Publications by authors named "Marina Pajic"

75Publications

Fats and Mets, KRAS-Driven Lipid Dysregulation Affects Metastatic Potential in Pancreatic Cancer.

Authors:
Jennifer Man Marina Pajic Anthony M Joshua

Cancer Res 2020 Nov;80(22):4886-4887

The Garvan Institute of Medical Research, Darlinghurst, Sydney, New South Wales, Australia.

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November 2020

Targeting DNA Damage Response and Replication Stress in Pancreatic Cancer.

Authors:
Stephan B Dreyer Rosie Upstill-Goddard Viola Paulus-Hock Clara Paris Eirini-Maria Lampraki Eloise Dray Bryan Serrels Giuseppina Caligiuri Selma Rebus Dennis Plenker Zachary Galluzzo Holly Brunton Richard Cunningham Mathias Tesson Craig Nourse Ulla-Maja Bailey Marc Jones Kim Moran-Jones Derek W Wright Fraser Duthie Karin Oien Lisa Evers Colin J McKay Grant A McGregor Aditi Gulati Rachel Brough Ilirjana Bajrami Stephan Pettitt Michele L Dziubinski Juliana Candido Frances Balkwill Simon T Barry Robert Grützmann Lola Rahib Amber Johns Marina Pajic Fieke E M Froeling Phillip Beer Elizabeth A Musgrove Gloria M Petersen Alan Ashworth Margaret C Frame Howard C Crawford Diane M Simeone Chris Lord Debabrata Mukhopadhyay Christian Pilarsky David A Tuveson Susanna L Cooke Nigel B Jamieson Jennifer P Morton Owen J Sansom Peter J Bailey Andrew V Biankin David K Chang

Gastroenterology 2021 Jan 9;160(1):362-377.e13. Epub 2020 Oct 9.

Wolfson Wohl Cancer Research Centre, Institute of Cancer Sciences, University of Glasgow, Glasgow, Scotland, United Kingdom; West of Scotland Pancreatic Unit, Glasgow Royal Infirmary, Glasgow, United Kingdom; South Western Sydney Clinical School, Faculty of Medicine, University of New South Wales, Liverpool, Australia. Electronic address:

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January 2021

Precision Oncology in Surgery: Patient Selection for Operable Pancreatic Cancer.

Authors:
Stephan B Dreyer Mark Pinese Nigel B Jamieson Christopher J Scarlett Emily K Colvin Marina Pajic Amber L Johns Jeremy L Humphris Jianmin Wu Mark J Cowley Angela Chou Adnan M Nagrial Lorraine Chantrill Venessa T Chin Marc D Jones Kim Moran-Jones Christopher Ross Carter Euan J Dickson Jaswinder S Samra Neil D Merrett Anthony J Gill James G Kench Fraser Duthie David K Miller Susanna Cooke Daniela Aust Thomas Knösel Petra Rümmele Robert Grützmann Christian Pilarsky Nam Q Nguyen Elizabeth A Musgrove Peter J Bailey Colin J McKay Andrew V Biankin David K Chang

Ann Surg 2020 08;272(2):366-376

Wolfson Wohl Cancer Research Centre, Institute of Cancer Sciences, University of Glasgow, Scotland, United Kingdom.

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August 2020

MTOR signaling orchestrates stress-induced mutagenesis, facilitating adaptive evolution in cancer.

Authors:
Arcadi Cipponi David L Goode Justin Bedo Mark J McCabe Marina Pajic David R Croucher Alvaro Gonzalez Rajal Simon R Junankar Darren N Saunders Pavel Lobachevsky Anthony T Papenfuss Danielle Nessem Max Nobis Sean C Warren Paul Timpson Mark Cowley Ana C Vargas Min R Qiu Daniele G Generali Shivakumar Keerthikumar Uyen Nguyen Niall M Corcoran Georgina V Long Jean-Yves Blay David M Thomas

Science 2020 06;368(6495):1127-1131

The Kinghorn Cancer Centre, Garvan Institute of Medical Research, Darlinghurst, NSW, Australia.

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June 2020

HNF4A and GATA6 Loss Reveals Therapeutically Actionable Subtypes in Pancreatic Cancer.

Authors:
Holly Brunton Giuseppina Caligiuri Richard Cunningham Rosie Upstill-Goddard Ulla-Maja Bailey Ian M Garner Craig Nourse Stephan Dreyer Marc Jones Kim Moran-Jones Derek W Wright Viola Paulus-Hock Colin Nixon Gemma Thomson Nigel B Jamieson Grant A McGregor Lisa Evers Colin J McKay Aditi Gulati Rachel Brough Ilirjana Bajrami Stephen J Pettitt Michele L Dziubinski Simon T Barry Robert Grützmann Robert Brown Edward Curry Marina Pajic Elizabeth A Musgrove Gloria M Petersen Emma Shanks Alan Ashworth Howard C Crawford Diane M Simeone Fieke E M Froeling Christopher J Lord Debabrata Mukhopadhyay Christian Pilarsky Sean E Grimmond Jennifer P Morton Owen J Sansom David K Chang Peter J Bailey Andrew V Biankin

Cell Rep 2020 05;31(6):107625

Institute of Cancer Sciences, University of Glasgow, Garscube Estate, Switchback Road, Bearsden, Glasgow G61 1QH, Scotland; West of Scotland Pancreatic Unit, Glasgow Royal Infirmary, Glasgow G31 2ER, UK; South Western Sydney Clinical School, Faculty of Medicine, University of New South Wales, Sydney, NSW, Australia. Electronic address:

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May 2020

PGRMC1 phosphorylation affects cell shape, motility, glycolysis, mitochondrial form and function, and tumor growth.

Authors:
Bashar M Thejer Partho P Adhikary Amandeep Kaur Sarah L Teakel Ashleigh Van Oosterum Ishith Seth Marina Pajic Katherine M Hannan Megan Pavy Perlita Poh Jalal A Jazayeri Thiri Zaw Dana Pascovici Marina Ludescher Michael Pawlak Juan C Cassano Lynne Turnbull Mitra Jazayeri Alexander C James Craig P Coorey Tara L Roberts Simon J Kinder Ross D Hannan Ellis Patrick Mark P Molloy Elizabeth J New Tanja N Fehm Hans Neubauer Ewa M Goldys Leslie A Weston Michael A Cahill

BMC Mol Cell Biol 2020 Apr 3;21(1):24. Epub 2020 Apr 3.

School of Biomedical Sciences, Charles Sturt University, Wagga Wagga, NSW, 2650, Australia.

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April 2020

Effective targeting of intact and proteolysed CDCP1 for imaging and treatment of pancreatic ductal adenocarcinoma.

Authors:
Thomas Kryza Tashbib Khan Simon Puttick Chao Li Kamil A Sokolowski Brian Wc Tse Tahleesa Cuda Nicholas Lyons Madeline Gough Julia Yin Ashleigh Parkin Elena I Deryugina James P Quigley Ruby H P Law James C Whisstock Andrew D Riddell Andrew P Barbour David K Wyld Paul A Thomas Stephen Rose Cameron E Snell Marina Pajic Yaowu He John D Hooper

Theranostics 2020 4;10(9):4116-4133. Epub 2020 Mar 4.

Mater Research Institute - The University of Queensland, Translational Research Institute, Woolloongabba, QLD, Australia.

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March 2020

Rho-ROCK Signaling in Normal Physiology and as a Key Player in Shaping the Tumor Microenvironment.

Authors:
Sean Porazinski Ashleigh Parkin Marina Pajic

Adv Exp Med Biol 2020 ;1223:99-127

Personalised Cancer Therapeutics Lab, The Kinghorn Cancer Centre, Sydney, NSW, Australia.

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February 2020

Systematic functional identification of cancer multi-drug resistance genes.

Authors:
Man-Tat Lau Shila Ghazanfar Ashleigh Parkin Angela Chou Jourdin R Rouaen Jamie B Littleboy Danielle Nessem Thang M Khuong Damien Nevoltris Peter Schofield David Langley Daniel Christ Jean Yang Marina Pajic G Gregory Neely

Genome Biol 2020 02 7;21(1):27. Epub 2020 Feb 7.

The Dr. John and Anne Chong Lab for Functional Genomics, Charles Perkins Centre and School of Life & Environmental Sciences, The University of Sydney, Sydney, NSW, 2006, Australia.

