Marion MacFarlane

Marion MacFarlane

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Marion MacFarlane

Marion MacFarlane

Publications by authors named "Marion MacFarlane"

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Evaluation of apoptosis imaging biomarkers in a genetic model of cell death.

EJNMMI Res 2019 Feb 19;9(1):18. Epub 2019 Feb 19.

Cancer Imaging Centre, Department of Surgery and Cancer, Faculty of Medicine, Imperial College London, Hammersmith Hospital Campus, Du Cane Road, London, W12 0NN, UK.

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http://dx.doi.org/10.1186/s13550-019-0487-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6381199PMC
February 2019

Asbestos: Modern Insights for Toxicology in the Era of Engineered Nanomaterials.

Chem Res Toxicol 2018 10 12;31(10):994-1008. Epub 2018 Sep 12.

MRC Toxicology Unit , University of Cambridge , Hodgkin Building, Leicester LE1 9HN , United Kingdom.

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http://dx.doi.org/10.1021/acs.chemrestox.8b00146DOI Listing
October 2018

N-glycosylation of mouse TRAIL-R restrains TRAIL-induced apoptosis.

Cell Death Dis 2018 05 1;9(5):494. Epub 2018 May 1.

VIB Center for Inflammation Research, Technologiepark 927, Zwijnaarde-Ghent, 9052, Belgium.

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http://dx.doi.org/10.1038/s41419-018-0544-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5931557PMC
May 2018

Molecular mechanisms of cell death: recommendations of the Nomenclature Committee on Cell Death 2018.

Authors:
Lorenzo Galluzzi Ilio Vitale Stuart A Aaronson John M Abrams Dieter Adam Patrizia Agostinis Emad S Alnemri Lucia Altucci Ivano Amelio David W Andrews Margherita Annicchiarico-Petruzzelli Alexey V Antonov Eli Arama Eric H Baehrecke Nickolai A Barlev Nicolas G Bazan Francesca Bernassola Mathieu J M Bertrand Katiuscia Bianchi Mikhail V Blagosklonny Klas Blomgren Christoph Borner Patricia Boya Catherine Brenner Michelangelo Campanella Eleonora Candi Didac Carmona-Gutierrez Francesco Cecconi Francis K-M Chan Navdeep S Chandel Emily H Cheng Jerry E Chipuk John A Cidlowski Aaron Ciechanover Gerald M Cohen Marcus Conrad Juan R Cubillos-Ruiz Peter E Czabotar Vincenzo D'Angiolella Ted M Dawson Valina L Dawson Vincenzo De Laurenzi Ruggero De Maria Klaus-Michael Debatin Ralph J DeBerardinis Mohanish Deshmukh Nicola Di Daniele Francesco Di Virgilio Vishva M Dixit Scott J Dixon Colin S Duckett Brian D Dynlacht Wafik S El-Deiry John W Elrod Gian Maria Fimia Simone Fulda Ana J García-Sáez Abhishek D Garg Carmen Garrido Evripidis Gavathiotis Pierre Golstein Eyal Gottlieb Douglas R Green Lloyd A Greene Hinrich Gronemeyer Atan Gross Gyorgy Hajnoczky J Marie Hardwick Isaac S Harris Michael O Hengartner Claudio Hetz Hidenori Ichijo Marja Jäättelä Bertrand Joseph Philipp J Jost Philippe P Juin William J Kaiser Michael Karin Thomas Kaufmann Oliver Kepp Adi Kimchi Richard N Kitsis Daniel J Klionsky Richard A Knight Sharad Kumar Sam W Lee John J Lemasters Beth Levine Andreas Linkermann Stuart A Lipton Richard A Lockshin Carlos López-Otín Scott W Lowe Tom Luedde Enrico Lugli Marion MacFarlane Frank Madeo Michal Malewicz Walter Malorni Gwenola Manic Jean-Christophe Marine Seamus J Martin Jean-Claude Martinou Jan Paul Medema Patrick Mehlen Pascal Meier Sonia Melino Edward A Miao Jeffery D Molkentin Ute M Moll Cristina Muñoz-Pinedo Shigekazu Nagata Gabriel Nuñez Andrew Oberst Moshe Oren Michael Overholtzer Michele Pagano Theocharis Panaretakis Manolis Pasparakis Josef M Penninger David M Pereira Shazib Pervaiz Marcus E Peter Mauro Piacentini Paolo Pinton Jochen H M Prehn Hamsa Puthalakath Gabriel A Rabinovich Markus Rehm Rosario Rizzuto Cecilia M P Rodrigues David C Rubinsztein Thomas Rudel Kevin M Ryan Emre Sayan Luca Scorrano Feng Shao Yufang Shi John Silke Hans-Uwe Simon Antonella Sistigu Brent R Stockwell Andreas Strasser Gyorgy Szabadkai Stephen W G Tait Daolin Tang Nektarios Tavernarakis Andrew Thorburn Yoshihide Tsujimoto Boris Turk Tom Vanden Berghe Peter Vandenabeele Matthew G Vander Heiden Andreas Villunger Herbert W Virgin Karen H Vousden Domagoj Vucic Erwin F Wagner Henning Walczak David Wallach Ying Wang James A Wells Will Wood Junying Yuan Zahra Zakeri Boris Zhivotovsky Laurence Zitvogel Gerry Melino Guido Kroemer

