Mariette R Boon

Mariette R Boon

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Mariette R Boon

Publications by authors named "Mariette R Boon"

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A single day of high fat diet feeding induces lipid accumulation and insulin resistance in brown adipose tissue in mice.

Am J Physiol Endocrinol Metab 2019 Aug 6. Epub 2019 Aug 6.

Department of Medicine, Division of Endocrinology, LUMC, Leiden, the Netherlands; Einthoven Laboratory for Experimental Vascular Medicine, LUMC, Leiden, Netherlands.

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http://dx.doi.org/10.1152/ajpendo.00123.2019DOI Listing
August 2019

Short-Term Cooling Increases Plasma ANGPTL3 and ANGPTL8 in Young Healthy Lean Men but Not in Middle-Aged Men with Overweight and Prediabetes.

J Clin Med 2019 Aug 14;8(8). Epub 2019 Aug 14.

Department of Medicine, Division of Endocrinology, Leiden University Medical Center, P.O. Box 9600, 2300 RC Leiden, The Netherlands.

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http://dx.doi.org/10.3390/jcm8081214DOI Listing
August 2019

Short-term cooling increases serum angiopoietin-like 4 levels in healthy lean men.

J Clin Lipidol 2018 Jan - Feb;12(1):56-61. Epub 2017 Nov 1.

Division of Endocrinology, Department of Medicine, Leiden University Medical Center, Leiden, The Netherlands; Einthoven Laboratory for Experimental Vascular Medicine, Leiden University Medical Center, Leiden, The Netherlands.

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http://dx.doi.org/10.1016/j.jacl.2017.10.016DOI Listing
July 2019

The Mediating Role of Brown Fat and Skeletal Muscle Measured by F-Fluorodeoxyglucose in the Thermoregulatory System in Young Adults.

Obesity (Silver Spring) 2019 Jun 21;27(6):963-970. Epub 2019 Apr 21.

Promoting Fitness & Health Through Physical Activity Research Group, Department of Physical Education and Sports, Faculty of Sport Sciences, University of Granada, Granada, Spain.

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http://dx.doi.org/10.1002/oby.22461DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6594074PMC
June 2019

Supraclavicular skin temperature measured by iButtons and F-fluorodeoxyglucose uptake by brown adipose tissue in adults.

J Therm Biol 2019 May 16;82:178-185. Epub 2019 Apr 16.

PROFITH (PROmoting FITness and Health through Physical Activity) Research Group, Department of Physical and Sports Education, Faculty of Sports Science, University of Granada, Granada, Spain.

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http://dx.doi.org/10.1016/j.jtherbio.2019.04.006DOI Listing
May 2019

Distribution of Brown Adipose Tissue Radiodensity in Young Adults: Implications for Cold [F]FDG-PET/CT Analyses.

Mol Imaging Biol 2019 May 30. Epub 2019 May 30.

PROFITH "PROmoting FITness and Health through physical activity" research group. Department of Physical Education and Sport, Faculty of Sport Sciences, University of Granada, Crta de Alfacar s/n, C.P. 18071, Granada, Spain.

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http://dx.doi.org/10.1007/s11307-019-01381-yDOI Listing
May 2019

Role of Human Brown Fat in Obesity, Metabolism and Cardiovascular Disease: Strategies to Turn Up the Heat.

Prog Cardiovasc Dis 2018 Jul - Aug;61(2):232-245. Epub 2018 Jul 4.

Department of Medicine, Division of Endocrinology, Einthoven Laboratory for Experimental Vascular Medicine, Leiden University Medical Center, Leiden, the Netherlands.

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http://dx.doi.org/10.1016/j.pcad.2018.07.002DOI Listing
November 2018

Gene Expression of Endocannabinoid System Components in Skeletal Muscle and Adipose Tissue of South Asians and White Caucasians with Overweight.

Obesity (Silver Spring) 2018 08 1;26(8):1332-1337. Epub 2018 Aug 1.

Department of Medicine, Division of Endocrinology Leiden University Medical Center, Leiden, the Netherlands.

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http://dx.doi.org/10.1002/oby.22245DOI Listing
August 2018

IL-37 Expression Reduces Lean Body Mass in Mice by Reducing Food Intake.

Int J Mol Sci 2018 Aug 2;19(8). Epub 2018 Aug 2.

Department of Medicine, Division of Endocrinology, Leiden University Medical Center, Post Zone C7Q, P.O. Box 9600, 2300 RC Leiden, The Netherlands.

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http://dx.doi.org/10.3390/ijms19082264DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6121375PMC
August 2018

The impact of using BARCIST 1.0 criteria on quantification of BAT volume and activity in three independent cohorts of adults.