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February 2020

MCL-1 antagonism enhances the anti-invasive effects of dasatinib in pancreatic adenocarcinoma.

Authors:
Lesley Castillo Adelaide I J Young Amanda Mawson Pia Schafranek Angela M Steinmann Danielle Nessem Ashleigh Parkin Amber Johns Angela Chou Andrew M K Law Morghan C Lucas Kendelle J Murphy Niantao Deng David Gallego-Ortega Catherine E Caldon Paul Timpson Marina Pajic Christopher J Ormandy Samantha R Oakes

Oncogene 2020 02 18;39(8):1821-1829. Epub 2019 Nov 18.

Cancer Research Division, Garvan Institute of Medical Research and the Kinghorn Cancer Centre, 384 Victoria Street, Darlinghurst, NSW, 2010, Australia.

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February 2020

RET gene rearrangements occur in a subset of pancreatic acinar cell carcinomas.

Authors:
Angela Chou Ian S Brown M Priyanthi Kumarasinghe Aurel Perren Denise Riley Yoomee Kim Marina Pajic Angela Steinmann Vivek Rathi Nigel B Jamieson Joanne Verheij Stijn van Roessel Chris B Nahm Anubhav Mittal Jaswinder Samra Anthony J Gill

Mod Pathol 2020 04 26;33(4):657-664. Epub 2019 Sep 26.

Cancer Diagnosis and Pathology Group, Kolling Institute of Medical Research, Royal North Shore Hospital, St Leonards, NSW, Australia.

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April 2020

CAF hierarchy driven by pancreatic cancer cell p53-status creates a pro-metastatic and chemoresistant environment via perlecan.

Authors:
Claire Vennin Pauline Mélénec Romain Rouet Max Nobis Aurélie S Cazet Kendelle J Murphy David Herrmann Daniel A Reed Morghan C Lucas Sean C Warren Zehra Elgundi Mark Pinese Gabriella Kalna Daniel Roden Monisha Samuel Anaiis Zaratzian Shane T Grey Andrew Da Silva Wilfred Leung Suresh Mathivanan Yingxiao Wang Anthony W Braithwaite Daniel Christ Ales Benda Ashleigh Parkin Phoebe A Phillips John M Whitelock Anthony J Gill Owen J Sansom David R Croucher Benjamin L Parker Marina Pajic Jennifer P Morton Thomas R Cox Paul Timpson

Nat Commun 2019 08 12;10(1):3637. Epub 2019 Aug 12.

The Garvan Institute of Medical Research & The Kinghorn Cancer Centre, Sydney, NSW, 2010, Australia.

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August 2019

Targeting the complexity of Src signalling in the tumour microenvironment of pancreatic cancer: from mechanism to therapy.

Authors:
Ashleigh Parkin Jennifer Man Paul Timpson Marina Pajic

FEBS J 2019 09 5;286(18):3510-3539. Epub 2019 Aug 5.

The Kinghorn Cancer Centre, The Garvan Institute of Medical Research, Sydney, Australia.

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September 2019

PAK inhibition by PF-3758309 enhanced the sensitivity of multiple chemotherapeutic reagents in patient-derived pancreatic cancer cell lines.

Authors:
Kai Wang Nhi Huynh Xiao Wang Marina Pajic Ashleigh Parkin Jennifer Man Graham S Baldwin Mehrdad Nikfarjam Hong He

Am J Transl Res 2019 15;11(6):3353-3364. Epub 2019 Jun 15.

Department of Surgery, University of Melbourne, Austin Health Studley Road, Heidelberg, Victoria 3084, Australia.

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June 2019

The Evolving Understanding of the Molecular and Therapeutic Landscape of Pancreatic Ductal Adenocarcinoma.

Authors:
Ashleigh Parkin Jennifer Man Angela Chou Adnan M Nagrial Jaswinder Samra Anthony J Gill Paul Timpson Marina Pajic

Diseases 2018 Nov 13;6(4). Epub 2018 Nov 13.

The Kinghorn Cancer Centre, The Garvan Institute of Medical Research, 384 Victoria St, Darlinghurst, Sydney, NSW 2010, Australia.

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November 2018

ATRX loss is an independent predictor of poor survival in pancreatic neuroendocrine tumors.

Authors:
Angela Chou Malinda Itchins Philip R de Reuver Jennifer Arena Adele Clarkson Amy Sheen Loretta Sioson Veronica Cheung Aurel Perren Christopher Nahm Anubhav Mittal Jaswinder S Samra Marina Pajic Anthony J Gill

Hum Pathol 2018 12 3;82:249-257. Epub 2018 Aug 3.

Cancer Diagnosis and Pathology Group, Kolling Institute of Medical Research, Royal North Shore Hospital, St Leonards, NSW 2065, Australia; University of Sydney, Sydney, NSW 2006, Australia; NSW Health Pathology, Department of Anatomical Pathology, Royal North Shore Hospital, St Leonards, NSW 2065, Australia. Electronic address:

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December 2018

Changes in cell morphology guide identification of tubulin as the off-target for protein kinase inhibitors.

Authors:
Monira Hoque Ramzi H Abbassi Danielle Froio Jennifer Man Terrance G Johns Brett W Stringer Bryan W Day Marina Pajic Michael Kassiou Lenka Munoz

Pharmacol Res 2018 08 23;134:166-178. Epub 2018 Jun 23.

The University of Sydney, Faculty of Medicine and Health, Charles Perkins Centre, NSW 2006, Australia. Electronic address:

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August 2018

Intravital Imaging to Monitor Therapeutic Response in Moving Hypoxic Regions Resistant to PI3K Pathway Targeting in Pancreatic Cancer.

Authors:
James R W Conway Sean C Warren David Herrmann Kendelle J Murphy Aurélie S Cazet Claire Vennin Robert F Shearer Monica J Killen Astrid Magenau Pauline Mélénec Mark Pinese Max Nobis Anaiis Zaratzian Alice Boulghourjian Andrew M Da Silva Gonzalo Del Monte-Nieto Arne S A Adam Richard P Harvey Jody J Haigh Yingxiao Wang David R Croucher Owen J Sansom Marina Pajic C Elizabeth Caldon Jennifer P Morton Paul Timpson

Cell Rep 2018 06;23(11):3312-3326

Garvan Institute of Medical Research and The Kinghorn Cancer Centre, Cancer Division, Sydney, NSW 2010, Australia; St Vincent's Clinical School, Faculty of Medicine, University of NSW, Sydney, NSW 2010, Australia. Electronic address:

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June 2018

Rho Kinase Inhibition by AT13148 Blocks Pancreatic Ductal Adenocarcinoma Invasion and Tumor Growth.

Authors:
Nicola Rath June Munro Marie Francene Cutiongco Alicja Jagiełło Nikolaj Gadegaard Lynn McGarry Mathieu Unbekandt Evdokia Michalopoulou Jurre J Kamphorst David Sumpton Gillian Mackay Claire Vennin Marina Pajic Paul Timpson Michael F Olson

Cancer Res 2018 06 18;78(12):3321-3336. Epub 2018 Apr 18.

Cancer Research UK Beatson Institute, Glasgow, United Kingdom.

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June 2018

BRAF gene rearrangements can be identified by FISH studies in pancreatic acinar cell carcinoma.

Authors:
Angela Chou Yoomee Kim Jaswinder S Samra Marina Pajic Anthony J Gill

Pathology 2018 04 3;50(3):345-348. Epub 2018 Mar 3.

Cancer Diagnosis and Pathology Group, Kolling Institute of Medical Research, Royal North Shore Hospital, St Leonards, NSW, Australia; University of Sydney, Sydney, NSW, Australia; NSW Health Pathology, Department of Anatomical Pathology, Royal North Shore Hospital, St Leonards, NSW, Australia. Electronic address:

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April 2018

∆133p53 isoform promotes tumour invasion and metastasis via interleukin-6 activation of JAK-STAT and RhoA-ROCK signalling.

Authors:
Hamish Campbell Nicholas Fleming Imogen Roth Sunali Mehta Anna Wiles Gail Williams Claire Vennin Nikola Arsic Ashleigh Parkin Marina Pajic Fran Munro Les McNoe Michael Black John McCall Tania L Slatter Paul Timpson Roger Reddel Pierre Roux Cristin Print Margaret A Baird Antony W Braithwaite

Nat Commun 2018 01 17;9(1):254. Epub 2018 Jan 17.

Children's Medical Research Institute, University of Sydney, Sydney, NSW, 2145, Australia.