Cell Death Differ 2018 03 23;25(3):486-541. Epub 2018 Jan 23.

Paris Descartes/Paris V University, Paris, France.

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http://dx.doi.org/10.1038/s41418-017-0012-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5864239PMC
March 2018

Caspase-10 Negatively Regulates Caspase-8-Mediated Cell Death, Switching the Response to CD95L in Favor of NF-κB Activation and Cell Survival.

Cell Rep 2017 04;19(4):785-797

Section of Molecular Dermatology, Department of Dermatology, Venereology, and Allergology, Medical Faculty Mannheim, University of Heidelberg, Theodor-Kutzer-Ufer 1-3, 68167 Mannheim, Germany; Department of Dermatology and Allergology, Medical Faculty of the RWTH Aachen, Pauwelsstraße 30, 52074 Aachen, Germany.

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http://dx.doi.org/10.1016/j.celrep.2017.04.010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5413585PMC
April 2017

Targeting cell death signalling in cancer: minimising 'Collateral damage'.

Br J Cancer 2016 Jun 3;115(1):5-11. Epub 2016 May 3.

MRC Toxicology Unit, Hodgkin Building, PO Box 138, Lancaster Road, Leicester LE1 9HN, UK.

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http://dx.doi.org/10.1038/bjc.2016.111DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4931361PMC
June 2016

In Vitro Assembly and Analysis of the Apoptosome Complex.

Cold Spring Harb Protoc 2015 Dec 2;2015(12):pdb.prot087080. Epub 2015 Dec 2.

MRC Toxicology Unit, Hodgkin Building, Leicester LE1 9HN, United Kingdom.

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http://dx.doi.org/10.1101/pdb.prot087080DOI Listing
December 2015

Activation, Isolation, and Analysis of the Death-Inducing Signaling Complex.

Cold Spring Harb Protoc 2015 Dec 2;2015(12):pdb.prot087098. Epub 2015 Dec 2.

MRC Toxicology Unit, Hodgkin Building, Leicester, LE1 9HN, United Kingdom.

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http://dx.doi.org/10.1101/pdb.prot087098DOI Listing
December 2015

Biochemical Analysis of Initiator Caspase-Activating Complexes: The Apoptosome and the Death-Inducing Signaling Complex.

Cold Spring Harb Protoc 2015 Dec 2;2015(12):pdb.top070326. Epub 2015 Dec 2.

MRC Toxicology Unit, Hodgkin Building, Leicester LE1 9HN, United Kingdom.

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http://dx.doi.org/10.1101/pdb.top070326DOI Listing
December 2015

Autophagy limits proliferation and glycolytic metabolism in acute myeloid leukemia.

Cell Death Discov 2015 Aug;1

Translational Immunology Lab, BRC- NIHR, John Radcliffe Hospital, Experimental Medicine, Nuffield Department of Medicine, Oxford OX3 9DU, UK ; MRC Human Immunology Unit, Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, Oxford OX3 9DS, UK.

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http://search.proquest.com/openview/620e53d7bdb55fb4e8cad3e6
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http://www.nature.com/articles/cddiscovery20158
Publisher Site
http://dx.doi.org/10.1038/cddiscovery.2015.8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4641322PMC
August 2015

Notch4 Signaling Confers Susceptibility to TRAIL-Induced Apoptosis in Breast Cancer Cells.

J Cell Biochem 2015 Jul;116(7):1371-80

National Centre for Biological Sciences, Tata Institute of Fundamental Research, Bangalore, 560065, Karnataka, India.

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http://dx.doi.org/10.1002/jcb.25094DOI Listing
July 2015

Modulation of the sensitivity of Jurkat T-cells to inhibition of protein synthesis by tumor necrosis factor α-related apoptosis-inducing ligand.

J Interferon Cytokine Res 2014 Oct 14;34(10):769-77. Epub 2014 Apr 14.

