Marina Cuchel

Marina Cuchel

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Marina Cuchel

Marina Cuchel

Publications by authors named "Marina Cuchel"

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JCL roundtable: High-density lipoprotein function and reverse cholesterol transport.

J Clin Lipidol 2018 Sep - Oct;12(5):1086-1094. Epub 2018 Oct 9.

Division of Endocrinology, Metabolism, and Nutrition, Department of Medicine, Duke University Medical Center, Durham, NC, USA. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S19332874183038
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http://dx.doi.org/10.1016/j.jacl.2018.09.005DOI Listing
October 2018

Is Low-Density Lipoprotein Cholesterol the Key to Interpret the Role of Lecithin:Cholesterol Acyltransferase in Atherosclerosis?

Circulation 2018 09;138(10):1008-1011

Division of Translational Medicine and Human Genetics, Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia (C.V., M.C.).

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https://www.ahajournals.org/doi/10.1161/CIRCULATIONAHA.118.0
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http://dx.doi.org/10.1161/CIRCULATIONAHA.118.035358DOI Listing
September 2018

Paradoxical coronary artery disease in humans with hyperalphalipoproteinemia is associated with distinct differences in the high-density lipoprotein phosphosphingolipidome.

J Clin Lipidol 2017 Sep - Oct;11(5):1192-1200.e3. Epub 2017 Jul 8.

Division of Translational Medicine and Human Genetics, Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA. Electronic address:

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http://dx.doi.org/10.1016/j.jacl.2017.06.018DOI Listing
May 2018

Cholesterol metabolism in humans: a review of methods and comparison of results.

Curr Opin Lipidol 2018 02;29(1):1-9

Division of Translational Medicine and Human Genetics, Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.

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http://dx.doi.org/10.1097/MOL.0000000000000475DOI Listing
February 2018

Long-Term Efficacy and Safety of the Microsomal Triglyceride Transfer Protein Inhibitor Lomitapide in Patients With Homozygous Familial Hypercholesterolemia.

Circulation 2017 07;136(3):332-335

From University of Cape Town, South Africa (D.J.B.); Università di Palermo, Italy (M.R.A.); University of Pennsylvania, Philadelphia (E.A.M., D.J.R. M.C.); Netcare Private Hospital, Bloemfontein, South Africa (H.d.T.T.); Ospedale Niguarda, Milano, Italy (R.A.H.); University of Western Ontario, London, Canada (R.A.H.); Cedars-Sinai Heart Institute, Los Angeles, CA (P.K.S.); Université de Montreal, Chicoutimi, Quebec, Canada (D.G.); Università di Roma Sapienza, Italy (C.S.); Università di Ferrara, Italy (G.B.V.); CHRU Montpellier, France (D.L.); and Aegerion Pharmaceuticals, Cambridge, MA (L.T.B., P.F.).

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http://dx.doi.org/10.1161/CIRCULATIONAHA.117.028208DOI Listing
July 2017

Lack of MTTP Activity in Pluripotent Stem Cell-Derived Hepatocytes and Cardiomyocytes Abolishes apoB Secretion and Increases Cell Stress.

Cell Rep 2017 05;19(7):1456-1466

Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA; Department of Cell and Developmental Biology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA; Institute for Regenerative Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA; Cardiovascular Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2017.04.064DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5555078PMC
May 2017

ATP-Binding Cassette Transporter A1 Deficiency in Human Induced Pluripotent Stem Cell-Derived Hepatocytes Abrogates HDL Biogenesis and Enhances Triglyceride Secretion.

EBioMedicine 2017 Apr 14;18:139-145. Epub 2017 Mar 14.

Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA; Department of Genetics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA; Institute for Translational Medicine and Therapeutics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA; Department of Pediatrics, Perelman School of Medicine of the University of Pennsylvania and Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA. Electronic address:

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http://dx.doi.org/10.1016/j.ebiom.2017.03.018DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5405159PMC
April 2017

Recent Developments in Gene Therapy for Homozygous Familial Hypercholesterolemia.

Curr Atheroscler Rep 2016 May;18(5):22

Department of Medicine, Division of Translational Medicine and Human Genetics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.

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http://dx.doi.org/10.1007/s11883-016-0579-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5609810PMC
May 2016

Long-term clinical results of microsomal triglyceride transfer protein inhibitor use in a patient with homozygous familial hypercholesterolemia.

J Clin Lipidol 2015 Jan-Feb;9(1):107-12. Epub 2014 Aug 23.

Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA. Electronic address:

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http://dx.doi.org/10.1016/j.jacl.2014.08.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4563802PMC
October 2015

ApoA-I-Directed Therapies for the Management of Atherosclerosis.

