Publications by authors named "Mario Castro"

100Publications

Type 2 inflammation in the sputum of adolescents with asthma.

Ann Allergy Asthma Immunol 2020 Dec 2. Epub 2020 Dec 2.

Division of Pulmonary, Critical Care and Sleep Medicine, University of Kansas Medical Center, Kansas City, Kansas.

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December 2020

The emerging role of quantitative imaging in asthma.

Br J Radiol 2020 Dec 3:20201133. Epub 2020 Dec 3.

Division of Pulmonary, Critical Care, and Sleep Medicine, Department of Medicine, University of Kansas School of Medicine, Kansas City, KS, USA.

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December 2020

Testing structural identifiability by a simple scaling method.

PLoS Comput Biol 2020 11 3;16(11):e1008248. Epub 2020 Nov 3.

Theoretical Biology and Bioinformatics, Utrecht University, Utrecht, The Netherlands.

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November 2020

Lung function trajectories and bronchial hyperresponsiveness during childhood following severe RSV bronchiolitis in infancy.

Pediatr Allergy Immunol 2020 Oct 24. Epub 2020 Oct 24.

The Division of Pulmonary, Critical Care and Sleep Medicine, University of Kansas School of Medicine, Kansas City, KS, USA.

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October 2020

The turning point and end of an expanding epidemic cannot be precisely forecast.

Proc Natl Acad Sci U S A 2020 10 1;117(42):26190-26196. Epub 2020 Oct 1.

Grupo Interdisciplinar de Sistemas Complejos, 28911 Madrid, Spain;

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October 2020

Sex effects in the association between airway microbiome and asthma.

Ann Allergy Asthma Immunol 2020 12 12;125(6):652-657.e3. Epub 2020 Sep 12.

Department of Medicine, Washington University School of Medicine, St. Louis, Missouri. Electronic address:

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December 2020

Neck recurrence in papillary thyroid carcinoma.

Rev Col Bras Cir 2020 12;47:e20202545. Epub 2020 Aug 12.

Irmandade da Santa Casa da Misericórdia de Santos, Santos, SP, Brazil.

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September 2020

Risk Factors Associated With Bronchiolitis in Puerto Rican Children.

Pediatr Emerg Care 2020 Jun 11. Epub 2020 Jun 11.

Department of Emergency Medicine, School of Medicine, Medical Sciences Campus, University of Puerto Rico, San Juan, Puerto Rico.

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June 2020

Predicting the Response to Bronchial Thermoplasty: The Needier, the Better.

J Allergy Clin Immunol Pract 2020 Apr;8(4):1261-1262

University of Kansas School of Medicine, Kansas City, Kan. Electronic address:

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April 2020

Short-course systemic corticosteroids in asthma: striking the balance between efficacy and safety.

Eur Respir Rev 2020 Mar 3;29(155). Epub 2020 Apr 3.

Novartis Pharmaceuticals Corporation, East Hanover, NJ, USA.

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March 2020

Going Beyond "Bio-markers," Think "Life-markers".

Chest 2020 03;157(3):503-505

Asthma and Airway Disease Research Center, University of Arizona, Tucson, AZ.

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March 2020

Precision Medicine in Asthma-Using Phenotypes to Understand Endotypes That Lead Us to New Therapeutic Options.

J Allergy Clin Immunol Pract 2020 02;8(2):496-497

Pulmonary, Critical Care and Sleep Medicine, Department of Medicine, University of Kansas School of Medicine, Kansas City, Kan.

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February 2020

A Bayesian multi-risks survival (MRS) model in the presence of double censorings.

Biometrics 2020 Dec 6;76(4):1297-1309. Epub 2020 Feb 6.

Department of Medical Oncology and Radiation Oncology, Dana-Farber Cancer Institute and Brigham and Women's Hospital, Boston, Massachusetts.

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December 2020

On the use of the modified power series family of distributions in a cure rate model context.

