupta Kishor Hadkhale Arvin Haj-Mirzaian Arya Haj-Mirzaian Randah R Hamadeh Samer Hamidi Lolemo Kelbiso Hanfore Josep Maria Haro Milad Hasankhani Amir Hasanzadeh Hamid Yimam Hassen Roderick J Hay Simon I Hay Andualem Henok Nathaniel J Henry Claudiu Herteliu Hagos D Hidru Chi Linh Hoang Michael K Hole Praveen Hoogar Nobuyuki Horita H Dean Hosgood Mostafa Hosseini Mehdi Hosseinzadeh Mihaela Hostiuc Sorin Hostiuc Mowafa Househ Mohammedaman Mama Hussen Bogdan Ileanu Milena D Ilic Kaire Innos Seyed Sina Naghibi Irvani Kufre Robert Iseh Sheikh Mohammed Shariful Islam Farhad Islami Nader Jafari Balalami Morteza Jafarinia Leila Jahangiry Mohammad Ali Jahani Nader Jahanmehr Mihajlo Jakovljevic Spencer L James Mehdi Javanbakht Sudha Jayaraman Sun Ha Jee Ensiyeh Jenabi Ravi Prakash Jha Jost B Jonas Jitendra Jonnagaddala Tamas Joo Suresh Banayya Jungari Mikk Jürisson Ali Kabir Farin Kamangar André Karch Narges Karimi Ansar Karimian Amir Kasaeian Gebremicheal Gebreslassie Kasahun Belete Kassa Tesfaye Dessale Kassa Mesfin Wudu Kassaw Anil Kaul Peter Njenga Keiyoro Abraham Getachew Kelbore Amene Abebe Kerbo Yousef Saleh Khader Maryam Khalilarjmandi Ejaz Ahmad Khan Gulfaraz Khan Young-Ho Khang Khaled Khatab Amir Khater Maryam Khayamzadeh Maryam Khazaee-Pool Salman Khazaei Abdullah T Khoja Mohammad Hossein Khosravi Jagdish Khubchandani Neda Kianipour Daniel Kim Yun Jin Kim Adnan Kisa Sezer Kisa Katarzyna Kissimova-Skarbek Hamidreza Komaki Ai Koyanagi Kristopher J Krohn Burcu Kucuk Bicer Nuworza Kugbey Vivek Kumar Desmond Kuupiel Carlo La Vecchia Deepesh P Lad Eyasu Alem Lake Ayenew Molla Lakew Dharmesh Kumar Lal Faris Hasan Lami Qing Lan Savita Lasrado Paolo Lauriola Jeffrey V Lazarus James Leigh Cheru Tesema Leshargie Yu Liao Miteku Andualem Limenih Stefan Listl Alan D Lopez Platon D Lopukhov Raimundas Lunevicius Mohammed Madadin Sameh Magdeldin Hassan Magdy Abd El Razek Azeem Majeed Afshin Maleki Reza Malekzadeh Ali Manafi Navid Manafi Wondimu Ayele Manamo Morteza Mansourian Mohammad Ali Mansournia Lorenzo Giovanni Mantovani Saman Maroufizadeh Santi Martini S Martini Tivani Phosa Mashamba-Thompson Benjamin Ballard Massenburg Motswadi Titus Maswabi Manu Raj Mathur Colm McAlinden Martin McKee Hailemariam Abiy Alemu Meheretu Ravi Mehrotra Varshil Mehta Toni Meier Yohannes A Melaku Gebrekiros Gebremichael Meles Hagazi Gebre Meles Addisu Melese Mulugeta Melku Peter T N Memiah Walter Mendoza Ritesh G Menezes Shahin Merat Tuomo J Meretoja Tomislav Mestrovic Bartosz Miazgowski Tomasz Miazgowski Kebadnew Mulatu M Mihretie Ted R Miller Edward J Mills Seyed Mostafa Mir Hamed Mirzaei Hamid Reza Mirzaei Rashmi Mishra Babak Moazen Dara K Mohammad Karzan Abdulmuhsin Mohammad Yousef Mohammad Aso Mohammad Darwesh Abolfazl Mohammadbeigi Hiwa Mohammadi Moslem Mohammadi Mahdi Mohammadian Abdollah Mohammadian-Hafshejani Milad Mohammadoo-Khorasani Reza Mohammadpourhodki Ammas Siraj Mohammed Jemal Abdu Mohammed Shafiu Mohammed Farnam Mohebi Ali H Mokdad Lorenzo Monasta Yoshan Moodley Mahmood Moosazadeh Maryam Moossavi Ghobad Moradi Mohammad Moradi-Joo Maziar Moradi-Lakeh Farhad Moradpour Lidia Morawska Joana Morgado-da-Costa Naho Morisaki Shane Douglas Morrison Abbas Mosapour Seyyed Meysam Mousavi Achenef Asmamaw Muche Oumer Sada S Muhammed Jonah Musa Ashraf F Nabhan Mehdi Naderi Ahamarshan Jayaraman Nagarajan Gabriele Nagel Azin Nahvijou Gurudatta Naik Farid Najafi Luigi Naldi Hae Sung Nam Naser Nasiri Javad Nazari Ionut Negoi Subas Neupane Polly A Newcomb Haruna