Publications by authors named "Mariko Kitajima"

85Publications

Asymmetric Total Synthesis of Biphenylquinolizidine Alkaloids 4″--Demethyllythridine and 14--4″--Demethyllythridine.

Org Lett 2019 10 16;21(19):7982-7986. Epub 2019 Sep 16.

Graduate School of Pharmaceutical Sciences , Chiba University , 1-8-1 Inohana , Chuo-ku, Chiba 260-8675 , Japan.

View Article and Find Full Text PDF
October 2019

Total Synthesis of (-)-14-Hydroxygelsenicine and Six Biogenetically Related Alkaloids.

Org Lett 2019 09 12;21(17):7134-7137. Epub 2019 Aug 12.

Graduate School of Pharmaceutical Sciences, Chiba University, 1-8-1 Inohana, Chuo-ku, Chiba 260-8675, Japan.

View Article and Find Full Text PDF
September 2019

Total Syntheses of Pleiocarpamine, Normavacurine, and C-Mavacurine.

Org Lett 2019 05 18;21(9):3342-3345. Epub 2019 Apr 18.

Graduate School of Pharmaceutical Sciences , Chiba University , 1-8-1 Inohana, Chuo-ku , Chiba 260-8675 , Japan.

View Article and Find Full Text PDF
May 2019

Asymmetric Total Synthesis of Fawcettimine-Type Lycopodium Alkaloid, Lycopoclavamine-A.

J Org Chem 2019 05 9;84(9):5645-5654. Epub 2019 Apr 9.

Graduate School of Pharmaceutical Sciences , Chiba University , 1-8-1 Inohana , Chuo-ku, Chiba 260-8675 , Japan.

View Article and Find Full Text PDF
May 2019

New otonecine-type pyrrolizidine alkaloid from Petasites japonicus.

J Nat Med 2019 Jun 19;73(3):602-607. Epub 2019 Feb 19.

Graduate School of Pharmaceutical Sciences, Chiba University, 1-8-1 Inohana, Chuo-ku, Chiba, 260-8675, Japan.

View Article and Find Full Text PDF
June 2019

Asymmetric Total Synthesis and Evaluation of Antitumor Activity of Ophiorrhisine A and Its Derivatives.

J Org Chem 2018 12 4;83(24):15312-15322. Epub 2018 Dec 4.

Department of Biofunctional Molecular Chemistry, Graduate School of Pharmaceutical Sciences , Chiba University , 1-8-1 Inohana , Chuo-ku , Chiba 260-8675 , Japan.

View Article and Find Full Text PDF
December 2018

A Cyclopeptide and a Tetrahydroisoquinoline Alkaloid from Ophiorrhiza nutans.

J Nat Prod 2017 07 20;80(7):2156-2160. Epub 2017 Jul 20.

Department of Biofunctional Molecular Chemistry, Graduate School of Pharmaceutical Sciences, Chiba University , 1-8-1 Inohana, Chuo-ku, Chiba 260-8675, Japan.

View Article and Find Full Text PDF
July 2017

Asymmetric Total Synthesis of Pentacyclic Indole Alkaloid Andranginine and Absolute Configuration of Natural Product Isolated from Kopsia arborea.

Org Lett 2017 05 8;19(10):2722-2725. Epub 2017 May 8.

Graduate School of Pharmaceutical Sciences, Chiba University , 1-8-1 Inohana, Chuo-ku, Chiba 260-8675, Japan.

View Article and Find Full Text PDF
May 2017

Asymmetric Total Synthesis of Kopsiyunnanine K, a Monoterpenoid Indole Alkaloid with a Rearranged Skeleton.

Org Lett 2016 07 29;18(14):3490-3. Epub 2016 Jun 29.

Graduate School of Pharmaceutical Sciences, Chiba University , 1-8-1 Inohana, Chuo-ku, Chiba 260-8675, Japan.

View Article and Find Full Text PDF
July 2016

Asymmetric Total Synthesis of Sarpagine-Related Indole Alkaloids Hydroxygardnerine, Hydroxygardnutine, Gardnerine, (E)-16-epi-Normacusine B, and Koumine.