Stat Methods Med Res 2020 07 27;29(7):1831-1845. Epub 2019 Sep 27.

Instituto de Ciências Matemáticas e de Computação, Universidade de São Paulo, Brazil.

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July 2020

Step-Up Therapy in Black Children and Adults with Poorly Controlled Asthma.

N Engl J Med 2019 09;381(13):1227-1239

From National Jewish Health (M.E.W., R.C., J.T.O.), Denver, and University of Colorado School of Medicine (M.E.W., S.J.S., R.C., F.H., J.T.O.) and Children's Hospital Colorado (S.J.S.), Aurora - all in Colorado; Wake Forest School of Medicine (V.E.O., W.C.M., S.P.P.), Winston-Salem, North Carolina Clinical Research (C.F.L.), Raleigh, and Duke University Medical Center (N.L., L.Q.), Durham - all in North Carolina; Ann and Robert H. Lurie Children's Hospital of Chicago (J.A.P., R.G.R.), University of Illinois at Chicago (J.A.K., H.K.), Rush University Medical Center (J.M.), University of Chicago (E.N., J.S., S. White), and Northwestern University Feinberg School of Medicine (L.J.S.) - all in Chicago; Penn State University (V.C., S.J.K., D.M.), Hershey, and Allegheny General Hospital (D.G.) and University of Pittsburgh Medical Center (S. Wenzel), Pittsburgh - all in Pennsylvania; Nemours Children's Health System, Jacksonville (J.J.L., K.V.B., J.L.), and University of South Florida Morsani College of Medicine, Tampa (J.-C.C.) - both in Florida; University of Arizona Health Sciences, Tucson (E.R.B., M.K., F.M., D.A.M.); Washington University School of Medicine, St. Louis (L.B.B., A.B., M.C.); University of California, San Francisco (UCSF), San Francisco (M.B., M.D.C., S.C.L., D.L.) and UCSF Benioff Children's Hospital, Oakland (M.B., D.L.) - both in California; Brigham and Women's Hospital and Harvard Medical School (J.-C.C., N.G., E.I.) and Boston Children's Hospital (W.P., W.S.) - all in Boston; University Hospitals Rainbow Babies and Children's Hospital, Case Western Reserve University School of Medicine, Cleveland (J.F.C., K.R.); University of Wisconsin-Madison, Madison (L.D., D.J.J., R.F.L., C.A.S.) and Aurora Sinai Medical Center, Milwaukee (L.S.-V.) - both in Wisconsin; Columbia University Irving Medical Center, New York, (E.D.); Emory University, Atlanta (A.M.F.); and University of New Mexico, Albuquerque (H.R.).

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September 2019

Is Your Patient with Uncontrolled Severe Asthma Not Responding to a Biologic?

J Allergy Clin Immunol Pract 2019 Sep - Oct;7(7):2284-2285

Division of Pulmonary and Critical Care, Washington University in St Louis, St. Louis, Mo. Electronic address:

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May 2020

Safety of Reslizumab in Uncontrolled Asthma with Eosinophilia: A Pooled Analysis from 6 Trials.

J Allergy Clin Immunol Pract 2020 02 9;8(2):540-548.e1. Epub 2019 Aug 9.

Department of Medicine, Pediatrics, and Radiology, Washington University School of Medicine, St Louis, Mo.

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February 2020

A Pragmatic Trial of Symptom-Based Inhaled Corticosteroid Use in African-American Children with Mild Asthma.

J Allergy Clin Immunol Pract 2020 01 30;8(1):176-185.e2. Epub 2019 Jul 30.

Department of Medicine, Division of Pulmonary and Critical Care Medicine, Washington University School of Medicine, Saint Louis, Mo.

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January 2020

Outcomes following mepolizumab treatment discontinuation: real-world experience from an open-label trial.

Allergy Asthma Clin Immunol 2019 10;15:37. Epub 2019 Jun 10.

