Publications by authors named "Mariona Graupera"

46Publications

Revisiting PI3-kinase signalling in angiogenesis.

Vasc Biol 2019 29;1(1):H125-H134. Epub 2019 Nov 29.

Vascular Biology and Signalling Group, Program Against Cancer Therapeutic Resistance (ProCURE), Institut d'Investigació Biomèdica de Bellvitge (IDIBELL), L'Hospitalet de Llobregat-Barcelona, Spain.

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http://dx.doi.org/10.1530/VB-19-0025DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7439845PMC
November 2019

Phosphoinositide 3-Kinase-Regulated Pericyte Maturation Governs Vascular Remodeling.

Circulation 2020 Aug 29;142(7):688-704. Epub 2020 May 29.

Vascular Biology and Signalling Group, ProCURE, Oncobell Program, Institut d´Investigació Biomèdica de Bellvitge (IDIBELL), Gran Via de l'Hospitalet 199, 08908 L´Hospitalet de Llobregat, Barcelona, Spain (A.M.F., P.V., P.K., A.M.-R., A.A.-U., M.G.).

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http://dx.doi.org/10.1161/CIRCULATIONAHA.119.042354DOI Listing
August 2020

Re-education of Tumor-Associated Macrophages by CXCR2 Blockade Drives Senescence and Tumor Inhibition in Advanced Prostate Cancer.

Cell Rep 2019 08;28(8):2156-2168.e5

Institute of Oncology Research (IOR), 6500 Bellinzona, Switzerland; Faculty of Medicine, Università della Svizzera Italiana, 1011 Lugano, Switzerland; Department of Medicine, University of Padua, 35131 Padua, Italy; Medical Oncology, Oncology Institute of Southern Switzerland, 6500 Bellinzona, Switzerland. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2019.07.068DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6715643PMC
August 2019

Antitumor Effects of Anti-Semaphorin 4D Antibody Unravel a Novel Proinvasive Mechanism of Vascular-Targeting Agents.

Cancer Res 2019 Oct 25;79(20):5328-5341. Epub 2019 Jun 25.

Tumor Angiogenesis Group, ProCURE Research Program, Catalan Institute of Oncology, OncoBell Program, IDIBELL, Barcelona, Spain.

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http://dx.doi.org/10.1158/0008-5472.CAN-18-3436DOI Listing
October 2019

PIK3CA mutations in vascular malformations.

Curr Opin Hematol 2019 05;26(3):170-178

Vascular Signalling Laboratory, Program Against Cancer Therapeutic Resistance (ProCURE), Institut d'Investigació Biomèdica de Bellvitge (IDIBELL).

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http://dx.doi.org/10.1097/MOH.0000000000000496DOI Listing
May 2019

Endothelial Cells: New Players in Obesity and Related Metabolic Disorders.

Trends Endocrinol Metab 2018 11 25;29(11):781-794. Epub 2018 Sep 25.

Neuronal Control of Metabolism Laboratory, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), 08036 Barcelona, Spain; Centro de Investigación Biomédica en Red (CIBER) de Diabetes y Enfermedades Metabólicas Asociadas (CIBERDEM), 08036 Barcelona, Spain. Electronic address:

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http://dx.doi.org/10.1016/j.tem.2018.09.003DOI Listing
November 2018

DYRK1A Kinase Positively Regulates Angiogenic Responses in Endothelial Cells.

Cell Rep 2018 05;23(6):1867-1878

Centre for Genomic Regulation (CRG), The Barcelona Institute of Science and Technology, 08003 Barcelona, Spain; Centro de Investigación Biomédica en Red en Enfermedades Raras (CIBERER), Spain; Institució Catalana de Recerca i Estudis Avançats (ICREA), 08010 Barcelona, Spain. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2018.04.008DOI Listing
May 2018

ALK1 Loss Results in Vascular Hyperplasia in Mice and Humans Through PI3K Activation.

Arterioscler Thromb Vasc Biol 2018 05 15;38(5):1216-1229. Epub 2018 Feb 15.

From the Program Against Cancer Therapeutic Resistance, Institut Català d'Oncologia, Hospital Duran i Reynals (E.A.-S., Y.G.-I., A.M.F., C.R.-D., A.F., O.C., M.A.P., M.G., F.V.)

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http://dx.doi.org/10.1161/ATVBAHA.118.310760DOI Listing
May 2018

A Role for CXCR4 in Peritoneal and Hematogenous Ovarian Cancer Dissemination.

Mol Cancer Ther 2018 02 16;17(2):532-543. Epub 2017 Nov 16.

Program Against Cancer Therapeutic Resistance (ProCURE), Institut Català d'Oncologia, Hospital Duran i Reynals, Barcelona, Spain.

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http://dx.doi.org/10.1158/1535-7163.MCT-17-0643DOI Listing
February 2018

Therapeutic Benefit of Selective Inhibition of p110α PI3-Kinase in Pancreatic Neuroendocrine Tumors.

Clin Cancer Res 2016 Dec 25;22(23):5805-5817. Epub 2016 May 25.