Org Lett 2016 Apr 1;18(8):1912-5. Epub 2016 Apr 1.

Graduate School of Pharmaceutical Sciences, Chiba University , 1-8-1 Inohana, Chuo-ku, Chiba 260-8675, Japan.

View Article and Find Full Text PDF
April 2016

New Lycopodine-Type Alkaloids from Lycopodium carinatum.

Chem Pharm Bull (Tokyo) 2016 Jul 25;64(7):793-9. Epub 2016 Mar 25.

Graduate School of Pharmaceutical Sciences, Chiba University.

View Article and Find Full Text PDF
July 2016

Monoterpenoid Bisindole Alkaloids.

Alkaloids Chem Biol 2016 21;76:259-310. Epub 2015 Oct 21.

Graduate School of Pharmaceutical Sciences, Chiba University, Chiba, Japan.

View Article and Find Full Text PDF
July 2016

Boosting Sensitivity in Liquid Chromatography-Fourier Transform Ion Cyclotron Resonance-Tandem Mass Spectrometry for Product Ion Analysis of Monoterpene Indole Alkaloids.

Front Plant Sci 2015 17;6:1127. Epub 2015 Dec 17.

RIKEN Center for Sustainable Resource ScienceYokohama, Japan; Graduate School of Pharmaceutical Sciences, Chiba UniversityChiba, Japan.

View Article and Find Full Text PDF
January 2016

The first asymmetric total synthesis of lycoposerramine-R.

Org Biomol Chem 2015 Jul;13(28):7762-71

Graduate School of Pharmaceutical Sciences, Chiba University, 1-8-1 Inohana, Chuo-ku, Chiba 260-8675, Japan.

View Article and Find Full Text PDF
July 2015

Asymmetric total synthesis of novel pentacyclic indole alkaloid, kopsiyunnanine E, isolated from Kopsia arborea.

Org Lett 2014 Oct 24;16(19):5000-3. Epub 2014 Sep 24.

Graduate School of Pharmaceutical Sciences, Chiba University , 1-8-1 Inohana, Chuo-ku, Chiba 260-8675, Japan.

View Article and Find Full Text PDF
October 2014

Biogenetically inspired total syntheses of Lycopodium alkaloids, (+)-flabellidine and (-)-lycodine.

J Am Chem Soc 2014 Aug 11;136(33):11618-21. Epub 2014 Aug 11.

Graduate School of Pharmaceutical Sciences, Chiba University , 1-8-1 Inohana, Chuo-ku, Chiba 260-8675, Japan.

View Article and Find Full Text PDF
August 2014

Identification of Indole Alkaloid Structural Units Important for Stimulus-Selective TRPM8 Inhibition: SAR Study of Naturally Occurring Iboga Derivatives.

J Nat Prod 2014 Aug;77(8):1831-8

Graduate School of Nutritional and Environmental Sciences, University of Shizuoka , 52-1 Yada, Suruga-ku, Shizuoka 422-8526, Japan.

View Article and Find Full Text PDF
August 2014

Orally active opioid μ/δ dual agonist MGM-16, a derivative of the indole alkaloid mitragynine, exhibits potent antiallodynic effect on neuropathic pain in mice.

J Pharmacol Exp Ther 2014 Mar 17;348(3):383-92. Epub 2013 Dec 17.

Laboratory of Pharmacology, Faculty of Pharmaceutical Sciences, Josai International University, Chiba, Japan (K.Ma., N.M., K.T., S.H.); Department of Toxicology (K.Ma., M.N., T.S.) and Department of Pharmacology (K.Ma., M.N.), Hoshi University School of Pharmacy and Pharmaceutical Sciences, Tokyo, Japan; Department of Molecular Structure and Biological Function, Graduate School of Pharmaceutical Sciences, Chiba University, Chiba, Japan (T.N., K.Mi., M.K., H.T.); and Department of Pharmacology and Systems Therapeutics, Mount Sinai School of Medicine, New York, New York (L.A.D.).