Asura Nggada Josephine W Ngunjiri Cuong Tat Nguyen Leila Nikniaz Dina Nur Anggraini Ningrum Yirga Legesse Nirayo Molly R Nixon Chukwudi A Nnaji Marzieh Nojomi Shirin Nosratnejad Malihe Nourollahpour Shiadeh Mohammed Suleiman Obsa Richard Ofori-Asenso Felix Akpojene Ogbo In-Hwan Oh Andrew T Olagunju Tinuke O Olagunju Mojisola Morenike Oluwasanu Abidemi E Omonisi Obinna E Onwujekwe Anu Mary Oommen Eyal Oren Doris D V Ortega-Altamirano Erika Ota Stanislav S Otstavnov Mayowa Ojo Owolabi Mahesh P A Jagadish Rao Padubidri Smita Pakhale Amir H Pakpour Adrian Pana Eun-Kee Park Hadi Parsian Tahereh Pashaei Shanti Patel Snehal T Patil Alyssa Pennini David M Pereira Cristiano Piccinelli Julian David Pillay Majid Pirestani Farhad Pishgar Maarten J Postma Hadi Pourjafar Farshad Pourmalek Akram Pourshams Swayam Prakash Narayan Prasad Mostafa Qorbani Mohammad Rabiee Navid Rabiee Amir Radfar Alireza Rafiei Fakher Rahim Mahdi Rahimi Muhammad Aziz Rahman Fatemeh Rajati Saleem M Rana Samira Raoofi Goura Kishor Rath David Laith Rawaf Salman Rawaf Robert C Reiner Andre M N Renzaho Nima Rezaei Aziz Rezapour Ana Isabel Ribeiro Daniela Ribeiro Luca Ronfani Elias Merdassa Roro Gholamreza Roshandel Ali Rostami Ragy Safwat Saad Parisa Sabbagh Siamak Sabour Basema Saddik Saeid Safiri Amirhossein Sahebkar Mohammad Reza Salahshoor Farkhonde Salehi Hosni Salem Marwa Rashad Salem Hamideh Salimzadeh Joshua A Salomon Abdallah M Samy Juan Sanabria Milena M Santric Milicevic Benn Sartorius Arash Sarveazad Brijesh Sathian Maheswar Satpathy Miloje Savic Monika Sawhney Mehdi Sayyah Ione J C Schneider Ben Schöttker Mario Sekerija Sadaf G Sepanlou Masood Sepehrimanesh Seyedmojtaba Seyedmousavi Faramarz Shaahmadi Hosein Shabaninejad Mohammad Shahbaz Masood Ali Shaikh Amir Shamshirian Morteza Shamsizadeh Heidar Sharafi Zeinab Sharafi Mehdi Sharif Ali Sharifi Hamid Sharifi Rajesh Sharma Aziz Sheikh Reza Shirkoohi Sharvari Rahul Shukla Si Si Soraya Siabani Diego Augusto Santos Silva Dayane Gabriele Alves Silveira Ambrish Singh Jasvinder A Singh Solomon Sisay Freddy Sitas Eugène Sobngwi Moslem Soofi Joan B Soriano Vasiliki Stathopoulou Mu'awiyyah Babale Sufiyan Rafael Tabarés-Seisdedos Takahiro Tabuchi Ken Takahashi Omid Reza Tamtaji Mohammed Rasoul Tarawneh Segen Gebremeskel Tassew Parvaneh Taymoori Arash Tehrani-Banihashemi Mohamad-Hani Temsah Omar Temsah Berhe Etsay Tesfay Fisaha Haile Tesfay Manaye Yihune Teshale Gizachew Assefa Tessema Subash Thapa Kenean Getaneh Tlaye Roman Topor-Madry Marcos Roberto Tovani-Palone Eugenio Traini Bach Xuan Tran Khanh Bao Tran Afewerki Gebremeskel Tsadik Irfan Ullah Olalekan A Uthman Marco Vacante Maryam Vaezi Patricia Varona Pérez Yousef Veisani Simone Vidale Francesco S Violante Vasily Vlassov Stein Emil Vollset Theo Vos Kia Vosoughi Giang Thu Vu Isidora S Vujcic Henry Wabinga Tesfahun Mulatu Wachamo Fasil Shiferaw Wagnew Yasir Waheed Fitsum Weldegebreal Girmay Teklay Weldesamuel Tissa Wijeratne Dawit Zewdu Wondafrash Tewodros Eshete Wonde Adam Belay Wondmieneh Hailemariam Mekonnen Workie Rajaram Yadav Abbas Yadegar Ali Yadollahpour Mehdi Yaseri Vahid Yazdi-Feyzabadi Alex Yeshaneh Mohammed Ahmed Yimam Ebrahim M Yimer Engida Yisma Naohiro Yonemoto Mustafa Z Younis Bahman Yousefi Mahmoud Yousefifard Chuanhua Yu Erfan Zabeh Vesna Zadnik Telma Zahirian Moghadam Zoubida Zaidi Mohammad Zamani Hamed Zandian Alireza Zangeneh Leila Zaki Kazem Zendehdel Zerihun Menlkalew Zenebe Taye Abuhay Zewale Arash Ziapour Sanjay Zodpey Christopher J L Murray

