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Publications Authored by Mario R Ehlers | PubFacts
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Novel Therapeutic Approaches Targeting the Renin-Angiotensin System and Associated Peptides in Hypertension and Heart Failure.

Pharmacol Rev 2019 10;71(4):539-570

Department of Integrative Biomedical Sciences, Institute of Infectious Disease and Molecular Medicine, University of Cape Town, South Africa (L.B.A., E.D.S.); Division of Pharmacology, Department of Internal Medicine, Erasmus Medical Center, Rotterdam, The Netherlands (A.H.J.D.); Attoquant Diagnostics, Vienna, Austria (M.P.); Institute of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow, United Kingdom (R.M.T.); Department of Cardiovascular Medicine, Mayo Clinic, Rochester, Minnesota (J.C.B.); Institut National de la Santé et de la Recherche Médicale, Paris, France (C.L.-C.); and Clinical Trials Group, Immune Tolerance Network, San Francisco, California (M.R.E.)

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http://dx.doi.org/10.1124/pr.118.017129DOI Listing
October 2019

Who let the dogs out? The ever-present threat of autoreactive T cells.

Authors:
Mario R Ehlers

Sci Immunol 2018 02 2;3(20). Epub 2018 Feb 2.

Immunology, Lilly Research Laboratories, Eli Lilly and Company, San Diego, CA 92121, USA.

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http://dx.doi.org/10.1126/sciimmunol.aar6602DOI Listing
February 2018

Anti-Gal and Anti-Neu5Gc Responses in Nonimmunosuppressed Patients After Treatment With Rabbit Antithymocyte Polyclonal IgGs.

Transplantation 2017 10;101(10):2501-2507

1 Centre de Recherche en Transplantation et Immunologie UMR 1064, INSERM, Université de Nantes, Nantes, France. 2 Institut de Transplantation Urologie Néphrologie (ITUN), CHU Nantes, Nantes, France. 3 Société d'Accélération du Transfert de Technologies Ouest Valorisation, Rennes, France. 4 Xenothera, Nantes, France. 5 Biomarker Discovery Research, Immune Tolerance Network, Bethesda, MD, USA. 6 IECM, Immuno-endocrinology, EA4644 Oniris, University of Nantes, USC1383 INRA, Oniris, Nantes, France. 7 Clinical Trials Group, Immune Tolerance Network, San Francisco, CA. 8 Division of Pediatric Endocrinology and Diabetes, University of California San Francisco, San Francisco, CA.

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http://dx.doi.org/10.1097/TP.0000000000001686DOI Listing
October 2017

Strategies for clinical trials in type 1 diabetes.

Authors:
Mario R Ehlers

J Autoimmun 2016 07 5;71:88-96. Epub 2016 Apr 5.

Clinical Trials Group, Immune Tolerance Network, 185 Berry Street, Suite 3515, San Francisco, CA, 94107, USA. Electronic address:

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http://dx.doi.org/10.1016/j.jaut.2016.03.008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4903883PMC
July 2016

Targeting memory T cells in type 1 diabetes.

Curr Diab Rep 2015 Nov;15(11):84

Translational Medicine, Immunology Development, Janssen R&D, Pharmaceutical Companies of Johnson & Johnson, Spring House, PA, 19477, USA.

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http://dx.doi.org/10.1007/s11892-015-0659-5DOI Listing
November 2015

Targeted immune interventions for type 1 diabetes: not as easy as it looks!

Curr Opin Endocrinol Diabetes Obes 2014 Aug;21(4):271-8

aIndiana University School of Medicine and Riley Hospital for Children at IU Health, Indianapolis, Indiana bImmune Tolerance Network, San Francisco, California, USA.

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http://dx.doi.org/10.1097/MED.0000000000000075DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4133939PMC
August 2014

Immune-directed therapy for type 1 diabetes at the clinical level: the Immune Tolerance Network (ITN) experience.

Rev Diabet Stud 2012 28;9(4):359-71. Epub 2012 Dec 28.

Clinical Trials Group, Immune Tolerance Network, San Francisco, CA, USA.

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http://dx.doi.org/10.1900/RDS.2012.9.359DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3740703PMC
January 2014

Antifibrotic peptide N-acetyl-Ser-Asp-Lys-Pro (Ac-SDKP): opportunities for angiotensin-converting enzyme inhibitor design.