View Article and Find Full Text PDF
March 2014

Asymmetric total synthesis of an iboga-type indole alkaloid, voacangalactone, newly isolated from Voacanga africana.

Org Lett 2012 Nov 6;14(22):5800-3. Epub 2012 Nov 6.

Graduate School of Pharmaceutical Sciences, Chiba University, 1-8-1 Inohana, Chiba 260-8675, Japan.

View Article and Find Full Text PDF
November 2012

Two new alkaloids from Crinum asiaticum var. sinicum.

Chem Pharm Bull (Tokyo) 2011 ;59(12):1545-8

Graduate School of Pharmaceutical Sciences, Chiba University, Chiba 260–8675, Japan.

View Article and Find Full Text PDF
March 2012

Asymmetric total synthesis of a pentacyclic Lycopodium alkaloid: huperzine-Q.

Angew Chem Int Ed Engl 2011 Aug 12;50(35):8025-8. Epub 2011 Jul 12.

Graduate School of Pharmaceutical Sciences, Chiba University, Yayoi-cho, Inage-ku, Chiba, Japan.

View Article and Find Full Text PDF
August 2011

Lycopodium alkaloids: isolation and asymmetric synthesis.

Top Curr Chem 2012 ;309:1-31

Graduate School of Pharmaceutical Sciences, Chiba University, 1-33 Yayoi-cho, Inage-ku, Chiba 263-8522, Japan.

View Article and Find Full Text PDF
April 2012

Discovery of indole alkaloids with cannabinoid CB1 receptor antagonistic activity.

Bioorg Med Chem Lett 2011 Apr 13;21(7):1962-4. Epub 2011 Feb 13.

Graduate School of Pharmaceutical Sciences, Chiba University, 1-33 Yayoi-cho, Inage-ku, Chiba 263-8522, Japan.

View Article and Find Full Text PDF
April 2011

Inhibitory effect of Iboga-type indole alkaloids on capsaicin-induced contraction in isolated mouse rectum.

J Nat Med 2011 Jan 2;65(1):157-65. Epub 2010 Nov 2.

Department of Biofunctional Molecular Chemistry, Graduate School of Pharmaceutical Sciences, Chiba University, 1-33 Yayoi-cho, Inage-ku, Chiba 263-8522, Japan.

View Article and Find Full Text PDF
January 2011

Seven new monoterpenoid indole alkaloids from Gelsemium elegans.

Chem Asian J 2011 Jan;6(1):166-73

Graduate School of Pharmaceutical Sciences, Chiba University, 1-33 Yayoi-cho, Inage-ku, Chiba 263-8522, Japan.

View Article and Find Full Text PDF
January 2011

Isolation of pandamarilactonine-H from the roots of Pandanus amaryllifolius and synthesis of epi-pandamarilactonine-H.

J Nat Prod 2010 Aug;73(8):1453-5

Graduate School of Pharmaceutical Sciences, Chiba University, 1-33 Yayoi-cho, Inage-ku, Chiba 263-8522, Japan.

View Article and Find Full Text PDF
August 2010

Two new aspidosperma indole alkaloids from Yunnan Kopsia arborea.

Chem Pharm Bull (Tokyo) 2010 Jul;58(7):961-3

Graduate School of Pharmaceutical Sciences, Chiba University, Chiba, Japan.

View Article and Find Full Text PDF
July 2010

Amides, triterpene and flavonoids from the leaves of Melastoma malabathricum L.

J Nat Med 2010 Oct 26;64(4):492-5. Epub 2010 Jun 26.

Department of Chemistry, Faculty of Science, Universiti Teknologi Malaysia, 81310, Skudai, Johor, Malaysia.

View Article and Find Full Text PDF
October 2010

Determination of absolute configuration of trimeric indole alkaloid, psychotrimine, by first asymmetric total synthesis.

Chem Commun (Camb) 2010 Apr 1;46(14):2501-3. Epub 2010 Feb 1.

Graduate School of Pharmaceutical Sciences, Chiba University, 1-33 Yayoi-cho, Inage-ku, Chiba 263-8522, Japan.