1 Translational Control Group, Molecular Cell Sciences Research Centre, St George's, University of London , London, United Kingdom .

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http://dx.doi.org/10.1089/jir.2013.0061DOI Listing
October 2014

Pulmonary toxicity of carbon nanotubes and asbestos - similarities and differences.

Adv Drug Deliv Rev 2013 Dec 27;65(15):2078-86. Epub 2013 Jul 27.

MRC/University of Edinburgh, Centre for Inflammation Research, Queen's Medical Research Institute, 47 Little France Crescent, Edinburgh EH16 4TJ, United Kingdom. Electronic address:

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http://dx.doi.org/10.1016/j.addr.2013.07.014DOI Listing
December 2013

Isolation, characterisation and reconstitution of cell death signalling complexes.

Methods 2013 Jun 26;61(2):98-104. Epub 2013 Feb 26.

MRC Toxicology Unit, Hodgkin Building, PO Box 138, University of Leicester, Lancaster Road, Leicester LE1 9HN, UK.

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http://dx.doi.org/10.1016/j.ymeth.2013.02.006DOI Listing
June 2013

Glucose--a sweet way to die: metabolic switching modulates tumor cell death.

Cell Cycle 2012 Nov 14;11(21):3919-25. Epub 2012 Sep 14.

MRC Toxicology Unit, University of Leicester, Leicester, UK.

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http://dx.doi.org/10.4161/cc.21804DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3507486PMC
November 2012

The 'complexities' of life and death: death receptor signalling platforms.

Exp Cell Res 2012 Jul 17;318(11):1269-77. Epub 2012 Apr 17.

MRC Toxicology Unit, University of Leicester, Leicester, UK.

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http://dx.doi.org/10.1016/j.yexcr.2012.04.005DOI Listing
July 2012

The Ripoptosome, a signaling platform that assembles in response to genotoxic stress and loss of IAPs.

Mol Cell 2011 Aug 7;43(3):432-48. Epub 2011 Jul 7.

The Breakthrough Toby Robins Breast Cancer Research Centre, Institute of Cancer Research, London, UK.

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http://dx.doi.org/10.1016/j.molcel.2011.06.006DOI Listing
August 2011

Disassembly of the JIP1/JNK molecular scaffold by caspase-3-mediated cleavage of JIP1 during apoptosis.

Exp Cell Res 2011 Apr 13;317(7):1028-39. Epub 2011 Jan 13.

Department of Biochemistry, Henry Wellcome Building, University of Leicester, Lancaster Road, Leicester LE1 9HN, UK.

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http://dx.doi.org/10.1016/j.yexcr.2011.01.011DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3063339PMC
April 2011

Mitochondrial fragmentation and neuronal cell death in response to the Bcl-2/Bcl-x(L)/Bcl-w antagonist ABT-737.

Neuropharmacology 2010 Jun 20;58(8):1258-67. Epub 2010 Mar 20.

MRC Toxicology Unit, University of Leicester, Hodgkin Building, Lancaster Road, Leicester LE1 9HN, UK.

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http://dx.doi.org/10.1016/j.neuropharm.2010.03.008DOI Listing
June 2010

Recombinant TRAIL and TRAIL receptor analysis.

Methods Enzymol 2008 ;446:293-313

MRC Toxicology Unit, University of Leicester, Leicester, LE1 9HN, UK.

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http://dx.doi.org/10.1016/S0076-6879(08)01618-2DOI Listing
August 2008

Increased hepatotoxicity of tumor necrosis factor-related apoptosis-inducing ligand in diseased human liver.

Hepatology 2007 Nov;46(5):1498-508

Department of Gastroenterology, Hepatology and Endocrinology, Hannover Medical School, Hannover, Germany.

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http://dx.doi.org/10.1002/hep.21846DOI Listing
November 2007

Caspase-7 is directly activated by the approximately 700-kDa apoptosome complex and is released as a stable XIAP-caspase-7 approximately 200-kDa complex.

J Biol Chem 2006 Feb 13;281(7):3876-88. Epub 2005 Dec 13.

Medical Research Council Toxicology Unit, Hodgkin Building, University of Leicester, UK.

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http://dx.doi.org/10.1074/jbc.M507393200DOI Listing
February 2006

TRAIL receptor-selective mutants signal to apoptosis via TRAIL-R1 in primary lymphoid malignancies.

Cancer Res 2005 Dec;65(24):11265-70

Medical Research Council, Toxicology Unit, Hodgkin Building, University of Leicester, UK.

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http://dx.doi.org/10.1158/0008-5472.CAN-05-2801DOI Listing
December 2005

Caspase-3 expression is reduced, in the absence of cleavage, in terminally differentiated normal oral epithelium but is increased in oral squamous cell carcinomas and correlates with tumour stage.