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January 2018

Reshaping the Tumor Stroma for Treatment of Pancreatic Cancer.

Authors:
Claire Vennin Kendelle J Murphy Jennifer P Morton Thomas R Cox Marina Pajic Paul Timpson

Gastroenterology 2018 03 26;154(4):820-838. Epub 2017 Dec 26.

The Garvan Institute of Medical Research, Sydney, New South Wales, Australia; The Kinghorn Cancer Center, Sydney, New South Wales, Australia; St Vincent's Clinical School, Faculty of Medicine, University of New South Wales, Sydney, New South Wales, Australia. Electronic address:

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March 2018

Three-dimensional organotypic matrices from alternative collagen sources as pre-clinical models for cell biology.

Authors:
James R W Conway Claire Vennin Aurélie S Cazet David Herrmann Kendelle J Murphy Sean C Warren Lena Wullkopf Alice Boulghourjian Anaiis Zaratzian Andrew M Da Silva Marina Pajic Jennifer P Morton Thomas R Cox Paul Timpson

Sci Rep 2017 12 4;7(1):16887. Epub 2017 Dec 4.

Garvan Institute of Medical Research & The Kinghorn Cancer Centre, Cancer Division, Sydney, NSW 2010, Australia.

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December 2017

miR-139-5p Modulates Radiotherapy Resistance in Breast Cancer by Repressing Multiple Gene Networks of DNA Repair and ROS Defense.

Authors:
Marina Pajic Danielle Froio Sheridan Daly Louise Doculara Ewan Millar Peter H Graham Alison Drury Angela Steinmann Charles E de Bock Alice Boulghourjian Anaiis Zaratzian Susan Carroll Joanne Toohey Sandra A O'Toole Adrian L Harris Francesca M Buffa Harriet E Gee Georgina E Hollway Timothy J Molloy

Cancer Res 2018 01 27;78(2):501-515. Epub 2017 Nov 27.

St Vincent's Clinical School, Faculty of Medicine, University of New South Wales, Sydney, New South Wales, Australia.

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January 2018

Transient targeting of the pancreatic cancer stroma as a 'fine-tuned' anti-tumor and anti-metastatic therapy.

Authors:
Claire Vennin Thomas R Cox Marina Pajic Paul Timpson

Oncotarget 2017 Oct 3;8(49):84635-84636. Epub 2017 Oct 3.

Paul Timpson and Marina Pajic: The Garvan Institute of Medical Research, Darlinghurst, Sydney, NSW & The Kinghorn Cancer Centre, Cancer Division, Australia and St Vincent's Clinical School, Faculty of Medicine, University of NSW, Australia.

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October 2017

Tailored first-line and second-line CDK4-targeting treatment combinations in mouse models of pancreatic cancer.

Authors:
Angela Chou Danielle Froio Adnan M Nagrial Ashleigh Parkin Kendelle J Murphy Venessa T Chin Dalia Wohl Angela Steinmann Rhys Stark Alison Drury Stacey N Walters Claire Vennin Andrew Burgess Mark Pinese Lorraine A Chantrill Mark J Cowley Timothy J Molloy Nicola Waddell Amber Johns Sean M Grimmond David K Chang Andrew V Biankin Owen J Sansom Jennifer P Morton Shane T Grey Thomas R Cox John Turchini Jaswinder Samra Stephen J Clarke Paul Timpson Anthony J Gill Marina Pajic

Gut 2018 12 28;67(12):2142-2155. Epub 2017 Oct 28.

The Kinghorn Cancer Centre, Garvan Institute of Medical Research, Sydney, New South Wales, Australia.

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December 2018

Effective modulation of stromal signaling through ROCK inhibition: Is it all in the timing?

Authors:
Venessa T Chin Claire Vennin Paul Timpson Marina Pajic

Mol Cell Oncol 2017 26;4(5):e1333973. Epub 2017 May 26.

The Kinghorn Cancer Centre, The Garvan Institute of Medical Research, Darlinghurst, Sydney, Australia.

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May 2017

A RhoA-FRET Biosensor Mouse for Intravital Imaging in Normal Tissue Homeostasis and Disease Contexts.

Authors:
Max Nobis David Herrmann Sean C Warren Shereen Kadir Wilfred Leung Monica Killen Astrid Magenau David Stevenson Morghan C Lucas Nadine Reischmann Claire Vennin James R W Conway Alice Boulghourjian Anaiis Zaratzian Andrew M Law David Gallego-Ortega Christopher J Ormandy Stacey N Walters Shane T Grey Jacqueline Bailey Tatyana Chtanova Julian M W Quinn Paul A Baldock Peter I Croucher Juliane P Schwarz Agata Mrowinska Lei Zhang Herbert Herzog Andrius Masedunskas Edna C Hardeman Peter W Gunning Gonzalo Del Monte-Nieto Richard P Harvey Michael S Samuel Marina Pajic Ewan J McGhee Anna-Karin E Johnsson Owen J Sansom Heidi C E Welch Jennifer P Morton Douglas Strathdee Kurt I Anderson Paul Timpson

Cell Rep 2017 Oct;21(1):274-288

The Garvan Institute of Medical Research, St. Vincent's Clinical School, Faculty of Medicine, University of New South Wales, Sydney, NSW 2010, Australia. Electronic address:

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October 2017

Targeting ROCK activity to disrupt and prime pancreatic cancer for chemotherapy.

Authors:
Claire Vennin Nicola Rath Marina Pajic Michael F Olson Paul Timpson

Small GTPases 2020 01 3;11(1):45-52. Epub 2017 Oct 3.

The Garvan Institute of Medical Research, Sydney, Australia.

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January 2020

Corrigendum: Whole-genome landscape of pancreatic neuroendocrine tumours.

Authors:
Aldo Scarpa David K Chang Katia Nones Vincenzo Corbo Ann-Marie Patch Peter Bailey Rita T Lawlor Amber L Johns David K Miller Andrea Mafficini Borislav Rusev Maria Scardoni Davide Antonello Stefano Barbi Katarzyna O Sikora Sara Cingarlini Caterina Vicentini Skye McKay Michael C J Quinn Timothy J C Bruxner Angelika N Christ Ivon Harliwong Senel Idrisoglu Suzanne McLean Craig Nourse Ehsan Nourbakhsh Peter J Wilson Matthew J Anderson J Lynn Fink Felicity Newell Nick Waddell Oliver Holmes Stephen H Kazakoff Conrad Leonard Scott Wood Qinying Xu Shivashankar Hiriyur Nagaraj Eliana Amato Irene Dalai Samantha Bersani Ivana Cataldo Angelo P Dei Tos Paola Capelli Maria Vittoria Davì Luca Landoni Anna Malpaga Marco Miotto Vicki L J Whitehall Barbara A Leggett Janelle L Harris Jonathan Harris Marc D Jones Jeremy Humphris Lorraine A Chantrill Venessa Chin Adnan M Nagrial Marina Pajic Christopher J Scarlett Andreia Pinho Ilse Rooman Christopher Toon Jianmin Wu Mark Pinese Mark Cowley Andrew Barbour Amanda Mawson Emily S Humphrey Emily K Colvin Angela Chou Jessica A Lovell Nigel B Jamieson Fraser Duthie Marie-Claude Gingras William E Fisher Rebecca A Dagg Loretta M S Lau Michael Lee Hilda A Pickett Roger R Reddel Jaswinder S Samra James G Kench Neil D Merrett Krishna Epari Nam Q Nguyen Nikolajs Zeps Massimo Falconi Michele Simbolo Giovanni Butturini George Van Buren Stefano Partelli Matteo Fassan Kum Kum Khanna Anthony J Gill David A Wheeler Richard A Gibbs Elizabeth A Musgrove Claudio Bassi Giampaolo Tortora Paolo Pederzoli John V Pearson Nicola Waddell Andrew V Biankin Sean M Grimmond

Nature 2017 10 27;550(7677):548. Epub 2017 Sep 27.

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October 2017

Selected Alkylating Agents Can Overcome Drug Tolerance of G-like Tumor Cells and Eradicate BRCA1-Deficient Mammary Tumors in Mice.

Authors:
Marina Pajic Sohvi Blatter Charlotte Guyader Maaike Gonggrijp Ariena Kersbergen Aslι Küçükosmanoğlu Wendy Sol Rinske Drost Jos Jonkers Piet Borst Sven Rottenberg

Clin Cancer Res 2017 Nov 18;23(22):7020-7033. Epub 2017 Aug 18.