View Article and Find Full Text PDF
April 2010

Asymmetric total syntheses of cyclic nitrone-containing phlegmarine-type Lycopodium alkaloids, lycoposerramines-X and -Z.

J Org Chem 2009 Nov;74(22):8675-80

Graduate School of Pharmaceutical Sciences, Chiba University, 1-33 Yayoi-cho, Inage-ku, Chiba 263-8522, Japan.

View Article and Find Full Text PDF
November 2009

First asymmetric total syntheses of fawcettimine-type Lycopodium alkaloids, lycoposerramine-C and phlegmariurine-A.

Org Lett 2009 Dec;11(23):5554-7

Graduate School of Pharmaceutical Sciences, Chiba University, 1-33 Yayoi-cho, Inage-ku, Chiba 263-8522, Japan.

View Article and Find Full Text PDF
December 2009

Kopsiyunnanines F and isocondylocarpines: new tubotaiwine-type alkaloids from Yunnan Kopsia arborea.

J Nat Med 2009 Jul 28;63(3):283-9. Epub 2009 Apr 28.

Graduate School of Pharmaceutical Sciences, Chiba University, 1-33 Yayoi-cho, Inage-ku, Chiba, 263-8522, Japan.

View Article and Find Full Text PDF
July 2009

Rhazinilam and quebrachamine derivatives from Yunnan Kopsia arborea.

J Nat Prod 2009 Feb;72(2):204-9

Graduate School of Pharmaceutical Sciences, Chiba University, 1-33 Yayoi-cho, Inage-ku, Chiba 263-8522, Japan.

View Article and Find Full Text PDF
February 2009

New lycorine-type alkaloid from Lycoris traubii and evaluation of antitrypanosomal and antimalarial activities of lycorine derivatives.

Bioorg Med Chem 2008 Dec 30;16(24):10182-9. Epub 2008 Oct 30.

Graduate School of Pharmaceutical Sciences, Chiba University, 1-33 Yayoi-cho, Inage-ku, Chiba 263-8522, Japan.

View Article and Find Full Text PDF
December 2008

New iridoids from Gelsemium species.

Chem Pharm Bull (Tokyo) 2008 Jun;56(6):870-2

Graduate School of Pharmaceutical Sciences, Chiba University, Japan.

View Article and Find Full Text PDF
June 2008

First asymmetric total syntheses of cernuane-type Lycopodium alkaloids, cernuine, and cermizine D.

Org Lett 2008 May 23;10(10):1987-90. Epub 2008 Apr 23.

Graduate School of Pharmaceutical Sciences, Chiba University, 1-33 Yayoi-cho, Inage-ku, Chiba 263-8522, Japan.

View Article and Find Full Text PDF
May 2008

Flavonols from Bauhinia malabarica.

J Nat Med 2008 Jul 15;62(3):364-5. Epub 2008 Apr 15.

Faculty of Pharmaceutical Sciences, Ubon Ratchatani University, Warinchamrap, Ubon Ratchathani Province, 34190, Thailand.

View Article and Find Full Text PDF
July 2008

Antitubercular triterpenes and phytosterols from Pandanus tectorius Soland. var. laevis.

J Nat Med 2008 Apr 14;62(2):232-5. Epub 2007 Dec 14.

Research Center for the Natural Sciences, Graduate School and College of Science, University of Santo Tomas, España, 1015, Manila, Philippines.

View Article and Find Full Text PDF
April 2008

A new prenylated dihydrochalcone from the leaves of Artocarpus lowii.

J Nat Med 2008 Jul 13;62(3):321-4. Epub 2008 Feb 13.

Department of Chemistry, Faculty of Science, Universiti Teknologi Malaysia, UTM Skudai, 81310, Johor Bahru, Johor, Malaysia.

View Article and Find Full Text PDF
July 2008

First total synthesis of trimeric indole alkaloid, psychotrimine.

Org Lett 2008 Jan 11;10(1):125-8. Epub 2007 Dec 11.

Graduate School of Pharmaceutical Sciences, Chiba University, Chiba 263-8522, Japan.