J Pathol 2004 Oct;204(2):175-82

Department of Oral and Dental Science, University of Bristol Dental School, Lower Maudlin Street, Bristol, BS1 2LY, UK.

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http://dx.doi.org/10.1002/path.1630DOI Listing
October 2004

Apoptosis and disease: a life or death decision.

EMBO Rep 2004 Jul 25;5(7):674-8. Epub 2004 Jun 25.

MRC Toxicology Unit, Hodgkin Building, University of Leicester, Leicester LE1 9HN, UK.

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http://dx.doi.org/10.1038/sj.embor.7400191DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1299101PMC
July 2004

Pro-apoptotic proteins released from the mitochondria regulate the protein composition and caspase-processing activity of the native Apaf-1/caspase-9 apoptosome complex.

J Biol Chem 2004 May 1;279(19):19665-82. Epub 2004 Mar 1.

Medical Research Council Toxicology Unit, Hodgkin Building, University of Leicester, Leicester LE1 9HN, United Kingdom.

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http://dx.doi.org/10.1074/jbc.M311388200DOI Listing
May 2004

Caspase activation inhibits proteasome function during apoptosis.

Mol Cell 2004 Apr;14(1):81-93

MRC Toxicology Unit, Hodgkin Building, University of Leicester, PO Box 138, Lancaster Road, Leicester, LE1 9HN, United Kingdom.

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http://dx.doi.org/10.1016/s1097-2765(04)00156-xDOI Listing
April 2004

Protein kinase C modulates tumor necrosis factor-related apoptosis-inducing ligand-induced apoptosis by targeting the apical events of death receptor signaling.

J Biol Chem 2003 Nov 14;278(45):44338-47. Epub 2003 Aug 14.

Medical Research Council Toxicology Unit, University of Leicester, Hodgkin Bldg., P. O. Box 138, Lancaster Rd., Leicester LE1 9HN, United Kingdom.

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http://www.jbc.org/content/278/45/44338.full.pdf
Web Search
http://www.jbc.org/cgi/doi/10.1074/jbc.M307376200
Publisher Site
http://dx.doi.org/10.1074/jbc.M307376200DOI Listing
November 2003

Fas-associated death domain protein and caspase-8 are not recruited to the tumor necrosis factor receptor 1 signaling complex during tumor necrosis factor-induced apoptosis.

J Biol Chem 2003 Jul 29;278(28):25534-41. Epub 2003 Apr 29.

Medical Research Council Toxicology Unit, Hodgkin Building, University of Leicester, P.O. Box 138, Lancaster Road, Leicester, LE1 9HN, United Kingdom.

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http://dx.doi.org/10.1074/jbc.M303399200DOI Listing
July 2003

TRAIL-induced signalling and apoptosis.

Toxicol Lett 2003 Apr;139(2-3):89-97

MRC Toxicology Unit, Hodgkin Building, University of Leicester, Lancaster Road, Leicester LE19HN, UK.

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http://dx.doi.org/10.1016/s0378-4274(02)00422-8DOI Listing
April 2003

Mechanisms of resistance to TRAIL-induced apoptosis in primary B cell chronic lymphocytic leukaemia.

Oncogene 2002 Oct;21(44):6809-18

MRC Toxicology Unit, Hodgkin Building, University of Leicester, PO Box 138, Lancaster Road, Leicester LE1 9HN, UK.

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http://dx.doi.org/10.1038/sj.onc.1205853DOI Listing
October 2002

Proteasome-mediated degradation of Smac during apoptosis: XIAP promotes Smac ubiquitination in vitro.

J Biol Chem 2002 Sep 16;277(39):36611-6. Epub 2002 Jul 16.

Medical Research Council Toxicology Unit, Hodgkin Building, University of Leicester, P. O. Box 138, Lancaster Road, Leicester LE1 9HN, United Kingdom.

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http://dx.doi.org/10.1074/jbc.M200317200DOI Listing
September 2002

Bcl-2 and Bcl-xL inhibit CD95-mediated apoptosis by preventing mitochondrial release of Smac/DIABLO and subsequent inactivation of X-linked inhibitor-of-apoptosis protein.

J Biol Chem 2002 Mar 18;277(13):11345-51. Epub 2002 Jan 18.

Medical Research Council Toxicology Unit, Hodgkin Building, University of Leicester, P. O. Box 138, Lancaster Road, Leicester LE1 9HN, United Kingdom.

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http://dx.doi.org/10.1074/jbc.M109893200DOI Listing
March 2002