Sci Rep 2018 Jun 4;8(1):8567. Epub 2018 Jun 4.

PROFITH "PROmoting FITness and Health through physical activity" research Group, Department of Physical Education and Sport, Faculty of Sport Sciences, University of Granada, Granada, Spain.

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http://dx.doi.org/10.1038/s41598-018-26878-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5986766PMC
June 2018

Quercetin Lowers Plasma Triglycerides Accompanied by White Adipose Tissue Browning in Diet-Induced Obese Mice.

Int J Mol Sci 2018 06 16;19(6). Epub 2018 Jun 16.

Department of Medicine, Division of Endocrinology, Leiden University Medical Center, Post Zone C7Q, P.O. Box 9600, 2300 RC Leiden, The Netherlands.

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http://dx.doi.org/10.3390/ijms19061786DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6032193PMC
June 2018

Short-term cooling increases serum triglycerides and small high-density lipoprotein levels in humans.

J Clin Lipidol 2017 Jul - Aug;11(4):920-928.e2. Epub 2017 May 3.

Division of Endocrinology, Department of Medicine, Leiden University Medical Center, Leiden, The Netherlands; Einthoven Laboratory for Experimental Vascular Medicine, Leiden University Medical Center, Leiden, The Netherlands.

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http://dx.doi.org/10.1016/j.jacl.2017.04.117DOI Listing
February 2018

Targeting white, brown and perivascular adipose tissue in atherosclerosis development.

Eur J Pharmacol 2017 Dec 24;816:82-92. Epub 2017 Mar 24.

Einthoven Laboratory for Experimental Vascular Medicine, Leiden, The Netherlands; Department of Human Genetics, Leiden University Medical Center, Leiden, The Netherlands. Electronic address:

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http://dx.doi.org/10.1016/j.ejphar.2017.03.051DOI Listing
December 2017

South Asian men have lower expression of IFN signalling genes in white adipose tissue and skeletal muscle compared with white men.

Diabetologia 2017 12 8;60(12):2525-2528. Epub 2017 Sep 8.

Department of Medicine, Division of Endocrinology, post zone C7Q, Leiden University Medical Center, P.O. Box 9600, 2300 RC, Leiden, the Netherlands.

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http://dx.doi.org/10.1007/s00125-017-4427-8DOI Listing
December 2017

Atorvastatin accelerates clearance of lipoprotein remnants generated by activated brown fat to further reduce hypercholesterolemia and atherosclerosis.

Atherosclerosis 2017 Dec 26;267:116-126. Epub 2017 Oct 26.

Dept. of Medicine, Div. of Endocrinology, Leiden University Medical Center, Leiden, The Netherlands; Einthoven Laboratory for Experimental Vascular Medicine, Leiden University Medical Center, Leiden, The Netherlands.

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http://dx.doi.org/10.1016/j.atherosclerosis.2017.10.030DOI Listing
December 2017

A New Personalized Cooling Protocol to Activate Brown Adipose Tissue in Young Adults.

Front Physiol 2017 2;8:863. Epub 2017 Nov 2.

PROFITH (PROmoting FITness and Health through Physical Activity) Research Group, Department of Physical Education and Sport, Faculty of Sport Sciences, University of Granada, Granada, Spain.

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http://dx.doi.org/10.3389/fphys.2017.00863DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5673647PMC
November 2017

Helminth antigens counteract a rapid high-fat diet-induced decrease in adipose tissue eosinophils.

J Mol Endocrinol 2017 10 10;59(3):245-255. Epub 2017 Jul 10.

Department of Medical BiochemistryExperimental Vascular Biology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands

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http://dx.doi.org/10.1530/JME-17-0112DOI Listing
October 2017

Lower critical temperature and cold-induced thermogenesis of lean and overweight humans are inversely related to body mass and basal metabolic rate.

J Therm Biol 2017 Oct 12;69:238-248. Epub 2017 Aug 12.

Department of Medicine, Division of Endocrinology and Einthoven Laboratory for Experimental Vascular Medicine, Leiden University Medical Center, Albinusdreef 2, 2333 ZA Leiden, the Netherlands. Electronic address:

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http://dx.doi.org/10.1016/j.jtherbio.2017.08.006DOI Listing
October 2017

Differences between the most used equations in BAT-human studies to estimate parameters of skin temperature in young lean men.

Sci Rep 2017 09 5;7(1):10530. Epub 2017 Sep 5.

PROFITH "PROmoting FITness and Health through physical activity" research group. Department of Physical Education and Sport, Faculty of Sport Sciences, University of Granada, Granada, Spain.