Institute of Animal Pathology, Vetsuisse Faculty, University of Bern, Bern, Switzerland.

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November 2017

Lost in translation: returning germline genetic results in genome-scale cancer research.

Authors:
Amber L Johns Skye H McKay Jeremy L Humphris Mark Pinese Lorraine A Chantrill R Scott Mead Katherine Tucker Lesley Andrews Annabel Goodwin Conrad Leonard Hilda A High Katia Nones Ann-Marie Patch Neil D Merrett Nick Pavlakis Karin S Kassahn Jaswinder S Samra David K Miller David K Chang Marina Pajic John V Pearson Sean M Grimmond Nicola Waddell Nikolajs Zeps Anthony J Gill Andrew V Biankin

Genome Med 2017 04 28;9(1):41. Epub 2017 Apr 28.

Cancer Research Program, Garvan Institute of Medical Research, Kinghorn Cancer Centre, Sydney, Australia.

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April 2017

Transient tissue priming via ROCK inhibition uncouples pancreatic cancer progression, sensitivity to chemotherapy, and metastasis.

Authors:
Claire Vennin Venessa T Chin Sean C Warren Morghan C Lucas David Herrmann Astrid Magenau Pauline Melenec Stacey N Walters Gonzalo Del Monte-Nieto James R W Conway Max Nobis Amr H Allam Rachael A McCloy Nicola Currey Mark Pinese Alice Boulghourjian Anaiis Zaratzian Arne A S Adam Celine Heu Adnan M Nagrial Angela Chou Angela Steinmann Alison Drury Danielle Froio Marc Giry-Laterriere Nathanial L E Harris Tri Phan Rohit Jain Wolfgang Weninger Ewan J McGhee Renee Whan Amber L Johns Jaswinder S Samra Lorraine Chantrill Anthony J Gill Maija Kohonen-Corish Richard P Harvey Andrew V Biankin T R Jeffry Evans Kurt I Anderson Shane T Grey Christopher J Ormandy David Gallego-Ortega Yingxiao Wang Michael S Samuel Owen J Sansom Andrew Burgess Thomas R Cox Jennifer P Morton Marina Pajic Paul Timpson

Sci Transl Med 2017 04;9(384)

The Kinghorn Cancer Centre, Garvan Institute of Medical Research, Sydney, New South Wales 2010, Australia.

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April 2017

Whole-genome landscape of pancreatic neuroendocrine tumours.

Authors:
Aldo Scarpa David K Chang Katia Nones Vincenzo Corbo Ann-Marie Patch Peter Bailey Rita T Lawlor Amber L Johns David K Miller Andrea Mafficini Borislav Rusev Maria Scardoni Davide Antonello Stefano Barbi Katarzyna O Sikora Sara Cingarlini Caterina Vicentini Skye McKay Michael C J Quinn Timothy J C Bruxner Angelika N Christ Ivon Harliwong Senel Idrisoglu Suzanne McLean Craig Nourse Ehsan Nourbakhsh Peter J Wilson Matthew J Anderson J Lynn Fink Felicity Newell Nick Waddell Oliver Holmes Stephen H Kazakoff Conrad Leonard Scott Wood Qinying Xu Shivashankar Hiriyur Nagaraj Eliana Amato Irene Dalai Samantha Bersani Ivana Cataldo Angelo P Dei Tos Paola Capelli Maria Vittoria Davì Luca Landoni Anna Malpaga Marco Miotto Vicki L J Whitehall Barbara A Leggett Janelle L Harris Jonathan Harris Marc D Jones Jeremy Humphris Lorraine A Chantrill Venessa Chin Adnan M Nagrial Marina Pajic Christopher J Scarlett Andreia Pinho Ilse Rooman Christopher Toon Jianmin Wu Mark Pinese Mark Cowley Andrew Barbour Amanda Mawson Emily S Humphrey Emily K Colvin Angela Chou Jessica A Lovell Nigel B Jamieson Fraser Duthie Marie-Claude Gingras William E Fisher Rebecca A Dagg Loretta M S Lau Michael Lee Hilda A Pickett Roger R Reddel Jaswinder S Samra James G Kench Neil D Merrett Krishna Epari Nam Q Nguyen Nikolajs Zeps Massimo Falconi Michele Simbolo Giovanni Butturini George Van Buren Stefano Partelli Matteo Fassan Kum Kum Khanna Anthony J Gill David A Wheeler Richard A Gibbs Elizabeth A Musgrove Claudio Bassi Giampaolo Tortora Paolo Pederzoli John V Pearson Nicola Waddell Andrew V Biankin Sean M Grimmond

Nature 2017 03 15;543(7643):65-71. Epub 2017 Feb 15.

University of Melbourne Centre for Cancer Research, University of Melbourne, Melbourne, 3010, Victoria, Australia.

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March 2017

Mitochondrial mutations and metabolic adaptation in pancreatic cancer.

Authors:
Rae-Anne Hardie Ellen van Dam Mark Cowley Ting-Li Han Seher Balaban Marina Pajic Mark Pinese Mary Iconomou Robert F Shearer Jessie McKenna David Miller Nicola Waddell John V Pearson Sean M Grimmond Leonid Sazanov Andrew V Biankin Silas Villas-Boas Andrew J Hoy Nigel Turner Darren N Saunders

Cancer Metab 2017 30;5. Epub 2017 Jan 30.

The Kinghorn Cancer Centre, Garvan Institute of Medical Research, Darlinghurst, NSW 2010 Australia.

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January 2017

Hypermutation In Pancreatic Cancer.

Authors:
Jeremy L Humphris Ann-Marie Patch Katia Nones Peter J Bailey Amber L Johns Skye McKay David K Chang David K Miller Marina Pajic Karin S Kassahn Michael C J Quinn Timothy J C Bruxner Angelika N Christ Ivon Harliwong Senel Idrisoglu Suzanne Manning Craig Nourse Ehsan Nourbakhsh Andrew Stone Peter J Wilson Matthew Anderson J Lynn Fink Oliver Holmes Stephen Kazakoff Conrad Leonard Felicity Newell Nick Waddell Scott Wood Ronald S Mead Qinying Xu Jianmin Wu Mark Pinese Mark J Cowley Marc D Jones Adnan M Nagrial Venessa T Chin Lorraine A Chantrill Amanda Mawson Angela Chou Christopher J Scarlett Andreia V Pinho Ilse Rooman Marc Giry-Laterriere Jaswinder S Samra James G Kench Neil D Merrett Christopher W Toon Krishna Epari Nam Q Nguyen Andrew Barbour Nikolajs Zeps Nigel B Jamieson Colin J McKay C Ross Carter Euan J Dickson Janet S Graham Fraser Duthie Karin Oien Jane Hair Jennifer P Morton Owen J Sansom Robert Grützmann Ralph H Hruban Anirban Maitra Christine A Iacobuzio-Donahue Richard D Schulick Christopher L Wolfgang Richard A Morgan Rita T Lawlor Borislav Rusev Vincenzo Corbo Roberto Salvia Ivana Cataldo Giampaolo Tortora Margaret A Tempero Oliver Hofmann James R Eshleman Christian Pilarsky Aldo Scarpa Elizabeth A Musgrove Anthony J Gill John V Pearson Sean M Grimmond Nicola Waddell Andrew V Biankin

Gastroenterology 2017 01 15;152(1):68-74.e2. Epub 2016 Nov 15.

Wolfson Wohl Cancer Research Centre, Institute of Cancer Sciences, University of Glasgow, Glasgow, Scotland, United Kingdom; Department of Surgery, Bankstown Hospital, Bankstown, Sydney, New South Wales, Australia; South Western Sydney Clinical School, Faculty of Medicine, University of New South Wales Australia, Liverpool, New South Wales, Australia; West of Scotland Pancreatic Unit, Glasgow Royal Infirmary, Glasgow, United Kingdom. Electronic address:

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January 2017

The PARP Inhibitor AZD2461 Provides Insights into the Role of PARP3 Inhibition for Both Synthetic Lethality and Tolerability with Chemotherapy in Preclinical Models.

Authors:
Lenka Oplustil O'Connor Stuart L Rulten Aaron N Cranston Rajesh Odedra Henry Brown Janneke E Jaspers Louise Jones Charlotte Knights Bastiaan Evers Attilla Ting Robert H Bradbury Marina Pajic Sven Rottenberg Jos Jonkers David Rudge Niall M B Martin Keith W Caldecott Alan Lau Mark J O'Connor

Cancer Res 2016 10 22;76(20):6084-6094. Epub 2016 Aug 22.