JAMA Oncol 2019 12;5(12):1749-1768

Institute for Health Metrics and Evaluation, University of Washington, Seattle.

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December 2019

The dipeptidyl peptidase-4 inhibitory effect of flavonoids is hindered in protein rich environments.

Food Funct 2019 Sep 23;10(9):5718-5731. Epub 2019 Aug 23.

LAQV, REQUIMTE, Laboratory of Applied Chemistry, Department of Chemical Sciences, Faculty of Pharmacy, University of Porto, 4050-313 Porto, Portugal.

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September 2019

Anti-inflammatory Effects of Persimmon ( L.) in Experimental Rodent Rheumatoid Arthritis.

J Diet Suppl 2020 30;17(6):663-683. Epub 2019 Jul 30.

Faculty of Pharmacy (FFULisboa) and Research Institute for Medicines and Pharmaceutical Sciences (iMed.ULisboa), University of Lisbon, Lisboa, Portugal.

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July 2019

Optimization of Experimental Settings for the Assessment of Reactive Oxygen Species Production by Human Blood.

Oxid Med Cell Longev 2019 10;2019:7198484. Epub 2019 Jan 10.

LAQV, REQUIMTE, Laboratory of Applied Chemistry, Department of Chemical Sciences, Faculty of Pharmacy, University of Porto, 4050-313 Porto, Portugal.

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March 2019

Evaluation of a flavonoids library for inhibition of pancreatic α-amylase towards a structure-activity relationship.

J Enzyme Inhib Med Chem 2019 Dec;34(1):577-588

a LAQV, REQUIMTE, Laboratory of Applied Chemistry, Department of Chemical Sciences, Faculty of Pharmacy , University of Porto , Porto , Portugal.

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December 2019

Calcium Pathways in Human Neutrophils-The Extended Effects of Thapsigargin and ML-9.

Cells 2018 Nov 9;7(11). Epub 2018 Nov 9.

LAQV, REQUIMTE, Laboratory of Applied Chemistry, Department of Chemical Sciences, Faculty of Pharmacy, University of Porto, 4050-313 Porto, Portugal.

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November 2018

A comprehensive review on xanthone derivatives as α-glucosidase inhibitors.

Eur J Med Chem 2018 Sep 7;157:1460-1479. Epub 2018 Aug 7.

LAQV, REQUIMTE, Laboratory of Applied Chemistry, Department of Chemical Sciences, Faculty of Pharmacy, University of Porto, 4050-313, Porto, Portugal. Electronic address:

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September 2018

A Systematic Review on Anti-diabetic Properties of Chalcones.