Curr Atheroscler Rep 2015 Oct;17(10):60

Division of Translational Medicine and Human Genetics, Perelman School of Medicine at the University of Pennsylvania, 3400 Civic Center Blvd, Room 11-132, Philadelphia, PA, 19104, USA,

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http://dx.doi.org/10.1007/s11883-015-0539-0DOI Listing
October 2015

Microsomal Triglyceride Transfer Protein Transfers and Determines Plasma Concentrations of Ceramide and Sphingomyelin but Not Glycosylceramide.

J Biol Chem 2015 Oct 8;290(43):25863-75. Epub 2015 Sep 8.

From the Departments of Cell Biology and Pediatrics, State University of New York Downstate Medical Center, Brooklyn, New York 11203, the Department of Veterans Affairs New York Harbor Healthcare System, Brooklyn, New York 11209

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http://dx.doi.org/10.1074/jbc.M115.659110DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4646243PMC
October 2015

ABCA1 and Inflammation: From Animal Models to Humans.

Arterioscler Thromb Vasc Biol 2015 Jul;35(7):1551-3

From the Division of Translational Medicine and Human Genetics, Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia.

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https://www.ahajournals.org/doi/10.1161/ATVBAHA.115.305547
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http://dx.doi.org/10.1161/ATVBAHA.115.305547DOI Listing
July 2015

High-Density Lipoprotein (HDL) Phospholipid Content and Cholesterol Efflux Capacity Are Reduced in Patients With Very High HDL Cholesterol and Coronary Disease.

Arterioscler Thromb Vasc Biol 2015 Jun 2;35(6):1515-9. Epub 2015 Apr 2.

From the Division of Translational Medicine and Human Genetics, Perelman School of Medicine, University of Pennsylvania, Philadelphia.

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http://dx.doi.org/10.1161/ATVBAHA.115.305504DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4560933PMC
June 2015

Functional analysis and transcriptomic profiling of iPSC-derived macrophages and their application in modeling Mendelian disease.

Circ Res 2015 Jun 22;117(1):17-28. Epub 2015 Apr 22.

From the Cardiovascular Institute (H.Z., C.X., R.S., K.B., C.C.H., W.L., A.R., J.T.-M., E.E.P., E.E.M., D.J.R., M.P.R.), and Department of Biostatistics and Epidemiology (M.L.), Perelman School of Medicine, Institute for Translational Medicine and Therapeutics, Institute for Diabetes, Obesity, and Metabolism (A.R., M.C., E.E.P., D.J.R.), Department of Medicine, Metabolic Tracer Resource, Institute for Diabetes, Obesity, and Metabolism (J.S.M.), Institute for Regenerative Medicine (Y.L., R.Y., W.Y., E.E.M.), Department of Biology, Perelman School of Medicine and School of Arts and Science (S.J.G., B.D.G.), PENN Genome Frontiers Institute (S.J.G., B.D.G.), Department of Pediatrics, Perelman School of Medicine (S.T.C.), Department of Cell and Developmental Biology, Perelman School of Medicine (E.E.M.), and Department of Biostatistics and Epidemiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia; and Division of Hematology, The Children's Hospital of Philadelphia, PA (D.V., S.T.C.).

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http://dx.doi.org/10.1161/CIRCRESAHA.117.305860DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4565503PMC
June 2015

Loss-of-function mutations in ABCA1 and enhanced β-cell secretory capacity in young adults.

Diabetes 2015 Jan 14;64(1):193-9. Epub 2014 Aug 14.

Division of Translational Medicine and Human Genetics, Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA

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http://diabetes.diabetesjournals.org/lookup/doi/10.2337/db14
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http://dx.doi.org/10.2337/db14-0436DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4274805PMC
January 2015

High-density lipoproteins: a consensus statement from the National Lipid Association.

J Clin Lipidol 2013 Sep-Oct;7(5):484-525. Epub 2013 Aug 11.

CGH Medical Center, Sterling, IL 61081, USA; University of Illinois School of Medicine, Peoria, IL, USA; Michigan State University College of Osteopathic Medicine, East Lansing, MI, USA. Electronic address:

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http://dx.doi.org/10.1016/j.jacl.2013.08.001DOI Listing
October 2014

Reconstituted high-density lipoprotein therapies: a cause for optimism.

Arterioscler Thromb Vasc Biol 2014 Sep;34(9):1800-2

From the Division of Cardiovascular Medicine (A.J., D.M.K.) and Division of Translational Medicine and Human Genetics (M.C.), Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia.

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http://dx.doi.org/10.1161/ATVBAHA.114.304156DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4560112PMC
September 2014

Clinical experience of lomitapide therapy in patients with homozygous familial hypercholesterolaemia.