View Article and Find Full Text PDF
January 2008

Asymmetric total syntheses of two phlegmarine-type alkaloids, lycoposerramines-V and -W, newly isolated from Lycopodium serratum.

Org Lett 2007 Sep 8;9(20):4069-72. Epub 2007 Sep 8.

Graduate School of Pharmaceutical Sciences, Chiba University, 1-33 Yayoi-cho, Inage-ku, Chiba 263-8522, Japan.

View Article and Find Full Text PDF
September 2007

Design, synthesis, and biological evaluation of tricyclic heterocycle-tetraamine conjugates as potent NMDA channel blockers.

Bioorg Med Chem Lett 2007 Sep 27;17(17):4729-32. Epub 2007 Jun 27.

Graduate School of Pharmaceutical Sciences, Chiba University, Chiba, Japan.

View Article and Find Full Text PDF
September 2007

Fawcettimine-related alkaloids from Lycopodium serratum.

J Nat Prod 2007 Jun 16;70(6):1024-8. Epub 2007 May 16.

Graduate School of Pharmaceutical Sciences, Chiba University, 1-33 Yayoi-cho, Inage-ku, Chiba 263-8522, Japan.

View Article and Find Full Text PDF
June 2007

Prenylated flavonoids and related compounds of the Indonesian Artocarpus (Moraceae).

J Nat Med 2006 Jul 25;60(3):161-184. Epub 2006 May 25.

Chemistry, School of Biomedical and Chemical Sciences, The University of Western Australia, Crawley, WA, 6909, Australia.

View Article and Find Full Text PDF
July 2006

Isolation of gelsedine-type indole alkaloids from Gelsemium elegans and evaluation of the cytotoxic activity of gelsemium alkaloids for A431 epidermoid carcinoma cells.

J Nat Prod 2006 Apr;69(4):715-8

Department of Molecular Structure and Biological Function, Graduate School of Pharmaceutical Sciences, Chiba University, 1-33 Yayoi-cho, Inage-ku, Chiba 263-8522, Japan.

View Article and Find Full Text PDF
April 2006

Camptothecins and two new monoterpene glucosides from Ophiorrhiza liukiuensis.

Chem Pharm Bull (Tokyo) 2005 Oct;53(10):1355-8

Graduate School of Pharmaceutical Sciences, Chiba University.

View Article and Find Full Text PDF
October 2005

Anthraquinones from Hedyotis capitellata.

Phytochemistry 2005 May;66(10):1141-7

Faculty of Applied Science, Universiti Teknologi MARA, 40450 Shah Alam, Selangor, Malaysia.

View Article and Find Full Text PDF
May 2005

New type of trimeric and pentameric indole alkaloids from Psychotria rostrata.

Org Lett 2004 Aug;6(17):2945-8

Graduate School of Pharmaceutical Sciences, Chiba University, Chiba 263-8522, Japan.

View Article and Find Full Text PDF
August 2004

A new 9-methoxyyohimbine-type indole alkaloid from Mitragyna africanus.

Chem Pharm Bull (Tokyo) 2004 Mar;52(3):359-61

Graduate School of Pharmaceutical Sciences, Chiba University, Chiba, Japan.

View Article and Find Full Text PDF
March 2004

Biosynthesis of camptothecin. In silico and in vivo tracer study from [1-13C]glucose.

Plant Physiol 2004 Jan 4;134(1):161-70. Epub 2003 Dec 4.

Graduate School of Pharmaceutical Sciences, Chiba University, 1-33 Yayoi-cho, Inage-ku, Chiba 263-8522, Japan.

View Article and Find Full Text PDF
January 2004

New oxindole alkaloids and iridoid from Carolina jasmine (Gelsemium sempervirens Ait. f.).

Chem Pharm Bull (Tokyo) 2003 Oct;51(10):1211-4

Graduate School of Pharmaceutical Sciences, Chiba University, Japan.

View Article and Find Full Text PDF
October 2003

Ten new Lycopodium alkaloids having the lycopodane skeleton isolated from Lycopodium serratum Thunb.

