Publications by authors named "Marina Konopleva"

100Publications

Mechanisms of Response and Resistance to AML Therapies.

Clin Lymphoma Myeloma Leuk 2020 Sep;20 Suppl 1:S7

MRC Molecular Haematology Unit, Weatherall Institute of Molecular Medicine, Radcliffe Department of Medicine, University of Oxford, Oxford, UK. Electronic address:

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http://dx.doi.org/10.1016/S2152-2650(20)30442-0DOI Listing
September 2020

Harnessing Apoptosis in AML.

Clin Lymphoma Myeloma Leuk 2020 Sep;20 Suppl 1:S61-S64

Department of Leukemia, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Blvd, Houston, Texas, 77030, United States. Electronic address:

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http://dx.doi.org/10.1016/S2152-2650(20)30464-XDOI Listing
September 2020

Approval of tagraxofusp-erzs for blastic plasmacytoid dendritic cell neoplasm.

Blood Adv 2020 Aug;4(16):4020-4027

Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX.

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http://dx.doi.org/10.1182/bloodadvances.2019000173DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7448601PMC
August 2020

Azacitidine and Venetoclax in Previously Untreated Acute Myeloid Leukemia.

N Engl J Med 2020 08;383(7):617-629

From the Department of Leukemia, Division of Cancer Medicine, University of Texas M.D. Anderson Cancer Center, Houston (C.D.D., M.K.); the Department of Internal Medicine, Division of Hematology and Oncology, University of California Davis School of Medicine, Sacramento (B.A.J.), the Department of Hematology and Hematopoietic Cell Transplantation and Gehr Family Center for Leukemia Research, City of Hope Comprehensive Cancer Center, Duarte (V. Pullarkat), and Genentech, South San Francisco (W.-J.H.) - all in California; the Section of Hematology and Oncology, Department of Medicine, University of Chicago Medicine, Chicago (M.J.T.), and AbbVie, North Chicago (Y.Z., J.P.) - both in Illinois; the Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston (J.S.G., A.L.); the Australian Centre for Blood Diseases, Alfred Hospital and Monash University, Melbourne, VIC (A.H.W.); the Department of Internal Medicine III, Ulm University Hospital, Ulm, Germany (H.D.); Hôpital St. Louis, Assistance Publique-Hôpitaux de Paris and Université de Paris, Paris (P.F.); the Third Medical Department for Hematology and Oncology, Hanusch Hospital, Vienna (E.K.); the Department of Hematology, Cliniques Universitaires Saint-Luc, Brussels (V.H.); the Department of Medicine, McMaster University, Hamilton, ON, Canada (B.L.); the Department of Hematology, Hospital Clinic, August Pi i Sunyer Biomedical Research Institute, Barcelona (J.E.); the Institute of Hematology and Hospital of Blood Disease, Chinese Academy of Medical Sciences, Peking Union Medical College, Tianjin, China (J.W.); the Department of Hematology, University Hospital Dubrava, University of Zagreb School of Medicine, Zagreb, Croatia (V. Pejsa); the Department of Clinic Subjects, University Hospital Ostrava-Poruba, Ostrava, Czech Republic (R.H.); Helsinki University Hospital Comprehensive Cancer Center, University of Helsinki, Helsinki (K.P.); the Faculty of Medicine, Department of Hematology, University of Debrecen, Debrecen, Hungary (A.I.); Hadassah Medical Center, Jerusalem (D.L.); the Clinic of Hematology, Department of Internal Medicine, University of Genoa, and San Martino Hospital IRCCS - both in Genoa, Italy (R.M.L.); the Department of Hematology and Cell Therapy, Aichi Cancer Center, Nagoya, Japan (K.Y.); the Department of Internal Medicine, Seoul National University College of Medicine (S.-S.Y.), and the Department of Hematology-Oncology, Samsung Medical Center, Sungkyunkwan University School of Medicine (J.-H.J.) - both in Seoul, South Korea; the Department of Internal Medicine, China Medical University Hospital, Taichung, Taiwan (S.-P.Y.); the Faculty of Medicine, Department of Internal Medicine, Division of Hematology, Ondokuz Mayıs University, Samsun, Turkey (M.T.); and Abramson Cancer Center, University of Pennsylvania, Philadelphia (K.W.P.).

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http://dx.doi.org/10.1056/NEJMoa2012971DOI Listing
August 2020

An expert overview of emerging therapies for acute myeloid leukemia: novel small molecules targeting apoptosis, p53, transcriptional regulation and metabolism.

Expert Opin Investig Drugs 2020 Aug 17:1-16. Epub 2020 Aug 17.