Atheroscler Suppl 2014 Sep;15(2):33-45

Università di Palermo, Palermo, Italy.

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http://dx.doi.org/10.1016/j.atherosclerosissup.2014.07.005DOI Listing
September 2014

A novel ApoA-I truncation (ApoA-IMytilene) associated with decreased ApoA-I production.

Atherosclerosis 2014 Aug 2;235(2):470-6. Epub 2014 Jun 2.

Cardiovascular Nutrition Laboratory, Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University, 711 Washington Street, Boston, MA 02111, USA; Boston Heart Diagnostics, Framingham, MA 01702, USA. Electronic address:

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http://dx.doi.org/10.1016/j.atherosclerosis.2014.05.935DOI Listing
August 2014

Monogenic causes of elevated HDL cholesterol and implications for development of new therapeutics.

Clin Lipidol 2013 Dec;8(6):635-648

Division of Translational Medicine & Human Genetics, Department of Medicine, Perelman School of Medicine at the University of Pennsylvania, PA, USA ; 11-125 Smilow Center for Translational Research, 3400 Civic Center Boulevard, Building 421, PA 19104-5158, USA.

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http://dx.doi.org/10.2217/clp.13.73DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4217288PMC
December 2013

Microsomal transfer protein inhibition in humans.

Curr Opin Lipidol 2013 Jun;24(3):246-50

Department of Medicine, Division of Translational Medicine and Human Genetics, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA.

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http://content.wkhealth.com/linkback/openurl?sid=WKPTLP:land
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http://dx.doi.org/10.1097/MOL.0b013e32836139dfDOI Listing
June 2013

Treatment of familial hypercholesterolemia: is there a need beyond statin therapy?

Curr Atheroscler Rep 2012 Feb;14(1):11-6

Institute of Translational Medicine and Therapeutics, University of Pennsylvania School of Medicine, 3600 Spruce Street, Philadelphia, PA 19104, USA.

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http://dx.doi.org/10.1007/s11883-011-0215-yDOI Listing
February 2012

The ability to promote efflux via ABCA1 determines the capacity of serum specimens with similar high-density lipoprotein cholesterol to remove cholesterol from macrophages.

Arterioscler Thromb Vasc Biol 2010 Apr 14;30(4):796-801. Epub 2010 Jan 14.

Division of Gastroenterology, Hepatology and Nutrition, The Children's Hospital of Philadelphia, 3615 Civic Center Blvd, Philadelphia, PA 19104, USA.

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https://www.ahajournals.org/doi/10.1161/ATVBAHA.109.199158
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http://dx.doi.org/10.1161/ATVBAHA.109.199158DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2866499PMC
April 2010

Pathways by which reconstituted high-density lipoprotein mobilizes free cholesterol from whole body and from macrophages.

Arterioscler Thromb Vasc Biol 2010 Mar 17;30(3):526-32. Epub 2009 Dec 17.

Institute for Translational Medicine and Therapeutics, University of Pennsylvania School of Medicine, Maloney Building, Room 8039, 3600 Spruce Street, Philadelphia, PA 19104, USA.

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http://dx.doi.org/10.1161/ATVBAHA.109.196105DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2842952PMC
March 2010

Inflammation induces fibrinogen nitration in experimental human endotoxemia.

Free Radic Biol Med 2009 Oct 22;47(8):1140-6. Epub 2009 Jul 22.

Cardiovascular Institute, Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA.

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http://dx.doi.org/10.1016/j.freeradbiomed.2009.07.025DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3651370PMC
October 2009

Macrophage reverse cholesterol transport: key to the regression of atherosclerosis?

Circulation 2006 May;113(21):2548-55

Institute for Translational Medicine and Therapeutics, Cardiovascular Institute, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA.

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http://dx.doi.org/10.1161/CIRCULATIONAHA.104.475715DOI Listing
May 2006

The frequency of the cholesteryl ester transfer protein-TaqI B2 allele is lower in African Americans than in Caucasians.

Atherosclerosis 2002 Jul;163(1):169-74

Department of Medicine, University of Pennsylvania, School of Medicine, 654 BRB II/III, 421 Curie Blvd, Philadelphia, PA 19104, USA.

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http://dx.doi.org/10.1016/s0021-9150(01)00769-9DOI Listing
July 2002

The role of high density lipoproteins in thrombosis.

ScientificWorldJournal 2002 Jan 12;2:89-95. Epub 2002 Jan 12.

University of Pennsylvania School of Medicine, Department of Medicine, Philadelphia, USA.

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http://dx.doi.org/10.1100/tsw.2002.85DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6009396PMC
January 2002