Chem Pharm Bull (Tokyo) 2003 Oct;51(10):1163-9

Graduate School of Pharmaceutical Sciences, Chiba University, Japan.

View Article and Find Full Text PDF
October 2003

Two oligostilbenes, cis- and trans-diptoindonesin B, from Dryobalanops oblongifolia.

Phytochemistry 2003 Aug;63(8):913-7

Natural Products Chemistry Group, Department of Chemistry, Institut Teknologi Bandung, Jalan Ganesha 10, 40132 Bandung, Indonesia.

View Article and Find Full Text PDF
August 2003

Structure reinvestigation of gelsemoxonine, a constituent of Gelsemium elegans, reveals a novel, azetidine-containing indole alkaloid.

Org Lett 2003 Jun;5(12):2075-8

Graduate School of Pharmaceutical Sciences and Chemical Analysis Center, Chiba University, 1-33 Yayoi-cho, Inage-ku, Chiba 263-8522, Japan.

View Article and Find Full Text PDF
June 2003

Metabolite profiling of alkaloids and strictosidine synthase activity in camptothecin producing plants.

Phytochemistry 2003 Feb;62(3):461-70

Graduate School of Pharmaceutical Sciences, Chiba University, 1-33 Yayoi-cho, Inage-ku, Chiba 263-8522, Japan.

View Article and Find Full Text PDF
February 2003

Two new nor-triterpene glycosides from peruvian "Uña de Gato" (Uncaria tomentosa).

J Nat Prod 2003 Feb;66(2):320-3

Graduate School of Pharmaceutical Sciences, Chiba University, 1-33 Yayoi-cho, Inage-ku, Chiba 263-8522, Japan.

View Article and Find Full Text PDF
February 2003

Artoindonesianin P, a new prenylated flavone with cytotoxic activity from Artocarpus lanceifolius.

Fitoterapia 2002 Dec;73(7-8):668-73

Department of Chemistry, Institut Teknologi Bandung, Jalan Ganeca 10, Bandung 40132, Indonesia.

View Article and Find Full Text PDF
December 2002

Rhynchophylline and isorhynchophylline inhibit NMDA receptors expressed in Xenopus oocytes.

Eur J Pharmacol 2002 Nov;455(1):27-34

Department of Pharmacology, Institute of Natural Medicine, Toyama Medical and Pharmaceutical University, 2630 Sugitani, Toyama 930-0194, Japan.

View Article and Find Full Text PDF
November 2002

First total synthesis of a novel monoterpenoid isoquinoline alkaloid, (+/-)-alangine.

Chem Pharm Bull (Tokyo) 2002 Aug;50(8):1141-3

Graduate School of Pharmaceutical Sciences, Chiba University, Chiba, Japan.

View Article and Find Full Text PDF
August 2002

Pteropodine and isopteropodine positively modulate the function of rat muscarinic M(1) and 5-HT(2) receptors expressed in Xenopus oocyte.

Eur J Pharmacol 2002 May;444(1-2):39-45

Department of Pharmacology, Institute of Natural Medicine, Toyama Medical and Pharmaceutical University, 2630 Sugitani, Toyama, 930-0194, Japan.

View Article and Find Full Text PDF
May 2002

Novel biflavonoids from the stem bark of Ochna integerrima.

J Nat Prod 2002 Jul;65(7):1027-9

Department of Pharmacognosy, Faculty of Pharmaceutical Sciences, Chulalongkorn University, Bangkok 10330, Thailand.

View Article and Find Full Text PDF
July 2002

Isolation and Asymmetric Total Synthesis of a New Mitragyna Indole Alkaloid, (-)-Mitralactonine.

J Org Chem 1999 Mar;64(6):1772-1773

Faculty of Pharmaceutical Sciences, Chiba University, 1-33, Yayoi-cho, Inage-ku, Chiba 263-8522, Japan, and Chemistry Department, Universiti Kebangsaan Malaysia, 43600 Bangi, Selangor, Malaysia.

View Article and Find Full Text PDF
March 1999