Vascular Signaling Laboratory, Institut d'Investigació Biomèdica de Bellvitge (IDIBELL), L'Hospitalet de Llobregat, Barcelona, Spain.

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http://dx.doi.org/10.1158/1078-0432.CCR-15-3051DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5338478PMC
December 2016

Targeting PI3K in Cancer: Impact on Tumor Cells, Their Protective Stroma, Angiogenesis, and Immunotherapy.

Cancer Discov 2016 10 21;6(10):1090-1105. Epub 2016 Sep 21.

UCL Cancer Institute, University College London, London, United Kingdom.

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http://dx.doi.org/10.1158/2159-8290.CD-16-0716DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5293166PMC
October 2016

The TGFβ pathway stimulates ovarian cancer cell proliferation by increasing IGF1R levels.

Int J Cancer 2016 10 25;139(8):1894-903. Epub 2016 Jun 25.

Program Against Cancer Therapeutic Resistance (ProCURE), Institut Català D'Oncologia (ICO), Hospital Duran i Reynals, L'Hospitalet de Llobregat, Barcelona, Spain.

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http://dx.doi.org/10.1002/ijc.30233DOI Listing
October 2016

Class I PI-3-Kinase Signaling Is Critical for Bone Formation Through Regulation of SMAD1 Activity in Osteoblasts.

J Bone Miner Res 2016 08 15;31(8):1617-30. Epub 2016 Mar 15.

Departament de Ciències Fisiològiques II, Universitat de Barcelona, IDIBELL, L'Hospitalet de Llobregat, Barcelona, Spain.

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http://dx.doi.org/10.1002/jbmr.2819DOI Listing
August 2016

Sequential Functions of CPEB1 and CPEB4 Regulate Pathologic Expression of Vascular Endothelial Growth Factor and Angiogenesis in Chronic Liver Disease.

Gastroenterology 2016 Apr 26;150(4):982-97.e30. Epub 2015 Nov 26.

Program of Molecular Medicine, Institute for Research in Biomedicine (IRB Barcelona), The Barcelona Institute of Science and Technology, Barcelona, Spain; Institucio Catalana de Recerca i Estudis Avançats (ICREA), Barcelona, Spain. Electronic address:

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http://dx.doi.org/10.1053/j.gastro.2015.11.038DOI Listing
April 2016

PI3K at the crossroads of tumor angiogenesis signaling pathways.

Mol Cell Oncol 2015 Apr-Jun;2(2):e975624. Epub 2015 Feb 26.

Vascular Signalling Lab; Angiogenesis Unit, Institut d'Investigació Biomèdica de Bellvitge (IDIBELL) ; Barcelona, Spain.

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http://dx.doi.org/10.4161/23723556.2014.975624DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4905058PMC
June 2016

cKit Lineage Hemogenic Endothelium-Derived Cells Contribute to Mesenteric Lymphatic Vessels.

Cell Rep 2015 Mar 12;10(10):1708-1721. Epub 2015 Mar 12.

The Beijer Laboratory, Department of Immunology, Genetics and Pathology, Uppsala University, Dag Hammarskjöldsväg 20, 752 85 Uppsala, Sweden; Lymphatic Development Laboratory, Cancer Research UK London Research Institute (LRI), 44 Lincoln's Inn Fields, London WC2A 3LY, UK. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2015.02.026DOI Listing
March 2015

Inhibition of the p110α isoform of PI 3-kinase stimulates nonfunctional tumor angiogenesis.

J Exp Med 2013 Sep 16;210(10):1937-45. Epub 2013 Sep 16.

Vascular Signaling Laboratory; and 2 Translational Research Laboratory, Catalan Institute of Oncology, Institut d'Investigació Biomèdica de Bellvitge (IDIBELL), 08907 L'Hospitalet de Llobregat, Barcelona, Spain.

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http://dx.doi.org/10.1084/jem.20121571DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3782054PMC
September 2013

Effectivity of pazopanib treatment in orthotopic models of human testicular germ cell tumors.

BMC Cancer 2013 Aug 10;13:382. Epub 2013 Aug 10.

Laboratori de Recerca Translacional, Institut Català d'Oncologia, Hospital Duran i Reynals, L'Hospitalet de Llobregat, Barcelona, 08908, Spain.

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http://dx.doi.org/10.1186/1471-2407-13-382DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3751347PMC
August 2013

Metronomic chemotherapy following the maximum tolerated dose is an effective anti-tumour therapy affecting angiogenesis, tumour dissemination and cancer stem cells.

Int J Cancer 2013 Nov 4;133(10):2464-72. Epub 2013 Jun 4.

Translational Research Laboratory, Catalan Institute of Oncology, IDIBELL, Hospital Duran i Reynals, L'Hospitalet de Llobregat, Barcelona, Spain.

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http://dx.doi.org/10.1002/ijc.28259DOI Listing
November 2013

Regulation of angiogenesis by PI3K signaling networks.

Exp Cell Res 2013 May 13;319(9):1348-55. Epub 2013 Mar 13.

Vascular Signalling Lab, Angiogenesis Unit, Institut d´Investigació Biomèdica de Bellvitge (IDIBELL), 3a planta-Gran Via de l'Hospitalet, 199-203, 08908 L'Hospitalet de Llobregat, Barcelona, Spain.