AstraZeneca, Alderley Park, Macclesfield, United Kingdom.

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October 2016

GATA6 regulates EMT and tumour dissemination, and is a marker of response to adjuvant chemotherapy in pancreatic cancer.

Authors:
Paola Martinelli Enrique Carrillo-de Santa Pau Trevor Cox Bruno Sainz Nelson Dusetti William Greenhalf Lorenzo Rinaldi Eithne Costello Paula Ghaneh Núria Malats Markus Büchler Marina Pajic Andrew V Biankin Juan Iovanna John Neoptolemos Francisco X Real

Gut 2017 09 20;66(9):1665-1676. Epub 2016 Jun 20.

Epithelial Carcinogenesis Group, Spanish National Cancer Research Center-CNIO, Madrid, Spain.

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September 2017

Resolution of Novel Pancreatic Ductal Adenocarcinoma Subtypes by Global Phosphotyrosine Profiling.

Authors:
Emily S Humphrey Shih-Ping Su Adnan M Nagrial Falko Hochgräfe Marina Pajic Gillian M Lehrbach Robert G Parton Alpha S Yap Lisa G Horvath David K Chang Andrew V Biankin Jianmin Wu Roger J Daly

Mol Cell Proteomics 2016 08 3;15(8):2671-85. Epub 2016 Jun 3.

¶Cancer Program, Biomedicine Discovery Institute and Department of Biochemistry and Molecular Biology, Level 1, Building 77, Monash University, VIC 3800, Australia;

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August 2016

Glutathione biosynthesis is upregulated at the initiation of MYCN-driven neuroblastoma tumorigenesis.

Authors:
Daniel R Carter Selina K Sutton Marina Pajic Jayne Murray Eric O Sekyere Jamie Fletcher Anneleen Beckers Katleen De Preter Frank Speleman Rani E George Michelle Haber Murray D Norris Belamy B Cheung Glenn M Marshall

Mol Oncol 2016 06 2;10(6):866-78. Epub 2016 Mar 2.

Children's Cancer Institute, Lowy Cancer Research Centre, University of New South Wales, Randwick 2031, Australia; Kids Cancer Centre, Sydney Children's Hospital, Randwick 2031, Australia. Electronic address:

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June 2016

Genomic analyses identify molecular subtypes of pancreatic cancer.

Authors:
Peter Bailey David K Chang Katia Nones Amber L Johns Ann-Marie Patch Marie-Claude Gingras David K Miller Angelika N Christ Tim J C Bruxner Michael C Quinn Craig Nourse L Charles Murtaugh Ivon Harliwong Senel Idrisoglu Suzanne Manning Ehsan Nourbakhsh Shivangi Wani Lynn Fink Oliver Holmes Venessa Chin Matthew J Anderson Stephen Kazakoff Conrad Leonard Felicity Newell Nick Waddell Scott Wood Qinying Xu Peter J Wilson Nicole Cloonan Karin S Kassahn Darrin Taylor Kelly Quek Alan Robertson Lorena Pantano Laura Mincarelli Luis N Sanchez Lisa Evers Jianmin Wu Mark Pinese Mark J Cowley Marc D Jones Emily K Colvin Adnan M Nagrial Emily S Humphrey Lorraine A Chantrill Amanda Mawson Jeremy Humphris Angela Chou Marina Pajic Christopher J Scarlett Andreia V Pinho Marc Giry-Laterriere Ilse Rooman Jaswinder S Samra James G Kench Jessica A Lovell Neil D Merrett Christopher W Toon Krishna Epari Nam Q Nguyen Andrew Barbour Nikolajs Zeps Kim Moran-Jones Nigel B Jamieson Janet S Graham Fraser Duthie Karin Oien Jane Hair Robert Grützmann Anirban Maitra Christine A Iacobuzio-Donahue Christopher L Wolfgang Richard A Morgan Rita T Lawlor Vincenzo Corbo Claudio Bassi Borislav Rusev Paola Capelli Roberto Salvia Giampaolo Tortora Debabrata Mukhopadhyay Gloria M Petersen Donna M Munzy William E Fisher Saadia A Karim James R Eshleman Ralph H Hruban Christian Pilarsky Jennifer P Morton Owen J Sansom Aldo Scarpa Elizabeth A Musgrove Ulla-Maja Hagbo Bailey Oliver Hofmann Robert L Sutherland David A Wheeler Anthony J Gill Richard A Gibbs John V Pearson Nicola Waddell Andrew V Biankin Sean M Grimmond

Nature 2016 Mar 24;531(7592):47-52. Epub 2016 Feb 24.

Queensland Centre for Medical Genomics, Institute for Molecular Bioscience, The University of Queensland, St Lucia, Brisbane, Queensland 4072, Australia.

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March 2016

Rho-associated kinase signalling and the cancer microenvironment: novel biological implications and therapeutic opportunities.

Authors:
Venessa T Chin Adnan M Nagrial Angela Chou Andrew V Biankin Anthony J Gill Paul Timpson Marina Pajic

Expert Rev Mol Med 2015 Oct 28;17:e17. Epub 2015 Oct 28.

The Kinghorn Cancer Centre,Cancer Division,Garvan Institute of Medical Research,384 Victoria St,Darlinghurst,Sydney,NSW 2010,Australia.

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October 2015

Second-line treatment in inoperable pancreatic adenocarcinoma: A systematic review and synthesis of all clinical trials.

Authors:
Adnan M Nagrial Venessa T Chin Katrin M Sjoquist Marina Pajic Lisa G Horvath Andrew V Biankin Desmond Yip

Crit Rev Oncol Hematol 2015 Dec 26;96(3):483-97. Epub 2015 Jul 26.

Department of Medical Oncology, The Canberra Hospital, Garran, ACT, Australia; ANU Medical School, Australian National University, Acton, ACT, Australia.

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December 2015

The dynamics of Rho GTPase signaling and implications for targeting cancer and the tumor microenvironment.

Authors:
Marina Pajic David Herrmann Claire Vennin James Rw Conway Venessa T Chin Anna-Karin E Johnsson Heidi Ce Welch Paul Timpson

Small GTPases 2015 23;6(2):123-33. Epub 2015 Jun 23.

a The Kinghorn Cancer Center; Cancer Division; Garvan Institute of Medical Research ; Sydney , Australia.

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April 2016

Imaging fibrosis in pancreatic cancer using second harmonic generation.

Authors:
Claire Vennin Marina Pajic Paul Timpson

Pancreatology 2015 Mar-Apr;15(2):200-1

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December 2015

Precision Medicine for Advanced Pancreas Cancer: The Individualized Molecular Pancreatic Cancer Therapy (IMPaCT) Trial.

Authors:
Lorraine A Chantrill Adnan M Nagrial Clare Watson Amber L Johns Mona Martyn-Smith Skye Simpson Scott Mead Marc D Jones Jaswinder S Samra Anthony J Gill Nicole Watson Venessa T Chin Jeremy L Humphris Angela Chou Belinda Brown Adrienne Morey Marina Pajic Sean M Grimmond David K Chang David Thomas Lucille Sebastian Katrin Sjoquist Sonia Yip Nick Pavlakis Ray Asghari Sandra Harvey Peter Grimison John Simes Andrew V Biankin

Clin Cancer Res 2015 May;21(9):2029-37

The Kinghorn Cancer Centre, Cancer Division, Garvan Institute of Medical Research, Sydney, New South Wales, Australia. Wolfson Wohl Cancer Research Centre, Institute of Cancer Sciences, University of Glasgow, Glasgow, Scotland. Department of Surgery, Bankstown Hospital, Sydney, New South Wales, Australia. South Western Sydney Clinical School, Faculty of Medicine, University of NSW, Liverpool, New South Wales, Australia. West of Scotland Pancreatic Unit, Glasgow Royal Infirmary, Glasgow, United Kingdom.

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May 2015

Whole genomes redefine the mutational landscape of pancreatic cancer.

