Publications

The actin cytoskeleton modulates the activation of iNKT cells by segregating CD1d nanoclusters on antigen-presenting cells.
Proc Natl Acad Sci U S A 2016 Feb 21;113(6):E772-81. Epub 2016 Jan 21.
ICFO-Institut de Ciencies Fotoniques, The Barcelona Institute of Science and Technology, 08860 Barcelona, Spain; Institució Catalana de Recerca i Estudis Avançats (ICREA), 08010 Barcelona, Spain


Bee venom processes human skin lipids for presentation by CD1a.
J Exp Med 2015 Feb 12;212(2):149-63. Epub 2015 Jan 12.
MRC Human Immunology Unit, Weatherall Institute of Molecular Medicine and University of Oxford NIHR Biomedical Research Centre, Oxford, Oxfordshire OX3 9DS, England, UK MRC Human Immunology Unit, Weatherall Institute of Molecular Medicine and University of Oxford NIHR Biomedical Research Centre, Oxford, Oxfordshire OX3 9DS, England, UK

Essential role for autophagy during invariant NKT cell development.
Proc Natl Acad Sci U S A 2014 Dec 15;111(52):E5678-87. Epub 2014 Dec 15.
Medical Research Council Human Immunology Unit, Weatherall Institute of Molecular Medicine, Radcliffe Department of Medicine, University of Oxford, Headington, Oxford OX3 9DS, United Kingdom;

Saposins modulate human invariant Natural Killer T cells self-reactivity and facilitate lipid exchange with CD1d molecules during antigen presentation.
Proc Natl Acad Sci U S A 2013 Dec 18;110(49):E4753-61. Epub 2013 Nov 18.
Medical Research Council Human Immunology Unit, Radcliffe Department of Medicine, Medical Research Council Weatherall Institute of Molecular Medicine, University of Oxford, Headington, Oxford OX3 9DS, United Kingdom.



Invariant NKT cells modulate the suppressive activity of IL-10-secreting neutrophils differentiated with serum amyloid A.
Nat Immunol 2010 Nov 3;11(11):1039-46. Epub 2010 Oct 3.
Medical Research Council Human Immunology Unit, Nuffield Department of Medicine, Medical Research Council Weatherall Institute of Molecular Medicine, University of Oxford, Oxford, UK.



B cell receptor-mediated uptake of CD1d-restricted antigen augments antibody responses by recruiting invariant NKT cell help in vivo.
Proc Natl Acad Sci U S A 2008 Jun 11;105(24):8345-50. Epub 2008 Jun 11.
Lymphocyte Interaction Laboratory, Cancer Research UK London Research Institute, Lincoln's Inn Fields Laboratories, 44 Lincoln's Inn Fields, London WC2A 3PX, United Kingdom.


Down-regulation of NKG2D and NKp80 ligands by Kaposi's sarcoma-associated herpesvirus K5 protects against NK cell cytotoxicity.
Proc Natl Acad Sci U S A 2008 Feb 29;105(5):1656-61. Epub 2008 Jan 29.
Cambridge Institute for Medical Research and Department of Medicine, University of Cambridge, Hills Road, Cambridge CB2 0XY, United Kingdom.

Modulation of human natural killer T cell ligands on TLR-mediated antigen-presenting cell activation.
Proc Natl Acad Sci U S A 2007 Dec 11;104(51):20490-5. Epub 2007 Dec 11.
Tumor Immunology Group, Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, Headington, Oxford OX3 9DS, United Kingdom.



Impaired selection of invariant natural killer T cells in diverse mouse models of glycosphingolipid lysosomal storage diseases.
J Exp Med 2006 Oct 18;203(10):2293-303. Epub 2006 Sep 18.
Weatherall Institute of Molecular Medicine, Tumour Immunology Group, John Radcliffe Hospital, Oxford OX3 9DS, England, UK.

Utilizing the adjuvant properties of CD1d-dependent NK T cells in T cell-mediated immunotherapy.
J Clin Invest 2004 Dec;114(12):1800-11
Tumour Immunology Unit, Weatherall Institute of Molecular Medicine, University of Oxford, John Radcliffe Hospital, Oxford OX3 9DS, UK.



The VITAL assay: a versatile fluorometric technique for assessing CTL- and NKT-mediated cytotoxicity against multiple targets in vitro and in vivo.
J Immunol Methods 2004 Feb;285(1):25-40
Tumour Immunology Unit, Nuffield Department of Medicine, Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, University of Oxford, Oxford OX3 9DS, UK.


High avidity antigen-specific CTL identified by CD8-independent tetramer staining.
J Immunol 2003 Nov;171(10):5116-23
Tumour Immunology Unit, Nuffield Department of Medicine, Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, Oxford, United Kingdom.

NKT cells enhance CD4+ and CD8+ T cell responses to soluble antigen in vivo through direct interaction with dendritic cells.
J Immunol 2003 Nov;171(10):5140-7
Tumor Immunology Unit, Weatherall Institute of Molecular Medicine, Nuffield Department of Medicine, University of Oxford, John Radcliffe Hospital, Oxford, United Kingdom.

Lytic versus stimulatory synapse in cytotoxic T lymphocyte/target cell interaction: manifestation of a dual activation threshold.
Proc Natl Acad Sci U S A 2003 Nov 10;100(24):14145-50. Epub 2003 Nov 10.
Lymphocyte Interaction Group, Institut Claude de Préval, Institut National de la Santé et de la Recherche Médicale U563, 31059 Toulouse, France.


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