Curr Med Chem 2020 ;27(14):2257-2321

LAQV, REQUIMTE, Laboratory of Applied Chemistry, Department of Chemical Sciences, Faculty of Pharmacy, University of Porto, Rua de Jorge Viterbo Ferreira No. 228, 4050-313 Porto, Portugal.

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July 2020

Antioxidant and pro-oxidant activities of carotenoids and their oxidation products.

Food Chem Toxicol 2018 Oct 2;120:681-699. Epub 2018 Aug 2.

LAQV, REQUIMTE, Laboratory of Applied Chemistry, Department of Chemical Sciences, Faculty of Pharmacy, University of Porto, Porto, Portugal. Electronic address:

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October 2018

Immunomodulatory Effects of Flavonoids in the Prophylaxis and Treatment of Inflammatory Bowel Diseases: A Comprehensive Review.

Curr Med Chem 2018 ;25(28):3374-3412

LAQV, REQUIMTE, Laboratory of Applied Chemistry, Department of Chemical Sciences, Faculty of Pharmacy, University of Porto, Porto, Portugal.

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September 2018

Inhibition of protein tyrosine phosphatase 1B by flavonoids: A structure - activity relationship study.

Food Chem Toxicol 2018 Jan 22;111:474-481. Epub 2017 Nov 22.

UCIBIO, REQUIMTE, Laboratory of Applied Chemistry, Department of Chemical Sciences, Faculty of Pharmacy, University of Porto, 4050-313 Porto, Portugal. Electronic address:

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January 2018

α-Glucosidase inhibition by flavonoids: an in vitro and in silico structure-activity relationship study.

J Enzyme Inhib Med Chem 2017 Dec;32(1):1216-1228

a UCIBIO, REQUIMTE, Laboratory of Applied Chemistry, Department of Chemical Sciences, Faculty of Pharmacy , University of Porto , Porto , Portugal.

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December 2017

Chlorinated Flavonoids Modulate the Inflammatory Process in Human Blood.

Inflammation 2017 Aug;40(4):1155-1165

UCIBIO, REQUIMTE, Laboratory of Applied Chemistry, Department of Chemical Sciences, Faculty of Pharmacy, University of Porto, Rua de Jorge Viterbo Ferreira no. 228, 4050-313, Porto, Portugal.

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August 2017

Chemical characterization and protective effect of the Bactris setosa Mart. fruit against oxidative/nitrosative stress.

Food Chem 2017 Apr 30;220:427-437. Epub 2016 Sep 30.

UCIBIO, REQUIMTE, Laboratory of Applied Chemistry, Department of Chemical Sciences, Faculty of Pharmacy, University of Porto, 4050-313 Porto, Portugal. Electronic address:

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April 2017

Algae Polysaccharides' Chemical Characterization and their Role in the Inflammatory Process.

Curr Med Chem 2017 ;24(2):149-175

UCIBIO, REQUIMTE, Laboratory of Applied Chemistry, Department of Chemical Sciences, Faculty of Pharmacy, University of Porto, Porto, Portugal.

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July 2017

Protective effects of a blueberry extract in acute inflammation and collagen-induced arthritis in the rat.

Biomed Pharmacother 2016 Oct 20;83:1191-1202. Epub 2016 Aug 20.

iMED.ULisboa and Faculdade de Farmácia - Universidade de Lisboa, Avenida Prof. Gama Pinto, 1649-003 Lisboa, Portugal. Electronic address:

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October 2016

Ochratoxin A activates neutrophils and kills these cells through necrosis, an effect eliminated through its conversion into ochratoxin α.

Toxicology 2016 Aug 3;368-369:91-102. Epub 2016 Sep 3.

UCIBIO, REQUIMTE, Laboratório de Química Aplicada, Departamento de Ciências Químicas, Faculdade de Farmácia, Universidade do Porto, 4050-313 Porto, Portugal. Electronic address:

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August 2016

Combined dual effect of modulation of human neutrophils' oxidative burst and inhibition of colon cancer cells proliferation by hydroxycinnamic acid derivatives.

Bioorg Med Chem 2016 08 30;24(16):3556-64. Epub 2016 May 30.

