Publications by authors named "Mario Sousa"

100Publications

Epimutations in human sperm from patients with impaired spermatogenesis.

Clin Epigenetics 2020 Nov 17;12(1):172. Epub 2020 Nov 17.

Centre for Reproductive Genetics A Barros, 4100-009, Porto, Portugal.

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http://dx.doi.org/10.1186/s13148-020-00919-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7670606PMC
November 2020

Effect of Leptin in Human Sertoli Cells Mitochondrial Physiology.

Reprod Sci 2020 Sep 30. Epub 2020 Sep 30.

Department of Microscopy, Laboratory of Cell Biology, Institute of Biomedical Sciences Abel Salazar (ICBAS), University of Porto, Rua de Jorge Viterbo Ferreira n° 228, 4050-313, Porto, Portugal.

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http://dx.doi.org/10.1007/s43032-020-00328-xDOI Listing
September 2020

Mitochondrial Activation and Reactive Oxygen-Species Overproduction during Sperm Capacitation are Independent of Glucose Stimuli.

Antioxidants (Basel) 2020 Aug 14;9(8). Epub 2020 Aug 14.

Department of Microscopy, Laboratory of Cell Biology, Unit for Multidisciplinary Research in Biomedicine (UMIB), Institute of Biomedical Sciences Abel Salazar (ICBAS), University of Porto, 4050-313 Porto, Portugal.

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http://dx.doi.org/10.3390/antiox9080750DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7464989PMC
August 2020

Discordance between human sperm quality and telomere length following differential gradient separation/swim-up.

J Assist Reprod Genet 2020 Oct 7;37(10):2581-2603. Epub 2020 Aug 7.

Laboratory of Cell Biology, Department of Microscopy, Institute of Biomedical Sciences Abel Salazar, University of Porto, Rua Jorge Viterbo Ferreira, 228, 4050-313, Porto, Portugal.

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http://dx.doi.org/10.1007/s10815-020-01897-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7550483PMC
October 2020

Cognition, function and awareness of disease impact in early Parkinson's and Huntington's disease.

Disabil Rehabil 2020 Jul 3:1-19. Epub 2020 Jul 3.

University of Coimbra, Coimbra Institute for Biomedical Imaging and Translational Research (CIBIT), Coimbra, Portugal.

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http://dx.doi.org/10.1080/09638288.2020.1783001DOI Listing
July 2020

Twin Pregnancies, Crown-rump Length and Birthweight Discordancy: The Influence of Chorionicity.

Rev Bras Ginecol Obstet 2020 Sep 19;42(9):529-534. Epub 2020 Jun 19.

Obstetrics & Gynecology Department, São João Hospital & University Centre, Porto, Portugal.

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http://dx.doi.org/10.1055/s-0040-1712128DOI Listing
September 2020

Use of antioxidant could ameliorate the negative impact of etoposide on human sperm DNA during chemotherapy.

Reprod Biomed Online 2020 Jun 15;40(6):856-866. Epub 2020 Feb 15.

Laboratory of Cell Biology, Department of Microscopy, Institute of Biomedical Sciences Abel Salazar (ICBAS), University of Porto (UP), Porto, Portugal; Unit for Multidisciplinary Research in Biomedicine (UMIB), University of Porto, Porto, Portugal.

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http://dx.doi.org/10.1016/j.rbmo.2020.01.029DOI Listing
June 2020

The Impact of Deep Brain Stimulation on the Sexual Function of Patients With Parkinson's Disease.

Neurologist 2020 May;25(3):55-61

Neurology Department, Coimbra Hospital and University Centre.

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http://dx.doi.org/10.1097/NRL.0000000000000272DOI Listing
May 2020

Stereological study of organelle distribution in human oocytes at metaphase I.

Zygote 2020 Aug 14;28(4):308-317. Epub 2020 Apr 14.

Laboratory of Cell Biology, Department of Microscopy, Institute of Biomedical Sciences Abel Salazar (ICBAS), University of Porto (UP), Rua Jorge Viterbo Ferreira, 228, 4050-313Porto, Portugal.

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http://dx.doi.org/10.1017/S0967199420000131DOI Listing
August 2020

Late-onset hypogonadism and lifestyle-related metabolic disorders.

Andrology 2020 Jan 28. Epub 2020 Jan 28.

Department of Microscopy, Laboratory of Cell Biology, and Unit for Multidisciplinary Research in Biomedicine (UMIB), Institute of Biomedical Sciences Abel Salazar (ICBAS), University of Porto, Porto, Portugal.

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http://dx.doi.org/10.1111/andr.12765DOI Listing
January 2020

Bioinformatics and Computational Tools for Next-Generation Sequencing Analysis in Clinical Genetics.

J Clin Med 2020 Jan 3;9(1). Epub 2020 Jan 3.

Laboratory of Cell Biology, Department of Microscopy, Institute of Biomedical Sciences Abel Salazar (ICBAS), University of Porto (UP), 4050-313 Porto, Portugal.

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http://dx.doi.org/10.3390/jcm9010132DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7019349PMC
January 2020

Unveiling the genetic etiology of primary ciliary dyskinesia: When standard genetic approach is not enough.

Adv Med Sci 2020 Mar 10;65(1):1-11. Epub 2019 Dec 10.

Institute of Biomedical Sciences Abel Salazar, University of Porto, Porto, Portugal; Multidisciplinary Unit for Biomedical Research, Institute of Biomedical Sciences Abel Salazar, University of Porto, Porto, Portugal. Electronic address:

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http://dx.doi.org/10.1016/j.advms.2019.10.003DOI Listing
March 2020

Clinical and Genetic Analysis of Children with Kartagener Syndrome.