Authors:
Nicola Waddell Marina Pajic Ann-Marie Patch David K Chang Karin S Kassahn Peter Bailey Amber L Johns David Miller Katia Nones Kelly Quek Michael C J Quinn Alan J Robertson Muhammad Z H Fadlullah Tim J C Bruxner Angelika N Christ Ivon Harliwong Senel Idrisoglu Suzanne Manning Craig Nourse Ehsan Nourbakhsh Shivangi Wani Peter J Wilson Emma Markham Nicole Cloonan Matthew J Anderson J Lynn Fink Oliver Holmes Stephen H Kazakoff Conrad Leonard Felicity Newell Barsha Poudel Sarah Song Darrin Taylor Nick Waddell Scott Wood Qinying Xu Jianmin Wu Mark Pinese Mark J Cowley Hong C Lee Marc D Jones Adnan M Nagrial Jeremy Humphris Lorraine A Chantrill Venessa Chin Angela M Steinmann Amanda Mawson Emily S Humphrey Emily K Colvin Angela Chou Christopher J Scarlett Andreia V Pinho Marc Giry-Laterriere Ilse Rooman Jaswinder S Samra James G Kench Jessica A Pettitt Neil D Merrett Christopher Toon Krishna Epari Nam Q Nguyen Andrew Barbour Nikolajs Zeps Nigel B Jamieson Janet S Graham Simone P Niclou Rolf Bjerkvig Robert Grützmann Daniela Aust Ralph H Hruban Anirban Maitra Christine A Iacobuzio-Donahue Christopher L Wolfgang Richard A Morgan Rita T Lawlor Vincenzo Corbo Claudio Bassi Massimo Falconi Giuseppe Zamboni Giampaolo Tortora Margaret A Tempero Anthony J Gill James R Eshleman Christian Pilarsky Aldo Scarpa Elizabeth A Musgrove John V Pearson Andrew V Biankin Sean M Grimmond

Nature 2015 Feb;518(7540):495-501

1] Queensland Centre for Medical Genomics, Institute for Molecular Bioscience, The University of Queensland, St Lucia, Brisbane, Queensland 4072, Australia [2] Wolfson Wohl Cancer Research Centre, Institute of Cancer Sciences, University of Glasgow, Garscube Estate, Switchback Road, Bearsden, Glasgow G61 1BD, UK.

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February 2015

The epigenetic agents suberoylanilide hydroxamic acid and 5‑AZA‑2' deoxycytidine decrease cell proliferation, induce cell death and delay the growth of MiaPaCa2 pancreatic cancer cells in vivo.

Authors:
Johana M Susanto Emily K Colvin Mark Pinese David K Chang Marina Pajic Amanda Mawson C Elizabeth Caldon Elizabeth A Musgrove Susan M Henshall Robert L Sutherland Andrew V Biankin Christopher J Scarlett

Int J Oncol 2015 May 16;46(5):2223-30. Epub 2015 Feb 16.

Cancer Research Program, Garvan Institute of Medical Research, Sydney, NSW 2010, Australia.

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May 2015

SOX9 regulates ERBB signalling in pancreatic cancer development.

Authors:
Adrien Grimont Andreia V Pinho Mark J Cowley Cécile Augereau Amanda Mawson Marc Giry-Laterrière Géraldine Van den Steen Nicola Waddell Marina Pajic Christine Sempoux Jianmin Wu Sean M Grimmond Andrew V Biankin Frédéric P Lemaigre Ilse Rooman Patrick Jacquemin

Gut 2015 Nov 21;64(11):1790-9. Epub 2014 Oct 21.

Université catholique de Louvain, de Duve Institute, Brussels, Belgium.

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November 2015

Clinical and pathologic features of familial pancreatic cancer.

Authors:
Jeremy L Humphris Amber L Johns Skye H Simpson Mark J Cowley Marina Pajic David K Chang Adnan M Nagrial Venessa T Chin Lorraine A Chantrill Mark Pinese R Scott Mead Anthony J Gill Jaswinder S Samra James G Kench Elizabeth A Musgrove Katherine M Tucker Allan D Spigelman Nic Waddell Sean M Grimmond Andrew V Biankin

Cancer 2014 Dec 14;120(23):3669-75. Epub 2014 Oct 14.

The Kinghorn Cancer Center, Cancer Research Program, Garvan Institute of Medical Research, Darlinghurst, New South Wales, Australia.

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December 2014

Personalising pancreas cancer treatment: When tissue is the issue.

Authors:
Katrin M Sjoquist Venessa T Chin Lorraine A Chantrill Chelsie O'Connor Chris Hemmings David K Chang Angela Chou Marina Pajic Amber L Johns Adnan M Nagrial Andrew V Biankin Desmond Yip

World J Gastroenterol 2014 Jun;20(24):7849-63

Katrin M Sjoquist, NHMRC Clinical Trials Centre, University of Sydney, Sydney NSW 1450, Australia.

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June 2014

Returning individual research results for genome sequences of pancreatic cancer.

Authors:
Amber L Johns David K Miller Skye H Simpson Anthony J Gill Karin S Kassahn Jeremy L Humphris Jaswinder S Samra Katherine Tucker Lesley Andrews David K Chang Nicola Waddell Marina Pajic John V Pearson Sean M Grimmond Andrew V Biankin Nikolajs Zeps

Genome Med 2014 29;6(5):42. Epub 2014 May 29.

St John of God Subiaco, Perth, WA, 6008, Australia ; School of Surgery, The University of Western Australia, Perth, WA, 6009, Australia.

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June 2014

Gemcitabine and CHK1 inhibition potentiate EGFR-directed radioimmunotherapy against pancreatic ductal adenocarcinoma.

Authors:
Fares Al-Ejeh Marina Pajic Wei Shi Murugan Kalimutho Mariska Miranda Adnan M Nagrial Angela Chou Andrew V Biankin Sean M Grimmond Michael P Brown Kum Kum Khanna

Clin Cancer Res 2014 Jun 16;20(12):3187-97. Epub 2014 May 16.

Authors' Affiliations: Signal Transduction Laboratory, QIMR Berghofer Medical Research Institute, Herston; Queensland Centre for Medical Genomics, Institute for Molecular Bioscience, The University of Queensland, St Lucia, Queensland; The Kinghorn Cancer Centre, Cancer Division, Garvan Institute of Medical Research; St Vincent's Clinical School, Faculty of Medicine, University of NSW; Department of Anatomical Pathology, SYDPATH, St Vincent's Hospital, Darlinghurst, New South Wales; Australian Pancreatic Cancer Genome Initiative, for the full list of contributors see http://www.pancreaticcancer.net.au/apgi/collaborators; Cancer Clinical Trials Unit, Royal Adelaide Hospital Cancer Centre, and Centre for Cancer Biology, SA Pathology; School of Medicine, University of Adelaide, Adelaide, Australia; and Wolfson Wohl Cancer Research Centre, Institute of Cancer Sciences, University of Glasgow, Glasgow, Scotland, United KingdomAuthors' Affiliations: Signal Transduction Laboratory, QIMR Berghofer Medical Research Institute, Herston; Queensland Centre for Medical Genomics, Institute for Molecular Bioscience, The University of Queensland, St Lucia, Queensland; The Kinghorn Cancer Centre, Cancer Division, Garvan Institute of Medical Research; St Vincent's Clinical School, Faculty of Medicine, University of NSW; Department of Anatomical Pathology, SYDPATH, St Vincent's Hospital, Darlinghurst, New South Wales; Australian Pancreatic Cancer Genome Initiative, for the full list of contributors see http://www.pancreaticcancer.net.au/apgi/collaborators; Cancer Clinical Trials Unit, Royal Adelaide Hospital Cancer Centre, and Centre for Cancer Biology, SA Pathology; School of Medicine, University of Adelaide, Adelaide, Australia; and Wolfson Wohl Cancer Research Centre, Institute of Cancer Sciences, University of Glasgow, Glasgow, Scotland, United Kingdom.

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June 2014

An analysis of reported motivational orientation in students undertaking doctoral studies in the biomedical sciences.

Authors:
Matthew W Kemp Timothy J Molloy Marina Pajic Elaine Chapman

BMC Med Educ 2014 Feb 27;14:38. Epub 2014 Feb 27.

School of Women's and Infants' Health, M550, The University of Western Australia, Perth WA6009, Australia.

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February 2014

Genome-wide DNA methylation patterns in pancreatic ductal adenocarcinoma reveal epigenetic deregulation of SLIT-ROBO, ITGA2 and MET signaling.

