Publications by authors named "Mario A Acuña"

14Publications

Mice lacking spinal α2GABA receptors: Altered GABAergic neurotransmission, diminished GABAergic antihyperalgesia, and potential compensatory mechanisms preventing a hyperalgesic phenotype.

Brain Res 2020 Aug 18;1741:146889. Epub 2020 May 18.

Institute of Pharmacology and Toxicology, University of Zurich, CH-8057 Zurich, Switzerland; Institute of Pharmaceutical Sciences, Swiss Federal Institute of Technology (ETH) Zurich, CH-8093 Zurich, Switzerland. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.brainres.2020.146889DOI Listing
August 2020

TP003 is a non-selective benzodiazepine site agonist that induces anxiolysis via α2GABA receptors.

Neuropharmacology 2018 12 18;143:71-78. Epub 2018 Sep 18.

Institute of Pharmacology and Toxicology, University of Zurich, Winterthurerstrasse 190, CH-8057, Zurich, Switzerland; Institute of Pharmaceutical Sciences, Swiss Federal Institute of Technology (ETH) Zurich, Vladimir Prelog Weg 4, CH-8093, Zurich, Switzerland; Drug Discovery Network Zurich (DDNZ), Winterthurerstrasse 190, CH-8057, Zurich, Switzerland. Electronic address:

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S00283908183067
Publisher Site
http://dx.doi.org/10.1016/j.neuropharm.2018.09.026DOI Listing
December 2018

Glycine receptors and glycine transporters: targets for novel analgesics?

Cell Mol Life Sci 2018 02 8;75(3):447-465. Epub 2017 Aug 8.

Department of Physiology, University of Concepción, Concepción, Chile.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s00018-017-2622-xDOI Listing
February 2018

The clobazam metabolite N-desmethyl clobazam is an α2 preferring benzodiazepine with an improved therapeutic window for antihyperalgesia.

Neuropharmacology 2016 10 5;109:366-375. Epub 2016 Jul 5.

Division of Clinical Pharmacology and Toxicology, Multidisciplinary Pain Center, Department of Anesthesiology, Pharmacology and Intensive Care, Geneva University Hospitals, University of Geneva, 4 rue Gabrielle-Perret-Gentil, CH-1211 Geneva, Switzerland.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.neuropharm.2016.07.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4981430PMC
October 2016

Analgesia and unwanted benzodiazepine effects in point-mutated mice expressing only one benzodiazepine-sensitive GABAA receptor subtype.

Nat Commun 2015 Apr 13;6:6803. Epub 2015 Apr 13.

1] Institute of Pharmacology and Toxicology, University of Zurich, Winterthurerstrasse 190, CH-8057 Zurich, Switzerland [2] Center for Neuroscience Zurich (ZNZ), Winterthurerstrasse 190, CH-8057 Zurich, Switzerland [3] Institute of Pharmaceutical Sciences, Swiss Federal Institute of Technology (ETH) Zurich, Vladimir-Prelog-Weg 4, CH-8093 Zurich, Switzerland.

View Article

Download full-text PDF

Source
http://www.nature.com/articles/ncomms7803
Publisher Site
http://dx.doi.org/10.1038/ncomms7803DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4829939PMC
April 2015

Restoring the spinal pain gate: GABA(A) receptors as targets for novel analgesics.

Adv Pharmacol 2015 14;73:71-96. Epub 2015 Jan 14.

Institute of Pharmacology and Toxicology, University of Zurich, Zurich, Switzerland.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/bs.apha.2014.11.007DOI Listing
August 2015

Endoplasmic reticulum-associated degradation controls cell surface expression of γ-aminobutyric acid, type B receptors.

J Biol Chem 2013 Nov 10;288(48):34897-905. Epub 2013 Oct 10.

From the Institute of Pharmacology and Toxicology, University of Zurich, 8057 Zurich, Switzerland.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1074/jbc.M113.514745DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3843101PMC
November 2013

Altered voltage dependent calcium currents in a neuronal cell line derived from the cerebral cortex of a trisomy 16 fetal mouse, an animal model of Down syndrome.

Neurotox Res 2012 Jul 28;22(1):59-68. Epub 2011 Dec 28.

Program of Molecular and Clinical Pharmacology, ICBM, Faculty of Medicine, University of Chile, Clasificador 7, Independencia 1027, 8389100, Independencia, Santiago, Chile.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s12640-011-9304-5DOI Listing
July 2012