Cells 2019 08 15;8(8). Epub 2019 Aug 15.

Laboratory of Cell Biology, Department of Microscopy, Institute of Biomedical Sciences Abel Salazar (ICBAS), University of Porto (UP), Rua Jorge Viterbo Ferreira, 228, 4050-313 Porto, Portugal.

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http://dx.doi.org/10.3390/cells8080900DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6721662PMC
August 2019

mTOR Signaling Pathway Regulates Sperm Quality in Older Men.

Cells 2019 06 21;8(6). Epub 2019 Jun 21.

Laboratory of Signal Transduction, Department of Medical Sciences, Institute of Biomedicine-iBiMED, University of Aveiro, 3810-193 Aveiro, Portugal.

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http://dx.doi.org/10.3390/cells8060629DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6627782PMC
June 2019

L-Theanine promotes cultured human Sertoli cells proliferation and modulates glucose metabolism.

Eur J Nutr 2019 Oct 10;58(7):2961-2970. Epub 2019 Jun 10.

Department of Microscopy, Laboratory of Cell Biology and Unit for Multidisciplinary Research in Biomedicine, Institute of Biomedical Sciences Abel Salazar (ICBAS), University of Porto, 4050-313, Porto, Portugal.

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http://dx.doi.org/10.1007/s00394-019-01999-2DOI Listing
October 2019

pH and male fertility: making sense on pH homeodynamics throughout the male reproductive tract.

Cell Mol Life Sci 2019 Oct 4;76(19):3783-3800. Epub 2019 Jun 4.

Laboratory of Cell Biology, Department of Microscopy, Institute of Biomedical Sciences Abel Salazar and Unit for Multidisciplinary Research in Biomedicine, University of Porto, Porto, Portugal.

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http://link.springer.com/10.1007/s00018-019-03170-w
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http://dx.doi.org/10.1007/s00018-019-03170-wDOI Listing
October 2019

Dopamine dysregulation syndrome induced by proxy.

BMJ Case Rep 2019 May 16;12(5). Epub 2019 May 16.

Neurology Department, Centro Hospitalar e Universitário de Coimbra, Portugal.

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http://casereports.bmj.com/lookup/doi/10.1136/bcr-2018-22849
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http://dx.doi.org/10.1136/bcr-2018-228495DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6536167PMC
May 2019

Molecular aspects of collagenolysis associated with stress urinary incontinence in women with urethral hypermobility vs intrinsic sphincter deficiency.

Neurourol Urodyn 2019 08 16;38(6):1533-1539. Epub 2019 May 16.

Department of Microscopy, Laboratory of Cell Biology, Institute of Biomedical Sciences Abel Salazar (ICBAS) and Unit for Multidisciplinary Research in Biomedicine (UMIB), University of Porto, Porto, Portugal.

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http://dx.doi.org/10.1002/nau.24026DOI Listing
August 2019

Protective role of N-acetylcysteine (NAC) on human sperm exposed to etoposide.

Basic Clin Androl 2019 7;29. Epub 2019 Feb 7.

1Laboratory of Cell Biology, Department of Microscopy, Institute of Biomedical Sciences Abel Salazar (ICBAS), University of Porto (UP), Rua Jorge Viterbo Ferreira, 228, 4050-313 Porto, Portugal.

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http://dx.doi.org/10.1186/s12610-018-0082-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6366041PMC
February 2019

Impulsivity across reactive, proactive and cognitive domains in Parkinson's disease on dopaminergic medication: Evidence for multiple domain impairment.

PLoS One 2019 13;14(2):e0210880. Epub 2019 Feb 13.

Coimbra Institute for Biomedical Imaging and Translational Research (CiBit), ICNAS-Institute for Nuclear Sciences Applied to Health, Brain Imaging Network of Portugal, Coimbra, Portugal.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0210880PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6373905PMC
October 2019

Carbonic anhydrases are involved in mitochondrial biogenesis and control the production of lactate by human Sertoli cells.

FEBS J 2019 04 18;286(7):1393-1406. Epub 2019 Feb 18.

Department of Microscopy, Laboratory of Cell Biology, Institute of Biomedical Sciences, Abel Salazar (ICBAS) and Multidisciplinary Unit for Biomedical Research (UMIB), University of Porto, Portugal.

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http://dx.doi.org/10.1111/febs.14779DOI Listing
April 2019

Structural and molecular analysis of the cancer prostate cell line PC3: Oocyte zona pellucida glycoproteins.

Tissue Cell 2018 Dec 3;55:91-106. Epub 2018 Nov 3.

Laboratory of Cell Biology, Department of Microscopy, Institute of Biomedical Sciences Abel Salazar (ICBAS), University of Porto (UP), Rua Jorge Viterbo Ferreira, 228, 4050-313, Porto, Portugal; Multidisciplinary Unit for Biomedical Research (UMIB), University of Porto, Rua Jorge Viterbo Ferreira, 228, 4050-313, Porto, Portugal. Electronic address:

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http://dx.doi.org/10.1016/j.tice.2018.11.001DOI Listing
December 2018

Insights into leptin signaling and male reproductive health: the missing link between overweight and subfertility?

Biochem J 2018 11 20;475(22):3535-3560. Epub 2018 Nov 20.

Department of Microscopy, Laboratory of Cell Biology, Institute of Biomedical Sciences Abel Salazar (ICBAS), University of Porto, Porto, Portugal

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http://dx.doi.org/10.1042/BCJ20180631DOI Listing
November 2018

Metabolic dynamics of human Sertoli cells are differentially modulated by physiological and pharmacological concentrations of GLP-1.

