Marien I Jonge

Marien I de Jonge

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Marien I Jonge

Marien I de Jonge

Publications by authors named "Marien I de Jonge"

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1PubMed Central Citations

Nasopharyngeal microbiota profiles in rural Venezuelan children are associated with respiratory and gastrointestinal infections.

Clin Infect Dis 2020 Jan 10. Epub 2020 Jan 10.

Department of Pediatric Infectious Diseases and Immunology, Wilhelmina Children's Hospital, University Medical Center Utrecht, Utrecht, The Netherlands.

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http://dx.doi.org/10.1093/cid/ciaa015DOI Listing
January 2020

Immune recognition of putative alien microbial structures: Host-pathogen interactions in the age of space travel.

PLoS Pathog 2020 01 30;16(1):e1008153. Epub 2020 Jan 30.

Department of Laboratory Medicine and Radboud Center for Infectious Diseases, Radboud University Medical Center, Nijmegen, the Netherlands.

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http://dx.doi.org/10.1371/journal.ppat.1008153DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6991955PMC
January 2020

Intranasal Vaccination With Lipoproteins Confers Protection Against Pneumococcal Colonisation.

Front Immunol 2018 18;9:2405. Epub 2018 Oct 18.

Department of Molecular Genetics and Infection Biology, Center for Functional Genomics of Microbes, Interfaculty Institute of Genetics and Functional Genomics, University of Greifswald, Greifswald, Germany.

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https://www.frontiersin.org/article/10.3389/fimmu.2018.02405
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http://dx.doi.org/10.3389/fimmu.2018.02405DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6202950PMC
October 2019

Limited Innovations After More Than 65 Years of Immunoglobulin Replacement Therapy: Potential of IgA- and IgM-Enriched Formulations to Prevent Bacterial Respiratory Tract Infections.

Front Immunol 2018 23;9:1925. Epub 2018 Aug 23.

Section Pediatric Infectious Diseases, Laboratory of Medical Immunology, Radboud Institute for Molecular Life Sciences, Nijmegen, Netherlands.

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http://dx.doi.org/10.3389/fimmu.2018.01925DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6115500PMC
September 2019

Serum IgM and C-Reactive Protein Binding to Phosphorylcholine of Nontypeable Increases Complement-Mediated Killing.

Infect Immun 2019 08 23;87(8). Epub 2019 Jul 23.

Section Pediatric Infectious Diseases, Laboratory of Medical Immunology, Radboud Institute for Molecular Life Sciences, Radboud University Medical Center, Nijmegen, The Netherlands.

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http://dx.doi.org/10.1128/IAI.00299-19DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6652778PMC
August 2019

Biosynthetic homeostasis and resilience of the complement system in health and infectious disease.

EBioMedicine 2019 Jul 29;45:303-313. Epub 2019 Jun 29.

Section Pediatric Infectious Diseases, Laboratory of Medical Immunology, Department of Laboratory Medicine, Radboud Institute for Molecular Life Sciences, Radboud University Medical Center, Nijmegen, The Netherlands; Radboud Center for Infectious Diseases, Radboud University Medical Center, Nijmegen, The Netherlands.

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http://dx.doi.org/10.1016/j.ebiom.2019.06.008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6642076PMC
July 2019

Common Genetic Variants in the Complement System and their Potential Link with Disease Susceptibility and Outcome of Invasive Bacterial Infection.

J Innate Immun 2020 3;12(2):131-141. Epub 2019 Jul 3.

Section Paediatric Infectious Diseases, Laboratory of Medical Immunology, Radboud Institute for Molecular Life Sciences, Radboudumc, Nijmegen, The Netherlands,

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http://dx.doi.org/10.1159/000500545DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7098274PMC
July 2019

Uptake of Sialic Acid by Nontypeable Haemophilus influenzae Increases Complement Resistance through Decreasing IgM-Dependent Complement Activation.

Infect Immun 2019 06 21;87(6). Epub 2019 May 21.