Department of Leukemia, The University of Texas MD Anderson Cancer Center , Houston, TX, USA.

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http://dx.doi.org/10.1080/13543784.2020.1804856DOI Listing
August 2020

Chronic myeloid leukemia presenting in lymphoblastic crisis, a differential diagnosis with Philadelphia-positive B-lymphoblastic leukemia.

Leuk Lymphoma 2020 Jul 23:1-8. Epub 2020 Jul 23.

Department of Hematopathology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.

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http://dx.doi.org/10.1080/10428194.2020.1795160DOI Listing
July 2020

MDM2 inhibition: an important step forward in cancer therapy.

Leukemia 2020 Jul 10. Epub 2020 Jul 10.

Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.

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http://dx.doi.org/10.1038/s41375-020-0949-zDOI Listing
July 2020

Outcome of adults with relapsed/refractory T-cell acute lymphoblastic leukemia or lymphoblastic lymphoma.

Am J Hematol 2020 Jun 5. Epub 2020 Jun 5.

Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.

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http://dx.doi.org/10.1002/ajh.25896DOI Listing
June 2020

Utilizing Synergistic Potential of Mitochondria-Targeting Drugs for Leukemia Therapy.

Front Oncol 2020 3;10:435. Epub 2020 Apr 3.

Department of BioSciences, Rice University, Houston, TX, United States.

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http://dx.doi.org/10.3389/fonc.2020.00435DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7146088PMC
April 2020

Fatty Acid Metabolism, Bone Marrow Adipocytes, and AML.

Front Oncol 2020 18;10:155. Epub 2020 Feb 18.

Section of Molecular Hematology and Therapy, Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX, United States.

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http://dx.doi.org/10.3389/fonc.2020.00155DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7040225PMC
February 2020

Venetoclax in acute myeloid leukemia - current and future directions.

Leuk Lymphoma 2020 Jun 7;61(6):1313-1322. Epub 2020 Feb 7.

Department of Leukemia, M. D. Anderson Cancer Center, Houston, TX, USA.

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http://dx.doi.org/10.1080/10428194.2020.1719098DOI Listing
June 2020

Advances in the Treatment of Acute Myeloid Leukemia: New Drugs and New Challenges.

Cancer Discov 2020 Apr 3;10(4):506-525. Epub 2020 Feb 3.

Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, Texas.

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http://dx.doi.org/10.1158/2159-8290.CD-19-1011DOI Listing
April 2020

Venetoclax for AML: changing the treatment paradigm.

Blood Adv 2019 12;3(24):4326-4335

Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX.

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http://dx.doi.org/10.1182/bloodadvances.2019000937DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6929394PMC
December 2019

Role of tagraxofusp in treating blastic plasmacytoid dendritic cell neoplasm (BPDCN).

Expert Opin Biol Ther 2020 Feb 17;20(2):115-123. Epub 2019 Dec 17.

Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.

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http://dx.doi.org/10.1080/14712598.2020.1701651DOI Listing
February 2020

Recent developments in the treatment of blastic plasmacytoid dendritic cell neoplasm.

Ther Adv Hematol 2019 23;10:2040620719874733. Epub 2019 Sep 23.

Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.

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http://dx.doi.org/10.1177/2040620719874733DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6759709PMC
September 2019

Amino acid metabolism in hematologic malignancies and the era of targeted therapy.

Blood 2019 09 15;134(13):1014-1023. Epub 2019 Aug 15.

Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX.

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http://dx.doi.org/10.1182/blood.2019001034DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6764269PMC
September 2019

Percutaneous coronary intervention and in-hospital outcomes in patients with leukemia: a nationwide analysis.

Catheter Cardiovasc Interv 2020 Jul 13;96(1):53-63. Epub 2019 Aug 13.

Keele Cardiovascular Group, Centre for Prognosis Research, Institute for Primary Care and Health Sciences, Keele University, Keele, UK.

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http://dx.doi.org/10.1002/ccd.28432DOI Listing
July 2020

A mechanism for increased sensitivity of acute myeloid leukemia to mitotoxic drugs.

Cell Death Dis 2019 08 13;10(8):617. Epub 2019 Aug 13.

Department of BioSciences, Rice University, Houston, TX, USA.

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http://dx.doi.org/10.1038/s41419-019-1851-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6692368PMC
August 2019

Targeting PRMT1-mediated FLT3 methylation disrupts maintenance of MLL-rearranged acute lymphoblastic leukemia.

Blood 2019 10;134(15):1257-1268

Department of Hematological Malignancies Translational Science, Gehr Family Center for Leukemia Research, Hematologic Malignancies and Stem Cell Transplantation Institute, Beckman Research Institute, City of Hope Medical Center, Duarte, CA.

