Publications by authors named "Mario L Suvà"

44Publications

The Glioma Stem Cell Model in the Era of Single-Cell Genomics.

Cancer Cell 2020 05;37(5):630-636

Department of Molecular Cell Biology, Weizmann Institute of Science, Rehovot 761001, Israel. Electronic address:

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http://dx.doi.org/10.1016/j.ccell.2020.04.001DOI Listing
May 2020

Tackling the Many Facets of Glioblastoma Heterogeneity.

Cell Stem Cell 2020 03;26(3):303-304

Department of Pathology and Center for Cancer Research, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA; Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA. Electronic address:

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http://dx.doi.org/10.1016/j.stem.2020.02.005DOI Listing
March 2020

Re-programing Chromatin with a Bifunctional LSD1/HDAC Inhibitor Induces Therapeutic Differentiation in DIPG.

Cancer Cell 2019 11 17;36(5):528-544.e10. Epub 2019 Oct 17.

Division of Newborn Medicine and Epigenetics Program, Department of Medicine, Boston Children's Hospital, Boston, MA 02115, USA; Department of Cell Biology, Harvard Medical School, Boston, MA 02115, USA. Electronic address:

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http://dx.doi.org/10.1016/j.ccell.2019.09.005DOI Listing
November 2019

Histone Variant and Cell Context Determine H3K27M Reprogramming of the Enhancer Landscape and Oncogenic State.

Mol Cell 2019 12 3;76(6):965-980.e12. Epub 2019 Oct 3.

Department of Neurology, Stanford University School of Medicine, Stanford, CA, USA; Stanford Institute for Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine, Stanford, CA, USA; Stanford Cancer Institute, Stanford University School of Medicine, Stanford, CA, USA; Department of Pediatrics, Stanford University School of Medicine, Stanford, CA, USA; Department of Neurosurgery, Stanford University School of Medicine, Stanford, CA, USA; Department of Pathology, Stanford University School of Medicine, Stanford, CA, USA. Electronic address:

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http://dx.doi.org/10.1016/j.molcel.2019.08.030DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7104854PMC
December 2019

Rapid Generation of Somatic Mouse Mosaics with Locus-Specific, Stably Integrated Transgenic Elements.

Cell 2019 09;179(1):251-267.e24

Board of Governors Regenerative Medicine Institute, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USA; Center for Neural Sciences in Medicine, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USA; Department of Biomedical Sciences, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USA; Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USA; Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA 90095, USA. Electronic address:

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http://dx.doi.org/10.1016/j.cell.2019.08.013DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6934691PMC
September 2019

An Integrative Model of Cellular States, Plasticity, and Genetics for Glioblastoma.

Cell 2019 08 18;178(4):835-849.e21. Epub 2019 Jul 18.

Department of Pathology and Center for Cancer Research, Massachusetts General Hospital and Harvard Medical School, Boston, MA, 02114, USA; Klarman Cell Observatory, Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA; Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA. Electronic address:

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http://dx.doi.org/10.1016/j.cell.2019.06.024DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6703186PMC
August 2019

Single-Cell RNA Sequencing in Cancer: Lessons Learned and Emerging Challenges.

Mol Cell 2019 07;75(1):7-12

Department of Molecular Cell Biology, Weizmann Institute of Science, Rehovot 761001, Israel. Electronic address:

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http://dx.doi.org/10.1016/j.molcel.2019.05.003DOI Listing
July 2019

A Public BCR Present in a Unique Dual-Receptor-Expressing Lymphocyte from Type 1 Diabetes Patients Encodes a Potent T Cell Autoantigen.

Cell 2019 05;177(6):1583-1599.e16

Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA; Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA. Electronic address:

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http://dx.doi.org/10.1016/j.cell.2019.05.007DOI Listing
May 2019

Single-Cell Transcriptomics Uncovers Glial Progenitor Diversity and Cell Fate Determinants during Development and Gliomagenesis.

Cell Stem Cell 2019 05 11;24(5):707-723.e8. Epub 2019 Apr 11.

Department of Pediatrics, Brain Tumor Center, Division of Experimental Hematology and Cancer Biology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229, USA; Key Laboratory of Birth Defects, Children's Hospital of Fudan University, Shanghai 201102, China. Electronic address:

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http://dx.doi.org/10.1016/j.stem.2019.03.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6669001PMC
May 2019

Non-inflammatory tumor microenvironment of diffuse intrinsic pontine glioma.

Acta Neuropathol Commun 2018 06 28;6(1):51. Epub 2018 Jun 28.

Department of Neurology, Stanford University, Stanford, CA, 94305, USA.

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http://dx.doi.org/10.1186/s40478-018-0553-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6022714PMC
June 2018

A Glial Signature and Wnt7 Signaling Regulate Glioma-Vascular Interactions and Tumor Microenvironment.

Cancer Cell 2018 05 19;33(5):874-889.e7. Epub 2018 Apr 19.

Department of Pediatrics, University of California San Francisco, San Francisco, CA 94143, USA; Eli and Edythe Broad Institute for Stem Cell Research and Regeneration Medicine, University of California San Francisco, San Francisco, CA 94143, USA; Department of Neurological Surgery and Brain Tumor Research Center, University of California San Francisco, San Francisco, CA 94143, USA; Department of Pediatrics, University of Cambridge and Wellcome Trust-MRC Stem Cell Institute, Hills Road, Cambridge CB2 0AN, UK. Electronic address:

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http://dx.doi.org/10.1016/j.ccell.2018.03.020DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6211172PMC
May 2018

Toward methylation-based classification of central nervous system tumors.