Toxicol Appl Pharmacol 2019 01 6;362:1-8. Epub 2018 Oct 6.

Department of Microscopy, Laboratory of Cell Biology, Abel Salazar Institute of Biomedical Sciences (ICBAS), University of Porto, Porto, Portugal; Unit for Multidisciplinary Research in Biomedicine, Abel Salazar Institute of Biomedical Sciences (UMIB-ICBAS), University of Porto, Porto, Portugal. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S0041008X183046
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http://dx.doi.org/10.1016/j.taap.2018.10.009DOI Listing
January 2019

Shedding light into the relevance of telomeres in human reproduction and male factor infertility†.

Biol Reprod 2019 02;100(2):318-330

Laboratory of Cell Biology, Department of Microscopy, and Multidisciplinary Unit for Biomedical Research (UMIB), Institute of Biomedical Sciences Abel Salazar (ICBAS), University of Porto, Porto, Portugal.

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https://academic.oup.com/biolreprod/advance-article/doi/10.1
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http://dx.doi.org/10.1093/biolre/ioy215DOI Listing
February 2019

Senescence and declining reproductive potential: Insight into molecular mechanisms through testicular metabolomics.

Biochim Biophys Acta Mol Basis Dis 2018 10 29;1864(10):3388-3396. Epub 2018 Jul 29.

Laboratory of Cell Biology and Unit for Multidisciplinary Research in Biomedicine (UMIB), Department of Microscopy, Institute of Biomedical Sciences Abel Salazar (ICBAS), University of Porto, Porto, Portugal; i3S, Instituto de Investigação e Inovação em Saúde, Universidade do Porto, Porto, Portugal; Centre for Reproductive Genetics Prof. Alberto Barros, Porto, Portugal. Electronic address:

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http://dx.doi.org/10.1016/j.bbadis.2018.07.028DOI Listing
October 2018

Decal-Lenses: Interactive Lenses on Surfaces for Multivariate Visualization.

IEEE Trans Vis Comput Graph 2019 Aug 26;25(8):2568-2582. Epub 2018 Jun 26.

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http://dx.doi.org/10.1109/TVCG.2018.2850781DOI Listing
August 2019

Molecular Mechanisms and Signaling Pathways Involved in the Nutritional Support of Spermatogenesis by Sertoli Cells.

Methods Mol Biol 2018 ;1748:129-155

Department of Microscopy, Laboratory of Cell Biology and Unit for Multidisciplinary Research in Biomedicine (UMIB), Institute of Biomedical Sciences Abel Salazar (ICBAS), University of Porto, Porto, Portugal.

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http://dx.doi.org/10.1007/978-1-4939-7698-0_11DOI Listing
February 2019

Apathy Profile in Parkinson's and Huntington's Disease: A Comparative Cross-Sectional Study.

Eur Neurol 2018 13;79(1-2):13-20. Epub 2017 Nov 13.

Coimbra Hospital and University Centre, Neurology Department, Coimbra, Portugal.

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http://dx.doi.org/10.1159/000481981DOI Listing
January 2019

Clinical outcomes after preimplantation genetic diagnosis of patients with Corino de Andrade disease (familial amyloid polyneuropathy).

Reprod Biomed Online 2018 Jan 12;36(1):39-46. Epub 2017 Oct 12.

Centre for Reproductive Genetics A. Barros (CGR), Porto, Portugal; Department of Genetics, Faculty of Medicine, Institute of Health Research and Innovation (I3S), University of Porto, Porto, Portugal.

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http://dx.doi.org/10.1016/j.rbmo.2017.09.010DOI Listing
January 2018

Exonization of an Intronic LINE-1 Element Causing Becker Muscular Dystrophy as a Novel Mutational Mechanism in Dystrophin Gene.

Genes (Basel) 2017 Oct 3;8(10). Epub 2017 Oct 3.

Unidade de Genética Molecular, Centro de Genética Médica Dr. Jacinto Magalhães, Centro Hospitalar do Porto, 4050-106 Porto, Portugal.

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http://dx.doi.org/10.3390/genes8100253DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5664103PMC
October 2017

Glycerol and testicular activity: the good, the bad and the ugly.

Mol Hum Reprod 2017 11;23(11):725-737

Department of Microscopy, Laboratory of Cell Biology, and Unit for Multidisciplinary Research in Biomedicine (UMIB), Institute of Biomedical Sciences Abel Salazar (ICBAS), University of Porto, Porto, Portugal.

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http://dx.doi.org/10.1093/molehr/gax049DOI Listing
November 2017

Corino de Andrade disease: mechanisms and impact on reproduction.

JBRA Assist Reprod 2017 06 1;21(2):105-114. Epub 2017 Jun 1.

Laboratory of Cell Biology, Department of Microscopy, Institute of Biomedical Sciences Abel Salazar (ICBAS), University of Porto, Portugal.

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http://dx.doi.org/10.5935/1518-0557.20170025DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5473703PMC
June 2017

Body mass index is associated with region-dependent metabolic reprogramming of adipose tissue.

BBA Clin 2017 Dec 11;8:1-6. Epub 2017 May 11.

Multidisciplinary Unit for Biomedical Research, UMIB-FCT, Institute of Biomedical Sciences Abel Salazar (ICBAS), University of Porto, Portugal.

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http://dx.doi.org/10.1016/j.bbacli.2017.05.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5440253PMC
December 2017

Fertility and Sperm Quality in the Aging Male.