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http://dx.doi.org/10.1182/blood.2019002457DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6788006PMC
October 2019

Three-Dimensional Leukemia Co-Culture System for In Vitro High-Content Metabolomics Screening.

SLAS Discov 2019 09 25;24(8):817-828. Epub 2019 Jul 25.

1 Department of Nutritional Sciences, The University of Texas at Austin, Austin, TX, USA.

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http://dx.doi.org/10.1177/2472555219860446DOI Listing
September 2019

Neurotoxic events associated with BCR-ABL1 tyrosine kinase inhibitors: a case series.

Leuk Lymphoma 2019 12 27;60(13):3292-3295. Epub 2019 Jun 27.

Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.

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http://dx.doi.org/10.1080/10428194.2019.1633635DOI Listing
December 2019

Venetoclax-based therapies for acute myeloid leukemia.

Best Pract Res Clin Haematol 2019 06 24;32(2):145-153. Epub 2019 May 24.

Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX, USA. Electronic address:

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http://dx.doi.org/10.1016/j.beha.2019.05.008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6581210PMC
June 2019

Ibrutinib and Venetoclax for First-Line Treatment of CLL.

N Engl J Med 2019 05;380(22):2095-2103

From the Departments of Leukemia (N.J., M. Keating, P.T., A.F., J.B., G.B., K.T., Z.E., T.K., M. Konopleva, Y.A., M.Y., C.D., P.B., M.O., N.P., E.J., K. Sasaki, K. Sondermann, N.C., C.W., A.A., H.K., W.W.), Lymphoma and Myeloma (N.F.), Hematopathology (R.K.-S., K.P., J.J.), Diagnostic Radiology (N.G.), Biostatistics (X.W.), and Experimental Therapeutics (W.P., V.G.), University of Texas M.D. Anderson Cancer Center, Houston.

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http://dx.doi.org/10.1056/NEJMoa1900574DOI Listing
May 2019

Photoacoustic-based oxygen saturation assessment of murine femoral bone marrow in a preclinical model of leukemia.

Photoacoustics 2019 Jun 20;14:31-36. Epub 2019 Feb 20.

Department of Imaging Physics, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.

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http://dx.doi.org/10.1016/j.pacs.2019.01.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6484208PMC
June 2019

Tagraxofusp in Blastic Plasmacytoid Dendritic-Cell Neoplasm.

N Engl J Med 2019 04;380(17):1628-1637

From the University of Texas M.D. Anderson Cancer Center, Houston (N.P., M.D., H.M.K., M.K.); Dana-Farber Cancer Institute (A.A.L.) and Boston University School of Medicine (J.M.S.), Boston, and Veristat, Southborough (J.B.) - all in Massachusetts; H. Lee Moffitt Cancer Center, Tampa, FL (K.L.S., J.E.L.); City of Hope National Medical Center, Duarte, CA (A.S.S.); Ohio State University, Columbus (S.V.); Winship Cancer Institute of Emory University, Atlanta (W.B.); Duke University Medical Center, Durham, NC (D.A.R.); and Roswell Park Comprehensive Cancer Center, Buffalo (E.S.W.), and Stemline Therapeutics, New York (S. Spence, S. Shemesh, C.L.B., I.B.) - both in New York.

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http://dx.doi.org/10.1056/NEJMoa1815105DOI Listing
April 2019

Myeloid cell leukemia-1 dependence in acute myeloid leukemia: a novel approach to patient therapy.

Oncotarget 2019 Feb 8;10(12):1250-1265. Epub 2019 Feb 8.

The University of Texas MD Anderson Cancer Center, Houston, Texas, USA.

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http://dx.doi.org/10.18632/oncotarget.26579DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6383813PMC
February 2019

More on Blastic Plasmacytoid Dendritic-Cell Neoplasms.

N Engl J Med 2019 02;380(7):695-6

Dana–Farber Cancer Institute, Boston, MA

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http://dx.doi.org/10.1056/NEJMc1814963DOI Listing
February 2019

Assessment of l-Asparaginase Pharmacodynamics in Mouse Models of Cancer.

Metabolites 2019 Jan 9;9(1). Epub 2019 Jan 9.

Department of Bioinformatics and Computational Biology and The Proteomics and Metabolomics Core Facility, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.

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http://dx.doi.org/10.3390/metabo9010010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6359345PMC
January 2019

Refining statistics clarifies leukaemic stem cell genomics.

Br J Haematol 2019 06 26;185(5):1005-1007. Epub 2018 Nov 26.

Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.

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http://dx.doi.org/10.1111/bjh.15697DOI Listing
June 2019