Section Pediatric Infectious Diseases, Laboratory of Medical Immunology, Radboud Institute for Molecular Life Sciences, Radboud University Medical Center, Nijmegen, the Netherlands

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http://dx.doi.org/10.1128/IAI.00077-19DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6529651PMC
June 2019

Selective Inhibition of Sialic Acid-Based Molecular Mimicry in Haemophilus influenzae Abrogates Serum Resistance.

Cell Chem Biol 2018 10 5;25(10):1279-1285.e8. Epub 2018 Jul 5.

Cluster of Molecular Chemistry, Institute for Molecules and Materials, Radboud University, Nijmegen 6525 AJ, the Netherlands. Electronic address:

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http://dx.doi.org/10.1016/j.chembiol.2018.05.018DOI Listing
October 2018

Selective counting and sizing of single virus particles using fluorescent aptamer-based nanoparticle tracking analysis.

Nanoscale 2018 Aug 30;10(29):13942-13948. Epub 2018 May 30.

MTA-BME Lendület Chemical Nanosensors Research Group, Department of Inorganic and Analytical Chemistry, Budapest University of Technology and Economics, Szt. Gellert tér 4, H-1111 Budapest, Hungary.

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http://xlink.rsc.org/?DOI=C8NR01310A
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http://dx.doi.org/10.1039/c8nr01310aDOI Listing
August 2018

Adaptation of Bordetella pertussis to the Respiratory Tract.

J Infect Dis 2018 05;217(12):1987-1996

Section Pediatric Infectious Diseases, Laboratory of Medical Immunology, Radboud Institute for Molecular Life Sciences, Radboud University Medical Centre, Nijmegen, The Netherlands.

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http://dx.doi.org/10.1093/infdis/jiy125DOI Listing
May 2018

Siglec-1 inhibits RSV-induced interferon gamma production by adult T cells in contrast to newborn T cells.

Eur J Immunol 2018 04 18;48(4):621-631. Epub 2018 Jan 18.

Laboratory of Pediatric Infectious Diseases, Department of Pediatrics, Radboud Institute for Molecular Life Sciences, Radboud university medical center, Nijmegen, The Netherlands.

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http://doi.wiley.com/10.1002/eji.201747161
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http://dx.doi.org/10.1002/eji.201747161DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5947594PMC
April 2018

Streptococcus pneumoniae PspC Subgroup Prevalence in Invasive Disease and Differences in Contribution to Complement Evasion.

Infect Immun 2018 04 22;86(4). Epub 2018 Mar 22.

Section Pediatric Infectious Diseases, Laboratory of Medical Immunology, Radboud Institute for Molecular Life Sciences, Radboud University Medical Center, Nijmegen, The Netherlands

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http://dx.doi.org/10.1128/IAI.00010-18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5865030PMC
April 2018

For the greater good: Programmed cell death in bacterial communities.

Microbiol Res 2018 Mar 1;207:161-169. Epub 2017 Dec 1.

Section of Pediatric Infectious Diseases, Laboratory of Medical Immunology, Radboud Institute for Molecular Life Sciences, Radboud University Medical Center, Nijmegen, The Netherlands.

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http://dx.doi.org/10.1016/j.micres.2017.11.016DOI Listing
March 2018

IgM Augments Complement Bactericidal Activity with Serum from a Patient with a Novel CD79a Mutation.

J Clin Immunol 2018 02 15;38(2):185-192. Epub 2018 Jan 15.

Section Pediatric Infectious Diseases, Laboratory of Medical Immunology, Radboud Institute for Molecular Life Sciences, Radboud University Medical Center, Nijmegen, The Netherlands.

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http://dx.doi.org/10.1007/s10875-017-0474-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5840230PMC
February 2018

Haemophilus is overrepresented in the nasopharynx of infants hospitalized with RSV infection and associated with increased viral load and enhanced mucosal CXCL8 responses.

Microbiome 2018 01 11;6(1):10. Epub 2018 Jan 11.

Laboratory of Pediatric Infectious Diseases, Radboud Center for Infectious Diseases, Radboud University Medical Center, Geert Grooteplein-Zuid 10 (Route 412), 6525, GA, Nijmegen, The Netherlands.