Curr Pharm Des 2017 Nov;23(30):4429-4437

Department of Microscopy, Laboratory of Cell Biology, Institute of Biomedical Sciences Abel Salazar (ICBAS), University of Porto, Porto, Portugal.

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http://dx.doi.org/10.2174/1381612823666170503150313DOI Listing
November 2017

Implications of epigallocatechin-3-gallate in cultured human Sertoli cells glycolytic and oxidative profile.

Toxicol In Vitro 2017 Jun 18;41:214-222. Epub 2017 Mar 18.

Department of Microscopy, Laboratory of Cell Biology, Institute of Biomedical Sciences Abel Salazar, Unit for Multidisciplinary Research in Biomedicine, University of Porto, 4050-313 Porto, Portugal; Department of Genetics, Faculty of Medicine, University of Porto, 4050-313 Porto, Portugal; i3S- Instituto de Investigação e Inovação em Saúde, Universidade do Porto, 4200-135 Porto, Portugal. Electronic address:

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http://dx.doi.org/10.1016/j.tiv.2017.03.006DOI Listing
June 2017

Obesity, energy balance and spermatogenesis.

Reproduction 2017 06 10;153(6):R173-R185. Epub 2017 Mar 10.

Unit for Multidisciplinary Research in Biomedicine (UMIB)Institute of Biomedical Sciences Abel Salazar (ICBAS), University of Porto, Porto, Portugal

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http://dx.doi.org/10.1530/REP-17-0018DOI Listing
June 2017

Mammalian target of rapamycin (mTOR): a central regulator of male fertility?

Crit Rev Biochem Mol Biol 2017 06 26;52(3):235-253. Epub 2017 Jan 26.

a Laboratory of Cell Biology, Department of Microscopy and Unit for Multidisciplinary Research in Biomedicine (UMIB), Institute of Biomedical Sciences Abel Salazar (ICBAS), University of Porto , Porto , Portugal.

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http://dx.doi.org/10.1080/10409238.2017.1279120DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5499698PMC
June 2017

Transcranial Sonography and DaTSCAN in Early Stage Parkinson's Disease and Essential Tremor.

Eur Neurol 2016 18;76(5-6):252-255. Epub 2016 Oct 18.

Department of Neurology, Centro Hospitalar e Universitário de Coimbra, University of Coimbra, Coimbra, Portugal.

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http://dx.doi.org/10.1159/000452216DOI Listing
September 2017

Predictors of first-line treatment persistence in a Portuguese cohort of relapsing-remitting multiple sclerosis.

J Clin Neurosci 2016 Nov 16;33:73-78. Epub 2016 Aug 16.

Neurology Department, Centro Hospitalar e Universitário de Coimbra, Praceta Prof. Mota Pinto, 3000-075 Coimbra, Portugal.

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http://dx.doi.org/10.1016/j.jocn.2015.12.044DOI Listing
November 2016

Ultrastructural and cytogenetic analyses of mature human oocyte dysmorphisms with respect to clinical outcomes.

J Assist Reprod Genet 2016 Aug 24;33(8):1041-57. Epub 2016 May 24.

Centre for Reproductive Genetics Alberto Barros (CGR), Av. do Bessa, 240, 1° Dto. Frente, 4100-009, Porto, Portugal.

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http://dx.doi.org/10.1007/s10815-016-0739-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4974231PMC
August 2016

Substantia nigra hyperechogenicity does not correlate with motor features in Parkinson's disease.

J Neurol Sci 2016 May 2;364:9-11. Epub 2016 Mar 2.

Neurology Department, Centro Hospitalar e Universitário de Coimbra, Coimbra, Portugal; Faculdade de Medicina, Universidade de Coimbra, Coimbra, Portugal.

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http://dx.doi.org/10.1016/j.jns.2016.03.002DOI Listing
May 2016

Sirtuins: Novel Players in Male Reproductive Health.

Curr Med Chem 2016 ;23(11):1084-99

Department of Microscopy, Laboratory of Cell Biology, Institute of Biomedical Sciences Abel Salazar (ICBAS), Rua de Jorge Viterbo Ferreira 228, 4050-313 Porto, Portugal.

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http://dx.doi.org/10.2174/0929867323666160229114248DOI Listing
February 2017

Emerging Potential of Natural Products as an Alternative Strategy to Pharmacological Agents Used Against Metabolic Disorders.

Curr Drug Metab 2016 ;17(6):582-97

Department of Microscopy, Laboratory of Cell Biology, Institute of Biomedical Sciences Abel Salazar (ICBAS), Rua de Jorge Viterbo Ferreira nº228, 4050-313 Porto, Portugal.

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http://dx.doi.org/10.2174/1389200217666160229113629DOI Listing
February 2017

Y-chromosome microdeletions in nonobstructive azoospermia and severe oligozoospermia.

Asian J Androl 2017 May-Jun;19(3):338-345

Department of Microscopy, Laboratory of Cell Biology, Institute of Biomedical Sciences Abel Salazar, University of Porto (ICBAS-UP), Rua Jorge Viterbo Ferreira, 228, 4050-313 Porto, Portugal and Multidisciplinary Unit for Biomedical Research, ICBAS-UP, Portugal.

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http://dx.doi.org/10.4103/1008-682X.172827DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5427791PMC
March 2018

Estradiol modulates Na(+) -dependent HCO3 (-) transporters altering intracellular pH and ion transport in human Sertoli cells: A role on male fertility?