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http://dx.doi.org/10.1038/s41598-017-10444-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5585347PMC
September 2017

Endocannabinoid tone is higher in healthy lean South Asian than white Caucasian men.

Sci Rep 2017 08 8;7(1):7558. Epub 2017 Aug 8.

Department of Medicine, Division of Endocrinology, Leiden University Medical Center, Albinusdreef 2, Leiden, 2333 ZA, The Netherlands.

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http://dx.doi.org/10.1038/s41598-017-07980-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5548787PMC
August 2017

Activation and quantification of human brown adipose tissue: Methodological considerations for between studies comparisons: Comment on: Hot heads & cool bodies: The conundrums of human BAT activity research.

Eur J Intern Med 2017 05 16;40:e19-e21. Epub 2017 Feb 16.

PROFITH "PROmoting FITness and Health through physical activity" Research Group, Department of Physical Education and Sport, Faculty of Sport Sciences, University of Granada, Spain.

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https://linkinghub.elsevier.com/retrieve/pii/S09536205173006
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http://dx.doi.org/10.1016/j.ejim.2017.02.006DOI Listing
May 2017

BCG lowers plasma cholesterol levels and delays atherosclerotic lesion progression in mice.

Atherosclerosis 2016 08 19;251:6-14. Epub 2016 May 19.

Dept. of Medicine, Div. of Endocrinology, Leiden University Medical Center, Leiden, The Netherlands; Einthoven Laboratory for Experimental Vascular Medicine, Leiden, The Netherlands.

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http://dx.doi.org/10.1016/j.atherosclerosis.2016.05.031DOI Listing
August 2016

Brown Adipose Tissue: A Human Perspective.

Handb Exp Pharmacol 2016 ;233:301-19

Maastricht University, Maastricht, The Netherlands.

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http://dx.doi.org/10.1007/164_2015_11DOI Listing
June 2016

Physiological changes due to mild cooling in healthy lean males of white Caucasian and South Asian descent: A metabolomics study.

Arch Biochem Biophys 2016 Jan 16;589:152-7. Epub 2015 Sep 16.

Department of Medicine, Division of Endocrinology, Leiden University Medical Center, Leiden, The Netherlands; Department of Clinical Epidemiology, Leiden University Medical Center, Leiden, The Netherlands; Epidemiology Section, BESC Department, King Faisal Specialist Hospital and Research Center, Riyadh, Saudi Arabia.

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http://dx.doi.org/10.1016/j.abb.2015.09.001DOI Listing
January 2016

Role of Brown Fat in Lipoprotein Metabolism and Atherosclerosis.

Circ Res 2016 Jan;118(1):173-82

From the Department of Medicine, Division of Endocrinology and Einthoven Laboratory for Experimental Vascular Medicine, Leiden University Medical Center, Leiden, The Netherlands.

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http://dx.doi.org/10.1161/CIRCRESAHA.115.306647DOI Listing
January 2016

Central GLP-1 receptor signalling accelerates plasma clearance of triacylglycerol and glucose by activating brown adipose tissue in mice.

Diabetologia 2015 Nov 9;58(11):2637-46. Epub 2015 Aug 9.

Department of Medicine, Division of Endocrinology, Leiden University Medical Center, Room C7-Q44, Albinusdreef 2, PO Box 9600, 2300, RC, Leiden, the Netherlands.

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http://dx.doi.org/10.1007/s00125-015-3727-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4589565PMC
November 2015

Salsalate attenuates diet induced non-alcoholic steatohepatitis in mice by decreasing lipogenic and inflammatory processes.

Br J Pharmacol 2015 Nov 22;172(22):5293-305. Epub 2015 Oct 22.

Department of Metabolic Health Research, The Netherlands Organization for Applied Scientific Research (TNO), Leiden, The Netherlands.

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http://doi.wiley.com/10.1111/bph.13315
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http://dx.doi.org/10.1111/bph.13315DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5341213PMC
November 2015

Smoking is associated with increased resting energy expenditure in the general population: The NEO study.

Metabolism 2015 Nov 18;64(11):1548-55. Epub 2015 Aug 18.

Department of Medicine, Division of Endocrinology, Leiden University Medical Center, PO Box 9600, 2300 RC Leiden, The Netherlands; Department of Epidemiology, Leiden University Medical Center, PO Box 9600, 2300 RC Leiden, The Netherlands; Department of Clinical Epidemiology, Aarhus University, DK-8000 Aarhus C, Denmark.

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https://linkinghub.elsevier.com/retrieve/pii/S00260495150022
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http://dx.doi.org/10.1016/j.metabol.2015.08.008DOI Listing
November 2015

Cold Exposure Partially Corrects Disturbances in Lipid Metabolism in a Male Mouse Model of Glucocorticoid Excess.