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http://dx.doi.org/10.1186/s40168-017-0395-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5765694PMC
January 2018

Spleen-derived IFN-γ induces generation of PD-L1-suppressive neutrophils during endotoxemia.

J Leukoc Biol 2017 12 3;102(6):1401-1409. Epub 2017 Oct 3.

Radboud Center for Infectious Diseases (RCI), Nijmegen, The Netherlands; and

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http://doi.wiley.com/10.1189/jlb.3A0217-051RR
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http://dx.doi.org/10.1189/jlb.3A0217-051RRDOI Listing
December 2017

Platelets Modulate Innate Immune Response Against Human Respiratory Syncytial Virus In Vitro.

Viral Immunol 2017 10 7;30(8):576-581. Epub 2017 Aug 7.

3 Laboratory of Pediatric Infectious Diseases, Department of Pediatrics, Radboud University Medical Center , Radboud Center for Infectious Diseases, Nijmegen, the Netherlands .

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http://dx.doi.org/10.1089/vim.2016.0161DOI Listing
October 2017

A novel flow cytometry-based assay for the quantification of antibody-dependent pneumococcal agglutination.

PLoS One 2017 13;12(3):e0170884. Epub 2017 Mar 13.

Laboratory of Pediatric Infectious Diseases, Department of Pediatrics, Radboud Institute for Molecular Life Sciences, Radboud university medical center, Nijmegen, The Netherlands.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0170884PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5347990PMC
September 2017

Genetic background impacts vaccine-induced reduction of pneumococcal colonization.

Vaccine 2017 09 17;35(39):5235-5241. Epub 2017 Aug 17.

Laboratory of Pediatric Infectious Diseases, Department of Pediatrics, Radboud University Medical Center, Radboud Center for Infectious Diseases, Nijmegen, The Netherlands. Electronic address:

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http://dx.doi.org/10.1016/j.vaccine.2017.08.023DOI Listing
September 2017

Characteristics of RSV-Specific Maternal Antibodies in Plasma of Hospitalized, Acute RSV Patients under Three Months of Age.

PLoS One 2017 30;12(1):e0170877. Epub 2017 Jan 30.

Laboratory of Pediatric Infectious Diseases, Department of Pediatrics, Radboud Institute for Molecular Life Sciences, Radboud university medical center, Nijmegen, The Netherlands.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0170877PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5279754PMC
August 2017

Metabolic Oligosaccharide Engineering with Alkyne Sialic Acids Confers Neuraminidase Resistance and Inhibits Influenza Reproduction.

Bioconjug Chem 2017 07 27;28(7):1811-1815. Epub 2017 Jun 27.

Laboratory of Pediatric Infectious Diseases, Radboud Center for Infectious Diseases, Radboudumc , Geert Grooteplein Zuid 32, 6525 GA Nijmegen, The Netherlands.

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http://dx.doi.org/10.1021/acs.bioconjchem.7b00224DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5520103PMC
July 2017

Human newborn B cells mount an interferon-α/β receptor-dependent humoral response to respiratory syncytial virus.

J Allergy Clin Immunol 2017 06 5;139(6):1997-2000.e4. Epub 2016 Dec 5.

Boston Children's Hospital, Precision Vaccines Program, Division of Infectious Diseases, Department of Medicine, Boston, Mass; Harvard Medical School, Boston, Mass.

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http://dx.doi.org/10.1016/j.jaci.2016.10.032DOI Listing
June 2017

Nasopharyngeal carriage of respiratory pathogens in Warao Amerindians: significant relationship with stunting.

Trop Med Int Health 2017 04 9;22(4):407-414. Epub 2017 Feb 9.

Laboratorio de Tuberculosis, Universidad Central de Venezuela, Caracas, Venezuela.

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http://dx.doi.org/10.1111/tmi.12835DOI Listing
April 2017

Advances and perspectives in computational prediction of microbial gene essentiality.

Brief Funct Genomics 2017 03;16(2):70-79

Radboud Institute for Molecular Life Sciences, Laboratory of Paediatric Infectious Diseases, Radboud University Medical Centre, Nijmegen, The Netherlands.