Pharmaceutical Chemistry Group, Faculty of Pharmacy, University of Coimbra, Azinhaga de Santa Comba, 3000-548 Coimbra, Portugal; CNC.IBILI, University of Coimbra, Portugal. Electronic address:

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August 2016

New polyhydroxylated flavon-3-ols and 3-hydroxy-2-styrylchromones: synthesis and ROS/RNS scavenging activities.

Eur J Med Chem 2016 Aug 25;119:250-9. Epub 2016 Apr 25.

QOPNA, Department of Chemistry, University of Aveiro, 3810-193 Aveiro, Portugal. Electronic address:

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August 2016

Biodistribution of polyacrylic acid-coated iron oxide nanoparticles is associated with proinflammatory activation and liver toxicity.

J Appl Toxicol 2016 10 22;36(10):1321-31. Epub 2016 Apr 22.

UCIBIO-REQUIMTE, Laboratory of Applied Chemistry, Department of Chemical Sciences, Faculty of Pharmacy, University of Porto, Porto, Portugal.

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October 2016

Novel chromone and xanthone derivatives: Synthesis and ROS/RNS scavenging activities.

Eur J Med Chem 2016 Jun 21;115:381-92. Epub 2016 Mar 21.

UCIBIO-REQUIMTE, Applied Chemistry Laboratory, Department of Chemical Sciences, Faculty of Pharmacy, University of Porto, Rua de Jorge Viterbo Ferreira, 228, 4050-313 Porto, Portugal. Electronic address:

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June 2016

Size-dependent cytotoxicity of silver nanoparticles in human neutrophils assessed by multiple analytical approaches.

Life Sci 2016 Jan 29;145:247-54. Epub 2015 Dec 29.

UCIBIO-REQUIMTE, Departamento de Ciências Químicas, Faculdade de Farmácia, Universidade do Porto, 4050-313 Porto, Portugal. Electronic address:

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January 2016

Uncovering novel 3-hydroxy-4-pyridinone metal ion complexes with potential anti-inflammatory properties.

J Inorg Biochem 2016 Feb 11;155:9-16. Epub 2015 Nov 11.

UCIBIO, REQUIMTE, Department of Chemical Sciences, Faculty of Pharmacy, University of Porto (FFUP), 4050-313 Porto, Portugal. Electronic address:

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February 2016

Superoxide Anion Radical: Generation and Detection in Cellular and Non-Cellular Systems.

Curr Med Chem 2015 ;22(37):4234-56

UCIBIOREQUIMTE, Department of Chemical Sciences, Faculty of Pharmacy, University of Porto. Rua de Jorge Viterbo Ferreira, 228, 4050-313 Porto, Portugal.

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July 2016

Flavonoids inhibit the production of cytokines/chemokines and induce apoptosis in human neutrophils.

Free Radic Biol Med 2014 Oct 10;75 Suppl 1:S46. Epub 2014 Dec 10.

Faculdade de Farmácia, Universidade do Porto (REQUIMTE), Departamento de Ciências Químicas, Portugal.

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October 2014

Anti-inflammatory and pro-apoptotic activities of chlorinated flavonoids in human neutrophils.

Free Radic Biol Med 2014 Oct 10;75 Suppl 1:S30. Epub 2014 Dec 10.

REQUIMTE (Departamento de Ciências Químicas), Faculdade de Farmácia, Universidade do Porto, Portugal.

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October 2014

Vismia cauliflora extracts: bioactive compounds and the in vitro scavenging capacity against reactive oxygen and nitrogen species.

Free Radic Biol Med 2014 Oct 10;75 Suppl 1:S26. Epub 2014 Dec 10.

REQUIMTE, University of Porto (Faculty of Pharmacy), Department of Chemical Sciences, Portugal.

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October 2014

Proinflammatory Pathways: The Modulation by Flavonoids.

Med Res Rev 2015 Sep 30;35(5):877-936. Epub 2015 Apr 30.

UCIBIO-REQUIMTE, Departamento de Ciências Químicas, Faculdade de Farmácia, Universidade do Porto, 4050-313, Porto, Portugal.

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September 2015

Effects of microcystin-LR, cylindrospermopsin and a microcystin-LR/cylindrospermopsin mixture on growth, oxidative stress and mineral content in lettuce plants (Lactuca sativa L.).

Ecotoxicol Environ Saf 2015 Jun 10;116:59-67. Epub 2015 Mar 10.

