Publications by authors named "Mario Varasi"

49Publications

Tuning mTORC1 activity dictates the response of acute myeloid leukemia to LSD1 inhibition.

Haematologica 2020 Aug 19;105(8):2105-2117. Epub 2019 Sep 19.

Department of Experimental Oncology, IEO, European Institute of Oncology IRCCS, Milan, Italy

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August 2020

New targets to modulate the DNA damage response.

Future Med Chem 2018 10 16;10(20):2377-2380. Epub 2018 Oct 16.

Experimental Therapeutics Program, IFOM-FIRC Institute of Molecular Oncology Foundation, Via Adamello, 16-20139 Milano, Italy.

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October 2018

New 6- and 7-heterocyclyl-1H-indole derivatives as potent tubulin assembly and cancer cell growth inhibitors.

Eur J Med Chem 2018 May 25;152:283-297. Epub 2018 Apr 25.

Department of Drug Chemistry and Technologies, Sapienza University of Rome, Laboratory Affiliated to Istituto Pasteur Italia - Fondazione Cenci Bolognetti, Piazzale Aldo Moro 5, I-00185 Roma, Italy. Electronic address:

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May 2018

Novel potent inhibitors of the histone demethylase KDM1A (LSD1), orally active in a murine promyelocitic leukemia model.

Future Med Chem 2017 07 19;9(11):1161-1174. Epub 2017 Jul 19.

Department of Experimental Oncology, Academic Drug Discovery, European Institute of Oncology, Ifom-IEO-Campus, via Adamello 16, 20139 Milan, Italy.

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July 2017

PP2A Controls Genome Integrity by Integrating Nutrient-Sensing and Metabolic Pathways with the DNA Damage Response.

Mol Cell 2017 Jul 22;67(2):266-281.e4. Epub 2017 Jun 22.

Fondazione Istituto FIRC di Oncologia Molecolare, Via Adamello 16, 20139 Milan, Italy; Università degli Studi di Milano, 20133 Milan, Italy. Electronic address:

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July 2017

Pure enantiomers of benzoylamino-tranylcypromine: LSD1 inhibition, gene modulation in human leukemia cells and effects on clonogenic potential of murine promyelocytic blasts.

Eur J Med Chem 2015 Apr 3;94:163-74. Epub 2015 Mar 3.

Department of Drug Chemistry and Technologies, Sapienza University of Roma, P.le A. Moro 5, 00185 Roma, Italy; Pasteur Institute - Cenci Bolognetti Foundation, Sapienza University of Roma, P.le A. Moro 5, 00185 Roma, Italy. Electronic address:

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April 2015

Pure Diastereomers of a Tranylcypromine-Based LSD1 Inhibitor: Enzyme Selectivity and In-Cell Studies.

ACS Med Chem Lett 2015 Feb 8;6(2):173-7. Epub 2014 Dec 8.

Department of Drug Chemistry and Technologies, Sapienza University of Roma , P.le A. Moro 5, 00185 Roma, Italy ; Pasteur Institute-Cenci Bolognetti Foundation, Sapienza University of Roma , P.le A. Moro 5, 00185 Roma, Italy.

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February 2015