Clin Exp Pharmacol Physiol 2013 Aug;40(8):535-41

Institute of Infectious Disease and Molecular Medicine, and Division of Medical Biochemistry, University of Cape Town, Cape Town, South Africa.

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http://dx.doi.org/10.1111/1440-1681.12062DOI Listing
August 2013

C domain-selective inhibition of angiotensin-converting enzyme.

J Renin Angiotensin Aldosterone Syst 2013 Jun;14(2):189-92

Institute of Infectious Disease and Molecular Medicine and Division of Medical Biochemistry, University of Cape Town, South Africa.

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http://dx.doi.org/10.1177/1470320313489206DOI Listing
June 2013

Shedding the load of hypertension: the proteolytic processing of angiotensin-converting enzyme.

S Afr Med J 2012 Mar 2;102(6):461-4. Epub 2012 Mar 2.

Immune Tolerance Network, USA.

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March 2012

Pacific biomarkers, inc.

Authors:
Mario R Ehlers

Biomark Med 2008 Jun;2(3):221-7

Pacific Biomarkers, Inc., 220 West Harrison Street, Seattle, WA 98119, USA.

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http://dx.doi.org/10.2217/17520363.2.3.221DOI Listing
June 2008

Safety issues associated with the use of angiotensin-converting enzyme inhibitors.

Authors:
Mario R Ehlers

Expert Opin Drug Saf 2006 Nov;5(6):739-40

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http://dx.doi.org/10.1517/14740338.5.6.739 DOI Listing
November 2006

Homologous substitution of ACE C-domain regions with N-domain sequences: effect on processing, shedding, and catalytic properties.

Biol Chem 2006 Aug;387(8):1043-51

Division of Medical Biochemistry and Institute of Infectious Disease and Molecular Medicine, University of Cape Town, Cape Town 7925, South Africa.

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http://dx.doi.org/10.1515/BC.2006.129DOI Listing
August 2006

Deletion of the cytoplasmic domain increases basal shedding of angiotensin-converting enzyme.

Biochem Biophys Res Commun 2004 Feb;314(4):971-5

Division of Medical Biochemistry, University of Cape Town Medical School, Observatory 7925, Cape Town, South Africa.

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http://dx.doi.org/10.1016/j.bbrc.2003.12.198DOI Listing
February 2004

Ace revisited: a new target for structure-based drug design.

Nat Rev Drug Discov 2003 Nov;2(11):891-902

Department of Biology and Biochemistry, University of Bath, Claverton Down, Bath BA2 7AY, UK.

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http://dx.doi.org/10.1038/nrd1227DOI Listing
November 2003

Deglycosylation, processing and crystallization of human testis angiotensin-converting enzyme.

Biochem J 2003 Apr;371(Pt 2):437-42

Division of Medical Biochemistry, Faculty of Health Sciences, University of Cape Town, Observatory 7925, South Africa.

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http://dx.doi.org/10.1042/BJ20021842DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1223310PMC
April 2003

Effect of glucagon-like peptide 1 (7-36 amide) on insulin-mediated glucose uptake in patients with type 1 diabetes.

Diabetes Care 2003 Mar;26(3):837-42

Department of Medicine, University of British Columbia, Vancouver, British Columbia, Canada.

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http://dx.doi.org/10.2337/diacare.26.3.837DOI Listing
March 2003

Mycosin-1, a subtilisin-like serine protease of Mycobacterium tuberculosis, is cell wall-associated and expressed during infection of macrophages.

BMC Microbiol 2002 Oct 7;2:30. Epub 2002 Oct 7.

Department of Medical Biochemistry, University of Cape Town Medical School, Observatory 7925, Cape Town, South Africa.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC131053PMC
October 2002

Defining the boundaries of the testis angiotensin I-converting enzyme ectodomain.

Biochem Biophys Res Commun 2002 Oct;297(5):1225-30

Division of Medical Biochemistry, University of Cape Town Medical School, Observatory 7925, Cape Town, South Africa.

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http://dx.doi.org/10.1016/s0006-291x(02)02324-0DOI Listing
October 2002