CIIMAR/CIMAR-Interdisciplinary Centre of Marine and Environmental Research, University of Porto, Rua dos Bragas 289, P 4050-123 Porto, Portugal; Faculty of Sciences, Porto University, Rua do Campo Alegre, 4169-007 Porto, Portugal.

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June 2015

Iron Oxide Nanoparticles: An Insight into their Biomedical Applications

Curr Med Chem 2015 05;22(15):1808 - 28

UCIBIO-REQUIMTE, Laboratory of Applied Chemistry Department of Chemical Sciences Faculty of Pharmacy, University of Porto, Porto, Portugal Rua de Jorge Viterbo Ferreira n. º 228, 4050-313 Porto, Portugal.

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May 2015

Inhibition of NF-kB activation and cytokines production in THP-1 monocytes by 2-styrylchromones.

Med Chem 2015 ;11(6):560-6

UCIBIO-REQUIMTE, Departamento de Ciências Químicas, Faculdade de Farmácia, Universidade do Porto, Rua Jorge Viterbo Ferreira nº 228, 4050-313 Porto, Portugal.

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May 2016

Lettuce (Lactuca sativa L.) leaf-proteome profiles after exposure to cylindrospermopsin and a microcystin-LR/cylindrospermopsin mixture: a concentration-dependent response.

Phytochemistry 2015 Feb 29;110:91-103. Epub 2014 Dec 29.

CIIMAR/CIMAR - Interdisciplinary Centre of Marine and Environmental Research, University of Porto, Rua dos Bragas 289, P 4050-123 Porto, Portugal; Faculty of Sciences, Porto University, Rua do Campo Alegre, 4169-007 Porto, Portugal. Electronic address:

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February 2015

Inhibition of glycogen synthase kinase-3β attenuates organ injury and dysfunction associated with liver ischemia-reperfusion and thermal injury in the rat.

Shock 2015 Apr;43(4):369-78

*Research Institute for Medicines (iMed.ULisboa), Faculdade de Farmácia, Universidade de Lisboa, Lisboa; and †REQUIMTE, Laboratório de Química Aplicada, Departamento de Ciências Químicas, Faculdade de Farmácia, Universidade do Porto, Porto, Portugal.

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April 2015

Synthesis of chlorinated flavonoids with anti-inflammatory and pro-apoptotic activities in human neutrophils.

Eur J Med Chem 2014 Oct 14;86:153-64. Epub 2014 Aug 14.

REQUIMTE, Departamento de Ciências Químicas, Faculdade de Farmácia, Universidade do Porto, 4050-313 Porto, Portugal. Electronic address:

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October 2014

Carotenoids are effective inhibitors of in vitro hemolysis of human erythrocytes, as determined by a practical and optimized cellular antioxidant assay.

J Food Sci 2014 Sep 20;79(9):H1841-7. Epub 2014 Aug 20.

Dept. of Food Science, Faculty of Food Engineering, Univ. of Campinas (UNICAMP), Campinas, SP, 13083-862, Brazil; REQUIMTE, Dept. of Chemical Sciences, Faculty of Pharmacy, Univ. of Porto (FFUP), Porto, 4050-313, Portugal.

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September 2014

Flavonoids inhibit COX-1 and COX-2 enzymes and cytokine/chemokine production in human whole blood.

Inflammation 2015 Apr;38(2):858-70

REQUIMTE, Departamento de Ciências Químicas, Faculdade de Farmácia, Universidade do Porto, Rua Jorge Viterbo Ferreira n 228, 4050-313, Porto, Portugal.

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April 2015

Polyacrylic acid-coated and non-coated iron oxide nanoparticles induce cytokine activation in human blood cells through TAK1, p38 MAPK and JNK pro-inflammatory pathways.

Arch Toxicol 2015 Oct 10;89(10):1759-69. Epub 2014 Aug 10.

REQUIMTE, Laboratory of Applied Chemistry, Department of Chemical Sciences, Faculty of Pharmacy, University of Porto, Porto, Portugal.

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October 2015

Psidium cattleianum fruit extracts are efficient in vitro scavengers of physiologically relevant reactive oxygen and nitrogen species.

Food Chem 2014 Dec 22;165:140-8. Epub 2014 May 22.