7Division of Pulmonary and Critical Care Medicine, Washington University School of Medicine, St. Louis, MO USA.

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June 2019

IL7 receptor signaling in T cells: A mathematical modeling perspective.

Wiley Interdiscip Rev Syst Biol Med 2019 09 28;11(5):e1447. Epub 2019 May 28.

Department of Applied Mathematics, School of Mathematics, University of Leeds, Leeds, UK.

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September 2019

Mometasone or Tiotropium in Mild Asthma with a Low Sputum Eosinophil Level.

N Engl J Med 2019 05 19;380(21):2009-2019. Epub 2019 May 19.

From the Division of Pulmonary and Critical Care Medicine and the Cardiovascular Research Institute (S.C.L., H.A.B., J.V.F., P.G.W.) and the Department of Pediatrics, Epidemiology, and Biostatistics (M.D.C.), University of California, San Francisco, San Francisco; the University of Illinois at Chicago (J.A.K.), the Department of Pediatrics, Rush University Medical Center (J.N.M.), Ann and Robert Lurie Children's Hospital of Chicago (J.A.P.), and Northwestern University, Feinberg School of Medicine (L.S.) - all in Chicago; the Department of Public Health Sciences, Penn State University, Hershey (T.S.K., V.M.C., D.T.M., A.-M.D.), and the University of Pittsburgh Asthma Institute (S.W., F.H.) and Allegheny General Hospital (D.G.), Pittsburgh - all in Pennsylvania; Nemours Children's Hospital, University of Central Florida College of Medicine, Orlando (J.E.L., K.V.B.), and Nemours Children's Health System, Jacksonville (J.E.L., K.V.B.) - both in Florida; the Department of Pediatrics and Medicine, National Jewish Health, Denver (R.C., S.J.S., M.E.W.), and Children's Hospital Colorado, Aurora (R.C., S.J.S., M.E.W.) - both in Colorado; Duke Allergy, Asthma, and Airway Center, Duke University School of Medicine, Durham (N.L., M.K., L.Q.), Wake Forest University School of Medicine, Winston-Salem (A.H., W.M., S.P.P.), and North Carolina Clinical Research, Raleigh (C.L.) - all in North Carolina; the Departments of Pediatrics and Medicine, Washington University in St. Louis School of Medicine, St. Louis (L.B.B., M.C.); Brigham and Women's Hospital and Harvard Medical School (J.C.C., E.I.) and Boston Children's Hospital (W.P.) - all in Boston; Rainbow Babies and Children's Hospital, Cleveland (J.C., R.M., K.R.); the University of Wisconsin, Madison (L.D., D.J., R.F.L., C.A.S.); Columbia University, New York (E.D.); the Department of Pediatrics, Emory University, Atlanta (A.M.F.); and the Arizona Respiratory Center, University of Arizona, Tucson (F.D.M., W.J.M.).

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May 2019

Reply to Yilmaz: Selection of Biologics for Type 2-High Asthma.

Am J Respir Crit Care Med 2019 09;200(6):791-792

Washington University School of MedicineSt. Louis, Missouriand.

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September 2019

Biologics for Severe Asthma: Treatment-Specific Effects Are Important in Choosing a Specific Agent.

J Allergy Clin Immunol Pract 2019 May - Jun;7(5):1379-1392

Division of Pulmonary and Critical Care Medicine, Department of Medicine, Washington University in Saint Louis School of Medicine, Saint Louis, Mo. Electronic address:

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August 2020

Fate of a Naive T Cell: A Stochastic Journey.

Front Immunol 2019 6;10:194. Epub 2019 Mar 6.

Department of Applied Mathematics, School of Mathematics, University of Leeds, Leeds, United Kingdom.

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January 2020

Harmonized outcome measures for use in asthma patient registries and clinical practice.

J Allergy Clin Immunol 2019 09 9;144(3):671-681.e1. Epub 2019 Mar 9.