Biol Cell 2016 Jul 9;108(7):179-88. Epub 2016 Mar 9.

Department of Microscopy, Laboratory of Cell Biology, Institute of Biomedical Sciences Abel Salazar (ICBAS) and Unit for Multidisciplinary Research in Biomedicine (UMIB), University of Porto, Porto, Portugal.

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http://dx.doi.org/10.1111/boc.201500094DOI Listing
July 2016

New massive parallel sequencing approach improves the genetic characterization of congenital myopathies.

J Hum Genet 2016 Jun 4;61(6):497-505. Epub 2016 Feb 4.

Unidade Multidisciplinar de Investigação Biomédica (UMIB), Instituto de Ciências Biomédicas Abel Salazar (ICBAS), Universidade do Porto, Porto, Portugal.

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http://dx.doi.org/10.1038/jhg.2016.2DOI Listing
June 2016

First transplantation of cryopreserved ovarian tissue in Portugal, stored for 10 years: an unexpected indication.

Reprod Biomed Online 2016 Mar 24;32(3):334-6. Epub 2015 Dec 24.

Unit of Reproductive Medicine, Department of Gynecology and Obstetrics, Hospital Center São João, Alameda Prof. Hernâni Monteiro, 4200-319 Porto, Portugal.

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http://dx.doi.org/10.1016/j.rbmo.2015.12.002DOI Listing
March 2016

Are Polyphenols Strong Dietary Agents Against Neurotoxicity and Neurodegeneration?

Neurotox Res 2016 10 8;30(3):345-66. Epub 2016 Jan 8.

CICS-UBI, Health Sciences Research Centre, Faculty of Health Sciences, University of Beira Interior, Av. Infante D. Henrique, 6200-506, Covilhã, Portugal.

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http://dx.doi.org/10.1007/s12640-015-9590-4DOI Listing
October 2016

New insights on hormones and factors that modulate Sertoli cell metabolism.

Histol Histopathol 2016 May 29;31(5):499-513. Epub 2015 Dec 29.

Department of Microscopy, Laboratory of Cell Biology and Unit for Multidisciplinary Research in Biomedicine, Abel Salazar Institute of Biomedical Sciences, University of Porto - UMIB/ICBAS/UP, Porto and I3S - Institute for Innovation and Health Research, University of Porto, Porto, Portugal.

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http://dx.doi.org/10.14670/HH-11-717DOI Listing
May 2016

Mammalian target of rapamycin controls glucose consumption and redox balance in human Sertoli cells.

Fertil Steril 2016 Mar 14;105(3):825-833.e3. Epub 2015 Dec 14.

CICS-UBI - Health Sciences Research Centre, University of Beira Interior, Covilhã. Electronic address:

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http://dx.doi.org/10.1016/j.fertnstert.2015.11.032DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4845725PMC
March 2016

Major regulatory mechanisms involved in sperm motility.

Asian J Androl 2017 Jan-Feb;19(1):5-14

Department of Microscopy, Laboratory of Cell Biology, Institute of Biomedical Sciences Abel Salazar, University of Porto (ICBAS-UP), Rua Jorge Viterbo Ferreira, 228, 4050-313 Porto, Portugal and Multidisciplinary Unit for Biomedical Research-UMIB, ICBAS-UP, Portugal.

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http://dx.doi.org/10.4103/1008-682X.167716DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5227674PMC
February 2017

Testicular lactate content is compromised in men with Klinefelter Syndrome.

Mol Reprod Dev 2016 Mar 6;83(3):208-16. Epub 2016 Jan 6.

Department of Microscopy, Laboratory of Cell Biology, Institute of Biomedical Sciences Abel Salazar (ICBAS) and Unit for Multidisciplinary Research in Biomedicine (UMIB), University of Porto, Porto, Portugal.

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http://dx.doi.org/10.1002/mrd.22608DOI Listing
March 2016

Male fertility and obesity: are ghrelin, leptin and glucagon-like peptide-1 pharmacologically relevant?

Curr Pharm Des 2016 ;22(7):783-91

Health Sciences Research Centre, Faculty of Health Sciences, University of Beira Interior, Av. Infante D. Henrique, 6201-506 Covilhã, Portugal.

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http://dx.doi.org/10.2174/1381612822666151209151550DOI Listing
October 2016

[Urinary Tuberculosis: Serious Complications May Occur when Diagnosis is Delayed].

Acta Med Port 2015 May-Jun;28(3):382-5. Epub 2015 Jun 30.

Serviço de Urologia. Centro Hospitalar de Vila Nova de Gaia / Espinho. Vila Nova de Gaia. Portugal.

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August 2017

Sperm DNA fragmentation is related to sperm morphological staining patterns.

Reprod Biomed Online 2015 Oct 7;31(4):506-15. Epub 2015 Jul 7.

Department of Microscopy, Laboratory of Cell Biology, Unit for Multidisciplinary Research in Biomedicine (UMIB), Institute of Biomedical Sciences Abel Salazar (ICBAS), University of Porto (UP), Porto, Portugal.

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http://dx.doi.org/10.1016/j.rbmo.2015.06.019DOI Listing
October 2015

Is Magnetic-Activated Cell Sorting an Efficient Technique in Reducing Human Sperm DNA Fragmentation?

Microsc Microanal 2015 Aug;21 Suppl 5:63-4

1Department of Microscopy,Laboratory of Cell Biology,Institute of Biomedical Sciences Abel Salazar,University of Porto,Multidisciplinary Unit for Biomedical Research (UMIB),Rua Jorge Viterbo Ferreira,228,4050-313 Porto,Portugal.