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http://dx.doi.org/10.1093/bfgp/elv063DOI Listing
March 2017

A versatile assay to determine bacterial and host factors contributing to opsonophagocytotic killing in hirudin-anticoagulated whole blood.

Sci Rep 2017 02 8;7:42137. Epub 2017 Feb 8.

Laboratory of Pediatric Infectious Diseases, Radboud Center for Infectious Diseases, Radboud university medical center, Nijmegen, The Netherlands.

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http://dx.doi.org/10.1038/srep42137DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5296863PMC
February 2017

Deciphering the distance to antibiotic resistance for the pneumococcus using genome sequencing data.

Sci Rep 2017 02 16;7:42808. Epub 2017 Feb 16.

Laboratory of Pediatric Infectious Diseases, Radboud Institute for Molecular Life Sciences, Radboud University Medical Centre, Nijmegen 6525 GA, The Netherlands.

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http://dx.doi.org/10.1038/srep42808DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5311915PMC
February 2017

Aptamers for respiratory syncytial virus detection.

Sci Rep 2017 02 21;7:42794. Epub 2017 Feb 21.

Department of Medical Chemistry, Molecular Biology and Pathobiochemistry, Semmelweis University, Budapest, Hungary.

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http://dx.doi.org/10.1038/srep42794DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5318870PMC
February 2017

β2→1-Fructans Modulate the Immune System in a Microbiota-Dependent and -Independent Fashion.

Front Immunol 2017 16;8:154. Epub 2017 Feb 16.

Top Institute Food and Nutrition, Wageningen, Netherlands; Department of Pathology and Medical Biology, University Medical Center Groningen, University of Groningen, Groningen, Netherlands.

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http://dx.doi.org/10.3389/fimmu.2017.00154DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5311052PMC
February 2017

Patterns in Bacterial- and Viral-Induced Immunosuppression and Secondary Infections in the ICU.

Shock 2017 01;47(1):5-12

*Radboud University Medical Center, Radboud Institute for Molecular Life Sciences, Department of Intensive Care Medicine, Nijmegen, The Netherlands†Radboud University Medical Center, Radboud Institute for Molecular Life Sciences, Department of Pediatrics, Laboratory of Pediatric Infectious Diseases, Nijmegen, The Netherlands.

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http://dx.doi.org/10.1097/SHK.0000000000000731DOI Listing
January 2017

Bacterial Lysis through Interference with Peptidoglycan Synthesis Increases Biofilm Formation by Nontypeable .

mSphere 2017 Jan-Feb;2(1). Epub 2017 Jan 18.

Laboratory of Pediatric Infectious Diseases, Radboud Center for Infectious Diseases, Radboud University Medical Center, Nijmegen, The Netherlands.

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http://dx.doi.org/10.1128/mSphere.00329-16DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5244263PMC
January 2017

Alternative pathway regulation by factor H modulates Streptococcus pneumoniae induced proinflammatory cytokine responses by decreasing C5a receptor crosstalk.

Cytokine 2016 12 6;88:281-286. Epub 2016 Oct 6.

Laboratory of Pediatric Infectious Diseases, Department of Pediatrics, Radboud Institute for Molecular Life Sciences, Radboudumc, 6525 GA Nijmegen, The Netherlands; Pediatric Infectious Diseases and Immunology, Department of Pediatrics, Radboudumc, 6525 GA Nijmegen, The Netherlands. Electronic address:

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http://dx.doi.org/10.1016/j.cyto.2016.09.025DOI Listing
December 2016

Role of antibodies and IL17-mediated immunity in protection against pneumococcal otitis media.

Vaccine 2016 11 19;34(48):5968-5974. Epub 2016 Oct 19.

Laboratory of Pediatric Infectious Diseases, Radboud Center for Infectious Diseases, Radboud University Medical Center, Geert Grooteplein 10 (Route 412), P.O. Box 9101, 6500 HB Nijmegen, The Netherlands. Electronic address:

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http://dx.doi.org/10.1016/j.vaccine.2016.09.057DOI Listing
November 2016

Introduction of the 13-valent pneumococcal conjugate vaccine in an isolated pneumococcal vaccine-naïve indigenous population.