Endocrinology 2015 Nov 15;156(11):4115-28. Epub 2015 Sep 15.

Department of Internal Medicine (J.C.v.d.B., J.S., A.P.N.T., A.G.), Erasmus University Medical Center, 3000 CA Rotterdam, The Netherlands; Department of Medicine (M.R.B., P.C.N.R., O.C.M.), Division of Endocrinology, Leiden University Medical Center, 2300 RC Leiden, The Netherlands; and Einthoven Laboratory of Experimental Vascular Medicine (M.R.B., P.C.N.R., O.C.M.), Leiden University Medical Center, 2300 RC Leiden, The Netherlands.

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http://dx.doi.org/10.1210/en.2015-1092DOI Listing
November 2015

Supraclavicular skin temperature as a measure of 18F-FDG uptake by BAT in human subjects.

PLoS One 2014 12;9(6):e98822. Epub 2014 Jun 12.

Department of Endocrinology and Metabolic Diseases, Leiden University Medical Center, Leiden, The Netherlands; Einthoven Laboratory for Experimental Vascular Medicine, Leiden University Medical Center, Leiden, The Netherlands.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0098822PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4055666PMC
October 2015

Regulation of brown fat by AMP-activated protein kinase.

Trends Mol Med 2015 Sep 10;21(9):571-9. Epub 2015 Aug 10.

Department of Medicine, Division of Endocrinology and Einthoven Laboratory for Experimental Vascular Medicine, Leiden University Medical Center, post zone C7Q, PO Box 9600, 2300 RC Leiden, The Netherlands.

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http://dx.doi.org/10.1016/j.molmed.2015.07.003DOI Listing
September 2015

Cold acclimation affects immune composition in skeletal muscle of healthy lean subjects.

Physiol Rep 2015 Jul;3(7)

Department of Human Biology, NUTRIM, School for Nutrition, Toxicology and Metabolism, Maastricht University, Maastricht, The Netherlands.

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http://dx.doi.org/10.14814/phy2.12394DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4552515PMC
July 2015

Tracing human brown fat.

Nat Med 2015 Jul;21(7):667-8

Department of Human Biology and Movement Sciences, NUTRIM School of Nutrition and Translational Research in Metabolism, Maastricht University, Maastricht, The Netherlands.

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http://dx.doi.org/10.1038/nm.3900DOI Listing
July 2015

Salsalate activates brown adipose tissue in mice.

Diabetes 2015 May 4;64(5):1544-54. Epub 2014 Dec 4.

Department of Endocrinology and Metabolic Diseases, Leiden University Medical Center, Leiden, the Netherlands Einthoven Laboratory for Experimental Vascular Medicine, Leiden, the Netherlands.

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http://diabetes.diabetesjournals.org/content/64/5/1544.full.
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http://diabetes.diabetesjournals.org/content/early/2014/12/0
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http://diabetes.diabetesjournals.org/lookup/doi/10.2337/db14
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http://dx.doi.org/10.2337/db14-1125DOI Listing
May 2015

Brown fat activation reduces hypercholesterolaemia and protects from atherosclerosis development.

Nat Commun 2015 Mar 10;6:6356. Epub 2015 Mar 10.

1] Division of Endocrinology, Department of Medicine, Leiden University Medical Center, Albinusdreef 2, Leiden 2333 ZA, The Netherlands [2] Einthoven Laboratory for Experimental Vascular Medicine, Leiden University Medical Center, Albinusdreef 2, Leiden 2333 ZA, The Netherlands.

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http://dx.doi.org/10.1038/ncomms7356DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4366535PMC
March 2015

Brown adipose tissue takes up plasma triglycerides mostly after lipolysis.

J Lipid Res 2015 Jan 28;56(1):51-9. Epub 2014 Oct 28.

Department of Endocrinology, Leiden University Medical Center, Leiden, The Netherlands Einthoven Laboratory for Experimental Vascular Medicine, Leiden University Medical Center, Leiden, The Netherlands.

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http://dx.doi.org/10.1194/jlr.M052746DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4274071PMC
January 2015

Inhibition of the central melanocortin system decreases brown adipose tissue activity.

J Lipid Res 2014 Oct 12;55(10):2022-32. Epub 2014 Jul 12.

Department of Endocrinology and Metabolic Diseases, Leiden University Medical Center, Leiden, The Netherlands Einthoven Laboratory for Experimental Vascular Medicine, Leiden University Medical Center, Leiden, The Netherlands.