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http://dx.doi.org/10.1017/S1431927615014129DOI Listing
August 2015

A stereological study on organelle distribution in human oocytes at prophase I.

Zygote 2016 Jun 14;24(3):346-54. Epub 2015 Jul 14.

Department of Microscopy,Laboratory of Cell Biology,Institute of Biomedical Sciences Abel Salazar (ICBAS),University of Porto (UP),Rua Jorge Viterbo Ferreira,228,4050-313 Porto,Portugal.

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http://dx.doi.org/10.1017/S0967199415000258DOI Listing
June 2016

Antidiabetic Drugs: Mechanisms of Action and Potential Outcomes on Cellular Metabolism.

Curr Pharm Des 2015 ;21(25):3606-20

CICS-UBI, Health Sciences Research Centre, University of Beira Interior, Av. Infante D. Henrique, 6201-506 Covilhã, Portugal.

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http://dx.doi.org/10.2174/1381612821666150710145753DOI Listing
June 2016

Impact of Metformin on Male Reproduction.

Curr Pharm Des 2015 ;21(25):3621-33

Department of Microscopy, Laboratory of Cell Biology, ICBAS-UP, UMIB, Rua Jorge Viterbo Ferreira 228, Building 1, Floor 2, Room 03, 4050-313 Porto, Portugal.

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http://dx.doi.org/10.2174/1381612821666150710150041DOI Listing
June 2016

Dehydroepiandrosterone and 7-oxo-dehydroepiandrosterone in male reproductive health: Implications of differential regulation of human Sertoli cells metabolic profile.

J Steroid Biochem Mol Biol 2015 Nov 29;154:1-11. Epub 2015 Jun 29.

CICS-UBI-Health Sciences Research Centre, University of Beira Interior, 6200-506 Covilhã, Portugal; Department of Microscopy, Laboratory of Cell Biology, Institute of Biomedical Sciences Abel Salazar (ICBAS) and Unit for Multidisciplinary Research in Biomedicine (UMIB), University of Porto, 4050-313 Porto, Portugal. Electronic address:

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http://dx.doi.org/10.1016/j.jsbmb.2015.06.004DOI Listing
November 2015

Ovarian hyperstimulation syndrome: a clinical report on 4894 consecutive ART treatment cycles.

Reprod Biol Endocrinol 2015 Jun 23;13:66. Epub 2015 Jun 23.

Centre for Reproductive Genetics Alberto Barros, Av. do Bessa, 240, 1° Dto. Frente, 4100-012, Porto, Portugal.

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http://dx.doi.org/10.1186/s12958-015-0067-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4477314PMC
June 2015

Estrogenic regulation of bicarbonate transporters from SLC4 family in rat Sertoli cells.

Mol Cell Biochem 2015 Oct 23;408(1-2):47-54. Epub 2015 Jun 23.

Laboratory of Cell Biology, Department of Microscopy, Institute of Biomedical Sciences Abel Salazar (ICBAS), University of Porto, Porto, Portugal.

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http://dx.doi.org/10.1007/s11010-015-2481-4DOI Listing
October 2015

CFTR Regulation of Aquaporin-Mediated Water Transport: A Target in Male Fertility.

Curr Drug Targets 2015 ;16(9):993-1006

Instituto de Ciências Biomédicas Abel Salazar da Universidade do Porto, Departamento de Microscopia, Rua de Jorge Viterbo Ferreira no. 228, 4050-313 Porto, Portugal.

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http://dx.doi.org/10.2174/1573399811666150615144108DOI Listing
June 2016

Leptin modulates human Sertoli cells acetate production and glycolytic profile: a novel mechanism of obesity-induced male infertility?

Biochim Biophys Acta 2015 Sep 10;1852(9):1824-32. Epub 2015 Jun 10.

Health Sciences Research Centre (CICS-UBI), University of Beira Interior, Covilhã, Portugal; Department of Life Sciences, Faculty of Sciences and Technology and Center for Neurosciences and Cell Biology (CNC), University of Coimbra, Coimbra, Portugal. Electronic address:

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http://dx.doi.org/10.1016/j.bbadis.2015.06.005DOI Listing
September 2015

Metabolic fingerprints in testicular biopsies from type 1 diabetic patients.

Cell Tissue Res 2015 Nov 9;362(2):431-40. Epub 2015 Jun 9.

CICS - UBI - Health Sciences Research Centre, University of Beira Interior, 6201-506, Covilhã, Portugal.

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http://dx.doi.org/10.1007/s00441-015-2217-5DOI Listing
November 2015

Mutation analysis in patients with total sperm immotility.

J Assist Reprod Genet 2015 Jun 16;32(6):893-902. Epub 2015 Apr 16.

Laboratory of Cell Biology, Department of Microscopy, Institute of Biomedical Sciences Abel Salazar (ICBAS), University of Porto (UP), Rua Jorge Viterbo Ferreira, 228, 4050-313, Porto, Portugal.

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http://dx.doi.org/10.1007/s10815-015-0474-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4491072PMC
June 2015

The role of estrogens and estrogen receptor signaling pathways in cancer and infertility: the case of schistosomes.

Trends Parasitol 2015 Jun 30;31(6):246-50. Epub 2015 Mar 30.

Department of Microscopy, Laboratory of Cell Biology, Institute of Biomedical Sciences Abel Salazar (ICBAS), Multidisciplinary Unit for Biomedical Research-UMIB, University of Porto, Porto, Portugal.