Eur Respir J 2016 11 18;48(5):1492-1496. Epub 2016 Aug 18.

Laboratorio de Tuberculosis, Instituto de Biomedicina, Universidad Central de Venezuela, Caracas, Venezuela.

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http://dx.doi.org/10.1183/13993003.00890-2016DOI Listing
November 2016

Highly conserved nucleotide phosphatase essential for membrane lipid homeostasis in Streptococcus pneumoniae.

Mol Microbiol 2016 07 19;101(1):12-26. Epub 2016 Feb 19.

Laboratory of Pediatric Infectious Diseases, Department of Pediatrics, Radboud Institute for Molecular Life Sciences, Radboud university medical center, Nijmegen, The Netherlands.

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http://dx.doi.org/10.1111/mmi.13312DOI Listing
July 2016

Effects of serostatus and gender on the HRV-16-induced local immune response.

Vaccine 2016 07 4;34(35):4087-4091. Epub 2016 Jul 4.

Radboud University Medical Center, 6500 HB, Radboud Institute for Molecular Life Sciences, Department of Pediatrics, 6500 HB, Nijmegen, The Netherlands.

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http://dx.doi.org/10.1016/j.vaccine.2016.06.076DOI Listing
July 2016

Complement Factor H Serum Levels Determine Resistance to Pneumococcal Invasive Disease.

J Infect Dis 2016 06 21;213(11):1820-7. Epub 2016 Jan 21.

Laboratory of Pediatric Infectious Diseases Division of Pediatric Infectious Diseases and Immunology, Department of Pediatrics, Radboud Institute for Molecular Life Sciences, Radboud University Medical Center, Nijmegen, The Netherlands.

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http://dx.doi.org/10.1093/infdis/jiw029DOI Listing
June 2016

Stunting correlates with high salivary and serum antibody levels after 13-valent pneumococcal conjugate vaccination of Venezuelan Amerindian children.

Vaccine 2016 Apr 29;34(20):2312-20. Epub 2016 Mar 29.

Laboratory of Pediatric Infectious Diseases, Department of Pediatrics, Radboud Institute for Molecular Life Sciences, Radboud University Medical Center, Nijmegen, The Netherlands.

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http://dx.doi.org/10.1016/j.vaccine.2016.03.066DOI Listing
April 2016

Reduced Expression of HLA-DR on Monocytes During Severe Respiratory Syncytial Virus Infections.

Pediatr Infect Dis J 2016 Mar;35(3):e89-96

From the Laboratory of Pediatric Infectious Diseases, Department of Pediatrics, Radboud Institute for Molecular Life Sciences, Radboud University Medical Center, Nijmegen, The Netherlands.

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http://dx.doi.org/10.1097/INF.0000000000001007DOI Listing
March 2016

High pneumococcal density correlates with more mucosal inflammation and reduced respiratory syncytial virus disease severity in infants.

BMC Infect Dis 2016 Mar 17;16:129. Epub 2016 Mar 17.

Laboratory of Pediatric Infectious Diseases, Department of Pediatrics, Radboud Institute for Molecular Life Sciences, Radboud University Medical Center, P. O. Box 9101, 6500 HB, Nijmegen, The Netherlands.

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http://dx.doi.org/10.1186/s12879-016-1454-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4794819PMC
March 2016

Actin- and clathrin-dependent mechanisms regulate interferon gamma release after stimulation of human immune cells with respiratory syncytial virus.

Virol J 2016 Mar 22;13:52. Epub 2016 Mar 22.

Laboratory of Pediatric Infectious Diseases, Department of Pediatrics, Radboud Institute for Molecular Life Science, Radboud university medical center, P.O. Box 9101, 6500 HB, Nijmegen, The Netherlands.

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http://dx.doi.org/10.1186/s12985-016-0506-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4802911PMC
March 2016

A novel quantitative PCR assay for the detection of Streptococcus pneumoniae using the competence regulator gene target comX.