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http://www.jlr.org/content/early/2014/07/12/jlr.M045989.full
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http://www.jlr.org/content/55/10/2022.full.pdf
Web Search
http://www.jlr.org/cgi/doi/10.1194/jlr.M045989
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http://dx.doi.org/10.1194/jlr.M045989DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4173995PMC
October 2014

Effects of short-term nutritional interventions on right ventricular function in healthy men.

PLoS One 2013 23;8(9):e76406. Epub 2013 Sep 23.

Department of Radiology, Leiden University Medical Center, Leiden, the Netherlands ; Department of Endocrinology and Metabolism, Leiden University Medical Center, Leiden, the Netherlands.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0076406PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3781057PMC
July 2014

Fat cells gain new identities.

Sci Transl Med 2014 Jul;6(247):247fs29

Department of Human Biology, Maastricht University, P.O. Box 616; 6200MD Maastricht, the Netherlands.

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http://dx.doi.org/10.1126/scitranslmed.3009809DOI Listing
July 2014

BMP7 activates brown adipose tissue and reduces diet-induced obesity only at subthermoneutrality.

PLoS One 2013 16;8(9):e74083. Epub 2013 Sep 16.

Department of Endocrinology and Metabolic Diseases, Leiden University Medical Center, Leiden, The Netherlands ; Einthoven Laboratory for Experimental Vascular Medicine, Leiden University Medical Center, Leiden, The Netherlands.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0074083PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3774620PMC
May 2014

Metformin lowers plasma triglycerides by promoting VLDL-triglyceride clearance by brown adipose tissue in mice.

Diabetes 2014 Mar 22;63(3):880-91. Epub 2013 Nov 22.

Department of General Internal Medicine, Endocrinology, and Metabolic Diseases, Leiden University Medical Center, Leiden, the Netherlands.

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http://dx.doi.org/10.2337/db13-0194DOI Listing
March 2014

Brown adipose tissue volume in healthy lean south Asian adults compared with white Caucasians: a prospective, case-controlled observational study.

Lancet Diabetes Endocrinol 2014 Mar 12;2(3):210-7. Epub 2013 Nov 12.

Department of Endocrinology and Metabolic Diseases, Leiden University Medical Center, Leiden, Netherlands; Einthoven Laboratory for Experimental Vascular Medicine, Leiden University Medical Center, Leiden, Netherlands.

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https://linkinghub.elsevier.com/retrieve/pii/S22138587137015
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http://dx.doi.org/10.1016/S2213-8587(13)70156-6DOI Listing
March 2014

Impact of Metformin and compound C on NIS expression and iodine uptake in vitro and in vivo: a role for CRE in AMPK modulation of thyroid function.

Thyroid 2014 Jan 25;24(1):78-87. Epub 2013 Sep 25.

1 Department of Endocrinology and Metabolic Diseases, University Medical Center , Leiden, The Netherlands .

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http://dx.doi.org/10.1089/thy.2013.0041DOI Listing
January 2014

Glucocorticoid excess induces long-lasting changes in body composition in male C57Bl/6J mice only with high-fat diet.

Physiol Rep 2013 Oct 11;1(5):e00103. Epub 2013 Oct 11.

Department of Endocrinology and Metabolic Diseases, Leiden University Medical Center PO Box 9600, Leiden, 2300 RC, The Netherlands.

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http://dx.doi.org/10.1002/phy2.103DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3841039PMC
October 2013

[Brown adipose tissue: the body's own weapon against obesity?].

Ned Tijdschr Geneeskd 2013 ;157(20):A5502

Leids Universitair Medisch Centrum, Afd. Algemene Interne Geneeskunde, Leiden, the Netherlands.

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July 2013

Mast cells are the main interleukin 17-positive cells in anticitrullinated protein antibody-positive and -negative rheumatoid arthritis and osteoarthritis synovium.

Arthritis Res Ther 2011 20;13(5):R150. Epub 2011 Sep 20.

Department of Rheumatology, Leiden University Medical Center, PO Box 9600, Albinusdreef 2, C1-R, NL-2300 RC Leiden, The Netherlands.

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http://dx.doi.org/10.1186/ar3466DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3308080PMC
December 2012

Bone morphogenetic protein 7: a broad-spectrum growth factor with multiple target therapeutic potency.

Cytokine Growth Factor Rev 2011 Aug 15;22(4):221-9. Epub 2011 Sep 15.

Department of General Internal Medicine, Endocrinology and Metabolic Diseases, Leiden University Medical Center, Leiden, The Netherlands.

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http://dx.doi.org/10.1016/j.cytogfr.2011.08.001DOI Listing
August 2011