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http://dx.doi.org/10.1016/j.pt.2015.03.005DOI Listing
June 2015

Epilepsia partialis continua of the abdominal muscles due to cerebrovascular disease.

Epileptic Disord 2015 Mar;17(1):72-6; quiz 76

Department of Neurology, Coimbra University Hospital Center, Coimbra, Portugal.

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http://dx.doi.org/10.1684/epd.2015.0732DOI Listing
March 2015

New splicing mutation in the choline kinase beta (CHKB) gene causing a muscular dystrophy detected by whole-exome sequencing.

J Hum Genet 2015 Jun 5;60(6):305-12. Epub 2015 Mar 5.

1] Departamento de Microscopia, Laboratório de Biologia Celular, Instituto de Ciências Biomédicas Abel Salazar (ICBAS), Universidade do Porto, Porto, Portugal [2] Unidade Multidisciplinar de Investigação Biomédica (UMIB), Instituto de Ciências Biomédicas Abel Salazar (ICBAS), Universidade do Porto, Porto, Portugal [3] Centro de Genética da Reprodução Professor Alberto Barros, Porto, Portugal.

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http://dx.doi.org/10.1038/jhg.2015.20DOI Listing
June 2015

Sertoli cell as a model in male reproductive toxicology: Advantages and disadvantages.

J Appl Toxicol 2015 Aug 18;35(8):870-83. Epub 2015 Feb 18.

CICS - UBI - Health Sciences Research Centre, University of Beira Interior, Covilhã, Portugal.

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http://dx.doi.org/10.1002/jat.3122DOI Listing
August 2015

Ultrastructural analysis of five patients with total sperm immotility.

Zygote 2015 Dec 20;23(6):900-7. Epub 2015 Jan 20.

Department of Microscopy,Laboratory of Cell Biology,Muldisciplinary Unit for Biomedical Research-UMIB,Institute of Biomedical Sciences Abel Salazar (ICBAS),University of Porto,Rua Jorge Viterbo Ferreira,228,4050-313 Porto,Portugal.

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http://dx.doi.org/10.1017/S0967199414000616DOI Listing
December 2015

Dose-dependent effects of caffeine in human Sertoli cells metabolism and oxidative profile: relevance for male fertility.

Toxicology 2015 Feb 5;328:12-20. Epub 2014 Dec 5.

CICS - UBI - Health Sciences Research Centre, University of Beira Interior, 6201-506 Covilhã, Portugal; Department of Microscopy, Laboratory of Cell Biology, Institute of Biomedical Sciences Abel Salazar (ICBAS) and Unit for Multidisciplinary Research in Biomedicine (UMIB), University of Porto, Portugal. Electronic address:

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http://dx.doi.org/10.1016/j.tox.2014.12.003DOI Listing
February 2015

The mutational spectrum of WT1 in male infertility.

J Urol 2015 May 11;193(5):1709-15. Epub 2014 Nov 11.

Institute of Molecular Pathology and Immunology, University of Porto, Porto, Portugal. Electronic address:

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http://dx.doi.org/10.1016/j.juro.2014.11.004DOI Listing
May 2015

New biomarkers to fight urogenital schistosomiasis: a major neglected tropical disease.

Biomark Med 2014 ;8(9):1061-3

Department of Health Promotion & Chronic Diseases, INSA-National Institute of Health Dr Ricardo Jorge, Porto, Portugal.

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http://dx.doi.org/10.2217/bmm.14.68DOI Listing
July 2015

DNA fragmentation in human sperm after magnetic-activated cell sorting.

J Assist Reprod Genet 2015 Jan 6;32(1):147-54. Epub 2014 Nov 6.

Department of Microscopy, Laboratory of Cell Biology, Institute of Biomedical Sciences Abel Salazar (ICBAS), University of Porto (UP), Multidisciplinary Unit for Biomedical Research (UMIB), Rua Jorge Viterbo Ferreira, 228, 4050-313, Porto, Portugal.

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http://dx.doi.org/10.1007/s10815-014-0370-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4294881PMC
January 2015

Aquaporin-9 is expressed in rat Sertoli cells and interacts with the cystic fibrosis transmembrane conductance regulator.

IUBMB Life 2014 Sep 1;66(9):639-44. Epub 2014 Oct 1.

CICS-UBI, Health Sciences Research Centre, University of Beira Interior, Covilhã, Portugal; Department of Microscopy, Laboratory of Cell Biology, Multidisciplinary Unit for Biomedical Research, UMIB-FCT, Institute of Biomedical Sciences Abel Salazar (ICBAS), University of Porto, Portugal.

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http://dx.doi.org/10.1002/iub.1312DOI Listing
September 2014

A novel Alu-mediated microdeletion at 11p13 removes WT1 in a patient with cryptorchidism and azoospermia.

Reprod Biomed Online 2014 Sep 16;29(3):388-91. Epub 2014 May 16.

Institute of Molecular Pathology and Immunology of the University of Porto (IPATIMUP), Porto, Portugal. Electronic address:

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http://dx.doi.org/10.1016/j.rbmo.2014.04.017DOI Listing
September 2014

Physiology of na+/h+ exchangers in the male reproductive tract: relevance for male fertility.

Biol Reprod 2014 Jul 29;91(1):11. Epub 2014 May 29.

CICS-UBI-Health Sciences Research Centre, University of Beira Interior, Covilhã, Portugal

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https://academic.oup.com/biolreprod/article-lookup/doi/10.10
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http://dx.doi.org/10.1095/biolreprod.114.118331DOI Listing
July 2014

Molecular cytogenetics of human single pronucleated zygotes.