J Med Microbiol 2016 Feb 1;65(2):129-136. Epub 2015 Dec 1.

Laboratory of Pediatric Infectious Diseases, Department of Pediatrics, Radboud Institute for Molecular Life Sciences, Radboud University Medical Center, Nijmegen, The Netherlands.

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http://dx.doi.org/10.1099/jmm.0.000204DOI Listing
February 2016

Antibodies enhance CXCL10 production during RSV infection of infant and adult immune cells.

Cytokine 2015 Dec 5;76(2):458-464. Epub 2015 Aug 5.

Laboratory of Pediatric Infectious Diseases, Department of Pediatrics, Radboud Institute for Molecular Life Sciences, Radboud University Medical Center, Nijmegen, The Netherlands. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S10434666153003
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http://dx.doi.org/10.1016/j.cyto.2015.07.024DOI Listing
December 2015

Mucosal IgG Levels Correlate Better with Respiratory Syncytial Virus Load and Inflammation than Plasma IgG Levels.

Clin Vaccine Immunol 2015 Dec 9;23(3):243-5. Epub 2015 Dec 9.

Laboratory of Pediatric Infectious Diseases, Department of Pediatrics, Radboud Institute for Molecular Life Sciences, Radboud University Medical Center, Nijmegen, The Netherlands

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http://dx.doi.org/10.1128/CVI.00590-15DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4783421PMC
December 2015

The post-vaccine microevolution of invasive Streptococcus pneumoniae.

Sci Rep 2015 Oct 23;5:14952. Epub 2015 Oct 23.

Radboud university medical center, Laboratory of Pediatric Infectious Diseases, Nijmegen, The Netherlands.

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http://dx.doi.org/10.1038/srep14952DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4615977PMC
October 2015

Increased protective efficacy of recombinant BCG strains expressing virulence-neutral proteins of the ESX-1 secretion system.

Vaccine 2015 May 11;33(23):2710-8. Epub 2015 Apr 11.

Institut Pasteur, Unit for Integrated Mycobacterial Pathogenomics, Paris, France. Electronic address:

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http://dx.doi.org/10.1016/j.vaccine.2015.03.083DOI Listing
May 2015

Proteomics-identified Bvg-activated autotransporters protect against bordetella pertussis in a mouse model.

PLoS One 2014 18;9(8):e105011. Epub 2014 Aug 18.

Laboratory of Pediatric Infectious Diseases, Department of Pediatrics, Radboud University Medical Centre, Nijmegen, The Netherlands; Laboratory of Medical Immunology, Department of Laboratory Medicine, Radboud University Medical Centre, Nijmegen, The Netherlands.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0105011PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4136822PMC
April 2015

A thioesterase bypasses the requirement for exogenous fatty acids in the plsX deletion of Streptococcus pneumoniae.

Mol Microbiol 2015 Apr 30;96(1):28-41. Epub 2015 Jan 30.

Department of Infectious Diseases, St. Jude Children's Research Hospital, 262 Danny Thomas Place, Memphis, TN, 38105, USA.

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http://dx.doi.org/10.1111/mmi.12916DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4415690PMC
April 2015

Salmonella outer membrane vesicles displaying high densities of pneumococcal antigen at the surface offer protection against colonization.

Vaccine 2015 Apr 14;33(17):2022-9. Epub 2015 Mar 14.

Laboratory of Pediatric Infectious Diseases, Department of Pediatrics, Radboud Institute for Molecular Life Sciences, Radboud University Medical Center, Nijmegen, The Netherlands. Electronic address:

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http://dx.doi.org/10.1016/j.vaccine.2015.03.010DOI Listing
April 2015

Nasopharyngeal gene expression, a novel approach to study the course of respiratory syncytial virus infection.

Eur Respir J 2015 Mar 26;45(3):718-25. Epub 2014 Sep 26.