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http://dx.doi.org/10.1016/j.yexcr.2013.02.021DOI Listing
May 2013

The emerging mechanisms of isoform-specific PI3K signalling.

Nat Rev Mol Cell Biol 2010 May 9;11(5):329-41. Epub 2010 Apr 9.

Centre for Cell Signalling, Institute of Cancer, Queen Mary University of London, Charterhouse Square, London, UK.

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http://dx.doi.org/10.1038/nrm2882DOI Listing
May 2010

Angiogenesis selectively requires the p110alpha isoform of PI3K to control endothelial cell migration.

Nature 2008 May 30;453(7195):662-6. Epub 2008 Apr 30.

Centre for Cell Signalling, Institute of Cancer, Queen Mary, University of London, Charterhouse Square, London EC1M 6BQ, UK.

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http://dx.doi.org/10.1038/nature06892DOI Listing
May 2008

Large-conductance calcium-activated potassium channels modulate vascular tone in experimental cirrhosis.

Liver Int 2008 Apr;28(4):566-73

Hepatic Hemodynamic Laboratory, Liver Unit, Institut Malalties Digestives i Metabòliques, Hospital Clínic, Institut d'Investigacions Biomèdiques August Pi i Sunyer, Ciberehd, Barcelona, Spain.

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http://dx.doi.org/10.1111/j.1478-3231.2008.01668.xDOI Listing
April 2008

Simvastatin treatment improves liver sinusoidal endothelial dysfunction in CCl4 cirrhotic rats.

J Hepatol 2007 Jun 15;46(6):1040-6. Epub 2007 Feb 15.

Hepatic Hemodynamic Laboratory, Liver Unit, IMDIM, Hospital Clínic, Ciberehd, University of Barcelona, Villarroel 170, 08036 Barcelona, Spain.

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http://dx.doi.org/10.1016/j.jhep.2007.01.020DOI Listing
June 2007

Identification and functional characterization of the hepatic stellate cell CD38 cell surface molecule.

Am J Pathol 2007 Jan;170(1):176-87

Immunology Unit, Department of Cellular Biology and Pathology, Medical School, University of Barcelona, Barcelona, Spain.

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http://linkinghub.elsevier.com/retrieve/pii/S000294401060844
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http://dx.doi.org/10.2353/ajpath.2007.051212DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1762705PMC
January 2007

Ultrasensitive and absolute quantification of the phosphoinositide 3-kinase/Akt signal transduction pathway by mass spectrometry.

Proc Natl Acad Sci U S A 2006 Jun 2;103(24):8959-64. Epub 2006 Jun 2.

Cell Signaling in Cancer Laboratory, Ludwig Institute for Cancer Research, 91 Riding House Street, London W1W 7BS, United Kingdom.

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http://dx.doi.org/10.1073/pnas.0602101103DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1482548PMC
June 2006

Sinusoidal endothelial COX-1-derived prostanoids modulate the hepatic vascular tone of cirrhotic rat livers.

Am J Physiol Gastrointest Liver Physiol 2005 Apr 18;288(4):G763-70. Epub 2004 Nov 18.

Hepatic Hemodynamic Laboratory, Hospital Clínic, Villarroel 170, 08036 Barcelona, Spain.

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http://dx.doi.org/10.1152/ajpgi.00300.2004DOI Listing
April 2005

Cyclooxygenase-1 inhibition corrects endothelial dysfunction in cirrhotic rat livers.

J Hepatol 2003 Oct;39(4):515-21

Hepatic Hemodynamic Laboratory, Liver Unit, Institut Malalties Digestives, Hospital Clínic, Institut d'Investigacions Biomèdiques August Pi i Sunyer, University of Barcelona, Villarroel 170, 08036 Barcelona, Spain.

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http://dx.doi.org/10.1016/s0168-8278(03)00347-7DOI Listing
October 2003

Left ventricular hypertrophy in rats with biliary cirrhosis.

Hepatology 2003 Sep;38(3):589-98

Servicio de Cardiología, Hospital Universitari Vall d'Hebron, Barcelona, Spain.

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http://dx.doi.org/10.1053/jhep.2003.50369DOI Listing
September 2003

Cyclooxygenase-derived products modulate the increased intrahepatic resistance of cirrhotic rat livers.

Hepatology 2003 Jan;37(1):172-81

Hepatic Hemodynamic Laboratory, Liver Unit, Institut Malalties Digestives, University of Barcelona, Spain.

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http://dx.doi.org/10.1053/jhep.2003.50004DOI Listing
January 2003

5-lipoxygenase inhibition reduces intrahepatic vascular resistance of cirrhotic rat livers: a possible role of cysteinyl-leukotrienes.

Gastroenterology 2002 Feb;122(2):387-93

Hepatic Hemodynamic Laboratory, Liver Unit, Institut Malaties Digestives Hospital Clinic, University of Barcelona, Barcelona, Spain.

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http://dx.doi.org/10.1053/gast.2002.31040DOI Listing
February 2002