Authors:
Katia Nones Nic Waddell Sarah Song Ann-Marie Patch David Miller Amber Johns Jianmin Wu Karin S Kassahn David Wood Peter Bailey Lynn Fink Suzanne Manning Angelika N Christ Craig Nourse Stephen Kazakoff Darrin Taylor Conrad Leonard David K Chang Marc D Jones Michelle Thomas Clare Watson Mark Pinese Mark Cowley Ilse Rooman Marina Pajic Giovanni Butturini Anna Malpaga Vincenzo Corbo Stefano Crippa Massimo Falconi Giuseppe Zamboni Paola Castelli Rita T Lawlor Anthony J Gill Aldo Scarpa John V Pearson Andrew V Biankin Sean M Grimmond

Int J Cancer 2014 Sep 9;135(5):1110-8. Epub 2014 May 9.

Queensland Centre for Medical Genomics, Institute for Molecular Bioscience, The University of Queensland, St Lucia, Brisbane, QLD, Australia.

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September 2014

Somatic point mutation calling in low cellularity tumors.

Authors:
Karin S Kassahn Oliver Holmes Katia Nones Ann-Marie Patch David K Miller Angelika N Christ Ivon Harliwong Timothy J Bruxner Qinying Xu Matthew Anderson Scott Wood Conrad Leonard Darrin Taylor Felicity Newell Sarah Song Senel Idrisoglu Craig Nourse Ehsan Nourbakhsh Suzanne Manning Shivangi Wani Anita Steptoe Marina Pajic Mark J Cowley Mark Pinese David K Chang Anthony J Gill Amber L Johns Jianmin Wu Peter J Wilson Lynn Fink Andrew V Biankin Nicola Waddell Sean M Grimmond John V Pearson

PLoS One 2013 8;8(11):e74380. Epub 2013 Nov 8.

Queensland Centre for Medical Genomics, Institute for Molecular Bioscience, The University of Queensland, Brisbane, Queensland, Australia.

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March 2015

Clinical and molecular characterization of HER2 amplified-pancreatic cancer.

Authors:
Angela Chou Nicola Waddell Mark J Cowley Anthony J Gill David K Chang Ann-Marie Patch Katia Nones Jianmin Wu Mark Pinese Amber L Johns David K Miller Karin S Kassahn Adnan M Nagrial Harpreet Wasan David Goldstein Christopher W Toon Venessa Chin Lorraine Chantrill Jeremy Humphris R Scott Mead Ilse Rooman Jaswinder S Samra Marina Pajic Elizabeth A Musgrove John V Pearson Adrienne L Morey Sean M Grimmond Andrew V Biankin

Genome Med 2013 31;5(8):78. Epub 2013 Aug 31.

Kinghorn Cancer Centre and Garvan Institute of Medical Research, Darlinghurst, Sydney, Australia ; Wolfson Wohl Cancer Research Centre, Institute of Cancer Sciences, University of Glasgow, Glasgow, UK ; West of Scotland Pancreatic Unit, Glasgow Royal Infirmary, Glasgow, UK.

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May 2014

Signatures of mutational processes in human cancer.

Authors:
Ludmil B Alexandrov Serena Nik-Zainal David C Wedge Samuel A J R Aparicio Sam Behjati Andrew V Biankin Graham R Bignell Niccolò Bolli Ake Borg Anne-Lise Børresen-Dale Sandrine Boyault Birgit Burkhardt Adam P Butler Carlos Caldas Helen R Davies Christine Desmedt Roland Eils Jórunn Erla Eyfjörd John A Foekens Mel Greaves Fumie Hosoda Barbara Hutter Tomislav Ilicic Sandrine Imbeaud Marcin Imielinski Marcin Imielinsk Natalie Jäger David T W Jones David Jones Stian Knappskog Marcel Kool Sunil R Lakhani Carlos López-Otín Sancha Martin Nikhil C Munshi Hiromi Nakamura Paul A Northcott Marina Pajic Elli Papaemmanuil Angelo Paradiso John V Pearson Xose S Puente Keiran Raine Manasa Ramakrishna Andrea L Richardson Julia Richter Philip Rosenstiel Matthias Schlesner Ton N Schumacher Paul N Span Jon W Teague Yasushi Totoki Andrew N J Tutt Rafael Valdés-Mas Marit M van Buuren Laura van 't Veer Anne Vincent-Salomon Nicola Waddell Lucy R Yates Jessica Zucman-Rossi P Andrew Futreal Ultan McDermott Peter Lichter Matthew Meyerson Sean M Grimmond Reiner Siebert Elías Campo Tatsuhiro Shibata Stefan M Pfister Peter J Campbell Michael R Stratton

Nature 2013 Aug 14;500(7463):415-21. Epub 2013 Aug 14.

Cancer Genome Project, Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridgeshire CB10 1SA, UK.

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August 2013

Understanding pancreatic cancer genomes.

Authors:
Mark J Cowley David K Chang Marina Pajic Amber L Johns Nicola Waddell Sean M Grimmond Andrew V Biankin

J Hepatobiliary Pancreat Sci 2013 Aug;20(6):549-56

The Kinghorn Cancer Centre, 370 Victoria St, Darlinghurst, Australia; Cancer Research Program, Garvan Institute of Medical Research, 384 Victoria St, Darlinghurst, Sydney, NSW, 2010, Australia.

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August 2013

Histomolecular phenotypes and outcome in adenocarcinoma of the ampulla of vater.

Authors:
David K Chang Nigel B Jamieson Amber L Johns Christopher J Scarlett Marina Pajic Angela Chou Mark Pinese Jeremy L Humphris Marc D Jones Christopher Toon Adnan M Nagrial Lorraine A Chantrill Venessa T Chin Andreia V Pinho Ilse Rooman Mark J Cowley Jianmin Wu R Scott Mead Emily K Colvin Jaswinder S Samra Vincenzo Corbo Claudio Bassi Massimo Falconi Rita T Lawlor Stefano Crippa Nicola Sperandio Samantha Bersani Euan J Dickson Mohamed A A Mohamed Karin A Oien Alan K Foulis Elizabeth A Musgrove Robert L Sutherland James G Kench C Ross Carter Anthony J Gill Aldo Scarpa Colin J McKay Andrew V Biankin

J Clin Oncol 2013 Apr 25;31(10):1348-56. Epub 2013 Feb 25.

Cancer Research Program, Garvan Institute of Medical Research, Sydney, NSW 2010 Australia.

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April 2013

Pancreatic cancer genomes reveal aberrations in axon guidance pathway genes.

Authors:
Andrew V Biankin Nicola Waddell Karin S Kassahn Marie-Claude Gingras Lakshmi B Muthuswamy Amber L Johns David K Miller Peter J Wilson Ann-Marie Patch Jianmin Wu David K Chang Mark J Cowley Brooke B Gardiner Sarah Song Ivon Harliwong Senel Idrisoglu Craig Nourse Ehsan Nourbakhsh Suzanne Manning Shivangi Wani Milena Gongora Marina Pajic Christopher J Scarlett Anthony J Gill Andreia V Pinho Ilse Rooman Matthew Anderson Oliver Holmes Conrad Leonard Darrin Taylor Scott Wood Qinying Xu Katia Nones J Lynn Fink Angelika Christ Tim Bruxner Nicole Cloonan Gabriel Kolle Felicity Newell Mark Pinese R Scott Mead Jeremy L Humphris Warren Kaplan Marc D Jones Emily K Colvin Adnan M Nagrial Emily S Humphrey Angela Chou Venessa T Chin Lorraine A Chantrill Amanda Mawson Jaswinder S Samra James G Kench Jessica A Lovell Roger J Daly Neil D Merrett Christopher Toon Krishna Epari Nam Q Nguyen Andrew Barbour Nikolajs Zeps Nipun Kakkar Fengmei Zhao Yuan Qing Wu Min Wang Donna M Muzny William E Fisher F Charles Brunicardi Sally E Hodges Jeffrey G Reid Jennifer Drummond Kyle Chang Yi Han Lora R Lewis Huyen Dinh Christian J Buhay Timothy Beck Lee Timms Michelle Sam Kimberly Begley Andrew Brown Deepa Pai Ami Panchal Nicholas Buchner Richard De Borja Robert E Denroche Christina K Yung Stefano Serra Nicole Onetto Debabrata Mukhopadhyay Ming-Sound Tsao Patricia A Shaw Gloria M Petersen Steven Gallinger Ralph H Hruban Anirban Maitra Christine A Iacobuzio-Donahue Richard D Schulick Christopher L Wolfgang Richard A Morgan Rita T Lawlor Paola Capelli Vincenzo Corbo Maria Scardoni Giampaolo Tortora Margaret A Tempero Karen M Mann Nancy A Jenkins Pedro A Perez-Mancera David J Adams David A Largaespada Lodewyk F A Wessels Alistair G Rust Lincoln D Stein David A Tuveson Neal G Copeland Elizabeth A Musgrove Aldo Scarpa James R Eshleman Thomas J Hudson Robert L Sutherland David A Wheeler John V Pearson John D McPherson Richard A Gibbs Sean M Grimmond

Nature 2012 Nov 24;491(7424):399-405. Epub 2012 Oct 24.