Laboratory of Pediatric Infectious Diseases, Dept of Pediatrics, Radboud University Medical Center, Nijmegen, The Netherlands Laboratory of Medical Immunology, Dept of Laboratory Medicine, Radboud University Medical Center, Nijmegen, The Netherlands.

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http://dx.doi.org/10.1183/09031936.00085614DOI Listing
March 2015

The adult nasopharyngeal microbiome as a determinant of pneumococcal acquisition.

Microbiome 2014 15;2:44. Epub 2014 Dec 15.

Laboratory of Pediatric Infectious Diseases, Department of Pediatrics, Radboudumc, 6500 HB Nijmegen, The Netherlands ; Crucell - Johnson & Johnson, Leiden, The Netherlands.

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http://dx.doi.org/10.1186/2049-2618-2-44DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4323220PMC
February 2015

Detection and serotyping of pneumococci in community acquired pneumonia patients without culture using blood and urine samples.

BMC Infect Dis 2015 Feb 13;15:56. Epub 2015 Feb 13.

Centre for Infectious Disease Control Netherlands, National Institute for Public Health and the Environment (RIVM), Laboratory for Infectious Diseases and Perinatal Screening, Antonie van Leeuwenhoeklaan 9, P.O.Box 1, 3720 BA, Bilthoven, The Netherlands.

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http://dx.doi.org/10.1186/s12879-015-0788-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4330648PMC
February 2015

Recognition of Streptococcus pneumoniae and muramyl dipeptide by NOD2 results in potent induction of MMP-9, which can be controlled by lipopolysaccharide stimulation.

Infect Immun 2014 Dec 2;82(12):4952-8. Epub 2014 Sep 2.

Laboratory of Pediatric Infectious Diseases, Department of Pediatrics, Radboud University Medical Center, Nijmegen, The Netherlands Laboratory of Medical Immunology, Department of Laboratory Medicine, Radboud University Medical Center, Nijmegen, The Netherlands

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http://dx.doi.org/10.1128/IAI.02150-14DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4249303PMC
December 2014

The role of ZmpC in the clinical manifestation of invasive pneumococcal disease.

Int J Med Microbiol 2014 Nov 19;304(8):984-9. Epub 2014 Jun 19.

Laboratory of Pediatric Infectious Diseases, Department of Pediatrics, Radboudumc, Nijmegen, The Netherlands; Laboratory of Medical Immunology, Department of Laboratory Medicine, Radboudumc, Nijmegen, The Netherlands. Electronic address:

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http://dx.doi.org/10.1016/j.ijmm.2014.06.005DOI Listing
November 2014

From microbial gene essentiality to novel antimicrobial drug targets.

BMC Genomics 2014 Nov 5;15:958. Epub 2014 Nov 5.

Radboud Institute for Molecular Life Sciences, Laboratory of Paediatric Infectious Diseases, Radboud University Medical Centre, Nijmegen 6500 HB, The Netherlands.

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http://dx.doi.org/10.1186/1471-2164-15-958DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4233050PMC
November 2014

Iron-induced virulence of Salmonella enterica serovar typhimurium at the intestinal epithelial interface can be suppressed by carvacrol.

Antimicrob Agents Chemother 2014 30;58(3):1664-70. Epub 2013 Dec 30.

Department of Laboratory Medicine, Nijmegen Institute for Infection, Inflammation, and Immunity (N4i), and Institute for Genetic and Metabolic Disease (IGMD) of the Radboud University Medical Center, Nijmegen, The Netherlands.

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http://dx.doi.org/10.1128/AAC.02060-13DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3957860PMC
October 2014

Binding of human factor H to outer membrane protein P5 of non-typeable Haemophilus influenzae contributes to complement resistance.

Mol Microbiol 2014 Oct 18;94(1):89-106. Epub 2014 Aug 18.

Department of Microbiology, University of Pennsylvania, Philadelphia, PA, USA; Department of Pediatrics, Laboratory of Pediatric Infectious Diseases, Radboud University Medical Center, Nijmegen, The Netherlands.

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http://dx.doi.org/10.1111/mmi.12741DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4497536PMC
October 2014

The vaccine potential of Bordetella pertussis biofilm-derived membrane proteins.