Division of Pulmonary, Allergy, and Critical Care Medicine, NorthShore University HealthSystem, Chicago, Ill.

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September 2019

Otitis media and mastoiditis in temporal bones of prehistoric Chilean populations. A paleopathological and paleoepidemiological study.

Acta Otolaryngol 2019 Apr 22;139(4):340-344. Epub 2019 Feb 22.

f Department of Anthropology , Museo Nacional de Historia Natural , Santiago , Chile.

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April 2019

Bronchial Thermoplasty.

Clin Chest Med 2019 03;40(1):193-207

Department of Internal Medicine, Division of Pulmonary, Critical Care, and Sleep Medicine, Yale University School of Medicine, 300 Cedar Street, New Haven, CT 06520, USA. Electronic address:

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March 2019

Role of Biologics in Asthma.

Am J Respir Crit Care Med 2019 02;199(4):433-445

1 Division of Pulmonary and Critical Care, Department of Medicine, Washington University School of Medicine, St. Louis, Missouri; and.

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February 2019

Mastoid osteoma in a prehispanic cranium (1390 A.D.) from Northern Chile.

Int J Paleopathol 2019 03 26;24:141-143. Epub 2018 Oct 26.

Biomedical Modeling Laboratory, Clínica Las Condes, Lo Fontecilla 441, Santiago 7591046, Chile.

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March 2019

Predicting response to bronchial thermoplasty in patients with severe uncontrolled asthma: An elusive goal.

Respirology 2019 01 15;24(1):11-12. Epub 2018 Oct 15.

Department of Internal Medicine, Division of Pulmonary and Critical Care Medicine, Washington University School of Medicine, St Louis, MO, USA.

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January 2019

First passage events in biological systems with non-exponential inter-event times.

Sci Rep 2018 10 10;8(1):15054. Epub 2018 Oct 10.

Department of Applied Mathematics, School of Mathematics, University of Leeds, Leeds, LS2 9JT, UK.

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October 2018

Reslizumab Compared with Benralizumab in Patients with Eosinophilic Asthma: A Systematic Literature Review and Network Meta-Analysis.

J Allergy Clin Immunol Pract 2019 01 11;7(1):122-130.e1. Epub 2018 Sep 11.

Division of Pulmonary and Critical Care Medicine, Departments of Medicine and Pediatrics, Washington University, St Louis, Mo.

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January 2019

Bronchial Thermoplasty: A Decade of Experience: State of the Art.

J Allergy Clin Immunol Pract 2019 01 5;7(1):71-80. Epub 2018 Sep 5.

Division of Pulmonology and Critical Care Medicine, Washington University School of Medicine, St Louis, Mo.

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January 2019

Noise Is Not Error: Detecting Parametric Heterogeneity Between Epidemiologic Time Series.

Front Microbiol 2018 12;9:1529. Epub 2018 Jul 12.

Grupo Interdisciplinar de Sistemas Complejos and DNL, Universidad Pontificia Comillas, Madrid, Spain.

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July 2018

Evaluation of lung function in patients submitted to total laryngectomy.

Braz J Otorhinolaryngol 2019 Sep - Oct;85(5):623-627. Epub 2018 Jun 29.

Universidade de São Paulo (USP), Faculdade de Medicina, Departamento de Cirurgia de Cabeça e Pescoço, São Paulo, SP, Brazil.

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April 2020

Assessing covariate effects using Jeffreys-type prior in the Cox model in the presence of a monotone partial likelihood.

J Stat Theory Pract 2018 12;12(1):23-41. Epub 2017 Apr 12.

Department of Statistics, University of Connecticut, Storrs, Connecticut, USA.

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April 2017

Efficacy and Safety of Dupilumab in Glucocorticoid-Dependent Severe Asthma.

N Engl J Med 2018 06 21;378(26):2475-2485. Epub 2018 May 21.