REQUIMTE, Department of Chemical Sciences, Faculty of Pharmacy, University of Porto, 4050-313 Porto, Portugal. Electronic address:

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December 2014

Evaluation of the noise exposure of symphonic orchestra musicians.

Noise Health 2014 Jan-Feb;16(68):40-6

Department of Environmental Health, Research Centre on Environment and Health, Allied Health Sciences School of Polytechnic Institute of Porto, Vila Nova de Gaia, Portugal.

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May 2014

Effects of storage, processing and proteolytic digestion on microcystin-LR concentration in edible clams.

Food Chem Toxicol 2014 Apr 31;66:217-23. Epub 2014 Jan 31.

CIIMAR/CIMAR - Interdisciplinary Centre of Marine and Environmental Research, University of Porto, Rua dos Bragas 289, P 4050-123 Porto, Portugal; Faculty of Sciences, University of Porto, Rua do Campo Alegre, 4169-007 Porto, Portugal. Electronic address:

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April 2014

Carotenoids inhibit lipid peroxidation and hemoglobin oxidation, but not the depletion of glutathione induced by ROS in human erythrocytes.

Life Sci 2014 Mar 28;99(1-2):52-60. Epub 2014 Jan 28.

REQUIMTE, Department of Chemical Sciences, Faculty of Pharmacy, University of Porto (FFUP), 4050-313 Porto, Portugal. Electronic address:

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March 2014

Inhibition of LOX by flavonoids: a structure-activity relationship study.

Eur J Med Chem 2014 Jan 10;72:137-45. Epub 2013 Dec 10.

REQUIMTE, Departamento de Ciências Químicas, Faculdade de Farmácia, Universidade do Porto, Rua Jorge Viterbo Ferreira n° 228, 4050-313 Porto, Portugal. Electronic address:

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January 2014

Interaction of polyacrylic acid coated and non-coated iron oxide nanoparticles with human neutrophils.

Toxicol Lett 2014 Feb 26;225(1):57-65. Epub 2013 Nov 26.

REQUIMTE, Laboratory of Applied Chemistry, Department of Chemical Sciences, Faculty of Pharmacy, University of Porto, Porto, Portugal. Electronic address:

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February 2014

Modulation of human neutrophils' oxidative burst by flavonoids.

Eur J Med Chem 2013 Sep 21;67:280-92. Epub 2013 Jun 21.

REQUIMTE, Laboratório de Química Aplicada, Departamento de Ciências Químicas, Faculdade de Farmácia, Universidade do Porto, 4050-313 Porto, Portugal.

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September 2013

Acetaminophen prevents oxidative burst and delays apoptosis in human neutrophils.

Toxicol Lett 2013 May 18;219(2):170-7. Epub 2013 Mar 18.

REQUIMTE, Departamento de Ciências Químicas, Laboratório de Química Aplicada, Faculdade de Farmácia, Universidade do Porto, Porto, Portugal.

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May 2013

Nickel induces apoptosis in human neutrophils.

Biometals 2013 Feb 25;26(1):13-21. Epub 2012 Oct 25.

REQUIMTE, Departamento de Ciências Químicas, Faculdade de Farmácia, Universidade do Porto, Rua de Jorge Viterbo Ferreira no. 228, 4050-313, Porto, Portugal.

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February 2013

The potential of extracts of Caryocar villosum pulp to scavenge reactive oxygen and nitrogen species.

Food Chem 2012 Dec 28;135(3):1740-9. Epub 2012 Jun 28.

Department of Food Science, Faculty of Food Engineering, University of Campinas (UNICAMP), 13083-862 Campinas, São Paulo, Brazil.

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December 2012

Trihydroxyflavones with antioxidant and anti-inflammatory efficacy.

Biofactors 2012 Sep-Oct;38(5):378-86. Epub 2012 Jul 17.

REQUIMTE, Departamento de Ciências Químicas, Universidade do Porto, Porto, Portugal.

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March 2013

Indole based cyclooxygenase inhibitors: synthesis, biological evaluation, docking and NMR screening.

Eur J Med Chem 2012 Aug 29;54:823-33. Epub 2012 Jun 29.

REQUIMTE-CQFB, Departamento de Química, Faculdade de Ciências e Tecnologia, Universidade Nova de Lisboa, Monte de Caparica, 2829-516 Caparica, Portugal.

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August 2012

Seasonal dynamics of Microcystis spp. and their toxigenicity as assessed by qPCR in a temperate reservoir.