Emerg Microbes Infect 2014 Aug 20;3(8):e58. Epub 2014 Aug 20.

Laboratory of Pediatric Infectious Diseases, Department of Pediatrics, Radboud University Medical Center , Nijmegen 6500 HB, The Netherlands ; Laboratory of Medical Immunology, Department of Laboratory Medicine, Radboud University Medical Center , Nijmegen 6500 HB, The Netherlands ; Facultad de Ciencias Exactas, Centro de Investigación y Desarrollo en Fermentaciones Industriales (CINDEFI), CONICET-CCT-La Plata, Universidad Nacional de La Plata , La Plata B1900 ASH, Argentina.

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http://dx.doi.org/10.1038/emi.2014.58DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4150286PMC
August 2014

Avidity of antibodies against infecting pneumococcal serotypes increases with age and severity of disease.

Clin Vaccine Immunol 2014 Jun 23;21(6):904-7. Epub 2014 Apr 23.

Laboratory of Pediatric Infectious Diseases, Department of Pediatrics, Radboudumc, Nijmegen, The Netherlands.

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http://dx.doi.org/10.1128/CVI.00147-14DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4054233PMC
June 2014

Fc gamma receptors in respiratory syncytial virus infections: implications for innate immunity.

Rev Med Virol 2014 Jan 14;24(1):55-70. Epub 2013 Nov 14.

Department of Pediatrics, Laboratory of Pediatric Infectious Diseases, Radboud University Medical Centre, Nijmegen, The Netherlands; Nijmegen Institute for Infection, Inflammation and Immunity, Radboud University Medical Centre, Nijmegen, The Netherlands.

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http://dx.doi.org/10.1002/rmv.1773DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3973536PMC
January 2014

An in vitro model to study immune responses of human peripheral blood mononuclear cells to human respiratory syncytial virus infection.

J Vis Exp 2013 Dec 10(82):e50766. Epub 2013 Dec 10.

Laboratory of Pediatric Infectious Diseases, Department of Pediatrics, Radboud university medical center.

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http://dx.doi.org/10.3791/50766DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4047926PMC
December 2013

A single amino acid substitution in the MurF UDP-MurNAc-pentapeptide synthetase renders Streptococcus pneumoniae dependent on CO2 and temperature.

Mol Microbiol 2013 Aug 28;89(3):494-506. Epub 2013 Jun 28.

Laboratory of Pediatric Infectious Diseases, Radboud University Medical Center, Nijmegen, the Netherlands.

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http://dx.doi.org/10.1111/mmi.12292DOI Listing
August 2013

Chloroquine modulates the fungal immune response in phagocytic cells from patients with chronic granulomatous disease.

J Infect Dis 2013 Jun 12;207(12):1932-9. Epub 2013 Mar 12.

Department of Pediatrics, Radboud University Nijmegen Medical Centre, The Netherlands.

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http://dx.doi.org/10.1093/infdis/jit103DOI Listing
June 2013

Tuberculosis: from genome to vaccine.

Expert Rev Vaccines 2005 Aug;4(4):541-51

Unité de Génétique Moléculaire Bactérienne, Institut Pasteur, 28 Rue du Docteur Roux 75724 Paris, France.

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http://dx.doi.org/10.1586/14760584.4.4.541DOI Listing
August 2005

Mapping the binding domains on meningococcal Opa proteins for CEACAM1 and CEA receptors.

Mol Microbiol 2003 Nov;50(3):1005-15

Laboratory of Vaccine Research, Netherlands Vaccine Institute, Bilthoven, the Netherlands.

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http://dx.doi.org/10.1046/j.1365-2958.2003.03749.xDOI Listing
November 2003

Conformational analysis of opacity proteins from Neisseria meningitidis.

Eur J Biochem 2002 Nov;269(21):5215-23

Laboratory of Vaccine Research, National Institute of Public Health and the Environment, RIVM Bilthoven, the Netherlands.

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http://dx.doi.org/10.1046/j.1432-1033.2002.03228.xDOI Listing
November 2002