From LungenClinic Grosshansdorf, Grosshansdorf, and Christian Albrechts University Kiel, Kiel - both in Germany (K.F.R.); McMaster University and St. Joseph's Healthcare, Hamilton, ON, Canada (P.N.); Ghent University Hospital, Ghent, Belgium (G.B.); Fundación CIDEA (Centro de Investigación de Enfermedades Alérgicas y Respiratorias), Buenos Aires (J.F.M.); Washington University School of Medicine, St. Louis (M.C.); Peninsula Research Associates, Rolling Hills Estates, CA (L.S.); Sanofi, Bridgewater, NJ (H.Z., B.N.S., H.S., G.P., C.A., A.T.); Regeneron Pharmaceuticals, Tarrytown, NY (J.D.H., J.C., N.A., M.R., B.A., N.M.H.G., N.S., G.D.Y.); and Sanofi, Chilly Mazarin, France (A.K.).

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June 2018

Dupilumab Efficacy and Safety in Moderate-to-Severe Uncontrolled Asthma.

N Engl J Med 2018 06 21;378(26):2486-2496. Epub 2018 May 21.

From the Washington University School of Medicine, St. Louis (M.C.); David Geffen School of Medicine at the University of California, Los Angeles, Los Angeles (J. Corren), and Peninsula Research Associates, Rolling Hills Estates (L.S.) - both in California; Oxford Respiratory National Institute for Health Research Biomedical Research Centre, University of Oxford, Oxford, United Kingdom (I.D.P.); Fundación CIDEA (Centro de Investigación de Enfermedades Alérgicas y Respiratorias), Buenos Aires (J.M.); the University of Pittsburgh Asthma Institute, University of Pittsburgh, Pittsburgh (S.W.); LungenClinic Grosshansdorf, Grosshansdorf, and Christian Albrechts University Kiel, Kiel - both in Germany (K.F.R.); the Division of Allergy, Pulmonary, and Critical Care Medicine, University of Wisconsin School of Medicine and Public Health, Madison (W.W.B.); the Asthma and Allergy Center, Bellevue, NE (L.F.); the University of British Columbia, Vancouver, Canada (J.M.F.); Campbelltown Hospital and Western Sydney University, Sydney (C.K.); the Faculty of Medicine, Kindai University, Osakasayama, Japan (Y.T.); Sanofi, Bridgewater, NJ (B.Z., H.S., G.P., B.N.S., A.T.); Regeneron Pharmaceuticals, Tarrytown, NY (N.A., M.R., B.A., J. Chao, N.M.H.G., J.D.H., N.S., G.D.Y.); Sanofi, Chilly-Mazarin, France (A.K.); and Sanofi, Prague, Czech Republic (R.M.).

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June 2018

Refractory airway type 2 inflammation in a large subgroup of asthmatic patients treated with inhaled corticosteroids.

J Allergy Clin Immunol 2019 01 7;143(1):104-113.e14. Epub 2018 Mar 7.

Division of Pulmonary and Critical Care Medicine, Department of Medicine and the Cardiovascular Research Institute, University of California San Francisco, San Francisco, Calif. Electronic address:

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January 2019

Recurrent wheezing in children following human metapneumovirus infection.

J Allergy Clin Immunol 2018 07 2;142(1):297-301.e2. Epub 2018 Mar 2.

Washington University School of Medicine in St Louis, St Louis, Mo. Electronic address:

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July 2018

Lumen area change (Delta Lumen) between inspiratory and expiratory multidetector computed tomography as a measure of severe outcomes in asthmatic patients.

J Allergy Clin Immunol 2018 12 10;142(6):1773-1780.e9. Epub 2018 Feb 10.

Department of Radiology, University of Wisconsin, Madison, Wis; Department of Medical Physics, University of Wisconsin, Madison, Wis; Department of Biomedical Engineering, University of Wisconsin, Madison, Wis. Electronic address:

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December 2018