The Kinghorn Cancer Centre, 370 Victoria Street, Darlinghurst, Sydney, New South Wales 2010, Australia.

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November 2012

qpure: A tool to estimate tumor cellularity from genome-wide single-nucleotide polymorphism profiles.

Authors:
Sarah Song Katia Nones David Miller Ivon Harliwong Karin S Kassahn Mark Pinese Marina Pajic Anthony J Gill Amber L Johns Matthew Anderson Oliver Holmes Conrad Leonard Darrin Taylor Scott Wood Qinying Xu Felicity Newell Mark J Cowley Jianmin Wu Peter Wilson Lynn Fink Andrew V Biankin Nic Waddell Sean M Grimmond John V Pearson

PLoS One 2012 25;7(9):e45835. Epub 2012 Sep 25.

Queensland Centre for Medical Genomics, Institute for Molecular Bioscience, University of Queensland, St Lucia, Brisbane, Queensland, Australia.

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May 2013

Impact of intertumoral heterogeneity on predicting chemotherapy response of BRCA1-deficient mammary tumors.

Authors:
Sven Rottenberg Marieke A Vollebergh Bas de Hoon Jorma de Ronde Philip C Schouten Ariena Kersbergen Serge A L Zander Marina Pajic Janneke E Jaspers Martijn Jonkers Martin Lodén Wendy Sol Eline van der Burg Jelle Wesseling Jean-Pierre Gillet Michael M Gottesman Joost Gribnau Lodewyk Wessels Sabine C Linn Jos Jonkers Piet Borst

Cancer Res 2012 May 6;72(9):2350-61. Epub 2012 Mar 6.

Division of Molecular Biology, The Netherlands Cancer Institute, Amsterdam, The Netherlands.

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May 2012

Recruitment and activation of pancreatic stellate cells from the bone marrow in pancreatic cancer: a model of tumor-host interaction.

Authors:
Christopher J Scarlett Emily K Colvin Mark Pinese David K Chang Adrienne L Morey Elizabeth A Musgrove Marina Pajic Minoti Apte Susan M Henshall Robert L Sutherland James G Kench Andrew V Biankin

PLoS One 2011 14;6(10):e26088. Epub 2011 Oct 14.

Cancer Research Program, Garvan Institute of Medical Research, Darlinghurst, Sydney, Australia.

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February 2012

Preclinical strategies to define predictive biomarkers for therapeutically relevant cancer subtypes.

Authors:
Marina Pajic Christopher J Scarlett David K Chang Robert L Sutherland Andrew V Biankin

Hum Genet 2011 Jul 23;130(1):93-101. Epub 2011 Apr 23.

Cancer Research Program, Garvan Institute of Medical Research, Darlinghurst, NSW 2010, Australia.

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July 2011

ABCC1 G2012T single nucleotide polymorphism is associated with patient outcome in primary neuroblastoma and altered stability of the ABCC1 gene transcript.

Authors:
Marina Pajic Jayne Murray Glenn M Marshall Susan P C Cole Murray D Norris Michelle Haber

Pharmacogenet Genomics 2011 May;21(5):270-9

Children's Cancer Institute Australia for Medical Research, Sydney, New South Wales, Australia.

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May 2011

Tumor-initiating cells are not enriched in cisplatin-surviving BRCA1;p53-deficient mammary tumor cells in vivo.

Authors:
Marina Pajic Ariena Kersbergen Frank van Diepen Anita Pfauth Jos Jonkers Piet Borst Sven Rottenberg

Cell Cycle 2010 Sep 13;9(18):3780-91. Epub 2010 Sep 13.

Division of Molecular Biology of the Netherlands Cancer Institute, Amsterdam, The Netherlands.

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September 2010

Sensitivity and acquired resistance of BRCA1;p53-deficient mouse mammary tumors to the topoisomerase I inhibitor topotecan.

Authors:
Serge A L Zander Ariena Kersbergen Eline van der Burg Niels de Water Olaf van Tellingen Sjöfn Gunnarsdottir Janneke E Jaspers Marina Pajic Anders O H Nygren Jos Jonkers Piet Borst Sven Rottenberg

Cancer Res 2010 Feb 9;70(4):1700-10. Epub 2010 Feb 9.

Division of Molecular Biology, The Netherlands Cancer Institute, 1066CX Amsterdam, The Netherlands.

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February 2010

Studying drug resistance using genetically engineered mouse models for breast cancer.

Authors:
Sven Rottenberg Marina Pajic Jos Jonkers

Methods Mol Biol 2010 ;596:33-45

Division of Molecular Biology, The Netherlands Cancer Institute, Amsterdam, The Netherlands.

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January 2010

Moderate increase in Mdr1a/1b expression causes in vivo resistance to doxorubicin in a mouse model for hereditary breast cancer.

Authors:
Marina Pajic Jayasree K Iyer Ariena Kersbergen Eline van der Burg Anders O H Nygren Jos Jonkers Piet Borst Sven Rottenberg

Cancer Res 2009 Aug 4;69(16):6396-404. Epub 2009 Aug 4.

Division of Molecular Biology and Centre for Biomedical Genetics, The Netherlands Cancer Institute, Amsterdam, The Netherlands.

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August 2009

Small-molecule multidrug resistance-associated protein 1 inhibitor reversan increases the therapeutic index of chemotherapy in mouse models of neuroblastoma.

Authors:
Catherine A Burkhart Fujiko Watt Jayne Murray Marina Pajic Anatoly Prokvolit Chengyuan Xue Claudia Flemming Janice Smith Andrei Purmal Nadezhda Isachenko Pavel G Komarov Katerina V Gurova Alan C Sartorelli Glenn M Marshall Murray D Norris Andrei V Gudkov Michelle Haber

Cancer Res 2009 Aug 4;69(16):6573-80. Epub 2009 Aug 4.

Cleveland BioLabs, Inc, Buffalo, New York, USA.

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August 2009

Selective induction of chemotherapy resistance of mammary tumors in a conditional mouse model for hereditary breast cancer.

Authors:
Sven Rottenberg Anders O H Nygren Marina Pajic Fijs W B van Leeuwen Ingrid van der Heijden Koen van de Wetering Xiaoling Liu Karin E de Visser Kenneth G Gilhuijs Olaf van Tellingen Jan P Schouten Jos Jonkers Piet Borst

Proc Natl Acad Sci U S A 2007 Jul 11;104(29):12117-22. Epub 2007 Jul 11.

Division of Molecular Biology and Center of Biomedical Genetics, The Netherlands Cancer Institute, 1066 CX Amsterdam, The Netherlands.

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July 2007

Nucleus pulposus cellular longevity by telomerase gene therapy.

Authors:
Sylvia A Chung Ai Qun Wei David E Connor Graham C Webb Timothy Molloy Marina Pajic Ashish D Diwan

Spine (Phila Pa 1976) 2007 May;32(11):1188-96

Orthopaedic Research Institute, University of New South Wales, St. George Hospital Campus, NSW, Australia.

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May 2007

The role of the multidrug resistance-associated protein 1 gene in neuroblastoma biology and clinical outcome.

Authors:
Marina Pajic Murray D Norris S L Cohn Michelle Haber

Cancer Lett 2005 Oct;228(1-2):241-6

Children's Cancer Institute Australia for Medical Research, P.O. Box 81 Randwick, Sydney, NSW 2031, Australia.

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October 2005

Effect of short-term morphine exposure on P-glycoprotein expression and activity in cancer cell lines.

Authors:
Marina Pajic Mary Bebawy Janelle M Hoskins Basil D Roufogalis Laurent P Rivory

Oncol Rep 2004 May;11(5):1091-5

Children's Cancer Institute of Australia for Medical Research, Randwick, Sydney, NSW 2031, Australia.

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May 2004