Neuro Oncol 2018 04;20(5):579-581

Department of Pathology and Center for Cancer Research, Massachusetts General Hospital, Broad Institute of Harvard and MIT, Boston, Massachusetts, USA.

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http://dx.doi.org/10.1093/neuonc/noy023DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5892157PMC
April 2018

Dissecting human gliomas by single-cell RNA sequencing.

Neuro Oncol 2018 01;20(1):37-43

Broad Institute of Harvard and MIT, Cambridge, Massachusetts.

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http://dx.doi.org/10.1093/neuonc/nox126DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5761500PMC
January 2018

Multiplexed RNAi therapy against brain tumor-initiating cells via lipopolymeric nanoparticle infusion delays glioblastoma progression.

Proc Natl Acad Sci U S A 2017 07 10;114(30):E6147-E6156. Epub 2017 Jul 10.

Department of Neurological Surgery, Brain Tumor Research Institute, The Feinberg School of Medicine, Northwestern University, Chicago, IL 60611;

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http://dx.doi.org/10.1073/pnas.1701911114DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5544292PMC
July 2017

Adaptive Chromatin Remodeling Drives Glioblastoma Stem Cell Plasticity and Drug Tolerance.

Cell Stem Cell 2017 02 15;20(2):233-246.e7. Epub 2016 Dec 15.

Department of Pathology and Center for Cancer Research, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA; Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA. Electronic address:

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http://dx.doi.org/10.1016/j.stem.2016.11.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5291795PMC
February 2017

The RNA Binding Protein IMP2 Preserves Glioblastoma Stem Cells by Preventing let-7 Target Gene Silencing.

Cell Rep 2016 05 12;15(8):1634-47. Epub 2016 May 12.

Division of Experimental Pathology, Institute of Pathology, CHUV, Faculty of Biology and Medicine, University of Lausanne, Rue du Bugnon 25, 1011 Lausanne, Switzerland. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2016.04.086DOI Listing
May 2016

Gliomas Genomics and Epigenomics: Arriving at the Start and Knowing It for the First Time.

Annu Rev Pathol 2016 05 2;11:497-521. Epub 2016 Mar 2.

Department of Pathology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02114; email:

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http://dx.doi.org/10.1146/annurev-pathol-012615-044208DOI Listing
May 2016

Insulator dysfunction and oncogene activation in IDH mutant gliomas.

Nature 2016 Jan 23;529(7584):110-4. Epub 2015 Dec 23.

Department of Pathology and Center for Cancer Research, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02114, USA.

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http://dx.doi.org/10.1038/nature16490DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4831574PMC
January 2016

Alternative lengthening of telomeres renders cancer cells hypersensitive to ATR inhibitors.

Science 2015 Jan;347(6219):273-7

Massachusetts General Hospital Cancer Center, Harvard Medical School, Charlestown, MA 02129, USA. Department of Pathology, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02115, USA.

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http://dx.doi.org/10.1126/science.1257216DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4358324PMC
January 2015

Single-cell RNA-seq highlights intratumoral heterogeneity in primary glioblastoma.

Science 2014 Jun 12;344(6190):1396-401. Epub 2014 Jun 12.

Department of Pathology and Center for Cancer Research, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA. Broad Institute of Harvard and Massachusetts Institute of Techonology (MIT), Cambridge, MA 02142, USA. Howard Hughes Medical Institute Chevy Chase, MD 20815, USA.

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http://www.sciencemag.org/cgi/doi/10.1126/science.1254257
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http://dx.doi.org/10.1126/science.1254257DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4123637PMC
June 2014

Reconstructing and reprogramming the tumor-propagating potential of glioblastoma stem-like cells.

Cell 2014 Apr 10;157(3):580-94. Epub 2014 Apr 10.

Howard Hughes Medical Institute, Chevy Chase, MD 20815, USA; Department of Pathology and Center for Cancer Research, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA; Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA. Electronic address:

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http://dx.doi.org/10.1016/j.cell.2014.02.030DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4004670PMC
April 2014

Next-generation molecular genetics of brain tumours.

Curr Opin Neurol 2013 Dec;26(6):681-7

aDepartment of Pathology and Center for Cancer Research, Massachusetts General Hospital and Harvard Medical School, Boston bBroad Institute of Harvard and MIT, Cambridge, Massachusetts, USA.

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http://dx.doi.org/10.1097/WCO.0000000000000027DOI Listing
December 2013

Epigenetic reprogramming in cancer.

Science 2013 Mar;339(6127):1567-70

Howard Hughes Medical Institute, Chevy Chase, MD 20815, USA.

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http://dx.doi.org/10.1126/science.1230184DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3821556PMC
March 2013

A tell-tail sign of chromatin: histone mutations drive pediatric glioblastoma.

Cancer Cell 2012 Mar;21(3):329-31

Howard Hughes Medical Institute, Chevy Chase, MD 20815, USA.

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http://dx.doi.org/10.1016/j.ccr.2012.03.001DOI Listing
March 2012