Mar Drugs 2011 29;9(10):1715-30. Epub 2011 Sep 29.

CIIMAR/CIMAR, Marine and Environmental Research Centre, Porto University, Rua dos Bragas, 289, Porto 4050-123, Portugal.

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February 2013

Zinc, cadmium and nickel increase the activation of NF-κB and the release of cytokines from THP-1 monocytic cells.

Metallomics 2011 Nov 15;3(11):1238-43. Epub 2011 Aug 15.

REQUIMTE, Departamento de Ciências Químicas, Faculdade de Farmácia, Universidade do Porto, Rua Aníbal Cunha, 164, 4099-030 Porto, Portugal.

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November 2011

Colour score as a guide for estimating the protein value of corn gluten feed.

J Sci Food Agric 2011 Jul 28;91(9):1648-52. Epub 2011 Mar 28.

REQUIMTE, Departamento de Geociências, Ambiente e Ordenamento do Território, Faculdade de Ciências, Universidade do Porto, 4485-661 Vairão VC, Portugal.

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July 2011

Antioxidant activity of unexplored indole derivatives: synthesis and screening.

Eur J Med Chem 2010 Nov 6;45(11):4869-78. Epub 2010 Aug 6.

REQUIMTE-CQFB, Departamento de Química, Faculdade de Ciências e Tecnologia, Universidade Nova de Lisboa, Monte de Caparica, 2829-516 Caparica, Portugal.

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November 2010

2,3-diarylxanthones as strong scavengers of reactive oxygen and nitrogen species: a structure-activity relationship study.

Bioorg Med Chem 2010 Sep 25;18(18):6776-84. Epub 2010 Jul 25.

Departamento de Produção e Tecnologia Vegetal, Escola Superior Agrária de Bragança, 5301-855 Bragança, Portugal.

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September 2010

Nickel induces oxidative burst, NF-κB activation and interleukin-8 production in human neutrophils.

J Biol Inorg Chem 2010 Nov 15;15(8):1275-83. Epub 2010 Jul 15.

REQUIMTE, Departamento de Química, Faculdade de Farmácia, Universidade do Porto, Rua Aníbal Cunha, 164, 4099-030, Porto, Portugal.

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November 2010

Biological activities of 2-styrylchromones.

Mini Rev Med Chem 2010 Jan;10(1):1-7

REQUIMTE, Departamento de Química-Física, Faculdade de Farmácia, Universidade do Porto, Rua Aníbal Cunha 164, Porto, Portugal.

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January 2010

Synthesis and antioxidant properties of new chromone derivatives.

Bioorg Med Chem 2009 Oct 3;17(20):7218-26. Epub 2009 Sep 3.

REQUIMTE, Departamento de Química-Física, Faculdade de Farmácia, Universidade do Porto, Rua Aníbal Cunha, 164, 4099-030 Porto, Portugal.

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October 2009

Zinc activates neutrophils' oxidative burst.

Biometals 2010 Feb 17;23(1):31-41. Epub 2009 Sep 17.

REQUIMTE, Departamento de Química-Física, Faculdade de Farmácia, Universidade do Porto, Rua Aníbal Cunha 164, 4099-030, Porto, Portugal.

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February 2010

Optical probes for detection and quantification of neutrophils' oxidative burst. A review.

Anal Chim Acta 2009 Sep 4;649(1):8-23. Epub 2009 Jul 4.

REQUIMTE, Departamento de Química-Física, Faculdade de Farmácia, Universidade do Porto, Rua Aníbal Cunha 164, 4099-030 Porto, Portugal.

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September 2009

Optimization of experimental settings for the analysis of human neutrophils oxidative burst in vitro.

Talanta 2009 Jun 9;78(4-5):1476-83. Epub 2009 Mar 9.

REQUIMTE, Departamento de Química-Física, Universidade do Porto, Rua Aníbal Cunha 164, Porto 4099-030, Portugal.

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June 2009

Isolation and activation of human neutrophils in vitro. The importance of the anticoagulant used during blood collection.

Clin Biochem 2008 May 11;41(7-8):570-5. Epub 2008 Jan 11.

REQUIMTE, Physical-Chemistry Department, Faculty of Pharmacy, University of Porto, Rua Aníbal Cunha 164, 4099-030 Porto, Portugal.

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May 2008