Reprod Sci 2014 Dec 9;21(12):1472-82. Epub 2014 Apr 9.

Department of Microscopy, Laboratory of Cell Biology, Multidisciplinary Unit for Biomedical Research-UMIB, Institute of Biomedical Sciences Abel Salazar (ICBAS), University of Porto, Rua Jorge Viterbo Ferreira, Porto, Portugal

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http://dx.doi.org/10.1177/1933719114530185DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4231126PMC
December 2014

Expression pattern of G protein-coupled receptor 30 in human seminiferous tubular cells.

Gen Comp Endocrinol 2014 May 25;201:16-20. Epub 2014 Mar 25.

CICS-UBI - Health Sciences Research Centre, University of Beira Interior, Av. Infante D. Henrique, 6200-506 Covilhã, Portugal. Electronic address:

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http://dx.doi.org/10.1016/j.ygcen.2014.02.022DOI Listing
May 2014

Aquaporin-4 as a molecular partner of cystic fibrosis transmembrane conductance regulator in rat Sertoli cells.

Biochem Biophys Res Commun 2014 Apr 19;446(4):1017-21. Epub 2014 Mar 19.

CICS - UBI - Health Sciences Research Centre, University of Beira Interior, Covilhã, Portugal. Electronic address:

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http://dx.doi.org/10.1016/j.bbrc.2014.03.046DOI Listing
April 2014

Reviewing Large LAMA2 Deletions and Duplications in Congenital Muscular Dystrophy Patients.

J Neuromuscul Dis 2014;1(2):169-179

Departamento de Microscopia, Laboratório de Biologia Celular, Instituto de Ciências Biomédicas Abel Salazar (ICBAS), Universidade do Porto, Porto, Portugal.

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January 2014

"Omics" of human sperm: profiling protein phosphatases.

OMICS 2013 Sep 29;17(9):460-72. Epub 2013 Jul 29.

Centro de Biologia Celular, Secção Autónoma de Ciências da Saúde, Departamento de Biologia, Universidade de Aveiro, Aveiro, Portugal.

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http://dx.doi.org/10.1089/omi.2012.0119DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3760024PMC
September 2013

Expression of stem cell markers: OCT4, KIT, ITGA6, and ITGB1 in the male germinal epithelium.

Syst Biol Reprod Med 2013 Oct 13;59(5):233-43. Epub 2013 Jun 13.

Department of Microscopy, Laboratory of Cell Biology, Biomedical Research Multidisciplinary Unit (UMIB), Institute of Biomedical Sciences Abel Salazar (ICBAS) , University of Porto.

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http://dx.doi.org/10.3109/19396368.2013.804964DOI Listing
October 2013

[Ovarian hyperstimulation syndrome: experience of a reproductive medicine center 2005-2011].

Acta Med Port 2013 Jan-Feb;26(1):24-32. Epub 2013 Apr 24.

Departamento de Microscopia, Laboratório de Biologia Celular, Instituto de Ciências Biomédicas de Abel Salazar, Universidade do Porto, Porto, Portugal.

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April 2014

Caspase signalling pathways in human spermatogenesis.

J Assist Reprod Genet 2013 Apr 29;30(4):487-95. Epub 2013 Jan 29.

Department of Genetics, Faculty of Medicine, University of Porto, Porto, 4200-319, Portugal.

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http://dx.doi.org/10.1007/s10815-013-9938-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3644121PMC
April 2013

Immunohystochemical analysis of CFTR in normal and disrupted spermatogenesis.

Syst Biol Reprod Med 2013 Feb 18;59(1):53-9. Epub 2012 Sep 18.

Department of Microscopy, Laboratory of Cell Biology, UMIB, Institute of Biomedical Sciences Abel Salazar (ICBAS), University of Porto, Porto, Portugal.

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http://dx.doi.org/10.3109/19396368.2012.718851DOI Listing
February 2013

Genetic regulation on ex vivo differentiated natural killer cells from human umbilical cord blood CD34+ cells.

J Recept Signal Transduct Res 2012 Oct 4;32(5):238-49. Epub 2012 Jul 4.

Department of Genetics, Faculty of Medicine, University of Porto, Portugal.

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http://dx.doi.org/10.3109/10799893.2012.700716DOI Listing
October 2012

Pyruvate dehydrogenase complex: mRNA and protein expression patterns of E1α subunit genes in human spermatogenesis.

Gene 2012 Sep 29;506(1):173-8. Epub 2012 Jun 29.

Research Institute for Medicines and Pharmaceutical Sciences (iMed.UL), Faculty of Pharmacy, University of Lisbon, Portugal.

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http://dx.doi.org/10.1016/j.gene.2012.06.068DOI Listing
September 2012

Quantitative analysis of cellular proliferation and differentiation of the human seminiferous epithelium in vitro.

Reprod Sci 2012 Oct 27;19(10):1063-74. Epub 2012 Apr 27.

Department of Microscopy, Laboratory of Cell Biology, UMIB, Institute of Biomedical Sciences Abel Salazar (ICBAS), University of Porto, Porto, Portugal.

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http://dx.doi.org/10.1177/1933719112440746DOI Listing
October 2012

Does BDNF genotype influence creative output in bipolar I manic patients?

J Affect Disord 2012 Jul 6;139(2):181-6. Epub 2012 Apr 6.

Mood Disorders Unit GRUDA, Department and Institute of Psychiatry, School of Medicine, University of Sao Paulo (IPq HC-FMUSP), Brazil.

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http://dx.doi.org/10.1016/j.jad.2012.01.036DOI Listing
July 2012